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<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG71</accession>
    <name>A0A1U9NG71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fliN</name>
        <name evidence="4" type="ORF">STSP2_00070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00070"/>
    <dbReference type="EnsemblBacteria" id="AQT66932">
        <property type="protein sequence ID" value="AQT66932"/>
        <property type="gene ID" value="STSP2_00070"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00070"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="3">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11865" checksum="BB479995632B5F2E" modified="2017-06-07" version="1">MAETEQAVEQDAKTTQAQEVELGEAVDSAKGQGEGNLDLLLDITMSITVNLGDAQVPIKQLLQLGPGSVLQMDKLIDEPAELYVQGNKFATGDIVVVDGRFAIRIKEVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG4</accession>
    <name>A0A1U9NGG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">STSP2_00167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00167"/>
    <dbReference type="EnsemblBacteria" id="AQT67029">
        <property type="protein sequence ID" value="AQT67029"/>
        <property type="gene ID" value="STSP2_00167"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00167"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14605" checksum="22B172E1CA6950B4" modified="2017-06-07" version="1">MQAIYQLDVQGDDFLGGLELFLKQESDDDMVFTLARDWARGTWEHLPTCDDLIRKAALKWDLSRLSVVDRSILRLSVYQIRYCSEIPGKVVINEAIEIAKKYSGDQSPRFVNGVLDAVLKKIRDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL8</accession>
    <name>A0A1U9NGL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine monophosphate-protein transferase SoFic</fullName>
            <ecNumber evidence="5">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00223"/>
    <dbReference type="EnsemblBacteria" id="AQT67083">
        <property type="protein sequence ID" value="AQT67083"/>
        <property type="gene ID" value="STSP2_00223"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00223"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="125"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="377" mass="43897" checksum="59BE714518A8AF7E" modified="2017-06-07" version="1">MNMKDFEAGKYLKQYQYKSFSPAYINHTWVWHDPKVNVLLEKAIQALGELNAFSFIVPDIDLFIRMHIIKEAQTSSRIEGTMTEMDEVVMDQNDIAPEKRNDWQEVQNYIKAMNHGVERLREFPLSSRLLCEMHAILMDGARGEHKSPGEFRRSQNWIGGSGLNDAMYIPPSHVEVSNLMNDFENFLHNEDIDVPHLIKAAIAHYQFETIHPFCDGNGRIGRLLITFYFVGNGLLAKPSLYLSDFFEKNRNSYYDALSRVRESNDVLHWVKFFLNAVVTTANKGKDTFQRIIQLKQEMDRLIAQFGRRAENARKLIYRLYSGPVISISEAGEFLDLSPKAAGDLIKQMEDHNILREFTGYKRNRHYIFDRYLEIFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM0</accession>
    <name>A0A1U9NGM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor, CC1-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00093"/>
    <dbReference type="EnsemblBacteria" id="AQT66955">
        <property type="protein sequence ID" value="AQT66955"/>
        <property type="gene ID" value="STSP2_00093"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00093"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25840" checksum="9A5C342E9C1EBB86" modified="2017-06-07" version="1">MNNNFRNFGLVCGGIAGLGCVAGGIAVLTAAVASGDAIFWGMGLFFVGMGFFVGPAMVILTLANTEAVEKEVRTAQKTAGKKASTKKADTKKPAKKDSKSEAKGGEDEPVVIYAGNLPHEAGEAEIRAAFEAFGKVDSVRVITHRSGKSKGYGFVDMPDRAEAEAAIEALNGRDFGGRKLKVSESRSKVSRQRARRKGGNDRPKGKSQPNNKPDNKPSDEKPVEVKREPEVVDWDASVDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH12</accession>
    <name>A0A1U9NH12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67057">
        <property type="protein sequence ID" value="AQT67057"/>
        <property type="gene ID" value="STSP2_00197"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00197"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7764" checksum="57591AC898181DFE" modified="2017-06-07" version="1">MTIMDVLFFVVRVFALVVIIRVICSNNIKALDGERQRAVILLSWAGIFTLSIQFVYDFFRLLNNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH70</accession>
    <name>A0A1U9NH70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67269">
        <property type="protein sequence ID" value="AQT67269"/>
        <property type="gene ID" value="STSP2_00412"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00412"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14314" checksum="91F177715D233C6D" modified="2017-06-07" version="1">MDIRKKTAILALPLTAVVLIGIIIAQPNNGIDYEVTPDITIEPRRSDVVEVVQAYERLMDRYMGMVEQNMSVIGTDVASNVQTLNTIAAQVDTINARLERIEQALDIEQPEEEGAIREIPLQQGRTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB3</accession>
    <name>A0A1U9NHB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00289"/>
    <dbReference type="EnsemblBacteria" id="AQT67148">
        <property type="protein sequence ID" value="AQT67148"/>
        <property type="gene ID" value="STSP2_00289"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00289"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011962321" description="Peptidase M60 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="4">
        <location>
            <begin position="456"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1178" mass="129526" checksum="09E1ED0B67783FCC" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE5</accession>
    <name>A0A1U9NHE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">STSP2_00473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00473"/>
    <dbReference type="EnsemblBacteria" id="AQT67329">
        <property type="protein sequence ID" value="AQT67329"/>
        <property type="gene ID" value="STSP2_00473"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00473"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="150"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17330" checksum="DA7CFE525DA51A43" modified="2017-06-07" version="1">MASYNKVILMGNLTRDPQLSYLPSQTPVCEFSIATNRRFKRQDGSQGEEACFTDCQIFGKRAEVINKYFQKGSPIFVEGRLKLDTWQAQDGSKRSRLRVFVENFEFVGGGSGGGGSRGGNQSQGQPQQYNNNQQFNQGPQDTGEPFNPMDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH0</accession>
    <name>A0A1U9NHH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67194">
        <property type="protein sequence ID" value="AQT67194"/>
        <property type="gene ID" value="STSP2_00337"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00337"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7752" checksum="7B00D59F2D2C1BE5" modified="2017-06-07" version="1">MESGRCGEEKNRVHQDMTWSFHFGPPQNLAAVPPTYFLEGPFSADREIVRLGGAGQTSGKRFNAALIADVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ9</accession>
    <name>A0A1U9NHJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67389">
        <property type="protein sequence ID" value="AQT67389"/>
        <property type="gene ID" value="STSP2_00533"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00533"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010711840" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22136" checksum="95A135340831BE13" modified="2017-06-07" version="1" precursor="true">MRTTAVVLALLMMMTGATSQAGVIEYQHMGKSSDVIMHFAAGVYDGETIPVGEIIVNLDGVPTSVFCVDATGDMLGSAFNTSTVTPGAFAGAAGEKAAYLLDKHFTNGISDVDAAGLQIAIWEVLHESSNTLEVDYNSASAGDFSIENVGSDDVIASADAYLADLVNFAPVSGVEVQKVEEGSDRQDVMLVPEPMSVALLGIGGLWLGRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN0</accession>
    <name>A0A1U9NHN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67110">
        <property type="protein sequence ID" value="AQT67110"/>
        <property type="gene ID" value="STSP2_00251"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00251"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="729" mass="79178" checksum="9B65957807866632" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV9</accession>
    <name>A0A1U9NHV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of autolytic activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgrA</name>
        <name evidence="2" type="ORF">STSP2_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00236"/>
    <dbReference type="EnsemblBacteria" id="AQT67096">
        <property type="protein sequence ID" value="AQT67096"/>
        <property type="gene ID" value="STSP2_00236"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00236"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="159" mass="18051" checksum="E07B9DEBA8EF51DC" modified="2017-06-07" version="1">MSELTQIQEHTAPRRSFLDSYRGRIMIALRRISHFEDQYSKKLSAEYNVTGPQLLCLHILAHSPEMTLSQLSKVASQSGSTTNGIVDRLEMKGLARRERQTTDRRKVIIRLTEKGKQFAQDSSLVLQDKLNHAISELPELKQATMAESLEEIVKLMGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ0</accession>
    <name>A0A1U9NHZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">STSP2_00689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00689"/>
    <dbReference type="EnsemblBacteria" id="AQT67541">
        <property type="protein sequence ID" value="AQT67541"/>
        <property type="gene ID" value="STSP2_00689"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00689"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13153" checksum="7652A755C7EC9F57" modified="2017-06-07" version="1">MHETAVAKSIFDSIVEQAKQHNKKPVRAVVSCGQFNALNDEVLTFAFETIAQDSVCEGMKLEVKHIPLKASCKKCGTTFDFDMYSPLCPECESVEFDFSEDAPLLLEEIELADDENSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI03</accession>
    <name>A0A1U9NI03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67354">
        <property type="protein sequence ID" value="AQT67354"/>
        <property type="gene ID" value="STSP2_00498"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00498"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012097999" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="27421" checksum="F766931AAE7759DB" modified="2017-06-07" version="1" precursor="true">MRSISLILIAVTCTVMLAGCQNIEKENQIFSRYYMTELKTSTSADVLPMIAQDRELTSQSESVIVAWDQKKNHDRIWFNMVAFDEDELTAVRKYAFNTNETPQGIYDLFPTQNIRFDASMVLSEDVLGEPYNTEDARRIAFIEALDDNFDSDIAAVRQDSETLEAGYMLIKQVLNTILHKLDNSPALAQRLSDPAGMEFDHMNFDEGKVRMTTEGDIMKFKVKIGSYVKDFEEHPDVKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI08</accession>
    <name>A0A1U9NI08_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">STSP2_00720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00720"/>
    <dbReference type="EnsemblBacteria" id="AQT67572">
        <property type="protein sequence ID" value="AQT67572"/>
        <property type="gene ID" value="STSP2_00720"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00720"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="598" mass="66012" checksum="01AAAAE4FBC8E7AF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI22</accession>
    <name>A0A1U9NI22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1U9NI22"/>
    <dbReference type="EnsemblBacteria" id="AQT67579">
        <property type="protein sequence ID" value="AQT67579"/>
        <property type="gene ID" value="STSP2_00727"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00727"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013205484" description="Glyco_hyd_65N_2 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="767" mass="86529" checksum="106155188E08ED00" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI29</accession>
    <name>A0A1U9NI29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67166">
        <property type="protein sequence ID" value="AQT67166"/>
        <property type="gene ID" value="STSP2_00309"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00309"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="10053" checksum="5E401E4829239B84" modified="2017-06-07" version="1">MIDNKKRWAKMRKMGKRKFVLVYGVLFWGLLGGLIYSLDWKTFTFDSVGDVVRGVIIFTICGALFGLLLWLQAESRYGEERDEGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI47</accession>
    <name>A0A1U9NI47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67612">
        <property type="protein sequence ID" value="AQT67612"/>
        <property type="gene ID" value="STSP2_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00760"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7500" checksum="240070688FC31E72" modified="2017-06-07" version="1">MPKRFKKMWGRRPEKNAFDLFPRSPNKAGTVRSRSDSAKNGFTAAIGDAIIGVFDLSAASDRLSRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI59</accession>
    <name>A0A1U9NI59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67613">
        <property type="protein sequence ID" value="AQT67613"/>
        <property type="gene ID" value="STSP2_00761"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00761"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798471" evidence="2">
        <location>
            <begin position="24"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36424" checksum="41F44C37E91D46C3" modified="2017-06-07" version="1" precursor="true">MFRKCFSLIFVVSIIAVIFTSGCGQKTANLQLQFQPDETDTFKVTTRTIQSYEFSEPALEKVKQEKTGSTVEMVYDRKITGVAEDGTAQIENTIKELKVFLQDKDGIKYDFDSQRDDDSNDPLAKIVGMSYKISKTPAGKVTVIDAADIRNAVKAGFAGTINKGLFEDKAIIERHEILALPDPEQGEVEVGESWTRIKGSHPRLLDPKSFEKTYTLTSIDKEDGSTVATIDMSAIESAVRAEDHPQSKGFGFMIKMFDTQEEFTGTLKLNLDTGDILLYDETLDAKYIATEESFGAQGPQQQQPEPQQQPDTLTMGFLNSIRLEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI64</accession>
    <name>A0A1U9NI64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67290">
        <property type="protein sequence ID" value="AQT67290"/>
        <property type="gene ID" value="STSP2_00433"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00433"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="30571" checksum="DD1F7014FCCFA709" modified="2017-06-07" version="1">MRHKGSGFTLIELLVVISIIALLLAIMMPALGMVKEKAKSLVCRTNLKTLGLASRLYAEEHNGKMPEQYYYNDAGNFAGYRVWVRQLAPYAAEVDEARYCPSAKVKPKPSDVDLQGAVTGNSRKSWMFKYGDTLDDCEYGCYGLNGWFYSDKEGPNYYKKLGSVKQASSVPLYADAKFVDAWPDDDHYVPEDYDLGGDFWDPYGDTTGNMIRFIMDRHGKRTNLVFADGHAESVALSEMWSLRWHKNFDTQHDVKRGENHDGSPIYQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI98</accession>
    <name>A0A1U9NI98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW_2</name>
        <name evidence="7" type="ORF">STSP2_00801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00801"/>
    <dbReference type="EnsemblBacteria" id="AQT67653">
        <property type="protein sequence ID" value="AQT67653"/>
        <property type="gene ID" value="STSP2_00801"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00801"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44886" checksum="20EF568377E5635D" modified="2017-06-07" version="1">MLKIAPSSRISFYIEVVVLILMATGTAFVFSAGANLSSELDLSQFYKFTTLKQILFFPLAVAVMYTASYIDYRRFSFTRAGAWRSFTPYLLILAIALLTLVLIPGIGVERNYSRRWLELPLGPAAVSFQPSELAKWAVVFFFAAFLDRYRDSMSLYFKRFVPLCVVAGIVCALIVTQDFGTAALIALLAFLMLLAGRAKWWHFLTPLPVVVPMFTYAIMSSPTRINRITRFLDPDQMYHQARQSLIAISTGGIWGKGFGRGIFKYGHLPEDTTDFIFAVICEEMGFVGGVCIILLFALLLVLGIILVCRCKCLFGKLLATGIILSITIQAALNIGVVTVVLPTKGIPLPFISAGGTSMLLTAAMVGVLLNIARQTSAGERLTSDSALADRSWVTTQKSVGNAENGVLCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB2</accession>
    <name>A0A1U9NIB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_00817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00817"/>
    <dbReference type="EnsemblBacteria" id="AQT67669">
        <property type="protein sequence ID" value="AQT67669"/>
        <property type="gene ID" value="STSP2_00817"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00817"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="54"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="349" mass="37906" checksum="71ADEC92F7A18C33" modified="2017-06-07" version="1">MCLEADRNLRTKAYFVDVQVCFVFLKRTSSRKELPVASHFGDRLCVAVEKKRTPLVVGLDPVYDRLPAEIREHPEMNDSEDAGAAIDAVATFCNRVLHLVAGKVPAVKINSAYFEKYLWEGVEAYYALVSEAESLGVEVIGDVKRGDIGHTAGLYSQAHLQNPIMTGLEDIITPDAITVNGFAGADGIVPFADTANAEGKGVFVWVRASNPSAGVIQDFADADGVKMYEKLAEVVGEIAKQSERTGERGYSNVGMVVGGTSPEATTALREKYPEMWILVPGYGSQGATAADCVRFCNKDKMGALVNSSRSIIYAYDKPEYQEKFGGDWEKCIVQAVDDANAELREAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH4</accession>
    <name>A0A1U9NIH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rafA_1</name>
        <name evidence="2" type="ORF">STSP2_00891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67742">
        <property type="protein sequence ID" value="AQT67742"/>
        <property type="gene ID" value="STSP2_00891"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00891"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387305" evidence="1">
        <location>
            <begin position="22"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="847" mass="95237" checksum="25D83C7CF2778BC4" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK1</accession>
    <name>A0A1U9NIK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">STSP2_00908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00908"/>
    <dbReference type="EnsemblBacteria" id="AQT67759">
        <property type="protein sequence ID" value="AQT67759"/>
        <property type="gene ID" value="STSP2_00908"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00908"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21928" checksum="4FD01B3C05D76ABB" modified="2017-06-07" version="1">MTEQNNNENNFDLPRIENAVKEIINAIGEDPDREGLRDTPSRVARMYEELLAGWKSDPSQHLRVFQERYDEIVLLRDIPFYSVCEHHLMPFIGKAHVAYLPDGRVIGVSKLARIVDSFAHRLQVQERCTGQIADFIMEKLQPMGAAVVMEATHGCMTIRGAKKSGAMMVTSALRGIFKSDQRSRSEVLSLIRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN5</accession>
    <name>A0A1U9NIN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cph1_6</name>
        <name evidence="5" type="ORF">STSP2_00930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00930"/>
    <dbReference type="EnsemblBacteria" id="AQT67781">
        <property type="protein sequence ID" value="AQT67781"/>
        <property type="gene ID" value="STSP2_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00930"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012821161" evidence="3">
        <location>
            <begin position="29"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="330"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="572" mass="64822" checksum="E1001B9EA1E2927B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS1</accession>
    <name>A0A1U9NIS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67832">
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        <property type="gene ID" value="STSP2_00983"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00983"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15276" checksum="DC420B8D3530A442" modified="2017-06-07" version="1">MENRTIFLAYLVVWCPYVLAVHFWAHRKRLNLGGVIVSHALPSVVAIVMTYIFLIAGGATVAQFVAGSETGKNLWYLWGFLWPILLFGSATSAFISLVWTIVSCITQSHRKWVFINIAAVMMSVFAFFTVAANFPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW3</accession>
    <name>A0A1U9NIW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Valyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67664">
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        <property type="gene ID" value="STSP2_00812"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00812"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_glycosylase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30048" checksum="952242B4DCF88CD7" modified="2017-06-07" version="1">MKDSNTYAKKIEKLFRSLKKSDLKVPELTYDDPLDAVVDGVLTEHLTLADAEKALKKIQSHFVDYNDLRVSRPEEINDVLKSKNDDKIKAVAKSLPDGLGAIFAKYHAVTLEPLAEEGKRQAKKELEEMVGLSRFAQSYTLLTAIGGHAIPVNQIIADYLKSEKLVNPESDLDDIEGFLERRISAADAFEFYWLLRLQAEESLKAPKKKTTKKRTAKKKKTTKKNPATKKKTAKKTTAKKKTEKKSDTKKKTAKKATTKKKKSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX3</accession>
    <name>A0A1U9NIX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative efflux pump membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01034"/>
    <dbReference type="EnsemblBacteria" id="AQT67882">
        <property type="protein sequence ID" value="AQT67882"/>
        <property type="gene ID" value="STSP2_01034"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01034"/>
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    </dbReference>
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        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="41927" checksum="ED0BF40D76F04913" modified="2017-06-07" version="1">MALRSAKGYVIKRALPAVVWFAALAGTVVLFQYRMQDYKLVGIARDNTRKVSPLENGRIKDVGVRLYQRVNRGQVVARMQDDHIATRLQTIRAEIGKLGAEMDKVRDQMLAEAERLESEKAATHRRFVLDVEAARLKVLELQAQIEPQLIRLGNLQAEVQIEKDLFDAGAVTTDYAVKQAQNEYDVVAESVAENRELLAAAEQAHDKAVARYQQYQEAVADDQNGSLELAIAPIIKEIDVQESLLEELQVQRFALDLRAPADGTVRQILAGEGETVLAGQPIVVVAPEQSTDVVAYVKQNQYVDLRADARVQLIRQAAEPQVADARVYEVSPAYELMPERLWQDPRVPEYGRAVLIEIPQQFEVDPGEVVGVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX8</accession>
    <name>A0A1U9NIX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67466">
        <property type="protein sequence ID" value="AQT67466"/>
        <property type="gene ID" value="STSP2_00613"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00613"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="310" mass="35840" checksum="ACF042A92DC99F0A" modified="2017-06-07" version="1">MIPGVAVKRKVILILAWIFIISGIAYKANSCWQYNQMQHNGHLEIQTRIRFSRFVTYAQTWWPLNRPPRGIPDICLHILQAQSPSDQDDYDLHYEFGSSIERGVLLDDWGRPACLEILSPENYQLISSGPNGKYEKGEGDDILYEFNPHPWGDYGHLRDAYYLRSIDQINVYNINQTDLKNKSLAKATIVALKKNPPVEIDIQLFRDCMSRAYWNTDFYDWKDGYASVVHFPDGKEKIFFLSRTGNYIRIPHAGDYVIAPEKLKKWQTYLKEKVWPKLDSLPKIDPNPKPPSSSHGNNSISYRFPNSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ11</accession>
    <name>A0A1U9NJ11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67919">
        <property type="protein sequence ID" value="AQT67919"/>
        <property type="gene ID" value="STSP2_01071"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01071"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="12028" checksum="C79122C861173DB5" modified="2017-06-07" version="1">MKQVMKTSLSPRRQELVTLMQQINFGRIEDLPVRCGEPVMDSSVRVIRKIKFGSEHRPGPKTGRDFELKKQVTELISQIDRIGTGTIHSLEVKHGLPFVMDVESAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ15</accession>
    <name>A0A1U9NJ15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_4</name>
        <name evidence="2" type="ORF">STSP2_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67728">
        <property type="protein sequence ID" value="AQT67728"/>
        <property type="gene ID" value="STSP2_00877"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00877"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="357" mass="40220" checksum="7BA8CCB1C6ECFEBB" modified="2017-06-07" version="1">MTDNNSGRFDRRTFLKAGTGGLGLAAAGLTANTAYGAQHRGNKKIVQNNNSFERNSEGIPLRPLGKTGEKVPIICLGGHHLGRVEDDQQAINFVRYAVDNGVTFIDNAWEYHRGRSEKIVGRALRDGYRDKAFVMTKTHGRDKETTRKQIEESLRRLQVDTIDLCQVHEVIYRDDPRRFFAEDGGIGPLLQAQKEGKIRFIGFTGHKSPALFTEMMQQFDGWDTLQMPVNAFDPHYRSFIENVMPVAVEKQIAVIAMKTMGGGYLLRPGVISPEQALRFAWSQPVASVVSGMENMDLLKKNIENARIFEPMSEQEQKKLLEKTEPVAKDGEYEKFKTANTFDGWYGRTIHGNQPPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ38</accession>
    <name>A0A1U9NJ38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00674"/>
    <dbReference type="EnsemblBacteria" id="AQT67526">
        <property type="protein sequence ID" value="AQT67526"/>
        <property type="gene ID" value="STSP2_00674"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00674"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26320" checksum="7682FD562C1A623E" modified="2017-06-07" version="1">MSEIADRLEKIEQNICAACERAGRTRESVKLVVVTKTVGTEEIREVIQQGYTDLGESRVQHLKDVAEGVDEYLTINRGRSGVPAGVKWHMIGHLQRNKVKKALKYCSSIQSVDTLRLAEEINTNAGKQGLRPDVFIQVNCSGESQKYGVPVGAAGHLAEQIETMGNLRLVGLMTMAPLTKDDGVIRSCFARAREVFEDIRRDGLAGSQFRHLSMGMSQDYQIAVEEGATVLRVGSAIFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ42</accession>
    <name>A0A1U9NJ42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage tail tape measure protein, TP901 family, core region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01105"/>
    <dbReference type="EnsemblBacteria" id="AQT67953">
        <property type="protein sequence ID" value="AQT67953"/>
        <property type="gene ID" value="STSP2_01105"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01105"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="662" mass="70879" checksum="F0DF959C2A54FEE1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ94</accession>
    <name>A0A1U9NJ94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan endo-1,3-beta-glucosidase A1</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcA_2</name>
        <name evidence="5" type="ORF">STSP2_01019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67867">
        <property type="protein sequence ID" value="AQT67867"/>
        <property type="gene ID" value="STSP2_01019"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01019"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="368"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="609" mass="70501" checksum="43D6F7F83F7DA24C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ95</accession>
    <name>A0A1U9NJ95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">ileS</name>
        <name evidence="15" type="ORF">STSP2_01153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01153"/>
    <dbReference type="EnsemblBacteria" id="AQT67999">
        <property type="protein sequence ID" value="AQT67999"/>
        <property type="gene ID" value="STSP2_01153"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01153"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="713"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="631"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="919"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="939"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="949" mass="107768" checksum="4D82C587F8C243D7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB0</accession>
    <name>A0A1U9NJB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_00964"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AQT67814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17658" checksum="39C3C994797FDC89" modified="2017-06-07" version="1">MVQFIARLTGNDFSKLGVSVELSNGTVCEARYTGDSIFRLKWRIDIEFELACENTKVDFKVISKNLFRTIYAAFDGKKEVLRLVSCIFSDYIIVNGKKERMAGVISTRVENLGFFGESHPFLIGSNYKGEFEDDHILHGTIVATYCVLKMSFTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB4</accession>
    <name>A0A1U9NJB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_00974"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="81" mass="8833" checksum="FCFF27217637E961" modified="2017-06-07" version="1">MLGSPEADDILGAYLLYQDAWAVAEFCRCGRCSWAAFCNVILIELDKSGCASGFGPWGVYSHFGSSVFIYRVIEVNGSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE7</accession>
    <name>A0A1U9NJE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67854">
        <property type="protein sequence ID" value="AQT67854"/>
        <property type="gene ID" value="STSP2_01006"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01006"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31305" checksum="EEF619D0DCA41E76" modified="2017-06-07" version="1">MTRKPNKNHPTLFDLSEHPRTSKNTKNPSPRPASRGPENTTGAHARSSQIHQQMTDTATKAHLICTEPEPTPKPEQPTRNEQPSLFATPAQAGAQHKTTIAKRFHSSKPEQATQPARDHPANKTDHPNTAPPEKMSLRGAEGDAAISKPKNLNGSSIPAWQPPNLDALFARLASSKFRSRFRLKNRELAYLQQKGLPTIMEHARDFITTRIAPADPPNDGKQTPFRNHPVFIAQHATATCCRSCLQKHHNIPKHTPITPTQQTHILNTIQQWLKKQIEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ2</accession>
    <name>A0A1U9NJJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ST-NAGAB-D1</strain>
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            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF17390"/>
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        <source>
            <dbReference type="EMBL" id="AQT68103.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    <sequence length="718" mass="81793" checksum="CCFCD4F6614A29CB" modified="2017-06-07" version="1"> </sequence>
</entry>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <source>
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    </evidence>
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    <sequence length="353" mass="38668" checksum="D6F7E179F5467AB1" modified="2017-06-07" version="1">MLNAIKTGTKVPRVEVIARRIEQDIKASGLEPGDKYKTSLQVARSLKIGNEIANRAMQLLAQRNVIERRHRAGTFVATGMADIDAPALNTIHLVVEKQNVDTYGVLRDGAIAGLHSVLPGTDIRFSFIPATGHEEFIDNLLANAFSSGVTNGFILYRSDEQIQQAVAQSGLPAAISGSRWPGIMNIPCCVADHHSAGKQLAENLIRKGHRKIAFFTRDNMFMSDHELLDGIREAMAQAGCSLSDLTFRSLPLKNFVIQGAARGILQQPEPPTGFICREEILAHNVSQVLGTKEGVVMSDFFEAPRKAAKFPYIRSLMKPEEQGAILGEMLTEMAKKPAEIPNDCVKEVELVEV</sequence>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
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        </subcellularLocation>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AQT68182.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT5</accession>
    <name>A0A1U9NJT5_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">STSP2_01324</name>
    </gene>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="HDOD" evidence="4">
        <location>
            <begin position="9"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="517"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="727" mass="79169" checksum="9BF97C7D65EB8A16" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU6</accession>
    <name>A0A1U9NJU6_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase, bzd-type, O subunit</fullName>
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        <name evidence="2" type="ORF">STSP2_01369</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="459" mass="50770" checksum="A5B32F46D4CE0402" modified="2017-06-07" version="1">MDGPRKISLGEWKQRYERLCASGVIDAGEVRRLGYYFEDGDRRLGKLEFDNSVEALRLWNMLLSEEERLARHRDEGKIIVGAMKDLGTVPVLAYAFDEMVAFYPDGAWWTPCVMQMSAGLLKIADSLGMDESFCPVRAMLGAFVNGKHFPRPDVLTCSAGAVCDDFSVIAQRLEGLGFAIHWWEVPYRREVEKREDAMSLPGGVRAAREQVDFVRGQLEGVLGMLEGAAGRKLDEEELAKSIREANRVRGLLRELRRVVFGAEVCPLGAVEMLVAEMLAIHYCSDRNMCVRVLEGLLELVRKRAARGAGVLDASAVKVFWVNPPADLRVMNLLEDCGARLCGTDYLFTHAIDAISEDVEPMEALARAAMADPMVGSSGQRAERIARDAEEFGAGAVIVSRVPGASHCAMEGTIIRDELKRRTSLKVLEIEVPSVIDADHESLRTRIEALVETVGSVKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX6</accession>
    <name>A0A1U9NJX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT68243">
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        <property type="gene ID" value="STSP2_01399"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01399"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01807">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="291"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="647" mass="74851" checksum="7C5DB5292AA4BAEE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY0</accession>
    <name>A0A1U9NJY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yloB</name>
        <name evidence="9" type="ORF">STSP2_01042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01042"/>
    <dbReference type="EnsemblBacteria" id="AQT67890">
        <property type="protein sequence ID" value="AQT67890"/>
        <property type="gene ID" value="STSP2_01042"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01042"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="903" mass="98623" checksum="2B470BEA1C648076" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK09</accession>
    <name>A0A1U9NK09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68261">
        <property type="protein sequence ID" value="AQT68261"/>
        <property type="gene ID" value="STSP2_01417"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01417"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="25897" checksum="CC47F50AC6DBC90F" modified="2017-06-07" version="1">MKNFYSISHNSFDTRGFPWGEEVLTEIPKRECLRCGGIRFTLEADIDLLLERCKGSKWPDVLGLGMSYFTVSGRVLEDWKREGIGEFPVHRVRIAKPYPKKLEDTAPPNYHWIDGRKMVGAKLDYEASGFVNHKFCDTCGRLLYDDSGTYKKRFQEYCPYVFVPGSWEGADLFTTDYSHLAFFCTEKVLDCARKHQHTNFRFTPIEEGIATNSKGVQYMKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK26</accession>
    <name>A0A1U9NK26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67866">
        <property type="protein sequence ID" value="AQT67866"/>
        <property type="gene ID" value="STSP2_01018"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01018"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12749" checksum="89BB21AF7F944729" modified="2017-06-07" version="1">MQEAEFGGEPIKLVLREGGKLRGRVVDKDGEAVPNAEVKISVKVSETTWIWLGETKTDANGEFAFSAVPVDRYCGVFVYKKPKKDEGEYLFGRVDVTAEVLGAGVVEVADIVLEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK86</accession>
    <name>A0A1U9NK86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparinase II/III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01490"/>
    <dbReference type="EnsemblBacteria" id="AQT68331">
        <property type="protein sequence ID" value="AQT68331"/>
        <property type="gene ID" value="STSP2_01490"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01490"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="129"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="559" mass="64552" checksum="30E11D537D5C3F3F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB2</accession>
    <name>A0A1U9NKB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68362">
        <property type="protein sequence ID" value="AQT68362"/>
        <property type="gene ID" value="STSP2_01522"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01522"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6675" checksum="D2B477F58D43D59F" modified="2017-06-07" version="1">MPKVKIDKNLYKRAEEAAQAEGYSSVDELVIHLIELAVAKSEGGDNADAVEEQLRGLGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD7</accession>
    <name>A0A1U9NKD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
            <ecNumber evidence="4">1.1.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">garR</name>
        <name evidence="4" type="ORF">STSP2_01552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.60" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01552"/>
    <dbReference type="EnsemblBacteria" id="AQT68392">
        <property type="protein sequence ID" value="AQT68392"/>
        <property type="gene ID" value="STSP2_01552"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01552"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="165"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="30482" checksum="0D703B4A247EBBF7" modified="2017-06-07" version="1">MKNIAFIGAGIMGVPMAKNLIEAAYSLTMHSRTQSKAQPVIDAGGTWAQTPAQAAKDADVLITCVTDTPDVEKVLLGPAGVIETAREGLICIDMSTISPAATRKMGETLAAKGVTLIDAPISGGEIGAIEAKLSIMAGGPEDAFNKVKPIFQAMGRTITYCGPLGSGQTTKLVNQVMVIHTIMSISEGLAFAEAAGLDLETTLAATSGGAAGSHSLKVLGPKIIADDLKPSFMVDLQLKDLKLVMEYARQIKQTLPGTALAQQLMTALQAQGRGRDGTQALIDVIRQLGPNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG7</accession>
    <name>A0A1U9NKG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic sulfite reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asrA</name>
        <name evidence="5" type="ORF">STSP2_01455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68297">
        <property type="protein sequence ID" value="AQT68297"/>
        <property type="gene ID" value="STSP2_01455"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01455"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="39095" checksum="CD3F066FEA63B271" modified="2017-06-07" version="1">MSIKKLKKDVFNDLVAALIDSDQRVVGVKAKGDRFAFGDLESADELRLDYDVTLLPPKKFMLPQMETLLKYEVGGEYKSAGEAPKMTLIGVHPYDLVAINQMDEIFAQDEYDKYYMNRRNNITIIACDVVTPSKNVFAGSMGTATVDKGYDVLLTDMGDSYLAEAATDKGEELLAKAAQADDASPQDIEARSKVWQENKEKLNKHKLNCEPGDIPKLLDKEEVYDHPVWEEKASMCYSCGSCTSVCPTCYCFDVQDDVEWNLKEGKRWRAWDGCVLENFATVTGEHNFRKQRAQRFRHRIFRKGKYVPSKIGGQIACVGCGRCVTACTTDIANPVDIYNRLLEDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI6</accession>
    <name>A0A1U9NKI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DsrE/DsrF-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01605"/>
    <dbReference type="EnsemblBacteria" id="AQT68441">
        <property type="protein sequence ID" value="AQT68441"/>
        <property type="gene ID" value="STSP2_01605"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01605"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17080" checksum="13F443948FEED845" modified="2017-06-07" version="1">MKGIVLGYLRDTVLVGLCIGAIGFVGSGCAGPGGSESAGRDDASAGPRADSLAVLWTSGDPAVAEKVCFMYTHNAKKAGWFDRVVLIVWGPSAKLLSEDERLQEYVERMLADGVEVKACKACADSYGVSDRLAELGIEVKYMGRPLTRMLKADGWEVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN4</accession>
    <name>A0A1U9NKN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">apu_5</name>
        <name evidence="4" type="ORF">STSP2_01633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68469">
        <property type="protein sequence ID" value="AQT68469"/>
        <property type="gene ID" value="STSP2_01633"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01633"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012979339" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="894"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1094" mass="115231" checksum="935498B702E11562" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW4</accession>
    <name>A0A1U9NKW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68230">
        <property type="protein sequence ID" value="AQT68230"/>
        <property type="gene ID" value="STSP2_01386"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01386"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15911" checksum="483A912E1CBAAA35" modified="2017-06-07" version="1">MVGAVIGIVWDGCKMTGGWLSGLCRSPLKLEIEYFAYEDVRDDVVVRSCENQERYRVDVSMTNRAQFDVYLKSARLLINKDIRPQFAEHLKGVNLKSGEMKEHSLIFTLDGIEPVSVGDYVLYVVPTVGRTAKTKGHFPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL40</accession>
    <name>A0A1U9NL40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68226">
        <property type="protein sequence ID" value="AQT68226"/>
        <property type="gene ID" value="STSP2_01382"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01382"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17292" checksum="A60B8BF4B36505F9" modified="2017-06-07" version="1">MEQKQNTLKKWLPSPKLNLIISGTCFMIALISLIVGEYIDAITLPEKYFEPAMYLFIPAVILPLFIRLKCGIKNPFWRSVYYAHLCTVGMAIVSGLLITPVVDSNNILVGIASSFVAFVTPLLFLDPLFEILFWQSQCFFCSYFFLQFACIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL45</accession>
    <name>A0A1U9NL45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pncC</name>
        <name evidence="3" type="ORF">STSP2_01682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01682"/>
    <dbReference type="EnsemblBacteria" id="AQT68517">
        <property type="protein sequence ID" value="AQT68517"/>
        <property type="gene ID" value="STSP2_01682"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01682"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="44212" checksum="515C6A19B86991AF" modified="2017-06-07" version="1">MAKAYLVSVGNEILAGQTADTNAAWLAGRLLEKGIAVVGTSVVPDDIDAIKEALILGGRKAEVVLVTGGLGPTDDDITRDALAGFLRVELELREELVERIRRFFAKRGIEMAETNKRQGIMPVGTKDIPNDLGTACGILAEKDGKIFACMPGVPVEMRKMFDEQISGELAQLDGGEVVVVRKLRCFGTGESTIADLLGDMMKRNREPLVNCTVRGGVITLHMVARGKTVAEAEKLIEPVRQDIRERLGELVFGEDDQTLGQVVGELLAERGMTITVAESCTGGLVAKMLTDTPGSSRYFLSGWVTYSNNAKISELAVDARLIEQKGAVSAEVAAAMAQGARKRAGTDIGIGITGIAGPGGGTEQKPVGLVYISVDFRGDSYVERRVFSHTRELVRQRAAMVALDIVRRKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB2</accession>
    <name>A0A1U9NLB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68699">
        <property type="protein sequence ID" value="AQT68699"/>
        <property type="gene ID" value="STSP2_01871"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01871"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="34704" checksum="515F7EBFCA39EA96" modified="2017-06-07" version="1">MAESKTKLQAPDFARTLRNLLKEAKISQIQLANDIDVTPSVISRLCSKGIGSERTLLKIFEHLEIDTVKASRLLMDWKIETSSGYRKEVYERTLRPSPTEKEYLAELFGGHAWMAYACASVGIPIREILEVAQNNGINSFEELANAKPFKLMSFIREMNKSYPFENIREIFERKSSEAYEPVLLFDFLKLKDAADYLELHNCSGTVYFGVPHFVATRYDFKHNGRIGFHDHTHGVEFVLSVKGKFKLTYKDTVFPLLLEPMKHVYVYDGREKHQLELVDGKTGILMIGRFCPKKRNLSPEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM5</accession>
    <name>A0A1U9NLM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apu_6</name>
        <name evidence="3" type="ORF">STSP2_01634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68470">
        <property type="protein sequence ID" value="AQT68470"/>
        <property type="gene ID" value="STSP2_01634"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01634"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504945" evidence="1">
        <location>
            <begin position="22"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="786"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="930" mass="100790" checksum="0F7AF08F5C57E877" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP4</accession>
    <name>A0A1U9NLP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase A1</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">chiA1_1</name>
        <name evidence="7" type="ORF">STSP2_01927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68755">
        <property type="protein sequence ID" value="AQT68755"/>
        <property type="gene ID" value="STSP2_01927"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01927"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010715563" evidence="5">
        <location>
            <begin position="30"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="128"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1257" mass="137364" checksum="13614F4EE93C933C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR1</accession>
    <name>A0A1U9NLR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase subunit KorB</fullName>
            <ecNumber evidence="2">1.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">korB</name>
        <name evidence="2" type="ORF">STSP2_01586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01586"/>
    <dbReference type="EnsemblBacteria" id="AQT68426">
        <property type="protein sequence ID" value="AQT68426"/>
        <property type="gene ID" value="STSP2_01586"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01586"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="50"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26770" checksum="7F109ACBC1996ED6" modified="2017-06-07" version="1">MEFKKTKVLKDNPTHYCPGCGHGIVHRLVAECIDELGIRERTIGTAPVGCAVLLYNYFDCDIIECSHGRSPATATGIKRVHPDKIVFTYQGDGDLAAIGTAETIHAANRGENITVIFVNNAIYGMTGGQMAPTTMIGQKSTTSPRGRGENHEGPPIKVCELLSKLDGVEYLERVAVNSAKDVRRAKKAIRKGFTNQLGDKGFSLIEVLSMCPTDWKIKPAEAVNFVEEDMKKVFPLGVYKNRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU8</accession>
    <name>A0A1U9NLU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">epsE_1</name>
        <name evidence="3" type="ORF">STSP2_02088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02088"/>
    <dbReference type="EnsemblBacteria" id="AQT68911">
        <property type="protein sequence ID" value="AQT68911"/>
        <property type="gene ID" value="STSP2_02088"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02088"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="572" mass="63488" checksum="FDFC62DA36B22684" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ6</accession>
    <name>A0A1U9NLZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannosylglycerate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mngB_3</name>
        <name evidence="4" type="ORF">STSP2_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.2.1.170" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01930"/>
    <dbReference type="EnsemblBacteria" id="AQT68758">
        <property type="protein sequence ID" value="AQT68758"/>
        <property type="gene ID" value="STSP2_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01930"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125378" checksum="6746A7E6BEE5498A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ7</accession>
    <name>A0A1U9NLZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68953">
        <property type="protein sequence ID" value="AQT68953"/>
        <property type="gene ID" value="STSP2_02130"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02130"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20891" checksum="19A9AED6C9B61896" modified="2017-06-07" version="1">MIGGSQTNIGSNLWANAQEYSYLTERILSVHKDGSVVLFAGGSVDALPSTMAVNAAIGMACSNVKCLLVDMDVVRNPLTSAFDLTVKRDRKVKPLKTCLDDVFIWPAEYFVGDIAALLTKLIRKARKRYGITVIYAPRLDQSPLRHPIARLADWGIIFSENAGQATRLAAVMKQANCKPIGSLRAAKPGMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM10</accession>
    <name>A0A1U9NM10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosamine repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagC</name>
        <name evidence="3" type="ORF">STSP2_01798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01798"/>
    <dbReference type="EnsemblBacteria" id="AQT68630">
        <property type="protein sequence ID" value="AQT68630"/>
        <property type="gene ID" value="STSP2_01798"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01798"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="402" mass="43269" checksum="6CD4927DCF71CEED" modified="2017-06-07" version="1">MNATPIDSRWAGRRNEKLILKILKEQGAMSQTQLCRKLGLGSSTASYIIARLRDKGLLTEKQGVSNRRGPKPTILSINNRGRFILGVEINPSFLLIGAFDFNGDMIEKKKISLGDDHSPERVVSILAENLQNLLQAQSIEEDLILGIGVSLSGSVTSQGRVQMSSTLGWEDVPLKDMISDKLAPPVTVFGTAVRVLAEIGLDPELASASVLYLNVADGVGSTLWMDDRLISGATGKFGELGHIVVDPDGPQCGCGQQGCLEAMISGPAIADRIKKELPDHPQSTLSDRIPPEMKTPELIVEQWASALADGDEYAASIRDFIAETLARIAAVAINLYDPDTIILAGYVASACPDQIADAIKNRMPTDVYDDKVRDISIRTAKSGDESLIRGSAIAILHEALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM19</accession>
    <name>A0A1U9NM19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent malic enzyme</fullName>
            <ecNumber evidence="6">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">maeB</name>
        <name evidence="6" type="ORF">STSP2_02180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02180"/>
    <dbReference type="EnsemblBacteria" id="AQT69002">
        <property type="protein sequence ID" value="AQT69002"/>
        <property type="gene ID" value="STSP2_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02180"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="440" mass="46956" checksum="5C8A62A1B9217FDD" modified="2017-06-07" version="1">MADKPGILGKVTSVIGDVGVHVGSIDLVEVDDQTQVRDILIYCKSKDEVAKTVQGINALDDVEVVDQVDEIMEIHRRGAVEMVSRIPIQSLTDLRMVYTPGVASVCKEIQNNPESAWDWTGLCDRVAIITDGTAVLGLGDIGVVPSLPVMEGKAAIFAEFANLSAIPILVDSKDPKTVIETSLNIAPSFGAIQLEDIAAPACFEIEEALREKLDVPVFHDDQHGTATVVLAALINAIKATGKKTEDCNVIMLGAGAAGIAISKILLDFGVKDIVVYDSTGPIYKGRTERMTKYKDRLADITNKQGQTCPLAEGFKDKDIFIGVAQPNMVSKEMVASMNPDPICFPLSNPVGEISAEDAIDAGAAVYADGRGVNNALAYPGIFRGALDVHADAITLSMQIAAAKKLAEIADEDCLLPDMLDRNVHRQVADAVAADYLNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM28</accession>
    <name>A0A1U9NM28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uvrC_2</name>
        <name evidence="2" type="ORF">STSP2_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01724"/>
    <dbReference type="EnsemblBacteria" id="AQT68556">
        <property type="protein sequence ID" value="AQT68556"/>
        <property type="gene ID" value="STSP2_01724"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01724"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="383" mass="43359" checksum="C381CD15D1D519A3" modified="2017-06-07" version="1">MLDELFDGCLQLDTSEQTAVFFDQLKELPACKGIICFANGQGQAIKLQIAGDIRRQARAKLVSSDDEEEITKTPDISPVTDKVYYTCCYNDFRAMLYYYLSARTIFPDEYRSLVALPKQTYASVGLDFIWPYFATSTSPIAQDKQKVFGPFPSRRAANDFVQILNEVFCLCRRPDLIREGSHKTCPYLQMHTCPAPCDGRISADDYRESVDKAIRTASGGLDGVVKEFESLMREQSKRLEFEQAADCKKKLGKLEQLKKADYQWVNDTEKLAVLHVDRSARVAVEGSKKKVQTYSAFLVRLDRTVEFSDFLLSDELGELENLEAEVSKQTPVEDSRQANERIGILSYFLFRSKKKGLWLDCSRGIPDVGIIKATIESELAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM84</accession>
    <name>A0A1U9NM84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase YwlE</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ywlE</name>
        <name evidence="4" type="ORF">STSP2_02197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02197"/>
    <dbReference type="EnsemblBacteria" id="AQT69019">
        <property type="protein sequence ID" value="AQT69019"/>
        <property type="gene ID" value="STSP2_02197"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02197"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="374" mass="41294" checksum="4E46FA4E4C4A76C2" modified="2017-06-07" version="1">MQTELMTLSKQNRAEAIRRAAKTVENGGLVAFPTETVYGIACRAKEDSIARLDDVKGRAPKKRYTLHIGEASQLDRYVPHVPYRARKLVEKLWPGPLTIVFDIATDKYQDLKNRIGEESFSLLYRDGTLGVRCPDNAVAVELLKTVVWPTVAPSANYAGQPPAVTPDEVLASLKGKVDLVLTDPGAPCREGKGSTVVKVSKGRLSVLREGTYTEKQLNELSAVKITFVCTGNTCRSPMAEAFCRKYLSEKLACGIDEVSEIGYKIASAGVGAWPDRPASEQVCRICQIRGIDATPHRSHLLTRDDALTSDFIFVMTESHRRHILEMFPEVESKCLLLSAEGDIPDPIGGGDEVYRVCAERIYEALKERIDEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM88</accession>
    <name>A0A1U9NM88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ_3</name>
        <name evidence="1" type="ORF">STSP2_02014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02014"/>
    <dbReference type="EnsemblBacteria" id="AQT68838">
        <property type="protein sequence ID" value="AQT68838"/>
        <property type="gene ID" value="STSP2_02014"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02014"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18240" checksum="70423FC3FFFE9B25" modified="2017-06-07" version="1">MAKILAMKYILIDKIKNFEAGKEITATKSVSLAEEYLGDHFPTFPVLPGVLLLQGMVETASWLVRASEDFAHSMVILEEAKNVNYKSFADPGTTIEYHAKVKKMDEDSSTFMAEGKCGDKLIVKARFSLRHFNLADKDPGKAKIDSQVVENLKKRWQLLCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC8</accession>
    <name>A0A1U9NMC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">STSP2_02134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02134"/>
    <dbReference type="EnsemblBacteria" id="AQT68957">
        <property type="protein sequence ID" value="AQT68957"/>
        <property type="gene ID" value="STSP2_02134"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02134"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="524"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="408"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="679"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="896"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134421" checksum="DD1D4D5C86DC95FA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD7</accession>
    <name>A0A1U9NMD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02259"/>
    <dbReference type="EnsemblBacteria" id="AQT69073">
        <property type="protein sequence ID" value="AQT69073"/>
        <property type="gene ID" value="STSP2_02259"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02259"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="20553" checksum="C76A4AEBD93C408B" modified="2017-06-07" version="1">MNNDSQKTNSEQFVALLVPNQRKVQAFILMLVPNKTDADDIFQETICEMWNKFGDFQPGTDFTAWAVTIAKYKVLAFHKRKKNSKLMFSSRVSDLLASVASTKVERLHEHVDVLRQCLGKLSKKEVFLLKMRYEDQLTFKEMSARTGKQPSGLHRMMATIHSRLALCVRRTLRLEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI7</accession>
    <name>A0A1U9NMI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG_1</name>
        <name evidence="4" type="ORF">STSP2_02349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02349"/>
    <dbReference type="EnsemblBacteria" id="AQT69162">
        <property type="protein sequence ID" value="AQT69162"/>
        <property type="gene ID" value="STSP2_02349"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02349"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25706" checksum="FDB410CA30D4EF50" modified="2017-06-07" version="1">MSDKRLAVVTGAARGIGRAIVMELLNQGHDVVGLDINTEQLAELEKASGEAGYQVKTAAVDITDTAKLTETLTQIDKDGGGIGILVNNAGITRDKLMMQMDEDDYDILMSVNLRAAFMATKAVLRSMIRNKFGRIINISSVAGVMGQAGSANYAASKSGLIGMSKSIAREVGKKGVTANCIAPGFIQTEMTEVLADAVKKAAMQAIPMKKLGKPEDIAKTVAFLASDDAGYITGQVLCVDGGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN6</accession>
    <name>A0A1U9NMN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02036"/>
    <dbReference type="EnsemblBacteria" id="AQT68860">
        <property type="protein sequence ID" value="AQT68860"/>
        <property type="gene ID" value="STSP2_02036"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02036"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012662672" evidence="5">
        <location>
            <begin position="25"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="544"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="685" mass="77719" checksum="CD204C9BEA7DB518" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP6</accession>
    <name>A0A1U9NMP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA1_2</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">STSP2_02411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02411"/>
    <dbReference type="EnsemblBacteria" id="AQT69222">
        <property type="protein sequence ID" value="AQT69222"/>
        <property type="gene ID" value="STSP2_02411"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02411"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="400" mass="43600" checksum="E1698B4741FE8139" modified="2017-06-07" version="1">MLKGNAVIGQSGGPTSVINSSLAGVVTAAKDAGCIENIYGMRFGIEGLMDENLIDLGKEVEPTIEGLKTTPSSALGSCRHKLQEEDLPKVLDVLQRYNIRYFFLIGGNDTMDTIHRVEKYAVEKGYDLRGIGIPKTVDNDLYGTDHTPGFASAARYMALSVKQAGVLARDMQKVDQFVIFQCIGRDAGWLVAATALAKQNEDDAPHILCMPERDFDKEKFLADVEKAYKKYGWVSVVCGEGITYADGTPVSASETKDKFNNVEFGAMGGTSVAVQLHKMISEKFGWRGEFQITESLPMSAADRAAQLDIDEAFMAGENAVRLAEQGQSGVMVSLERVPGDTYDCTTGTAPLSEVAVRAKPMPDEFINDEGNFITDAFIEYAKPLLGEMPDYVRLACHKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ7</accession>
    <name>A0A1U9NMZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02301"/>
    <dbReference type="EnsemblBacteria" id="AQT69114">
        <property type="protein sequence ID" value="AQT69114"/>
        <property type="gene ID" value="STSP2_02301"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02301"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010698177" evidence="1">
        <location>
            <begin position="29"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="840" mass="96941" checksum="45A0DF324537DE4A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ9</accession>
    <name>A0A1U9NMZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68980">
        <property type="protein sequence ID" value="AQT68980"/>
        <property type="gene ID" value="STSP2_02158"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02158"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="2">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9360" checksum="47D670466EEDEF79" modified="2017-06-07" version="1">MSSDKLITIAEYENNLDARLAMMWLESNGVKATVTGETLSVVVPEIGWRRIELQVLESDAEEARKLLEEHEKQRDDEIDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN39</accession>
    <name>A0A1U9NN39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69323">
        <property type="protein sequence ID" value="AQT69323"/>
        <property type="gene ID" value="STSP2_02512"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02512"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30627" checksum="E7D391367013AFF8" modified="2017-06-07" version="1">MRFLLIILSFALAGGCVAEQYQMERLGLSDNGLEIHSDDTGVYLQADDRSLLLENAVDGVVLPYTYTFDDTANELVVLISKLSEPPNVIIIDTKAFSIIKSFSIWPTCCTENHSWPAPWQAEIAYDSKLGQLAIVADIHESTCINNSGFEADDIRLHGVRVLMLYDVSTARQIDMQPLYTAEDKYWLASSYGVMFASGNTAIIVSGSYGEQNILSECLGPHFLTTKGVVLAYRVNALGLDEEAVYYDLPASVLQKELDWLYSPAGISYLNENGVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB2</accession>
    <name>A0A1U9NNB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage 0 sporulation protein KA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oppA_3</name>
        <name evidence="3" type="ORF">STSP2_02568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02568"/>
    <dbReference type="EnsemblBacteria" id="AQT69379">
        <property type="protein sequence ID" value="AQT69379"/>
        <property type="gene ID" value="STSP2_02568"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02568"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301697" evidence="1">
        <location>
            <begin position="32"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="89"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="595" mass="67698" checksum="4A4D8751D8112FAB" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC6</accession>
    <name>A0A1U9NNC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnA</name>
        <name evidence="3" type="ORF">STSP2_02433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02433"/>
    <dbReference type="EnsemblBacteria" id="AQT69244">
        <property type="protein sequence ID" value="AQT69244"/>
        <property type="gene ID" value="STSP2_02433"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02433"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="702" mass="77915" checksum="ABCE176879525906" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND1</accession>
    <name>A0A1U9NND1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_2</name>
        <name evidence="5" type="ORF">STSP2_02611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02611"/>
    <dbReference type="EnsemblBacteria" id="AQT69421">
        <property type="protein sequence ID" value="AQT69421"/>
        <property type="gene ID" value="STSP2_02611"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02611"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26910" checksum="35A4B479E83808F9" modified="2017-06-07" version="1">MEDNSLMTHIDANAQKESILLMEKLCKNYQLGPTKLRVLREIDMTINTGEYVTIMGPSGSGKSTLLNMIGCLDRPTSGSYKLGGVDVSELEDDELSKIRGARIGFIFQSFNLISQLNVIENIEIPMFYQNYSEEESNERAKELAEMVGLGDRMRHRPSELSGGQQQRVAIARALANDPLIILADEPTGNLDSQSGSDILDILDRLHEEGKTLVVVTHDENIATHAQRAIRLFDGQIAEDVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI2</accession>
    <name>A0A1U9NNI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase</fullName>
            <ecNumber evidence="3">2.7.8.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gumD</name>
        <name evidence="3" type="ORF">STSP2_02653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.31" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02653"/>
    <dbReference type="EnsemblBacteria" id="AQT69463">
        <property type="protein sequence ID" value="AQT69463"/>
        <property type="gene ID" value="STSP2_02653"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02653"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="341"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="554" mass="62659" checksum="99E413CE158C475E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI5</accession>
    <name>A0A1U9NNI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxide operon regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">perR_1</name>
        <name evidence="3" type="ORF">STSP2_02546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69357">
        <property type="protein sequence ID" value="AQT69357"/>
        <property type="gene ID" value="STSP2_02546"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02546"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16795" checksum="88D79DC4918B8CB8" modified="2017-06-07" version="1">MSTSNSDKRAKELLSKAKLRRTKQRVDILSALLDGRGPMSQEQISDAIDGTGPNKATVYRAMESLVGKGVVHRAFERNGTCYFELGDRFGDRQCHPHFTCTECNRTHCLTDFEVPMVKSQKGFQVSHQKIELEGMCPRCADRQEDEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL0</accession>
    <name>A0A1U9NNL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02684"/>
    <dbReference type="EnsemblBacteria" id="AQT69493">
        <property type="protein sequence ID" value="AQT69493"/>
        <property type="gene ID" value="STSP2_02684"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02684"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18400" checksum="22496531AD306B88" modified="2017-06-07" version="1">MSITFNADEIFEMAIEIERNGAKFYRKAADNSSDPETKKMLTSLAEMEDGHEKTFLEMRESLNELEKEENTFDPEGEAEMYLQSMASAHGYEGKKSLDETLTGNESREEILRAALGAEKNSVAFYLGIKDIVPQKAGKDKVQNIIREEMSHIQTLNKALASIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR4</accession>
    <name>A0A1U9NNR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator rcp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rcp1_2</name>
        <name evidence="3" type="ORF">STSP2_02627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02627"/>
    <dbReference type="EnsemblBacteria" id="AQT69437">
        <property type="protein sequence ID" value="AQT69437"/>
        <property type="gene ID" value="STSP2_02627"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02627"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18529" checksum="A7D1DF764D0B2084" modified="2017-06-07" version="1">MVRETTILIAEDDAGHFLLVKKNLWQSCVAQDILHFKDGQEVLNFLFKRGDGPVREDGRSYLLLLDIRMPKVDGREVLRQIKQDEDLRDMPVIMLTTTDAPDEINRCYELGCSFYIIKPVDYRDFMDSVSNLGAFLSLSGVKIPSLAGSGEHEHIASEHKSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW1</accession>
    <name>A0A1U9NNW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69300">
        <property type="protein sequence ID" value="AQT69300"/>
        <property type="gene ID" value="STSP2_02489"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02489"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="18482" checksum="58C2C9CB8B798538" modified="2017-06-07" version="1">MSYPHEHPNAVIASGKAAWLSQSPQKSLLTQHTPPRTVIRRRRTQRTSRLRMYAPPLCHPGLRAGAQRTQRAHMHTQNTLHHYLLSAFVTSIPNSQANFSSPTLYRRNYQKKQPFLNIDFSRYMIKAIIELLIFLLTKQIKGAANEKQNIHNSFDRLSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY7</accession>
    <name>A0A1U9NNY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02634"/>
    <dbReference type="EnsemblBacteria" id="AQT69444">
        <property type="protein sequence ID" value="AQT69444"/>
        <property type="gene ID" value="STSP2_02634"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02634"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="641"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1477" mass="162694" checksum="0EBD6A68252AB1CB" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP00</accession>
    <name>A0A1U9NP00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase EpsE</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsE_2</name>
        <name evidence="2" type="ORF">STSP2_02638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69448">
        <property type="protein sequence ID" value="AQT69448"/>
        <property type="gene ID" value="STSP2_02638"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02638"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="308" mass="35302" checksum="88A9E4DF09C9033F" modified="2017-06-07" version="1">MKPLVTVGMPVYNGSKYLREALDSLLGQSFRDFKLIISDNASTDDTPMICAEYAAKDHRIDYFRHESNKGAAFNFNFVFNKCNSKYFKWAAHDDICKASYLEKCVTVLESADDDMILAHTQAKTIDRGSAVIANIETFSIEQQKRSERFDYLIRHIPPCTSVFGLIRSEALRKTDLLGRYYASDVVLLAQLSLMGKFALIEEPLFLRRKHPESSLHLDPTHRGIARWFDTSNNQALIMPALRLLKGLTETVRKADMSLAEKAACCKVLMKYWIPQKKKYLVRDITLPVRYPFNQIIQKSSLIFRGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP25</accession>
    <name>A0A1U9NP25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="6">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbaB</name>
        <name evidence="6" type="ORF">STSP2_02739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02739"/>
    <dbReference type="EnsemblBacteria" id="AQT69547">
        <property type="protein sequence ID" value="AQT69547"/>
        <property type="gene ID" value="STSP2_02739"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02739"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="5">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18443" checksum="9E0613D3C8261572" modified="2017-06-07" version="1">MRQENVGKLAWSVVGFILMVIVLFAVVRYSGQDVVDQGEHAGHEHGSEAEQAGPQGRGSVAVNGAAENGSMELSGTVQDGVRVVEVTAKQFRFEPGRIVVKKGENVKLKITSVDVTHGFALNEFGIDVKLEPEKPVEVTLTAKEAGTYPFQCSVYCGRGHMQMDGELVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP38</accession>
    <name>A0A1U9NP38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_4</name>
        <name evidence="9" type="ORF">STSP2_02908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02908"/>
    <dbReference type="EnsemblBacteria" id="AQT69712">
        <property type="protein sequence ID" value="AQT69712"/>
        <property type="gene ID" value="STSP2_02908"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02908"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="421" mass="45587" checksum="7F69685CA7361F78" modified="2017-06-07" version="1" precursor="true">MFAGMLSFVRQLLEGVWVAIGQIWSNKTRSALTTIGLVIGVASVCAVIAGLTGLKTKVLSEFESVANARSIYLMGNRPQEGRLKNAPWEEIVLKPDELDGLLDHCPSVENFTMIRQNSWSVRSGERSVDSIPVTGISRAWHEIEGRSVIMGRPFSLVDSEHARRVCLITPDLRDELRLNRDCIGESLLMGDARYLIVGVVEEKVQPSMFGMMDNSSAKGEAFVPFATMYKASGGGWMHAIVTSKSPEVSADAQAEIRFYMRRARDLKPGDPNTFRMEVVEKFISGFKKVAAVMTAIAGGIVAISLLVGGVGIMNIMLVSVSERTREIGLRKAVGAKASAIMFQFLIEAVILCMLGGLIGIGAGQLLTAGMASMPNGLDEAHIPFWAILLSLAFSGLVGVVFGMFPAVKAARLDPIEALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN1</accession>
    <name>A0A1U9NPN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69466">
        <property type="protein sequence ID" value="AQT69466"/>
        <property type="gene ID" value="STSP2_02656"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02656"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188768" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="15921" checksum="EE2A27FBBFA685EA" modified="2017-06-07" version="1" precursor="true">MNLKLMTTIIVLAFAATATASFDYAALDESQASATGWQLEATGVEPTLPASAKKTDKFVVRSGKWGTDDEDVDPEDVLAVKPGNGNANGIVKNVIPKNLVPGNGNWEDVSSGVVQTPTNGDATDGPSATPLPSSMTLGLIGVSMVGLLRKRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY7</accession>
    <name>A0A1U9NPY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">gpsA</name>
        <name evidence="15" type="ORF">STSP2_02769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02769"/>
    <dbReference type="EnsemblBacteria" id="AQT69576">
        <property type="protein sequence ID" value="AQT69576"/>
        <property type="gene ID" value="STSP2_02769"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02769"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="180"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35322" checksum="AFC16667C97FF708" modified="2017-06-07" version="1">MIKNVSIIGDGAMGSVCAMLLVENGINVKLWGHDADYVRLLADKRENVKFLPGYKLPDEIAFEPDDDQAMKGADLILSAVPCQYMRSVWTRLKPHTPPLIPVVSVTKGIEKGTLLRPSQILSEIIGPDRHYAALSGPTIADEIVRKLPATSTAASTDLELARDIQQAFNSARFRVYTNSDLDGVELAGALKNVIAIAAGVIDGIGAGDNAKAALLARGLAEIKRLGLALGANENTFAGLSGLGDLVTTCVSPKGRNRSFGERIGKGQSAEQALSATDSVVEGAATCVSVLELAGKYDVEMPITQAVYDVIYGGKTVQEGIQDLMTRELKSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ2</accession>
    <name>A0A1U9NPZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug transporter MdtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtB</name>
        <name evidence="2" type="ORF">STSP2_03202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70001">
        <property type="protein sequence ID" value="AQT70001"/>
        <property type="gene ID" value="STSP2_03202"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03202"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
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        <location>
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        <location>
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        <location>
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            <end position="936"/>
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    </feature>
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        <location>
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            <end position="967"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117965" checksum="3F18221963D62EAD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH0</accession>
    <name>A0A1U9NQH0_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <location>
            <begin position="95"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="39157" checksum="7996805821FE3D19" modified="2017-06-07" version="1">MTSRERVLSVFEHDLPDRVPCWCGSSVEFWEKAKKELGLDDEGLRLRFKDDFRRVFAEYAGPEFALEHPKAICRTPFGIEREGYGYGQPLSHPLADATLEDVEDYTWPDPAWMDVSKIKQAAQAYNGQFAILGGEWSPFWHDAIDLVGMENLYIKMYSEPEVVDAILKHIVDYYFEVSKRTFDAASDAIDIFFMGNDFGSQTGPLMSPDMFDRFMAPHLARLCDLGHSYGLKTQLHCCGGVYELIPSMIEAGLDGYHAVQTSCRGMDLHKLKSEFGDKIVFNGAIDSHHTLIEKDTQGVIEDTRKVLDTMMPGSAYIAGASHDTILEETPVENVLAMFDAVVEYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL8</accession>
    <name>A0A1U9NQL8_9BACT</name>
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        <recommendedName>
            <fullName evidence="3">Ada_Zn_binding domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">STSP2_03220</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="228"/>
        </location>
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            <end position="183"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24768" checksum="AEAA15DF531676BB" modified="2017-06-07" version="1" precursor="true">MSIKRISLLTLIAASTVCIAGAKLAPGQKNYGNATVKRFIQSDEPFVFTCDIDGFPPVVGKNIPVRIAELAPPAIVAESEKPNLFYNKQLADFITEKLSAAKKIELKGIRRGTTSFQLVADVYIDGQSLAWTLIKKGLARHYVPPVKNTPAATGKKEIANTTGPQKQDDTASPTAQPNAPFIASKSSKIFHKPTCRSAKRITDENRVSFNAREQAVKSGRRPCRSCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM5</accession>
    <name>A0A1U9NQM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_03120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69920">
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        <property type="gene ID" value="STSP2_03120"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012075425" evidence="1">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="36732" checksum="DA2A07871B4C2671" modified="2017-06-07" version="1" precursor="true">MKIRMMTTAVVFAAVVFGTAGSALAAEDEPTVLERVRKVEDPELAELIRIAVENLPADSPKGKVVRLVTEKYAQIKLLNEKINQTEKKLGSKNLSDSVRPELVIALASLKAESVSIIAELRETMGIVPSTPLGPKKTEELHTWIHVDFLDGAIRLCNLKRPFENDVCKNNSADAKFVPSERVKEGIKQLLEGTNAFPARITFAAMPSEYDHALALREGLKSYFSSQKDLLHKIDLGSRIHILEPQTVRIQAANRQKEVYLFLGGRSHREVTLEAFLKASDHNLSDPCILPLVFTVEEYSDQRGSSSGLTSKLKKLVEESGVSDWVTIETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ5</accession>
    <name>A0A1U9NQQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_6</name>
        <name evidence="9" type="ORF">STSP2_03469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03469"/>
    <dbReference type="EnsemblBacteria" id="AQT70263">
        <property type="protein sequence ID" value="AQT70263"/>
        <property type="gene ID" value="STSP2_03469"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03469"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="328"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="422" mass="46386" checksum="700D99C3A17C7BD0" modified="2017-06-07" version="1">MNSKLWRNVYLGIENLLLHKLRTLLTMLGVVFGVGSVVAMLSVGEGASSQAMEQIKKVGSNNIILKSVKSQKEESTSSTTRSFMSMYGLTYDDHLRIAETFDTVAQAVPVKIVRKEARLGDRSLELRVVGTAPEWFEMLDRPKVAGRVLTRQDIQNQANVAVLTEYGSRRLLATTNTIGNHVRIGSDFFKVVGIVKSEGGSAGNIQMPDERVDAYIPINIARKYYGDIIQRRTAGSRTRERVELHQIIAKVKEIEHVEQTAAGIKAMLERFHEDKDYQISVPLALLKQARETKRTFNIVLGSIAAISLLVGGIGIMNIMLASVTERTREIGIRRAIGAKRKQIINQFIIETVVLSSIGGLVGIGLGITIPKVITHFSGMPTIITQSSILISFSISIGIGIVFGLYPAVRAANVDPIIALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ9</accession>
    <name>A0A1U9NQQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation-specific penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">spoVD</name>
        <name evidence="5" type="ORF">STSP2_03321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03321"/>
    <dbReference type="EnsemblBacteria" id="AQT70117">
        <property type="protein sequence ID" value="AQT70117"/>
        <property type="gene ID" value="STSP2_03321"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03321"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="50"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="572" mass="63116" checksum="4DFDBDBFEB3CBFBC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS7</accession>
    <name>A0A1U9NQS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcpC_6</name>
        <name evidence="2" type="ORF">STSP2_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70078">
        <property type="protein sequence ID" value="AQT70078"/>
        <property type="gene ID" value="STSP2_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03280"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="417" mass="46883" checksum="62417DE22FB7CE63" modified="2017-06-07" version="1">MNEKAFLITVGFICPAFLVLLGIVVIDMGSPKSSPDEPEKPTFSDILDRLDSRESTAQVAEESEQDDEALEDLARKNLYFEALALEEAVGRLQNAAEKGLSSAQRELALLYYSNQLWAKSLYWASRLADKGEPGIYELYHRFFSDGKEATEWLIKEAEKGNKNAQCWLGKLYDLGKGVSQDTDEAVELYRKAGEKGSACAQFSLGVMYHRKLKDYRTAAKWYTMAAEQGNTSAQVNLGSLFESGKGVIKNNKKALELYRIAAEQGNEGAQFNLGLMYLDGKGVTQDHKEAVKWFTKAAEQGDAIAQCYLGFFYQKGIGLNENHRAAVKWFKMAAEQDNGEAQYNLGLIYCFGRGVLEDKVEAYKWLRLAGINGEKVAKLKNALRQNMTSKQISQARYKARQWIERKEKEQREAAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY3</accession>
    <name>A0A1U9NQY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gcvPB</name>
        <name evidence="5" type="ORF">STSP2_03358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03358"/>
    <dbReference type="EnsemblBacteria" id="AQT70154">
        <property type="protein sequence ID" value="AQT70154"/>
        <property type="gene ID" value="STSP2_03358"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03358"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="482" mass="52500" checksum="8D9E2E6E388FE74A" modified="2017-06-07" version="1">MKLVFEKSVQGRVGHEVAPSDVPTSIHLKEEFLRDDDPALPELSELDVVRHYTELSRANFGVDTNFYPLGSCTMKYNPKMAERIAAMPGFSDIHPLLPQLRGGGMLTQGALEVIYDMDIALREICGMAAFTMQPMAGAHGELTGIMMMAAYHRAKGNKKKTILVPDSAHGTNPASAAIAGYTVKVVPSDDEGLMCLEVLKDMVDDETAGLMLTCPNTLGLFNPHVKEICDIIHSVDGLAYYDGANLNAIVGKVRPGDMGFDIVHLNLHKTFATPHGGGGPGAGPVGVCERLVEFLPVSIVVKRDDGTYALEYDRPNSIGYIAPFYGNFGIVLRAYAYILMCGKEGLPRIAENAVLNANYIKEKLKPYFEIAVDKVCKHECVFSASKQNEHDVHGMDIAKGLIDEGYHPPTMYFPLIVKEALMVEPTETESKETIDGFIEAMIRIAKKAEAEPDELTKAPLTTAVGRLDETKAAKELNLADVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ9</accession>
    <name>A0A1U9NQZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70174">
        <property type="protein sequence ID" value="AQT70174"/>
        <property type="gene ID" value="STSP2_03379"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03379"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8095" checksum="B04B0B01B17B1EC2" modified="2017-06-07" version="1">MLNTKLFVFKNIFSKGGNEPYASLQSDRREDCAAGRDTGCGCGGHDLEHHDRRDIFVDRRVSCVIDDRHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR47</accession>
    <name>A0A1U9NR47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70257">
        <property type="protein sequence ID" value="AQT70257"/>
        <property type="gene ID" value="STSP2_03463"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03463"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010239">
        <property type="entry name" value="CHP02001"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09694">
        <property type="entry name" value="Gcw_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012414395" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30462" checksum="794A0266D772E5EF" modified="2017-06-07" version="1" precursor="true">MKKVILLATVLALCGVTGLASAADGEIGVDASVSYVTKYIWRGFDRLDDAAAVQPSVNLDLGNGFYANVWMSYAGTSGRTDPAVPTSGRVNFTEYNYTFGYANSMCEGESWQTDYAVNWMYYDFIDMPSDVIDMQEINATFAWPNIIGNGITPSYTIIRMWTSEGSATYNDASGWIHVVGLEYDFTIDGFTPDNPEQTIKLFADATYNDGTGLNTENLLGVADQIDHDWSHLKYGAAAPMKLGNGTLTPAIYYQTSMEDTVNDEDEFWGGITYALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG50</accession>
    <name>A0A1U9NG50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00047"/>
    <dbReference type="EnsemblBacteria" id="AQT66909">
        <property type="protein sequence ID" value="AQT66909"/>
        <property type="gene ID" value="STSP2_00047"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00047"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="580" mass="61605" checksum="5297BFB930C0207D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGB3</accession>
    <name>A0A1U9NGB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66971">
        <property type="protein sequence ID" value="AQT66971"/>
        <property type="gene ID" value="STSP2_00109"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00109"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011984731" evidence="2">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="272" mass="31290" checksum="3B011BA52FA13A13" modified="2017-06-07" version="1" precursor="true">MRRTVTILMTAAVLFWLSGSVMGANDNEGRGRGGQGRGRQVSDNDQENGRGRGGGGRGRRARNDEGDDEERGEQRRERQRKQERDEERKQERERDREGDGGKGRGRGEEAQRGRGRSEEAERGRGKSPEADKFSQRMDAIAKQLDREKTKHLRRQARMEKMLEVAEETGNEKVVERVKKLMEKEQKRYDSKMERIAGRMEKAVTGEADKAEKEKGKEDKEEDSDRDEADDDDEADDEDDMDDDDEDEDEDEDEDEDKDDDRDDEDKEAGSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE9</accession>
    <name>A0A1U9NGE9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">STSP2_00149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00149"/>
    <dbReference type="EnsemblBacteria" id="AQT67011">
        <property type="protein sequence ID" value="AQT67011"/>
        <property type="gene ID" value="STSP2_00149"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00149"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="34277" checksum="872148EDDE92C6B0" modified="2017-06-07" version="1">MILILGVTASGKGKLAFELAKQLDGEIISVDSMKVYRRMDIGTAKPPAERRAQIPHHLVDVVEPSESFSVDRYLELAEQAEKDILSRGKTPIAVGGTAMYIKTMLYGLFEGPGTDEAIRDKLRAEMEEIGKGKMHARLGEVDSEAAERIHPNDKKRIIRALEVYELTGKPISSFQTQFESGSIRPDCTVIGLRREKDIESRRINARVKRMIDEGLVDEVRGLLGEDEPLSKQAAVAIGYAEMIEHLQGEMSLDEAVEKIKINTRRFAKSQRTWFKTFREVQWIDIAENEGIDSVLQRALEIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR1</accession>
    <name>A0A1U9NGR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cph1_3</name>
        <name evidence="4" type="ORF">STSP2_00264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67123">
        <property type="protein sequence ID" value="AQT67123"/>
        <property type="gene ID" value="STSP2_00264"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00264"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32982" checksum="1D2CAA42EDD9698F" modified="2017-06-07" version="1">MSEQCDRKSWEELREKILGLGERSTRKSYYPELRRRLDELRSKNAELESILYVTSHDLKSPLVNLKGFGEELKDNCERYHEILEELQLEGEQAEEAAQLRENVELSLHYIDASVQKIDMLLNGLLRLSRLGKVELVWQQIEPKDIVNDILESMRYQLREAGAQIHVEDLPSCWGDAEQVNHVFSNLIDNALKYCHPERKAEIEIAGENCGAECLYRVSDNGVGISEKNRERVFEIFHRLIPDHASRGEGLGLSIVKRIMQRHGGKVWVESEEGAGSTFYLTFPAYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT9</accession>
    <name>A0A1U9NGT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="2">2.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdhC_1</name>
        <name evidence="2" type="ORF">STSP2_00163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00163"/>
    <dbReference type="EnsemblBacteria" id="AQT67025">
        <property type="protein sequence ID" value="AQT67025"/>
        <property type="gene ID" value="STSP2_00163"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00163"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="11"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="25893" checksum="7AF5708CAC71DFC2" modified="2017-06-07" version="1">MQNKESISDPHTQMPLTRIQKLIGGYMHRSKREKPCCYMECTADLTDLVKLRKRFSRQAGIRITTNDFFIAAIGHAIAEFPLFAGRMDETGDFIETTEQTGVGFAVAAPQGLVVPVVKDVSSKSLAQVSADSDHLLRKARSNKLDLDDFDGANVVLSGLGMFGVTSFIAIAPPEAVGIISIGKIVEKALPVDGEIAPRRTMSITLAADMRIVSESYAARFLRRIVDMLENPTCMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW1</accession>
    <name>A0A1U9NGW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, PHB depolymerase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00184"/>
    <dbReference type="EnsemblBacteria" id="AQT67045">
        <property type="protein sequence ID" value="AQT67045"/>
        <property type="gene ID" value="STSP2_00184"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00184"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012437189" evidence="1">
        <location>
            <begin position="22"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="695" mass="78230" checksum="E5409DEED1D5F9FC" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH43</accession>
    <name>A0A1U9NH43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar basal body P-ring biosynthesis protein FlgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00058"/>
    <dbReference type="EnsemblBacteria" id="AQT66920">
        <property type="protein sequence ID" value="AQT66920"/>
        <property type="gene ID" value="STSP2_00058"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00058"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843866" evidence="1">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ChapFlgA" evidence="2">
        <location>
            <begin position="204"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="326" mass="35744" checksum="362EC528553C3AE1" modified="2017-06-07" version="1" precursor="true">MRSAKHNSAIILVLAMMLFASSGAAKTDARLSVYLPRQVTVEGNALRLANLAVLSGADDLKESAGKIDMGKITAEGQKLVIDRRTIMSRLASNGIDTAQVDLKGAKQISVRRSEQEVTAEQLIEKAGTYLKNIPGNAIVTKFEALRSPDSVIIPGESEWTRLSCRQGRIDTNTQKEVLVDIISDGEKVETVSVHFRPRYKRSRIIAKADVEKGKRLTPDNIKLETYLDNTPEPKNWKAPFGYIARKPLSKGEQVKQNYITAPKPEVVIKRNQTLVIKVQTPGLLITTMGKALDDGAVGQTIKVRNVDSGRILVTKVSEDGTVSPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH72</accession>
    <name>A0A1U9NH72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">luxQ_1</name>
        <name evidence="13" type="ORF">STSP2_00425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67282">
        <property type="protein sequence ID" value="AQT67282"/>
        <property type="gene ID" value="STSP2_00425"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00425"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033417">
        <property type="entry name" value="CHASE8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17152">
        <property type="entry name" value="CHASE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="323"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="605"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="725" mass="80475" checksum="A17D6B9266025E24" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH97</accession>
    <name>A0A1U9NH97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">cheB</name>
        <name evidence="8" type="ORF">STSP2_00014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00014"/>
    <dbReference type="EnsemblBacteria" id="AQT66876">
        <property type="protein sequence ID" value="AQT66876"/>
        <property type="gene ID" value="STSP2_00014"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00014"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36378" checksum="64AB859578BD470A" modified="2017-06-07" version="1">MLTLNANIKVLIVDDSAIVRKILSKELNAADGIEVIGTAPDPYIARDKILQLKPDVLTLDVEMPRMDGITFLRKLMASKPMPVVVLSSLTPQGGKTAMEALDAGAVEVMCKPGAAYSVGDACRQLTSVIKAASRVKVQKKATPQSGTASPTQRLAMTETTNKIFAIGASTGGVKALSAVLPYLPANAPGTLVVQHMPAHFTTSFAQRLNGACAMNVAEAKDGDRVIPGRILIAPGGYHMLLQRSGANYYVTVKDGPRVCHQKPSVEVMMNSVAKFAGANAIGAILTGMGADGAQGLLNMKNAGAHTVVQDEATSVVYGMPKEAARVGAAEKIVPLNEVAKTMIGYAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA1</accession>
    <name>A0A1U9NHA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ORF">STSP2_00454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00454"/>
    <dbReference type="EnsemblBacteria" id="AQT67311">
        <property type="protein sequence ID" value="AQT67311"/>
        <property type="gene ID" value="STSP2_00454"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00454"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="130"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="249"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="39827" checksum="BE8BCDBD213F4516" modified="2017-06-07" version="1">MKVKFNRAALQEALGLVTSVVPSRTPKPILQCVQIKTEVDAVTVCATDLEVGINYQVTQVEIEEQGEIVVPADKLSSIVRESVDEVIAIEESEATVEIKGADSHFTIYGHDADQYPSVPGFEGDAHFTISLGKLQEGIELTVFAAAKESTRYALNGILWEVEGKKLTLVATDGRRLARCAVNLDTVEKDSIPDGRIIVPAKTMNLLDRVGGSADTKVSVRFVDNQIVISCGQVIISSNLVEGNFPKYEDIIPKDYTNSIGLNTDAALSAVRRAALLSNEDSKGIKLALSDNKMTFSSRAPETGDAQVEMTIDYSGGEMEIGFNPAFLIDVLKVIKADDFKLELGDSERPGVIRSGDQFLYIVMPVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC9</accession>
    <name>A0A1U9NHC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioK</name>
        <name evidence="4" type="synonym">bioA</name>
        <name evidence="6" type="ORF">STSP2_00297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00297"/>
    <dbReference type="EnsemblBacteria" id="AQT67154">
        <property type="protein sequence ID" value="AQT67154"/>
        <property type="gene ID" value="STSP2_00297"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00297"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50862" checksum="34B9AE52BF23F186" modified="2017-06-07" version="1">MRGIMNESTKKLLETDRKHLWYPFTQMKDWLEDEPVIIESGDGFYLVDTEGRRYIDGVSSLWCNVHGHRVKEIDDAVKGQLGKIAHSTMLGLGQEKAIELAGRLAEISPEGLERVFYSDSGATSVEIAIKMAYQYWRNQGDTKRTKFIALGDAYHGDTIGSVSVGGIGLFHGIFRSLLFETYYVDSPFVYRYEGTEDECRAHGLEQMEALLKNNEGQIAGIVVEPLVQGAAGILVHPEGFLKGVEELARKYGVLLIVDEVATGFGKTGRMFACEKEDVRPDFMCMAKGISGGYLPLAATVTTEKVFEAFLGEPDEHKTFYHGHTYTGNALGCAAAIASLDLFEKNDVLASLDAKIAKMEEWAVKIRELPFVGDARHVGLFGGIELVRDKESKEEFDYEQMVARKLILSMRDKGLMVRNLGNVVVLMPPVGMSVELLDEMMSIIYDSIRDELPGIVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE3</accession>
    <name>A0A1U9NHE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ORF">STSP2_00168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00168"/>
    <dbReference type="EnsemblBacteria" id="AQT67030">
        <property type="protein sequence ID" value="AQT67030"/>
        <property type="gene ID" value="STSP2_00168"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00168"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16239" checksum="53CD5D3EC7EA450A" modified="2017-06-07" version="1">MYKEIKGQLTAGDAKYAIVVSRFNEFITSKLLGGAIDCLQRHGASDDQITVVWVPGAIEITVAAKKVAESGNFDAVICLGAVIRGQTSHYDYVCQQISRGVGQINYDAGVPAIFGVLTVETIEQAVERAGTKQGNAGASAAMSAMEMVNVLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF2</accession>
    <name>A0A1U9NHF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67040">
        <property type="protein sequence ID" value="AQT67040"/>
        <property type="gene ID" value="STSP2_00179"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00179"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="24021" checksum="4A6EF1AEC9B67FE3" modified="2017-06-07" version="1" precursor="true">MKYRLLTVALCMVIFSGCVRSLHPFGTEEDIIYDPNLIGCWQEEGEEETWCFEKGKIEKSYILYMRGDGETIGPFGVHLLKIKGEMFIDMLPCGPEFDMDNPYEFQTLPVHVFAHVKQIEPALQMRFPDPDWFKRLIEDNPKALKHEIVNGEPLVTASTKQMQEFWLKHLETKDAFSKTSNKRKLEKTKPDNIEAKSESNKKGMKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG3</accession>
    <name>A0A1U9NHG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00189"/>
    <dbReference type="EnsemblBacteria" id="AQT67050">
        <property type="protein sequence ID" value="AQT67050"/>
        <property type="gene ID" value="STSP2_00189"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00189"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="32254" checksum="38A0750E597FE3DB" modified="2017-06-07" version="1" precursor="true">MTIINKRNVLTLFALIMLIGLNSCKTTDAKDRRKELKLINWNTLYSFNHKRSTGLGANWIKQQAPDVLGLQELNGNTEKSLNEMAKSWGHEYSVILKEKGFPVGLTSREPIEVIERKVEGFHHGLLHCRTFGIHFFVVHFWPGKDHEARYILNKAKALLEREENVIVMGDFNSHSRKDSDFHATKEFEPLYDVVDMFEKAGFVDVVNKHDKKALVSFGSPILIPKWASTMKEVKARQARIDFIFADKALAEASSMSTILRSDKLDNISDHYPVIAKFSLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI2</accession>
    <name>A0A1U9NHI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67369">
        <property type="protein sequence ID" value="AQT67369"/>
        <property type="gene ID" value="STSP2_00513"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00513"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15809" checksum="6A13B1391CA3981C" modified="2017-06-07" version="1">MAGPELDGRDELVYYFFPPGAAVAGLVSVMAFAWLGWYGVNEVLFFAWPAGLVWWVIHVLRRNWRMAGQTYFLLWAWVLLSYVGAIVMTIVLHYLGWDEERRSLVSQRFGVGMLAVLALMGVVQFYIRRRWWGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM2</accession>
    <name>A0A1U9NHM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase sigma-54 factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoN1</name>
        <name evidence="11" type="ORF">STSP2_00566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00566"/>
    <dbReference type="EnsemblBacteria" id="AQT67421">
        <property type="protein sequence ID" value="AQT67421"/>
        <property type="gene ID" value="STSP2_00566"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00566"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="123"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="327"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="487" mass="55382" checksum="766545618C950FAE" modified="2017-06-07" version="1">MKMSMTGQMRLEQRMKLAPRMIQSMEVLQLPLLALQEKIEAELNSNPVLEIAEERIEAGDEQEESACENLDEKELVVDEKGDNTDDFERLDSINDDFGDYFDQSMSVSARPKTPEKDKKLEAMQNTASSGLSLRDSLLQQWALIDAEDEVKQAGEHIIDYIDEKGYLTTPVEELDKEKHPFNIDHLREALQLVQKLEPAGVGARDLRECMLIQIDQFPEDMSLERKLVEDHWSELLENRLPQIAKKMNVPVELINHAIKRLSKLDTSPGLRVGRDENHPITADVIVEPSPDGGYSVSLAEANMPNLRVNRFYSQMARNRKVDDKTRQFLQKNIHSAQWLMDAIVQRKQTLLQVAQAIVNHQQEYFEKGKLFLKPLPMATIADEVGVHVATVSRAVAGKYMQCPQGLVPLRGFFSGGTKNASGKMQSWDAVKAELQRIVEAEDKSKPLNDDQIRQALADKGIENIARRTVAKYRKLLNIPSARFRKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP7</accession>
    <name>A0A1U9NHP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67274">
        <property type="protein sequence ID" value="AQT67274"/>
        <property type="gene ID" value="STSP2_00417"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00417"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188765" evidence="1">
        <location>
            <begin position="31"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="374" mass="38440" checksum="210F8042801B5A57" modified="2017-06-07" version="1" precursor="true">MKAVNGGVKWQLVCFGVLAAICLAGGNAQAYVDATFDQPGTYTLSGDYENVYVGADGNTYTTTVVMEAGVHVNNMVSVASTGALEVYGGSCGLGVSVAAGGSMVVYGENYAVDGTPVAEGITEVSLGFNTLSWTDAAGTSHSLFIGSDEMVQLPGLAVEENQAPAADAGGPYVVDATSWDGAEVTLNGSASSDPDGDDIVSYEWDIDGDGAADSTQASFVGLFPIGASDITLVVVDSKGLASEPVTTTVTVSTWEVGVDIKPESTDNTINMGSNGVVPVAFLSSSDFDATTIDPLTVTLRGEDFNTGLVKVRGKKQNPMATETDVNGDGLIDLYVKLETEKLAEYELDAVCDFGALTYDGLVVSGSDSITVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR1</accession>
    <name>A0A1U9NHR1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="9" type="ORF">STSP2_00606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00606"/>
    <dbReference type="EnsemblBacteria" id="AQT67459">
        <property type="protein sequence ID" value="AQT67459"/>
        <property type="gene ID" value="STSP2_00606"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00606"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18298" checksum="9A3B6098D49E4AFF" modified="2017-06-07" version="1">MAENTNGSPLIDPAIVAENLGLDKKEATEEKKQKKTGPDQGGFYWGTGRRKSSVARVRVKPGSGKLEINGKELIEYFRLKKDQELVLAPLQAAKGEKSFDVFVNVKGGGTTGQSGAVRLGIARALATYDDGLLPVLRDGGHLTRDSRMVERKKPGQVGARRSFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT8</accession>
    <name>A0A1U9NHT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA_3</name>
        <name evidence="4" type="ORF">STSP2_00637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67489">
        <property type="protein sequence ID" value="AQT67489"/>
        <property type="gene ID" value="STSP2_00637"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00637"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7198" checksum="A5062C1B51D120AE" modified="2017-06-07" version="1">MSTGKVKWFSDSKGYGFITPDDGGNDLFVHHSEIQADGYASLKDDQTVEFEVGEGKKGPCATAVKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV5</accession>
    <name>A0A1U9NHV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor YtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytrA_1</name>
        <name evidence="2" type="ORF">STSP2_00657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_00657"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00657"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14857" checksum="7E9CCD0750BC6351" modified="2017-06-07" version="1">MLLEIDHHSGVPIFRQIVGQVRRQIMVGGLAEGEQLAAVRDLAARLKVNPMTVSKAYSLLEVEGLVERRRGVGVFVARVRKDRLGKMKGELLDGVMDKAAVTAIQLGVSKEDAWDIFEKHYREYDGKSRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI09</accession>
    <name>A0A1U9NI09_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1936003.STSP2_00383"/>
    <dbReference type="EnsemblBacteria" id="AQT67240">
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        <property type="gene ID" value="STSP2_00383"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00383"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="863" mass="100043" checksum="5D9128C56D3E913A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI14</accession>
    <name>A0A1U9NI14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein assembly factor BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bamB</name>
        <name evidence="3" type="ORF">STSP2_00717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00717"/>
    <dbReference type="EnsemblBacteria" id="AQT67569">
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        <property type="gene ID" value="STSP2_00717"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00717"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
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        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341551" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1105" mass="119351" checksum="B7DFC8ED4D3647B2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI89</accession>
    <name>A0A1U9NI89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00645"/>
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        <property type="gene ID" value="STSP2_00645"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00645"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16400" checksum="8F3274AD0EAEA545" modified="2017-06-07" version="1">MNTRGIIGQLARIREAANLLIERELKARCIEGIVPAHGPVLAFLFQQNKPVPIKAIVESIGRVKSTVTVMINTLEKYGYIKKSSCETDNRVVNIELTHRGREIQKDFDEISNTLVDKVYGDMKKKHREELVKQLNQIEQNMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA6</accession>
    <name>A0A1U9NIA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytochrome-like protein cph1</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cph1_5</name>
        <name evidence="6" type="ORF">STSP2_00665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67517">
        <property type="protein sequence ID" value="AQT67517"/>
        <property type="gene ID" value="STSP2_00665"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00665"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="234"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="465" mass="53208" checksum="B363D8BC44A39BCC" modified="2017-06-07" version="1">MQKARQNKSYALIIAFVYALFGVVWILFSDRMLADFAQTPEEMTRLQTYKGWFYVVMMSIVVYLLVRAGERRLRRGHFKELEMAERLREQEEKYRSLVETTSDWIWEIDSDCVCTYCSPKVRDILGYEPEELLGKKPFEFMPEQLAGRARKVQMEAIQECKPLTALEYILYDKQGRGVVLEVSGVPITDDVGDVVSFRGVARDVSERKLAEQQREKLVRLLELKNQELQDIVYVASHDLRSPLVNILGFSGELSSSCERLLKALEEEDSGSEEIESVIRDEIRESLGFITVSSKKMSNLLDGMLQVSRIGTTEVEKEAVDMKRVVDDVLSTMRYKLKEDGMEVHVDQLPDCMGDRQLVDRAFSNIIDNAVKYRDRTRKGVIRISGELENGMSIYCIEDNGVGIAREHQANIFKIFHRLEPEGETKGEGLGLTIVRRIADRLDGRVWVESEPGEGSRFYIALPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ8</accession>
    <name>A0A1U9NIJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="8" type="ORF">STSP2_00902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00902"/>
    <dbReference type="EnsemblBacteria" id="AQT67753">
        <property type="protein sequence ID" value="AQT67753"/>
        <property type="gene ID" value="STSP2_00902"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00902"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8599" checksum="775055761540B2E4" modified="2017-06-07" version="1">MKKGIHPKYDNAKVRCGCGNTFETRSTVDDIHAEICSMCHPFYTGKQKYVDTAGRIDRFKKKYGGDYFKKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK4</accession>
    <name>A0A1U9NIK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00564"/>
    <dbReference type="EnsemblBacteria" id="AQT67420">
        <property type="protein sequence ID" value="AQT67420"/>
        <property type="gene ID" value="STSP2_00564"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00564"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14330" checksum="8763EB0C1C73A47B" modified="2017-06-07" version="1">MSGVLGLDRSELRSRSREPLVPDLDNASEGRHENDLFDAPSFEGAFFYGPAELVKSETNMEHKLKINGEEHSYEADAMPANISQLLQQLEIDAATVVAEIDGQIVERKNFAETSLQPGQQIELIRFVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN8</accession>
    <name>A0A1U9NIN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67608">
        <property type="protein sequence ID" value="AQT67608"/>
        <property type="gene ID" value="STSP2_00756"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00756"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012482502" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21153" checksum="2FBBB63E6DB89F01" modified="2017-06-07" version="1" precursor="true">MKHLLLLSLAVLLLPGAALAGTVLNTNLLVNPGFEDSLNGWVSNGGDNRSNDPAPHSGSSYVFFPSTSTGAVSQTVDLDLGTFTEGDYEANYGGWQARWHGQADAGKITLYFLDQTGAALGSDSLGFHSPVPWELQEGTAVLPGGTEQIIYEFYGVRYEGSNLDSYLDDAFLSISVVPEPATLVILAAGAVICTRKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS7</accession>
    <name>A0A1U9NIS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67725">
        <property type="protein sequence ID" value="AQT67725"/>
        <property type="gene ID" value="STSP2_00874"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00874"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9823" checksum="E6CCEF93B0165A99" modified="2017-06-07" version="1">MAFNEHKNDHVCIADESLELQIASKKIVVPFGHLSEVKGTRDEIVIMTTNKKKHRIPDNMAISLVRRDDLFDKLKRLVPERVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX4</accession>
    <name>A0A1U9NIX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase isoenzymes nickel incorporation protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypB</name>
        <name evidence="3" type="ORF">STSP2_00688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00688"/>
    <dbReference type="EnsemblBacteria" id="AQT67540">
        <property type="protein sequence ID" value="AQT67540"/>
        <property type="gene ID" value="STSP2_00688"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00688"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23599" checksum="34DFC3BFFE6F88F0" modified="2017-06-07" version="1">MKINLNKRILDKNEQWAQLNQKFFEENGVTCVNVISSPGSGKTTTLSRTITDLNSELTIGVIEGDIKTDTDAQKIRQTGAAAVQVETQGACHLSAQQVSNALAEIKAGELDLVFIENVGNLVCPTSFELGEKARVIILSVPEGDDKPIKYPNSFATADAVLINKIDLVEHIDFDTERVEKDIKTVNPGAAIFHISARTGEGMQAWYEWLQEVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY1</accession>
    <name>A0A1U9NIY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67550">
        <property type="protein sequence ID" value="AQT67550"/>
        <property type="gene ID" value="STSP2_00698"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00698"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="21261" checksum="4BD3821588DA5A5B" modified="2017-06-07" version="1">MDNPKTKLEISELSFSLYQRSLHPELFNIYSKRQIRTENYDAQIWATGCSHVVSAYHKGMCLSELISMPGQPLPKRGLVERFQFRGQKNHRCRLSKGVSYMTDFQVEKMSPNLYRQSHIDLERFAKNRGIFVKFPEMSSSGLEPFSYIDFEARKTELHIHAFHAYPDQVTIIKTQSLVGFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY3</accession>
    <name>A0A1U9NIY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysD_2</name>
        <name evidence="8" type="ORF">STSP2_01045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01045"/>
    <dbReference type="EnsemblBacteria" id="AQT67893">
        <property type="protein sequence ID" value="AQT67893"/>
        <property type="gene ID" value="STSP2_01045"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01045"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="33894" checksum="58A6A4E6F5F3F1E2" modified="2017-06-07" version="1">MDHLERLEAQSVFILREAYREFKDLAMLWSIGKDSTVLLWLARKAFFGHVPIPLVHIDTSFKIPAMIEYRDELAMRWNLNMVVGQNTEAVKKRQTFPDGGVSRMDCCRKLKSMALKNTLEGSWPRWVLDHETGKYVQEKDSKPYTGVIAGVRSDEEGSRSKERYFSPRDKENDWDVGDQPPELWNQFKTDFAPGTHVRVHPLLDWTELNIWQYIERENIPIIDLYFDQGDGTRYRSLGCGPCTKPVESTASNVHEIVEELTSGKFANIAERSGREQDKEDGNSLESLRRDGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ7</accession>
    <name>A0A1U9NIZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67795">
        <property type="protein sequence ID" value="AQT67795"/>
        <property type="gene ID" value="STSP2_00944"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00944"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16140" checksum="9E80CD289EFD34EC" modified="2017-06-07" version="1">MKMNSPFSIFVIAAVMLTGGGFGWLTGLAYYSDYWAVGMVAGLISGYPLAKFYLGHLTKKSQSDGDKFYIWLSGTCNAVLCGLICTAIVHGVMIAMIIMVSEKTLFQHTEGFWPLFVAVGMMFGTGAGLVVGGICTSIYVAIAKDPIREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ25</accession>
    <name>A0A1U9NJ25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="46281" checksum="743847B12863B39C" modified="2017-06-07" version="1">MSGKACKSIWNPQVVAWVLYDFSNSAYILLVPAVAFAVYYRQVVAGGHAGADLQWSFLVSLSLAIAGFLAPFIGSLADVGGLRHRLFTLCTVICCLLTGLLWFITDGMVVVGGILFIVANVTYAIAISLYDSYLRSIVDNSRSARLSSIGWGVGYLGGILCFILCYPLLKGGLATDNLVQYRTSFTITAGFYLVFSIPAFIMLRGIVPRENSRSQFSPSIVMKAYAEVIKTVRQWRAHKEIFKFLLAFYFISDAIVTVIYFTAIFLQTNFGMPVTEILILTLIVQLIGIPCTIIAGVLGDRIGKKIVVLATLVVWVGVVLLMVFGRHPVVPYLMAGTMGLVLGSTQAVLRSMFSDMLTENHAAEFFGFNALAGKVSSVLGPLTFGLIATATGSQRLGLASLLLFFGTGAVILTTVKPSRSAKHVSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI3</accession>
    <name>A0A1U9NJI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">STSP2_00889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00889"/>
    <dbReference type="EnsemblBacteria" id="AQT67740">
        <property type="protein sequence ID" value="AQT67740"/>
        <property type="gene ID" value="STSP2_00889"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00889"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="426" mass="45712" checksum="15634C0A513D0282" modified="2017-06-07" version="1">MKLTTSKRLFRNAQKYIPGGVNSPVRALNAVGGQPIFIDKAKGPYLYDADGNRFIDYCLSWGPMILGHAYKPVLDAVRKTLGKGTSFGIPTEIETQLAKTIATAVPSIDKVRLVSSGTEAVMTAVRLARGTTDRDIIVKFIGCYHGHVDHMLVSAGSGLATFGSPSSPGVPDDFAKNTLLLPYNDLDAAKELFKKQGKNIAAVIIEPIAGNMGTIPPAEGFLEGLRTLCSKNKSMLIFDEVITGFRFTFSGVQKMLKVQPDLTCMGKIIGGGFPVGAVGGPAAVMDNLSPDGTIYQAGTLSGNPVCVSAGLATLQALKAEKPYKKLGDSGRKLADGIDEILTAKSIPHTINRMGGMFTLFFNDEPVTDYDGAAACDTKMYAKYFQHMTANGIYVPPSQFEANFLSTTHTDRHIEQTLKAVRSFEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK2</accession>
    <name>A0A1U9NJK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Planctomycetes uncharacterized domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68113">
        <property type="protein sequence ID" value="AQT68113"/>
        <property type="gene ID" value="STSP2_01268"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01268"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188769" evidence="2">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19352" checksum="82519D8B249774DD" modified="2017-06-07" version="1" precursor="true">MKFTNLLTITLIAAIMLAAGCGSEEPAAGTDAEGETTQTETDQPEEQTEAEPAATSETEQSTMDRLQGTWVGTVVGYDGEVKMTFAEGSADFQADLGGISYKGSVVINEDATPAQADYTIDECKFEQYIGKTSLGIFQFEDDTLVLAANEPGKTERPTEFQPMNGTQVFEFKRQMTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL2</accession>
    <name>A0A1U9NJL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68123">
        <property type="protein sequence ID" value="AQT68123"/>
        <property type="gene ID" value="STSP2_01278"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01278"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20480" checksum="ED95EBDEE68C75C5" modified="2017-06-07" version="1">MALYLTFYDEWEDIGNIGDIDEIEDITEQPGMEIDDIAKKILKRLLKRLVGSGSSIIYHRLMNLFPTGTEAKKRSVSRVRLDGEFDVEYQVKRCVGVCKRFLGIPIPFTDGGTKWTDWKKDTKELRVVIAEQDIQIGTYPVLIGSGNVAREVNQFLNNVLNDPVSIEDKVKSKLKKVVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ0</accession>
    <name>A0A1U9NJQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01306"/>
    <dbReference type="EnsemblBacteria" id="AQT68151">
        <property type="protein sequence ID" value="AQT68151"/>
        <property type="gene ID" value="STSP2_01306"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01306"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33799" checksum="F2C34427966596FC" modified="2017-06-07" version="1">MGDGIRTSALVRERAGAGVPFRAFWPFLVIAFAIAWGVLALYIFLPEWMGAVFGELSGRHPLFFLAVYAPAIAAVVVVLWHSGPAGLRGFMSRVLLWRCSWVWYAFLVVGIPLVFVGGAAMRGTLFTDPFAFDSVGGMFAGLGLAVIKGPMEEFGWRGVALPLLQRKFAPIWAGVVLGMIWGVWHLPAFLLSGTQQSEWAFAPFFLGCIALSVIVTPLFNASGGSILLTALFHFTVMNPVLPAAEPYDTYILVVAAGVIVWLNREAMFRRGVAVTEVVGSAFGSPRRTKGTKGKFEKEYGVASRRLIYAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU9</accession>
    <name>A0A1U9NJU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01250"/>
    <dbReference type="EnsemblBacteria" id="AQT68095">
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        <property type="gene ID" value="STSP2_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01250"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="556" mass="61810" checksum="93997820AB93820D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW5</accession>
    <name>A0A1U9NJW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01252"/>
    <dbReference type="EnsemblBacteria" id="AQT68097">
        <property type="protein sequence ID" value="AQT68097"/>
        <property type="gene ID" value="STSP2_01252"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01252"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012685377" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="353"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="700" mass="75127" checksum="E52BEC3653E28311" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK02</accession>
    <name>A0A1U9NK02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ruvB_2</name>
        <name evidence="7" type="ORF">STSP2_01407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01407"/>
    <dbReference type="EnsemblBacteria" id="AQT68251">
        <property type="protein sequence ID" value="AQT68251"/>
        <property type="gene ID" value="STSP2_01407"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01407"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="36506" checksum="9E118BC3DDE0F7A2" modified="2017-06-07" version="1">MSHEIGTDVNQTQITSLSHIKGQPHIVELLRTSLDAYFANRANNSSSSFGPVLMVGPSGTGKTLTAKAIHCELGNLQLIESNGEMLNPTELTSMLLMADENSSIFVDEAQALDARTQHVLLTALSERKVILPKRKNNKKTCSVPLANFTIILATTHEFQLQNALRNRMRLCCRFNYYSADDLTYIVKQRADALKWDYENSEVLHEIAKRAKQTPRIALNRNLQMAWSVCSADGRNVITKEDVCKAFDLLDIDEEGLDTLDQAYLCELSKRNSMKLNVLSSKLGLPSRTISSVIEPYLLRQELIEKQGSERQITEKGKQHISQNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK22</accession>
    <name>A0A1U9NK22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68088">
        <property type="protein sequence ID" value="AQT68088"/>
        <property type="gene ID" value="STSP2_01243"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01243"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30819" checksum="A5DA2DB62EB58D53" modified="2017-06-07" version="1">MKNKEGFTLIELLVVIAIIALLMSIMMPALSMVKERARRVTCGSNLKQVGISLFTYAQDNDNKVPENYMEIAPRYTGFYAYAAYWINPNATNESHKITDGPVNVAVLFDAGYLKDPEIFYCPSARGVSDLLSYDHYVGDLSWPFVHDPDAYHANFVRISYNYLSQGRGREVIECGSSKRDVRVHILDNQVSNMTSSTSMLADVISSQSGALHRAGVNKPAGINVLHGDGHVLFCNEKEAINNDDFWGVDNHDELPNQNGYNLRGILGLFKGTAQIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK27</accession>
    <name>A0A1U9NK27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01440"/>
    <dbReference type="EnsemblBacteria" id="AQT68282">
        <property type="protein sequence ID" value="AQT68282"/>
        <property type="gene ID" value="STSP2_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01440"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15890" checksum="7AE92E438A89EA28" modified="2017-06-07" version="1">MTKQLNVFVENRPGRLESVTQSLLESNINVRAFAMQDRGDYGLLKLIVDKPQEAYLALSEKNFACALKDTLAISVPDKPGNLHKLTTVLAENDINVIDAYGFVLEPDHQGICCLEIENLKETNAPQIVSEAGFEVLSAEELSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK98</accession>
    <name>A0A1U9NK98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01500"/>
    <dbReference type="EnsemblBacteria" id="AQT68341">
        <property type="protein sequence ID" value="AQT68341"/>
        <property type="gene ID" value="STSP2_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01500"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="19071" checksum="8626D9AF45303EEB" modified="2017-06-07" version="1">MFILHCTKKAQDRLKVKPADALSEPTTRFGNWYCNEFTASRRKYMIFVNERTLLPIVISVKGLKTSRDILELFKQRLFKAFLLLQLPEERFMPELMEMDEVVFAKTSNRSIIGSMNDIIAQTKFSSDYHGIDVDSPAMFETLSQIPLKANGYKRSTELVAELLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE0</accession>
    <name>A0A1U9NKE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein, rSAM/lipoprotein system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01359"/>
    <dbReference type="EnsemblBacteria" id="AQT68204">
        <property type="protein sequence ID" value="AQT68204"/>
        <property type="gene ID" value="STSP2_01359"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01359"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010690884" evidence="2">
        <location>
            <begin position="24"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="812" mass="88116" checksum="1BA54BD1738B5BD3" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF6</accession>
    <name>A0A1U9NKF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SelB translation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">selB</name>
        <name evidence="4" type="ORF">STSP2_01374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01374"/>
    <dbReference type="EnsemblBacteria" id="AQT68218">
        <property type="protein sequence ID" value="AQT68218"/>
        <property type="gene ID" value="STSP2_01374"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01374"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="637" mass="69932" checksum="191C471176AF904B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ4</accession>
    <name>A0A1U9NKQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein FixJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fixJ_1</name>
        <name evidence="5" type="ORF">STSP2_01473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01473"/>
    <dbReference type="EnsemblBacteria" id="AQT68314">
        <property type="protein sequence ID" value="AQT68314"/>
        <property type="gene ID" value="STSP2_01473"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01473"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23762" checksum="8A58C587245CAE97" modified="2017-06-07" version="1">MNNSKCGSKTVFLVHHEDCVREYLYNEIQKRGFRCVAFDSPDKCIQRLSDFEPPVLVAPLKIPNSDGLHLLEQIKQHSPCVNLIFFTRYATIARAVKAVRQGAFSLVDHNCHHSRLFEEIEMAIEHGDRINMNLGLTPAETKIFELILEGYSNKEIAKMLHRSVRTIEDHRARIMKKAGAENVVELVKKAFSLGLISNSAGHYEVSAECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS9</accession>
    <name>A0A1U9NKS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphorylated carbohydrates phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01709"/>
    <dbReference type="EnsemblBacteria" id="AQT68543">
        <property type="protein sequence ID" value="AQT68543"/>
        <property type="gene ID" value="STSP2_01709"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01709"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25124" checksum="8661EF3AD1EBC6E7" modified="2017-06-07" version="1">MLKAVIFDFDGVMVDSEPLHFKAFQQVLADKGVKLSKEQYYTTYLGYSDYDCVAEVSRDFELELTDSEVEDLIKLKTVAFEDLARQDGCLIEGVREFVSMLCDKGIRMAICSGALRSDIDLLLRSTELTADFETIVTADDVVRSKPDPESYHKVLEGLKAAKTIDSDECVVIEDSHWGLAAARAAGLKCIGVTNTYSAEALDGNADIIVDNLQDLKLDELNKLCSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL21</accession>
    <name>A0A1U9NL21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">srrA</name>
        <name evidence="3" type="ORF">STSP2_01438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68280">
        <property type="protein sequence ID" value="AQT68280"/>
        <property type="gene ID" value="STSP2_01438"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01438"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14219" checksum="B31674C5A2FC8970" modified="2017-06-07" version="1">MAKRVLIIDDDADFRESIANLLEAKNYNVSAAANGQEGIEKAKSDTPNIILLDVMMTTKSEGFDVARELQKIDSLKGTPVIMITGVRKEMNLPFGFEPDEDWLPVKDVLEKPVKPEDLLKAVQKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL27</accession>
    <name>A0A1U9NL27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68507">
        <property type="protein sequence ID" value="AQT68507"/>
        <property type="gene ID" value="STSP2_01672"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01672"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9439" checksum="1DCFA251246F2B63" modified="2017-06-07" version="1">MAKEFNPTKAKILGYAATISGFLAILIGLLLYFARPDHEHIMVVLLVLLGVGFIDILLGVVFFYTARLAEKHFQENYGISKDGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL75</accession>
    <name>A0A1U9NL75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor SigX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68659">
        <property type="protein sequence ID" value="AQT68659"/>
        <property type="gene ID" value="STSP2_01828"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01828"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20578" checksum="05D2BD05A9F1D867" modified="2017-06-07" version="1">MSNGEPWPADLIANQYGGFIYRVICSRVTDRSLVNDVYQDFYLSLVHKPVPPDVRKMESYLYRRIANHIADTYRKIKRHRDLLQNYSEFLKIQGDEDTSSNDYCKEADRVLSKAKNCLSQREYDAIIMKYKQSCAVKDIARSMGVQRESASRYLYKGLRKIRKAVENSSLGQECQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR4</accession>
    <name>A0A1U9NLR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease E</fullName>
            <ecNumber evidence="7">3.1.26.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rne</name>
        <name evidence="7" type="ORF">STSP2_02057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.26.12" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02057"/>
    <dbReference type="EnsemblBacteria" id="AQT68881">
        <property type="protein sequence ID" value="AQT68881"/>
        <property type="gene ID" value="STSP2_02057"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02057"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="57649" checksum="BCB0969D3E251D78" modified="2017-06-07" version="1">MSKEMLINSVQGEECRVAVVDNKKLDELYIERASLVSHVGNMYKGKIVNIEPSIQAAFIDFGLAKNGFLHISDVHPKYLSGKADKSEKIGRRQSLSKRPPIQRCLKKGQELIVQVTKEGIGTKGPTLTTYLSLPGKHIVMMPGMSKVGVSQKIEDEDERKRLKKIIDSLELPKDFGFIIRTAAIGATKRSLRNDVNYLTRLWKAIRKKMETSKAPAEIYKESDLVIRTIRDVFTSSISKIVCDSEIVSKKARDFLSIIQPRLKRRVIYYDGKTPLFHKYGIEQEITNIQSSRVELNCGGSLVIEQTEALVAIDVNSGRYRKHENAEATAHKTNMEAAKEIVRQLKLRDLGGLIVCDFIDMRDRKNKRQVEQIFRDELKSDRARSKALRMSAFGLIEVTRQRMRPSLQSTTYLKCPRCGGKGIIKNLESQSLELMRTLNLAVARGDIKRIEMLVEPDVASFMLNENRAAITQIETQSDKQILIKGDPNVLGDDFKIDCFNERGSKVQFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS3</accession>
    <name>A0A1U9NLS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein YycF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yycF_1</name>
        <name evidence="3" type="ORF">STSP2_01858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68688">
        <property type="protein sequence ID" value="AQT68688"/>
        <property type="gene ID" value="STSP2_01858"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01858"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14639" checksum="6CB8264D65177389" modified="2017-06-07" version="1">MRVRILIVDDERDYLALMQLNLDIEGYEVGTACTESEALASLESRRPDLILMDVDMGEESGLDITSRLKKNPETADIPLIMVTGEDSEEDRVRGFEAGADDYVTKPFELTFLLERVRAVLGGERMQAPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM43</accession>
    <name>A0A1U9NM43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68804">
        <property type="protein sequence ID" value="AQT68804"/>
        <property type="gene ID" value="STSP2_01979"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01979"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19885" checksum="E1CD6B0EBEFF2CB9" modified="2017-06-07" version="1">MKITGAHKRFLLISLSVVLFPCCLYAGVDLDGLNTGITFRVSELEAGRWQYDYTVENISLPEGIGEFTIYFDPDHCSALRVETAGLIADTWNEFVWDPVRSIGVEGGYDAMAGAFPIGPSMIAYGFSVSFDWSGQGRPGAQYYEIIDPETFEEVDSGWTVPEPSTLALLCVGVFFAGRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM56</accession>
    <name>A0A1U9NM56_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68808">
        <property type="protein sequence ID" value="AQT68808"/>
        <property type="gene ID" value="STSP2_01984"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01984"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="46975" checksum="324E4045495F3AB0" modified="2017-06-07" version="1">MQKNESDRSVADLNKAIKIDESQIQNHLGEMVRSTVEQTLNNMLDAEADQLCNAKRYERTSERVNSRAGHYKRNLHTRSGEVKVKMPKLRRAKFETAIIERYRRREASVEEALMEMYLAGVSVRRVEDITEALWGMRVSAGTVSDLNKKMYERIDEWRNRRIEGEYPYVYLDGICLKRSWGGEVRNVSVLVAIGVGKDGYRDILGVVEGGKEDRDGWSGFLRSLKQRGLKGVQLVVSDKCLGLVESLGEFFPDARWQRCTVHFYRNVFSVVPRGKMQEVSAMLKAIHAQEDLAEAKKKAHAVADKLDGMKLRRAAQRVREGAQETLSYYHFPRKHWRQIRTNNPLERIMREIRRRSRVVGCFPDGNSALMLAAARLRHIAGTKWGTRRYMNMDRLREMQNEAIAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM67</accession>
    <name>A0A1U9NM67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigM_2</name>
        <name evidence="4" type="ORF">STSP2_02102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68925">
        <property type="protein sequence ID" value="AQT68925"/>
        <property type="gene ID" value="STSP2_02102"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02102"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="613" mass="69009" checksum="8A9845AEDFCEC237" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM99</accession>
    <name>A0A1U9NM99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor IF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infC</name>
        <name evidence="6" type="ORF">STSP2_02236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02236"/>
    <dbReference type="EnsemblBacteria" id="AQT69051">
        <property type="protein sequence ID" value="AQT69051"/>
        <property type="gene ID" value="STSP2_02236"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02236"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="4">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15885" checksum="6F7C9198A35090B1" modified="2017-06-07" version="1">MSRARDAGLDLVEVAPNSKPPVCKVMDFGKWLYEQKKKNKQSQKKQHVVHLKEVRLRPKIDPHDLGIKVKKARKFLEKGDKVQFSMLFRGREMIHVDHGHEMMKDILETIEDLAKVERPPKMAGRRLTMVVAPDGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD3</accession>
    <name>A0A1U9NMD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbgA</name>
        <name evidence="8" type="ORF">STSP2_02299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69112">
        <property type="protein sequence ID" value="AQT69112"/>
        <property type="gene ID" value="STSP2_02299"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010743018" evidence="4">
        <location>
            <begin position="21"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="345"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="734" mass="82336" checksum="54CB7DF4445BB095" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD6</accession>
    <name>A0A1U9NMD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68666">
        <property type="protein sequence ID" value="AQT68666"/>
        <property type="gene ID" value="STSP2_01835"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01835"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="308" mass="33531" checksum="B40DC1F914943DF8" modified="2017-06-07" version="1">MPKQAKLLLTQGRSNLDSGRPNAAIKLLRKAKAMCEDDKELMAEIYLEMAKVCEYVSREHEASVFFVKALRASSKIHEEAIGWVNQIKMGSNKKFAKDLDKLVKVKEVRKKLAEREEQQKARKAAVKEQPSQVPKVETEARKQTPPALPMSAISGQHAILTLLGGVLLSIGVFLPIIEMGVFKLSYLDFCIDGEGEAVVEGLIAIAMAGGAIVITVSKEWEFSWIPGVGALAVVAYRYFDLYTVKRQMQMDAMSDSGGDFFSEFATGIGSLMAESISVGIGGIIIGIGGVLLLAATATCPNYKAKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF9</accession>
    <name>A0A1U9NMF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68780">
        <property type="protein sequence ID" value="AQT68780"/>
        <property type="gene ID" value="STSP2_01953"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01953"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="24413" checksum="F975B773653BF7FB" modified="2017-06-07" version="1">MWRKKIDRIIPKVREEIENPSPDVSRIDNHDIFVLCQYLRGLGIPKNIDEDQLEDIFYHCYEQLEDILLDEDGDTLSEDEAWSQFIEVWPKIRIPKGFSFQKAVDKAKKMDTPLEIEIFSDERLILLGKVCYQLQLMVGDGLFWLSGYDAGKILGISQPRARRFLKTLVDQEILELVKSGNRRKASEYRYLPALEYEARTLDDTLGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG3</accession>
    <name>A0A1U9NMG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69025">
        <property type="protein sequence ID" value="AQT69025"/>
        <property type="gene ID" value="STSP2_02204"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02204"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="18031" checksum="4E5B11F93042746D" modified="2017-06-07" version="1">MKTNNENLKTLLNRFYDDASASQIEREIADGDELMSRFTSPHPSGQAVNNVKDLLGAELSGRRKRRYAFRVAGSVAAVLLIAISILFTTDTLNTRVEPEQSSSVYAFDSKSLDESELYAEFEEIEESFVQVRTGGWDASESDDLDELESEFDEIAGNFWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ7</accession>
    <name>A0A1U9NMJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02359"/>
    <dbReference type="EnsemblBacteria" id="AQT69172">
        <property type="protein sequence ID" value="AQT69172"/>
        <property type="gene ID" value="STSP2_02359"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02359"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="59865" checksum="FD9C1142B42DF730" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM7</accession>
    <name>A0A1U9NMM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69085">
        <property type="protein sequence ID" value="AQT69085"/>
        <property type="gene ID" value="STSP2_02271"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02271"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10363" checksum="54C1C892E612E64F" modified="2017-06-07" version="1">MQNNIFMDCITRHLSHQVRISKLQIKQQRPRFLLAMDFMARLVLLINDMPKGVFLNLNPRLINGREPHGVANVFTPNLFFFQKNLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT0</accession>
    <name>A0A1U9NMT0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69107">
        <property type="protein sequence ID" value="AQT69107"/>
        <property type="gene ID" value="STSP2_02294"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02294"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013138080" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32986" checksum="BB6AE37DBE03CF71" modified="2017-06-07" version="1" precursor="true">MKKFIMLLVLCACAAGVNAGTVAYWRFEDGVPGEQVQHGADPAQFSADISDVSGNGNHLSVWETQGGGSFGYRADVPYSTVPGTGAANDLSVKNTGGFPGMFTQTGSQISTMAPGTFTIEASFKIENGNYRTIIGRDSYGTVSDNSALAALYLQATPDNALAIKYSDVSGFWHEAVSENAIFESFDFGSDPTGSNVPWYSVSAVSDGSTLSLYLREAGAGVWDLIAETDIAASGSEDTALTAGAGDGGDWDAGNWTVARGLYDGWHGDRAWGFVDEVRISDEALSQSEFLVPEPATLALMGLGYMTLLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN15</accession>
    <name>A0A1U9NN15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-linked oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02178"/>
    <dbReference type="EnsemblBacteria" id="AQT69000">
        <property type="protein sequence ID" value="AQT69000"/>
        <property type="gene ID" value="STSP2_02178"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02178"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="47"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="479" mass="52643" checksum="678FC84139D4EC6A" modified="2017-06-07" version="1">MTDRTYSPVTNEILQELKAIVGERYVIAGDDDKLEPYSHDEVKGEQYAHMPECVVRPRKAEEIAEIMKLANREHVAVTPRGAGSGMSGGAVPIEGGIVLLMDRMNDIVELDKENMMITVEPGVVANDINEYLAEYDLFYAGYPMSLETCFIGGNVAENAGGGKAVKYGVTSRYVLGLEVVTPTGEIVELGGKLIKDVTGYNMIQLMVGSEGTLGVFTKIVLKLMPLPKSQVDLLCLFDSAEQAIECVPQIMTRSGIIPTAIEFMDRTAVRAACEYLNESIPYEQAGAMLLITVDGPSEEQVEHDYMQIGDQCMEAGASEVYVADNSTTSERVWKVRRNIGEAYNVISKRQCAEDIVVPPACIPAIVGKLGELSEKYDVMMPCFGHAGDGNLHARIVSPPEWSDEQWEPVAEKILNELYKFTAQCGGRISGEHGIGHKRKKYMSYFVSEGYLDMLRAVKRGMDPNNILNPGKIFDLQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN38</accession>
    <name>A0A1U9NN38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68926">
        <property type="protein sequence ID" value="AQT68926"/>
        <property type="gene ID" value="STSP2_02103"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02103"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013069839" evidence="1">
        <location>
            <begin position="33"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="840" mass="93041" checksum="40BCF1EF979A6104" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN62</accession>
    <name>A0A1U9NN62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M16 inactive domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02133"/>
    <dbReference type="EnsemblBacteria" id="AQT68956">
        <property type="protein sequence ID" value="AQT68956"/>
        <property type="gene ID" value="STSP2_02133"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02133"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="168"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="409" mass="44675" checksum="B9D6463B5D965991" modified="2017-06-07" version="1">MSSKVEKRVLKNGMVILGEHMDQVESAAFSFLLPCGESLLPEGVCGAGEVISDWLVRGAGDMDSRQLSDALEGLGLHHSEHVSSSHLTLGGVLESSNLIEALRLYGDIILNPKLDGEQFEMSKQLAMAHLAGLDDDPRQKVMLAVRERFYPYPLGRPAIGKEDELKALTADQARKIAQERVTPAGTIFAVAGKFDFAQLCSEMEALFSIDKPEPPTQANPGEKGPKYEHIEYPGAQVHLGMMTPAVTVDHEDYYKTLLMVSVLSGGMSSRLFTEVREKRGLCYAVGARYHALKGHAGVNCYAGTTPDKAQETLDVIKEEFAKLENGIDDEELASAKAGLKSSLVMQGESTSSRAGGVASDYYFLRRVREIEEIKAGIENITKAELETFLKENAFEDFTIVTIGSKELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN69</accession>
    <name>A0A1U9NN69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">STSP2_02245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02245"/>
    <dbReference type="EnsemblBacteria" id="AQT69060">
        <property type="protein sequence ID" value="AQT69060"/>
        <property type="gene ID" value="STSP2_02245"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02245"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="349" mass="39097" checksum="021FF841A7E7F6E2" modified="2017-06-07" version="1">MSEKKKVLIAMSGGVDSSVAAALLLKKGYECEGAFMVTNDHAQGACADAQQIAKQLGIILHVLDLRKDFENIIDYFCDEYRRARTPNPCVYCNREIKFGRLWKFALEQGCDFIATGHYIEIEHESDNAAIYETSNSAKDQSYVLAMIDKQVVPHILLPISSREKDQTRQLAAEFGFHIENKPDSQEICFIPDDDHIALLEERCPDLSRRGRIEDIDGNKLADHPGIHRYTIGQRRGLGVAMGKPAYVSKLDAQSNTVTLAEKPAVLKRELFGSGTNWLIDTPSEPFRAKVKVRYNHKGQTCTVYPDGDKVRVCFDEPVFAITPGQTAAIYVEQKGRWRLVGGAWIDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN76</accession>
    <name>A0A1U9NN76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69349">
        <property type="protein sequence ID" value="AQT69349"/>
        <property type="gene ID" value="STSP2_02538"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02538"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7642" checksum="79104DC8E9A2491A" modified="2017-06-07" version="1">MGLPKQVAIITRLTMLKNWILDLTFANSPVDCSGIWNNRKSNATFAAFSQTLQVKMTGMHNASWTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN85</accession>
    <name>A0A1U9NN85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliA_2</name>
        <name evidence="8" type="ORF">STSP2_02164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02164"/>
    <dbReference type="EnsemblBacteria" id="AQT68986">
        <property type="protein sequence ID" value="AQT68986"/>
        <property type="gene ID" value="STSP2_02164"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02164"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30495" checksum="6E64C8EFD8A84942" modified="2017-06-07" version="1">MVAVKSIKESKSDKQNKCGFFEKEGGQLGLDERNELLKKFLPLVRSIAAKVSSSTSSNVEFDDMVSVGVFGLMRAIDNYDPSREVHFSTYARSRIKGAMLDELRQSDWIPRHTRRQVNKYKRAKSKLVVDLGREPKQPEIAAELGKTMEEFRKWQYHLETTSLVSLDSLSGGSDDEDEKLGWLADPGGYDPSMPVQQEDSRNYLTKSLGKIERLIIKLYYYEQLTMREVGSILKISESRVSQMHSDILERLRERLGSNEEFYHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN99</accession>
    <name>A0A1U9NN99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Macrolide-specific efflux protein MacA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">macA_1</name>
        <name evidence="3" type="ORF">STSP2_02612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69422">
        <property type="protein sequence ID" value="AQT69422"/>
        <property type="gene ID" value="STSP2_02612"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02612"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="634" mass="70186" checksum="3F1C41BD37EEC1C6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP0</accession>
    <name>A0A1U9NNP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69509">
        <property type="protein sequence ID" value="AQT69509"/>
        <property type="gene ID" value="STSP2_02700"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02700"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7763" checksum="438577B9B7EC7960" modified="2017-06-07" version="1">MSENTKAAQITKAGWIDKHARSILMLWAGMQSPLDVDPNYLQHIKEELESCFEDPLKRSLIETSYPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR0</accession>
    <name>A0A1U9NNR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na/Pi-cotransporter II-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_02720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02720"/>
    <dbReference type="EnsemblBacteria" id="AQT69529">
        <property type="protein sequence ID" value="AQT69529"/>
        <property type="gene ID" value="STSP2_02720"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02720"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="372"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="568" mass="62766" checksum="04894EF7BE842DF3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW0</accession>
    <name>A0A1U9NNW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB_2</name>
        <name evidence="4" type="ORF">STSP2_02597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02597"/>
    <dbReference type="EnsemblBacteria" id="AQT69408">
        <property type="protein sequence ID" value="AQT69408"/>
        <property type="gene ID" value="STSP2_02597"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02597"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13850" checksum="ACFBC9043A735488" modified="2017-06-07" version="1">MNFGVSEKKESALRERMSKLDIVESDLEESFARSSGPGGQSVNKVATCVILKHKPTGHIVKMGKERSQLLNRYYARKRLCELIEEKRLGRKSPQARKAAKIRKQKQRRKRRTRKKLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW4</accession>
    <name>A0A1U9NNW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tolC</name>
        <name evidence="3" type="ORF">STSP2_02614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69424">
        <property type="protein sequence ID" value="AQT69424"/>
        <property type="gene ID" value="STSP2_02614"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02614"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002081" evidence="2">
        <location>
            <begin position="24"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="791" mass="87594" checksum="3665900CE5088FF6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP28</accession>
    <name>A0A1U9NP28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69702">
        <property type="protein sequence ID" value="AQT69702"/>
        <property type="gene ID" value="STSP2_02897"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02897"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34007" checksum="746583D6860A8605" modified="2017-06-07" version="1">MSSYLVTGGAGFIGSNICRRLVNEGHSVKVIDNLLTGKKSNLDDIIDKIDFIEGDMGDVELSKAAMKDVDVVFHQGALPSVPKSVDDPAATHKHCVDATFNVLLAARDSGVKRVVYAASSSAYGDSERLPKVEDMVTNPLSPYAVGKLVGEYYCKVFSEVFGLETIALRYFNVFGPYQDPTSQYAAAIPAFVTSILKGTPPTIYGDGEQSRDFTYIDNVVEANMCAANAEKTQGEVVNIACGDRITVNEIIKMINSITGQNVEPEYAPRRAGDVKHSHADISKAKEVIGFEPVCEFREGLDKAIDWYRDNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP76</accession>
    <name>A0A1U9NP76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ORF">STSP2_02736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02736"/>
    <dbReference type="EnsemblBacteria" id="AQT69544">
        <property type="protein sequence ID" value="AQT69544"/>
        <property type="gene ID" value="STSP2_02736"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02736"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28142" checksum="58ED04CEA81FA118" modified="2017-06-07" version="1">MTALRKKKKMHILLTNDDGIFSPGLFAIYKRLCEIAEVTVVAPAEVMSGASHSISLIPLTCDKVELTGKFSGYSIEGSPADCVKLGMTEIIKDKVDLVVSGINYGANVGIHVHYSGTVAAAMEGAFFGAPAIALSAAYEEDMDMDKISEYCASVVKKLLPLRPGDVMNVNIPRLSKGQPKGLVVVPHSTSGYEETYAAEQDSRGRVKYRITGGPARKEDLVTDVTSLSKGYITVTALHFNMTDEVRNADLKEIETHKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA1</accession>
    <name>A0A1U9NPA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02940"/>
    <dbReference type="EnsemblBacteria" id="AQT69743">
        <property type="protein sequence ID" value="AQT69743"/>
        <property type="gene ID" value="STSP2_02940"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02940"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19841" checksum="63F8F0B0203EAB44" modified="2017-06-07" version="1">MLGADDTCLVIVDVQEKLTAVMHERERLVRNLAILAEAAGLLRLPTVYCEQYPRALGRTVEELRGHLDAEEAVEKMAFSCMAEPEFVERLAATECRNVLLAGIEAHICVCQTAVDLLEKGYNVHLVTDAVSSRTAENRDIAIRRMESEGAVLSTTEMALFELLGTAEHEQFKRIAGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI9</accession>
    <name>A0A1U9NPI9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">adk</name>
        <name evidence="10" type="ORF">STSP2_03031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03031"/>
    <dbReference type="EnsemblBacteria" id="AQT69833">
        <property type="protein sequence ID" value="AQT69833"/>
        <property type="gene ID" value="STSP2_03031"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03031"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23361" checksum="56D878A9454D7FC8" modified="2017-06-07" version="1">MRIILLGPPGAGKGTQCKRIVDRYGLEHLSSGDILRAERAAGSELGKKAQSYMDSGGLVPDQLIVDMMIGAMKKAPKGYVLDGFPRTVVQAEELDKALQAADEKLDAVVNLEVPDEVVAGRMTGRRSCPECGAVYHIENLKPKVEGQCDNGCGELVQRDDDKPEVVANRLKIYHEQTAAVVGYYEKVGTEIISIDANQSVDGVTESVFKELDKVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK1</accession>
    <name>A0A1U9NPK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02962"/>
    <dbReference type="EnsemblBacteria" id="AQT69765">
        <property type="protein sequence ID" value="AQT69765"/>
        <property type="gene ID" value="STSP2_02962"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02962"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="21645" checksum="5BD024966749BEE5" modified="2017-06-07" version="1">MQGIGTNNSHNHPQNERIQRFLQLMSLNQSRIYGFVLSLTPQKTDADDIMQETSVTMWEKFDDFEQDTDFSAWGIKIARYKIMNYRQKHSGKNKQFYLSDQAIEVLESKSDKVFKHIDPRIEALRSCVKKLNSSDQTVLHLRYDNELPVEVMAERLGRSSKTIYRILSRIQDALIRCVRLTLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM4</accession>
    <name>A0A1U9NPM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tfp pilus assembly protein FimT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69871">
        <property type="protein sequence ID" value="AQT69871"/>
        <property type="gene ID" value="STSP2_03071"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03071"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="253"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="448" mass="49072" checksum="6BB41DED0AAFF4A1" modified="2017-06-07" version="1">MDSMAKIKKQLQTRTGMTLLEMTISISIMAIVMSAVLPQFHNVFSSWESRRNTAELIQNGRVLHEHVNRLLREAVKITEMSSPDSNAGYIEFETSAGEEYRYELAENGYVRYGLNGSMHDLAGPVDSFNIKCYEKSISTTPLTDPDLVRFIKVESRFDNARQNARGRNFKSCISLNADNNPNDSLIHHWSFDDPTGKKLSDSVGSLHGHAGNQVTMGQPSARNDLDSSINLNGDIEKSKVDLRKANDLRKLTKNFTISAWVRPEPMGEKAVIIGPSENLHGWSLSLSDGWLVFTVMPEEEHWADANVPLYQWSHVAMVFDGACNISFYLNGELTASAAADGPAATIGGNKDWTIGQANEQNPFKGNLDDIKIFDTALNPQQVAFVYKLANPVAPNGNNGNGNGSNNGNGNDKSNNGNNNPPEPNENSGSGNNNGNDNNNGKANGKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM5</accession>
    <name>A0A1U9NPM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C_GCAxxG_C_C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02933"/>
    <dbReference type="EnsemblBacteria" id="AQT69737">
        <property type="protein sequence ID" value="AQT69737"/>
        <property type="gene ID" value="STSP2_02933"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02933"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="15942" checksum="E083A9BED80872B2" modified="2017-06-07" version="1">MASTRQDQAVELFKSGYNCAQAVAGAFAPDVEIDRDTALRTAAAFGGGIGGTGKTCGALSGLLIVLGCKYGRREPADMQSKAEMVNISQQAIKIFIEQTGARDCRDLLGFDLAAKEGKAAASKDNAFDVCPDLVRTAAEIAEKLLQDDQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX6</accession>
    <name>A0A1U9NPX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69959">
        <property type="protein sequence ID" value="AQT69959"/>
        <property type="gene ID" value="STSP2_03159"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03159"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13072" checksum="537F03A9AC6EC846" modified="2017-06-07" version="1">MSDFETLVKDAEAKAMTKVGGEITATPAGGDAITISSAIVGPADKVRSYDQQGNQTVERRSVTILRSEWNSPAIDDTLTIEGASWRIDDIDEQDFSITTVTAVKTTDNARHSDGHFVRAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ0</accession>
    <name>A0A1U9NPZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rpsL</name>
        <name evidence="8" type="ORF">STSP2_03055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03055"/>
    <dbReference type="EnsemblBacteria" id="AQT69857">
        <property type="protein sequence ID" value="AQT69857"/>
        <property type="gene ID" value="STSP2_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03055"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13306" checksum="821BA080792B8DEB" modified="2017-06-07" version="1">MPTINQLVRRGRGRKAKKRVSDITGCPQKRGVCLVVRTQTPKKPNSALRKIARVRLTNGKEVTAYIPGIDHNLQEHSTVIVRGGRVRDLPGVRYHIVRGSLDTAGVDGRKQGRSKYGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ07</accession>
    <name>A0A1U9NQ07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble hydrogenase 42 kDa subunit</fullName>
            <ecNumber evidence="4">1.12.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03105"/>
    <dbReference type="EnsemblBacteria" id="AQT69905">
        <property type="protein sequence ID" value="AQT69905"/>
        <property type="gene ID" value="STSP2_03105"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03105"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40820" checksum="7C5C1FFACFDF82F4" modified="2017-06-07" version="1">MTDWKNPPRLFIPGPVKVDEDVLQQLARPTLGHRLKEYVQLHKETVDMLKKILYTDQNIFLSSSSASGIWEASIRNCVQMDEKVLCTMCGAFSDKFASITRSCGREADELKVDWGQAITPEMVDEKLASGNYTAVTMVYNETSTGVANPVYEISEMLREKYPDVLVFVDAVSGMVGLPIHFDKLGWDVVFASVQKAWAIPPGLTVAAVSDRALEKAKEVPNRGYYFDFLEFAKRAEKHQTPTTPAIPHIMALHYQCTKLLDEGMENVWKRHKEMGDFVRAWAKENFALFAPEEYVSDTLTTIKNTKGIDVAAVNNALQEKHNTVFGNGYGKLKNETFRIAHMGDINMADLKELLGWIDEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG5</accession>
    <name>A0A1U9NQG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03185"/>
    <dbReference type="EnsemblBacteria" id="AQT69984">
        <property type="protein sequence ID" value="AQT69984"/>
        <property type="gene ID" value="STSP2_03185"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03185"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="398" mass="43191" checksum="C62B863D15ECC92C" modified="2017-06-07" version="1">MTALNGRSILLFAFVFMFCGSGFCDVVESEGNRGGWVRVYSNGNFSDRNPRIIMAEDGGLYLVVSESKWTGNSLTYNGLWIWKLDANGQREWVKEITGPEIEHVRSWDSDVVCPEKERVIVASSGSETWMIGFDEAGESKIIGRVGEAGNSYAMRSMAKLKGGYLISGQKMGDEVDAWVTKIDETGKTLWEKTYDRGKEEFAWSMAVGEDGSFVIAVDSGEYDKFGAGPSEALLIKCDKDGKILKEVNFKGRHAAVGMSSTGDYAVCHNRGQFMNFKMRVRGYDSDLNLKWDDVELYDGMGLGMYLMADGGDGFAVAGTKLGGGCWVWMVGSAGEIVESRKIADGPAGVDSFVGSGDGYLMASSVSIERASAGEGAVGPLRILVEDEEDLVVAKIVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI7</accession>
    <name>A0A1U9NQI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69880">
        <property type="protein sequence ID" value="AQT69880"/>
        <property type="gene ID" value="STSP2_03080"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03080"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12289" checksum="D85AF92C345BC27D" modified="2017-06-07" version="1">MTASSKSRMSLEQYLEKVARFVGDEYGRQVRRQFGDNRGSGELGMLESPSHEELEQIRRAVAIMTPEEKANATSLTDEQVERIAQDAKVDEAVFAIFINGYSLECKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK4</accession>
    <name>A0A1U9NQK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS family inner membrane protein YnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ynaI</name>
        <name evidence="8" type="ORF">STSP2_03215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03215"/>
    <dbReference type="EnsemblBacteria" id="AQT70014">
        <property type="protein sequence ID" value="AQT70014"/>
        <property type="gene ID" value="STSP2_03215"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03215"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="42944" checksum="EFAAB16D6BECBF26" modified="2017-06-07" version="1">MDFIVGQVDSWWNILDYELVRGNGVWRFMLVLLGIIGTFVVAMLFQYFANLHVKHHKDMEERRFLSLVLQAIVKPAYVGIFAIGLNVCKVFLYFNEENGIKPAIEAGWTKTAQVVGAVAVAYALYSLVDVAEYYLNRLVRRTKTELDDMLVPLLRKSLRVTIAIIAALYVAENTVGTDHIKSLLVGAGIGGIAIAMAAKDTVANFFGSITIFADRPFQLNELVEIEGNMGFIEDVGFRSTRIRTLDGHLVTLPNSIVTNSVVINIGNRPHIRREFEITITYNSGSMKTAEAVDIIKKVLAETPEVNTDTENPSRVYFSEFASCSLNIYIVYWVVPADRWVFREVNERVNFEIMKRFEQAGIEFAFPTQTLYLKKDDGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU6</accession>
    <name>A0A1U9NQU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvT_1</name>
        <name evidence="3" type="ORF">STSP2_03361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03361"/>
    <dbReference type="EnsemblBacteria" id="AQT70157">
        <property type="protein sequence ID" value="AQT70157"/>
        <property type="gene ID" value="STSP2_03361"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03361"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="32"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="46504" checksum="D7987F9BCFEDE8DC" modified="2017-06-07" version="1">MTKTSQRFEFAAADAEPRKSALYDQHCRLVPQSRIVPFAGYVMPVRYSSIKDEHEAVREAAGVFDCTHMGVLEFAGPKAADFLDMVTVNNVQKLSSGRAQYSQVLDGTGNILDDIIIYCRREDLFMVVVNAVNNEKLKAWFGGIISGDIEVDHPDAPAIDPMPSMRDLRDPASGEDQRVDIALQGPKAADIIGEMMEDEAAGGQLAEMKPFRFIETSIAGNDVIVSTTGYTGSPGFEIYVHPETAGQVFELILEKGEKYGVKPCGLGARDSLRIQAGLPLYGHELSGKHAISPLEVGYSWAVKLDKPFFIGKDAMLENDKNRTMKVVRLSLPGQKGVRPVREDDGVLTEDGECIGWILSATKVGEEQIALAFVSRDAVKKEDPVGVYYLARSQGQKAKGKLDSVEPGQELEADITGTVEPRFARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW3</accession>
    <name>A0A1U9NQW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03527"/>
    <dbReference type="EnsemblBacteria" id="AQT70321">
        <property type="protein sequence ID" value="AQT70321"/>
        <property type="gene ID" value="STSP2_03527"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03527"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16011">
        <property type="entry name" value="CBM9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="25516" checksum="15A7148A9CBD2FF3" modified="2017-06-07" version="1">MKRYVVKRVSERPGLCGEWDKGLWGGVEAAEIDSWLGGEDRDRPCARVKAVYDEGAIYVNFRVEDKYVRAVARGYHGPVWEDSCVEFFFTPGEDVSEGYFNVETNCGGTMLFNRQKERGVENVAVGEADCDKVEIYHSLDKIIEPEIKEEVVWSLQYRLPFEVVRKYAPSFDEPGEGVKWRANFYKCGDETSRPHFMTWNPIVVEEPDFHRPEFFGELVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX6</accession>
    <name>A0A1U9NQX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">exo I_6</name>
        <name evidence="8" type="ORF">STSP2_03116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69916">
        <property type="protein sequence ID" value="AQT69916"/>
        <property type="gene ID" value="STSP2_03116"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03116"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143332" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="7">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="861" mass="98001" checksum="6FB0136FE715A08D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ4</accession>
    <name>A0A1U9NQZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">strE_2</name>
        <name evidence="2" type="ORF">STSP2_03547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70341">
        <property type="protein sequence ID" value="AQT70341"/>
        <property type="gene ID" value="STSP2_03547"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03547"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35600" checksum="F7BCAAC8BEFB63E8" modified="2017-06-07" version="1">MNILVTGAAGFIGSHLTERLLADGHTVVGLDNLDPFYDMAIKRQNLSNFNQHENFTFVLGDICEPEDVERACTEQKPDMIVHLAAKAGVRPSILAPVPYHQVNVEGTTVMLEAARHYKIPKFIFASSSSVYGNNEKIPFAETDNVDYPISPYAATKKAGELICYTYSHLHDIDITCLRFFTAYGPRQRPDLAIHKFARLILDDKPIPVYGDGSMRRDYTYIDDIIDGVRAAMDRCSGYNIYNLGESQPIRLDELIAELENALGKKAIINRLPLQPGDVNQTYADVTKAKLELGYHPTTELSVGLKRFADWLKNTNTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR07</accession>
    <name>A0A1U9NR07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70158">
        <property type="protein sequence ID" value="AQT70158"/>
        <property type="gene ID" value="STSP2_03363"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03363"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="477" mass="53343" checksum="FDEFE9C2434CC868" modified="2017-06-07" version="1" precursor="true">MSKVWKIWIILFVTAGVLGLATSGAVTLVKKSAAASYQQKFPEGTEKHLENYEEILDLAHQPELTEEQLRLFQEKKNELASEQEDLLKADLWDLATGKKQPSVIADFMYGQGWQEKVKTEKTIHAGMEILAIVSTVSLLTGLIVAAGVGVKVATGSARSKHKAKKEVKKANKAAPKLQKDTSKKAAPVERPQEAKPSQKSEDDTEEDEASEPKKKPGLLKAVKTDSAKEHKTQRQRNFEKYKAQKSKEDDLKAQAETSDQKSVEPQDEKPKVGAFSSQRLKQAGLTGVRFGNNSDESTQGGLSQQVAKLQNMMSTAPVKESISELTEQMSAIREFASQQQDRFRQLQDGYDWNIIKRFCLRIIRCIDNLDARLDYLAAEEEDTSDLEEVRDELLFALESSGVEKFTPDLLADYKGLERYAEAVSQREMTEDEDLVGKVAKVVRPGYQYILNDNEIKVVRTAQVKLYSQKLTAVSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR49</accession>
    <name>A0A1U9NR49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator KdgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdgR</name>
        <name evidence="5" type="ORF">STSP2_03197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03197"/>
    <dbReference type="EnsemblBacteria" id="AQT69996">
        <property type="protein sequence ID" value="AQT69996"/>
        <property type="gene ID" value="STSP2_03197"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03197"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27177" checksum="A8B2ECFD9353E04B" modified="2017-06-07" version="1" precursor="true">MNNYIIPNLSKACRMLSCIAASDKGMTAAQIEQTLAVPKTTAFRILRTLCHEGMVTKNGGTYHVGPTLLELSGRAISSVNVRDQAVPVIQELAQTTGQTAHLAIPSGTSSLILEVCDSPNPVRVASRPGTLVSMHCSSTGKVFLAYLFKDRLAQTLADVKLEHRTANTKCTVADLQAETEKIRQLGYATDDEEYHTGVRCLAAPVFDGRNQVVAALGITATTSSFTPERTQELAALVVGAANKLSKKLGHNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRA3</accession>
    <name>A0A1U9NRA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pimB_4</name>
        <name evidence="1" type="ORF">STSP2_03541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70335">
        <property type="protein sequence ID" value="AQT70335"/>
        <property type="gene ID" value="STSP2_03541"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03541"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="397" mass="45021" checksum="ABCB5EE848C4A1E4" modified="2017-06-07" version="1">MRVMVALENRFIRTANGNIYSTTVCDYDFWKRYLQVFEKVIVLARVATSPEISLNKLQANGPGVEFFELPSFIGPWQYLKNRHRVESLVNAAVEQADAYILRVPGTVATLLWKALMKKSISYGVEVVGDPQASLGPGTVKSAIRPYIRFLMTRNQKLQCKEASAAAYVSESYLQKDYPSCGWSTHYSSIDLPADAFISKEELESKRIGGQLSNKPLRLCHIGSMSALYKSQDMLIRVVEICRKRGLDVCLHLLGDGAYRSKFEKEARDHGVKDYIFFDGRLPPGQPVLKWLDQGDIFVLPSLTEGLPRSMIEAMARGLPCIGTNVGGIPELLDEEYLVPPSNCHLLANKICNYAENPNKLAKMSLENWQKAREYEHENLNKRRIDFYNHLKLNTEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRE1</accession>
    <name>A0A1U9NRE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70304">
        <property type="protein sequence ID" value="AQT70304"/>
        <property type="gene ID" value="STSP2_03510"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03510"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29922" checksum="72EA980325B976E4" modified="2017-06-07" version="1">MEKVSFLDYLSLPWLFAATFILVLLALSTGVFWGRFKAKRPEHEPDSSVGPAVGATLAMVGFLIAFAFALSNERLETRKQLLLDEVNAIGTAYLRTHLLEDPYGREIKKLLEKYVDIRTLVADEAVRADPEKMKQLIARSEQLQDLMWLQTKKMVEADNKSPVEAVFISSLNELFDLHTSRVVVTRYRFQAIVWYIIYVAMILSMLAVGYQMGLSGRGSTLIVIAVALTFSAILLLVVDLDRTSTGTMVVNQGPMLELQKTMQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS36</accession>
    <name>A0A1U9NS36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(Dimethylallyl)adenosine tRNA methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03532"/>
    <dbReference type="EnsemblBacteria" id="AQT70326">
        <property type="protein sequence ID" value="AQT70326"/>
        <property type="gene ID" value="STSP2_03532"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03532"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="295"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="631" mass="70774" checksum="F0A9F46EA7B84B1E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG59</accession>
    <name>A0A1U9NG59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66913">
        <property type="protein sequence ID" value="AQT66913"/>
        <property type="gene ID" value="STSP2_00051"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00051"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="18230" checksum="5B141C63FE7BFD56" modified="2017-06-07" version="1">MENNKSKSYQKGLELAEQGKHDQALELISEHLETSPDDLEALNDKGAILFCMGKTDEAIQHFEQARQVDEDCPQVYWNLAEAYLSANRPEQAKKQFEKMDRLSILNCDLLNRTANQFLQNENCEQANEMLEWSLKMTPDQEILKPMIEIIQSRQNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGA3</accession>
    <name>A0A1U9NGA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terminase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00099"/>
    <dbReference type="EnsemblBacteria" id="AQT66961">
        <property type="protein sequence ID" value="AQT66961"/>
        <property type="gene ID" value="STSP2_00099"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00099"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="1">
        <location>
            <begin position="339"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="57214" checksum="5CCA266D94877889" modified="2017-06-07" version="1">MGRDVEVGRANRIYEDLRMIRPAGRSDIKNYIKVFLGVDVPDVRVCGDHDTPMDYLWHCWSADKSTGKTNADAMLISADDANMASDDNAGANGDAVVWANRAGGKTHIAAIATLLDCLFKPGCDVRILGGSGEQASRMYDYLVGFLGRGFEQFVDGRILKERCQFINGSKVQVLTQSAKSVRGSHVHKLRCDEVELFDRDVFEAAKFITQSTKGIKAAMEVISTMHRPYGLMGEVVSSAKEMAVPTIKWCMWEVIERCVSRSCSTCPLWGYCGGKARHADGYLKIDDCITQMKRSSKAGFESEMLCRRPSIENVVFADFEPAVHVKPVAYDPDLPLYRTLDFGFVNPFVCLWLQTDAEGNVRVIDEYQRSRATIASHAEQLKQRTPCREEQVAATFCDPAGAGRNDVTGTSPVRELRAYGILTKYRRSGILEGVELIRRALRRGDGKSSLVIDPRCVRLIEAMQCYHYPDDVRRRGAELPDKDGVYDHHIDALRYFYVGLKHNSGAMVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ2</accession>
    <name>A0A1U9NGJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67061">
        <property type="protein sequence ID" value="AQT67061"/>
        <property type="gene ID" value="STSP2_00201"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00201"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13624" checksum="0B8CA68C92218F2B" modified="2017-06-07" version="1">MVFVAGLRSYMRWLAMTPLLLHGVEPLRLPAHSPDLNAYAERFVRSVKSECLDHLILSSVEQLEYVLDEYINYYHHERIHQSLGRIIEPKHQLDETAEIQCIERLGGLLKSYHRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU5</accession>
    <name>A0A1U9NGU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-D-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67149">
        <property type="protein sequence ID" value="AQT67149"/>
        <property type="gene ID" value="STSP2_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00290"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143321" evidence="3">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="4">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="5">
        <location>
            <begin position="414"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="643" mass="71455" checksum="B37D671FA808F320" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH39</accession>
    <name>A0A1U9NH39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">recQ</name>
        <name evidence="12" type="ORF">STSP2_00227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00227"/>
    <dbReference type="EnsemblBacteria" id="AQT67087">
        <property type="protein sequence ID" value="AQT67087"/>
        <property type="gene ID" value="STSP2_00227"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00227"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="211"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="525"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="609" mass="68289" checksum="2F5EDDA5C1F7F2ED" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB0</accession>
    <name>A0A1U9NHB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Memo-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00275"/>
    <dbReference type="EnsemblBacteria" id="AQT67134">
        <property type="protein sequence ID" value="AQT67134"/>
        <property type="gene ID" value="STSP2_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00275"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31650" checksum="9EA523054B263EE2" modified="2017-06-07" version="1">MEARKPAVAGQFYAGSSKGCLAEVEECISVRKIKTELPGPIIGGIVPHAGWVFSGDLAGMVFSAVRQVNIDVDTFVMFGAVHTYLNKYAAVYDSGRWATPMGEIEVDEELANAIIDDTSCAVADKDIHRGEHSIEVQLPFIQYLFKDAKIVPIMVPPTEFSLELGKNVGEIIKGIGDRKKIVCIASTDLTHYGPRYGYTPQGTGKKALQWAKDTNDQEFIDLATSMQGRQLLIKAEEDWNACGPGAAAAVVEACAAQGREKGVMLAHSHSMEVMEAKFGETGDESVGYAAIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB1</accession>
    <name>A0A1U9NHB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar assembly protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00034"/>
    <dbReference type="EnsemblBacteria" id="AQT66896">
        <property type="protein sequence ID" value="AQT66896"/>
        <property type="gene ID" value="STSP2_00034"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00034"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="59"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21153" checksum="27A1081A13003EAD" modified="2017-06-07" version="1">MPEPITLNLKVPVASVELANPGEDGQDDALGDPSEIKARLAEIENIKAELTAEKQQIGQALAAIEKSGSELEQFYQQSMNEYPAQVVGLGVEIARRILAGKIEAGEYDIEAIIERAVDAAPVKEDITIRLNGKDIETLTANGAENVGRLKGVKLVADDSIGRAECVVDTPRGIVDYFVEDQLKRIVDIILNTASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB9</accession>
    <name>A0A1U9NHB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00452"/>
    <dbReference type="EnsemblBacteria" id="AQT67309">
        <property type="protein sequence ID" value="AQT67309"/>
        <property type="gene ID" value="STSP2_00452"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00452"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="37412" checksum="DDC064DA960E5AD3" modified="2017-06-07" version="1">MKLARITRIVQILTYLQSGQKYSVDQLADLMGVSRRTIFRDLNQLEAIGIPFRFDSEVHGYTLDPEFFLPSIDLNLQEALSLLMLVQKGRSHLPLPFKNSALLAGIKIENNLPAEIKSYCNSSLENISIRPHNHAPMDQLDSVFAAIQRAIKAKRKLKMAYFSLYDGGDIELEFSPYHIFYNHRAWYVVGYSSIHDETRTFKLNRIKQLSVLKKRFIDGDKFDIAEYFGRAWSMIREGKVYNVTLRFSPRVARNVSEVRWHVTQQHSFNEDGSLTANFRVDGLNEIKWWILGYGDQVEVIKPAKLRKEVARAGAKIAKLNSDPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD4</accession>
    <name>A0A1U9NHD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FlgN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66916">
        <property type="protein sequence ID" value="AQT66916"/>
        <property type="gene ID" value="STSP2_00054"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00054"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19233" checksum="E5A15A29881149D7" modified="2017-06-07" version="1">MNANGNLYQLADELIEVLDEDIRHLEGSLERLDTLRAMTITRDETGLNELLETIRIQANRYSAVEQKRQQLRTQIAALLGSSFDDTDLSLIAKALAGEKSQAVKTRQDRLAELVGKMNVEHAATAMLLAECSRFNQQILNSILCTKSSEGTTYSRQGAKNENRTSGMMNMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE4</accession>
    <name>A0A1U9NHE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate hydrogenlyase transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fhlA</name>
        <name evidence="8" type="ORF">STSP2_00064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00064"/>
    <dbReference type="EnsemblBacteria" id="AQT66926">
        <property type="protein sequence ID" value="AQT66926"/>
        <property type="gene ID" value="STSP2_00064"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00064"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="135"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="49826" checksum="E9FDD166ED294EFE" modified="2017-06-07" version="1">MGLNRILVLGRDSRIQQLAATMADAVFAADSIGEAWDITDRSEPEAMIVDPSISDADTCRALKYVETNDLMPVIIVRDDAEEETVNDFLSLGAFACIDAVKGLDKLGLVVDRIADGENGGQSEYFDSQCPPCVQMVGKSEATVKALKMIRLVASSGCDPILVVGETGTGKEVAAQAIHNLRHGSDETFVAVNCAALTANLLESELFGHVKGSFTSAESEKTGLFEAADEGTIFLDEISEMPLELQAKLLRVIQEKRFRKVGGTKEIQCKATIIASSNRNLNDEVENGKFRRDLFYRLNVFPVALAPLRHHDRKDDIELLAKFFIENSTVAPDKAAKIKGLTKLAIESLKNHSWDGNVRELKNVIDRAMLLETTDKIGCSSLIFDPTDFSSAKSASPVENIQDFSLANAEKELIDRALKEAKGQKTRAAAMLGITRATLYAKVKHYNIDADAGKVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP9</accession>
    <name>A0A1U9NHP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">prs</name>
        <name evidence="8" type="ORF">STSP2_00469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00469"/>
    <dbReference type="EnsemblBacteria" id="AQT67325">
        <property type="protein sequence ID" value="AQT67325"/>
        <property type="gene ID" value="STSP2_00469"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00469"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="317" mass="34697" checksum="7CAD217CD43428A3" modified="2017-06-07" version="1">MNVNNEIKIFGGSSNPELTKAICKYLDLDQGKAKIAPFPDGESFIKIEDDVRGRDCFVIQSTCAPVDGNLMELLIFLDCLKRASARRVTAVVPYFGYARQDRKDEGRVPITAKLVANIISTAGADRVLSIDLHAQQMQGFFDIPVDHLMAEPVLVKYFKEKELKDLTIVSPDVGNMKTAARYARELGGDLAIIHKKRINGKEIEAEEIIGSVEGRNVLMCDDMISTAGTMCGAAKLVRERGAKNIIAGATHGVFAGPAVERINAAPFDEVIVTDTIPLSDDVKKIKNLKVLTVSKMLGEAIKRIHCNESISCMFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU3</accession>
    <name>A0A1U9NHU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67493">
        <property type="protein sequence ID" value="AQT67493"/>
        <property type="gene ID" value="STSP2_00641"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00641"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029037">
        <property type="entry name" value="YfgJ-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11592" checksum="14740FC9A0CC199D" modified="2017-06-07" version="1">MRINHNAYKSCGECKKFPCDKTKNFHKNGKDFALVAEMNCYTLTGLDYKKWLKAQKTRWTCSKCGESFSNKSEKCPKCGKDIYSLKEEAQAYRQFRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV3</accession>
    <name>A0A1U9NHV3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsF</name>
        <name evidence="7" type="ORF">STSP2_00472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00472"/>
    <dbReference type="EnsemblBacteria" id="AQT67328">
        <property type="protein sequence ID" value="AQT67328"/>
        <property type="gene ID" value="STSP2_00472"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00472"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17679" checksum="72DCAE772D31CCDB" modified="2017-06-07" version="1">MATDKKRLYEGMFLVDSALAAADWNAAIGAVERVLSRAEADVVSLKKWDERKLTYAIKGKVRGTYILTYFKCDPEKLSPMERDVQLSEEIIRALFLKTDKMSDEDINQLTPLEQAEKEEAEAQKAKEEAMAKATAVEEEPAAEGSEGSADTAQTEEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV4</accession>
    <name>A0A1U9NHV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00670"/>
    <dbReference type="EnsemblBacteria" id="AQT67522">
        <property type="protein sequence ID" value="AQT67522"/>
        <property type="gene ID" value="STSP2_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00670"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15068" checksum="DC7716CC9E391E83" modified="2017-06-07" version="1">MKIYDEVVDVRTNKRNDMIDITAKVRDVVVKSGVANGDCIVFCKHTTGGVTINENADPDVVHDVLLTLDELVPEHRTGYRHGEGNSDSHVKSSLVGCSEQVLIKDGRLVLGTWQGIYFCEFDGPRSRKVVVQVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI13</accession>
    <name>A0A1U9NI13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR repeat-containing protein YfgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yfgC_2</name>
        <name evidence="10" type="ORF">STSP2_00602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67455">
        <property type="protein sequence ID" value="AQT67455"/>
        <property type="gene ID" value="STSP2_00602"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00602"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012753014" evidence="8">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="74"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34573" checksum="83A9D70AC0F2978E" modified="2017-06-07" version="1" precursor="true">MNLRNCLLALVLALILPTLTACTEAPITGRSQFIMVSDASMLSASQESYAEFLETNELSDNTEQTAVVKRIGKDIQNAVETWAQDTGQTDLLENYEWEFNLVQSDQVNAWCMPGGKIVVYTGMFPVAETEAGLATIMGHEVAHAIARHGAEQVTSNMVVGAGGALLAAAFNDDEPGDPNSTDGGYSDEQIAMISYGILTQVGLLLPHSRTQEREADHLGLIYMAMAGYNPEKAPELWQRMADRGKSSSGLLKSFETILSTHPTNEERIINLRDLAPDAMRYYRNAPTRHEDKKLPLTPEQTAETEPADAQTPEPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI50</accession>
    <name>A0A1U9NI50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore protein SP21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hspA_1</name>
        <name evidence="4" type="ORF">STSP2_00423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67280">
        <property type="protein sequence ID" value="AQT67280"/>
        <property type="gene ID" value="STSP2_00423"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00423"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18895" checksum="B89118347009EEEC" modified="2017-06-07" version="1">MTLYELMPRRKRGGSQVASGQADPFYALQKRTNDLFRDFFSDFGFEPMTEAGRWAKEFTPSINVSETDKAYKISAELPGMDENDIDVSIEGDSLLIKGEKKAEDQEEGENWFRSERSFGQFQRAIGLPVDVDEDKIEAEFKKGVLNVVLPKTEEARTKSKKISIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI68</accession>
    <name>A0A1U9NI68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdsA_1</name>
        <name evidence="2" type="ORF">STSP2_00771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.41" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00771"/>
    <dbReference type="EnsemblBacteria" id="AQT67623">
        <property type="protein sequence ID" value="AQT67623"/>
        <property type="gene ID" value="STSP2_00771"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00771"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31213" checksum="81CCD0641398D8A7" modified="2017-06-07" version="1">MLKYRLIFGTLMIAAFLGLLIFDAWLDGSLLADTENLPIQASILAGLLAGLAIPATFELSHLLANVGAKVFKPLTIILTALMATNWYWAQFYTDPAQFQLYYLLFTSAFAVLGVFLYQGKWFGTSDVLKNCSANLFCIFYLGLLSSFVLGIRIEFGVWALLMFVFVVKSSDIGAYTAGKLFGKHKFAPRISPGKTWEGLAGAIIFAAIVSFIFGYCCDIMAPWSAVLFGIVFAVCGQLADLAESMIKRDAQQKDSSAVVPGFGGVLDVIDSPLGTAPLAYAFLMFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF9</accession>
    <name>A0A1U9NIF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">obg_1</name>
        <name evidence="3" type="ORF">STSP2_00439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00439"/>
    <dbReference type="EnsemblBacteria" id="AQT67296">
        <property type="protein sequence ID" value="AQT67296"/>
        <property type="gene ID" value="STSP2_00439"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00439"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36834" checksum="92ECF24F74D42B4C" modified="2017-06-07" version="1">MPANLTPDYFKAEKWFKSASTDEERILALEEMLRVIPKHKGTDHMRADLRKKLSKLRTAVEEGGKKGGKRTDIFHVPKNGAGQLVLVGTPNCGKSSVVAAVSKASVNVTDFPFATQTPVPGMMYHEDVQIEIVDMPPITPDYAPAGMVNTYRNCDIIGIVIDVAADPLEQMEVCTEYLQSHRLLPDENTDEQDEQGNRLARKTIVICTKIDAAPDGTIETLAELTERDFEYLPFSAHTGEGLHEMVARVFELLNVVRVYAKKPGKEPDMKEPFTLDKGSTVEDLAFTIHRELAEKLQSARAWNAPDIHDGQNVQKTHELTDKEIIELHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG0</accession>
    <name>A0A1U9NIG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67713">
        <property type="protein sequence ID" value="AQT67713"/>
        <property type="gene ID" value="STSP2_00861"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00861"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10570" checksum="C8CCD91D2BB6C3F9" modified="2017-06-07" version="1">MSPKQKRKAKKDMGKYIPPEQRDILERKPILYHEIKTREHLYDMAHTTKERTERFHELTNIKGVPNQVAEEIVLNDYFYLPESPFIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK6</accession>
    <name>A0A1U9NIK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
                <ecNumber evidence="16">4.2.1.59</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Beta-hydroxyacyl-ACP dehydratase</fullName>
                <shortName evidence="16">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
                <shortName evidence="15">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
                <ecNumber evidence="15">3.5.1.108</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lpxC</name>
        <name evidence="16" type="synonym">fabZ</name>
        <name evidence="17" type="ORF">STSP2_00480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="14 16">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LpxC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="16"/>
    <dbReference type="EC" id="3.5.1.108" evidence="15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00480"/>
    <dbReference type="EnsemblBacteria" id="AQT67336">
        <property type="protein sequence ID" value="AQT67336"/>
        <property type="gene ID" value="STSP2_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00480"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="436" mass="47850" checksum="7838D879B97AD6B0" modified="2017-06-07" version="1">MKAQKTIKSEIKLSGKGLFSGKDVKLVFKPAEPDTGIVFVRTDFEQPIKVPVAAANITEVQRRSALKKGPATIETPEHCLAAINAMGIDNITIEIDSVELPGFDGSSDEFYKTLRKVGVEDQPEAPSREFVIKEPVSVIDGDTSIHAVPSEEPGLSITYDLDYTQHTGIGRQLYSCNLNTDHFERELANARTFCLEAEARQMQAHGIGTHLTPKDILVINSDGPIKNNYRYPNECVRHKIVDLIGDLAFVGRPVSGRIVAYKSGHAVNQKLAKKLAKLARETEKAAASERAVLNIRKIQRILPHRYPFLLVDKVIDIEGDSKITGIKNVTINEQFFQGHFPGTPVMPGVLIVEALAQVSGLLFAQKLEHTGKLAVLLTMDAVKIRKSVVPGDQLILCAQANRVRGRSAKCDCVAKVGDEVVAEAVLKFMLVDEDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK7</accession>
    <name>A0A1U9NIK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_7</name>
        <name evidence="5" type="ORF">STSP2_00726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00726"/>
    <dbReference type="EnsemblBacteria" id="AQT67578">
        <property type="protein sequence ID" value="AQT67578"/>
        <property type="gene ID" value="STSP2_00726"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00726"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="55577" checksum="203A95D12FB314F7" modified="2017-06-07" version="1">MDRRDFLKLAGVTAGAAGLNMSFASAKLARAEKRKPNVIYIMLDELGYFELSCMGNEKVHTPNIDRMVSEGMRFTQMLAGSAVCAPTRSVLMTGKHAGHTTVRVNGGGLALLEDDATIASMLKCAGYATGGFGKWGLGDAGTTGVPEKHGFDTFYGYYHQVHAHTYYPRYLLRNSEKEYLPGNTDDFYEGETFAHYKIFEEAKKFIKSNADKPFFCYCPWTPPHGLWGMPEDDPSWQMYEDKPWRAGQRQPTDSRVYAAMINMVDRQIGEIMDMVKELGIDEDTIIFFCGDNGGQPYFCWGDPSTPRPEKMPYPHGFIGPNLNPETGERFRGGKGNLYEGGLRIPFIVRWPGKVEAGSVSEHLGYFPDVMPTLGEICGADVPTDTDGISFAPTLCGEKAAGREQDEHEYLYWEFGRWIAVRYGDHKLVTRRNNKGRAELYDLSEDIEEQNNIAAEKPDVVKKLLAFADVAHTKNKVGTYLPGTEDIRFDGLKVRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT9</accession>
    <name>A0A1U9NIT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein YtrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytrB</name>
        <name evidence="5" type="ORF">STSP2_00658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="33023" checksum="80A6B268BCDCB46C" modified="2017-06-07" version="1">MSGNVIVEMRDVVKWFGHVQALDHVSLDVRRGEIIGLLGANGAGKSTLLRCVIGLYLADRGTCRTFGVDAAKLGAVELGRIGYVHQEGELLDWMTVGQLIRYVSAYYDTWDRELEERYVADFDISLRDRVGALSPGQRQKVAILLAIGFGPELLILDEPASALDPLARRRFLDMLLGMIQEEGRSIIISSHILSDVEKVIDHAVIMQKGEILRDRSFDELREEYLRFRLTSLNGELPGELGFAGVLRCERNDRQAVLTVQHAGADELEVRAKELRCDIEFRPLSLEEIYELVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW1</accession>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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            <strain evidence="4">ST-NAGAB-D1</strain>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21582" checksum="342A6D4F634EA058" modified="2017-06-07" version="1">MQGPTEITFKDVTKTPELEDLINGKIAKLEKICPQMISCRVMVECPQKHPDTGNPHRVRIDVTVPPSQEIVAKQSASEGDMHTPLETVINNTFKAAEKQLKKLSEKEKGQVKIHPEQQVMGIVTKIFADEDYGFIRTVDTGDDVYFHKNSVLHDDYDRLNVGTGVRFVVHMGEKGPQASSVEIEYQPKPGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ0</accession>
    <name>A0A1U9NIZ0_9BACT</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
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        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="114"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="517" mass="55779" checksum="1A283A61C72EC5BD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ46</accession>
    <name>A0A1U9NJ46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67949">
        <property type="protein sequence ID" value="AQT67949"/>
        <property type="gene ID" value="STSP2_01101"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01101"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16201" checksum="563677E73E1B27A3" modified="2017-06-07" version="1">MKTFTDSSDRTWSINLNIDSAKRVRDLLGVNLLEPENGDPPLLTRLGTDEILLCDVIYCLCKPQADQLNVSDQQFGQSMGGETILAAQKAFYEELIDFFQKRGRRDRAKAVAAQAKVIETAIRTIEQRVDAIDIDKLIDGTISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ97</accession>
    <name>A0A1U9NJ97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67804">
        <property type="protein sequence ID" value="AQT67804"/>
        <property type="gene ID" value="STSP2_00954"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00954"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19497" checksum="8267553E9E7CECCA" modified="2017-06-07" version="1">MNFSAITIKPQDQSTRIATQSLDLGSRERIASACTSSLSITTSPATLRSGTILIFSNIVPLPSFVIATSAATWRSYEPEPVNRFSQTFLNIFVSIHAYRVFSPVCPFTTAMGPQGKIRRDVFRVGCPRSYSCSSRRRHIKLPAVKRPYSLRRDTKRFASPRTGSSKFIPPTFNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB5</accession>
    <name>A0A1U9NJB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68019">
        <property type="protein sequence ID" value="AQT68019"/>
        <property type="gene ID" value="STSP2_01173"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01173"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10436" checksum="730E2BF4D5A9F808" modified="2017-06-07" version="1">MPESQRLAKTFAYGGLAPWMVLAVSYCAGLRWRFLKELLDAFYVLGVLSYVLFYLVGVDAGWNLLNELIIFSLILSAILWFMRRHVFADKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE5</accession>
    <name>A0A1U9NJE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase 2, rSAM/selenodomain-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67945">
        <property type="protein sequence ID" value="AQT67945"/>
        <property type="gene ID" value="STSP2_01097"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01097"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21516" checksum="9CF8EBE5D4025D74" modified="2017-06-07" version="1">MDNITFAIPTYNNAETIMTVLKRCLQQDVKPKILIMDNGSTDGTVEMLRAAINNGIFGPVDIKLESVQRMLGGKSKNIPYVRYKLCQAVDTEYVFLLDADVLIPQHAILGLREMLEEDGDLVGAGIRVDPIVEHIQFGAILLKSEIARQIKWNNGEGKCECLWALQSINQLDDNYKVKRHPVYQAMHLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG4</accession>
    <name>A0A1U9NJG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolG_3</name>
        <name evidence="3" type="ORF">STSP2_01227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68072">
        <property type="protein sequence ID" value="AQT68072"/>
        <property type="gene ID" value="STSP2_01227"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01227"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="182"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48741" checksum="FA00C9DFC899502B" modified="2017-06-07" version="1">MTERNRFNRRQFLKTTAGVIGAFTIVPRHVLGGNGHVAPSEMLNHAIIGCGGISSAHLGYIAEDPRRKLVALCDVDSNRLAGKLAGVDKGVKGYEDFRDVLARPDVDVVHVATPPHWHGLMSVAAAEAGKDIWCEKPMTRTIYEGQKVVEAVQRNNRIFRINTWFRFKGGFAGGYHTYDGSGAEVRPTRKLVKSGLLGWPLKVTIGRASGLNWKQDVWVGKTGLVPQSVPDNLNYDMWLGPAPRKYYHPHRTHGSFRGYWDYDGGGLGDMGQHYLDPVQFILGKDNTSPQEVIVETQQQHTDAVLPWRRVTYKYADGCEVILDGDNRDENAAFIEGPGGKLYKNFKSDIPNIKQKVAEMPDLEPVVTDFTEAVLNRKKFALNEVNGHRSCTMVNMAKIAVRLGRNLKFDPDKQMFIGDDEANRMMRQPMRAPWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI1</accession>
    <name>A0A1U9NJI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane transcriptional regulator (Anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67898">
        <property type="protein sequence ID" value="AQT67898"/>
        <property type="gene ID" value="STSP2_01050"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01050"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27206" checksum="960CB64153A5C3F4" modified="2017-06-07" version="1">MSHLNKEQFEDIIAGKTKPDSHLENCPRCRSRLSDHVRIKDGLKAAFDNVEPPAELSRRLRMSFPDTVKHKFATAKTAGSALAVAASLLLVVILFANSMAPSTVQASPEDLSRIHDMNITGHDKFYSQSDPAKLSAYFRTELGFNPHLPRPDMGLELRGCCVSHFGESVKGSYVVDTPQGYISVVVVNDTPRDMVMHKIPSSGGQTVWCSKFAGNRMAAVQLGEYTYCAVGQADYEVLGELLDNLTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI9</accession>
    <name>A0A1U9NJI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01247"/>
    <dbReference type="EnsemblBacteria" id="AQT68092">
        <property type="protein sequence ID" value="AQT68092"/>
        <property type="gene ID" value="STSP2_01247"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01247"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="21600" checksum="7CCB18F9E70D7952" modified="2017-06-07" version="1">MSDVREESSQPDNYHRLLYQNQSRIYAYVLTMVGNYSDADDVMQETISFMWKRFEDFELGSDFVAWGIRIARYKILEHRRRQKKHDIVQYSDGSFEKLSSLAVNKNDNLSNQNVKLKECLKKLKHFKKRYFTVIALKFFENCNTNDIAKRIGVSVPNVYTIMSRAYGYLLACMKKSMSSAVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL7</accession>
    <name>A0A1U9NJL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caudovirus prohead protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01090"/>
    <dbReference type="EnsemblBacteria" id="AQT67938">
        <property type="protein sequence ID" value="AQT67938"/>
        <property type="gene ID" value="STSP2_01090"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01090"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006433">
        <property type="entry name" value="Prohead_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04586">
        <property type="entry name" value="Peptidase_S78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="640" mass="69412" checksum="79738D53F408F909" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM6</accession>
    <name>A0A1U9NJM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67780">
        <property type="protein sequence ID" value="AQT67780"/>
        <property type="gene ID" value="STSP2_00929"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00929"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012595028" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="37042" checksum="6416A0CBC63B59F7" modified="2017-06-07" version="1" precursor="true">MFTKFKTIKVSQQLSLALLLACALHVSSASASTSTDFAPAYGTGISTDAQTAIDRAVASWSTYLKDPVAVNLNFEFRTLAAGTITETSPGTLYGDYDQIRSMLVNNAGQPYNDREQSLLPNLPTASQFAATVPEGFSVQKSIAITQANYHALGGTGFTGSDGSIVFSNNVTWDFDRTDGITAGSYDFQGVAMHEIGHALGFTTELDYVDRVISDGLTRDTTWPTVMDLFRFNSAALDDPSFDFTTTQRNLTPGGSHAFYLGDDYLDLSTGEHTGDGQQGEHWKNNLSLGLMDPLAPGKMIDISNNDLAVMDLIGWDVEYSAVPEPATLILLSVGALALGRSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV4</accession>
    <name>A0A1U9NJV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68201">
        <property type="protein sequence ID" value="AQT68201"/>
        <property type="gene ID" value="STSP2_01356"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01356"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="252" mass="28647" checksum="B6E5B5F32B258DEB" modified="2017-06-07" version="1">MNWPLVSHFIGLLPWLILAGAFLVFKKNRDLRSLWLLVPVGVVLLGWNLLKALAHVQGSAGSYFDSLMQTALISYALWWLILRMISRFQSLTGFLLFLFTALIVTACNLSGDLFTFMQMGITTTFLGLIFWSSHAIARLICRKYPTRLKFALTLAVSLLVISLLLCVAYYTLLMSRFMGFRFDILLGTFMVSLVVSGILFGGILPFLLIAFFTDFYYTRFKEFLGVEDKTYVELAETQAPDKTEPAQKWVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX9</accession>
    <name>A0A1U9NJX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00966"/>
    <dbReference type="EnsemblBacteria" id="AQT67816">
        <property type="protein sequence ID" value="AQT67816"/>
        <property type="gene ID" value="STSP2_00966"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00966"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013138082" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="225" mass="23588" checksum="6C372BB187CA3BC9" modified="2017-06-07" version="1" precursor="true">MRKTLLAVLGICVLAGAANADFVTYTDSFDGYFNVDETLSVAQFDTSLGTLDSVQITATVGANGTINFENNTDNPVYRTISTYFTMGEETYTTNGDLGISLDGSSLADVAWEVLEDYQMDLTAYDGITDFAGTSGFSQEYMDESDSQTVAFGAGDDLSMFIGGGTVDFSLVGNANSALSMPGNGVSNVSTESSGCVTVVYGYTVPEPATVALLGLGGLALLRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK14</accession>
    <name>A0A1U9NK14_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">STSP2_01310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01310"/>
    <dbReference type="EnsemblBacteria" id="AQT68155">
        <property type="protein sequence ID" value="AQT68155"/>
        <property type="gene ID" value="STSP2_01310"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01310"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
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        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="8"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="399"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT68155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="607" mass="66653" checksum="4452DE1C372E551A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE9</accession>
    <name>A0A1U9NKE9_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Flagellum site-determining protein YlxH</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">ylxH</name>
        <name evidence="4" type="ORF">STSP2_01572</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01572"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="29874" checksum="280C888AFF100CE7" modified="2017-06-07" version="1">MTDENTKKLEEVMSEQSVRGKVLAVTSGKGGVGKTNIVANLSICLAVSGKKVVAMDADLGLGNLDVVMDISCKSNLGHVISGQKSLEEIIQVGPGGVDVICGGSGIEELANLNKFQRQRLLEELDGIQKNSDLIIIDNGAGISSSVVSFCLAADHTLVVTTPEPSAMTDAYAMIKVLAAHDYDGRISLVVNMARSVSEGKRVYRQISDVAMRFLDIPVYEAGVLCRTDKLVSAVRKRKPVVLAYPRSGITSSIGAMAARLSRGAAVKTKEGFFKRVANLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF1</accession>
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        <submittedName>
            <fullName evidence="3">NAD-reducing hydrogenase HoxS subunit delta</fullName>
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        </submittedName>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27620" checksum="8E0F1CC7DAC3B6EF" modified="2017-06-07" version="1">MDKPKVAIFDFACCEGCQLQIVNLEETILDLIGAVDVVEWREAMSEKSHEYDIAIIEGSITRPEDEKRLEIIRSRAKVLIAIGACATIGGINKLKNNFDLKDVKKCVYADSADKPHVDTEMTKALDEVVEVDYKIHGCPMNNEEFAYVVRCLLMGKKPVIPDYPVCVECKAKENVCRYEYGELCLGPIIRAGCGAKCPSAGYRCFGCRGYVDNPNVDAAKEIMDKYDLTVEDLKSRMVLFGSKQGPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF8</accession>
    <name>A0A1U9NKF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68423">
        <property type="protein sequence ID" value="AQT68423"/>
        <property type="gene ID" value="STSP2_01583"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01583"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775667" evidence="1">
        <location>
            <begin position="19"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="736" mass="83440" checksum="34CDC541F5415839" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH0</accession>
    <name>A0A1U9NKH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68432">
        <property type="protein sequence ID" value="AQT68432"/>
        <property type="gene ID" value="STSP2_01596"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01596"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35948" checksum="51E117A834C56D8A" modified="2017-06-07" version="1">MKRAIQASVICIVLVVVYLVFSANGLGLMPKSGDTHIEGDEKGVSSEGTRDMENNEVISVSNIDAGQGGAVAKLPNGVRFELIALCEHPSEGKKWWRPDGTLLGFAPHEKLNDSDRYNDVPFYEVVFRIEPDNGTTCKIDTSGRTAGFSGPHVIEGRAEGVVNGFEDAMYSLVPVAGGDDPVNLTFLLGDESGWEWHAKVKSPVHKRGVITSRATLDVSVGENRKVIAHVAHRIENEEVRVIARNNSGKVFYPGMSGKGRTWINIITAEFDHLTVDDAAAVELQVQEFQPVTFQNVSLQPGLKTDVEVVLEREEESGDAKRPAGPRKCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ0</accession>
    <name>A0A1U9NKQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01676"/>
    <dbReference type="EnsemblBacteria" id="AQT68511">
        <property type="protein sequence ID" value="AQT68511"/>
        <property type="gene ID" value="STSP2_01676"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01676"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30486" checksum="35A72E44C1C38E67" modified="2017-06-07" version="1">MHNKAKQDGGFTLIELLVVIAIIALLLSIMMPALGMVKQKAKMVLCKNNQRQLLIGANAYASANGNKFPPTVAATGRPNVINRPQDGKSAGEYLYTYIKDASVYNCPMTGFDADEKITMPSGDTYSYQELYENPEIAQQNSYEIECQYALLWNYEAFQREPVFIGPGPKSKNKLLICDTFMYTGALALGKNPQNQNKWACSHPFDTGTKDKTADVAFFIGSGDVDDINTDNALRKIKMNAGYTDGHVEVYEGSETVRQQVYGAWAKTFIPEKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW8</accession>
    <name>A0A1U9NKW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68447">
        <property type="protein sequence ID" value="AQT68447"/>
        <property type="gene ID" value="STSP2_01611"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01611"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364419" evidence="1">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="32022" checksum="2DC2D2B8C11EF21F" modified="2017-06-07" version="1" precursor="true">MNRFSPRILLVAFSFACLAQSVFAAGISIDAGLTPPEDRWILRNQFRYMEKEDDPTAMDREMYTYAFPTVIAYGFTPDLTLIARQAIKQRTMEMGETSRDAGFGDLLLLAKYKLYRLNTRDYIFGLAGTLGLELPTGDDDFGSETWDLQPGFFASWRSGPWQSDFNATYKWNGFADEGRNGLDPGDKISLDLAFAHQFNLTEEADTTIAPVLELNYEHNTRDSLSGRTVDNTGESLFFVSPGIKFTKSSFIFEALVQFPVWQDQEGSQLEQGTRFIVGTRFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL01</accession>
    <name>A0A1U9NL01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">STSP2_01779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01779"/>
    <dbReference type="EnsemblBacteria" id="AQT68611">
        <property type="protein sequence ID" value="AQT68611"/>
        <property type="gene ID" value="STSP2_01779"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01779"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="345"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="595" mass="66234" checksum="BD1C858CAB6C7E9A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL38</accession>
    <name>A0A1U9NL38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc/cadmium/mercury/lead-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01612"/>
    <dbReference type="EnsemblBacteria" id="AQT68448">
        <property type="protein sequence ID" value="AQT68448"/>
        <property type="gene ID" value="STSP2_01612"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01612"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012414393" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12279" checksum="B4BEF0A04088976E" modified="2017-06-07" version="1" precursor="true">MTRIFTILLTLTIIFTALGCTESEQVAPETTKLEESFAPNAQVYEVFGMDCPGCQGGVEKLLKKIPEVEDAKANWQKQRLVVTPKPGTEVTDEAVHDAIERANFTPGKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL66</accession>
    <name>A0A1U9NL66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">folD</name>
        <name evidence="11" type="ORF">STSP2_01818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01818"/>
    <dbReference type="EnsemblBacteria" id="AQT68649">
        <property type="protein sequence ID" value="AQT68649"/>
        <property type="gene ID" value="STSP2_01818"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01818"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="123"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="31510" checksum="227221091EA140A6" modified="2017-06-07" version="1">MTAQIIDGKQIASQMREEIKTKAAELTEKGVQPGLAVILVGEDPASQSYVRAKEKACENCGIYSSDNRLSADTTEEELLALIDNFNKDPKIHGILVQLPLPKHIDEGKVLLAIDPNKDVDGFHPVNVGKMVVGEKAFLPCTPHGIIQLLVRSGVQLEGAEVVVVGRSNIVGKPIANMLIQKSDTGNATVTVCHTRTKNMADHIKRADIVIAAAGGPNTVTADMVKEGAAIIDVGVNRVPDDTKKKGYRLVGDVDFECVKEKAGFITPVPGGVGPMTITMLLYNTVESAQRVADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI1</accession>
    <name>A0A1U9NLI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01941"/>
    <dbReference type="EnsemblBacteria" id="AQT68769">
        <property type="protein sequence ID" value="AQT68769"/>
        <property type="gene ID" value="STSP2_01941"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01941"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CBM-like" evidence="5">
        <location>
            <begin position="97"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38N" evidence="3">
        <location>
            <begin position="367"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38C" evidence="4">
        <location>
            <begin position="843"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136707" checksum="81DD9C3775E6A1AD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS4</accession>
    <name>A0A1U9NLS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrA</name>
        <name evidence="9" type="ORF">STSP2_02035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02035"/>
    <dbReference type="EnsemblBacteria" id="AQT68859">
        <property type="protein sequence ID" value="AQT68859"/>
        <property type="gene ID" value="STSP2_02035"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02035"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="286"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="720" mass="81232" checksum="125C5BDA9AC6C2E9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY5</accession>
    <name>A0A1U9NLY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gpr</name>
        <name evidence="3" type="ORF">STSP2_02096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68919">
        <property type="protein sequence ID" value="AQT68919"/>
        <property type="gene ID" value="STSP2_02096"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02096"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36652" checksum="6426F69DF690AFBF" modified="2017-06-07" version="1">MAYTPTEARYENMKYNRCGRSGLKLPAVSLGLWHNFGGVDTLENSREMIHRAFDLGITHFDLANNYGPPAGSAEETFGKVLAQDMAAYRDEMVISTKAGYYMWPGPYGEWGSRKYVLASLDQSLGRMGLDYVDIFYSHRPDPDTPLEETMGALATAVQQGKALYVGLSNYSAEQTKRSAAILKDLGTPCLIHQPRYSILDRWVEDGLLDVLEDEGIGGIAFCPLAQGLLTKKYLDGIPEDSRASKPWGFLKEETVTDELIGKMRELNDLAAGRGQSLAQLALAWVLKDRRMTSVLIGASRVEQIEENVKTLDNLELTDDELKKIDSILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM25</accession>
    <name>A0A1U9NM25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xerD_2</name>
        <name evidence="4" type="ORF">STSP2_01951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68778">
        <property type="protein sequence ID" value="AQT68778"/>
        <property type="gene ID" value="STSP2_01951"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01951"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="167"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="406" mass="47005" checksum="1D57C1DD9EAAFA5E" modified="2017-06-07" version="1">MQDAVRLWERPSRDGKSFTYYLIYIDDKGKRRQKSLGHANKRKAEQERTRLERHLRMGDRQALPMKLMELFEDYETRTQGQVKESSMLVAKNSMKTLVKAVGDIDYRSVRHEHGERLVQYCLDDGQTPATAAKKIRHLKRIFQLCVQRGQLDENPFRWVKTPKYSPQSINVLDSDAIIALLRAANSFVKCRTLDWDMLLRMALGTAMRRGELLNLTWSDIDTDAKTVTVAPKANTDSTWAWTPKDAERRTLPLTEELITLLGTAREESPDELPYVFISQERYATIQQKRTDGNWSQTDGTSPLNNFDRQWRRICKQADIEGTTFHDLRRTCLTNWLRSGLSELDVMNMAGHSSFETTRKFYLAVSDDLVDRTRRASEQALQQFSVANLLHTPVLRENEKSQSRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM42</accession>
    <name>A0A1U9NM42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbitol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gutB</name>
        <name evidence="4" type="ORF">STSP2_02179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02179"/>
    <dbReference type="EnsemblBacteria" id="AQT69001">
        <property type="protein sequence ID" value="AQT69001"/>
        <property type="gene ID" value="STSP2_02179"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02179"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="36718" checksum="54A39B69805063B9" modified="2017-06-07" version="1">MKSFKLTGIRQMEVFDVPEPTAKDDQVVVELAAIGVCGSDVHYYVNGNIGSQVVEYPFAVGHECAGTVVKTGGSVSSLKEGDRVAVDPAMPCWKCDQCKAGRHHTCRNLKFLGCPGQAEGCLSEYIAMPETSCVKLPEGMSFTRGALSEPLAIGVYAVRLSIPMQDAKVAILGVGPIGLSVLLAAKAGGAETVFATDKLDYRLKAAKQAGADAAGNPDKQNIVKQAAVVEPGGFDVVFECCGQQDALDQAIEILKPGGKLMVVGIPQEDRVSFCPDKTRRKEICIQNVRRQVDCVDATLEMMADGRLNADFMATHRFGFDAAQEAFDLVSNYQDGVIKAMIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM61</accession>
    <name>A0A1U9NM61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23648" checksum="D51BEDF0BB881B76" modified="2017-06-07" version="1" precursor="true">MKRLVFCVTLALLILGMNTSAGAALTGVSDPSFESDTWDDGWFERGPYTGLQSDTDPAYPETPYGEMWMQFGNQSWMFQQIGTWEADMSLDIRMLSGKVAGKSYGGLKISLFAGGDASLASDAGDNDVPPDNLVNVVGATMIAESQQFDYPNGDDMGTFEVNVSLNTGSTGTEGDPLWLLVQSQGRQKVLVDNVAVTPEPATISLLAAGLFGITRRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM82</accession>
    <name>A0A1U9NM82_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="21"/>
        </location>
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            <end position="178"/>
        </location>
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        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19625" checksum="E35B7A8816C83DBA" modified="2017-06-07" version="1" precursor="true">MSTKVKTAVFSILLSILPSLAGCTGSEIVGAYMALVIAKPLLDSYEPSSSSSSASTSDTKQYSRPIRRSTAKRTAKVPTVTKRSAPNKNDYRTEEIIAAYKNLNWEKCLRLAASQIHSAKMSHSDKCTSKILAGAIHYQMGDTDAARMYFDSSCRFEDCRIHELLSPSVKKFYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM89</accession>
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        <submittedName>
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        <name evidence="5" type="ORF">STSP2_02247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="STSP2_02247"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="10"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="570"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69062.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="570" mass="63637" checksum="4417B84C10E31E2D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF0</accession>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT68686">
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        <property type="gene ID" value="STSP2_01856"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="144"/>
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        </location>
    </feature>
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        <location>
            <position position="59"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68686.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="409" mass="46022" checksum="A5D1B11F8887F3FF" modified="2017-06-07" version="1">MDEGSKKRILFVDDDKHLLNGLRRMLRKMKDRWDMDFANGGQEALDALRLNKYDVIVSDMLMPGISGVRLLEHVRERYPGTIRFMLTGCSKEPLNEHAIMCAHQMVAKPCDTDELINMIEHSLSLHDGIKSHKAAQVMAQMRSIPSMPRIYQRVIKTLRKPHCSLRRVGRIIAEDIGMSSKMLQVANSAFYGKSGHIADPTRAVVHLGLRTVEALVLTHGVFSTLTEEQMKDFWVDGIHEHCVRVGLLTKKICKLEGMSEEELELASMAGILHDAGLMILVSEFPEEYRRAIELSRSEHISIYESECEEIKMTHAELGGCLLDLWGLPNAIIEAAAMHHDPGLSEGRGFSILAAVYAADVIDHELCSSPGGGWVKGADMEYIEKMGLSEKLQQWRKLHLPTGDRELEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT7</accession>
    <name>A0A1U9NMT7_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Sporulation kinase D</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kinD_2</name>
        <name evidence="3" type="ORF">STSP2_02332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02332"/>
    <dbReference type="EnsemblBacteria" id="AQT69145">
        <property type="protein sequence ID" value="AQT69145"/>
        <property type="gene ID" value="STSP2_02332"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02332"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27769" checksum="DEB2F3D463B230C5" modified="2017-06-07" version="1">MAGILEKRQAIHSRLATEQERNAELQSHVDSLQPLANVGLVSSMIAHEINNILTPLGSYAELSLQHPDDPNLTEKALKKTLANTKRASQILDSMLKLASNKPQPKEICNVNALLDEVFQCIARDLGKDGISVERDIPEELAVSVQPNLFQQVLMNLILNARQAMLPAGGRLRILAAIKTDCVEISVFDTGEGIAASDLGHVFEPFFTKRGSEKSDKKGSGLGLAFCKKIVEAHGGTISVDSERHVGTTFKITLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX1</accession>
    <name>A0A1U9NMX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stalked cell differentiation-controlling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pleD_3</name>
        <name evidence="3" type="ORF">STSP2_02334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02334"/>
    <dbReference type="EnsemblBacteria" id="AQT69147">
        <property type="protein sequence ID" value="AQT69147"/>
        <property type="gene ID" value="STSP2_02334"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02334"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17733" checksum="254950EA86C71309" modified="2017-06-07" version="1">MVEENKNQDIQPKVLVVDDNAQNLELLLAYLEEIDCETISAMGGKEAIEKTRTEKPDLLLLDVMMPHISGFEVCKRLKSDPNTAEVPIIMVTALSELGDIERAIDCGTDDFLSKPVNKLELLTRVKTMLRLKNLSDKLEKTLEYLSQVELQMGKGDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN16</accession>
    <name>A0A1U9NN16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cofactor-independent phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02488"/>
    <dbReference type="EnsemblBacteria" id="AQT69299">
        <property type="protein sequence ID" value="AQT69299"/>
        <property type="gene ID" value="STSP2_02488"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02488"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02535">
        <property type="entry name" value="hyp_Hser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="4"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="398" mass="44029" checksum="11D49A212CC0813C" modified="2017-06-07" version="1">MKTKYAIIIPDGAADYPIEEFDGKTPLQAAQTPNMDRIAIQGRQGTVQTIPAGMPAGSDVAQMSLLGYDPLKYYNGRAPIEAAAQDIKLGEDDWAFRCNLVTIADDVMADHSAGHISTDEAAKVIADIKTLFAEDARLKFYTGVSYRHLCIITGEDFEKIVTTPPHDIIGEKASKYYPKGKHAKMLVEAMKRSQDFLADHDINRVRKDLGENPVTSIWLWGHGQRMALDSFKKRFKLSGAAITGVDLIRGLAKLIGFDILHVEGATGYIDTNYYGKGQAAVEALENYDLLFVHVEAPDEAGHSGNAQAKKYSIEQIDRHIVGPVHEALEKYQDYRIIVLPDHPTPIEIQSHTDEPVPFAMAGTNVKASLKKPFSEENAFETGLHIPRGSELMEYFLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN31</accession>
    <name>A0A1U9NN31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69321">
        <property type="protein sequence ID" value="AQT69321"/>
        <property type="gene ID" value="STSP2_02510"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02510"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011962311" evidence="2">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="493" mass="56016" checksum="42D29E929E93B5E0" modified="2017-06-07" version="1" precursor="true">MMKRRDFIKYCNSAVFALPLMSLPCLAEEESFEKPTNFLLLTADDLNYDSVGCFGCEIPDITPNIDRLGADGVKFTNAHVNIAVCQPCRQSIMTGRYPHTNGAKGFEPINEDLPTLGEILSKAGYINGVLGKERHMRPKHKYAWDYYITEAELASGAGIGRSPEKYYNYAKKFFESSKKQGKPFFLNANSHDPHRPFAGSKQEERAWGHDLPKVTRWIKPEEVTVPGFLPDLPDVRKEIAQYFTSVHRCDQSIGAVLKALEETGLAENTLVMFLSDNGISAPFAKSNCYLTSTKTPWIVRWPGKVKPGTIDSQHMISGIDYMPTILEAAGIKDVTDMDGSSFMPLLHGVKQPERKYVFTEYHKTFAGRRYDMRAIQSKRFGYIFNPWAKRTGPMRMDSTSGLTFKAMKRAAKSNSKIADRVELFENRVLEEFYDFKNDPDGRNNLIEDISYQAEIRAMRELLEKRMKKTNDPALHAFQNRDNPKAIEKFMKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN65</accession>
    <name>A0A1U9NN65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69184">
        <property type="protein sequence ID" value="AQT69184"/>
        <property type="gene ID" value="STSP2_02371"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02371"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="39114" checksum="3E6F7BB619CEAA49" modified="2017-06-07" version="1">MTSRERVLSVFEHELPDRVPCWCGSSVEFWEKAKKELGLDDEGLRLRFKDDFRRVFADYAGPEFPLDDPKAICRTPFGIEREGYGYGQPLSHPLAEATLEDVENYPWPDPAWMDVSKIKSTAQAYDGRFAILGGDWSPFWHDAIDLVGMENLYIKMYSEPEVVDAILKHIVDYYFEVSKRTFDAAADAIDIFFMGNDFGSQTGPLMSPEMFDRFMVPHLARLCDLGHSYGLKTQLHCCGGVYELIPSMIEAGLDGLHAVQTSCRGMDMRKLKFEFGSKIVFNGAIDSHHTLIEKDTQGVVEDTRKVLDTMMPGSGYVAGASHDTILEETPVANVLAMFDAVLRCGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN95</accession>
    <name>A0A1U9NN95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stage 0 sporulation protein KD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppD</name>
        <name evidence="6" type="ORF">STSP2_02562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02562"/>
    <dbReference type="EnsemblBacteria" id="AQT69373">
        <property type="protein sequence ID" value="AQT69373"/>
        <property type="gene ID" value="STSP2_02562"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02562"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="38793" checksum="0E8498704B35F551" modified="2017-06-07" version="1">MAENNLLSIQNLTTHFFTEDGVAKAVQDVSFDIPHGKTVAVVGESGCGKSVTSLSVLRLVPNPPGKIMNGEIYFRGENLFHKTEKQMRRIRGNDIAIIFQEPMTSLNPVYTVGNQIIEVIRLHQGIKGAKAWEAATKMLRQVGIADPEKRVREYPHQLSGGMRQRVMIAMALSCNPALLIADEPTTALDVTIQAQILELLRELQAQHNMSIMLITHDLGVVAENSDHVVVMYASRVAEKADAEPLFHDPLHPYTKGLLTSLPRLGEEKERLDVIGGSVPNPLNFPSGCKFHPRCSIGNDDPRCRSEEPELREVEPGRCVACWYARGYETEQEFKEYEAKYGKHKQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB4</accession>
    <name>A0A1U9NNB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">STSP2_02582</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02582"/>
    <dbReference type="EnsemblBacteria" id="AQT69393">
        <property type="protein sequence ID" value="AQT69393"/>
        <property type="gene ID" value="STSP2_02582"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02582"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29869" checksum="F3B98EF1304D6B7D" modified="2017-06-07" version="1">MSSGLQNILASTSLLDHVASKDLFTIGAFRFTNHMLMMTLAVIGLCIVMPLAIGRRKLVRKGFGNAIEAICLYLREEVARPFLGEKTDKYIGFIWTMFFFILTMNLFGLIPMDRIIFFITDKQNHYGGTATGNIWITGALASISFVTFHWAGIRENGLAHYFKSFIPKVPWPLIPLMYLMETISSFVRVFALAIRLYANMLAGHILLGVLIFLIILFKNYLTAFPAVPAYIAFSILELFVAFLQAYIFTFLTTIFIGFAVFPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ4</accession>
    <name>A0A1U9NNJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69473">
        <property type="protein sequence ID" value="AQT69473"/>
        <property type="gene ID" value="STSP2_02664"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02664"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="576" mass="67369" checksum="084A8A4AA91514DE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ5</accession>
    <name>A0A1U9NNJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppiA</name>
        <name evidence="4" type="ORF">STSP2_02594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02594"/>
    <dbReference type="EnsemblBacteria" id="AQT69405">
        <property type="protein sequence ID" value="AQT69405"/>
        <property type="gene ID" value="STSP2_02594"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02594"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011812465" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="107"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29294" checksum="4F01D6A8CC24DED9" modified="2017-06-07" version="1" precursor="true">MKSLKYLLTFALVAGVISFGIAGCGGDEEATEIEQPETEQVQPDEPTEPEAERARQEPTEEIETEPAEEESAAEPEQEPDQEDSDQPEEEQAAQDEPLKVRLATTKGEIVIELYQEDAPITVANFMSYVLDGDYDGTIFHRVIPGFMIQGGGLTPTMERAPMNASIKNEAGSNLANQRGTVAMARKTDPDSATNQFFINLTDNPHLNYGGPGQPGYAVFGKVVEGMDVVQEIAQVQTETVGEFQNVPADPVIIEKAEVATDTQVDAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP3</accession>
    <name>A0A1U9NNP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan endo-1,3-beta-glucosidase A1</fullName>
            <ecNumber evidence="2">3.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glcA_3</name>
        <name evidence="2" type="ORF">STSP2_02323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.39" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02323"/>
    <dbReference type="EnsemblBacteria" id="AQT69136">
        <property type="protein sequence ID" value="AQT69136"/>
        <property type="gene ID" value="STSP2_02323"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02323"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="247"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="503" mass="55704" checksum="742130A0AC48CF1B" modified="2017-06-07" version="1">MSMHRWVIYSNIIFGDGHMRLFLLLLFCLSNLSFANLLSNPGFEDGGTGQLTYTTIPGWSVWGTNGWHHNDPGRTIEQKAVKLWWDDAGLFQDFSVTGGKDYRFSASMLSGSSEPLTGWEGIVKAEFYDGVNMQPSDAVSVTEIGRFYPGDDAVDQWKKVSSTVTAPAEAEVGRIVFMITGTSGSGALNFDSASVGAALPSADFNGDGLTDMRDLARLGDSWMQANSACDLDGSGLIDIDDLLVFASEWLTDTTIYAGYDLVWADEFDGNTLDEANWTRMTISGADSGNWELQHYTDEAANACVADGELVIKAMEQSYWSASENRMYDYTSARLTSTGKRDFLYGIFEARIKIPTGQGIWPAFWMLPSDWEYGGWPASGEIDIMEAINDTDVIHGTIHYGGQGAHDSSGGSYSDGGVNFGDDYHIYTMVWEPTVMHWYVDGQLYSTKSSWWSEGEPFPAPFDKRFHLLLNIAVGGNWPGSPDETTVFPQTMHVDYVRVYQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR1</accession>
    <name>A0A1U9NNR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="5">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nasD</name>
        <name evidence="5" type="ORF">STSP2_02666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02666"/>
    <dbReference type="EnsemblBacteria" id="AQT69475">
        <property type="protein sequence ID" value="AQT69475"/>
        <property type="gene ID" value="STSP2_02666"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02666"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23620" checksum="DECF9C7CBF6F8ACF" modified="2017-06-07" version="1">MLQDGEKGAIIQRDKKTYAVAPHIPCGVVKPETLRKIADVAEKYGAQALKVTSAARIAIVGLDEKDVDAVWSELGMSPGFAVGICVRSVKACPGTTFCKKGMQDSLALGMKFDGKYHGMDLPGKFKIGVSGCPNQCAETCIKDVGLVGMKNGWKVLVGGNGGGRPRLARELAKDLSETEAMELVDRIIDYFKANARPHQRIGAMLDKMDFEEFAAAVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS1</accession>
    <name>A0A1U9NNS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02676"/>
    <dbReference type="EnsemblBacteria" id="AQT69485">
        <property type="protein sequence ID" value="AQT69485"/>
        <property type="gene ID" value="STSP2_02676"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02676"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="682" mass="76380" checksum="13A1E4E8CBCD4A69" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU3</accession>
    <name>A0A1U9NNU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Regulator of sigma E protease</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rseP</name>
        <name evidence="11" type="ORF">STSP2_02816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02816"/>
    <dbReference type="EnsemblBacteria" id="AQT69622">
        <property type="protein sequence ID" value="AQT69622"/>
        <property type="gene ID" value="STSP2_02816"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02816"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="728" mass="79585" checksum="7ACF1189B649AAEF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP24</accession>
    <name>A0A1U9NP24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-fucose isomerase</fullName>
            <ecNumber evidence="7">5.3.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fucI</name>
        <name evidence="7" type="ORF">STSP2_02455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02455"/>
    <dbReference type="EnsemblBacteria" id="AQT69266">
        <property type="protein sequence ID" value="AQT69266"/>
        <property type="gene ID" value="STSP2_02455"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02455"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="6">
        <location>
            <begin position="192"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="569" mass="62241" checksum="63E517DC2762616C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP26</accession>
    <name>A0A1U9NP26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine gamma-lyase</fullName>
            <ecNumber evidence="5">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdeA</name>
        <name evidence="5" type="ORF">STSP2_02788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02788"/>
    <dbReference type="EnsemblBacteria" id="AQT69595">
        <property type="protein sequence ID" value="AQT69595"/>
        <property type="gene ID" value="STSP2_02788"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02788"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="430" mass="46383" checksum="91CA42FEFDF46CC1" modified="2017-06-07" version="1">MSDTTNYKLETLALHAGHDIDADTLSRAVPIYQTSSYVFKDSKHAADLFSLAEPGNIYTRIMNPTTDVLEKRVAAMEGGVGACAFGSGMAAITAAVLNICRSGQHVVSASTLYGGTYTLFSQSLPKLGIETTFVDPSVPDNFAKEIKDNTRLLYVETIGNPRNNISDFEEIAKIAHENNIPLIVDNTVASPILFRPFEYGADIVVHSCTKLIGGHGTSIGGVVVDSGKFDWGNGKFPELSEPVPSYHGLKYTEAAGPAAYITKIRTQGLRDMGASMSPFNAFLFIQGLETIHLRVPRHCENALALAKYLEKHPAVSWVNYPGLESHPDHVLAKRYLPNGQGAILGFGIKGGKEAGEKFINSVKLSSHLANILDSKTLVIHPSSTTHQQLSEEEQASAGVTPDFIRVSVGTEHIDDIIADFDQALEASQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP62</accession>
    <name>A0A1U9NP62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ORF">STSP2_02699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02699"/>
    <dbReference type="EnsemblBacteria" id="AQT69508">
        <property type="protein sequence ID" value="AQT69508"/>
        <property type="gene ID" value="STSP2_02699"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02699"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="15"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="556"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="868" mass="96942" checksum="DB17EEBF97DB28D7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF7</accession>
    <name>A0A1U9NPF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase EpsJ</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">epsJ_2</name>
        <name evidence="3" type="ORF">STSP2_02818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69624">
        <property type="protein sequence ID" value="AQT69624"/>
        <property type="gene ID" value="STSP2_02818"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02818"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="37826" checksum="CE43A719CA236E56" modified="2017-06-07" version="1">MPDQYDKTTISIVIAAYNAAEHLPRAVKSVLAQTIQPNEIIVVDDGSTDNTKQVLEQFGDRIKYIYQNNAGPGAARNTGIQTATSEWISFLDADDEYLPNKLETQLEILARHPDLHWITGNYIRCLCDTQTRVPLRTKDEINQILNGSDTYDDFMQAFTIGVFGWTGTMLIRRNAILKAGMFPTDIYLAEDIDLWLKIAYNHPRIGFAYEPLAIYHMGVQGSLARNKASYADTNNFLSHHLKLAKQHNCEDAFQPCARRILVAWIRSALFDDRVKNVRSAINDFRNLLPPGLYLFFYVLSIFPQLTMKTCLLLSAISRKLRLRKRVWHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG7</accession>
    <name>A0A1U9NPG7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69811">
        <property type="protein sequence ID" value="AQT69811"/>
        <property type="gene ID" value="STSP2_03008"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03008"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956678" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="26923" checksum="DF26C2D322B7AD5C" modified="2017-06-07" version="1" precursor="true">MKKFIVLTCVMALAAVSSAATVWNPAGNGITPPDTGLWGDAANWTGGLPGDTEAKAVFNVPGAAEAQVAGSYSGFQVVQGDNNPGGVLRVLNGGTITTVSDNWSAVGYNDTAQLIVEAGGTFNFGQHAWIGLNDGAVGTVDIFGTVTVGSMLGLGWGGSTSQGFVNVYDGGLLALANIHGDGSSSIKHGSLLNINGTGKVTLLNDRIGTINDYAANGLIAGDGIIGNVEATYDEATNLTTVTVVPEPATLSLLGLGALAMLKRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP1</accession>
    <name>A0A1U9NPP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Curli production assembly/transport component CsgG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03102"/>
    <dbReference type="EnsemblBacteria" id="AQT69902">
        <property type="protein sequence ID" value="AQT69902"/>
        <property type="gene ID" value="STSP2_03102"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03102"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005534">
        <property type="entry name" value="Curli_assmbl/transp-comp_CsgG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03783">
        <property type="entry name" value="CsgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23018" checksum="E95BA308521A9694" modified="2017-06-07" version="1">MRSITIILLSLVIIASAGCSSGEGYSRQGYDFSTVDTVAVISVEGRIAGAAAKNQISDYFIAELLQKGYAPVERAEVEKLLEEHEFQASGLTSNTNAAQAGRILNVPAVIIVNIPEFKDNIAISAKMVDVEDGSILWLATGEGKVGEFLTTLGGAAAGAAAGIAVSGEDDEAVGGIAGGVLGGVVANQMTPQKEKKAKEIIDKMCESLPSLMTKPEKKGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV5</accession>
    <name>A0A1U9NPV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69963">
        <property type="protein sequence ID" value="AQT69963"/>
        <property type="gene ID" value="STSP2_03163"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03163"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="12009" checksum="5013AF932D0B10DC" modified="2017-06-07" version="1">MTQEELEQQTQSLRDRLDAATDPVEINILNKLIPVNEDPNVYGFYTDVEIDGLLRLRNDYLNEQGQALFDELLENPTIYQPEDIITEIIAEVRYRLTGARIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ01</accession>
    <name>A0A1U9NQ01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">ispG</name>
        <name evidence="5" type="ORF">STSP2_03212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03212"/>
    <dbReference type="EnsemblBacteria" id="AQT70011">
        <property type="protein sequence ID" value="AQT70011"/>
        <property type="gene ID" value="STSP2_03212"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03212"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38220" checksum="9BF30C9492400A8C" modified="2017-06-07" version="1">MVKTSYNRVMIKRRNSKTANVGSIKLGGSNPIVLQSMTKVATTDVAACLGQIAELREAGCGLVRLAVPTKADTAAFAKIVNQCDMPLVADIHFSRARAIEAIEAGAAKIRLNPGNLKERADILEIIEAAKAHGTAIRVGVNEASIRDLRAGDVAEGGRVGLMLEEMSGYVRVFEEAGFENIVLSAKSADTVRTIEINRLMAEKFEYPIHLGLTHAGLVEDATVSSSVAIGTLLAEGIGDTIRVSVAGDPLEEIRLGREILASLGLAEKRGPELIVCPTCGRCQIDVVALARKVRGALENTDKKAKVAVMGCIVNGPGEAADADVAVCAAKGKGFLYSHGKKLCTVPEDQLLDSLVQEIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ04</accession>
    <name>A0A1U9NQ04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">STSP2_02789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02789"/>
    <dbReference type="EnsemblBacteria" id="AQT69596">
        <property type="protein sequence ID" value="AQT69596"/>
        <property type="gene ID" value="STSP2_02789"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02789"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="33727" checksum="EEFE002F4C5ABA84" modified="2017-06-07" version="1">MSNLVEKIEKLKKERNAVILAHNYQIGEVQDIADYTGDSLGLSVQAAQTKADVIVFCGVLFMAETAYILSPDKTVLLPEKNAGCPMADMITAADLQKLKDQHPDALVVTYVNSPAEVKALSDYCCTSGNAVELVSTLPKDRKIIFCPDQHLGSYVMQQTGREMILWPGYCPTHVRITSEDVEAAKNQHPGAVVLTHPECSSDVKRASDELLSTGQMIKYAENSDVKKFIIVTEQGILHTLRKKMPNKEFIGVSDKMICPNMKKIDLAKVAWSLEDMKHQITVPDEIRIKAKGSLDRMLEVLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ30</accession>
    <name>A0A1U9NQ30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pathogenicity island 2 chaperone protein SscA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69720">
        <property type="protein sequence ID" value="AQT69720"/>
        <property type="gene ID" value="STSP2_02916"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02916"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013138078" evidence="2">
        <location>
            <begin position="31"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="37404" checksum="1EA92820FF3900CB" modified="2017-06-07" version="1" precursor="true">MTVSSMASRVFTFFVLLTAAAMIGCAPQEAKPSDIGGVSPDAIELYVDAAMLKDLNERERALQRVNEALELSPDFAMAYSLKGDLHQAAKQFGKSADAYERATEIDPWSFKDFFNLGKVTAVLEQWSRAVRAYVRATKLEPKHYGAHIGAAKSYYHLDDYAQAMKYTNQAAGIDPNAPGAAVLAGDILKAQDQRADAIESYRRALELDSDNPKVMISLAAAYLQDTRYDAAKELLESAIDIDPQNATAHQYLGFINLKQGNIQRSLQNYTMAVDLDQNDWMAHKGLGVVYVLQGVKKKDAELKQEGLDHWRTSLQIKPDQPQLQRMLDKYSSNMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ64</accession>
    <name>A0A1U9NQ64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminopeptidase YsdC</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ysdC_1</name>
        <name evidence="9" type="ORF">STSP2_02850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02850"/>
    <dbReference type="EnsemblBacteria" id="AQT69656">
        <property type="protein sequence ID" value="AQT69656"/>
        <property type="gene ID" value="STSP2_02850"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02850"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38861" checksum="A2934DD960CC7B66" modified="2017-06-07" version="1">MNKTSEKFLQQLLEAPSPSGFEQPAAKVFRDYVKKDVDQLITDAHGNTITVLNPKAKFKFMLAGHIDEIGLMVTHIDKDGYIYTAQVGGMDPALLIGQRVKILTEKGNVFGVIGRKAIHHMTPDERGKGVKMDNIWVDIGADSKEDAQKRVEIGDPMVIDVPYRRMTDDKIVSRAMDDKAGAFIVAEVMRRLAKKKKDLKISVIGVATVQEELGLRGAITSSYSVNPDAGIAIDVGFASDHPDTDKKKLGDLKLGEGPNLHRGANINPVLEKALLKTAKKHKIPYQITAEARATGTDANAIQLCRGGAAATLISIPNRYMHTPVEMISISDMDNIIKLIVAYITEHPANRDYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ69</accession>
    <name>A0A1U9NQ69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69760">
        <property type="protein sequence ID" value="AQT69760"/>
        <property type="gene ID" value="STSP2_02957"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02957"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="28928" checksum="391FF297FD992E7C" modified="2017-06-07" version="1">MHNKKAFTLIELLVVISIIALLLAIMMPALGKVKTMAKRVYCANNIRSHSLYLKLYATDNDGRYHSHGDHSPEYARSNGSNDSLYHAMVPYIDDLDVMLCPVIRSIRSGDSIFKNPEYLHENGAYGGWGSVDLDAGQDPANITSPYMWLANYTYFGEEPKYSFRDDEGNMVNNPVHWPKNDGEATSRTPIFAHRVSNAAGGSGHFWDLSHGGNLVEMDTKFNVFSTATDNPLGYGDGSVTYNKKSEMEPRANAGAAGIIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ83</accession>
    <name>A0A1U9NQ83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03295"/>
    <dbReference type="EnsemblBacteria" id="AQT70093">
        <property type="protein sequence ID" value="AQT70093"/>
        <property type="gene ID" value="STSP2_03295"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03295"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021341">
        <property type="entry name" value="DUF2958"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11171">
        <property type="entry name" value="DUF2958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12222" checksum="07D4170A7236AD30" modified="2017-06-07" version="1">MRLLTDEIAAKIPPLYHFEQTGTETVAVVKFFDPVGRWTWYVAEGERQPDGDWLFFGAVDGFDFEYGYFRLSDLQHAKDGLTGMMALPIERDLYFTPIPLKELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ89</accession>
    <name>A0A1U9NQ89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase YycG</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yycG_3</name>
        <name evidence="7" type="ORF">STSP2_03304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03304"/>
    <dbReference type="EnsemblBacteria" id="AQT70101">
        <property type="protein sequence ID" value="AQT70101"/>
        <property type="gene ID" value="STSP2_03304"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03304"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="277"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="536" mass="60295" checksum="71D59B4AB0C79369" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ97</accession>
    <name>A0A1U9NQ97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70112">
        <property type="protein sequence ID" value="AQT70112"/>
        <property type="gene ID" value="STSP2_03316"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03316"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31009" checksum="8BBBF6558F452B2A" modified="2017-06-07" version="1" precursor="true">MSTLTKVLIVLLSFGVIFLCATTVSYVSSTSTAQSDLEDLRTEYKALEGDRLAAETELNQVQAQAKKLEEELQAEITELRKENNMLAVDKRTAETASMEYQSKYTNLASSLESLENTIGNLQTLLASTQDQLEDTRAQSIRDRKYLNETTEELMAKTVRLESLQARLKQVLEQKQTLEEQLAGEEVTVATVTPTPGEIAKPAGQVTTTQPIRGLVTEVRENLVGISVGAADGVKEGQTFHVIRGEEFICNIEVTNVDTSKAAGVLELVEQRPRVGDNVTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC4</accession>
    <name>A0A1U9NQC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gliding-associated putative ABC transporter substrate-binding component GldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02901"/>
    <dbReference type="EnsemblBacteria" id="AQT69706">
        <property type="protein sequence ID" value="AQT69706"/>
        <property type="gene ID" value="STSP2_02901"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02901"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="3">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="661" mass="74469" checksum="7FC7C192183FAC42" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH4</accession>
    <name>A0A1U9NQH4_9BACT</name>
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        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsB</name>
        <name evidence="8" type="ORF">STSP2_03387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03387"/>
    <dbReference type="EnsemblBacteria" id="AQT70182">
        <property type="protein sequence ID" value="AQT70182"/>
        <property type="gene ID" value="STSP2_03387"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03387"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
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        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="317" mass="34584" checksum="DC17C317B2B2EFCB" modified="2017-06-07" version="1">MNKELARDLISAGVHFGHGVSRWNPKMKPFIYGKRSKIHIIDVKETLKGLILGKRLLVDVVSSGKDVVFVGTKRQAKQIVAEVAEDCGMHYVDERWLGGMLTNFKTIRSRLKRLDELETLEKTGEIASESKKQASRLKRELRKIRTNLGGVREMNRMPGAMVVVDAKKEHLALREAEKLGIATIGIIDTDSDPDAVDVAIPANDDSIKAIEILIRELGEAVKLGKTVVKPKDTDEARGKSKRRALASATAEQEQPAEAGTATAEPAAKPAEKPAEQPAEAPEAKPAPAVEPAEAQEPAKTEEAPKEEEKGAEEKQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI1</accession>
    <name>A0A1U9NQI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xcpQ</name>
        <name evidence="5" type="ORF">STSP2_02963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT69766">
        <property type="protein sequence ID" value="AQT69766"/>
        <property type="gene ID" value="STSP2_02963"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02963"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798491" evidence="4">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48587" checksum="DF7A33DB3F7BC65E" modified="2017-06-07" version="1" precursor="true">MVNIRFMIIFVMLLCSSVVWAETAESEDAGNAEVIEDVKPAEGIKVGKADPFEIVVPPEEPEPEVEVEIDEEPVAVGRKMVMEPVKERPAMFIESMMLKYLDAEKVLPAVGSLLTEWGSAAVDENTNTLIICDSRENLDNILAQIRKADQTPQQVLIEVVILDVLLSDDTEIGVNWEDLFKEAGSPHSVNYTQTLNTLSEGGSFNLIQNSVSTTVNLLQQERNVEILASPRVLVVSGHPAHIQTVEEIPYTELTQSTGGVGSQEAITSTRFKDAGITLEVIPRVTDDGEIMLDVYPQQSVNTGTAGVNSNVPIVNKREAKTTLLMKDGQVLALGGLRRKDTKLTQDKIPLLGDLPLLGWLFSSDKTVVTNSELVVLISPHIYKPEDKPSDYQMKRFEEIRNRETLRLPENGRLKTEPIEPRPEFEYLRDTLTFPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI6</accession>
    <name>A0A1U9NQI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70191">
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        <property type="gene ID" value="STSP2_03396"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="31618" checksum="1720D7E620551146" modified="2017-06-07" version="1">MGQSKLSRIDVFVTVITLIIISFMMTSFLGCVVVYSPKLKCYNNLKGVGTALAAYAYYNNDEFPVAGGDGPWSQKLGWDYDDPKASFDPGDKYEHAPRTLTASWYILTREMDLDPSALVCPAVIGATRFNGDGSSTELIDMWDFGDTPYEHVSYSIQNQYGKYPAHKTSPADNAIAADMSPWFDANGDILPPATGTDSPQLIDPSDLDTWQLGNSRNHNGKGQNVLFNDMHVSFEKTPTVGVDQDNIYTYWTNPDNPTPADKQQGQNPTARDKANDSQAPEDSFLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL7</accession>
    <name>A0A1U9NQL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_03319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70115">
        <property type="protein sequence ID" value="AQT70115"/>
        <property type="gene ID" value="STSP2_03319"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03319"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18286" checksum="1264B74B4886D4B4" modified="2017-06-07" version="1">MKWIVFIILLITFALLDAGNALNYIALGGTNIRPAMLLILMLFFAINCERHTAILVSFAAGFMADAAGLTVGPHIVAFGIIGYVASTLQRDMVMQSYVRQCFTILIIGAFALAGVRGLMMLKPDLQTASNLTALIGTIIYSAIAGPLVWTVLTWLSPLVGIDRLRSNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL9</accession>
    <name>A0A1U9NQL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03003"/>
    <dbReference type="EnsemblBacteria" id="AQT69806">
        <property type="protein sequence ID" value="AQT69806"/>
        <property type="gene ID" value="STSP2_03003"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03003"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="345" mass="38128" checksum="7734BC133B99A805" modified="2017-06-07" version="1">MKSLSDKHSNMTTFASLNSEEYIRCLGPNAKNEDFAPLASTSDAKFHTGIGGVNYICQTGDGKVEFIFFDSHVLAYVNSALGYPAYYPIQPVEIKKPTRAVLMDLDGTSVRSEGFWIWIIQMTTASLLDKPEFELSDEDLPFVSGHSVSEHLQYCIDKYCPDKTIEQARDYYFEHTHREMNEIMNGRGRTDAFVPTPGLKNFLCELKSRKIKIGLVTSGLYEKAWPEIVSAFKTLNMPDPKEFYDAIITAGFPLRKGSVGTLGELSPKPHPWLYAEVARVGLGIEPQNNTQVIGIEDSSAGVCAIRLANFPVVGLAGGNIAQSGTLGLCHHHCNDLNQILKIIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ1</accession>
    <name>A0A1U9NQQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GLUG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03266"/>
    <dbReference type="EnsemblBacteria" id="AQT70064">
        <property type="protein sequence ID" value="AQT70064"/>
        <property type="gene ID" value="STSP2_03266"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03266"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010699084" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1199" mass="128728" checksum="CE6149813BE5A49A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR7</accession>
    <name>A0A1U9NQR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70068">
        <property type="protein sequence ID" value="AQT70068"/>
        <property type="gene ID" value="STSP2_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03270"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="381" mass="45288" checksum="4FA513C2145BBDBA" modified="2017-06-07" version="1">MAKNKKRDRFFRRITHPRKIENDDRNYEYCRFTGEKPLPFKLSAVCMELANYFDGYDLGLDIGNKEIRHHMRREDANKLFFYWDKKPKDYATNRFSKRYWNQYRQQKYKEIDEERFHGGKVYEHITQQRKWYWTGNPFCSERLLGADIDNHTGDPEAVEPFLALFESFYPEAFYDRGSSGKSLHYYPKIDMLPLYEYWRNHASIRQAWIPYANEIIKYTGRIFKIYGNNVLCPAHVLKLRTDRNGKTRLDTEYLVEFDAFKGTYPEYKYYFNKGGSLVITEMVRNGVLHKFPDLFTIEDLVEFRDSPVFSIIHHLSVTIYLINQLLLSGCYSEKQRKIIEIVEKGIEPILVEHSVLFSTQKKNTVALNLRPPTSTSAVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS2</accession>
    <name>A0A1U9NQS2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03286"/>
    <dbReference type="EnsemblBacteria" id="AQT70084">
        <property type="protein sequence ID" value="AQT70084"/>
        <property type="gene ID" value="STSP2_03286"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03286"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="28901" checksum="DDA731115F6ADDDC" modified="2017-06-07" version="1">MTTERYDIEIRGLAVQVVRKDIKNLHVGVYPPDGRIRVAAPEHLSREAIRLAVVSRLGWIKRQQQSFHHQVRQSQREMVTGESHYFQGRRYRLDVVEHDGPAEVALPNNTTMELRIRPGTSRERRQEVLNAWYRDRLKEQVPALLEKWQGKVGVVVRDWRIRKMKTRWGSCNAEAGRIWLNLELAKKETICLEYILVHEMVHLIERHHDERFIDLMDKLMPQWRLHRDRLNQSPLAHEDWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS5</accession>
    <name>A0A1U9NQS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03487"/>
    <dbReference type="EnsemblBacteria" id="AQT70281">
        <property type="protein sequence ID" value="AQT70281"/>
        <property type="gene ID" value="STSP2_03487"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03487"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="35438" checksum="CB7C5B6FDA81D8A3" modified="2017-06-07" version="1">MAIVVGIDEAGYGPILGPLVVSCVSFSMPDDLVKGDMWETLKPAVGKAKRGLAGRILITDSKKAFTKATGTEHLQKAVLASLACTDRKPATAAQLLHHLCPDCFTRVKEYPWYDSLDKIMIDQAADQTYISASVLQRTMRSKNIQLNSLQSKCLDVAHYNSLVDKVQNKAAVLFTCVAQMIHKTFTEAPAGQTMQFLIDRQGGRVNYCQVLMRMFPQADFKIIKESETSSSYEMTQAGKTAKLHFVAKADLRFLPVALASMTAKYVRELLIGSLNDHFAAKCGTIKPTAGYWKDGTRYINELKNNLPPDDLPHSMLVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX8</accession>
    <name>A0A1U9NQX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03332"/>
    <dbReference type="EnsemblBacteria" id="AQT70128">
        <property type="protein sequence ID" value="AQT70128"/>
        <property type="gene ID" value="STSP2_03332"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03332"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040837">
        <property type="entry name" value="Bact_RF_family7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18849">
        <property type="entry name" value="baeRF_family7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="385" mass="43760" checksum="9DC2C83CA76B863B" modified="2017-06-07" version="1">MNLTNKDIRKLIQFEGTPCVSIYLPTHISSPDTMEGPIRLKNLFAETKRRLEEISPDLLEKMSKELGRINDMLNDIPFWQFQNHGLAIFMAPSFFEYYQTPISFEEFCYVGESFNVKPLAELLSEQTSAYVLAVNRREVHLYEVAGEKISEKQLRNTMKSIQELTRYDDSEKQLQHHSMPKGKAAGTGTMFHGQGTGSDNKEEKKRAGEFVKKVVEGVERELHADNTPVVLVADSYVAHLIYESNPEFNLQMEHVDENPHYISAADIHKKAKPILDKLANARLSNVVALYKNLTSSQKATDDPAQVIKAAYQGRIDTLLVDTNEYVWGNFDADKQEAVLDEHRQSHDQDLANSSVMHTLMHDGKVYAVSKSEIEHEAPMAAILRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX9</accession>
    <name>A0A1U9NQX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03431"/>
    <dbReference type="EnsemblBacteria" id="AQT70225">
        <property type="protein sequence ID" value="AQT70225"/>
        <property type="gene ID" value="STSP2_03431"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03431"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012279001" description="Alginate_exp domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="2">
        <location>
            <begin position="78"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="56770" checksum="09BBFD0FAD17D281" modified="2017-06-07" version="1" precursor="true">MKFALKILCLVVVAAMLTVPAFAADEKQEAVKTGQQASEQVTQYTGEDIPAPHTHMFYDADWLDKFHNPTEGVELGLDFRFREVYAENYTTLDKDFPAADNYAHYQRYRTRMSGKFNLSPDVDLNTRLVWEFFTWEKPSTRPQSTEFDEVLFDRLNFTFRNAFDMPLTIVVGRQDIILGNGWLVLEGTPADGSRTIHFDAVRATYDLQDEGDKLDLIYVQNYDKENKWLKPFSYNDARHFTQGQDERGAIVYWTNKLGPKAQTEAYYIYKEDRRSPRAAATVPNAEIHTFGGALQDAIDQNWSYRAELAKQFGQKGQTDLNAMAFNGRLKYSFNNECQSAVFMDYEYLSGDRPGTGNDEAFDTLWGDYPQAQRGGDLPIYVWVGESGNLGQMTNFHRLGFGHYFKPHEKWSLETLYNLYWADDNTLAAGATGGGGFPTYGSGRFRGQMFTAYLKYRCCAQLNAHFLVDYFVPGDFYADNSRDHGLFARFNVQYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ6</accession>
    <name>A0A1U9NQZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69936">
        <property type="protein sequence ID" value="AQT69936"/>
        <property type="gene ID" value="STSP2_03136"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03136"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="35" mass="4131" checksum="9092B1986019729E" modified="2017-06-07" version="1">MEVLFLLIIIAMLCWCDDDENELNVHDFEDEDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR14</accession>
    <name>A0A1U9NR14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70060">
        <property type="protein sequence ID" value="AQT70060"/>
        <property type="gene ID" value="STSP2_03262"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03262"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13544" checksum="7A7DAD89FF6E8B3A" modified="2017-06-07" version="1">MKMQAEYPARIDENGNLMRVRKAYDNGGKTLDRYTFTFEIYNSETGKWDVFTEGSNKSASKGDPSYQRIYCLSMSARPFSAQGVGQSGTCMEGKHLGKRVKFSELPEEVQRCVLQYMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRG3</accession>
    <name>A0A1U9NRG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pbpA</name>
        <name evidence="4" type="ORF">STSP2_03320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03320"/>
    <dbReference type="EnsemblBacteria" id="AQT70116">
        <property type="protein sequence ID" value="AQT70116"/>
        <property type="gene ID" value="STSP2_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03320"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="51"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="357"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="722" mass="81017" checksum="CE964FC570E552E9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRH2</accession>
    <name>A0A1U9NRH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase 2</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA2_2</name>
        <name evidence="13" type="ORF">STSP2_03330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03330"/>
    <dbReference type="EnsemblBacteria" id="AQT70126">
        <property type="protein sequence ID" value="AQT70126"/>
        <property type="gene ID" value="STSP2_03330"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03330"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT70126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23481" checksum="A881C816CAE64B09" modified="2017-06-07" version="1">MQLTIANKITIVRILLIAPYVISLLKMNQYENGQLLRYTAFAIFLLMCISDVVDGYMARVKKQVTRLGSFLDPMADKLLMMSSSILLATPATAVEGFVLPTEVAVLIIGKDLLLLLGFLVLYMMIGRVHVVPGVVGKFAAFLQLVMVASILIGPEMSKAIGVWPIIVSSMWWTAAALAILATMIYLNYGKKVIESEAYSDDEAASDRTDENGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRL6</accession>
    <name>A0A1U9NRL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminomethyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gcvT_2</name>
        <name evidence="2" type="ORF">STSP2_03554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03554"/>
    <dbReference type="EnsemblBacteria" id="AQT70348">
        <property type="protein sequence ID" value="AQT70348"/>
        <property type="gene ID" value="STSP2_03554"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03554"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="1">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39584" checksum="70C7BAA85C18B961" modified="2017-06-07" version="1">MANATPFESVHEKLGANFDIFNAWRMPADFGDPLVEQTAAYETAAAFDLSHFGRIQVKGDDAPALIDYLTATPTAGLTDGSVIWALLIAEPGNITDLVRITRVHNTYTILTSPAKRQLVLELAEKAQQTAGLADVKVSPITEKTAMLALYGPKAADILSRILPFEIDLEPGQVKGVNFFMMNLEVVRGSFIGTDGLELICPKGAASMAGTAIAKYRDRENIVPAGTLALDSALVQAGVPYSITNSTEGSKLTPADLNMTGLVDMNKDFIHKPALEASFKKGTTKTVAGLKTAKGTRHTDLRIQYDDAEIGFCPLTVPSPTLDSNLGLAVIDSEFTAFDEEIQVFGEDLVLPGQLTNLPFDPAANANVCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRP2</accession>
    <name>A0A1U9NRP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03401"/>
    <dbReference type="EnsemblBacteria" id="AQT70196">
        <property type="protein sequence ID" value="AQT70196"/>
        <property type="gene ID" value="STSP2_03401"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03401"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21897" checksum="2B5847A6FC1FC521" modified="2017-06-07" version="1">MAFTLELGSKAPDFSLCATDGNSYSLNDFADAKVLVIFFTCNHCPYVIGSDEVTRQTAEKYMPEGVKFVAINSNSPNTYEEDSYEHMVERMQEKKFPWTYLHDRTQEVAKTYGALRTPHFFVFDQERKLVYCGRGVDNPKDTDKMTDNDLDNALADVTAGRDVRKPLTNPIGCNVKWEGKDAHWMPADACDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE8</accession>
    <name>A0A1U9NGE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00147"/>
    <dbReference type="EnsemblBacteria" id="AQT67009">
        <property type="protein sequence ID" value="AQT67009"/>
        <property type="gene ID" value="STSP2_00147"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00147"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32340" checksum="CD032AB9E5760E7D" modified="2017-06-07" version="1">MSQEAADTGFSEELKRKAELANQVLNEVLASRTDIHPKLAEAMSYTLSAPGKRIRAAVIFWCSELIAGEVTDAAKIAAAAMETVHTYSLVHDDLPAMDDDDMRRGQPTCHRMYDEATAVLTGDALLTFAFDILANDVKNADISVKLIRTLAAAAGPAGMVGGQMQDLLSTSEKGDRETLEYIHLNKTAKMFGASAAMGAIAGGGTDEQVDSLYKYGLDIGLGFQVADDLLDISATSEELGKTAGKDQEQGKVTYPSLIGVERSRETAENLAADAIKRLENFGDRAQILRKLPRVLLDRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG9</accession>
    <name>A0A1U9NGG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthetic protein FliQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliQ</name>
        <name evidence="8" type="ORF">STSP2_00043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00043"/>
    <dbReference type="EnsemblBacteria" id="AQT66905">
        <property type="protein sequence ID" value="AQT66905"/>
        <property type="gene ID" value="STSP2_00043"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00043"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9466" checksum="CBD36163F5DC1253" modified="2017-06-07" version="1">MDTSWVVYLGKHTLETALLVAAPILGVCALVGVVVSLLQAVTSIRDMSLSIVPKLIGVGLTALLFGNWMLGVLLKFTGEIFGYIQAYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH6</accession>
    <name>A0A1U9NGH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase</fullName>
            <ecNumber evidence="10">2.4.2.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">arnT</name>
        <name evidence="10" type="ORF">STSP2_00182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.43" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00182"/>
    <dbReference type="EnsemblBacteria" id="AQT67043">
        <property type="protein sequence ID" value="AQT67043"/>
        <property type="gene ID" value="STSP2_00182"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00182"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103015">
        <property type="term" value="F:4-amino-4-deoxy-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="73"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="541" mass="59397" checksum="C69F0BC7CFC4A1D0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL7</accession>
    <name>A0A1U9NGL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67082">
        <property type="protein sequence ID" value="AQT67082"/>
        <property type="gene ID" value="STSP2_00222"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00222"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="23408" checksum="41D8D47675F2AC04" modified="2017-06-07" version="1">MVRANKKGLNKGSLPELSSSEQTRLNSFLSDTDKFYEYRIGHKTFRNLLTIDDSHGNAMLKMKPIAYLPSCEGLPQKLSGWFMKSNFFLESSEKEAFASAYMQISSSVRLFSESCEELLCLCEEDMHNFSINGSNYKGRYSISTKGKLSVAIFDAQDNCQLYVRADDRLLSEESKIFIRKNLEPSKKTCLSAIALLPEMNYRLDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM3</accession>
    <name>A0A1U9NGM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar protein FliS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliS</name>
        <name evidence="6" type="ORF">STSP2_00022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00022"/>
    <dbReference type="EnsemblBacteria" id="AQT66884">
        <property type="protein sequence ID" value="AQT66884"/>
        <property type="gene ID" value="STSP2_00022"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00022"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13469" checksum="052F8A05D121B0D1" modified="2017-06-07" version="1">MNGIGAYQETAVLTQSRSKLVVMLYDGAIKFMKLAIREMEAENFEEKGKYITKAQDIINELNAVLNMEAGGEIAVNLRKLYSFMHGHLARANAQNDPKLVEEVIECMDELNQAWKDICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ0</accession>
    <name>A0A1U9NGQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67112">
        <property type="protein sequence ID" value="AQT67112"/>
        <property type="gene ID" value="STSP2_00253"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00253"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="27858" checksum="02233C4330A5923E" modified="2017-06-07" version="1">MSEVYPSDNELLNLMSDEDTGVEYIPTGAAPYYLHFRKLLYRLLLATKRANDLRVFAEGGLEIGVKPGKYWSGTSLIEYGGSVGNALADEQASIFVYLDSAGQLVVDEYAAFPDMSQEVHVRLAVVRTSGGEVVEITDARDHHSISVPAMNSASSGVGTIEGHTVNDLLTADDSGSVHTNSGATGPVTLTLPAGAAAGTRFGFAVQASQVLYVDPGAAAILDDCGQTAGKSKYASTLGECIELMADANGDWVTISKRGVWMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS9</accession>
    <name>A0A1U9NGS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliC</name>
        <name evidence="6" type="ORF">STSP2_00096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00096"/>
    <dbReference type="EnsemblBacteria" id="AQT66958">
        <property type="protein sequence ID" value="AQT66958"/>
        <property type="gene ID" value="STSP2_00096"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00096"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="337"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="423" mass="43618" checksum="DE97D774BB486CB2" modified="2017-06-07" version="1">MLTIKNNLMSTNAARHLGSSYSALSESVERLSSGLRINSAKDDAAGMAVRELMRADIAVLRQASRNAQDGISLLQTMEGALSVMDGVLIRMKELAEQAATGSYSQDQRKIMHAEFTEMVEEIDRIANTHAINGIEMLNTADGSINIHIGTAETIAIDKSNMTSSGLGVSIGNSGYQAVSDHGVDSAGDTWLTVDDGGNGENLTLDIQFTDTTNGNESAVSVDFAGAGGGANYSLTQVVDAINAQAGFTMASVTTDSATGKQHLKVASEGSTADGVTITASTGANTTGAGGLAVGAGVTDAGVTEADGANGTDDGRMRTMEGAGINILDTASAEDALSVVGSAIHAKDTVRASLGYKMNRLESTRAVLDIQSENLLTAESRISDVDVATEMAKMTRNQVLAQAGIAMLSQANGMPQMALSLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU3</accession>
    <name>A0A1U9NGU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioD1</name>
        <name evidence="5" type="synonym">bioD</name>
        <name evidence="6" type="ORF">STSP2_00296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00296"/>
    <dbReference type="EnsemblBacteria" id="AQT67153">
        <property type="protein sequence ID" value="AQT67153"/>
        <property type="gene ID" value="STSP2_00296"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00296"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25651" checksum="99B8E47B715061D9" modified="2017-06-07" version="1">MAEELRLPSAKGFFVTGTDTGIGKTLVGGGIAKILRDAGKRVGVFKPVATGCQYHDEGLVNEDPEFLRRHSGSEHRLDTICPVGYVLPAAPCVSAEHENRPVDFQAMAKAYEKVVAESDAVIVEGAGGIRVPVDAGVDMLGLAKWFGLPVVIVARPDLGTINHTLLTVDCIRGAGLEVAGVVISGYDAFDSSIAEEQAAVVIEEWGDVPVLSVVPKDEDSDVASGKLGELTVEALGDADWAGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV5</accession>
    <name>A0A1U9NGV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_2</name>
        <name evidence="5" type="ORF">STSP2_00126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00126"/>
    <dbReference type="EnsemblBacteria" id="AQT66988">
        <property type="protein sequence ID" value="AQT66988"/>
        <property type="gene ID" value="STSP2_00126"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00126"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="445" mass="49803" checksum="9CA68807BBBBAB43" modified="2017-06-07" version="1" precursor="true">MKNMAGLSRREFLKSASIITASTCLPRFASAAESKRKNIVLIMADDIGFECFGCYGSEMYDTPNIDRLAANGIRFTHCYSQPLCTPSRVKLMTGKSNIRNYVGFSLLDGSQETFAHLLKSAGYKTCVAGKWQLYGAEHYSEETRGKGTLPEDAGFDTHCLWQVDKLGGRYWGPLLHIDGANRQFPKDVYGPDVCCDHICDFIKNAGEKPFFAYYPMILVHNPFPVTPDSENPESSDKQKNFADMVTYMDKLVGRIINTVKDEGLEKDTVVMFVGDNGTNRSIESKLGSQTIRGGKGKTTDYGTRVPFISSTLGETGSQVCDDLVDFSDFFPTVAGLAGASMPSDVKIDGCSFLPRLTGGKANPREAIFMYYYPWPIKGWKPETRFARDKRFKLYGDGRLYDVEKDVLEKHPVLESSDTEETRAVRLKLQKVMDSMPDEPEMIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH77</accession>
    <name>A0A1U9NH77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67281">
        <property type="protein sequence ID" value="AQT67281"/>
        <property type="gene ID" value="STSP2_00424"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00424"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010705406" evidence="2">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19638" checksum="AE863F29942BD25C" modified="2017-06-07" version="1" precursor="true">MKKQVSFLFMVAGVCLMTSLAAADLAEIGTEADPINVGTDQVLSAIHQDVDPFKGAAEIYVMNTGLEDWVGFKLEVFADAGVNIENVHFMDSALSGGMMSDPVVEVVGTGPLGHSYVIDNNAVGATITFDFDSNVVNGELVHFTVYTDNTTDQVNFGIAMLPVVPEPATMALLGIGALGLLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH91</accession>
    <name>A0A1U9NH91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purC</name>
        <name evidence="10" type="ORF">STSP2_00445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00445"/>
    <dbReference type="EnsemblBacteria" id="AQT67302">
        <property type="protein sequence ID" value="AQT67302"/>
        <property type="gene ID" value="STSP2_00445"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00445"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="15"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="297" mass="33545" checksum="2E2850A4B220BF63" modified="2017-06-07" version="1">MANVILQTDIPGVPVKHGKVRDIYDAGDHLIFVASDRLSAFDVVLKTGIPYKGQVLTQISKFWFDFLSDTIDNHVVSMDVEDFPAPFCNYPDQLRGRSMMVKKTEVLPVECIVRGYLAGSGWKEYQKSRTVCGIELPAGLKQCDKLPEPIFTPSTKAEQGLHDENISFDKAVDIIGEDKANFVRDTSLAIFKKARDYAESKGIILADTKFEFGLIDGKIILIDEVFTPDSSRFWPADKYEPGKNQESFDKQFVRNYLEETDFDKDGPGIELPTDIIEKTSAKYIEAYEKLTGQEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH94</accession>
    <name>A0A1U9NH94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase, constitutive</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ogt</name>
        <name evidence="7" type="ORF">STSP2_00432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00432"/>
    <dbReference type="EnsemblBacteria" id="AQT67289">
        <property type="protein sequence ID" value="AQT67289"/>
        <property type="gene ID" value="STSP2_00432"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00432"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
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            <end position="205"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22868" checksum="11A443FECCD0C894" modified="2017-06-07" version="1">MFVSIDPKVEICFTDSMFEVKYAIFSTQAGFVALVCAEDRLVRVFLPVASRVSAVSKVGIFCPSAREEQSIFPDLQEKIVRYFEGEYVVFREDAASALAGYSEIAGREDISSRLPDMVHMTPFRKDILLACNRVNYGRTVSYGELARLAGRPKAARAVGNALADNPFPIVVPCHRVIRSNGSPGGFMHNQPGAQDLKCRMLQLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC3</accession>
    <name>A0A1U9NHC3_9BACT</name>
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        <submittedName>
            <fullName evidence="10">Ktr system potassium uptake protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ktrB</name>
        <name evidence="10" type="ORF">STSP2_00310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="gene ID" value="STSP2_00310"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM5</accession>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="4" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67258">
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        <property type="gene ID" value="STSP2_00401"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07607"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="323" mass="38386" checksum="EF0A424B4016D80F" modified="2017-06-07" version="1" precursor="true">MKKTIFTLIVLSVLVVQAGSAFGARGGGRRIRVEPGEFVSYKNSICRFRLWGVRLSEEVERSIVFGVERIRDTYEDTFEFEFDDDFEVTITIIRTPEDFKAYQLAQIGEAISETGYFSAYHNETVVWANKSVKKMIGVLFHEANHLMVQQHIPYCPYWINEGLSEYFEGFNVIGRNKRVYLQNLRHQWVKKWLRDGFPISVEDYLGLSYREWQEFMDENVNAAYTMGYSLVYFMMSHPKTEELLKEILWELKEKKGLANSVRVVNETYPGGMRRFELHWKRWIPRARPYRPLRVLRERRNEKILEEAKEDEEKQEERAQADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP0</accession>
    <name>A0A1U9NHP0_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_00261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67120">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="866" mass="94119" checksum="A798B3A9A705B6DB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR4</accession>
    <name>A0A1U9NHR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14912" checksum="33D035CA10FDC4BE" modified="2017-06-07" version="1">MNHLLSFIDFDALVIIGPAAGITVYEFLRLRHRKKHGITAEQELAKIKKFPTWQIFWTIVTALLTLSLMMYWLVKTTDFPAYLAFIIVASVTLIDLALFAFLKKWCENQIKKNQQQDQNNETEQNPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR6</accession>
    <name>A0A1U9NHR6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">STSP2_00489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00489"/>
    <dbReference type="EnsemblBacteria" id="AQT67345">
        <property type="protein sequence ID" value="AQT67345"/>
        <property type="gene ID" value="STSP2_00489"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00489"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="37937" checksum="B818C9E45ECAFF5D" modified="2017-06-07" version="1">MNFKTLEWQGGIDGTLELLDQRKLPAVTEMLQIKTIPQLYEAIKTLAVRGAPAIGVAAAYGLGLALQDTDQSVGLRAALAHLDSAAAELARSRPTAVNLTWALKRVQKCARVFIEDNPSASVTDFREDVLDQAHTICREDQKMCREIGLNGQKLITPGSAIITHCNAGALATAGQGTALSPLYEAHAAGTPFTVYVDETRPLLQGARLTAWELNQQNIPVTLICDNMAASLMAEGKITAVITGADRIAANGDTANKIGTLNLALLAYHFGIPFYIAAPSSTFDIDTPMGEKIVIEQRDPAEVKCILDRAVSPATICAYNPAFDLTPAKYITAMITEKGIIEKPNKSTIAEHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY9</accession>
    <name>A0A1U9NHY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaBC_1</name>
        <name evidence="2" type="ORF">STSP2_00363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00363"/>
    <dbReference type="EnsemblBacteria" id="AQT67220">
        <property type="protein sequence ID" value="AQT67220"/>
        <property type="gene ID" value="STSP2_00363"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00363"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20251" checksum="DE54FD8E26FB3184" modified="2017-06-07" version="1">MTEGGLNGINVLLGVSGGIAAYKAADLASKLTKARASVTTVMTENACRLVRPKTFEAVTANPVFTSMWTGPEEYRIGHIDLADRSDLVIIAPATANIIAKAAHGISDDLLSTTICVCWEKPTLLAPAMNTRMWENPITQQNVQTLKDKLNFRLVGPATGSLACKTEGVGRMSEPADILHAACELAKTIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ6</accession>
    <name>A0A1U9NHZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">soj_2</name>
        <name evidence="3" type="ORF">STSP2_00277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00277"/>
    <dbReference type="EnsemblBacteria" id="AQT67136">
        <property type="protein sequence ID" value="AQT67136"/>
        <property type="gene ID" value="STSP2_00277"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00277"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="AMPK1_CBM" evidence="2">
        <location>
            <begin position="325"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43314" checksum="F445CA46C921448F" modified="2017-06-07" version="1">MRTIAVVNQKGGCGKTTVSINLASALAARGLRTLLVDMDPQGHCAVGLAVPEEQIEQSIYDVMVGESCGEPLRISEMVWKICDNYDLAPGSIDLAAFEQQMAGVEDREECLKRALSEVAGDYDYAVIDCPPSVGSLTFNAIKASSDVIVPVDTGYFSLHGLSKQLSTLSVLSQQCDNEINVMVLASMYDVRTKMGREILGELKKHFGDKMFKTVVNFNTKLKEAASLGQPISEYDPASKGCKDFNALADELVSTDSRAERAEMVESLQAKLDAISASADELLATAGVTETSTASATATMDEKLADFYGVRKLDDAVVFVSLYPRAEEVQIAGDFNGWQPEKTPMQKGEDGTWHVKLPLAAGRYRYRMVVDGQWQQDPYNEITEMNPFGECNSVVEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI17</accession>
    <name>A0A1U9NI17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67156">
        <property type="protein sequence ID" value="AQT67156"/>
        <property type="gene ID" value="STSP2_00299"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012097986" evidence="1">
        <location>
            <begin position="24"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="453" mass="49274" checksum="C4A013C3313B8759" modified="2017-06-07" version="1" precursor="true">MGRRYSVLTAVVMIAGMFLAGSAAEASFPDGLTQKVTHEGETITLDLVRESVRGKNFEVLVQKADGSFEKREVSAPRTYVGMVKEDPGAFAAGILRSDGQFKGKVYFSRGQTWFTLGDKVVGNRGLREPNFKMPSMSSVVPGTAGSKSYIFDVAVDADWRYFNRVGSVEKCVEMIEFSFVNVRIIYLRDTLLMPAIGRVLIRAEKEQCPYQGTNGTKILPIVRKEWNEKYKDVERDLVACVTPAIGGGVAWVGVVGTGNGYSVNGVAGDNSFDVVWRHELGHNWAVHDHHANSCEGPTLNCGNAYGRFSGAEVQSVFKHRDNKLNLLEKAGVYDTINMPPYAALDVIEESEEGYKLIVDVIANDHDANGHAVSLEGCDGESVKGGKIEIVEGSSGSREVVYTAPEKGLAGMDHFFYTVKDETGKIARGVVFVKGLKEESETAKKDGGGKEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI28</accession>
    <name>A0A1U9NI28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rocA1</name>
        <name evidence="12" type="ORF">STSP2_00574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00574"/>
    <dbReference type="EnsemblBacteria" id="AQT67427">
        <property type="protein sequence ID" value="AQT67427"/>
        <property type="gene ID" value="STSP2_00574"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00574"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="11">
        <location>
            <begin position="56"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="542" mass="60205" checksum="B2AB5B3155BE3023" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI48</accession>
    <name>A0A1U9NI48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-iminoacetate synthase</fullName>
            <ecNumber evidence="8">4.1.99.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiH_1</name>
        <name evidence="8" type="ORF">STSP2_00562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.99.19" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00562"/>
    <dbReference type="EnsemblBacteria" id="AQT67418">
        <property type="protein sequence ID" value="AQT67418"/>
        <property type="gene ID" value="STSP2_00562"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00562"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036355">
        <property type="term" value="F:2-iminoacetate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012726">
        <property type="entry name" value="ThiH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF1">
        <property type="entry name" value="PTHR43583:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00301">
        <property type="entry name" value="2-iminoacetate_synthase_(ThiH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02351">
        <property type="entry name" value="thiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="55"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40368" checksum="8CEFABF90467DD05" modified="2017-06-07" version="1">MIDNITTDQVRRHLAQPPGRYSIDRLMALLSPAASELLEEMAQQARQLTIQRFGRTVQMYAPLYVSNVCVNSCLYCGFNCQTEFSRTRLTIDQAVKDGKVIASEGFRHILLVSGEDTKYVTNDYLAELAQRLREDFSSVSIEIYPLDEAGYKNCFDAGIDGVTLYQETYDRDTYERYHIAGPKADYDQRLDSYDRAARAGMRRLGLGVLLGLADWRQETLALAEHAAYLMKKYWRSQVSFSFPRLRPAPHVAEEYEHLVGERELVQMMIALRLCFADAGIVLSTRESAELRNNAVNLCVTRISAGSKTNPGGYSEEDDSTEQFVIADDRDPSEVAKMIKRAGREAVWKDWDTSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE8</accession>
    <name>A0A1U9NIE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">STSP2_00666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00666"/>
    <dbReference type="EnsemblBacteria" id="AQT67518">
        <property type="protein sequence ID" value="AQT67518"/>
        <property type="gene ID" value="STSP2_00666"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00666"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023324632" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023324633" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="187"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="400" mass="41621" checksum="327531484EE1B980" modified="2017-06-07" version="1">MANMSVTAAKGFTASGVASGVKRSGKLDLGLVVCPEGAKAAGVFTTNKIVSPAVEVCREHIRRGKVYAAVVNSGNANCCTGQAGMDDAVTMCQVLAGEMGIQPGQVLIASTGIIGEKLPINKVKGGIFSAISELKDSGAAGDRFAEAIMTTDMRAKQAMRQFKIGSKVVTVGGTAKGAGMIGPNMATTICVLTTDMDISKGLLGKALRDAIGGSLNKLTVDGHQSTNDTALLLASGAAGNKPVSKQGTNYRKFAKAVREVCEDLTKQMGLDAEGATRIFKVEVKGAASQAEAGQAARAVADYDLVKCAVHGGDPNWGRIICAVGSCGVRLKPEKLTCRIGGVTVFRNGQPTRFDRKKVSEIIGQQEHVISIDLGAGRGEDFCWGCDLSKDYVTINADYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH8</accession>
    <name>A0A1U9NIH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease III</fullName>
            <ecNumber evidence="6">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nth</name>
        <name evidence="6" type="ORF">STSP2_00696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00696"/>
    <dbReference type="EnsemblBacteria" id="AQT67548">
        <property type="protein sequence ID" value="AQT67548"/>
        <property type="gene ID" value="STSP2_00696"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00696"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="5">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="25385" checksum="C11F519B1A5C5845" modified="2017-06-07" version="1">MNYEKLMEVFNLMHDRYGPQKWWPGDSEYEVAVGAILTQNTNWRNVESALENLKNANSLDPFTIDEMPAEQLATLIRPAGYYNVKAKRLKNFNHWLITEHDGQIEQLNNKSIDTLREELLSVNGIGRETADSIILYAVKKPTFVVDAYTCRIMLRHQFIDPYADYEQVKDFFESCLPADVELFNEYHALLVQVGKNHCKPKAKCAGCPLESLPHELDPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK3</accession>
    <name>A0A1U9NIK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67655">
        <property type="protein sequence ID" value="AQT67655"/>
        <property type="gene ID" value="STSP2_00803"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00803"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="46799" checksum="D5884677BE581D44" modified="2017-06-07" version="1">MPEQNNTRKLTKITITSRKQTILPVALILAITSTAHANSGTPLMWSSFLHLFFGNLFLGIFEGLLLVHFFKTKKNLAVILMILANYLSAWAGVFIIYDLIPTQSLGLSQVWPYFWKMVALTYILTLLLEYPFVALSFWRKPRWLPRSLKGTLIVQTISHFIIFGWYSLTSTANLYTDNQIVDLSEMSLPQHVTMYYISSDDGDVYSRSLTADAAPSKTFDLNSKGYGDYLFVRHSENNDGTYDLYACITSDKDYRDSETILIAESFTKTAAPTERDLEHDLEEYRTRYWFSPTDVPKLGPAQSSPWKFKTSIWSLMGLTAKNTKTEQSERVAFTTPFGGWLPKNATHLPTDKALFQLGIYPFNLKYLRGDQICIYDPNKKQLAKITHGKGPIAIIKDKPQKPTATPTNTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT1</accession>
    <name>A0A1U9NIT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY_2</name>
        <name evidence="3" type="ORF">STSP2_00560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00560"/>
    <dbReference type="EnsemblBacteria" id="AQT67416">
        <property type="protein sequence ID" value="AQT67416"/>
        <property type="gene ID" value="STSP2_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00560"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16589" checksum="D9C5453801DDB9AA" modified="2017-06-07" version="1">MLAAKTILFAEDNLGNFVLTKRHLRRWGIESSLIRFGSGQKLLDYVDNNIAQANCSGYIVILDIQLPGLNGVEVLKDIRRSKKSCELPVLMLSTTDRQTTIDKCMQIGADAYFVKPLSKPAFFRALDRLGMPEDNLDDSGISQAQHVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU1</accession>
    <name>A0A1U9NIU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">hcp</name>
        <name evidence="7" type="ORF">STSP2_00855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00855"/>
    <dbReference type="EnsemblBacteria" id="AQT67707">
        <property type="protein sequence ID" value="AQT67707"/>
        <property type="gene ID" value="STSP2_00855"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00855"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="550" mass="60645" checksum="0AB4816713388816" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ60</accession>
    <name>A0A1U9NJ60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67768">
        <property type="protein sequence ID" value="AQT67768"/>
        <property type="gene ID" value="STSP2_00917"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00917"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="16374" checksum="CD4D7E34D6629025" modified="2017-06-07" version="1">MAKMKNPLRRWSRVATFLYFLYCFKAVYDIYVYSGNDTVLGSPASSGGWMAPVVPFGFLGTAAFLWFYKRRMRYAWHALMASAIAIPSVYWFCSYANIYYQDPGLNEVDFAVWLYLLWHFYGLKRPYEDYLARVGLPSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ66</accession>
    <name>A0A1U9NJ66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67865">
        <property type="protein sequence ID" value="AQT67865"/>
        <property type="gene ID" value="STSP2_01017"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01017"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="10837" checksum="BA04D63A4B56E950" modified="2017-06-07" version="1" precursor="true">MIRRRFWVFGIVVMMLVGGVSGGGPAVAAGTAEAGGNGVANEGENVVIRGRVFDDAGRTIGGADITVYRSGWAWQAETVGWQVLGKLKANATGEFGVPIKCPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB3</accession>
    <name>A0A1U9NJB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68023">
        <property type="protein sequence ID" value="AQT68023"/>
        <property type="gene ID" value="STSP2_01177"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01177"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20423" checksum="CB0746CD7107DF9D" modified="2017-06-07" version="1">MRWSASRSDEYCSRDSTAEPCPCGAAKNCPVSDGSAGLPDTFSWSVSKLPRTPDAACVAEHIPRAFSDGHRKTPASAERRVFGYRSQAASWDGRYDSNFGPAEDEPPAVRTRRMIWSARLKRAGLRICESVFFRLEIGVVALFPCLCPPELDLLFMQDGPECFNADRRNDLFLDKIFTQFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS5</accession>
    <name>A0A1U9NJS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01220"/>
    <dbReference type="EnsemblBacteria" id="AQT68065">
        <property type="protein sequence ID" value="AQT68065"/>
        <property type="gene ID" value="STSP2_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01220"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20965" checksum="60BF9AB8EC8F404F" modified="2017-06-07" version="1">MENRFDKSHDVNKLFMGYVLSSQKDIYVYILSLVICKEDADDILQDTLALMWSKFDEFEPGTNFVGWGKTIARYKVMDFLRKNKRSRLHYDSDVLKIIEAKVPESDVFSDRKDAMQNCLKKLPDKDIDVLKMRYSHGMTFKQMALKFGISKQSAYRKVSRIHALLVKCINQVLSSGPSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW2</accession>
    <name>A0A1U9NJW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67796">
        <property type="protein sequence ID" value="AQT67796"/>
        <property type="gene ID" value="STSP2_00945"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00945"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013047085" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21546" checksum="C890A3938F136D73" modified="2017-06-07" version="1" precursor="true">MKLTIKTLLALTVLFTASYAQASPVALDVTNHSESDLRAVLWGGLAETDFVYDDGMRTWQSSWQSDFWSLQATIIEEYRMGAMLATLKVEAQHLTGLHDGEVAPGFVLDTMHINLTGDPRFAISAEPVRISNKIHPGAVEHHDVLHTFVMDLDQNLPGLLSGDGQIYAVIEAAHVMPEPATLVLIGVGALALAGCRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK05</accession>
    <name>A0A1U9NK05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68239">
        <property type="protein sequence ID" value="AQT68239"/>
        <property type="gene ID" value="STSP2_01395"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01395"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="42239" checksum="0E6837EDA34C7F02" modified="2017-06-07" version="1">MAGKPKTPTYHNGRLLDAKDDKGNRVHVAFEQSYSGGRGGYVLRKTRKGKTVRKKCFGTHKNREKALANAASLFEKYVGTVASERTPIAQHNLQVEKTGDYKITWIHLYENDADIIEKLSNFYNEWNPLTTEEGEEPISIKDLHYDVYSNDYELQAIYNWWDILSARETTGEDETIEPVFDIPRPFFNFCHWESHIFTVFNWAKHKPLILEHICKQVNSHANNTQLMTKEELKEELFAIGMVVEGDDEWIESKLKEAREYWTDERRREYERETKKLYPSSKVYWVENKFRVITEDEFNQHFEYPLLKTDGVNVTRNRRKVDKFYIMDEAIKLIENNPSEFANYTKISGITKPSQKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK12</accession>
    <name>A0A1U9NK12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01233"/>
    <dbReference type="EnsemblBacteria" id="AQT68078">
        <property type="protein sequence ID" value="AQT68078"/>
        <property type="gene ID" value="STSP2_01233"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01233"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012730656" evidence="1">
        <location>
            <begin position="22"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="851" mass="90738" checksum="008949F9BA571CF8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK18</accession>
    <name>A0A1U9NK18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67856">
        <property type="protein sequence ID" value="AQT67856"/>
        <property type="gene ID" value="STSP2_01008"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01008"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="70" mass="8152" checksum="19919F6F1047BF6B" modified="2017-06-07" version="1">MSSFCENRLQKLYSGIFCGKDSKFNIVCFDVIEYLAYKECQLGCFGYYLRLATSFDDFFGFILEIRVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK49</accession>
    <name>A0A1U9NK49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dagK</name>
        <name evidence="2" type="ORF">STSP2_01459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01459"/>
    <dbReference type="EnsemblBacteria" id="AQT68301">
        <property type="protein sequence ID" value="AQT68301"/>
        <property type="gene ID" value="STSP2_01459"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01459"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="315" mass="34696" checksum="E774E7B92FB59A64" modified="2017-06-07" version="1">MNISKEGYILFIINPSSGKSSSKLMFHEFRSYLEEKGYSIKIAFTESLEHAQELARKAAVEYDCKLVVAAGGDGTVREIVQGLEGSDKPMMIVPAGTENLLANEMGYDEKGKTLIKAFEGDASRDLDLGKANGRCFTCVAGFGFDANVIDMVNERREGHINHLDYFWPIWRTFWAYKFPDITVSVDGEQIHSGPGILFVGNISRYAVGLEILQNADFGDGLLDVCIYKCESQIQLLKHSVFTLSKRHINASDVVYRQGKIVEIGGDPQVVSCQLDGDPGPDLPVKIRLIPQAVKVLVPPDAKPAGIRTRLVRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK64</accession>
    <name>A0A1U9NK64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative electron transport protein YccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yccM_3</name>
        <name evidence="4" type="ORF">STSP2_01360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01360"/>
    <dbReference type="EnsemblBacteria" id="AQT68205">
        <property type="protein sequence ID" value="AQT68205"/>
        <property type="gene ID" value="STSP2_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01360"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="31381" checksum="A173EED285A70A54" modified="2017-06-07" version="1">MSMAEKSKSRKFFEKIVPWRMWFQTAFLLVWLDPMGMRMHSVCSPVFHCYACPLSTFACPIGVMAQFSAIQMIPFVAIGTVVAIGALFGAMVCGWMCPFGLMQDLAAKMKTPRWRIPAWMGHFRYVVLIGTVFAIPYFFGSSDPLFICSWCPAGGLEAALLRGIVPNMLKVTVVVLFVGAIFFTVRPWCRVLCPLGAMFGFLNRFSILSMKLDDYKCTSCKRCHSMCSYGHVPDKSPNSSQCIRCLECTKCGTQALEMGTVFDKGGGEKSDSGTDEDSKKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA1</accession>
    <name>A0A1U9NKA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67946">
        <property type="protein sequence ID" value="AQT67946"/>
        <property type="gene ID" value="STSP2_01098"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01098"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="54" mass="5891" checksum="902EA96CE1D51451" modified="2017-06-07" version="1">MIKVICDKCGQEITDATDVSTVVEDGQAKHYHKSGCFTDARATLTQTTDTTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR9</accession>
    <name>A0A1U9NKR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mmgC</name>
        <name evidence="10" type="ORF">STSP2_01708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01708"/>
    <dbReference type="EnsemblBacteria" id="AQT68542">
        <property type="protein sequence ID" value="AQT68542"/>
        <property type="gene ID" value="STSP2_01708"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01708"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020964">
        <property type="entry name" value="Acyl-CoA_dehydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036797">
        <property type="entry name" value="Acyl-CoA_dehydrogenase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12186">
        <property type="entry name" value="AcylCoA_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158494">
        <property type="entry name" value="SSF158494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="174"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="282"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AcylCoA_dehyd_C" evidence="9">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="596" mass="65590" checksum="225B8EC9A9B82A69" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX5</accession>
    <name>A0A1U9NKX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68374">
        <property type="protein sequence ID" value="AQT68374"/>
        <property type="gene ID" value="STSP2_01534"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01534"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="322" mass="36002" checksum="EE20938BA4371AE4" modified="2017-06-07" version="1">MKKKGFTLIELLVVIAIIAMLMAILMPALGKVKRMAERIVCGSNLRGLGNAVAVYASDYDDEYPVHHFDADNTWRHKRSSWQLPDRTPERNDAAVAVSSSLYLLVKEADVDTKVFVCKSADEQAFEGETPQVRAEGVDLIEVWDFGDTPYDNLSYSYQLPYAPSGGRARPVSGSSDPSMAVMADKNPWTDSTLTVDGDVTSEDYMSKTFSWANSASNVEDLESLPKWVEALSNSGNHQREGQNVLFNDMHVTFHKRADVGVNQDNIWMKYRTNETTEWAKRVGEQSAQPVLNNFDKFLPHDREDNVLVSDENPANNDVIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL41</accession>
    <name>A0A1U9NL41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signal peptide peptidase SppA</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sppA</name>
        <name evidence="5" type="ORF">STSP2_01822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01822"/>
    <dbReference type="EnsemblBacteria" id="AQT68653">
        <property type="protein sequence ID" value="AQT68653"/>
        <property type="gene ID" value="STSP2_01822"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01822"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="156"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="39953" checksum="2245E9A280DF2621" modified="2017-06-07" version="1">MEHDNNNGNPPREDGNDQPPVNPHANPAQPIYIQMPEQKDKRSGWRVLWRLLFTVSIVLNIFLFLLVIGISVMYVPAAGGMVREELVREGDAQNKIAIVRLEGMITTETSDMFRNKINAVRNDDTVKAVIVRTITPGGAVSSSDQIYHMIRQLKAEKDIPVIAFMQTVAASGGYYTSVACDHIMAEPTVITGSIGVIMNHFVLKDLLEQKLGVDSVVVKSGEKKDWPSMFSQPSEEQKEYLREKLIKPSYERFVSLVAEGRSHVLSEEEVLELADGSIYTAEEALEKKLVDSVGYVDSAIQKAQEMAGISGARVVEYKRPITFMSVLGASNKTPWDLDPEMVHELTTPKLMYLWDGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL48</accession>
    <name>A0A1U9NL48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermonuclease</fullName>
            <ecNumber evidence="2">3.1.31.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuc</name>
        <name evidence="2" type="ORF">STSP2_01832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.31.1" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01832"/>
    <dbReference type="EnsemblBacteria" id="AQT68663">
        <property type="protein sequence ID" value="AQT68663"/>
        <property type="gene ID" value="STSP2_01832"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01832"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="24302" checksum="338F8FAE1965DEAF" modified="2017-06-07" version="1">MSRNKRRALIGMGVLLVFGVSMLDRWGGDGLREVVTRGRPEGADAEKYHRKSFAVNEIIDGDTVDIDVPDGKWPDTRVRLLGVDTPETKSPRYGEMYYGPEATEFTRQLVAGKEVTVIIDTVSDVRDRYGRLLAYLELEDGRVLNAELVRKGFAYADLRFSHSRYEEYENLMIEAVKEGHGLWEEVERDELPQWLRREWPGILKLREKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL60</accession>
    <name>A0A1U9NL60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">waaA</name>
        <name evidence="11" type="ORF">STSP2_01842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01842"/>
    <dbReference type="EnsemblBacteria" id="AQT68673">
        <property type="protein sequence ID" value="AQT68673"/>
        <property type="gene ID" value="STSP2_01842"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01842"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="33"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="48651" checksum="07662DC46B461D4A" modified="2017-06-07" version="1">MEYILNTIYLLAAILVAPKALYRAFKQGRYRTGWAQRFGRIDRKHPEKPCIWIHAVSVGEVNQTRKLITDLTDRFPDHEIVISTTTDTGHARAQKLYADDHTVFFYPLDFSPFVRRAFKNLNPSACLLIELEVWPNFAAIAHKKHIPVIVVNGRLSDKSYPVYKKIKPAARWMFRKLELILAQTDEYAQRFIALGCDPQKVRVTSSLKYDTAQIADKLPGSDELAKQIDLGDEPFWVVGNTGPDEEWIALDIFTELRTHPDLQNLRMAVVPRKPERFDEVNAMIERSPYSHIRYSTIKDGNTSAEGKPDIILGDTMGDLRKFYSLAKIVFVGRSLVPMGGSDMIETAALGKCTIFGPHTFNFKQTVDALLAADAAIEVADAQELKRATLKCFTEPEYASRIASNARNVIIENQGATKKTIKAVADIIHNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL88</accession>
    <name>A0A1U9NL88_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_01735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01735"/>
    <dbReference type="EnsemblBacteria" id="AQT68567">
        <property type="protein sequence ID" value="AQT68567"/>
        <property type="gene ID" value="STSP2_01735"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01735"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="74"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26903" checksum="0A65F102E7C66EDA" modified="2017-06-07" version="1">MSAENLKRALEQHVALDAFLTGDFGLKGDLPMPAAFEQAEPELVDKAGKLEEIAEQIRQCCKCGLNETRKNAVIGEGNPDAELVFVGEAPGADEDEQGRPFVGRSGKLLTKIIAAMGLSRDDVFICNILKCRPPENRDPKPDEIVDCMGYLQQQLDIIRPQVIVALGAHAARTLLSTNQGIGKLRGRFHEYTFSDEEPPVKLMPTYHPSYLLRNYSQDNRRRVWEDMQKVMQELGLELPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB8</accession>
    <name>A0A1U9NLB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer ATP-binding protein TraC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01905"/>
    <dbReference type="EnsemblBacteria" id="AQT68733">
        <property type="protein sequence ID" value="AQT68733"/>
        <property type="gene ID" value="STSP2_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01905"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="66"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="694" mass="76942" checksum="F949F8A6C2F79CB6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ0</accession>
    <name>A0A1U9NLJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68604">
        <property type="protein sequence ID" value="AQT68604"/>
        <property type="gene ID" value="STSP2_01772"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01772"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8231" checksum="ED0A2233DD35284A" modified="2017-06-07" version="1">MYSVSLKNMMHKAHLPHGHDIAVKTGHLLHDQRFWAIIALIAVMAFIVVLAILIEPTATEVESPPLIPSYPMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM7</accession>
    <name>A0A1U9NLM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">STSP2_01556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01556"/>
    <dbReference type="EnsemblBacteria" id="AQT68396">
        <property type="protein sequence ID" value="AQT68396"/>
        <property type="gene ID" value="STSP2_01556"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01556"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32280" checksum="FF1D7C1092BA7D85" modified="2017-06-07" version="1">MKNRGKLPVWLKRRMPASATYGDTRNTLKDLELETICTNANCPNRGQCWDRGTATVLILGNVCTRNCKFCSVGHGKPEPPAADEPDRIAEMSKRMGVKYLVITSVDRDDLPDGGAGHFAAVVNRCRELNDGMQFELLTGDFRDSMDESIEILGTALPFVFSHNVETVPSLYTKARPGGNYERSLDLLRKFKNRFSDTPTKSSMMFGLGETDEEVIEVLKDLRSVGVDRVAMGQYLKPSKESLDVVEYVEPAKFDWWGEKAKELGFSWVMSSPFTRSSYHAELERTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ5</accession>
    <name>A0A1U9NLQ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01837"/>
    <dbReference type="EnsemblBacteria" id="AQT68668">
        <property type="protein sequence ID" value="AQT68668"/>
        <property type="gene ID" value="STSP2_01837"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01837"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="1">
        <location>
            <begin position="155"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="53228" checksum="68FD519AFAA84B3E" modified="2017-06-07" version="1">MFGVDSIPVRTSVRIRYKDGVIDCQRKTDETVGISLLWPVDGFGKLMLSTTLLPERERPYILNVELARAKLMEITLKREDWTLLEEDETFADLMRDARHLFVEAVRNIHDEAKAASLADESLKKALVYAEKLAEKYSETFLAARFRSRGLGRHSLGCRIDPGLMGNEVYSEKLFDMFGFVTVPICWREIEKVEGHYDFSKLDQCIMGMRGKKMAVCGGPLVRFAPEYLPQWLMEGDYSFDEIRDAAFKFVTNIVGRYVKKVHAWRVVSGINALNYFGFKFDQMIEVTRALCLSAKAADKHSRRIVDVLNLWGEYYSREKDTSPPMVYADTLVQSAVSFDAFGIEMNFGSPASGMHVRDMMQISSKLDEFSMMAKPVHVCSVSVPSEYHESDELAGIWHRKWDQGLQSRWAEQFYKAALGRSFVSTVTWGDLADADGTIVPTGGLLDEKMGPKKIYKSVGKIQKLIGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM00</accession>
    <name>A0A1U9NM00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="7">SDH</shortName>
            <ecNumber evidence="3 7">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroE</name>
        <name evidence="11" type="ORF">STSP2_02003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02003"/>
    <dbReference type="EnsemblBacteria" id="AQT68827">
        <property type="protein sequence ID" value="AQT68827"/>
        <property type="gene ID" value="STSP2_02003"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02003"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="254"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="8">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="7">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="390"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="413"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="535" mass="58268" checksum="A76277841385486F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM11</accession>
    <name>A0A1U9NM11_9BACT</name>
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        <submittedName>
            <fullName evidence="2">ADP-heptose--LPS heptosyltransferase 2</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaF_1</name>
        <name evidence="2" type="ORF">STSP2_02126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02126"/>
    <dbReference type="EnsemblBacteria" id="AQT68949">
        <property type="protein sequence ID" value="AQT68949"/>
        <property type="gene ID" value="STSP2_02126"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02126"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011910">
        <property type="entry name" value="RfaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02195">
        <property type="entry name" value="heptsyl_trn_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37457" checksum="34834A08138C093A" modified="2017-06-07" version="1">MSDKKQNILIWLPSPMGDAVLCTPALRALRRHFTNANITFLAAPTVRAVLSPSSFNDDWIDLAGGTLQLVRKLRNRRFDKAVLFKNSFGSAMTVYLAGIPERIGYTRDMRGLLLTKKITPARDTNGKFKPGSMVDYYLNLCDKLTCDITERSLELQVDNSAVPAMLTKLPAIVKSQGPLAILVPGGAFGPSKCWPTQRFAKLADILTEQHNATVIVSVAPNEAEQKIAAQICDKAETNIISLADISLSLGELKALIARSNVVVTNDTGPRHIAIALKRNVVSLFGPNNPEWTQTGYERETQIIGQAECVPCDEPVCKRPSHECMESITVDQVHSAVKEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM71</accession>
    <name>A0A1U9NM71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis sensor protein PhoR</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoR_1</name>
        <name evidence="6" type="ORF">STSP2_02084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02084"/>
    <dbReference type="EnsemblBacteria" id="AQT68907">
        <property type="protein sequence ID" value="AQT68907"/>
        <property type="gene ID" value="STSP2_02084"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02084"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="247"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51821" checksum="5325ED8FC84E01BE" modified="2017-06-07" version="1" precursor="true">MHRSCLFVLPVVAITAILAQAAAFFIEPAASKLIIAISGLTGLAALSGLLFYLVMAGKSVSHITKTLNSGKSIDRKDFKAGALGGLVKAVSAYVEQLQQRADQAEHDLSDMQVSVGLLERQKKNIEEIIYSIRDAVIVCDDRDRIVMANSAAEEVLDFDANESGMRALDKIVAWPELVKLVQTSRRSKQRHVKHELSLELHGEPKTYDCIISCVIDDNQEVAGIVAVMHDITKEKEISQMKNDFVSHVSHELKTPLASINAYAEMLVDGEADDQETITQFCTIIQSQADRLNRLIEEILNISRIESGLIKVDKEDVSLTMLVQEAAKMIKSYAGEKSIGIDMPAPIIYDQVNADKDMMSQVIINYLSNAVKYTPAGGEVSVQSQVDEADGFVRVTVTDNGVGIPPEDVDHVFDKFYRVESNKKYAKGTGLGLNLVKQIVEKVHGGRVFVTSEVGKGSTFGFEVPLAAKAALSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA4</accession>
    <name>A0A1U9NMA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">STSP2_02220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02220"/>
    <dbReference type="EnsemblBacteria" id="AQT69039">
        <property type="protein sequence ID" value="AQT69039"/>
        <property type="gene ID" value="STSP2_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02220"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19593" checksum="2D7B308D4640BBD1" modified="2017-06-07" version="1">MNSVDQINIDQDYMRKAIDQAYIAEENGDVPIGCVIVHEGRVIAKAYNEREQLNDPTAHAEIIALTQAAEFLGTWRLHGCTVYVTLEPCPMCAGALVLARMDRLVFGTEDPKTGSCGSIYNIVQDDRLNHHIENTKGVLQEECREQLQAFFRNRRLKKSLEQATSDAKDVRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA5</accession>
    <name>A0A1U9NMA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02034"/>
    <dbReference type="EnsemblBacteria" id="AQT68858">
        <property type="protein sequence ID" value="AQT68858"/>
        <property type="gene ID" value="STSP2_02034"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02034"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="584" mass="68272" checksum="F5ADECEA75EC931D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI2</accession>
    <name>A0A1U9NMI2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02185"/>
    <dbReference type="EnsemblBacteria" id="AQT69007">
        <property type="protein sequence ID" value="AQT69007"/>
        <property type="gene ID" value="STSP2_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02185"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42709" checksum="5AEBF72890D26334" modified="2017-06-07" version="1">MKVSKRAQSVPPSATIAVTSRAKEMAAEGIDVVSFAAGEPDFDTPNFIKTAAIEAINAGKTGYTAANGILKLRNAIAEKLASDNELDYTPDQIIVNIGAKHSVYTALQAVIDPGDDVLLPAPYWVTYPEAVKLAGGKVKVIHTEKENSYKLTPELLESSITDRTALLILNSPNNPGGFSYTPQEFADLAEVLEDTDVMVLSDEIYEKLVYGGTKFVSFAAVSDDAYERTLTINGFSKAFAMTGWRLGYTAGPLSAIRAMGRLQSHMTSNAVTFVQEAALAALADKTGTVESMRVEFEKRGNYMAKRLNELPGIQCHQPTGAFYCFPDVSSLYGRTMGQAPVKDSMSFAQVLLEQANVAVVPGEPFGCPDNVRLSFACSTEQIEKGLDRIEKWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML1</accession>
    <name>A0A1U9NML1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69192">
        <property type="protein sequence ID" value="AQT69192"/>
        <property type="gene ID" value="STSP2_02379"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02379"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012707963" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1053" mass="117614" checksum="B87A413C1F261799" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM2</accession>
    <name>A0A1U9NMM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative anaerobic sulfatase-maturating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02156"/>
    <dbReference type="EnsemblBacteria" id="AQT68978">
        <property type="protein sequence ID" value="AQT68978"/>
        <property type="gene ID" value="STSP2_02156"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02156"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034491">
        <property type="entry name" value="Anaerob_Ser_sulfatase-maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00285">
        <property type="entry name" value="anaerobic_Ser-type_sulfatase-m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="43678" checksum="1EE4F4D7FC5385C9" modified="2017-06-07" version="1">MRPFSLLIKPTGPDCNIDCRYCFYTCKTTLFGGGRHRMSEEVLEKMVNDFLGCGFPQNSFAWQGGEPTLMGLDFYKKVVELQEKACGAGQNFTNSLQTNGILLDDEWCEFLAEKGFLVGISIDGPKKFHDKYRLDHGGNGTFDRVMAAIERCKKHGVQFNILTLLNSYNVEHPDELFDFYVENGFKFLQFIQCVEEDPETGEIADFSITPEQYGDFLCRIFDRWVDHGVRKMSIRTFDSMISQCLGMGATECTFMPKCADYVVVEHDGGVYCCDFFVENEHRIGNLLDRNLGELAGDSIKRRFNRQKRKLANKCLVCRHLDICRGGCPKDRKKGYDDGITYFCEGYKKFFDHSMGEFWKLASMIQQENLLAERQEVWNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM6</accession>
    <name>A0A1U9NMM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor kinase CusS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cusS</name>
        <name evidence="2" type="ORF">STSP2_02026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02026"/>
    <dbReference type="EnsemblBacteria" id="AQT68850">
        <property type="protein sequence ID" value="AQT68850"/>
        <property type="gene ID" value="STSP2_02026"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02026"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17452" checksum="B6D4B77C1045ED00" modified="2017-06-07" version="1">MAQKKNLEFKINYNSGYREVEAVPDQIGIVLRCLLENAAKYSFNGKPNDKRKISVRFNNVYLGEKRALEISIQNYGCPISLEEASSRRIFQLGYRGEYSGEGGRQGTGTGLYLVDRITTAHKGRIDVHSKPDGPAENNQAVNTFVLTWPRYFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN1</accession>
    <name>A0A1U9NMN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT_2</name>
        <name evidence="3" type="ORF">STSP2_02166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68988">
        <property type="protein sequence ID" value="AQT68988"/>
        <property type="gene ID" value="STSP2_02166"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02166"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="43773" checksum="6606BDBF3933475F" modified="2017-06-07" version="1">MTDQDYFSYSVDDKIYPGGDGVKLSMTDMLAYFEKHGAMRVSDLHIKIGTQPAYRVDGDLVRMRGAVMTDDLARKLIYPLIGPREVDRLNKDCSVDCSYRHGKLQYRINVFRENDGLSAAIRALGIEIPEPKDVGFPSNMWQEVVNRKQGLMLFTGITGAGKSTTIASLINYINKNRACRIITLEDPIEYVFDQKHSVISQREVGRDVNSFSDGLRAMMREDPDVIFVGEMRDPETVAMTLTAAETGHLVFSTLHTRDVTGTITRILDYFPSGRQEEVRSQLSLGLAYVISQKLVPRKDGQGRIVAMEILNNTYAVSNLIRHAKIEQLYSLLQTKTRDRVDENMITLERHLARLVKQGKVDLLEAKKWANDQKSFVDAMNVVSDIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN3</accession>
    <name>A0A1U9NMN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carnitine catabolism transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdhR</name>
        <name evidence="2" type="ORF">STSP2_02368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69181">
        <property type="protein sequence ID" value="AQT69181"/>
        <property type="gene ID" value="STSP2_02368"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02368"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="30589" checksum="793D545787CFF13B" modified="2017-06-07" version="1">MFKEYLSSPESYSAISGMSLHSVWYVDADNSYIIKPNAGSGKVALRTLTGSGTVIYKDGRVLSPDANSLLFFDFAEIAEYRCVDKKWRFWWFEFDTHDVFEFVMDQTFTVLPIPDEGERLNQIFLSLHSYGAAYSKLATAGFCYLLYEYGLNHQIRQQNEPYLDCVNKIITLMNERLERPLTVSEMADAANMSDRNFRKIFKRITGRSPKIFYNKLRMQHARDLLRRGYSVSRVSHLLGFSSPFCFSNAYKEHFGLRPSDTVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ8</accession>
    <name>A0A1U9NMQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC_1</name>
        <name evidence="3" type="ORF">STSP2_02376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69189">
        <property type="protein sequence ID" value="AQT69189"/>
        <property type="gene ID" value="STSP2_02376"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02376"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="32631" checksum="9B8E66881A94FCAF" modified="2017-06-07" version="1">MSDSALKRINVGAYDKPFSGVGIEYYPLGGEFDHTGLLIHEVGFLPRNSNWNFPGVFSPFWRLYYNSEPGHGISFQGDFYHLKPDHLMLIPNHQLFHCLGKNPVPTFWMAFSTDRLISPIQKTPILLKPTSTTRSLIEDIKGLIVRNTYYSPTDQIYRNSLALLNVVIANTDIDWKKENPAMLNKLLDYIATNCDKQLSNSHLAQVACMSIEGLSKMFRTHMGTSPAAYVTQIRIKQASYLLLNTSESIDRIAEKTGFPNRNYFSRVFKKISNQSPAQFRQLHHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS7</accession>
    <name>A0A1U9NMS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69135">
        <property type="protein sequence ID" value="AQT69135"/>
        <property type="gene ID" value="STSP2_02322"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02322"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234091" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21868" checksum="DBDC8BACB530DE79" modified="2017-06-07" version="1" precursor="true">MKKILALCLLVAVCGSVQANLLPNASFEDWGTDVNGWDMPNGGYGLWTEDWGGLGSTGICTGDAQDGSVSFKLEETSWSAGALTYGLGQLGTTNGLGWYHVGGFVKASGTTPVDATIGIDIFAPDWSAFWWGGGADVVAALNSTEGQAGEWVYVGFDFEVTDPTANYNFRVKTDNGSFLVDNVQLVPEPASMALLGLGSLLALRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX0</accession>
    <name>A0A1U9NMX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gmhB</name>
        <name evidence="8" type="ORF">STSP2_02127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02127"/>
    <dbReference type="EnsemblBacteria" id="AQT68950">
        <property type="protein sequence ID" value="AQT68950"/>
        <property type="gene ID" value="STSP2_02127"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02127"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="39316" checksum="0E06EB203BC13041" modified="2017-06-07" version="1">MGQKAVFLDRDDTIVNDPGYMNHPDQVELLPGAGEALVQLRQMGYRIVIITNQSGVARGLVTEEVLQEIHHRLRELLAKENAYVDGIYYCPYHPEGVIDHYRKESDLRKPNPGMLQHAAKDLDIDLSRSWMVGDSFRDIAAGKSVGCKTILINSPAKRKIPGPDDVLPDREAVNIKEAANIIRMVDAHGQKSRPETKPQTAERSQNTQQQESTTKTQKTQQQTGTRSQPVTPLRTAKPKQTESAQQDTAPKTQKSEETKVQRPKEDESVTKMFEEIVSLLKKDGRSDLYDEFSILKVVAGIAQGLVLFCLLVSLWFLMDSTKSGQAVQTAVLYGMVFQLMAISFFMMSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ0</accession>
    <name>A0A1U9NMZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA_10</name>
        <name evidence="1" type="ORF">STSP2_02354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69167">
        <property type="protein sequence ID" value="AQT69167"/>
        <property type="gene ID" value="STSP2_02354"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02354"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17134" checksum="F191B33AC997E6E4" modified="2017-06-07" version="1">MTVSGLAVYYWYHYDGLGSVVALSNSSGSIVEKYSYDAFGVTTIHSPVNGIWGDGDDVTLSSSAYGNPYMYTGRRYDPETGLYYYRARMYSPTLGRFLQPDPIGYADGMNMYTYVGNNPLNFVDPWGLCGKDHDEAETEEILAEVRAFPWHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ1</accession>
    <name>A0A1U9NMZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02458"/>
    <dbReference type="EnsemblBacteria" id="AQT69269">
        <property type="protein sequence ID" value="AQT69269"/>
        <property type="gene ID" value="STSP2_02458"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02458"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019962">
        <property type="entry name" value="CHP03663"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41710">
        <property type="entry name" value="PTHR41710"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03663">
        <property type="entry name" value="TIGR03663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="531" mass="58268" checksum="F3D4986D81664E83" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ5</accession>
    <name>A0A1U9NMZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02392"/>
    <dbReference type="EnsemblBacteria" id="AQT69205">
        <property type="protein sequence ID" value="AQT69205"/>
        <property type="gene ID" value="STSP2_02392"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="399" mass="46020" checksum="D26F07BF15EB7FC3" modified="2017-06-07" version="1">MANYYLKDFLTLKPKDLLQLYFGNKGLLMDFAWGQELIVDDLAEAILALTDPALVQYEFRTIYKWANEGGIAALIDEARSPLHGSLELGEKLGELENEHARAMYMWLNHDDVFSHAIDLREWESRRGKNHYYVGPGIPCDGEDEQVRQKLGATVAEYFKRQSKGKKCKVEYYMRTNPDRHYFFANPEDSVKGFRKYRDDSEDVIIRAAYRPIFQVIFEYNAEDGDLAVHARSKKAKDKMFEAMCTEVLGFKEPPNAATEVFDLSCLKDGKFRFAEDPEMPVESITLKMVMLNLNKGTDQRITLEASPHKGDNRQVEGMMQKTYLAHGVKLEDVFVRKAKIEIKFKPVNMHKVGRITFTVGYPQYSDLSDDEKSEMARRYLRKWGILVKHKAMSESTNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN30</accession>
    <name>A0A1U9NN30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csp_1</name>
        <name evidence="3" type="ORF">STSP2_02093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68916">
        <property type="protein sequence ID" value="AQT68916"/>
        <property type="gene ID" value="STSP2_02093"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02093"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9674" checksum="E2BA8456A799BD95" modified="2017-06-07" version="1">MAKGKVKWFDPKKGYGFVLNDEGEDVFVHYTSIIGDGFRCLRNGQTVEYDEIESDKGLQGRQVRIDELKQAMSERSVPEPEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN66</accession>
    <name>A0A1U9NN66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein OmpV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ompV</name>
        <name evidence="5" type="ORF">STSP2_02528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MipA/OmpV family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02528"/>
    <dbReference type="EnsemblBacteria" id="AQT69339">
        <property type="protein sequence ID" value="AQT69339"/>
        <property type="gene ID" value="STSP2_02528"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02528"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010583">
        <property type="entry name" value="MipA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38776">
        <property type="entry name" value="PTHR38776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06629">
        <property type="entry name" value="MipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="29184" checksum="DB30CDE45A1AB5C0" modified="2017-06-07" version="1">MSFKSYVILMGVVLFAGSGAGETIRTVEREDRVFQAGPGVLISDKAQEGVDTDVWPIPAVYYREGRFSIFGPRARYVLHYEEDDLLVGATAQMRNEGYEDDDSRVLRGMGERRATLEAGLTVRKYFGWGRVTAEWTSDVLNEHKGHEIELLANRWFNNAFDVEGLRMLPTVGVNWRSKQLNDHYYGVEADEARGFRPAYEVGSTVGLLTSLRVDYPLNDQWNLFSSVSAEWFDGEITDSPIVGQHYKLTAVLGAMYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN89</accession>
    <name>A0A1U9NN89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69363">
        <property type="protein sequence ID" value="AQT69363"/>
        <property type="gene ID" value="STSP2_02552"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02552"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13309" checksum="D843BEA5CDA49F1C" modified="2017-06-07" version="1">MVTLVKIVGLLVVIDAVIILVSPGLYRQVLEFVKLHRLFYISGLLKLITGIVFFMAISAEPAPDSPLLIGLLGLTACVSGLFLFAVRNEKLSGISGWLINKPDWFLRAAGVLVGIWGGLAVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA3</accession>
    <name>A0A1U9NNA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69315">
        <property type="protein sequence ID" value="AQT69315"/>
        <property type="gene ID" value="STSP2_02504"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02504"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10340" checksum="94951F3DE1E670D0" modified="2017-06-07" version="1">MELTNLQTHVGLVGRDSLVDQVRNYLTKRFMEQHKLNPIPSVIQSLKDLQVNRESSYSHALRTAEFNLDGKKKACGHLGASVRNPGHRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE3</accession>
    <name>A0A1U9NNE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02621"/>
    <dbReference type="EnsemblBacteria" id="AQT69431">
        <property type="protein sequence ID" value="AQT69431"/>
        <property type="gene ID" value="STSP2_02621"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02621"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19973" checksum="D79AE027F750634D" modified="2017-06-07" version="1">MSNLPLRAVKVDEGLILRSSGDVIDGVEIRRAKVIPDERGRLGEIMRADDPWFEKFGQVYFTTTYPGIVKAWHFHKKQTDHFYVPKGLIKVALYDERKESSTYGTVNQIYLGEHCPGLVRIPPGIQHGWMCVGNEEAYIINIVSEMYDYNSPDEYRTGPHDNHIPYDWERKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF0</accession>
    <name>A0A1U9NNF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,5-anhydro-D-fructose reductase</fullName>
            <ecNumber evidence="3">1.1.1.292</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">afr</name>
        <name evidence="3" type="ORF">STSP2_02544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.292" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69355">
        <property type="protein sequence ID" value="AQT69355"/>
        <property type="gene ID" value="STSP2_02544"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02544"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033712">
        <property type="term" value="F:1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36013" checksum="CB4C59E475DA8099" modified="2017-06-07" version="1">MKSVRWGILATGQIARKFAEGLQALPDAELVAVGSRKLETAKAFAEEYNIPRAYGSYAELTGDPDIDVVYIATPHPAHAQNTLQCIDAGKAVLCEKPFALNATQARHMIQAAAEKNIFLMEAMWTRYIPLMLEIENILEQGTIGPPKMIHADFGYSGDWEPDGRVLSPHLAGGALLDVGIYAISLASMVYQRDPEKVAALAHMASTGVDEISAFILSYEPAALAILSCAVGASTPGEATISGSKGYIKIHSPFWCPSKATVSIDEGKTETIEVPFEGNGYNYEAAEVHRCLREGLTQSPKMPLEETLRIMGTMDNIRKQWNLKYPMEHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF1</accession>
    <name>A0A1U9NNF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH-type transcriptional repressor NsrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nsrR_2</name>
        <name evidence="1" type="ORF">STSP2_02663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02663"/>
    <dbReference type="EnsemblBacteria" id="AQT69472">
        <property type="protein sequence ID" value="AQT69472"/>
        <property type="gene ID" value="STSP2_02663"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02663"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16969" checksum="581A0AF81A6BCBCA" modified="2017-06-07" version="1">MTVSKTEMVILRELQVEIIRRNTDYALRAMIFLANEGRSVPARDIAELCGMPYQITAKLLQKLHKTGLVSSKMGPKGGFELSRGPEEIKVTEIVEVIQGPITVNKCTAGSEGCVRSGSCGLCRKLRELQRDVDGFLDGVSLLDFTIERAERAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH8</accession>
    <name>A0A1U9NNH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaphase-promoting complex, cyclosome, subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69502">
        <property type="protein sequence ID" value="AQT69502"/>
        <property type="gene ID" value="STSP2_02693"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02693"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160475" evidence="1">
        <location>
            <begin position="22"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="787" mass="88233" checksum="DE883D2B77E9361E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ6</accession>
    <name>A0A1U9NNJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02556"/>
    <dbReference type="EnsemblBacteria" id="AQT69367">
        <property type="protein sequence ID" value="AQT69367"/>
        <property type="gene ID" value="STSP2_02556"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02556"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="81" mass="8398" checksum="E446EF9CECBFB0AD" modified="2017-06-07" version="1">MADNGKKPLSGISSGQTVIFSNVDAGCELRSRLAAMGLVPNARLKVVSNGGFGPFVINVRGSKVVLGRGVAHKVMVEEACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK0</accession>
    <name>A0A1U9NNK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02713"/>
    <dbReference type="EnsemblBacteria" id="AQT69522">
        <property type="protein sequence ID" value="AQT69522"/>
        <property type="gene ID" value="STSP2_02713"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02713"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032638">
        <property type="entry name" value="Porin_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16930">
        <property type="entry name" value="Porin_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024783" evidence="2">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="402" mass="44712" checksum="A9838C038C380E3D" modified="2017-06-07" version="1">MKQKVQAALAAIMIMAMAGLASGDEISELRKQVEMLSKKLEKLEAQQQQQKSVFEEQIDKVAAQKSEAKLPDSLKWAETLKFYGDFRYRHESIDDETASEQRDRNRIRARLGVKAKVNDEFGVNFRLASGDDDPVSTNETLDDSFSTKDIRLDRAYAIWTPNWSDPTTIQMGKMGVPFFKAGGNQLIWDDDLSVEGVSANYGWSLNDNTSAEVTGAGFWVDERSSDVDTSLWGIQGLINRDLSSDSSVTAGATYYDYGNIEGIPTTTIGTLSSDYNIFEALAEYSTKINSVPVKVYGNWVNNTAADTGEDTGYLLGMTYNKAKKQGTWQLGYQYRDLEQEAVVGAFSDSDFIGGGTNGKGHKFSFAYALAKNTTAGVTYFMNEKGDDETDYDRLQIDLKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP2</accession>
    <name>A0A1U9NNP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative teichuronic acid biosynthesis glycosyltransferase TuaH</fullName>
            <ecNumber evidence="1">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tuaH</name>
        <name evidence="1" type="ORF">STSP2_02645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69455">
        <property type="protein sequence ID" value="AQT69455"/>
        <property type="gene ID" value="STSP2_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02645"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="45580" checksum="EBAEC9FE72D30FB7" modified="2017-06-07" version="1">MISGHDIICFGPTDWWSGNPSCTTHIMRLLAQQNRILYINPFSSDLSGRIRKGIAARMLRKTRSILKCYRRESESLHIYSPVFLPFQGKHHLDSLNNTILRHQLSTVVKLLKFKRPIVWVENVRSAEMISSMKPKLTVYHVSDLFAKCKYTANKVQLGKREQAVTRMSDLLICVSQRLYDLKRSQHSNVHYIPHGVDYSLFKEAAASGSKHPAATNVPSPIIGYYGSLTPNNDIETLKHCADKLPSYSFILAGQITGGDYEDLLAKPNVHYIGKQPYEQIPSLCASFDVCLLPWRVTDWIRHCNPLKLAEYMASGRPIVSVRIDEVASLYNELISVADSPQSFCDAIVHELTNDTEARSKQRQQLAQDRSWTAQVDKISELIASRLEDEAADRDTFRMRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT4</accession>
    <name>A0A1U9NNT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69394">
        <property type="protein sequence ID" value="AQT69394"/>
        <property type="gene ID" value="STSP2_02583"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02583"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14415" checksum="CE076CC207200687" modified="2017-06-07" version="1">MVDGLVEVKAGIAKSIAFLFLVAFGLCFVYRVSEVHGPEAKYGCGLAIVVTVSTSFVSVLPVLFAIASGFFVVGIAAIIGSVVRLFLTVIGFIIVAAMGMSNGWFFLFGSLFYLVFLLIETLLALRLMKKEADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP13</accession>
    <name>A0A1U9NP13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-W factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigW_4</name>
        <name evidence="4" type="ORF">STSP2_02847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69653">
        <property type="protein sequence ID" value="AQT69653"/>
        <property type="gene ID" value="STSP2_02847"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02847"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="20227" checksum="305409A942C0EA01" modified="2017-06-07" version="1">MTTRKDEKLVLACKQGDRDAYGQLVERHYKRVFSVCMGLTGDVHDAEDIAQDAMVKAFTRIESLEDGGQFGSWVVRVARNLCIDFFRRRTRGREIVAEQAEGLKKSGADSEKNAVDLEGAIKMLPQENRLPLMLYYFENKSPKHIAKELGISDSGVYRRLRHARQELHAILTQEGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH4</accession>
    <name>A0A1U9NPH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-xylosidase</fullName>
            <ecNumber evidence="6">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yicI_2</name>
        <name evidence="6" type="ORF">STSP2_02812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02812"/>
    <dbReference type="EnsemblBacteria" id="AQT69618">
        <property type="protein sequence ID" value="AQT69618"/>
        <property type="gene ID" value="STSP2_02812"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02812"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527462" evidence="4">
        <location>
            <begin position="30"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121833" checksum="E688B56F71060245" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI3</accession>
    <name>A0A1U9NPI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">STSP2_03029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03029"/>
    <dbReference type="EnsemblBacteria" id="AQT69831">
        <property type="protein sequence ID" value="AQT69831"/>
        <property type="gene ID" value="STSP2_03029"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03029"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7997" checksum="E1DCFA8503959DE0" modified="2017-06-07" version="1">MAKKDAIKLDATVVEALPNAVFKVELENGHQILAHVSGKMRMHFIRILPGDQVTVEMSPYDLTRGRIVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK6</accession>
    <name>A0A1U9NPK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02842"/>
    <dbReference type="EnsemblBacteria" id="AQT69648">
        <property type="protein sequence ID" value="AQT69648"/>
        <property type="gene ID" value="STSP2_02842"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02842"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="37582" checksum="750F248B7BA37BFF" modified="2017-06-07" version="1">MSSNRLNGKSQTYIQDKVLLFLKGVLMGICDLIPGISGGTIAFITGIYERLINSVKAFSPALFRSVFRAITDSGTETRRNLRENIQKLDLGFLLVLLSGIATAILLGSRLIKYLLEVHFSYTLIFFVGLILASSRIIYRNIQNHKLKNVAFGLLGFVIGIVLGFIVPKEMMDNYLYVFIGGFFAISAMFLPGISGAFILLIMGLYEFIIDCLHNVFKSMDYIFVFGLGALFGAFAITRIISFLFRKDKCKTLYVLLGLVIGATSIPLKRIYQDASFSPGNILLMLFFFLVSFFLVYAVSNYKKFYTNKTSVNQAAECMTTGDEPCCKPPKSPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK8</accession>
    <name>A0A1U9NPK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">STSP2_03072</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03072"/>
    <dbReference type="EnsemblBacteria" id="AQT69872">
        <property type="protein sequence ID" value="AQT69872"/>
        <property type="gene ID" value="STSP2_03072"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03072"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT69872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26240" checksum="8CDD9CDF697B4CF8" modified="2017-06-07" version="1">MRIDIMTLFPEMFAGPLGYSIPKRAQEAGLVDIELTNIREFGLGNYKKVDDTPYGGGPGMVMMCEPVFNCFEHVEQLDPEPGRVLMMSPAGRKLDQKLVRELSGEKRLILLAGRYEGFDERIQQGLGAEPVSIGDYVLSGGELVAMVVVDSVVRLLEGALGHEESATEESFSEGLLEYPHYTRPVEYKGMRVPEVLMSGNHAKIELWRKEQALERTKKWRPDMLDDCDGTDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT6</accession>
    <name>A0A1U9NPT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69943">
        <property type="protein sequence ID" value="AQT69943"/>
        <property type="gene ID" value="STSP2_03143"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03143"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7463" checksum="B1E526B7912DCC18" modified="2017-06-07" version="1" precursor="true">MFLMTCTIRRMAGRCGGDAAVSPCPAATYTAGPSQPQERGMVCGGAQKALNNFLFITLHTVNKGLMKISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX5</accession>
    <name>A0A1U9NPX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69875">
        <property type="protein sequence ID" value="AQT69875"/>
        <property type="gene ID" value="STSP2_03075"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03075"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="667" mass="76046" checksum="7113752F66BCB1AA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX7</accession>
    <name>A0A1U9NPX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02759"/>
    <dbReference type="EnsemblBacteria" id="AQT69566">
        <property type="protein sequence ID" value="AQT69566"/>
        <property type="gene ID" value="STSP2_02759"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02759"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="292"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="862" mass="98634" checksum="1C4B8DE3C14FC170" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX9</accession>
    <name>A0A1U9NPX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rpsC</name>
        <name evidence="13" type="ORF">STSP2_03045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03045"/>
    <dbReference type="EnsemblBacteria" id="AQT69847">
        <property type="protein sequence ID" value="AQT69847"/>
        <property type="gene ID" value="STSP2_03045"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03045"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26602" checksum="6A5AB364EA9F4E23" modified="2017-06-07" version="1">MGQKTSPIGFRTGITLPWQSTWFAPKANYGEFLVEDERIRHHVDVRFNRQPPFAAVSKTEIARTRNEVKVTLFTARPGMVIGPRGSEVDKLRGELEELIDRKVSVNVVEVKEPALNAQLVAENIAQQLQKRGSYRRAMKQACETSMNAGAKGVKVICSGRLGGAEIARTETQKLGSIPLQTLDANVDYGYATARTTYGAIGVKAWVYKGKFGEEITPKPRARKGQRPRRGGKPGGPGKPAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ03</accession>
    <name>A0A1U9NQ03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02885</name>
        <name evidence="3" type="ORF">STSP2_03507</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02885"/>
    <dbReference type="EnsemblBacteria" id="AQT69690">
        <property type="protein sequence ID" value="AQT69690"/>
        <property type="gene ID" value="STSP2_02885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70301">
        <property type="protein sequence ID" value="AQT70301"/>
        <property type="gene ID" value="STSP2_03507"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02885"/>
    <dbReference type="KEGG" id="alus:STSP2_03507"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="71"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="26938" checksum="FF02D7B8D650AC2C" modified="2017-06-07" version="1">MALSYYPTMINKYKKRSKISEAKFRQIVKLFALDIEATKIAELTGLSRKTINTILYKIRIRIAEYCQQQSPFDVGEIEIDESYFGARRVRGVRGRGAKGKHIVFGLIKRGGKVYTQVVRNCSKSTLMPIIKQKVDKDSIVYTDGFKTYDGLVDFGYKKHYRVKHGENEFAEGHNHINGIENFWAIAKGRLNKFRGISKGTFALHLKECEFRFNHRHDDLYKLLLKILRKNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ19</accession>
    <name>A0A1U9NQ19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">asnS</name>
        <name evidence="8" type="ORF">STSP2_03087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03087"/>
    <dbReference type="EnsemblBacteria" id="AQT69887">
        <property type="protein sequence ID" value="AQT69887"/>
        <property type="gene ID" value="STSP2_03087"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03087"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="134"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="503" mass="57470" checksum="D39930B4819B2A34" modified="2017-06-07" version="1">MAVQKTTISELKDHVGEEVSLQGWLYNSRSSGKLVFLILRDGTGLCQCIVEKAEFAEEKFDELKRLGQESSLVVTGTCREEPRSVGGYELSVTGAEVVCEATDYPITPKEHGVDFLLKHRHLHLRSQRQWAIGKVRHTVIDAIRRFFNDNGFTLIDTPIFAPTAGEGEQTLFEVDYFGQPVYLAQTGQLYLESAAMSYGKVYCFGPTFRAEKSKTRRHLTEFWMVEPEVAYIDLPGLLELGENFVSFVVQQVLEKNRGELETLGADIPHLENIKPPFVRMTYTEAAELLKSDKAAKFMAEQLESFKARKTEIEKHIADIEAEEKSGGVKKWKREKNARMLIELRTELEELEKKIENNPKHAKLAAEFNWGKDLGGSDETIISQMHDRPVFVTHYPRSAKAFYMKTDRSNTDVVENFDLLAPEGFGEIIGGSVREDDYDYLMKRIDEEGYDPENYSWYLDLRKYGSVPHGGFGLGVERTVAWITGEKHIRQCIPFPRMMDKMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ67</accession>
    <name>A0A1U9NQ67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69927">
        <property type="protein sequence ID" value="AQT69927"/>
        <property type="gene ID" value="STSP2_03127"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03127"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9119" checksum="BC76A24E3A70287B" modified="2017-06-07" version="1">MIIGVAVTPEFYDTAIESRCVQMAVDDGSAAIEPCEQPADEPEQQHKQKQPAGRDDAVRDENKSEPAQTHGRPGDEPPFPSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ84</accession>
    <name>A0A1U9NQ84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mnmE_2</name>
        <name evidence="3" type="ORF">STSP2_03094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03094"/>
    <dbReference type="EnsemblBacteria" id="AQT69894">
        <property type="protein sequence ID" value="AQT69894"/>
        <property type="gene ID" value="STSP2_03094"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmE_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="187"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="387" mass="41136" checksum="E70E85B9D366808D" modified="2017-06-07" version="1">MSSLVFAAVVTGRGVSAIASVEVRGAGAARVLGEMFRTGGGEARAFEAGRLYTGDIVAGERVLDNVVVAVRGEDDIAINCHGNPLIVEEIVRELAGRGVQVIEAEELVKDKRRGESMIAAESRVVQCRAATLVGAEIAAYQTGDGLAAVVERWSDEIERGELGKVRADCGELLAVSERARLFVEGCRIVLAGPPNGGKSTLMNTLAGRQRSIVTEQAGTTRDWVSSDFRIGGLAVELVDTAGLDEVLAGGDVLEERAQQRTKELIEGADMVLYVVDASEGRRIERTGLEGLGRCAVAVLNKADLGRKLGVEDVGYEFDGAVEMSAVQGSGVDELCGEIMRVLEVEDYKIGQAAAITDRQRVLLERLLEAGDAEKAKLLIAELRDGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ96</accession>
    <name>A0A1U9NQ96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69686">
        <property type="protein sequence ID" value="AQT69686"/>
        <property type="gene ID" value="STSP2_02881"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02881"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9656" checksum="9A2A1EDF1C3BD98D" modified="2017-06-07" version="1">MACRERGGGAFLVVEIMITIINTLFCSHVYRRFVLSDGYLILQGRVCLPGGALLFGGIPEVGCGDCLECAQSVTICFLVTAWVGRVVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG8</accession>
    <name>A0A1U9NQG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70065">
        <property type="protein sequence ID" value="AQT70065"/>
        <property type="gene ID" value="STSP2_03267"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03267"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="29471" checksum="1C3820AFEDC345D6" modified="2017-06-07" version="1">METDALVRSRRYLYYCYMDYILKEGREPTFEEYRHDYRRDVGTGAEDEEDIKRLNYVYETNIEKMRRYSYGSLGQKIEQMGQKLGLTQDDVNRMSSYDRKLYLREVAITAVWIELCLTNADYLGKKKWWSLNKAQHYGRELTVPMTSLENFIRCMQEKGLNKNGCNPRKAKALRELLAEHGWIQCVDDSVIIASQNGGKGGRARRYVLLPEHPGYKRFERIVGKERIEHWQEFREEQLICRGNRGLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL0</accession>
    <name>A0A1U9NQL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein YttP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yttP</name>
        <name evidence="3" type="ORF">STSP2_03226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03226"/>
    <dbReference type="EnsemblBacteria" id="AQT70024">
        <property type="protein sequence ID" value="AQT70024"/>
        <property type="gene ID" value="STSP2_03226"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03226"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="24874" checksum="DD1335070B45EA73" modified="2017-06-07" version="1">MGGYSNSEQTREALIDAAGELAAEFGFANVSTRAIAEKANQNIGSIHYHFGGKDKLFEEVMRSALQRYRDNPISKILDNFAGRLDEPSVQSEAIRQIVHRSIICAFGLKERWWNERVLYQAVHSKNPLRDLLRRELIDPDIKDMMRLLKHIKPDISEEDALLHIKILEGPVILHAQHFEESLSESRRSYTEEYLKKLEDVLVRSFQLYWGLPLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL3</accession>
    <name>A0A1U9NQL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid hydroxylase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03404"/>
    <dbReference type="EnsemblBacteria" id="AQT70199">
        <property type="protein sequence ID" value="AQT70199"/>
        <property type="gene ID" value="STSP2_03404"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03404"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="33133" checksum="99DBB381EA6FCE2A" modified="2017-06-07" version="1">MSTYGQIALPLSLLGVFVILLTAEWKFPLRKRKDAFKSRFLVNVLISVLALLTGALLVRTTAFNLTGWVEGKRYGLIGLLGLGPAASFAVGFLLMDLTFYYWHRATHKFAFLWRFHQVHHIDLDMDVTTSFRFHPGEVALSVPFRCAQAVLLGVGPATWVIYVGCFQAATMFHHSNLRLPIRLERIVNKVIVTPRMHGIHHSTRRKEVNSNYSTIFRWWDQLNRSLLLNVPQNSINIGVVGYLDRTSNRSSRLLTMPFQKTPLPKKTKKTDQNKTQPEQTPKYRNILMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL4</accession>
    <name>A0A1U9NQL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">STSP2_03428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03428"/>
    <dbReference type="EnsemblBacteria" id="AQT70222">
        <property type="protein sequence ID" value="AQT70222"/>
        <property type="gene ID" value="STSP2_03428"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03428"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
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        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="56405" checksum="8BDFE29240AB4022" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM2</accession>
    <name>A0A1U9NQM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70077">
        <property type="protein sequence ID" value="AQT70077"/>
        <property type="gene ID" value="STSP2_03279"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AQT70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10733" checksum="5B994E31A97924D1" modified="2017-06-07" version="1">MNKFISPLAGAINLTEEEGFEPPEACASAVFKTATANTQGVEDTGLTAIDGDRLQTSLQIRAACELPLELAEVIRAWPELPEHVRLAVMALVRSAVPESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP8</accession>
    <name>A0A1U9NQP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase hydrolase-like protein</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blh</name>
        <name evidence="2" type="ORF">STSP2_03349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT70145">
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        <property type="gene ID" value="STSP2_03349"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03349"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="367"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="455" mass="50594" checksum="168628D8505D7629" modified="2017-06-07" version="1">MFLEKIKSEGIAHLSYMLGSGGQAAVIDPRRDIDVYLQMAREKGVNITHIFETHRNEDYVIGSLPLMDKTGSQIYHSGATKFSYGQSVSEGNEFEIGDLKLKILETPGHTFDSISIAVIDSNFSDDPVGVFTGDALFIGDVGRTDFFPDRAEEVAGLLYESIFNKLLPLGDDVILYPAHGAGSVCGSGMASREFSTIGYERKHNPVLQKTDKGEFVNYKVNEHHYQPPYFKKMEEYNQFGPPEKDMQKPVKRMNVSTFEKSQDSGMLVLDARSPEAFAGCFIPGSLAIPLNMIPAYAGWLIPYDQPIGLVVENKADVGQAVRHLCRLGYDNVVGYLGQGIHQWEKSGLIYDMIPAVHAQELKKRIENQTDFTLLDVRTVSEFEKGHLPIAQHMYLGYLPRQIDQLDRNKLITTFCGSGRRAIIAASYLKMNGFRFVEDCLGSMAACSKLGCPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY6</accession>
    <name>A0A1U9NQY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylate/amino acid/amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70235">
        <property type="protein sequence ID" value="AQT70235"/>
        <property type="gene ID" value="STSP2_03441"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03441"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32195" checksum="1254DFD728379E43" modified="2017-06-07" version="1">MGKSVLKSDLLLLLTSFVWGTAFVAQRKGLDYVGPMTYNAWRFGIGAVILLPILFAGLRREAVKAPAQRINWIWGALGAGAMLFAGASLQQIGLLYTTAGKAGFITGLYVVLVPIGGLFLGQRAGVSLWIGAGLSVAGLYLLSGVGSAEMVTGDFLVLAGAFFWAGHVLLIGHLAGKADPFRVAIVQFAAVAVLSMIASVVFESADLRDIVDAAVPIAYGGLLSVGLGFTMQVVAQKDCLPGHAAIIMSLETVFAALAGWIVLHEMLEPTGIAGCGLILAGMLAVQMPIIYSRRQQSISSSLDKEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR03</accession>
    <name>A0A1U9NR03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ruvB_4</name>
        <name evidence="7" type="ORF">STSP2_03252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03252"/>
    <dbReference type="EnsemblBacteria" id="AQT70050">
        <property type="protein sequence ID" value="AQT70050"/>
        <property type="gene ID" value="STSP2_03252"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03252"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36865" checksum="7534CD1450BA3249" modified="2017-06-07" version="1">MAENQVGNDVNQIEIVSLSKIRGQKKVTDLLKVNLDAYFQSRQNGNPGSFGPVLLCGHSGTGKTLVAKALHAELANLDLIETNGEMLSSSGELTSILLSATENTTVFIDECQGMHPRSQHILLTALSERVIYVPRRANNKSKQAIPLENFTLIMATTHEYFLQAALRNRMRIYARFEYYSLEDLVEIIRQRALALNWNIESGQVLTEIAKRSKKTPRIALNRNLQQCWNVAAAKGKESIGMDDVLEAFRLIQIDQLGLDELERNYLRILHQNGPTALNVISSKLALPTQTVKSVLEPYLLQENLIGKNKCSHREITFLGQEHIQNCQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG22</accession>
    <name>A0A1U9NG22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheA</name>
        <name evidence="8" type="ORF">STSP2_00017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00017"/>
    <dbReference type="EnsemblBacteria" id="AQT66879">
        <property type="protein sequence ID" value="AQT66879"/>
        <property type="gene ID" value="STSP2_00017"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00017"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="419"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="619"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="754" mass="80914" checksum="B112FDBD505A918C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP9</accession>
    <name>A0A1U9NGP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67109">
        <property type="protein sequence ID" value="AQT67109"/>
        <property type="gene ID" value="STSP2_00250"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00250"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15872" checksum="0036ED27E7386CD0" modified="2017-06-07" version="1">MANAMIELPFYVSRAGEPLEGAAAGMSFLNLMTVGGVDKSGSQPMIEEIGGGWYKFNVAYGTAPFDEGDLVGVIDADAGGSLGLCLEERYIPVEARLDYYALNRLVCRMSQDKLNGDMVLKNLDGEGMLMLKIVEGESQVERLPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT4</accession>
    <name>A0A1U9NGT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="399" mass="43141" checksum="15EC25FDD9C092E1" modified="2017-06-07" version="1">MSEKLDTKNMSIFERYLTVWVLLCIAGGIVLGKVAPGVAQTLDGMAIYVNKAPVISIPIAVCLFFMMYPIMVKIDFGEVVKAGKSVKPVGLTLILNWAIKPFTMYGIAVFFLGTLFYGFIGPDAMDVVKLPMGAGVEVGDVYGAGTVIMQDGVKMLEVPLWRSYLAGCILLGIAPCTAMVLVWGYLSRGNDGHTLVMVAINSLTMLVLYGVLGGFLLGIGKLPVPWEALLLSISVYVALPLAAGYFSRRLIIAHKGEAWFKEKFLHMLTPVTIIALLVTLVLLFSFKGEVILDNPLTIVWIAVPLFIQTVLIFAIGYGLSKLLKLRYEDAAPTAMIGASNHFEVAIATAVMLFGLSSGAALATVVGVLIEVPVMLMLVKFCLRTKGWFGEAEMVENVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU7</accession>
    <name>A0A1U9NGU7_9BACT</name>
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    </protein>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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            <begin position="7"/>
            <end position="27"/>
        </location>
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            <end position="66"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="94"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AQT66987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="27509" checksum="976FB6C33E2B9C08" modified="2017-06-07" version="1">MSKKWRIDIAGVSVIVCFVLVLVLLFSYARSSLDQGIYNHAVERALYFARIFIVLVPAGMLLLFLFSAVRKHFGMAVVYFIVTAFIVLQVPILVSRSFRMTYDVTSGYLMTEKLGRAVEVFCERPEQAGLPNEQWVAAFVKYAEAEEIWPSNLERCTFNDAIELTKLSSQPGDVFVFVFSPYDEENPNAQKPLLANVSMIEGWKDDYLLLYRNDGEIFRYLPDEDCYYEIDRSAWPLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV6</accession>
    <name>A0A1U9NGV6_9BACT</name>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">STSP2_00135</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956670" evidence="1">
        <location>
            <begin position="25"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4962" evidence="2">
        <location>
            <begin position="33"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="623" mass="69808" checksum="49F37E0D60F05911" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY6</accession>
    <name>A0A1U9NGY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT67193">
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        <property type="gene ID" value="STSP2_00336"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00336"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29985" checksum="F05AACEA5987D83F" modified="2017-06-07" version="1">MTPDKLKKYKAFFADHIARFNTDDPFIAANLKLKEVHTQKVCDETDYLTDALDLPETDRLIASAIALFHDISRFEQFYNHRTFADAKTFPHSIRSADILTETGILADLPADQQQIIDTAVRCHGQKSLPADLDERTLLFCRLIRDADKIDIYRVVLKNYREYHDCPEGFVMDIPEPHSHHASPHVIRAVLDKQPTDYASLRTVTDVKLLQLGWIFDLNFSASLARLHSRGQITELLSLLPDDPELKPVHNLITNHLKTHLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH67</accession>
    <name>A0A1U9NH67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">addA</name>
        <name evidence="12" type="ORF">STSP2_00414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00414"/>
    <dbReference type="EnsemblBacteria" id="AQT67271">
        <property type="protein sequence ID" value="AQT67271"/>
        <property type="gene ID" value="STSP2_00414"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00414"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDDEXK_1"/>
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    </dbReference>
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        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="5"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="500"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1229" mass="136283" checksum="60E1958480FA8010" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH89</accession>
    <name>A0A1U9NH89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66970">
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        <property type="gene ID" value="STSP2_00108"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00108"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013250995" evidence="2">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7553" checksum="02FE9CC66B07E580" modified="2017-06-07" version="1" precursor="true">MVRKLLAIVMIMVLGSFSITGCGGEEEPGDNIEETMEEAGEEMEEAGEVTEENLEDAVDEMEKEIEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG9</accession>
    <name>A0A1U9NHG9_9BACT</name>
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            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">STSP2_00094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66956">
        <property type="protein sequence ID" value="AQT66956"/>
        <property type="gene ID" value="STSP2_00094"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00094"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="84"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="154"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21719" checksum="E4EF1949399DA684" modified="2017-06-07" version="1">MTVVSAIVLLFLMMDPIGNIPVFVVTLRKVESNRHTYIIVREMLIALAVLVVFLFAGQYILDILQISQASVSIAGGIIIFLIAIKMIFSGSEKIFRGKIKGEPFVVPLAIPLIAGPAAMTMLMLMMAKNPQEWYKWLAALIVAWTIAGLCLVFAGKISRFMGERGLSAIERLMGMILTTVAVEMFIGGMRQLHMISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU2</accession>
    <name>A0A1U9NHU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67375">
        <property type="protein sequence ID" value="AQT67375"/>
        <property type="gene ID" value="STSP2_00519"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00519"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13445" checksum="8AFD06A8695D05EC" modified="2017-06-07" version="1">MVPWGGLENWLNVTVHCGENGASVRVSGDIIHSTELMTFLVGIERLSKTVKGQVEMACMEPYLSVVLKAGDCGHIEIQVDITPDPAKQKHSFIFEIDQSYLPKLITDCKKVLEEYPMIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI00</accession>
    <name>A0A1U9NI00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLUG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67397">
        <property type="protein sequence ID" value="AQT67397"/>
        <property type="gene ID" value="STSP2_00541"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00541"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012075417" evidence="1">
        <location>
            <begin position="23"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="817" mass="85713" checksum="2F390BA663A64068" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI87</accession>
    <name>A0A1U9NI87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxylamine oxidoreductase</fullName>
            <ecNumber evidence="3">1.7.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hao1</name>
        <name evidence="3" type="ORF">STSP2_00683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00683"/>
    <dbReference type="EnsemblBacteria" id="AQT67535">
        <property type="protein sequence ID" value="AQT67535"/>
        <property type="gene ID" value="STSP2_00683"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00683"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010701781" evidence="2">
        <location>
            <begin position="19"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="457" mass="51740" checksum="42A26DBF4C7CDA8C" modified="2017-06-07" version="1" precursor="true">MLSTKYIAIACCSIVAVAAVVGFAADDEEEKTYAPPDPKLKSFRIERDVSEDARECITCHADESRGIVADWAESRHAHANITCLDCHQAGAADEDISQSHFEHDKTAISPIVSPKDCSRCHPAEAAEYSKSKHANTLEIIWKFDPWLNAGMNNSIERSTGCEHCHGSVVKMQKDGTFDPETWPNVGVGRVNPDGSKGSCSSCHTRHLFSVSESRKPEACGQCHLGPDHPQIEIYEESKHGAIYHAQGDEWNWDSAPGTWTPGVDYRAPTCSTCHMSGVNGVATTHDVTERLAWESQAPLTIRPSEFKPFPSKTNWKTEREKMKNVCLACHSQTWTDGHFDRYDKAIENYNEVYYKPAKKMIDQLYAKKLLDDEKPLDQELEFDMYEFWHHEGRRARFGAAMMAPDYAWWHGFYELKQRYMEIERQYDHLMKTGEPAKVHEVPGATGSTEKPAFMRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA5</accession>
    <name>A0A1U9NIA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67478">
        <property type="protein sequence ID" value="AQT67478"/>
        <property type="gene ID" value="STSP2_00625"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00625"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5231" checksum="20E3F0D9EEA5FDBA" modified="2017-06-07" version="1">MRGDMRTMKRNVTELIRRVLLVGVGGFVLYFGSSRNTGEIDINGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII3</accession>
    <name>A0A1U9NII3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67597">
        <property type="protein sequence ID" value="AQT67597"/>
        <property type="gene ID" value="STSP2_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00745"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10145" checksum="933E39061D6A89C7" modified="2017-06-07" version="1">MCVGYFKIVNGGRSFDNFYLVERDGSACDVAEQIACLELAGLVPAPALDKERMLGRGLDDFVADRQNVNGINFTDQREKELIGFIFQCLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL5</accession>
    <name>A0A1U9NIL5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="2" type="ORF">STSP2_00813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00813"/>
    <dbReference type="EnsemblBacteria" id="AQT67665">
        <property type="protein sequence ID" value="AQT67665"/>
        <property type="gene ID" value="STSP2_00813"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00813"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15383" checksum="159C5E39C09327C9" modified="2017-06-07" version="1">MPTRRQEKINRIIKEVVADAIQNRLSDPRIEGIIISVTQTDVAPDLRTAEVYLSIMSEDEQVSNKAFKAIRGAAAHIRRLLSDKLTTRFTPELRFHRDIKIKGAIETLKVIEEAAKEFKEEDELNAPEDESTDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ3</accession>
    <name>A0A1U9NIQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67809">
        <property type="protein sequence ID" value="AQT67809"/>
        <property type="gene ID" value="STSP2_00959"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00959"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="38" mass="4156" checksum="3D629235835D579E" modified="2017-06-07" version="1">MTSFGKNGTYDGGGWDDQVLTFGVGEHGSIESFRRAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ4</accession>
    <name>A0A1U9NIQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ORF">STSP2_00815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00815"/>
    <dbReference type="EnsemblBacteria" id="AQT67667">
        <property type="protein sequence ID" value="AQT67667"/>
        <property type="gene ID" value="STSP2_00815"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00815"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NusA"/>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
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        <location>
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            <end position="170"/>
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        <location>
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            <end position="420"/>
        </location>
    </feature>
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            <begin position="397"/>
            <end position="413"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="420" mass="46383" checksum="FC7F57BCB7985684" modified="2017-06-07" version="1">MSQELIRIVENIARDKNIDKESIFADLEAALVSAARKAFSTSEETEIEVFIDRDNGNITAYKDGEKLDVKRFGRIAAQTAKQVMIQKLKADERESIFAEYVKRKGEAVNGSIARFEGGTMVIDLSNRVEAIMPKSEQIGGETHHVGERLRCMILDVREVSSQVRIILSRTHPDFIKRLFELEVPEVTEGIIEIKALAREAGYRTKIAVESHDDKVDAVGACVGVRGSRIRNIVDELSGEKIDIVRWSDSSQTLIANALKPAEVSEIAICFELGRATVVVTEDQLSLAIGKHGQNVRLAARLTSWDIDILTPEEYNAGVERLAECVTSIEGVDDSFVDQLLALGIISVLDLEEVGSEPLIEELGVDEDTAVKAVELAENVAKEIASEKKQAEDILEQEQARTEDEDEDEDTEPGLGIDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU3</accession>
    <name>A0A1U9NIU3_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase/protein folding accessory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="196" mass="22783" checksum="A75A6D28530A9722" modified="2017-06-07" version="1">MADGREGETLAEKVARVVAERVEVVEYDPRWQGMFEAEREHLRACLPGDLVGRIEHFGSTAVEGLAGKPIVDMLVEVFDLERVKREVAGVLEGQGYEYFWRPTWGDDGDPFYAWFIKRDGEGRRTHHIHMVEPGFEHWERLLFRDYLREHVEVAGEYAELKRRLEREHGGARVAYTEAKGEFIRRVTERARGYYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY4</accession>
    <name>A0A1U9NIY4_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Bifunctional enzyme CysN/CysC</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">cysNC</name>
        <name evidence="4" type="ORF">STSP2_01044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="gene ID" value="STSP2_01044"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="14"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="608" mass="68454" checksum="F6B740A91E363FD9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ2</accession>
    <name>A0A1U9NIZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01051"/>
    <dbReference type="EnsemblBacteria" id="AQT67899">
        <property type="protein sequence ID" value="AQT67899"/>
        <property type="gene ID" value="STSP2_01051"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01051"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="136"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24946" checksum="D5444BDA43CE6DF7" modified="2017-06-07" version="1">MAIYSLKNIASNRYNHLLVILIVVMTLSPFIEQGRIMPPMKLLTLLLLAAVIVCIRAAVDNPILFWISVILAVAAGALQYLALMPESTRITNILYFGSRIVDCCFLALTIVVLMHHMFTTKRFTSDMIVGGICIYLLIGILWAIFYDLSLKSSPEAISYSGDISFFYFSFVTITTLGYGDIVPASRGVMVLAQCEAVAGQLFIAIFIARLVALHTAYEMKRKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ03</accession>
    <name>A0A1U9NJ03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpmA</name>
        <name evidence="6" type="ORF">STSP2_00866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00866"/>
    <dbReference type="EnsemblBacteria" id="AQT67718">
        <property type="protein sequence ID" value="AQT67718"/>
        <property type="gene ID" value="STSP2_00866"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00866"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8420" checksum="7E8247D95F2B665F" modified="2017-06-07" version="1">MAHKKGQGSSRNGRDSNPQYRGIKLYGGQQAKAGSILVRQCGTKFQPGFNVGLGKDCTLFALKEGIVQFKGRKVHVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ20</accession>
    <name>A0A1U9NJ20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dpnA_1</name>
        <name evidence="6" type="ORF">STSP2_01081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01081"/>
    <dbReference type="REBASE" id="191335">
        <property type="entry name" value="M.PbaBD1ORF1081P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67929">
        <property type="protein sequence ID" value="AQT67929"/>
        <property type="gene ID" value="STSP2_01081"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01081"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015840">
        <property type="entry name" value="DNA_MeTrfase_ParB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036758">
        <property type="entry name" value="Aden_M_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ParB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="45852" checksum="57901BCF209A4513" modified="2017-06-07" version="1">MRITQRNTDSIRPYENNPRLNDEAVDAVAQSLKEFGFRQPIVVDEDGVIICGHTRFKAAQKLGLEKVPVHVAKDLSPEQVKAYRIADNRTGELSEWDWGQLKIELGDLQEAEFDLGMLAFDEEELNKLLDGDSEAVVEGLTDPDAVPEPPEEPITKRGDIWLLGDHRLMCGDSTSRVDVERLMDGCLADMVFSDPPYGVNYVGGTAEQMTIDNDNLSEADYISFMDAFFTRFRESIQETASLYICHASSWQLETELAMRQAGFEVRNQIIWAKNCGAFGFGRYKFQHEPIFYAHIKGESDKWYGDKTQTTLWQEKKPAANRLHPTMKPVEIVQRALVNSSKRSDLVLDLFMGSGTTLIAAETLGRRCVGMELDPAYCDVIVKRYEEFTGTKAKRSNEKTPAVAGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ80</accession>
    <name>A0A1U9NJ80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67847">
        <property type="protein sequence ID" value="AQT67847"/>
        <property type="gene ID" value="STSP2_00999"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00999"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188762" evidence="1">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="23088" checksum="DC6443CC3BF9E184" modified="2017-06-07" version="1" precursor="true">MGTLRTIVICGCVCVLMVSAGCLPEFENPLPESRAEEVSGELLGCWWRTLEDGTVQQVSFLPRAESKKFDAVFAFGIKSKDGAAVDMFEVYSVDLGESFLCAQKQVMGERRMEEEQPYFIMNYEVREDGRLEIRMLSLEKFKAAVEGGELAGTVKEKDESSRRPWDVVEVSASGEEVAEYIEKTPVSELVTDDEDLLLVFERTPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ93</accession>
    <name>A0A1U9NJ93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptide and tripeptide permease A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dtpA</name>
        <name evidence="3" type="ORF">STSP2_01145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01145"/>
    <dbReference type="EnsemblBacteria" id="AQT67991">
        <property type="protein sequence ID" value="AQT67991"/>
        <property type="gene ID" value="STSP2_01145"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01145"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="436" mass="47253" checksum="EB3F4C89927F0165" modified="2017-06-07" version="1">MGDSAVENAGAGRMPGAVPHILMNKTGERFAFYGIRTILVVYMTRYLLDASGEAAPMGEEQAKSVFHYFTAAAYFLPVVGAVLSDALLGMFRTIVVFSLFYSAGALLLAVDGTRTGLYAAMVLLAVGSGVIKPCLSANVGEQFDKSNEHLMSRVYGWFYFAINVGAIGSMALTPWLLERFGPGLAFGVPAACMIVAMAAIWVGRGKMKRGEGAGMDFVRQILRWDTVRGVGHVFVIFLFVAVFWALFDQTSSAWILQAEKMDRRWLGVEFLPSQMPAVNAGLVMAGIPLFNYVVYPAMGKIFKLTALRKMGVGFFVTAGAFAISAMIERAIGAGAEVSIGWQVLAYVVLTAGEIMVSITAMEFSYTQAPREMKSFMMSIYFLSISLGNVFTAGVNTFIQNADGTSKLAGAEYYWFFAAVMAVAAVVFVPVARAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF2</accession>
    <name>A0A1U9NJF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argE</name>
        <name evidence="3" type="ORF">STSP2_00794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00794"/>
    <dbReference type="EnsemblBacteria" id="AQT67646">
        <property type="protein sequence ID" value="AQT67646"/>
        <property type="gene ID" value="STSP2_00794"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00794"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="169"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="39980" checksum="FAC272F18B5F7BA1" modified="2017-06-07" version="1">MSEGKVQIQADRLKELMRDMVDIYSPSGKEGEIGEYLAGYLLDKGLPVTLREVSEGRRNVEVVFSDKRPEIAFIGHIDTVPAYDIENYEFDEEDGLIYGLGTADMKGGCAAMVEAFVAAVEAGMKPERAGLFLVVGEEETSDGTAALLEARSFPWAIIGEPTNLVPCLAHYGYMEMLVRVFGTRRHAATAGREYNAIFSTLRMLLRLGGIIEAEHPEAILNIRDIHSSEAGFAVPGSCEAWVDLHIPPAANPKQFASELEKIVRESLTGGSVTDYEIDFPLLAKGSRASGAGLVPEVLEKAYAGEGMEWHPGAFKSHSDANLLCEAQCETVIIGPGQLEKAHTRDESISFEQVEKAARIYGGVLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ9</accession>
    <name>A0A1U9NJJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem I assembly protein Ycf3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01257"/>
    <dbReference type="EnsemblBacteria" id="AQT68102">
        <property type="protein sequence ID" value="AQT68102"/>
        <property type="gene ID" value="STSP2_01257"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01257"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="790" mass="88934" checksum="9FEB8EC8FE62E1D4" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM0</accession>
    <name>A0A1U9NJM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KWG Leptospira</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01277"/>
    <dbReference type="EnsemblBacteria" id="AQT68122">
        <property type="protein sequence ID" value="AQT68122"/>
        <property type="gene ID" value="STSP2_01277"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01277"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010699081" evidence="1">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="48441" checksum="97A291064A0189A5" modified="2017-06-07" version="1">MRKFSLTQLMLMLLGIGQTLFGATSNCDYKFVLETYEGKFGVLDSAEGVIIPAKYDLIYFGVPFVGNTVAWTPESMIAFDAEGEGIATLAGSWEKWSSHYIDERFLFAFDGQNGQLFDYTRQEKVFECSDALRRDYNSADMLELIAVRVDDKWGFIKPGGSIAIEPKYDAVENFSNGYAPAKLSGKWGIIDLQAETVLDFDFDRIERIYWPESRFAVVQKNGKYGLYEKSEKLFRDKWFEFIRVFDNYIFVSTESEGGQVLDLSGKEIMSGFDFFWPDPDVGFIVSKVEEESMYHVDFTGTELYKERFKLVAPFTNGLAPAKPLGEKLRGYIDKNGKFVIEQRFLSSGDFNGSLAFVRELRDDKVYHGYINNQGDMVIQIAVTDLDYGLRPQMRSFIGGLAYVQLEDRKGYIDTKGNWVWSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ7</accession>
    <name>A0A1U9NJQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67974">
        <property type="protein sequence ID" value="AQT67974"/>
        <property type="gene ID" value="STSP2_01128"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01128"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14652" checksum="753342811BAD31B2" modified="2017-06-07" version="1">MDKQKIEQAVHFAANVGPVCIATVDNQGMPHVDAAGQIDLGAEDNVYLTRCFGPQTLMDLKQNDHIAVLIWNEQSQDGYQLIGQCSKIEEISEHGETQEMFDAEQAYYKGEQRLTVHVDKVSELKQKSSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR9</accession>
    <name>A0A1U9NJR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01212"/>
    <dbReference type="EnsemblBacteria" id="AQT68057">
        <property type="protein sequence ID" value="AQT68057"/>
        <property type="gene ID" value="STSP2_01212"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01212"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="195" mass="22665" checksum="C1949A6A353FF3F3" modified="2017-06-07" version="1">MTSENKKLNWINGDEVPESSSGEKDATSCYFRLLTQNYRKIYSYILTLVPSRSDADDIMQETATVMWTKFSEFKEGTNFAGWGIRIAYFQVLYFYRKNKARPVQFPADILEKMGAAAEKKSGQNEELLKTLRECVERLDERDRKLLQMRYEQGMAPKNLAEFLSKPVKGIYRSMSRIHNTLVMCIRRTLAAEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV8</accession>
    <name>A0A1U9NJV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01260"/>
    <dbReference type="EnsemblBacteria" id="AQT68105">
        <property type="protein sequence ID" value="AQT68105"/>
        <property type="gene ID" value="STSP2_01260"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01260"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911329" evidence="1">
        <location>
            <begin position="24"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="196"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="701" mass="77676" checksum="4DDC4AF97BD0B033" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY1</accession>
    <name>A0A1U9NJY1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable pectate lyase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01280"/>
    <dbReference type="EnsemblBacteria" id="AQT68125">
        <property type="protein sequence ID" value="AQT68125"/>
        <property type="gene ID" value="STSP2_01280"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01280"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="705"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1077" mass="114790" checksum="A4E91A297BA6F9F1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK00</accession>
    <name>A0A1U9NK00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wapA_8</name>
        <name evidence="3" type="ORF">STSP2_01408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68252">
        <property type="protein sequence ID" value="AQT68252"/>
        <property type="gene ID" value="STSP2_01408"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01408"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798474" evidence="2">
        <location>
            <begin position="28"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="2590" mass="292654" checksum="2D876EFE8528EE49" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK50</accession>
    <name>A0A1U9NK50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-8-phosphooctulonate synthase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kdsA</name>
        <name evidence="8" type="ORF">STSP2_01460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01460"/>
    <dbReference type="EnsemblBacteria" id="AQT68302">
        <property type="protein sequence ID" value="AQT68302"/>
        <property type="gene ID" value="STSP2_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01460"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29268" checksum="8BABEC3997732E7C" modified="2017-06-07" version="1">MFRIGDFKVGLESDLFLMAGPCVLEDMDTCRAIAEELVKVRENTGIGVIYKGSFDKANRSSIDSFRGPGLEKGMEVLAAIRDEFGFAVMTDVHEPWQAEQIAKTVDCMQVPAFLCRQTDLLMACAKTGKPTAVKKGQFVSPGEMKNVVGKLRASGLDDIMLTERGTFFGYNRLVNDMTAIEQMKQLGAPVIFDATHSTQQPGGLGSASAGRREMAPLLARSAVAAGANGLFLEVHTDPENAKCDAACIMPVGWVEKLIRECQAIAEVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK57</accession>
    <name>A0A1U9NK57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68312">
        <property type="protein sequence ID" value="AQT68312"/>
        <property type="gene ID" value="STSP2_01471"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01471"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010260">
        <property type="entry name" value="AlpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05930">
        <property type="entry name" value="Phage_AlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10447" checksum="2EB41A582CA8BEED" modified="2017-06-07" version="1">MNSPKNMIMEASRNCQNKREGEAEPQIRLITAEQFGHILGLSKRQIFRLNATGRVPKPLKIGGAVRWNKGEIHAWLQKGAPDRLTWEAIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK78</accession>
    <name>A0A1U9NK78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent zinc metalloprotease FtsH 3</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ftsH3</name>
        <name evidence="2" type="ORF">STSP2_01299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01299"/>
    <dbReference type="EnsemblBacteria" id="AQT68144">
        <property type="protein sequence ID" value="AQT68144"/>
        <property type="gene ID" value="STSP2_01299"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="267"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="498" mass="55753" checksum="A7E078632D6385AB" modified="2017-06-07" version="1">MSDVERLKQLIAAGYPCISIVTHEEDQALETVRAAVMELQRGLLIWSIGYGVREGLLADSPAEPETDKPETGLCHFAMAKNNPVRVALDLNQHLTGAGSELTLRVLRDTIHRIEKNDGTLILINPNDDLPPVIKSHCTPFELALPTEDQLEQLIKDTLRECHRKTPIEIGITRRGMNAIIKNLRGLTRRQARRLVCDCVADDRRFDDEDVNRVLAGKRKVLQSDGLLEYVETPLDLDEIGGMKNLKRWLKHRKNAFKDEASNFGLKPPRGVLMLGVQGAGKSLCAKAIATAWQQPLLRMDPGSLFNKYIGESEQNLRKALNQTEMMSPVILWIDEIEKAFASASGQSNDGGLSRRMFGSLLTWMQEHEHPVFLVATANDIESLPPELLRKGRFDEIFFVGLPKQAARKAIIKIHLKKRNRNPEDFDMDKLIELSDGYSGAEIEQAVVSSLHDAYENNGKLTTEMIATALKNSPPLSVTMAEKINDLYAWAEDRTVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK97</accession>
    <name>A0A1U9NK97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01513"/>
    <dbReference type="EnsemblBacteria" id="AQT68353">
        <property type="protein sequence ID" value="AQT68353"/>
        <property type="gene ID" value="STSP2_01513"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01513"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28010" checksum="D89CB9AF6B244451" modified="2017-06-07" version="1">MDFVSLIIIGLVTGVFGGLLGIGGSMIMIPALAFVFGENQHLYQAAAMITNFFVSTSSLIAHRKAEAFVPGVLKWMIPAALAGIVGGVAMSNMDLFAGENSYLLARVFGVFLIYVVVYNLFRFKRGGFKDNTKTADLAAPDTPTYLSLVIGFVTGTAAGLLGIGAGGVCTPLQQVFAKMPLKRAMSNSAAIITSMAWLGAAYKNLTLGQHGIDIAESLKIAGIVIPTAILGGFWGGHLMHAIPRSWVRAAFILIAAVGAVKMLTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE3</accession>
    <name>A0A1U9NKE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF_1</name>
        <name evidence="7" type="ORF">STSP2_01563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01563"/>
    <dbReference type="EnsemblBacteria" id="AQT68403">
        <property type="protein sequence ID" value="AQT68403"/>
        <property type="gene ID" value="STSP2_01563"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01563"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="39"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="38674" checksum="C7BD849CBBBBD00D" modified="2017-06-07" version="1">MEHTDNLNIVQFKPLITPDQLKAQHPVTEQTLKSVAQSRHAVQRILRGEDKRRMVITGPCSLHDEKATIDYAQRLKKLQQDCADEILIIMRAYFEKPRTTIGWKGMLYDPHLDGSYDIEFGITQSRKLLCDIAEIGLPTATEFLDPIVPQYIADLITWAAIGARTTESQIHRQMASGLSMPIGFKNATDGNLGVAMDAIKAAMNPHSFLGIDRNGKVISAETRGNLYGHLVMRGGKDEPNFASQYVAFAEVLLQKLEIPNGIVIDCSHSNSYKDFKRQRNALEDIADQIRNGNKTIAGVMLESFVNEGKQSIDAPQLNYGVSLTDSCIGWQETEQLIRHLAGAVKAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG9</accession>
    <name>A0A1U9NKG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein BirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="2" type="ORF">STSP2_01559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01559"/>
    <dbReference type="EnsemblBacteria" id="AQT68399">
        <property type="protein sequence ID" value="AQT68399"/>
        <property type="gene ID" value="STSP2_01559"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01559"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28736" checksum="4D7E73D8009B57B8" modified="2017-06-07" version="1">MGTDAGWVDRLDVDRIEEAASGCVIGRRVVVYQSTRSTNDIAWEYAKGAESDGLVVFAEEQSGGRGRRGNKWLSSAGQSLLCSVIVSGVSAGAELLTLASAVATAEAIREYAGVSARIKWPNDVMVGGKKICGILVESRAIAGRKVFVVGIGINCHQGEDFFGSEELRMPGTSVDLAMGEVCDRNELAGVLLRKLDVWVGKMQADEKAVIDGWGRLSSQLGEYVTVEHNNRRYSGICAGVDPVEGLILRLDGGAVRMFEAGQTTIVKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN0</accession>
    <name>A0A1U9NKN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01231"/>
    <dbReference type="EnsemblBacteria" id="AQT68076">
        <property type="protein sequence ID" value="AQT68076"/>
        <property type="gene ID" value="STSP2_01231"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01231"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572547" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="81"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26464" checksum="9611971C3762B08E" modified="2017-06-07" version="1" precursor="true">MKKFVVSMAVVIVACAGAQAGIVEHLTFDIDGTAATGTDAVLVGDAAVTTGGMGISGEALQLDGDGDFATTPGFKGIAGADARTVSLWVKTAVNQADGTFFLGWGDTGFGSRVRYDLGLQKGTSDQLRNELNAGAITSNTGTTITDDAWHHISLTFDGTTTTFYVDGQTYGTSTTSVNTTTTEDLVIGTGIRPATEFNENARWTNGLIDDVQIYDEALTGDQVATLYANPGTVVPEPATLAILGIGALALGRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP8</accession>
    <name>A0A1U9NKP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine monophosphate-protein transferase SoFic</fullName>
            <ecNumber evidence="5">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01467"/>
    <dbReference type="EnsemblBacteria" id="AQT68308">
        <property type="protein sequence ID" value="AQT68308"/>
        <property type="gene ID" value="STSP2_01467"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01467"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="129"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="42310" checksum="811E6209E255CA30" modified="2017-06-07" version="1">MAFKRSQPYNDLPLLPPKADIESKTILKQCILARSELAALEQAGELLPNKSVLIHTIPLLEAQLSSEIENIVTTTDKLFQLASGSKQSADSATREALRYRQALYQGCKAIEKKPLCTSIAVEICSTIRDTAVDIRKVPGTTLSNPSTGQIIYTPPAGEQIIREKLTNWERFINEETSLDPLIRMAVMHYQFEAIHPFTDGNGRTGRILNALLLVQEQLLKTPILYLSRHFIRTKTQYYSLLRDVTENGNWHGWIIYVLQGIEETSKWTTRKIKAAQQLIEHTCDYVKQKLPRTYSRELVETVFEQPYCRIPNLIEKGIAARQTASVYLKRLTEIGLLEENQVGREKVYVHTKFLALLTQDENTFEPYTNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW3</accession>
    <name>A0A1U9NKW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgB_1</name>
        <name evidence="9" type="synonym">glgB</name>
        <name evidence="12" type="ORF">STSP2_01619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01619"/>
    <dbReference type="EnsemblBacteria" id="AQT68455">
        <property type="protein sequence ID" value="AQT68455"/>
        <property type="gene ID" value="STSP2_01619"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01619"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="162"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="641" mass="74181" checksum="FD68571539E776AA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ0</accession>
    <name>A0A1U9NKZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arnB</name>
        <name evidence="4" type="ORF">STSP2_01769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.87" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01769"/>
    <dbReference type="EnsemblBacteria" id="AQT68601">
        <property type="protein sequence ID" value="AQT68601"/>
        <property type="gene ID" value="STSP2_01769"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01769"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099620">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose aminotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="41073" checksum="8D072DFA9A1461DA" modified="2017-06-07" version="1">MRVHLSRPDITQAEIDAVTEVLKSPNLSLGPKLGEFEQAFCDYIGRKHAVAVNSGTSGLFLCMQSLGIGPGDEVITTPFTFIASVTSIMMTGAKPVFVDIDPVSLNMDSSRIEAAINEKTKAILPVVVFGNPAGLDEVSEIADRHNLAVIEDSCEALGSELNGRKVGTFGTMSLFAFYPNKQITTGEGGMILTDDDELANMCVSLRNQGRGRGGGWLAHERLGYNYRLSDINCALGIVQLSRIGEFVEKRKQVAAMYQELLADEKRLIVPKAPAGCEMSWFVFVVRIADENITIEQRNAVLQAMLDRGVQVSNYFPPVYLQPFIAQEYGLKEGDFPITDAVCKSTIALPFHNNLTQEEVETVCKELKASLDDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL07</accession>
    <name>A0A1U9NL07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxaC</name>
        <name evidence="7" type="ORF">STSP2_01791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01791"/>
    <dbReference type="EnsemblBacteria" id="AQT68623">
        <property type="protein sequence ID" value="AQT68623"/>
        <property type="gene ID" value="STSP2_01791"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01791"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="53798" checksum="6981777723886BA1" modified="2017-06-07" version="1">MSDKFLTEEFLLFSEPARQLYHEFAAKMPIYDYHCHLPAAAIAEDINFDNLAQAWLGGDHYKWRAMRTNGAEERYCTGDASDREKFQKWAETVPYCIRNPLYHWTHMELKKPFGIEGQLLGPDTADAIYEQCSEMLRSPGFSVRGILKKMNVELVCTTEDPLDSLEHHQAIKESGCEVAVHTAWRPDKAMGVDDLQQLNAWIDRLGQLTDTDITGYDDYLRALDVRHQHFHDNGCRLSDHGLEVPLAAEYTNSQVKLIFDKIRTKQSLNDCEKEQFQTALLVELTEMNFNRGWVQQLHIGPIRNNSSRLFKQCGPDAGFDSMGDAPIAKPLAALLDRLDTDGKLAKTIIYNINPKDNETVATMIGNFQDGSVPGKMQYGSGWWFLDQIDGMTDQMRALSNMGLLSRFIGMTTDSRSFLSFPRHEYFRRVLCNLIGDDIDKGLLPADMEWMGKIVEDICFNNANDYFGMELNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL19</accession>
    <name>A0A1U9NL19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EIIABC-Fru</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fruA_2</name>
        <name evidence="2" type="ORF">STSP2_01801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01801"/>
    <dbReference type="EnsemblBacteria" id="AQT68633">
        <property type="protein sequence ID" value="AQT68633"/>
        <property type="gene ID" value="STSP2_01801"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01801"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16522" checksum="1756B978A53D9D78" modified="2017-06-07" version="1">MILTQILQPTCIKAPLEATDKESAITELVDVLSENGLIQNRDAVLEAVLMREETRSTGIGSGIAIPHGKCNGVSELVMSIGIAKEGIDFDSIDGKPATVVCLLASPVDRTGPHIQALARISRLMLDEEFKSRLESSDTPEEVYELICSKENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL24</accession>
    <name>A0A1U9NL24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate-acceptor oxidoreductase subunit OorD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01588"/>
    <dbReference type="EnsemblBacteria" id="AQT68428">
        <property type="protein sequence ID" value="AQT68428"/>
        <property type="gene ID" value="STSP2_01588"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01588"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7289" checksum="D88EE46BB7A18798" modified="2017-06-07" version="1">MADINIDKKKCKGCCLCVSCCPRGNIEMSDEPNEAGAYYACIIDEKECTGCAICCQMCPDVAIEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL71</accession>
    <name>A0A1U9NL71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_2</name>
        <name evidence="8" type="ORF">STSP2_01853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01853"/>
    <dbReference type="EnsemblBacteria" id="AQT68683">
        <property type="protein sequence ID" value="AQT68683"/>
        <property type="gene ID" value="STSP2_01853"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01853"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010704492" evidence="7">
        <location>
            <begin position="23"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="890" mass="97247" checksum="44BABDE6C56B65C8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL95</accession>
    <name>A0A1U9NL95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bfce</name>
        <name evidence="3" type="ORF">STSP2_01849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.11" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01849"/>
    <dbReference type="EnsemblBacteria" id="AQT68679">
        <property type="protein sequence ID" value="AQT68679"/>
        <property type="gene ID" value="STSP2_01849"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01849"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047736">
        <property type="term" value="F:cellobiose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00249">
        <property type="entry name" value="AGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034116">
        <property type="entry name" value="AGE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="394" mass="45761" checksum="96E36E80074BF67D" modified="2017-06-07" version="1">MSWDKAAKYAEVYRKELFESVMPFWDEYSVDSEFGGYFTCLNREGEVFDTDKFVWLQCRQVWTYAMLYNRCEKREEWLEVANNGADFLALHGMDGEGNWYFALNREGMPLVQPYNIFSDCFAAMAFAQYGLACGSEKAIDIASKTYRNILRRKDRPKGKYTKAVDGTRDMKGMALPMILANLTLELEEVLSEDEVESTLDMCIDEVMGLFLDERKGILYENVGPDGSHVDCFDGRLINPGHGIESMWFMMDVAKRRGDKELIERAVQVVLNTLEYGWDEEYGGIFYFMDAEGRPPQQLEWDQKLWWVHLEALVGLIKGYNLTGRQECLDWFERVHEYAFGGFSDPKFGEWFGYLNRRGEVLMPLKGGKWKGCFHVPRGLYLCWREFENLGGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD3</accession>
    <name>A0A1U9NLD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative phospholipid ABC transporter permease protein MlaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mlaE</name>
        <name evidence="8" type="ORF">STSP2_01803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01803"/>
    <dbReference type="EnsemblBacteria" id="AQT68635">
        <property type="protein sequence ID" value="AQT68635"/>
        <property type="gene ID" value="STSP2_01803"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01803"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28860" checksum="37F3B4CC93DA71CC" modified="2017-06-07" version="1">MLEALGAATINWIQHLGRFARFLGRTTSTSAVSITQPKTWPLVTNQMYTIGVRSVPVVMITGAFVGMILAIQAYDQLAGMKLEERLGQLLNISVVKELGPVLAAVMLAGRVGGALTAELGTMNVTEQIAAVRSMGTDPVKYLVAPRVLACLLLTPFLIIYADLLGILGGYFVSVIQLKINSGAYWNYSAQGVQMWDIATGITKGFFFGAAISAISCYKGFHCRQGAQGVGQACTEAFVGSFIAILAINFVFAVIAKAIYNTFWPMPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI2</accession>
    <name>A0A1U9NLI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcpC_3</name>
        <name evidence="2" type="ORF">STSP2_01966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01966"/>
    <dbReference type="EnsemblBacteria" id="AQT68793">
        <property type="protein sequence ID" value="AQT68793"/>
        <property type="gene ID" value="STSP2_01966"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01966"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="531" mass="59098" checksum="8629A9B52E56C7CA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK9</accession>
    <name>A0A1U9NLK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68799">
        <property type="protein sequence ID" value="AQT68799"/>
        <property type="gene ID" value="STSP2_01972"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01972"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234083" evidence="2">
        <location>
            <begin position="42"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="486" mass="54857" checksum="8F937EBE80B205C6" modified="2017-06-07" version="1" precursor="true">MFTGGKDNAMKNSADTQMHKTRTILFALLALAAMLTTNMQAAEQPVRIEPRSGQTNLTGEQLAMWNDPDFQKQFTQSYIAETEIEPRVTVDERDDMQEVLELISDDKLDGAVELLRKNRNEAASAVFDFTLANIYFQQEKLDQAAEVYNVAVDKYPKFRRAWKNLGLIYVRQSSFAPAVECLTRVISLGGGDATSYGLLGFAYSSLDKSIPAESAYRMAILLDSETLDWKMGLARSFFKQERYGEAVALLGQLIKDQPENKDLWLLQANAYVGMGKPLESAEILEFVDHLGQSTAESLFMLGDIYINEQLYEIAADSYMRAMDKNPDQNVERSLRCAKILAARAAYDQTQLLVSNIESTYENQLSDEQKKNLLKIRSRLAVAKGSADEEAKVLEKIVELDPLDGEALILLGQHYGRKGDTEQAIFYFERAAGIDEYEADAKIRHAQLLVRNGHYAKALPLLRSAQRIEPRENVQEYLEQVERVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM8</accession>
    <name>A0A1U9NLM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino-acid acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argA</name>
        <name evidence="4" type="ORF">STSP2_02017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02017"/>
    <dbReference type="EnsemblBacteria" id="AQT68841">
        <property type="protein sequence ID" value="AQT68841"/>
        <property type="gene ID" value="STSP2_02017"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02017"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20322" checksum="CEFA0EEBC95BBD8E" modified="2017-06-07" version="1">MAAYFWNLAGFDGCLLFFAVLIVFAICYSQLMQIRKARSSDARAINELIASHAELERMLFRSMADIYDHLQTFSVAEEDGRVVGCCALSVVWEGLCEVKSLAVDNSCMGKGLGRKLVEAQIEKASELGLEKIFTLTLEPGFFEKLGFERVDRMSLPMKVWSDCAKCSKQDHCDETALARAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP2</accession>
    <name>A0A1U9NLP2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hflC</name>
        <name evidence="4" type="ORF">STSP2_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02029"/>
    <dbReference type="EnsemblBacteria" id="AQT68853">
        <property type="protein sequence ID" value="AQT68853"/>
        <property type="gene ID" value="STSP2_02029"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02029"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="35506" checksum="84D59AEB5BFF7145" modified="2017-06-07" version="1">MKNLWIIVLVFLIVGVLGLYWFSFQVRETETVVVTRFGEPVRTISEPDWYMKWPVPINKVHRFDSRNHFFELDLEQTNTRNGEPILVTSYVVWRISDPQKFLESVENEREAETQLESLVRDAQNKVVGQYSFSEFVNSDPEKIKFNEIEQEMLARLDQAETDYGIDITKAGIKRLGVPESVTQKVFDRIRADRERRIAKIIADGEAAAGKIRADAESKRTELLAIVEAEAKAIKGRGDAEAAKYYKMLEEDPQLAMFLRDLEALKKILKQKSTIVLGADSDPLKLLKGLPELDLPEAEEQSEDAVAADGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY1</accession>
    <name>A0A1U9NLY1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmB</name>
        <name evidence="6" type="ORF">STSP2_02118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02118"/>
    <dbReference type="EnsemblBacteria" id="AQT68941">
        <property type="protein sequence ID" value="AQT68941"/>
        <property type="gene ID" value="STSP2_02118"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02118"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9210" checksum="80B63055EB947796" modified="2017-06-07" version="1">MARVCQYTGKRTKVGNSVSRRGKAKRHGGVGIKTTGISRRKFKPNVQKVKAVVDGKVCRVKASAKAIRMGLVTKPPKRNYKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM04</accession>
    <name>A0A1U9NM04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA_2</name>
        <name evidence="6" type="ORF">STSP2_02160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02160"/>
    <dbReference type="EnsemblBacteria" id="AQT68982">
        <property type="protein sequence ID" value="AQT68982"/>
        <property type="gene ID" value="STSP2_02160"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02160"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11771" checksum="AEAAF1D9148CAFB5" modified="2017-06-07" version="1">MAGNVVELTDATFDDTVTGSDVPVLVDFWAPWCGPCKMIAPVIDELADEYAGKAKVCKVNTDEHREAAVEYAINAIPTIILFNNGQVAKKWVGMTTKKDITAEIDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM31</accession>
    <name>A0A1U9NM31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68794">
        <property type="protein sequence ID" value="AQT68794"/>
        <property type="gene ID" value="STSP2_01967"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01967"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016866">
        <property type="entry name" value="UCP028069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11932">
        <property type="entry name" value="DUF3450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="276" mass="31370" checksum="844493A7915126A3" modified="2017-06-07" version="1">MKKLLNVKLTYLRDSWKRSASLKWAVILLTPFLLLAGSRSLQAADEVGPQQARLLIEKWVETERLISEEKQKFRLASEMLEERISLVKNEIKSLKDKISETEDSIAEADKKRKEMVEENEKLKETSTFMTDTATDLEGRCKDLIKRLPNPIKDRIRPLSQRLPEDPAKTDLSLSKRFENVIGILNEVDKFNREVTAVSEIRDLTDGSSIEVSTLYLGLGQAWYTNADGDIAGISVPAEDGWQWQQDNTIALNVKEAIAVLNNEKVAEFIELPVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM55</accession>
    <name>A0A1U9NM55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trpB_1</name>
        <name evidence="11" type="synonym">trpB</name>
        <name evidence="13" type="ORF">STSP2_01754</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01754"/>
    <dbReference type="EnsemblBacteria" id="AQT68586">
        <property type="protein sequence ID" value="AQT68586"/>
        <property type="gene ID" value="STSP2_01754"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01754"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="391" mass="42240" checksum="95A83DF7117D724B" modified="2017-06-07" version="1">MKHKGKFGEFGGYYVPELLIPPLEDIEQAFYQYKDDKDFVAELSNLYADYAGRPTPLYFAERFSEYVGYNVYVKREDLLHGGAHKVNNTLGQCLLAKYMGKKKIIAETGAGQHGLATAMTGALLGMETKIFMGKIDVERQSVNVHKMRLCGAEVIPVAGGTGTLKDAINEALRYWTANVEDTFYVFGSVCGPHPFPTVVKHFQSPIGTEARAQCMEKLGKLPDMVTACVGGGSNSIGLFSAFVADESVRIVGVEPAGKGLATDQHAASLAAGRVGVFHGSKSYLLQDDEGQVHETECVSAGLDYPAVGPEHCHLKDSGRAEYVTVTDEQVLDAFETFTRTEGILPALESSHAIAHLIALKGKLAAETNVVLNLSGRGDKDVGIVETYRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM58</accession>
    <name>A0A1U9NM58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pnp</name>
        <name evidence="8" type="ORF">STSP2_02092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02092"/>
    <dbReference type="EnsemblBacteria" id="AQT68915">
        <property type="protein sequence ID" value="AQT68915"/>
        <property type="gene ID" value="STSP2_02092"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02092"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="622"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="702" mass="76694" checksum="94D4B65DF87D0603" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC9</accession>
    <name>A0A1U9NMC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_7</name>
        <name evidence="2" type="ORF">STSP2_02071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68894">
        <property type="protein sequence ID" value="AQT68894"/>
        <property type="gene ID" value="STSP2_02071"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02071"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14927" checksum="835ACC4FECC89F5A" modified="2017-06-07" version="1" precursor="true">MRARKGFTLVEILIVVVILGILAAIVIPQFSQASSDAKLSSLRSNLQTMRSQIALYKVQNSDNLPPADTLANFEGAMCPEYLQSVPNNPFTGGNTITQGDNTGLAGAPGDGSSDWYLNTTEGIVYANDTGTLDDGTAHSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ1</accession>
    <name>A0A1U9NMJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">accA</name>
        <name evidence="13" type="ORF">STSP2_02195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02195"/>
    <dbReference type="EnsemblBacteria" id="AQT69017">
        <property type="protein sequence ID" value="AQT69017"/>
        <property type="gene ID" value="STSP2_02195"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02195"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="40336" checksum="677DC4ADB56738EE" modified="2017-06-07" version="1">MAGQNDNNTVNQYLPFEETVAQLDRQVVELKEQAQTKGLDFSAEIRQLQKAQTKELKRVYSSLNPWQTVQVARHPQRPLFTDYLDHMVKDVRELHGDRLFGDDRAIVTALGQIGHEKVMIVGQNKGRETKEKIECNFGCPNPEGYRKALLKMKFAEKYGLPIVTFIDTPGAYPGIGAEERGQAQAIALNLMEMSRLKVPIICIVIGEGGSGGALGIGVGDQIAILEYAYYSVISPEGCAAILWRDGSKANEAADALKLTSTDLKKLNLVDEVIKEPLGGAHRNVHDTIYNVEQYILKALRDCKRQKIDNLLDARYEKLRKLGNAFQTVAQSKSQEKELPDNLSVKKQLEQATKAQKQRMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ6</accession>
    <name>A0A1U9NMJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69133">
        <property type="protein sequence ID" value="AQT69133"/>
        <property type="gene ID" value="STSP2_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02320"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504938" evidence="1">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="46922" checksum="8D28BC2B7EF54D2C" modified="2017-06-07" version="1" precursor="true">MKKVMLLLIAGLAVVVPAQANLLVNGDFEDGPIGEINVVGLPGWEFWAGQYTLYHHSDTERTLDEKACAIFWTDAGVGQYFDAEAGVEYTLGVSMLSSTSTDTYNGQPANMYGKDDVLSVEWYDGSGVIIGQTIEVDRFEGGVDPDDVWTLISGNVVAPAGAAQGMLVISQVVTDASNNGGGAHFDNAFVVKAGQATSPSPADGATVSTELDTISWQNAAETATVDVWFGTVGEPNSLIADDIAAETLSLSAPPIGSAITLASGEVYEWKVDSKDSSGNVVEGTWWTFNTGNMAPIADAGEDQYIWLENGQAQVILTGSVQDDGMTEGYTVSWSLDAAESDPATTVVIDPNDVETTTVTIDGEGWYTLKFTADDGMYTDEDFVAIGVYDSPCTAAKEDPADPYNNYPNGLHGDLDGDCDTDLDDFAILAATWLDCMSPKMGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM0</accession>
    <name>A0A1U9NMM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylE_3</name>
        <name evidence="8" type="ORF">STSP2_02232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69047">
        <property type="protein sequence ID" value="AQT69047"/>
        <property type="gene ID" value="STSP2_02232"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02232"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="491" mass="53343" checksum="10C1C3F198EFBEEA" modified="2017-06-07" version="1">MKVVKEKTDGEYNLRYLLGISLVSAMGGLLFGYDLVVIGGAKEFYELVYNLSSPAIKGWAVSSCIVGCIIGALCVGKPADVFGRKKLLIVSAAMFFVSAIGSGYAPTFTQFVLYRLLGGIGMGFASTLSPMYIAEVSPASLRGRFVSLNQMTIVIGILLAQLVNYLILQSHPVPEGVEGAALLNTWNGQTGWRWMFAAEGIPALLFFALMFTVPNSPRWLCRAGRTEKAVTVMEKVGGAGYAGNSLASILETFDEKSRRHEVRELLKPRMRKILLIGIVLAVFQQWCGINVVFNYAHDIFKAAGYNVSGVLFNLVIVGITNFAFTIVAMFTVDKIGRKSLLLWGSAGLAISFGVVGLFFHLNVQGILVLLMVLAALACFAATLGPVVWVVISEIFPNRIRGLATSIAVLSLWIGNFVLSYTFPIIQDAYSIAATFWIYAVVCVLGVVFIRIYIPETKGKTLEQIEANLLDENLKETYGESQGTGKKVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP0</accession>
    <name>A0A1U9NMP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02252"/>
    <dbReference type="EnsemblBacteria" id="AQT69067">
        <property type="protein sequence ID" value="AQT69067"/>
        <property type="gene ID" value="STSP2_02252"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02252"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="391" mass="42579" checksum="9746D9B5A63A1AA1" modified="2017-06-07" version="1">MKIAYLDCFAGAAGDMFTSSMLHAGADKESLIDKLQSLKLPDLQIQITEVMRSGISCCHFKPTASEEQPHRHLPDIVNIIEQSDISERAKKDAVSIFEILADAEAKVHNKTRETIHFHEVGAVDSIVDIISACVCVDLLGIEKVICSPVTVGFGMTKCAHGQMPVPAPATAEILQKASVPTRPGPVEAEMLTPTGAAIIAHFVTEFGPPPQMAIENIGYGAGTADHEKLPNALRIMIGCIDQPKETDTDTICLLETNIDDLTGEQIGDICEVLLDNGALDVFTTPIYMKKSRPAVMLSVICEPDCEQNLTAIMFSHGITLGIRRQALQRSILKRRFVEVDTEFGTIPVKIAEFGGCVVTAKPEFDKCRQAADKFKVTTKQVEIAVMRDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ9</accession>
    <name>A0A1U9NMQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69087">
        <property type="protein sequence ID" value="AQT69087"/>
        <property type="gene ID" value="STSP2_02274"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02274"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13560" checksum="27E980A049D2A631" modified="2017-06-07" version="1" precursor="true">MNHVMRRRKPRLMSKAESLFILLSVQALPASGLYGIRRKAWRDLMVGACGERENLSFRCQGRSTSGYNHECESTDADHRGGTFRSSDESFIMRWKRRECLIRSYCSVNRKRKEQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS3</accession>
    <name>A0A1U9NMS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine--fructose-6-phosphate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02410"/>
    <dbReference type="EnsemblBacteria" id="AQT69221">
        <property type="protein sequence ID" value="AQT69221"/>
        <property type="gene ID" value="STSP2_02410"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02410"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36443" checksum="6DC60C47A662F374" modified="2017-06-07" version="1">MKNEQKYTQFSLCQEMMDTPGVMRDFKLTDADAVVSAIKSTGKLFLTGEGSSRIFPAKNAITQYMRKGGDLQIMTEGGRQAAEYDLSNWAVFGASNSGSTAEVIMLLNALKGAGHDKLFGLTARENTKLAEMANQTFVLKCGWENAVAATKSVAEQALFYQAIVEAAQGRDISAKLGEVADACQTALTAEIDPTLTEKIANAGTIYFAGRNDGVAEELTLKTNEITRKKSDFLEGTYAVHGIEEVMNADDVVIFINPFDAELEKIKTTLVDGVGLTVIAISDKDTIFPTIKVPHVEGMETYAQLCAGWNILVEVGVKLGINLDKAERARKVGNEFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT1</accession>
    <name>A0A1U9NMT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02087"/>
    <dbReference type="EnsemblBacteria" id="AQT68910">
        <property type="protein sequence ID" value="AQT68910"/>
        <property type="gene ID" value="STSP2_02087"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02087"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12531" checksum="3578723947E81025" modified="2017-06-07" version="1">MKIQRQDYDEVSVIDLQGEFVSDYIKPFQDTVSSALADGSAGIVLDLSSITFIDSHCLEQLLWLRDYCLENQSQLKIAGLDETCAKILEITRLDAEFDSYDEVSRAVKSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW3</accession>
    <name>A0A1U9NMW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acoA_1</name>
        <name evidence="5" type="ORF">STSP2_02442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02442"/>
    <dbReference type="EnsemblBacteria" id="AQT69253">
        <property type="protein sequence ID" value="AQT69253"/>
        <property type="gene ID" value="STSP2_02442"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02442"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="418"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="745" mass="81025" checksum="B75EAE2E76644483" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX9</accession>
    <name>A0A1U9NMX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69157">
        <property type="protein sequence ID" value="AQT69157"/>
        <property type="gene ID" value="STSP2_02344"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02344"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23137" checksum="65B3C4D1644EC6C5" modified="2017-06-07" version="1">MAKRRPKKVLYEVAVSRSDSQDRVDRKERSARRAKRAVSELVSLNWSKLKIPAIAFFVALGIVIVLSQLNKEDRQQPAGSDSGAVASPRQPAQTGDRTSSESTASSGNASEIHVTGGTIIDQADKDNAIVIASNSDKKQLQAVQEFFAGHGIGSELIGTGRTWLLVSSEKYAGLSDMKRPIANIKKVGKDYDPPEGYKPFSFNTVYGINESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY1</accession>
    <name>A0A1U9NMY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69259">
        <property type="protein sequence ID" value="AQT69259"/>
        <property type="gene ID" value="STSP2_02448"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02448"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012414390" evidence="1">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="43967" checksum="9641364E4BD1E906" modified="2017-06-07" version="1" precursor="true">MDWQKMCSFCVVVFFGFSGILAFSADAESYAIVSPSTNDLDISSMIQPVGEENILSQEDHYVWGGSGIEGEDGKYYLFYARWPKGMTGRAEGDELFSGFRGWLKYSEIAVAVSDEPAGPFKHLKTIITGTKEEDKWHRFNAHNPHIKRFDGKLYLYYIGTNPAEGIANTWYAYANGQKIGVAVASSVQDFLAGDFEICDEPLVEPDEEKTHQRAVNPSVTRGHDGRYYMMFKSRAKPLGGKGDHMTHWCAASGSPDGPFELVGPVLQGGDYSAEDPYFWYDKGRERYYAIVKNFSRSKVLAPQFGALALITSTTPAKNWRPAKNSLVSLKQYTKPDGSVQKLNNLERPQLLFDGDGKPIALYAASAEKQPWNNNHTVNVQFKLAEPAEEAQGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN60</accession>
    <name>A0A1U9NN60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">metK_2</name>
        <name evidence="11" type="synonym">metK</name>
        <name evidence="18" type="ORF">STSP2_02571</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02571"/>
    <dbReference type="EnsemblBacteria" id="AQT69382">
        <property type="protein sequence ID" value="AQT69382"/>
        <property type="gene ID" value="STSP2_02571"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02571"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="15">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="16">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="17">
        <location>
            <begin position="251"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AQT69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="44976" checksum="5878D7A0C7F2C4EF" modified="2017-06-07" version="1">MAKKKTKPAGPGKANNGGHLFTSESVTMGHPDKVADQISDAVLDAMIAQDPHCRVACETMVTTGLAMVAGEITTDCYVDIPEVVRRTISEIGYTDPSIGFDGENCAVVTSIDKQSPDISQGVSEGEGMHKEQGAGDQGLMFGYACKETPVLMPMPIYLAHRITDRLARMRKNNKLPWLRPDGKSQVTVEYDDKGKPLRVHTVVVSTQHTEKVKYKALRKGIVEEVIMPVLPKRLVDDELIIHVNPTGRFVIGGPKGDCGLTGRKIIVDTYGGRGSHGGGAFSGKDPSKVDRSASYMARYIAKNVVAAGLADACEIQLSYAIGVAEPISVLANTEGTEKIDQREIERIVRKVFPLTPKGMIDHLKLRRPIYCKTARNGHFGHKDGDFTWEHTDMVDAIRKEAGMEPLKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN98</accession>
    <name>A0A1U9NN98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">iolG_6</name>
        <name evidence="8" type="ORF">STSP2_02466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69277">
        <property type="protein sequence ID" value="AQT69277"/>
        <property type="gene ID" value="STSP2_02466"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02466"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="208"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="456" mass="50019" checksum="6342C26F4F0AED0C" modified="2017-06-07" version="1">MAGHGSKSKDGISRRQFMGSAAAAAAAFTVVPSYVIGANGQTPPSEKLNIAAIGAGGMGAGNLRAMSGENIVALCDVDDKRAAGSYERFPDAKRYKDFRVMLEKQKDIDAVLIATPDHTHAVAAMAAMQAGKHVYVQKPLTYTVNEARVLTEAARKYKVATQMGNQGHSGEGCRLIHEWIHDGAIGPVREVHCWTNRPIWPQGIVKPAEAQEVPSTMDWDLWVGPSRMREYNSAYAPFNWRGWIDYGCGSLGDMGCHIMDAAVYALDLTKPSSVIASVSKDPTGEWKIDDRSGTYPAASVVHYTFPARGSMPPVKLHWYDGGIMPERPEDLEPGRRMPDSGTIFVGDKGKIMSGTYGGGPRIIPETKMRAYDRPERTLERVEGSHEQNWIDACKGGKPAVSNFEYAGPFTEMVLLGNIAVLNPDQRLNWDADAMKITNNEEANAWVKREYRQGWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA0</accession>
    <name>A0A1U9NNA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylR_3</name>
        <name evidence="2" type="ORF">STSP2_02277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02277"/>
    <dbReference type="EnsemblBacteria" id="AQT69090">
        <property type="protein sequence ID" value="AQT69090"/>
        <property type="gene ID" value="STSP2_02277"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02277"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="298"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="45317" checksum="F60E4F3C9747B0CD" modified="2017-06-07" version="1">MVDSSYAHNCDLIMQSYPYVLVLLESSREYGCGLLRGIATYSSLYGPWNLEREIPFYLANENSSEDNDPCRWVADGIITRDTTRARQLNRSLTPVIFASYMEEHTESAARLMTNDQSVGKMGAKHFLERGFRSFGYVGYKNMFWSTKRGVSFCEELQRNGFAAECYSQSAKDSGSDMLKEQLVLADWLKSLEKPCGVFCCNDDQAQQVVRASRHADLRIPEDIGVLGVDNDEIICTLANPSISSIALNLEAAGFQAAQLLDQMMSGEQVPPETIRVEPSYVVTRQSSDISAIQDADVAAAVSFIRRNCRKPIQVDDVLQAVSVSRRCLYEKFKRELKCGVYAFIKKKRVEQIERRLIETDMSICQIALEFGFTSTDYIAQYFRSQKGVNPLEFRKQFGSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC5</accession>
    <name>A0A1U9NNC5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mro_1</name>
        <name evidence="11" type="ORF">STSP2_02307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02307"/>
    <dbReference type="EnsemblBacteria" id="AQT69120">
        <property type="protein sequence ID" value="AQT69120"/>
        <property type="gene ID" value="STSP2_02307"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02307"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="41188" checksum="8E50DB7003F8975F" modified="2017-06-07" version="1">MNKLWMIICVSISIIFFAGCDMQKQAKVLDFDSIKLYELQNDAGMTVKITNYGAIVTSIVVPDRDGELADVALGYDRVEDYINAVDKPYFGAVVGRYGNRIAEGQFTLDGETYTLATNNGPNHLHGGTIGFDKVVWDGSYIQGDGYTGVELTYLAKDMEEGYPGNLNAKVTYKLTDDNELVIDYYATTDKATPVNLTNHTYFNLAGEGNGTILDHKLMINADYFTPVDSTLIPTGKLQPVKGTPFDFTSPKAIGRDIEQENQQLTFGGGYDHNFVLNKDGKNMTLAATVYEPASGRFMKVYTEEPGVQFYCGNFLDGRLKGKSGKPYVYRGGLCLETQHYPDSPNQPQFPSTILRPGDTYNTRTIYRFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI8</accession>
    <name>A0A1U9NNI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02367"/>
    <dbReference type="EnsemblBacteria" id="AQT69180">
        <property type="protein sequence ID" value="AQT69180"/>
        <property type="gene ID" value="STSP2_02367"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02367"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256699" evidence="2">
        <location>
            <begin position="23"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="276"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="613" mass="65550" checksum="4B82BCF6EAE22FF3" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL8</accession>
    <name>A0A1U9NNL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02398</name>
        <name evidence="9" type="ORF">STSP2_02799</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69210">
        <property type="protein sequence ID" value="AQT69210"/>
        <property type="gene ID" value="STSP2_02398"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69605">
        <property type="protein sequence ID" value="AQT69605"/>
        <property type="gene ID" value="STSP2_02799"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02398"/>
    <dbReference type="KEGG" id="alus:STSP2_02799"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="137"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="39413" checksum="7F4CAFBFD46FFF50" modified="2017-06-07" version="1">MMQVGLFDWQTRFEQLDNSGDPLVKLNEIVDWEQFRKTLEIVRDKKRKSNAGRKPFDVILMFKILILDSLYNISDDQLEFQIRDRISFMRFLGLGIGDRVPDAKTIWLFREQLTEAGLVENLFTQFDEFLRKNGFSAKKGQIVDASIVAVPKQRNTRDENKSIKNGEVPENWSDTKKRQKDTDARWVQKNGVNYYGYKNHIDIDVKHKFIRSCEVTPASVHDSNVFEDLLDANNSSKDVWADSAYGSTEKRDNIKEEGYRGHIQRKGCRYKKLTQRQIEANYKRSKTRSRVEHVFGIQKMRAGNLIIRTIGIARAKTKICMRNLAYNIDRYCLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS4</accession>
    <name>A0A1U9NNS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage 0 sporulation protein KA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">oppA_2</name>
        <name evidence="2" type="ORF">STSP2_02567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02567"/>
    <dbReference type="EnsemblBacteria" id="AQT69378">
        <property type="protein sequence ID" value="AQT69378"/>
        <property type="gene ID" value="STSP2_02567"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02567"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="84"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="598" mass="68730" checksum="D1E9476B8C6D5DD2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY0</accession>
    <name>A0A1U9NNY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">STSP2_02815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02815"/>
    <dbReference type="EnsemblBacteria" id="AQT69621">
        <property type="protein sequence ID" value="AQT69621"/>
        <property type="gene ID" value="STSP2_02815"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02815"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="260"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="41359" checksum="28F1DB160EAEF190" modified="2017-06-07" version="1">MNKKIALLGSTGSIGTNTLRVTESLGSHYEIYALTAHSKYELLAEQARKFNPAVVALTDPQLADKFKNALGDYTGEVLIGPDSLCTIAKMPEVNTVVTAIVGAAGLPAVLTAAEHGKTLAIANKEPLVIAGELLTEAAAKSGAKILPIDSEHSAIFQCLQAGKTSEVQKIILTASGGPFRTASPEQIKNATLEDALDHPTWSMGPKITVDSATMMNKALEVIEAVWLFGVPVDKIEVLVHPESIVHSLVEFVDGSVMAQLGAPDMCTPIQYALTYPDRETGIASHLDLAKLGQLSFEPPNLDNFRALKVGFDVAAAGGSAPVVFNAANEAAVKIFLEGGIKFARITELIEECVDKHQVRQHISLEELLEVDKWAREFVSNAASKSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ2</accession>
    <name>A0A1U9NNZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02827"/>
    <dbReference type="EnsemblBacteria" id="AQT69633">
        <property type="protein sequence ID" value="AQT69633"/>
        <property type="gene ID" value="STSP2_02827"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02827"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010738406" evidence="2">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="40662" checksum="F2C7797723A3D0B9" modified="2017-06-07" version="1" precursor="true">MRTSHVLSLVIVALLIPAIVGCQEPQAAKSTTVETQSQQQIVSPDQADQTQTDAPATGDTASAEKKDAPNVTVEDNEHNFGIVGPGTVHKTEFEFKNTGSKPLKVIDIKSTCSCTVPALKKKTYEPGESGKFSVTYTASEHEGTDKKHLYILSNDPDEPRKQVTIQAKIELDIEYGPQRMNLSLKEDNAGIPNITLKSKDGEKFAVKSFSTVRDVITANLDPDKKASEFTIKPKVNLEKLSKNLTGSITLTLDHPTTKRLRIFYTTQPLFEVTPARIIFQNAQRGETMKRTILIKSNYAENLKVESVESRDGQIEVVNRKSLGDRAQLEVEFTAPEDNKGRFFSDKLTINLENGEKLEINASGWIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ4</accession>
    <name>A0A1U9NNZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02425"/>
    <dbReference type="EnsemblBacteria" id="AQT69236">
        <property type="protein sequence ID" value="AQT69236"/>
        <property type="gene ID" value="STSP2_02425"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02425"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="258"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="52115" checksum="BDAE7941D79CD076" modified="2017-06-07" version="1">MEAKVHFLGAAGNVTGSRHFLEVNGTRILIDCGLYQERHLRDRNWAPFPVPAHTIDAVLITHAHLDHCGLLPKLVEEGFKGKIYCNAATAEIAQIVLMDAGHLQEEDAAFKRKRHRKEGRKVDHPVIPLYTTADAEATIPLFSPVLYEEPVQIGEYVTATFHNAGHILGASTIKLKISDDDGENRTVLFSGDIGRGDRPIICDPAVFEHADYVFIESTYGDRVHEGTDDIKGNLADAINETYQKGGNIIVPSFSVERAQDVLYYLNELLLEDRIPPILAFVDSPMAVKVTDVFKKHPELYDDEMKELVARHESLFEFPGLQLVRTTKESKAINNIKGTVMVIAGSGMCTGGRVKHHLVQNIWRPESSVLFVGYQAVGTLGRSIVQGDNPVRILGQQYDVNATITRIHGFSGHADRDELLAWLKNLKTAPKQVFVIHGEEQSANSFADHVTQQTGWKTSVPQYDEVVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP17</accession>
    <name>A0A1U9NP17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69692">
        <property type="protein sequence ID" value="AQT69692"/>
        <property type="gene ID" value="STSP2_02887"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02887"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012550049" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="72" mass="7903" checksum="0F49791782DD57CC" modified="2017-06-07" version="1" precursor="true">MIMLKNCVLAVLVLVAVFMSGCCPMCVEREDGDAGSCEIRGESTSEKLDNSGIQIDMSFEGSRSELSYFRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP23</accession>
    <name>A0A1U9NP23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-D-glutamyl-L-diamino acid endopeptidase 1</fullName>
            <ecNumber evidence="2">3.4.19.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.19.11" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02857"/>
    <dbReference type="EnsemblBacteria" id="AQT69663">
        <property type="protein sequence ID" value="AQT69663"/>
        <property type="gene ID" value="STSP2_02857"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02857"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29492" checksum="25B244C060AC277D" modified="2017-06-07" version="1">MVKNFWAGLLGRYASGILTVCLFAFMAAGIAGCDTWGQERVSKPEFSWSVPGKSVQGRPIECLSMGNGERTVLVMATIHGDEFAGTPLVRKMIDHLNKNPQKLARLRVVVMPMANPDGYALGQRYNANGVDLNRNFEAENRVNNEVNGPRGLSEPESRVIRDIIRSYRPERIITLHQPLECVDYDGPAGDVAYAMARCCDLPLNKLGSRPGSLGAYAGERLSIPTVTVELREEDSQKSADELWRAYGRMLLAGVFYPEPVTDFIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP31</accession>
    <name>A0A1U9NP31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superoxide dismutase, Ni</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02669"/>
    <dbReference type="EnsemblBacteria" id="AQT69478">
        <property type="protein sequence ID" value="AQT69478"/>
        <property type="gene ID" value="STSP2_02669"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02669"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775680" evidence="2">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19765" checksum="7C6D55AA5D896AD8" modified="2017-06-07" version="1">MKTKAITVIGLLMAAAAPIVYSHCQIPCGIYDDQARIGSMAEDIRTIEKSMKQIEELSIDPGKNANQLVRWVTNKEEHAQKFSEDVTYYFMAQRLAPPEEGASVETQKEYNKQLTLLHKLLYNAMKAKQTTDLEYVAELRALLGDFEKAYFDEDSQAAMSDHGHEHGQAGHVHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP46</accession>
    <name>A0A1U9NP46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bfmBAB</name>
        <name evidence="8" type="ORF">STSP2_02809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02809"/>
    <dbReference type="EnsemblBacteria" id="AQT69615">
        <property type="protein sequence ID" value="AQT69615"/>
        <property type="gene ID" value="STSP2_02809"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02809"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35876" checksum="E7177AEF67B46718" modified="2017-06-07" version="1">MAVISYRDALNQALDEEMTRDDSVLLMGEEVAQYNGAYKVSRGLWDKYGDKRVIDTPITEEGFTGIGVGAAIAGLRPVVEWMTFNFSIQALDQIVNNAAKMRHMSGGQLKVPIVFRGANGPAEYLSSQHSQALATYYAHVPGLKVVAAATPYDAKGLLKSAIRDDNPVVMMEAELLYGIEGEVPKDEYLVPIGQADIKRPGDEVTIISFGKVVHKALDAAKQLENEGISAEVIDLRSLRPLDEEAIIKSVQKTNRCVIVDESWPVCSFGSYVSHIVAHNCFDVLDAQVELISSIDVPMPYNHTLELAVQPSVKKIVRAAKKVLYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP58</accession>
    <name>A0A1U9NP58_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AQT69689.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="717" mass="74821" checksum="79B94918477992A8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP92</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
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    <reference evidence="2" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <property type="gene ID" value="STSP2_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02515"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="133" mass="15576" checksum="95A4834EF9D5004F" modified="2017-06-07" version="1">MLIASADKLTNRYDSATTGYDVTCTYDDAGNTTTDQNGYQYTYDYENRISQIKDASDSLVASFNYDALGQRIRKVDHKTTANTRIYYYNDNWQVLTEYDGSDTFKRYRKAFAKLLLNLRPEFFFGWQGVQNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD0</accession>
    <name>A0A1U9NPD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate-flavodoxin oxidoreductase</fullName>
            <ecNumber evidence="14">1.2.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nifJ</name>
        <name evidence="14" type="ORF">STSP2_02890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.-" evidence="14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02890"/>
    <dbReference type="EnsemblBacteria" id="AQT69695">
        <property type="protein sequence ID" value="AQT69695"/>
        <property type="gene ID" value="STSP2_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02890"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="982"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1091"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT69695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129285" checksum="645E07046161AF15" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI5</accession>
    <name>A0A1U9NPI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis transcriptional regulatory protein PhoP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP</name>
        <name evidence="6" type="ORF">STSP2_02711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69520">
        <property type="protein sequence ID" value="AQT69520"/>
        <property type="gene ID" value="STSP2_02711"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02711"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="236" mass="26337" checksum="FBC000F5BB8CDCB8" modified="2017-06-07" version="1">MANERILIVEDEEDVLELESYNLKKNGYNVEAATTGEQALEKALNHTFDLVLLDIMLPTVDGLEVCKILKTNPQTAEVPIIMLTAKGEESDIVAGLELGADDYITKPFSPRVLMARVKAVLRRKRKPTPEESETVRRGPIEIHPNRHMVTVEGQNVDLTSTEFSLLHLLARKPGWVFTRYKIVDAIHGTDHAVTDRSVDVQVVGLRKKLGSAGKLIETVRGVGYRFKDLSAEQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ7</accession>
    <name>A0A1U9NPJ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">STSP2_03060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03060"/>
    <dbReference type="EnsemblBacteria" id="AQT69862">
        <property type="protein sequence ID" value="AQT69862"/>
        <property type="gene ID" value="STSP2_03060"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03060"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24455" checksum="B360C6E56929F40F" modified="2017-06-07" version="1">MAKKSKRYRADAEKTTGKEVLPLSEAIKKVKGWDSTKFDQTVELVMHLGIDPKQADQMLRGAISLPNGIGKQKKVIAFCEDSDVEAAKNAGATEAGTDELVKKIEDGWTDFDVAIASPKVMGKVGKLGRVLGPQGKMPSPKNGTVTPDVVSAVKEFAAGKVEYRNDKNGNLHVVVGKLSFSEGKLKENTDAFISHVKKIRPSSVKGGYIKKVCLTATMSPSVQVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN2</accession>
    <name>A0A1U9NPN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT_4</name>
        <name evidence="3" type="ORF">STSP2_02763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02763"/>
    <dbReference type="EnsemblBacteria" id="AQT69570">
        <property type="protein sequence ID" value="AQT69570"/>
        <property type="gene ID" value="STSP2_02763"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02763"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="359" mass="40311" checksum="F0813BE8006B5A6F" modified="2017-06-07" version="1">MINIKEILAESIEQSASDLHINVGLPPIMRVHTELIAMEYPAVTDEEARQMVLEMVGQDKFQEFEEKRDLDFSTYIDDGSRFRVNAHYQRESIALSFRAISNYIPVLDELNLPDIVKELTELPRGLVVVTGHTGSGKSTTLASMIGSINEKRSKRIITLEDPVEYALENDNCMIEQREIGADCVTFASGLRHVLRQDPDVILVGEMRDLETTSSTITAAETGHLVFSTLHTVNASQTVERIIDIYPGSQQNQIRAMLSNTLQAVISQTLFRRVDKPGMVPCTEILLCTSAVRNCIRENRVFEIPNIIETSRKIGMQSMDNSIADMYFRGFIDREEAVMRSSNPGKMEKLFSQHGNAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ23</accession>
    <name>A0A1U9NQ23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide-specific efflux protein MacA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macA_2</name>
        <name evidence="5" type="ORF">STSP2_02906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69710">
        <property type="protein sequence ID" value="AQT69710"/>
        <property type="gene ID" value="STSP2_02906"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02906"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="66"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="50592" checksum="DE7F14C920511130" modified="2017-06-07" version="1" precursor="true">MTLRWILKKRVIIPAMLIVGAVFAAGKMKSGGPVEDAGKLVRVATPERGELVEIVSGPGQVMPKTKVAISAKVSGRIEELPFEEGDRVVGGTKEKPGSLLVRLESRDLESQLRSAKAQRMAQEAQIEVEMARIAGQKANLEGMDASLEQAKKDFERQKKLHESKDISLATLDQAECNLAELRASYKQAKASIEAAELNLEVLKHNLEVAEARIEEAEETLGHTVIRSPIDGIITKINAEVGEIAMTGTMNNPGTVILEVADLSKMIVETEIDEADVGQIEVGQRAKVHVQAFDDTVFEGTVDSIALTHGMSRTGSKFYETEILLDKTAKMLYSGLTADVEVLTERHEDALKVPSQAVVGREVDTLPLEIRNSSKLVDTSKRYATVVYKLVDGKAVATPVETGASDMTHIIIEQGLGEDDQIVVGPYKILESLKNGMAIRDENGEQAEKAIAGKEDDSAETADAGKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD3</accession>
    <name>A0A1U9NQD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain/BON superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03323"/>
    <dbReference type="EnsemblBacteria" id="AQT70119">
        <property type="protein sequence ID" value="AQT70119"/>
        <property type="gene ID" value="STSP2_03323"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03323"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30324" checksum="5F62D16F5BD46156" modified="2017-06-07" version="1">MTSDAKVGLLLGLVFVVIIAFLINGLPDLLGSNEAEQPVSTAISNSHTTTLVIGEQARQAGQQVLGPDPTEELAPRQVSIAEASEIDPRFSDNPPSASNPGGSISRRIPTGTPTTTSQTGSSAGGYYVVRPGDNLAEIAKKFYGPEKGNKHENVKRIYEANKQTLPSPDKIKSGQKLLIPALSVTQRAPKNVKDAQKMGLFEKIASIPDAWKKAGRNESRPEPPRQNRVYVVQPKDTLWNIAAKYLGSGHKYRQIVELNKDKLSDPGDIEEGMRLTLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ5</accession>
    <name>A0A1U9NQJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70095">
        <property type="protein sequence ID" value="AQT70095"/>
        <property type="gene ID" value="STSP2_03297"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03297"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="27780" checksum="BEA73B1C72CC3754" modified="2017-06-07" version="1">MSDQNDLNKLVDDKLKQAIDARKELIALDDDCDLADKLDCLKLFVKAAFDYADFSWKKGSEYYNQDMAFGLCKTAYTFATSYMQTCENITLSLTCPQKPEEGELAALINLQNRLDEIIEKVGESRDSEDSQPTPDKRQIRAMIRKWNPDILAKNAEAAEMVIWHGAMFERYYKFIREHDSKDLPKRGRDDLDPLIKDILEIRDNLTADAVCGAVNLIQSGKFNPTTKATVFKTQAWKARHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK3</accession>
    <name>A0A1U9NQK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70213">
        <property type="protein sequence ID" value="AQT70213"/>
        <property type="gene ID" value="STSP2_03419"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03419"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="69" mass="8077" checksum="502C0A87B00E7B25" modified="2017-06-07" version="1">MARGIEKHVDHHYYMEHAAHKLNVMLHDPRVWAILALILAAALIILYAAWSEGTSPESVEPRFEYFPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV1</accession>
    <name>A0A1U9NQV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70098">
        <property type="protein sequence ID" value="AQT70098"/>
        <property type="gene ID" value="STSP2_03300"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03300"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18936" checksum="34EC3BD562F0D7E2" modified="2017-06-07" version="1">MTDMYIKIFPEVMELPELSHSAKLVYCAVLSFRGRALKMSNACIAQLTGRSVRTVKQTLTTLRSLGLIYLENEQSRYRRIYPTTEIEESTGEKLRPYWGNLAPLLGKLVTHRRKEGNRSNAGSAGYESSCEVPVGDDSELLGIPELYPTQGELEELGLHEGKEVIDEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW5</accession>
    <name>A0A1U9NQW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70118">
        <property type="protein sequence ID" value="AQT70118"/>
        <property type="gene ID" value="STSP2_03322"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03322"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="9346" checksum="47A9F997C7DA96CB" modified="2017-06-07" version="1">MSRPRLVLIVFFATLVLIVTAWLRSASSRTFYLHRQEYVRQQRLKQQLWQKQLELESIISPTTISDRIEKQLEDDQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR15</accession>
    <name>A0A1U9NR15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="15">BCAT</shortName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvE</name>
        <name evidence="16" type="ORF">STSP2_03471</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 15">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03471"/>
    <dbReference type="EnsemblBacteria" id="AQT70265">
        <property type="protein sequence ID" value="AQT70265"/>
        <property type="gene ID" value="STSP2_03471"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03471"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31363" checksum="A35399E98C28216E" modified="2017-06-07" version="1">MGLKIWQNGELVDEAQAKVSVFDHGLLYGDGVFEGIRVYSGNIFEFEAHIDRLYESAKAIRLDIGMDKRPLMDATEETVKANEIEDGYIRLLVTRGVGDLGLNPFVCGKAGVIIIAANIQLYPEEFYETGLKVISANAVRTHPLTLPPQVKSLNYLNNILAKIEAIDHGVGEVVMYNPQGYVAEASGDNIFIIRKGELFTPPIQAGALDGITRQVVMKLARESGYTVTERNLTKFDLYIADECFLTGTAAEVIGVVEIDGRIVGDGKPGAVTKELRKKFFEYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR38</accession>
    <name>A0A1U9NR38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70090">
        <property type="protein sequence ID" value="AQT70090"/>
        <property type="gene ID" value="STSP2_03292"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03292"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13615" checksum="E4BE362D4D3A7DE1" modified="2017-06-07" version="1">MWLCTRYDFFSVVRGDDRISPGKVMVRARKAGHLRNLQGRFAELRDVPLKTSSTTDYPCRLVVNREVWARIGAELAADIDYTNFKNAAGGELADDSDYSEFLHEVWWKGMQLLQRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR65</accession>
    <name>A0A1U9NR65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70234">
        <property type="protein sequence ID" value="AQT70234"/>
        <property type="gene ID" value="STSP2_03440"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03440"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013138081" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="593"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="825" mass="93059" checksum="BAA76E1701ABA896" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR99</accession>
    <name>A0A1U9NR99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70056">
        <property type="protein sequence ID" value="AQT70056"/>
        <property type="gene ID" value="STSP2_03258"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03258"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14909" checksum="3B87335468A713D5" modified="2017-06-07" version="1">MDRYIEVRARVRIPIEKIQDMIITAVEGGSNYWAKFQFPENYKDKFGSYEKIPFADENIEVFDIETGELLGVVNKEGIQKALQMMADCKDKRGRHVPERHFRNLAMDNEDAETADVFMQLAVMGEIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC1</accession>
    <name>A0A1U9NRC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane-specific lipoprotein transporter subunit LolE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03474"/>
    <dbReference type="EnsemblBacteria" id="AQT70268">
        <property type="protein sequence ID" value="AQT70268"/>
        <property type="gene ID" value="STSP2_03474"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03474"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="441" mass="47799" checksum="4C3B23128D44D06E" modified="2017-06-07" version="1" precursor="true">MKHLSVVLCRRYLSKKKIVLLSVASVAMSCALLVVVASLFTGFIASFESTVSDHVGDVVISGRRGVLIEQYDRLIAELDELDEVESSTAVLSGKGGLLFLGPGNVRAVQLYGIEMPRRSKVTPFGDMLVRQKGSDSASFTPEWVKGGTGGFLGIGVISSPDEKTDEYDMAEVQDFIGRKVVLTTGDGQSTKTQLVKFTVADVVFSGFHWADKDFVYLPMERVLDEFYPDSGKVADMVQIKVAEGYDPAATVAQVRSVWERFADQELGWSLPRIAAVQVQTARQNWARLISEYQKQLGMLMVIFGVVSGGVVLLIACIFYMIVITKRRDIAVVKSCGMGGFSVAGLFLFFGSIVGVVGSGIGIAAGYVITKNINSIEAAISSTFGLKLWQSSTYMFSTIPDDMNWSAAGWVVIASVIASMIGAIIPAIRAATLRPVKILRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRD2</accession>
    <name>A0A1U9NRD2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="7">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Osmoregulatory trehalose synthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">otsA</name>
        <name evidence="14" type="ORF">STSP2_03484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03484"/>
    <dbReference type="EnsemblBacteria" id="AQT70278">
        <property type="protein sequence ID" value="AQT70278"/>
        <property type="gene ID" value="STSP2_03484"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03484"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT70278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="730" mass="83956" checksum="978807146D3A52E5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG83</accession>
    <name>A0A1U9NG83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66941">
        <property type="protein sequence ID" value="AQT66941"/>
        <property type="gene ID" value="STSP2_00079"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00079"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="18606" checksum="194C24C3327C6498" modified="2017-06-07" version="1">MKKLFPIISIIAIVLMFSAEALGKVTVRVRISGGGYSSYVVTGSPALICYYPGCSRTYTHYHGDGLIITNRRYGYDSRYPYYYRYQKPYYRHYNRRHYYNPYYRRYTPSHRYHRYSIPRYHRAPSLRRHYYHRRVPVYPHGGTGHYQYKLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE4</accession>
    <name>A0A1U9NGE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cph1_1</name>
        <name evidence="2" type="ORF">STSP2_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67001">
        <property type="protein sequence ID" value="AQT67001"/>
        <property type="gene ID" value="STSP2_00139"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00139"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23274" checksum="5C7EBD5246664B23" modified="2017-06-07" version="1">MHDKAAAQQVNRLISDEVGQEVSFITASVKKLDSLQRGLLALSRLGRVELDKDLIDMDELVKKIFTLQEEQVLAAKAEIDIDHLPNCCGDQQLISEVFSALLDNALKYLDPQRKGLIRISGHARDGMCRYSVRDNGIGISPEHQKKIFEVFHRLTPNGDTMGRGLGLTLARRIVLRHKGHIWVQSQEGQGSTFWVELPAADTQNKTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL4</accession>
    <name>A0A1U9NGL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trk system potassium uptake protein TrkG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trkG</name>
        <name evidence="11" type="ORF">STSP2_00083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00083"/>
    <dbReference type="EnsemblBacteria" id="AQT66945">
        <property type="protein sequence ID" value="AQT66945"/>
        <property type="gene ID" value="STSP2_00083"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00083"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT66945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="506" mass="55651" checksum="DCC436268EC30B67" modified="2017-06-07" version="1">MNYKVVFKQLGVLVFLVGACMSTSLIWAFLDRKEEDFGQIASAFLLSIFICIGIGLILNFRRTQTKKMYRKEAIAVVSIGWFLCGILGALPYIFSGVLAPLYDGWFSICSAAVFESISGFTTTGASIFPEPESLPRAILFWRSLTHWLGGMGIIVLFVAILGEAGSGAKHMVISEVPGLPDEAPRPRIRSAAMLLWNIYVAISVAEVIALNLQGMSIFESLCHTFGTMATGGFSTLNGSIGQYNNLGYEITIIVFMLLAGTSFNLYAILLGGGWRRVLSNREFQIYLLIVLCAVILLTTDIILDGPEEYTAGKALQDSSFQAVSIMTTTGYGTADFDRWPDFSRWLLVLLMFVGGCAGSTGGGLKVIRVVLFFKILSLEIASVFRPRAVKTLKIGDRPVDKSVRQNVTAYLGLVLVIFFLSTLILFILHNDYCMQKEDRINIETAFSSVAATLNNIGPGLAMVGPTENYAFFSAPAKLFFSLLMILGRLEVMVILCMFMPSFWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN0</accession>
    <name>A0A1U9NGN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliF</name>
        <name evidence="14" type="ORF">STSP2_00032</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00032"/>
    <dbReference type="EnsemblBacteria" id="AQT66894">
        <property type="protein sequence ID" value="AQT66894"/>
        <property type="gene ID" value="STSP2_00032"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00032"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="248"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT66894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="54303" checksum="D2E1FCC50AEEE594" modified="2017-06-07" version="1">MNFVQNIAAAWQRVGLVQKALLIAIAVACVIGGTVLTKWASKPDMRLLYSDLTPDVAGKITDKLSEKAIPYELRGGGTSVYVPRKHVYQMRVDLAKDGLPGNESQGYKLFDNEGIGVSPFVQNINKTRALQDELARSISLFDGVTNARIHLVRPEGNVFNSGEEDSSASVVLRLKPGYRVGQTTVASITHMVAGAVESLKAENVTVVDSQGQLLSSRHDEGLAGGPSTFMDYKDRVEQTLSRKAEDMLMAALGPGRASVKVSAVIDMESEDVQTVTYQKGVPTKEEINTTSKTTNNDGEQASGGDNESEEQILTEYQLPETTTRKTKIGGQIVSLSVAAVVDLSAPEPEPTATEGEEGGEGTTNTTSTTSSQPIMAVEDVKQLIITALGKDLLTEENLSVVSTKFNRPQLPVEEEADVPFWEPYIGLIRNASLGIMAVCALGVLKIMGGGKAKAPVAASGGEANLSGGEQASSTNMLPAGEVRAQIAHALQSDPDQVRELFNSWLQEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ1</accession>
    <name>A0A1U9NGQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar hook-associated protein FlgL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00052"/>
    <dbReference type="EnsemblBacteria" id="AQT66914">
        <property type="protein sequence ID" value="AQT66914"/>
        <property type="gene ID" value="STSP2_00052"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00052"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="4">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="42803" checksum="CF3336766651C8AF" modified="2017-06-07" version="1">MSYSSFGTMFRTTSWALQSHTQALTYLQQQASTGNRIIKPSDDVSDANRILTLRTEIRDVDHYMTEMDRVVNRFNSASANLELISERLTGLKGDLTRVMSMDASARQGVAAGMDDLINQMVSLANTKHQGQYYFGGDNSSIPPYKVEKKNGQIDRIVYQGSTAERRVELSPGVEIGANFVGDDIFRASGDRQIFFVESNTGAVAGTGTSSVKGDFELEVTHDGTNYQISIDGGLSKTTVPVGGEANTAVTDSRTGEVMYVDTTGITQTGTDQLSVRGTHDVFNLLIKIRNLLKDTDTEAADVQLDEAIKSLQEVHDKVAADLTLVGSRITSLQTVVDSFENVKVNSEEEATTLQQADIAQVAMDLTRRQTLYQMSLSVTGKLMSTSLVDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV1</accession>
    <name>A0A1U9NGV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67035">
        <property type="protein sequence ID" value="AQT67035"/>
        <property type="gene ID" value="STSP2_00174"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00174"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="413" mass="45862" checksum="B9F8819B00A96C72" modified="2017-06-07" version="1">MAKPDLENSVIFRFSLYGFLKNQRYFEPFLILAFHADKGLSFFAIGLLIGFRELMINLLEIPSGALADLYGRRMCMITAFVAYTISFVVFGVSSVLWHLYIAMLLFAVGEAFRTGTHKAMIFAYLHSKGADDMRVQVYGFTRSWSKIGSALSAAIAGGLVFWRGNYSDIFWLCAIPSAMNVINFMTYPDVVEAGRNTDVRGMRVFGHVWESVKIAWSRRAQRMLLLESSGFEGVFKIAKDYIQPVIKSVAIGLPFLAALEDQQRTAILIGLAYTLVHLVSSVASRRAHTIGKWAGGDESSAMWIWGVVMVCYALLVATLGFGWFAIATPVFVAVYMLQNFYRPLLVSRLNAVSEKHQAATTLSIESQLKSLVAMIVAPLLGFSVDQWGLWSVGLAGFVVSAAFWLNGRIAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH10</accession>
    <name>A0A1U9NH10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaBC_2</name>
        <name evidence="2" type="ORF">STSP2_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00364"/>
    <dbReference type="EnsemblBacteria" id="AQT67221">
        <property type="protein sequence ID" value="AQT67221"/>
        <property type="gene ID" value="STSP2_00364"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00364"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22238" checksum="A19F0D1C36CEFCAC" modified="2017-06-07" version="1">MNITITAGGTREYIDPVRFISNASSGRMGYALAAAARDAGHSVTLITAPTALQPPDDVTVINVTTSEDMFTAVRSAFPATDCLIMAAAVSDYRPAKTSSTKIKKSDAELTIRLEPTTDILRWAGQNKTTQLIVGFALEDTDLETRAEKKLRDKNADMIIANAPSAISADESALKIKTPNTPWQTLPPAPKQTNAKKIITEIEKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG8</accession>
    <name>A0A1U9NHG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">STSP2_00398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00398"/>
    <dbReference type="EnsemblBacteria" id="AQT67255">
        <property type="protein sequence ID" value="AQT67255"/>
        <property type="gene ID" value="STSP2_00398"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00398"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19073" checksum="13E09DEC33AF1767" modified="2017-06-07" version="1">MTRDQLVKRVKDVAYLEGDFVLRSGKRSKYYLDKYLFETQPDILKALGEEFAKYVTDDVTLIAGAELGGVALAAATAMQAEKPWIIVRNSKKDYGTSKMVEGVLKETDVVLLVEDIATTGGQVCEAAKIITDAGAKVKKIVSVIDRKQGARENITDAGFDFDSIMTKEDLGITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI4</accession>
    <name>A0A1U9NHI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">STSP2_00527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00527"/>
    <dbReference type="EnsemblBacteria" id="AQT67383">
        <property type="protein sequence ID" value="AQT67383"/>
        <property type="gene ID" value="STSP2_00527"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00527"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20706" checksum="D32B1A584AADC0B5" modified="2017-06-07" version="1">MKASDMKKGQTVTVDDKLYVVVDYQHVKLGKGGAVYQTKLKGLEDGGTRNIRLRADENVEEAYLDKRNYEYLYSSADEHVLMDTENFEQIMLDDDAFGDGPKYLKPNEQLKVSMYEGRPVVVELPNTVDLEVTETAPEIKGATATNQYKPATVETGYELQVPPFIKVGDVVRVDTRSGEYVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK3</accession>
    <name>A0A1U9NHK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67401">
        <property type="protein sequence ID" value="AQT67401"/>
        <property type="gene ID" value="STSP2_00545"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00545"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16596" checksum="AD1A274F26F412D9" modified="2017-06-07" version="1">MPHQAKDKTTEHALEKKYPASVLKAADRFLARSHLTLGELTRPQAELLLQHFRSKSNLKWFVIIAIIIIAIAGSATTLAAALLPQTLNELIKNQPQPEMIQRLAFGAAATGAVIALVLFSAAIAITTTVGEIVRARHTTRIIEEFLPRRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS0</accession>
    <name>A0A1U9NHS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dmdB</name>
        <name evidence="2" type="synonym">leuD</name>
        <name evidence="4" type="ORF">STSP2_00437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00437"/>
    <dbReference type="EnsemblBacteria" id="AQT67294">
        <property type="protein sequence ID" value="AQT67294"/>
        <property type="gene ID" value="STSP2_00437"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00437"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17933" checksum="3D292FAFC175426D" modified="2017-06-07" version="1">MAKAHVYKRDHINTDEIIPARYLNTDDHAELAKHCMEDLDTEFVNKSQPGDVIVAGEDFGCGSSREHAVWALQGAKVGAVIAQSFARIFYRNCINCGFYPIELPEALHAIKDGDKLAIDYDAGIIYNETRGEEISFSPLPDFALEIVRDGGLLDHIKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS6</accession>
    <name>A0A1U9NHS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67308">
        <property type="protein sequence ID" value="AQT67308"/>
        <property type="gene ID" value="STSP2_00451"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00451"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527452" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7908" checksum="AE25FBAECAF74932" modified="2017-06-07" version="1" precursor="true">MKICKAVLLSMLLCVVLVNVTGCSNLGETRAEASRRYERILRINTNQIGHDLDLIFMMDKPSTLTPMLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ3</accession>
    <name>A0A1U9NHZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67368">
        <property type="protein sequence ID" value="AQT67368"/>
        <property type="gene ID" value="STSP2_00512"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00512"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19876" checksum="1CE99138D68D7041" modified="2017-06-07" version="1">MYKNLVNNKLAKQVLFWAGFVGVWFVYAFFMDAVVGRPLDRGDTAIAMRRFTGVVLAGMLAYLVWVYKTWQRDRFWRFDVAGMMLVCGLFGVGIFYKTEMMTVLGFISFFVLSDFRFIRELKRDRHLAGSKNIRERVGYWITVVNTVLIALMIIMLSAVGFVMLVYVLGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI10</accession>
    <name>A0A1U9NI10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase 2</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA2_1</name>
        <name evidence="13" type="ORF">STSP2_00551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00551"/>
    <dbReference type="EnsemblBacteria" id="AQT67407">
        <property type="protein sequence ID" value="AQT67407"/>
        <property type="gene ID" value="STSP2_00551"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00551"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23157" checksum="3754080FFC3ACC4E" modified="2017-06-07" version="1">MADKNDKRIIKHVPNALTMGRLVMTVVFLAMIIIAGDREKPGSNYLLVTFILFVVTGLTDIVDGKIARMYDVTSKFGRIADPLADKFLVIGAFVCFAIAQQPRLDAFGWSEGTLDVLRWGTAGIIFLREVVVTIRRQIAESRGVKFGAIASGKLKMFLQSFGIGTVIIGWAYVERAWGDWFTLAVYALMIGATVYSGIESIMRPIKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI19</accession>
    <name>A0A1U9NI19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">msrA</name>
        <name evidence="7" type="ORF">STSP2_00561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00561"/>
    <dbReference type="EnsemblBacteria" id="AQT67417">
        <property type="protein sequence ID" value="AQT67417"/>
        <property type="gene ID" value="STSP2_00561"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00561"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323959" description="Peptide methionine sulfoxide reductase MsrA" evidence="5">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PMSR" evidence="6">
        <location>
            <begin position="58"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23658" checksum="C480262B390DDB05" modified="2017-06-07" version="1" precursor="true">MRLNKTILFLFTAAVIISLMAGCGAHGKEAHMNNTELRSVQQASIVGEKAISENVQSATFAGGCFWGVEAVFRQTEGVVATAVGYTGGSKENPTYREVCTGRTGHAEAVRVYYDPDKTNYAKLVDKFFASHNPTTLNRQGPDVGTQYRSAIFYHDESQKEIAKKTKEALQDSAKFERPIVTEIKPAGPFYMAEDYHQRYFEKNKGAYCPHPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI66</accession>
    <name>A0A1U9NI66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ruvC</name>
        <name evidence="15" type="ORF">STSP2_00780</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00780"/>
    <dbReference type="EnsemblBacteria" id="AQT67632">
        <property type="protein sequence ID" value="AQT67632"/>
        <property type="gene ID" value="STSP2_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00780"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17386" checksum="C2F29AA548201D4C" modified="2017-06-07" version="1">MRIMGIDPGLQVCGYSVIDDGQRDMRLIEAGVFRTDRSKSLETRLNQIAADVEHILDKHGPDVVAVEELYAHYKHPRTAILMGHARGVIFQKSAASGAEVKSYSATRIKKSLTGHGRASKEQMQRAIQTVLGLAEAPEPHDVADAIAAALCCANAVRIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH0</accession>
    <name>A0A1U9NIH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ORF">STSP2_00871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00871"/>
    <dbReference type="EnsemblBacteria" id="AQT67723">
        <property type="protein sequence ID" value="AQT67723"/>
        <property type="gene ID" value="STSP2_00871"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00871"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="248"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="515"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="789" mass="86947" checksum="09B1A96E4CC8ED74" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ6</accession>
    <name>A0A1U9NIQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00963"/>
    <dbReference type="EnsemblBacteria" id="AQT67813">
        <property type="protein sequence ID" value="AQT67813"/>
        <property type="gene ID" value="STSP2_00963"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00963"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18502" checksum="39F5735A80B40067" modified="2017-06-07" version="1">MNRRKLTIRDETPSDIAAISRITRAAFKTCPYSNDTEHLIINALRAADALTISLVAELDGTPAGHVALSPVTFSDGSTDWFGLGPIAVIPEKQKQGIGTALMNRALEQLRTHNAAGCILVGDPAYYTRFGFTAYPQITHEGVPPENVLALPFTDHLPTGQVTFHKAFSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR2</accession>
    <name>A0A1U9NIR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase involved in intracellular survival</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00540"/>
    <dbReference type="EnsemblBacteria" id="AQT67396">
        <property type="protein sequence ID" value="AQT67396"/>
        <property type="gene ID" value="STSP2_00540"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00540"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20856" checksum="FE5B62D0EE05D7E2" modified="2017-06-07" version="1">MTEEINIYRENDMPADIDARIRQYLADAFPHRHDDFLRSRTLRRNVPFYTVVLEIDGDPVAHVQVMDRTIDVGGAPVNVAGIGNVYVAPAHRGKGYSDRVMRVAMEEADRLGFDFGMLFVITPIKKVYERTGWIEISPRKFMHIHQGEELEVPTERHRMFYPLKSKEFPPGDVNLQGDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS9</accession>
    <name>A0A1U9NIS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="10" type="ORF">STSP2_00782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00782"/>
    <dbReference type="EnsemblBacteria" id="AQT67634">
        <property type="protein sequence ID" value="AQT67634"/>
        <property type="gene ID" value="STSP2_00782"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00782"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18839" checksum="C68B8D0039525BA3" modified="2017-06-07" version="1">MNLDLKYEYRTGIGTDIHKLVLDRELKLGGVEVPYPKGLLGHSDGDVVLHAVIDAVLGAMCAGDIGTLFPDTDAKYKGIDSKALVLLVRDLMEEMRWEVVNVDVIIHAEEPKLGAYKGQIKRCVASLLSADFNNVNIKAKTNEGLGPVGEGLAIESTVSVLLRRRLKRTLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV6</accession>
    <name>A0A1U9NIV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallophosphoesterase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01015"/>
    <dbReference type="EnsemblBacteria" id="AQT67863">
        <property type="protein sequence ID" value="AQT67863"/>
        <property type="gene ID" value="STSP2_01015"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01015"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="80"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="301" mass="32716" checksum="26B21771194A6B0B" modified="2017-06-07" version="1">MLFAGGILLVFWAEISLLVRAWLKRGKGGWQSLVNRYAVLVHVVFLVTAGCLVWGYWVEPYWLDVSEVRVKAGELADSSLRVVHFSDLHCDPVERCEEELVAAVNAADADIVVFTGDMLNPAAGDVGHAEAEELFRRTMGAIEAKAGKFAVSGNWEWRNDAEGLLEGTGFVLLDGERQMIEKDGAEVCVTGLGYGDRPGSVEVAEGAYNILLYHTPDLVESVEGFDLYLCGHTHGGQVALPWYGALITFSEFGKKYEAGRYEVGGMDVYVSRGIGMEGGGAPRVRFCARPEVTVFEIGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV7</accession>
    <name>A0A1U9NIV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00826"/>
    <dbReference type="EnsemblBacteria" id="AQT67678">
        <property type="protein sequence ID" value="AQT67678"/>
        <property type="gene ID" value="STSP2_00826"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00826"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="71"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="75"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="43251" checksum="C3E09BC95C6E64CE" modified="2017-06-07" version="1" precursor="true">MTSFKPRTVSISVIILLITTIAGCARSRSPLPVDRVADGQIPGFNAIRYWEAQHKPPINPNSKYSSGCNILALSGGGSKGAFGAGYLNGWSDTGTRPQFNIVTGISTGALIAPLAFLGPEYDEELAISYTTVETKDILRARGLLGNGILPLLFSESYATTKPLQRMIDGLLTPEVFRAIAAEHAKGRRLYIGTTNIDAQRMMVWDMGAIASSDHPDARKLFEKVMLASASIPGAFPPVLFEVQIDGKLYDEMHVDGGVITGVIGYGSSLQKGLDTNAACNLYVIKNGKLDVEHAQVKRKALPIMKRSIATIMKAQAWSSMIRLRNIAKQDNVTFRYISLPENFEQKGEEMFDPKDMKRMYDLGYSIATSDKPWQKEVPLFKEDEKWLWTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH0</accession>
    <name>A0A1U9NJH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01117"/>
    <dbReference type="EnsemblBacteria" id="AQT67965">
        <property type="protein sequence ID" value="AQT67965"/>
        <property type="gene ID" value="STSP2_01117"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01117"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021322">
        <property type="entry name" value="DUF2924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11149">
        <property type="entry name" value="DUF2924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="19450" checksum="4A0956BDDE561012" modified="2017-06-07" version="1">MKIDVARCRDELDGLSIDQLRMRYEKVFGEVSTSRHRTFLIKRILWKMQANVYGGLSYKALKRASELADPTELRMIAPSSPPPPRDGRKVSRSLPARVTSNQSDLVPGTQLERMYKGQRILVTIMDNGVRWNGELYRSLSAVAKEVTGTHWNGKLFFGITKKKVKNAKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR0</accession>
    <name>A0A1U9NJR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inner membrane protein YnbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ynbA</name>
        <name evidence="2" type="ORF">STSP2_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01201"/>
    <dbReference type="EnsemblBacteria" id="AQT68047">
        <property type="protein sequence ID" value="AQT68047"/>
        <property type="gene ID" value="STSP2_01201"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01201"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21927" checksum="4C83757A1E6DCA13" modified="2017-06-07" version="1">MPSIYDIKPAFQNLLRPITNSLARIGITPNQVTTAAAVLSIAVGLAIYRWHENRLVLLALPIFLFIRMALNAIDGMLAREHDMKSDLGAFLNELGDVISDTALYLPFAAIPHFNPILVIVLVLLAALTEMTGVVAVQIKASRRYEGPMGKSDRAFVFGIIGLVLAVGVPTGAWCSIILWIILAALILTICNRIRKALQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS4</accession>
    <name>A0A1U9NJS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67830">
        <property type="protein sequence ID" value="AQT67830"/>
        <property type="gene ID" value="STSP2_00981"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00981"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012098004" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11368" checksum="E03FED11E5887865" modified="2017-06-07" version="1" precursor="true">MNLISRKAVLVHVLAVICLALTLAGCDNDTDIRHSKRAPSTITGSFDVYYSIQTSETSTMGTGDTPSKATAIHFYDEYIVVEESKSSEILPINKIISFRWTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV6</accession>
    <name>A0A1U9NJV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68223">
        <property type="protein sequence ID" value="AQT68223"/>
        <property type="gene ID" value="STSP2_01379"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01379"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="485" mass="57061" checksum="A1A007A9C121C0BF" modified="2017-06-07" version="1">MSKRETPPRKKVGRNWYVCDRQGKIVEGLAYDTGNGYYFYSGWRQEPGVKQKKKTRKDYQFGRDYDEAIYLFRQWQEKDKSFSPINYDSVMENGGLIHTPDDAPKGSEIVEEYDEDGFLSAYAIQHEIDDDEVWRRARSLILQDIREAAKKLGFPCLLEIEDKLLKHREIPKLTIQNIRDFFWDHNGSKPQEKRMVRLAINEFMEYVKDSDVSSMDKFDVMAWNEFLHSDGHSSNFINKRIERVITCLNFYLKNFEKKKRQENQHKAEIKRTVDLIKEHTDKKSAQIKDTPKTFSVKTLKKLFKKINNDRQFVLINLLALNCGFYAKDIEGIKKDMVREKDGLTFISYPRDKTQKTSPRVIVLWEKTTSLLQDYMNDNPNNTDYVFLNKAGTNLKVPSIQKKFRQYKAKVKNEDKTDINFKSYRDTVASSLVYKVDNTDLITVTLGHDFGGKKKMYWKYIETNPSEIKVVADILYDKFKAVIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY4</accession>
    <name>A0A1U9NJY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction enzyme EcoKI specificity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdS</name>
        <name evidence="6" type="ORF">STSP2_01387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01387"/>
    <dbReference type="REBASE" id="190998">
        <property type="entry name" value="S.PbaBD1II"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68231">
        <property type="protein sequence ID" value="AQT68231"/>
        <property type="gene ID" value="STSP2_01387"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01387"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="56"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="333"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="488" mass="54469" checksum="480244493C298BCD" modified="2017-06-07" version="1">MGKQKQSKGLPKGWVYATIPNIVANGGVFSDGDWVESKDQDPDGDVRLIQLADVGDGCFKNKSSRFLTEQKFKKLNCTQILPGDVLIARMPDPLGRACIFPGDKKKSVTVVDVCIVRTSQNGPEHRWLVHTINAPQFRRDVALYQSGSTRKRISRKNLAKVQFPLPPLGEQGRIVGKIEELFSDLDAGVAALEKVRGELKRYRQSVLKHAFEGKLTAKWREENKDRIEPADKLLERIANEREKNAKGKKREKLPPLDTSKLPELPEGWVWSRGDDVFYFITSGSRGWAKYYSETGKLFLRMGNLDHDSISLDLSDIQLVQPPSGAEGIRTRVQPDDILISVTADVGMTALVPKSISEAYVNQHVALARSVDSIEKRFLAWFIASSDGGQRQFALLRRGATKAGLGLDDIKTIGIPLASLAEQGQIVAEIEKHFSIADKAEQMVEDALKQSGRLRQSILKKAFEGKLVPQDPNDEPAEKLLERIRKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY8</accession>
    <name>A0A1U9NJY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68058">
        <property type="protein sequence ID" value="AQT68058"/>
        <property type="gene ID" value="STSP2_01213"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01213"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="566" mass="62624" checksum="51B5D00BF93A9378" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK11</accession>
    <name>A0A1U9NK11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68147">
        <property type="protein sequence ID" value="AQT68147"/>
        <property type="gene ID" value="STSP2_01302"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01302"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7088" checksum="C7351A65635444B9" modified="2017-06-07" version="1">MPLRYGDTKFGHESWVDKVEGAADRCVQMFCNERLWEAVALVEIGLVTMTVLALGVGWAVSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK73</accession>
    <name>A0A1U9NK73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68309">
        <property type="protein sequence ID" value="AQT68309"/>
        <property type="gene ID" value="STSP2_01468"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01468"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="305" mass="33807" checksum="335F4E5217DF1EF3" modified="2017-06-07" version="1">MGKLDHIRIPREVLKFGLKGSHEICIMGLIYSFGRNGLMLTDMQLANFLHTSSRTVERALKKLRDRGFVVSKRAAGCRRRLVVGPAVESVHNAGSAPDALGQSGSDMDPGVTDPRSGGWPVSSPDILSVNTDVTAGFNPTSMGDETDVTAGQKESNKMKVEEESSAGRNSHNRAFVDYWNAKENLPVIRAFSDQRQNRLKVRMSERVFADNWREAIDKLSASSFATGHNDRAWRADVDWLLKNSTNYIKVLEGKYDDRDLPGPVKGAGDTKQEFTPEMEEAFLAENTRTITDSEAKKLFEEIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE5</accession>
    <name>A0A1U9NKE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01215"/>
    <dbReference type="EnsemblBacteria" id="AQT68060">
        <property type="protein sequence ID" value="AQT68060"/>
        <property type="gene ID" value="STSP2_01215"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01215"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341564" evidence="2">
        <location>
            <begin position="23"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="658" mass="70113" checksum="A3546696D7A6E303" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI0</accession>
    <name>A0A1U9NKI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="1">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hcpC_2</name>
        <name evidence="1" type="ORF">STSP2_01569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68409">
        <property type="protein sequence ID" value="AQT68409"/>
        <property type="gene ID" value="STSP2_01569"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01569"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36045" checksum="F44D2FC33ED4698A" modified="2017-06-07" version="1">MAKKNNDRKIESLKKTADHGNMYAQYELANAYFFGRGAPQDHETALKYYRLAAKQNLPEAQYMVGHCYYHGLGTRKSYKTALNWFEKAAGRGNPQAHGYIGEAYKYGNGVPQDRAKALPHFKVAAKAGDSIAQVDLAYSLWEGIGTRKNRPQSINWYRQAAHQNNERGQFNLGLCYLFGEGVRKDIKTAFKWFHLAAENGHPRSMFWVGHAYLTGQGTRKNSSLAFKWFLKAAVADDSRGQTYLGMCYHDGIGVDTDLEEAVHWYRLAAAQDEPFAQYCLGLSYLDGDGVKPNKTTARKWITKAAQNGDPLAQKELDHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS8</accession>
    <name>A0A1U9NKS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA modification/repair radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01567"/>
    <dbReference type="EnsemblBacteria" id="AQT68407">
        <property type="protein sequence ID" value="AQT68407"/>
        <property type="gene ID" value="STSP2_01567"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01567"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="65"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="42384" checksum="A9C64F45F3414C53" modified="2017-06-07" version="1">MTAIISRPDTLKKLEILSADAQYDLACACSGKDDDKRVRGSEGKWIYPVSLPNGGKSVLFKTLMSNACGNDCRYCPLREDMDLRRVSLGPEETARVFMEYWRRGKVFGMFLSSGVCGSPDATMDRLNATAKILRAKHGFRGFIHLKVIPGASAGAIREAVSLASAVSLNIETPGAGKLAKLSGKKDFMRDIVEPIKMISRLTAKGERYARVKQTTQFIVGAAGESDAEIVKYMGGMYDRLKMHRIFFSAYQKGLGHEAMPGEQAEVQRAEDTFTREHRLYQVDFLLRKYGFKDEDIVYGEGGQLSLDADPKEVWAEAHPEFFPLDVNRARRKDLLRVPGLGPVTVRRIMKMRKEGKIGRIEDVGKVGKLLGKAEGFLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT8</accession>
    <name>A0A1U9NKT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01577"/>
    <dbReference type="EnsemblBacteria" id="AQT68417">
        <property type="protein sequence ID" value="AQT68417"/>
        <property type="gene ID" value="STSP2_01577"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01577"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21814" checksum="4C6619C75F328671" modified="2017-06-07" version="1">MDKNQLRMQIKRAMLDMDDQKRAQLSKKACQNLINTDDFKKAAVIMVYLSLPHEVDTTFIILQAWQQNKTVAVPKVSWQQRHMIPVEINSLESGLSVERHGLRNPSTGLPMPLEDIDLVVTPALAFDRHGHRLGRGGSYFDRFFQSPRLKAKKCGLAFSGQLLDEVPQDEHDVPVDCIVTDEGVIDCSSLTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU0</accession>
    <name>A0A1U9NKU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component PulK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68529">
        <property type="protein sequence ID" value="AQT68529"/>
        <property type="gene ID" value="STSP2_01694"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01694"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111583" checksum="271A7E5242D0CB97" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL04</accession>
    <name>A0A1U9NL04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68589">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="23695" checksum="1413C0B73970F90C" modified="2017-06-07" version="1">MNSESVKIRAFAALVPYPVIICGCYYFDNSWATVLIYHLWLLTCLLLFRRDIFGKVLKGWNCKVFLALAAVGLASGLAIVVVWPLARSEDVELASLLNRLSIGGHWRFVFVVYSIAVNPLLEETFWRGFIDGPSKWPNWADAAFAGYHVPVAMMAIDFLWCVPLFFTLMFAAYLYRQTYLHLGGLALPYLSHLIADISISTAISWIAYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL26</accession>
    <name>A0A1U9NL26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01690"/>
    <dbReference type="EnsemblBacteria" id="AQT68525">
        <property type="protein sequence ID" value="AQT68525"/>
        <property type="gene ID" value="STSP2_01690"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01690"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32875" checksum="1915BDE4A6C29017" modified="2017-06-07" version="1">MFARRNNKRNVGFTLVEMLVTIGIIAVVIGMLVPALSMVRDTANRVKQKAQFSTLEVGLEAFKNDFGDYPPDVLVGGDVSGTYEYTSYTGAQRLAEAIIGQDGFGVNTGSSFNGDMSFYGMYTDPVTDEQRPIGTRQGPYVEIENANATRLSAIYPDTALTSTSLNPATFVLSDEYGLVKSRISGEQTGMPVLYYKANTSKFGHSELGTTDYLYYNTDKNVYNPICNRVIYGLGSAPSVQGANMLNGPGTFWDYFLKKIENPNFSTNSRPYRAQSFILHSAGADGRYGTSDDIYNFDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL35</accession>
    <name>A0A1U9NL35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01809"/>
    <dbReference type="EnsemblBacteria" id="AQT68641">
        <property type="protein sequence ID" value="AQT68641"/>
        <property type="gene ID" value="STSP2_01809"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01809"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="30506" checksum="3F0B961924005C60" modified="2017-06-07" version="1">MKTAKTIAIASGKGGTGKTTVSTNLAWTAADRFKSAYLDCDVEEPNGGIFLKPAIEASKTVHVDVPQVDISKCSGCGKCGRLCQYSAIAHLGGQNVITFENMCHSCGGCMRICPTGAITAKKMEIGTVSHGSAGKLRFAGGLLKLGSVRTPSLIHEVLAGDTDAELRFVDAPPGTSCPVIAAVRGADYVILVTEPTPFGLNDLRLAVDMCRALRLDCGLVINNAYGEYVPLDEYVDEQELEVLGRIEYDRKIAEAYSRGEMIVDSLPTYGKVFGRILDRVLEHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL79</accession>
    <name>A0A1U9NL79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68693">
        <property type="protein sequence ID" value="AQT68693"/>
        <property type="gene ID" value="STSP2_01865"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01865"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="187"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="46891" checksum="F8010177EA4B47F5" modified="2017-06-07" version="1">MATEKIGIYRRWLEPAPTENGRKIPKSDWPKNRRHNWVVRWFGTDRKRYSKSFKTRKQADNFARQLQEQVNCGKQDRPKRIAFEDFVAEHKILTKGQVADATLVEQMHKLKLFKKFIGGNTLLTEIRARDAEAFIAKRLASGISTATANKDIRTLKSIFNLAIERRGYLKEGDNPFAKIKQRRISSKPINYVSMDDYRKLLHTTDSLWWKTFISAAYCCGLRRGELVNLTWNDIDFENQYIYVNPKKHMEHTIEWEPKDHERRVIPMPEKTAQLFADIHFESTGCAPYVFLSPERLRHIKQRIDRGTWNSKCEVINNLPKKFNTLCKKAKICEYSIHDLRRSAITNWAQHLPIQIVQQFAGHSNITTTRQYYLAVCPENLASASKLMNKMLQKGFSGLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL84</accession>
    <name>A0A1U9NL84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68702">
        <property type="protein sequence ID" value="AQT68702"/>
        <property type="gene ID" value="STSP2_01874"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01874"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17930" checksum="B8B35DBA882962D5" modified="2017-06-07" version="1">MSEKEKYSVSKTAKLLGFSRARFYELLDQGVFPRPFRDPANNRPYYDNELVQKCQAIKETCVDIEGRPVVFYKNKKTTTSEDSKDAKKELSNRHTEIYHIVKAMGVECSYAQFAEVCNQLLPNRGDDISRAAAIKNIYRHLCRNKKVPDNFKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB0</accession>
    <name>A0A1U9NLB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur carrier protein ThiS adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiF</name>
        <name evidence="2" type="ORF">STSP2_01893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.73" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01893"/>
    <dbReference type="EnsemblBacteria" id="AQT68721">
        <property type="protein sequence ID" value="AQT68721"/>
        <property type="gene ID" value="STSP2_01893"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01893"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23882" checksum="BBF4C786E1CCB2AF" modified="2017-06-07" version="1">MNPRYSRQQDIVPAERIASCRATVIGVGAIGRQVALQLAAMGIPWLQLIDHDLIEVTNIASQGYFEADLGKPKVRATAGLCRQINSKLEVVSVEQRFKRSGEIGNCVFCAVDSIHTRRLIWQAVKDRSTFFVDGRMTAESLRVITAADESSRLHYPRTLFTPQRAYAGACTAKTTIYCANIAAGFMLAQFTKFLRQMPAEADIQLNLLAAEISVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC4</accession>
    <name>A0A1U9NLC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor CnrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnrH_3</name>
        <name evidence="4" type="ORF">STSP2_01914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68742">
        <property type="protein sequence ID" value="AQT68742"/>
        <property type="gene ID" value="STSP2_01914"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01914"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="20809" checksum="86220AEE7E60C0DA" modified="2017-06-07" version="1">MGNKRTENLRTESFLECLLPAQSTIRSYIATLVPIASDVDDIYQETITIAWRKFDEFEPGTDFAAWAVKIAFYRILNYRRSRAKQHLQFKDEIFEQFAEVASRNAARTHESIAALNNCIEKLPESERKLLNLRYTQNIPIKSIAERCGRTANYIYRSFSRIHCKLQRCIKQTLPQEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG5</accession>
    <name>A0A1U9NLG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapF</name>
        <name evidence="10" type="ORF">STSP2_01570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01570"/>
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        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
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        <property type="term" value="F:diaminopimelate epimerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
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    <feature type="region of interest" description="Substrate binding" evidence="8">
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            <end position="227"/>
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            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
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        <location>
            <position position="11"/>
        </location>
        <ligand>
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            <position position="62"/>
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        <location>
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        <ligand>
            <name>substrate</name>
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            <position position="176"/>
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    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
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            <position position="226"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000189674"/>
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    <sequence length="292" mass="31726" checksum="D2F445A825F92E8E" modified="2017-06-07" version="1">MKFTKMHGLGNDYVYVNCFEEKVENPEEVAVKISDRHFGVGADGLILICPSDVADVRMRMFNSDGSEAQMCGNGIRCVAKYTFDHGLARGDSEFSVPGQETFKNSLRVETGRGILKLGLAVGDDGKVEKVCVNMGQPILKGEDIPVALNLDEVIEEPIEVEGDVLRMTCVGMGNPHAVFFVDEGVNSIVLPKIGPKVENHDLFPERVNGHWVEVHAPDEFTMVTWERGSGITMACGTGACACGVAGVLTGKTERVTKAHLPGGDLELNWCEEDNCVYMTGPATEVFTGEWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK4</accession>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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            <begin position="1"/>
            <end position="23"/>
        </location>
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            <end position="1022"/>
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            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1022" mass="111146" checksum="7D53F849380062C4" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN0</accession>
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        <submittedName>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="690" mass="77571" checksum="DFB0C46FDE84B4C8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP5</accession>
    <name>A0A1U9NLP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">argG</name>
        <name evidence="11" type="ORF">STSP2_02005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02005"/>
    <dbReference type="EnsemblBacteria" id="AQT68829">
        <property type="protein sequence ID" value="AQT68829"/>
        <property type="gene ID" value="STSP2_02005"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02005"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
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        <location>
            <position position="118"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
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        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
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        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
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        <location>
            <position position="276"/>
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        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48317" checksum="32E61E29C0B4D60D" modified="2017-06-07" version="1">MAKKEKIVLAYSGGLDTSVILPWLKETYGYEVIAYAADVGQGAELKGIKQKARKTGAKKTYVEDLRKEFVEDYVWPTLKSGAIYENEYLLGTSIARPLIAKRQVEIAQAEGATAVAHGATGKGNDQVRFELTFMALDPSLKIVAPWKDSNFTMRSREAAIDYAKERNIPIDQSKKKIYSRDRNLWHISHEGADLEDPWNEPKDDLFVMSNPISKTPNKADYVEIGFEQGIPVKLNGRAINGVTMIERLNDIGGKHGVGQADLVENRLVGIKSRGVYETPGGTILVQAHKFLEMLTLDRETTHYKQQIALKYADLVYDGQWFSPLREALDAFVDQTQKNVTGTVKLKLFKGRCTLAGMKSPKSLYSSDLASFTMGAEYDSTDATGFIKLFGLPMKVSGVVDRQTSGKTSGRRTRKTAKKKTARRKTTKRTTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP9</accession>
    <name>A0A1U9NLP9_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1936003.STSP2_01665"/>
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        <property type="protein sequence ID" value="AQT68500"/>
        <property type="gene ID" value="STSP2_01665"/>
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    <dbReference type="KEGG" id="alus:STSP2_01665"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5013228233" evidence="2">
        <location>
            <begin position="23"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="327"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="679" mass="72424" checksum="D381D3269879C6A2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ4</accession>
    <name>A0A1U9NLQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_02015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68839">
        <property type="protein sequence ID" value="AQT68839"/>
        <property type="gene ID" value="STSP2_02015"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02015"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="385"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="493" mass="56076" checksum="59E3BC6012C2A7D4" modified="2017-06-07" version="1" precursor="true">MGISRRNFLKNVGMSLAACTLTGTAARALGEEPKKNTKPNVLFIFADDQTYECVRALGNDEIKTPNLDRLVNEGTTFTHAYNMGAWHGAVCVASRTMLNTGRHLWDAREKEKSLNSEAEKGHFWSQYMQRAGYDTYFSGKWHVKTDVNQLFDTVSHVRPGMPRSVNQAYNRPVEGEEDKWKPWDKKFGGYWQGGKHWSEVLGDDGVKFLDKAAEKEDPFFMYLAFNAPHDPRQSPKEYVDKYPLLDVKLPENFLPEYPHKDAMGCGKWLRDEKLAPFPRTEYSVKVHRQEYYAIIDHMDAQVGRILDKLEETGQKDNTYIFFTADHGLSCGHHGLMGKQNMYDHSVRVPLMVVGPGIPASKKLETPVYLQDIMPTTLELAGVEKPEQVAFNSLLPLVSGEKKSSYDAVYGGYMNLQRMITKDGFKMILYPKISKVLLFDLESDPLETTNLADMEKYGKTVAKLSKSMAKLQKSMQDPLDLSEAYSELFTPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT5</accession>
    <name>A0A1U9NLT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68767">
        <property type="protein sequence ID" value="AQT68767"/>
        <property type="gene ID" value="STSP2_01939"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01939"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="537"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="857"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1418" mass="153362" checksum="7E74FDEE5A073630" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU4</accession>
    <name>A0A1U9NLU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68708">
        <property type="protein sequence ID" value="AQT68708"/>
        <property type="gene ID" value="STSP2_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01880"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="133" mass="15005" checksum="AC193F552D66C88B" modified="2017-06-07" version="1">MSNNPLNINIVGKELVDYSRHILPSGKEVYFLVYEITHTDAQGLCRTYKDRVTFPPLDGGIQPESPEDVRECSECEGLFTASQTVSCHDCGRILCMQDAALTEENEERIPLCPEHAAKRNNPIVRFFNSLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW0</accession>
    <name>A0A1U9NLW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68787">
        <property type="protein sequence ID" value="AQT68787"/>
        <property type="gene ID" value="STSP2_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01960"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13557" checksum="1B77C011B7ACDEAA" modified="2017-06-07" version="1">MWLCTRYGFFSVVRGNDRISPGKVMVRARKAGHLRNLQGRFAELRDVPLKTSSTTDYPCRLVVDREVWARIGAELAADIDYTNFKNAAGDELAGDSDYSEFLHEVWWKGMQLLQRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ5</accession>
    <name>A0A1U9NLZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01671"/>
    <dbReference type="EnsemblBacteria" id="AQT68506">
        <property type="protein sequence ID" value="AQT68506"/>
        <property type="gene ID" value="STSP2_01671"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01671"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="26276" checksum="4F62935D085D76AF" modified="2017-06-07" version="1">MTKKEFTGNKKAPMKSLLAKPEKRFVDFLTPRFPRFLETYHLTLMTIPWSAGVIIFGYLAGTFSHLWLHLSSFMLFLQWFTDAFDGAIGRYRDTGLLKWGFYMDHFLDFVFMSAVFIGWTFLFEGTNNLLMWFLVPAIGCLMVNSFLAFGATGEFKITYLRTGPTELRLAFIIINTIIAFAGTELISVALPYIFALFWLGVVLVVYRTQKHIWKLDMQHKANNAKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM35</accession>
    <name>A0A1U9NM35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LL-diaminopimelate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dapL</name>
        <name evidence="7" type="ORF">STSP2_02190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02190"/>
    <dbReference type="EnsemblBacteria" id="AQT69012">
        <property type="protein sequence ID" value="AQT69012"/>
        <property type="gene ID" value="STSP2_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02190"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="35"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="44873" checksum="B3647C018AA259C3" modified="2017-06-07" version="1">MIKINENYLKLQAGYLFPEIGRRVSEFAENNPDADIIKLGIGDVTEPLCPAVIKAMHDAVDEMATSEGFHGYGPEQGYEFLTEAILANDFAPRGVKLDKSEIFISDGSKCDTGNIQEIFGLDNIVAVTDPVYPVYVDTNVMAGRTSNATEGGRYGGIVYMPCTAENNFVPELPSESVDMIYLCYPNNPTGATATKDQLKKWVDYARENKALILFDAAYEAFISDPNIPHSIYEIDGAEEVAIEFRSFSKTAGFTGTRCAFTVVPKALKAYTKAGEAIDVNAIWNRRHSTKFNGCSYITQKGAAAVYTPEGKEQIRNTINLYMDNASRIRKALTELGYNVYGGQNAPYVWLQAPEGMKSWEFFDAVLNKAHVVGTPGAGFGAAGEGYFRLSAFNKPEIVDEAMKRFAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM76</accession>
    <name>A0A1U9NM76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose metabolism transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR_2</name>
        <name evidence="2" type="ORF">STSP2_02112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68935">
        <property type="protein sequence ID" value="AQT68935"/>
        <property type="gene ID" value="STSP2_02112"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02112"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="42431" checksum="F9CF3028D109BAC2" modified="2017-06-07" version="1">MNTPDISAANEKTKHRQIYEYLHKAIVQGRYKNGERLPSEVDLAKKFKTSRPTVARSLSDLHQSGLIVRKVGSGTYVKFKGELCGAKTFGLMVPGLGETEIFEPITAYMSYIAEKNNLSLLWGRSVSEDAEARKKHARRLAERFIQQEVDGVFFAPLELTSEKDAVNTRILQWFEEAHIPVVLLDRDVVPFPQRSRYDLVGIDNFHIGSVLTEHMIECGYERVEFLSRPFSAPTVDMRIIAFQQMLRHAGMEPNADSVRWAQPEDIEFIRSITSDACKKAFICANDATAAILMHTLDQLQINIPDEIGVAGVDDIRYASHLRVPLTTYRQPFEELANVAVETMLARIASPAMPVRSTYLRGELVVRQSTMPTSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM86</accession>
    <name>A0A1U9NM86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylesterase</fullName>
            <ecNumber evidence="3">3.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68945">
        <property type="protein sequence ID" value="AQT68945"/>
        <property type="gene ID" value="STSP2_02122"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02122"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008265">
        <property type="entry name" value="Lipase_GDSL_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01098">
        <property type="entry name" value="LIPASE_GDSL_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="127"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="32238" checksum="956B06D1C1E74476" modified="2017-06-07" version="1">MTADSLPDIFWLLAGGAGLYIGTALMAIAAATVMINSSLAGRLVGLLLFSIGGTSVIISATPLPTWTYAAAIIFALPWLTLVIVGTRRRQKFSCILLLLTASALTACDLPFYLMPDIQGTGYDRLVVVGDSLSAGMGHKNIKTWPSLIAERHGIHTENRAVAGATVGSALKRQTAGSDLQNSLVLLEIGGNDTFLDTPKDAFERDLEALIRHLQKPSNLLIMLELPIMPTDLEYGRIQRRLASELNVTLVPKRYLVNVLSTQGNTLDLAHLTQQGHEQMARMVWELVGDAVIQPAKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH8</accession>
    <name>A0A1U9NMH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68800">
        <property type="protein sequence ID" value="AQT68800"/>
        <property type="gene ID" value="STSP2_01973"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012934048" evidence="1">
        <location>
            <begin position="22"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="305" mass="31757" checksum="024A3F67EDD56BCD" modified="2017-06-07" version="1" precursor="true">MRKLFGVVILMSFVSIGSVFAAPLLVSGDMTITEGNAIEEINAYGQANITITGGEVSKIILAQDANLDMQGGTVSTLKTFDNSTANITGGTTNYLETYCSSEVIVDNGLESSTVPTISSAKFESGICKINGGTVGEVTLGASVEVFVSGGTVNGIKRWDPIVGNPAVVILGGTLGSIDMYTGRVTCKGGQIDSLGISSIAKAEIHAGGINGLTGIPKLIEGYTFVVDDASKLPFGGDDNQPHIWGTYKNGQQFDISLPDIIYDSVQFTTKAVCTNQPDADLTGDCVVNTSDLAVFASEWLDSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML7</accession>
    <name>A0A1U9NML7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02145"/>
    <dbReference type="EnsemblBacteria" id="AQT68968">
        <property type="protein sequence ID" value="AQT68968"/>
        <property type="gene ID" value="STSP2_02145"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02145"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29596" checksum="3A432C3E4B18F6E2" modified="2017-06-07" version="1">MKKRGFTLIELLVVISIIALLLAIMMPALGMVKEKARAVVCRSNMKQWGLCVALYAQNNNGKLQDGRTGYEEGGEGASVWYHAYRDYYNDPDIRFCPSAKKLGKVPHGNAGIGYWGGKYEAWSLNNATDDSGSIAMNSWAMSPTYGDTSYYWKKFHCKGAKDVPVFVDGLWRSLNPKNIDTAPASDGALPPAAWQDSMWRVALDRHDGAVNVAFMDGSVSKVDIKELWSLKWSRVWDTDEGPNGGWPEWMDKFKDYDYPGLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP3</accession>
    <name>A0A1U9NMP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69183">
        <property type="protein sequence ID" value="AQT69183"/>
        <property type="gene ID" value="STSP2_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02370"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="28442" checksum="E8D3C688759D5B20" modified="2017-06-07" version="1" precursor="true">MKKAFTLIELLVVISIIALLLAVMMPALGKVKANAKKVICATNIRQNGQAFALYAADNDGKLYVGPGGPMSSFYSWGGVTMDWDYGYLPGSWNKDTNPYERALNKYLPEDNPVYICPSDPKGDSKLFAPFGTDREPRHNGQAYYTTTGTSYQYNAFLTSVSKYTKMSQVRRASNTPLVFEWPVYDVVRDALRPANWTDKPRWSFHDNSGRGTEPRDVDENGNNTCFVDGHTEYITYVKGKEATAEYDLYDGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ4</accession>
    <name>A0A1U9NMQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">STSP2_02186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02186"/>
    <dbReference type="EnsemblBacteria" id="AQT69008">
        <property type="protein sequence ID" value="AQT69008"/>
        <property type="gene ID" value="STSP2_02186"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02186"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="37235" checksum="16CA349DBCA2F8FC" modified="2017-06-07" version="1">MQPELFEIPFIHVTLKSYGLMMVIGFLVAMFVMRRMAAHQGEDPANILNVALYSLLAGVIGARLFYVVHHAENIDSFGEIFAVWQGGLEFLGGVLFAAAVVGSYLWFKKLNARKYGDMIAVGLMIGLAFGRIGCFLNGCCFGAITENPLGVQFPYGSPPYQSQAYPDSDRQRDEAVLDLPPEYYGGFDEHGHWVPAQSDAQKHHYYLKPKEKLTEQQQEAVKNVYSCRPVHPTQLYASANGLLLAGVLFLFWRRFRDAKPGWTFSLMLILYGTTRFVLESIRADNPFEYGWWALYKGGTVSQNIGIYMVITGLVLFYVFNRMSRSSRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV2</accession>
    <name>A0A1U9NMV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylE_2</name>
        <name evidence="8" type="ORF">STSP2_02107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68930">
        <property type="protein sequence ID" value="AQT68930"/>
        <property type="gene ID" value="STSP2_02107"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02107"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="485" mass="52473" checksum="E4ED2BC3F3C56AB8" modified="2017-06-07" version="1">MKVNGILLRSSIVAALGGLLFGFDTAVISGTVDHLEKVFQVEGFWLGFTVASALIGTIFGAMFAGNPADRFGRRNTLFILALLYFVSALGSAFAWNWWSFIIFRFIGGLGVGGSSVVAPMYIAEISPAKLRGRLVAVVQFNIVLGILLAFLSNYIVAALVADAVEWRWMFGVEAVPAAAYFFLLFGNPLSPRWLVGQGKSDKARGVLESIGVDEGKSTEDELRDIQVSLERENMQEKEGFLTFKWEQGMNPKYAIPVMLAVLIAMFNQLSGINAVLYYAPNVFKLAGADRNASLLSSVGLGLTNLIFTMLAMLVIDRFGRKKLMLVGSIGYIISLAAVAVTFHMNGNFSAAAETATGVTTSSVIVLVSLAVFIASHAFGQGAVIWVFISEIFPNKVRAKGQSLGALTHWIMAAVISWTFPMFADTLGGTATFSFYGGMMVLQLLWVLFIMPETKDVPLEQIEQKLGIVSAEQTSSAASEPDELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW1</accession>
    <name>A0A1U9NMW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylR_4</name>
        <name evidence="2" type="ORF">STSP2_02324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69137">
        <property type="protein sequence ID" value="AQT69137"/>
        <property type="gene ID" value="STSP2_02324"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02324"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="42323" checksum="59CC864FB2EA5599" modified="2017-06-07" version="1">MKKVLIIVDTSRNTGRQLLAGAEKYITAFARWQVQTKPPEYLESSSEDIYDLDSFDGFFICDAKNISRILQTDKPKVINYIHESGSAGATSIVTNSDLIGRMAADYFYSLGFRNFAYCGFDNIPWSEKRLRSYESQVSSYGIEKVFTFNNSSGLGKKKPVIEWLQSLPKPVCIFGCNDDRAIYIMEACKVGGISVPEEVAVLGVDNDELVCNLSSPPLSSILLSFETAGFAGARQLEELMQGQASNEAIIVEPVEIIERQSTEMLAIEDKEVVSALVYIRNNFHKPIQASDVVNATAVSRRSLEYRFKNQLDRTIKQEIDRFRVNYIKKSLNKTDLPVYKIAASLEFTDGEHFSRYFKNLTGQSPMQFRRSLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN13</accession>
    <name>A0A1U9NN13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PhoD-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02521"/>
    <dbReference type="EnsemblBacteria" id="AQT69332">
        <property type="protein sequence ID" value="AQT69332"/>
        <property type="gene ID" value="STSP2_02521"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02521"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301698" evidence="1">
        <location>
            <begin position="23"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="402"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="863" mass="95446" checksum="88C24190D1C5887F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN27</accession>
    <name>A0A1U9NN27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">panC</name>
        <name evidence="6" type="ORF">STSP2_02188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02188"/>
    <dbReference type="EnsemblBacteria" id="AQT69010">
        <property type="protein sequence ID" value="AQT69010"/>
        <property type="gene ID" value="STSP2_02188"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02188"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31679" checksum="A5C99D8B50845DEF" modified="2017-06-07" version="1">MRTLTTIEEMRAFVRDARSQGKSIGFVPTMGALHAGHLSLIRRAKEKSDVVVVSIFVNPTQFGPSEDLEAYPRDMAADQQKCRDEQVDAIFAPAVNEMYPQENLTWVNVESLTDKLCGRSRPGHFRGVTTVCTKLFNIVQPDYAFFGQKDGQQAIVIKRMVADLNMPLQIVVCDTVREPDGLAMSSRNKYLTPEQRQDAPLIYKSLAAARDAVDQGERSTEKVKQTIQSVLAESQEIEPEYINIVDLDTLSELPQIQGKALIAIAAKLGTARLIDNIIVDANTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN92</accession>
    <name>A0A1U9NN92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PA14 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02494"/>
    <dbReference type="EnsemblBacteria" id="AQT69305">
        <property type="protein sequence ID" value="AQT69305"/>
        <property type="gene ID" value="STSP2_02494"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02494"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029031">
        <property type="entry name" value="Gingipain_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956674" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="791"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120524" checksum="D182DC06367A303A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND2</accession>
    <name>A0A1U9NND2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Magnesium transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">STSP2_02524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02524"/>
    <dbReference type="EnsemblBacteria" id="AQT69335">
        <property type="protein sequence ID" value="AQT69335"/>
        <property type="gene ID" value="STSP2_02524"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02524"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
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        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
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        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
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        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00924">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54159" checksum="7D589CF4C6570DB1" modified="2017-06-07" version="1">MAENEQKQFVEQVQGMLEYELQQDLSTLLEEHRSSEIAEVVELFDTERRLKLLDLLDIETAADVVVKVDEATRHELFCLMPEDRLIDIIAELDADDAADVLGELPEDRRAPVLSHLSFADARRIRGLMRYAEDSAGGIMDPVLVSVYEDATIKEAINKIQDSEIDEDFFTIFVVDRAGKYIGDVRIRTMLTRSETIRVKDIVETDTIHVHVDDDQEEVRNIFKKNELIVVPVLDKNDRLVGRITADRIIEVAEEEAAEDIYAMAGTDAAELQNFSVVHAAGVRMTWLLPCLAGTTITAIIGLAFRGVFSQTPEMLFIFTTAYVFVPMIAAISGNAGLQTSAIVVAGLATGDLAALELRQVFAREVRVAALVALSCGVIGCLTATLLPYMMPQLFQNTGPGSKVAVGADGEIEPDAGSDGRIGTDMSAHLRIVGAFSVAMFAAIMVATTLGLFLPFLFRKIGVDPAISSGPLVTTANDSISATIYLSLTLLLVRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF2</accession>
    <name>A0A1U9NNF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sensor histidine kinase LiaS</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">liaS</name>
        <name evidence="8" type="ORF">STSP2_02623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02623"/>
    <dbReference type="EnsemblBacteria" id="AQT69433">
        <property type="protein sequence ID" value="AQT69433"/>
        <property type="gene ID" value="STSP2_02623"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02623"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="56"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="582" mass="65439" checksum="71B05A7ABA6A1605" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH4</accession>
    <name>A0A1U9NNH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02662"/>
    <dbReference type="EnsemblBacteria" id="AQT69471">
        <property type="protein sequence ID" value="AQT69471"/>
        <property type="gene ID" value="STSP2_02662"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02662"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12218" checksum="3B55C7E907F34B76" modified="2017-06-07" version="1">MTNDKKKKVLDAVLGKKGSLNGLIDYADDAVVSKTLLDKGTGTVTLFAFAKGQALSEHSAPFDALVQIVDGQGVIIIDGEEHEVAAGEVIIMPADVPHAVKAEQKFKMLLTMIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU2</accession>
    <name>A0A1U9NNU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide export protein Wza</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02657"/>
    <dbReference type="EnsemblBacteria" id="AQT69467">
        <property type="protein sequence ID" value="AQT69467"/>
        <property type="gene ID" value="STSP2_02657"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02657"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26940" checksum="7F940C3E69A7D871" modified="2017-06-07" version="1">MKFQEMIISVILVPCLILTTGCFSSNPEDINAFLMPDQAEIAAQNYLLRPPDRIVIHCTSIPELHEQEQAIRPDGKIAFQDIGELKVAGKTPNEVSGILKDRLSKLYKLTGDIPVDVRVAEYRSAAYYVFGEVNFPGAKPFTGRDTVLSAISKSRPTGSSWSERVQIIRPSSDPEERPKIFEVNLNRMLAHGDTSKNVLLQEGDMIYVPPTILAASAEVIEEIVRPVGRAFAPVNITQTGGDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU9</accession>
    <name>A0A1U9NNU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69591">
        <property type="protein sequence ID" value="AQT69591"/>
        <property type="gene ID" value="STSP2_02784"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02784"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSC" evidence="7">
        <location>
            <begin position="80"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24105" checksum="0F305C71E17780D2" modified="2017-06-07" version="1">MKSRSGLHKQVSSIFDGTPLPVKQEQTTSETRSKSRQGSSLPLRGDGFTKPGPSTVTNNSAVYSRAQASSDPKYSTASIVMLILLAVLFVAIVYWLYLKPPETPSQILNQPAEIQTSDVAEPVQINWPEAPEWPLNMRDPMTRPAKIETAESVQDAPTELVTPQLKGIVYRSGGQASALFGQQIVYEGDSVQNHKVEKIMADRVILKNEVGEEKVVLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW6</accession>
    <name>A0A1U9NNW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component PulK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69642">
        <property type="protein sequence ID" value="AQT69642"/>
        <property type="gene ID" value="STSP2_02836"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02836"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="437" mass="49866" checksum="549B65163E5C7D8B" modified="2017-06-07" version="1">MNRSALIKSNPRQKGAALILVLLVLVLASTAVYTIGSRMSTHRHREQYVIDYQNARYAADSAMKYALATVGEMDFELRQSEYATEFWDFSDLFQLNEEEYKQLQLYLAANPELMFDKSDIYKKGTKLNDLKKSGEFKTIDEFFERADYDNPAVDPNTVTVPGPYGPEWPYVTDPMEIEIGDATVKIEIEDENAKMPIMWPTIKDEEYRRQAKDSFDIFCGYMGLSWEDVDLLEKQLDTVAEYKEFKPSTKPTATEKPVKQTSRPSQPNARDRRRNTANRSRTVTRRRSATADAGDFARLLHGSIVDLEKLAEPIDNTGDRYVAPLKYLAVWGSQKVNINTAPRHVLEAAFAFGGSPAEVTEAVIQERKQQPFKDIEDFETRMYGFSDIIRRTKPFITTQSKFFSIKVTAERGNARTVSVATVVKDDKKVSTVAQYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW9</accession>
    <name>A0A1U9NNW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma F factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02499"/>
    <dbReference type="EnsemblBacteria" id="AQT69310">
        <property type="protein sequence ID" value="AQT69310"/>
        <property type="gene ID" value="STSP2_02499"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02499"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16100" checksum="F9742D19AA1DCB27" modified="2017-06-07" version="1">MEPHSAERKKMVIPSTNDGVRSACRRLIGEVKDGNFTEEEVFAIHLALEEAVVNAAEHGNGMDPDKEVTIEWSIGREKFEIDICDCGRGFKPDEVPDPRCDENLEKPSGRGVLLMRAYMDVVEFNNWGNCVHMEKHRKGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP02</accession>
    <name>A0A1U9NP02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02768"/>
    <dbReference type="EnsemblBacteria" id="AQT69575">
        <property type="protein sequence ID" value="AQT69575"/>
        <property type="gene ID" value="STSP2_02768"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02768"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36958" checksum="803A0E54D92B1107" modified="2017-06-07" version="1">MLNIVPCESIAKKMFGFLKNKTLPIGVDLGTGHLKMAQLGTEGDNVFLQAAACEPRPADIAPGTAQWQRWVSKAVKSAISSKGFKGKSVMTAMPADDVFIDQVRIARSLANSLDQATLAKVQQKLPFDPAKAVVKYVVTENGSSSDDLDVVVMVTEREKVERNLAIYEKAGLQVRGMTVWPLAITTSYAQFFGRRESDTDTTALLLEMGAHHSNAVICRQTDLLFARSIPVGYKLLAESGPSNAETLISETNSCCRYFESVSGGSRIERLVVLAREDIDQDLCHQIADFAQKMQVSAQIGDVVQAVETRPGANSDISMPQVDWAIAYGLSLSGAKQLQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP52</accession>
    <name>A0A1U9NP52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbr</name>
        <name evidence="3" type="ORF">STSP2_02689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02689"/>
    <dbReference type="EnsemblBacteria" id="AQT69498">
        <property type="protein sequence ID" value="AQT69498"/>
        <property type="gene ID" value="STSP2_02689"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02689"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21178" checksum="4643FEAEB95D0232" modified="2017-06-07" version="1">MSLKGTRTEKNLLTAFAGESQARNRYTYFASQARKEGYRQIEAIFTETANQEKEHAKRLFKFLEGGEAEIQASFPAGVIGTTVDNLKASAAGEDYETSDMYPGFAKIADEEGFDNIADVFRNIAVAEARHRDRYLKLASSIENGSVFKQDKPVRWACRNCGYIHEGPEAPEVCPACAHPQAHFELEAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP75</accession>
    <name>A0A1U9NP75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69316">
        <property type="protein sequence ID" value="AQT69316"/>
        <property type="gene ID" value="STSP2_02505"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02505"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="15167" checksum="8D8CFFE7CCE03D7A" modified="2017-06-07" version="1">MDSDKVYKKLFPKRFVNMKLYATILLIVGCLLNPIIKEVSYFIVGYSLAVIGIFLRLEKIIKSNIVATPVTKLFNDKMQLIDDKKGWEIKAKKHSGAVRRLDLDGESIFVFTPGIVVGREKTEQSETGELKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI4</accession>
    <name>A0A1U9NPI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02848"/>
    <dbReference type="EnsemblBacteria" id="AQT69654">
        <property type="protein sequence ID" value="AQT69654"/>
        <property type="gene ID" value="STSP2_02848"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02848"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256701" evidence="1">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20074" checksum="5CD6DDD9C2AD9250" modified="2017-06-07" version="1" precursor="true">MRTFTKHLVLLVVSSMAICITGCATAPKSAESKDVLQAQAQEAIAAFKQKSPGIQRFLDESAGYAVLPKVVKGGFWLGGAYGKGIVYEGGSRIGYCDMTQATLGFTFGGEYFREIIFFRDSSDLQKFKTGEFTFSAQATAIAATSGAASKADYKDGYAVFVLADKGLMVDASIGGQKFDYLSEWQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN6</accession>
    <name>A0A1U9NPN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-alanine aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dat_2</name>
        <name evidence="1" type="ORF">STSP2_02873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02873"/>
    <dbReference type="EnsemblBacteria" id="AQT69678">
        <property type="protein sequence ID" value="AQT69678"/>
        <property type="gene ID" value="STSP2_02873"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02873"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047810">
        <property type="term" value="F:D-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="31493" checksum="303DAEA194E68D81" modified="2017-06-07" version="1">MEIAVINDKQIPLTQLDPAYLDRGTYFGDGVYEVVRSYDGRIFALDDHLARFARSMREIQITGLDLDHVRKTIRSAFAQAEIPNARIYFHVTRGSERREHAPSPDLAPNFFLTVTEIGDCSARKAAGVKVATYPDIRWKRCDIKSLNLLPNVMARMEAKKKGCDEAILVDEKGDITEGAGSAFFMIDASNRHLITRPLGREILPSITRRIVEQIAPAAGLTVIERTITPRQAKKADELFLAVTTTDITGITHFDEHPIANATPGPYTKALAAEFQKLVKTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP2</accession>
    <name>A0A1U9NPP2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein STSP2_03083</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03083"/>
    <dbReference type="EnsemblBacteria" id="AQT69883">
        <property type="protein sequence ID" value="AQT69883"/>
        <property type="gene ID" value="STSP2_03083"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03083"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="15231" checksum="A4941537999FDDB4" modified="2017-06-07" version="1">MLWFPALRKRLRSNSAKLGKWGEKKSLKFLKNKGLKPITTNFRGRSGEIDLIMSDTDGRIIFVEVKTRASEHKALAHTAVTPRKQKHLIRTARDFCRQYSLNDRPMRFDVIAVVLPATGPAEIRHYENAFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV4</accession>
    <name>A0A1U9NPV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69640">
        <property type="protein sequence ID" value="AQT69640"/>
        <property type="gene ID" value="STSP2_02834"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02834"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="328" mass="38038" checksum="FCCF81027590FFFE" modified="2017-06-07" version="1">MKSRRTKKHGFTLMEVVLALALLAGVICAILAATSNLLQATLDSRNRMRAFETARMNMEKLLAQTSVEEMNEYGASEKYPEISWETVVEPFYEPITNRMWIQATCSATYLDRDAEQQQVELTNWVTDLSKEDVQKILDQQKREEEFLEELEEYPYGDSPEGLYKHASVLADTGDYQRTAIVVDELLERYPDSDPAEGIKNKLPEWSEEAADQGDYRSASRMGRTVFKYFPSSSAADQIRPKQSEWEEKEKTQPRNEPSQPDEPSDPRDPTDDNQDRDDQQDQQPDENQPDDQQQEKQAMDMTVEELMENYNIDRSTAEMFYKLFQSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ9</accession>
    <name>A0A1U9NPZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PIN and TRAM-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT70013">
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        <property type="gene ID" value="STSP2_03214"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03214"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="364" mass="40513" checksum="F4B533D3C5C3071B" modified="2017-06-07" version="1">MLFLMFIRAIFVVVVIALLLLSLKASSEDGMSIGMLSWRVGYTLAVTFFVIAVEWLTPKKALKSVAAAFFGLLIGVLISWAMSPVLLMLNDLYFQMSEEPLKMSQWLMGACICYLSMSLVVRTKDDKRFIVPYVEFSRQTKGLRPLVLDTSVIIDGRIADISETKLFDAPLIVPRFVLNELQLIADSGDKMKRTRGRRGLDMLNKLQSSTIVEVDIDDTPPPGMDINSPVDQKLVAFTKNCDGRLVTNDFNLNKVAQLRGVDVININDLANAMKTVTLPGEMMTVKIIKPGDSPQQGVGYLDDGTMVVVENARDKINQTIEISVTSSLQTSAGRMIFGKFEKMAANKPRSNGRPEKKKYDQKQN</sequence>
</entry>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="match status" value="1"/>
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        <source>
            <dbReference type="EMBL" id="AQT69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17338" checksum="D8CE7D5EBC928030" modified="2017-06-07" version="1">MVFDRIENAGRYAALGGGNLGRAFEVLQRQPFTQLPDGRYEVDGERLFFNVDSYQTQDWELGRFEAHRRYLDIQLITAGAEVIGHAHVGDLAEIEAYDGERDVAFYEPSIDTGTINMQPGMFAMFYPHDAHMPGRTLDEAANVRKVVIKVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA6</accession>
    <name>A0A1U9NQA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26331" checksum="89AF2EB81E715537" modified="2017-06-07" version="1">MGQFLYFIAAGEKADTLCSRLRSMAEQGIEITRRKCKGPEGKDGSIHTAEPAKRAMYLENEQTWMPSACGEFHVGYYDDDPPGPADIQRPDAIGGHPVEMCGQKWLVPAIRLIDGGSALPQAMTFENGRVIAEPIPRYAELSSRVEKFFDEFVAAHSPDSDGVVGTWADPMGSLELIADAMSLNYYIGVNELAVLRAVTTHSMKEAMMAMIDWPTVKKAAEAEAKKKRTDENCDTADGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB0</accession>
    <name>A0A1U9NQB0_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Phytochrome-like protein cph1</fullName>
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        </submittedName>
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        <name evidence="6" type="primary">cph1_10</name>
        <name evidence="6" type="ORF">STSP2_03108</name>
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    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ST-NAGAB-D1</strain>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
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            <begin position="350"/>
            <end position="589"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="590" mass="65821" checksum="663130BC34008765" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB2</accession>
    <name>A0A1U9NQB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03301"/>
    <dbReference type="EnsemblBacteria" id="AQT70099">
        <property type="protein sequence ID" value="AQT70099"/>
        <property type="gene ID" value="STSP2_03301"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03301"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SF4 helicase" evidence="5">
        <location>
            <begin position="328"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="604" mass="66391" checksum="B18AAA197524B80B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC1</accession>
    <name>A0A1U9NQC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mutM</name>
        <name evidence="17" type="ORF">STSP2_03337</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03337"/>
    <dbReference type="EnsemblBacteria" id="AQT70133">
        <property type="protein sequence ID" value="AQT70133"/>
        <property type="gene ID" value="STSP2_03337"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03337"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29522" checksum="FFF74D0B211DBEC2" modified="2017-06-07" version="1">MPELPDVETFKRYLDSTSLHHKMTGVKVHDKRILEGVSQSKLSKAVKGNEFENTRRHGKNLFVKSGSATLYFHFGMTGQLSYEQSDNGPVKYTRVQFNFENGHELDYVCRRMLGKVGLTESSDTFIEKESLGPDALDISEKQFCELLNSKTAGLKSFLMNQQTIAGIGNIYSDEILFNSKMHPKLKTSDLDDKACSKLYKNMIKVLNRSIEADADPSKMPNTYLLPHRRAGKKCPRCDGKIKMIKVNNRSTYFCPKCQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF4</accession>
    <name>A0A1U9NQF4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rsmH_2</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="8" type="ORF">STSP2_03366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03366"/>
    <dbReference type="EnsemblBacteria" id="AQT70161">
        <property type="protein sequence ID" value="AQT70161"/>
        <property type="gene ID" value="STSP2_03366"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03366"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="36133" checksum="B7B91DBE779A38AC" modified="2017-06-07" version="1">MSVNNRPTKKKGKHKAGRRSGRGKTAPGTHVPIMVSEVVNCLEPGPGQTVVDCTLGYGGHARKFLQKIGPEGRLIGLDCDAKELARTAKRLKKFGDAFVPRRANFSELEEVLGELEISKVDIIFADLGLSSMQIDDPGRGIHYKNDGPLDMRMDDRLERTAADVVAEISEEELAEALWKYSDEPDSGVIAAFICGQRQAAPITRVDQLKRIVLNAKGLTEATWKKQQKSQSFGGAHPAARTFQALRILVNDELGALEQLLEAAPGCVKAGGRIGIISFHAGEDRLVKNAFREGLKKGVYQAVSKGAITPRQGEIRKNPRSSSARFRWAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ9</accession>
    <name>A0A1U9NQJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69786">
        <property type="protein sequence ID" value="AQT69786"/>
        <property type="gene ID" value="STSP2_02983"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02983"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9731" checksum="86FCAAD37FB85C93" modified="2017-06-07" version="1">MSTTAIKKGSIEVVAVLCALYLFFKDYEAVRKGVLQFSNDISKASRSLYQVVKKKYLSEENRALKRKKAEKIVREQEDSKIKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK9</accession>
    <name>A0A1U9NQK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fucP_2</name>
        <name evidence="7" type="ORF">STSP2_02993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02993"/>
    <dbReference type="EnsemblBacteria" id="AQT69796">
        <property type="protein sequence ID" value="AQT69796"/>
        <property type="gene ID" value="STSP2_02993"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02993"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="393" mass="41628" checksum="0DAF7C1460275B61" modified="2017-06-07" version="1" precursor="true">MRMKTVPILLTFFAMGVADAMGPMSDAVKENYELSNVMATLLSFFVFIAFAVFSVPGGLLAARIGKKKLLLLGLGLNVVAMAVPCFIVPNFALLLACIFALGVGTTFLQVAGNPIMHDVSAEGNYGRNLSFAQGFKGIGSTASTYLVTAIAGIALFSSMGWRGVFPFFALLMAGAFIWVACIKVKETQPDTPPNIGSSLSLLKKPVFALAVLGIFLYVGSEVCMARFLKPLLENMGLSADKATSFGPGFFFLLLTIGRLIGGAVLNFMTSRTFFRVSAAMGLAGAIILTTGVSSIAVVGVALAGFGFANIWPMLFSITVEKDPERGSELSGLMCMAISGGALIPLLMGKFVDLDWGPRAFIVPVVCFVYLTILSLQNDKPKQAEMVEEAVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ8</accession>
    <name>A0A1U9NQQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">gcvPA</name>
        <name evidence="5" type="ORF">STSP2_03359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03359"/>
    <dbReference type="EnsemblBacteria" id="AQT70155">
        <property type="protein sequence ID" value="AQT70155"/>
        <property type="gene ID" value="STSP2_03359"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03359"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="48946" checksum="8DCD0B62E713BE37" modified="2017-06-07" version="1">MPFISNTDQQQQQMLEAIGLTMDDLFADIPDELKIKNLELERGLTEQELQVRLQALSGKNSTHLTYFLGGGFYDHFIPAAIPALAGRSEFYTAYTPYQPEISQGTLQAIYEFQSMICRLTGMEVSNASMYDGGTAMYEAMMMALRKTRRNKVIIDDSVNPIYRVMIHSYTQNLNIELDETKHSDGRANRDAILEQLDKETGAVILQNPNFFGCIDDFTDIAEAAHEKGALLIMCCYPTSLGILKTPGSMGADIVVGEGQCLGLPLSFGGPYLGVLATTRKLMRKMPGRIAAETTDGEGNRGYVLTLQAREQHIRRDKATSNICSNEALCALQASIYMSLLGKKGLKDIANLCADKASYAFDRLTAVPGVKARWGKNWFYNEFVIDLPTDATDVVSKLIEKGIAAGFPLSRYYEGMDNALLIAVTEKRTKQEISTLADALEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS9</accession>
    <name>A0A1U9NQS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzylsuccinate synthase alpha subunit</fullName>
            <ecNumber evidence="5">4.1.99.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bssA</name>
        <name evidence="5" type="ORF">STSP2_03489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.99.11" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03489"/>
    <dbReference type="EnsemblBacteria" id="AQT70283">
        <property type="protein sequence ID" value="AQT70283"/>
        <property type="gene ID" value="STSP2_03489"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03489"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018805">
        <property type="term" value="F:benzylsuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="3"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="668"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="787" mass="87948" checksum="78C283B9C82D2972" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT6</accession>
    <name>A0A1U9NQT6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Znf/thioredoxin_put domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69980">
        <property type="protein sequence ID" value="AQT69980"/>
        <property type="gene ID" value="STSP2_03180"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03180"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22612" checksum="B32182D2DDD354DB" modified="2017-06-07" version="1">MQVRCGNCQKVYEVGEDWAGKKVKCKACGHSFEVAEQTKPEPQAEDEQEQTEQIRCLDCYYRFFPDPNDGNLAACPRCGTSHVRTKRSTKSDGRLQKGRRVKMPSDNDSMAGLFILEGAMLLTFTAFVGLGTMDGGIEGAIAGVISVITGTFALAMISSGIAAKVLRISEMIANQRIIRNELIMLNEQLDQEDAEGAGVKISREKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU8</accession>
    <name>A0A1U9NQU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">STSP2_03086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03086"/>
    <dbReference type="EnsemblBacteria" id="AQT69886">
        <property type="protein sequence ID" value="AQT69886"/>
        <property type="gene ID" value="STSP2_03086"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03086"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32390" checksum="6488F645171065C5" modified="2017-06-07" version="1">MATQTWTIKKLLDWMIPFFENKGVDAPRLAAEMLLSNVLGLERIQLYMHYDKPVGPDKLAKLRDLVKRAGEHEPVAYLVGHTEFYSMQIDVSPAVLIPRPETEGLVERAIEFLRERQVPRYVLELCTGSGCIAAAVAKGVEDVKVIATDICDEAMEVAGRNVEKHGLGEKVELCGGDLFEAVEGFADKQFDLIVSNPPYVTEAEYEGLDRNVKEYEPARALVAGEKGLDIYERMMGELATYLKPDGAVMLEIGYQQGDAVRELLEGTGLFSEVRIEKDFARHDRIAVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV2</accession>
    <name>A0A1U9NQV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-synthase adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moeB_2</name>
        <name evidence="3" type="ORF">STSP2_03509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.80" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03509"/>
    <dbReference type="EnsemblBacteria" id="AQT70303">
        <property type="protein sequence ID" value="AQT70303"/>
        <property type="gene ID" value="STSP2_03509"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03509"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29139" checksum="074788544EC175D3" modified="2017-06-07" version="1">MTQQNFHKRFARTARLVGPEGVKRLSSAHVAVIGLGAVGSYAVEALTRAGVGNLTLVDFDQITHSNMNRQLYALESTLGQPKSEIARRRVLDINPDCNVRALHTFIHHDTVRSVLEPRPDIVIDAIDSLNPKVELLTALHELAIPTVTSMGAALRTDPSAIRVAKLKKSYNCPLARLVRKRLRRRNIPLDFTCVYSTETTDNLPDHAIGSDRADEHDHSFRGRQRSTLGSLPTITGIFGLTAANTAIKMLAGETAQREPKARKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV9</accession>
    <name>A0A1U9NQV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70108">
        <property type="protein sequence ID" value="AQT70108"/>
        <property type="gene ID" value="STSP2_03312"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03312"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="200" mass="22479" checksum="F61061ABDE6CF990" modified="2017-06-07" version="1" precursor="true">MRQLTTVLIIVSAVVMTGCGNGARSSLYDKVDQLQSQNQELTKQVQHLEQQNEKLSERVDTLLAVGPEARASALPALDRIELSSRSGIYDKDNDDKAESLVVYIQPHDEAGDPFKAPGSVEVQLWDLQADASDAMVGRWQIKPDQLKEMWAGTFMTNYYRLKFDLGFQPADDKEYTAKVTFKDYLSGTVFREQAVVQVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW7</accession>
    <name>A0A1U9NQW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03211"/>
    <dbReference type="EnsemblBacteria" id="AQT70010">
        <property type="protein sequence ID" value="AQT70010"/>
        <property type="gene ID" value="STSP2_03211"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03211"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="32061" checksum="F60AF6066274B870" modified="2017-06-07" version="1">MIWLLPLIILLAYSIIGWTIYFIQPSLLYQPKRTVLYDPSDIGLAFENVTLNSTAGCKLSAWFVPAVNARLTVLLCHANAGNISHRLDTVKIFHDLGINCMLFDYQGYGLSQGSPTEQGTYDDARSAWNWLTRIKGIPENSIILFGRSLGGCIAAQLASSVHPAGLVVESAFTSYIEIGKHYYPFMPVKLFAEYRYPTADYIRRIDCPLLIMHSKADKVVPYEMGLKLHDIAHEPKEFARIYGSHNEGFLHSGSRYIDIWDNWIRRIATSTPDVRPEQLRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB9</accession>
    <name>A0A1U9NRB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70076">
        <property type="protein sequence ID" value="AQT70076"/>
        <property type="gene ID" value="STSP2_03278"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03278"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="278"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="53515" checksum="DF4A02418827A218" modified="2017-06-07" version="1">MRKKRKRGRPPKYVSDERGRPLVGLSCDDNGFYNTHYRTEGVPRLHFGAPDDYINALRRFRRWRDEREKKTTSIVFDQDDDKESVLNQVHQRILNNKDGWGEWRASIDCEEYIDPPVDLKINEEIGWDIARSLISNNPPSIVAEKLGIPEFAELHKLTPLPKPLTLHEIGEIYLKRTKKPLRQQEYDDSKRWWEQFCKLAKSKTVRDVCLSDIKRYQDALYELFNKHEYSPTWIKHRFDKIKTILRYALKSDAVEYTKDIEDVLVLCKKFVYPERASVDPKPIHREDFQKIFALANAKEKAILLLAANAALYPQDVCDLKKAYINLQKKTLVMDRGKTGVPRVACLWDRTVRAIERAQAEAPHDSEFLFITFLGKPYCAHGIGSIWRKLRKKAEVDHAVKFEHIRDACQTAGVDANCTLDEVRFLLGHRVAGVTDHYLKRRPNLTQKACEEIEKYFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC3</accession>
    <name>A0A1U9NRC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase B</fullName>
            <ecNumber evidence="7">2.1.1.176</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmB</name>
        <name evidence="7" type="ORF">STSP2_03561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03561"/>
    <dbReference type="EnsemblBacteria" id="AQT70355">
        <property type="protein sequence ID" value="AQT70355"/>
        <property type="gene ID" value="STSP2_03561"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03561"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="198"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="287"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="466" mass="50719" checksum="7AD39FE2F19E26B7" modified="2017-06-07" version="1">MGDSGKVSARAVALLVLGKFDPAAGDASEVLYRYIGRTEGRGQATDIVFGVIRHRKTIDHLLALIGNVQAKRVQKRLMNVLRIGVYELVFAAETAEYAIVNEAVELARTRGGRRQAGFVNAVLRNVGRAIAERKCGADEADKLDFVPVSARWGCRFKRDVLPDEAEGAGRYLGLKYSLPGWLAGKWAEQFGRETAERICLGSNRKPGVWIRPNRLKTTLRELCSRFGEAGVEFDLWLERDMLRLRGGVSVPELPGYDEGLFSVQDPTAAKVGEIVGPKAGEVVLDMCAAPGGKTTHMAELMGDEGLVIASDVDTERLGMVVENCQRLGISAVKAVDIHKMGEAVEKAGGADRVLVDVPCSNTGVMARRCEVRLRINHEKAASLAGVQYGILTEASKYVKQGGAICYSTCSIMDEENCAIVRRFLEEHEGWSIESEELTLPGVGICGEDVSGDHDGGYACLLRRYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRI2</accession>
    <name>A0A1U9NRI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosynthetic reaction center H subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03340"/>
    <dbReference type="EnsemblBacteria" id="AQT70136">
        <property type="protein sequence ID" value="AQT70136"/>
        <property type="gene ID" value="STSP2_03340"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03340"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="247" mass="28610" checksum="B5288AA629D55513" modified="2017-06-07" version="1">MLLSANYLIDFNVEATDGNIGTVYDYYFDDRGWKIRYVVVDTGKWLPGRKVLLSPVCIENVTVPDRVLPVELTREKVKNSPEISADMPVSKQYEVELHKYYGWAPYWTGQFTAETGGVIAMPPMEADPGERSEEQIESTHLRSIREVRGYHIHASDGKIGHVDDIIVETKNDMIRYLVVDTHNWLPGKKVIIPPQWARDIDWAEKSVQMDVDRQAVKESPEFDPEEGVNRELEIRLYDYYGRPKYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRN8</accession>
    <name>A0A1U9NRN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trpB_2</name>
        <name evidence="12" type="synonym">trpB</name>
        <name evidence="14" type="ORF">STSP2_03486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03486"/>
    <dbReference type="EnsemblBacteria" id="AQT70280">
        <property type="protein sequence ID" value="AQT70280"/>
        <property type="gene ID" value="STSP2_03486"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03486"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="75"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="50630" checksum="0BB6C6D2B65B163E" modified="2017-06-07" version="1">MDHKILLSESDIPKKWYNIAADLPTPMLPPLTADGTPISPESLAPVFPMNLIEQEVSTERWIDIPEEVLDILYRWRPAPLRRATYLEKYLDTPAKIYYKDESVSPPGSHKPNTSVPQAWYNKQFGIERMTTETGAGQWGSALSFACSLVGIECRVFMVRISFDQKPFRKIMMQIWGGNCVASPSTETAAGRQVLDANPDTPGSLGIAISEAIEAAVSDQSGKTRYGLGSVLNHVMLHQSIIGLEAKKQLEMVGEGLPDVVIGCAGGGSNFAGLAFPFTQDKINGADIEIIPVEPTACPTLTKGPFSYDYGDIACMTPLMPMHSLGHSFIPEPIHAGGLRYHGMSPLVCQCVVEGLHTPQALDQMECYESALLWARTEGSICAPETSHAIAAAIREAKKAKEEGKEKTIIFTYSGHGLMDMTGYDAYLSGKLSEYHLPDEEIARAEECLKNHPQAEQRKTGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS48</accession>
    <name>A0A1U9NS48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative teichuronic acid biosynthesis glycosyltransferase TuaC</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuaC_2</name>
        <name evidence="2" type="ORF">STSP2_03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1U9NS48"/>
    <dbReference type="EnsemblBacteria" id="AQT70336">
        <property type="protein sequence ID" value="AQT70336"/>
        <property type="gene ID" value="STSP2_03542"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03542"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40165" checksum="A540ABDBEAC52D94" modified="2017-06-07" version="1">MRTIELMPYLRQRGIRLDFCTLSNDTAPGSLDSLIKQHGGDVLQCPLKLQPWSFHHRLKNILKEGNYDAVHSHVFMFSGYVAFIAKQANIRSRVVHFRTTSDGGKKRNFSRKGYNKAMHYLVDKYATDILAVCIGAMEVGWRVDWRQDPRCKIVYNGIDVSKFQRKKDISSEVRCDLNLPQQSKLVVCVGRLIPDKSQNVLIDAAPEILGCNPDTHVLFVGDGPERSSLSDKVVRTSLEQRIHFLGTRTDVPELLLASDCFVLPSKREGLPGVVLEALMANLPVVATDLPGVREIQNYAPHVKIVPFGDSHALAREVSKSLCRNEHLHIHDRFYEAFDLKTCAEKLADVYEESLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG90</accession>
    <name>A0A1U9NG90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">guaD</name>
        <name evidence="4" type="ORF">STSP2_00089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00089"/>
    <dbReference type="EnsemblBacteria" id="AQT66951">
        <property type="protein sequence ID" value="AQT66951"/>
        <property type="gene ID" value="STSP2_00089"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00089"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20339" checksum="3419176714EE19D8" modified="2017-06-07" version="1">MAKPEFRLELPGWVETYLGSYGDKFDSSESRMRLAVGLSRRNIEEGTGGPFGAAIFARDTGRLIATGVNMVTSLGCSIWHAEMAAIARAQMRLRTYELGRDEPMELVSSCEPCAMCLGAVPWSGVSRLICGARDEDARAAGFDEGAKPADWIDELAQREIEVIRDVLRNEAAAVLADYAAGGGEIYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGD7</accession>
    <name>A0A1U9NGD7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable pectate lyase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00131"/>
    <dbReference type="EnsemblBacteria" id="AQT66993">
        <property type="protein sequence ID" value="AQT66993"/>
        <property type="gene ID" value="STSP2_00131"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00131"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013687">
        <property type="entry name" value="Disaggr-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08480">
        <property type="entry name" value="Disaggr_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002076" description="Probable pectate lyase C" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Disaggr_assoc" evidence="3">
        <location>
            <begin position="973"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119280" checksum="57129F7BD0CAFABF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP8</accession>
    <name>A0A1U9NGP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67113">
        <property type="protein sequence ID" value="AQT67113"/>
        <property type="gene ID" value="STSP2_00254"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00254"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27905" checksum="A0A3C36148727F3E" modified="2017-06-07" version="1">MFYKDGIDRVRAFGIASGYGENGAGREVPYAALVKWQSQHGDKLHQVYVNGELAGVSSDCGVRQMVVGLPVCFEGPVRIEVVAVDPGEGWKQFDVCDEPGSLNGRVELRWVKLHGLPYEGRYEVYMAVDDEVVDFDSQPFDEGPIWRGPWEKAGFGLDGFGSGGFGFDAGNACGFGRGCFGEGEFGLDAEEFRWVSDELGTGKYRFGVKFLDVWGGEVCRMTSDEITIIRKCRGVKKIRLIEQSDDGSLKIAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ5</accession>
    <name>A0A1U9NGQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">apu_2</name>
        <name evidence="4" type="ORF">STSP2_00262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67121">
        <property type="protein sequence ID" value="AQT67121"/>
        <property type="gene ID" value="STSP2_00262"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00262"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="2">
        <location>
            <begin position="815"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1128" mass="120977" checksum="298859C983525BAE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS8</accession>
    <name>A0A1U9NGS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligoendopeptidase F, plasmid</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepF1</name>
        <name evidence="8" type="ORF">STSP2_00153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00153"/>
    <dbReference type="EnsemblBacteria" id="AQT67015">
        <property type="protein sequence ID" value="AQT67015"/>
        <property type="gene ID" value="STSP2_00153"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00153"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="192"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="587" mass="67818" checksum="7266D11FA2585C41" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH05</accession>
    <name>A0A1U9NH05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thrC</name>
        <name evidence="6" type="ORF">STSP2_00177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00177"/>
    <dbReference type="EnsemblBacteria" id="AQT67038">
        <property type="protein sequence ID" value="AQT67038"/>
        <property type="gene ID" value="STSP2_00177"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00177"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="87"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="450" mass="48845" checksum="4FA6DF228F2F275C" modified="2017-06-07" version="1">MANNSDYAFQKCINPECAATFDVAEILVKCPTCGDMLDVAYDWDKMDVPGSLKDFEKRWTRTNPLDFSGVWRFRDLLNFCPDDCKVTVGEGQTILQRNDALAKDLGIDAGCLHLEYEGLNPSGSFKDNGMTAAFSHARLVGATASACASTGNTSASMALYAHSTGMSCTVFIGSGRIAYGKLSQAMDYGAHTLQIAGDFDDCMRQVQAVCAQLGIYLVNSLNPFRLEGQKTIMFRILEQLGWQVPDWIIVPGGNLGNSSSFGKAFAELKQLGLIDRVPRLAIINAEGANTLTHLYNDRNLRWNDGRPDADLVQEFYDDLTARKYSPRTVASAIEISRPVNLTKCLRALDICDGVVISVPDEEIIDAKAQIGLRGLGCEPASAATIAGLKHLLADGVVDPSAKIACVLTGHPLKDPNLTVNYHKDNKGKFSNPPVEVPNDLNAIIKAMKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH31</accession>
    <name>A0A1U9NH31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">STSP2_00384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00384"/>
    <dbReference type="EnsemblBacteria" id="AQT67241">
        <property type="protein sequence ID" value="AQT67241"/>
        <property type="gene ID" value="STSP2_00384"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00384"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22859" checksum="9282648ECD565817" modified="2017-06-07" version="1">MFTGLIEKVSAVKTVRPTAGGKVFTIDLGPLAEDAHLGDSIAVNGVCMTITAITGTIADFDVSGETLRKSTLDSLRVSAPVNLERAMAMGQRFGGHIVQGHVDGVATIRTIETKGDFWDITFAADSEILDEIVPKGSVAVNGISLTVARMDANSFSVALIPTTIKDTNLASAKVYDKVNIETDIVTKVVKKQVEKILPDKAGKTLTVDKLRELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC0</accession>
    <name>A0A1U9NHC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC</name>
        <name evidence="2" type="ORF">STSP2_00285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00285"/>
    <dbReference type="EnsemblBacteria" id="AQT67144">
        <property type="protein sequence ID" value="AQT67144"/>
        <property type="gene ID" value="STSP2_00285"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00285"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16461" checksum="8B76F96A8213DD0B" modified="2017-06-07" version="1">MSQAKKKLNVLFLCTGNSCRSQMAEGWAKHLKGDVIEAFSAGVSPGKLNERAVEVMAEAGVDISYHVPQHVDDYAEIEMDYVVTVCDHAHETCPVFPGATKVVHRKFEDPSFKIGTIEEVMAEFRRVRDEIRDFVSEMPGNLEEMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI3</accession>
    <name>A0A1U9NHI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW_1</name>
        <name evidence="7" type="ORF">STSP2_00210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00210"/>
    <dbReference type="EnsemblBacteria" id="AQT67070">
        <property type="protein sequence ID" value="AQT67070"/>
        <property type="gene ID" value="STSP2_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00210"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="415" mass="46017" checksum="D70A2F9E3C0592AF" modified="2017-06-07" version="1">MKSFLHGRLVIVRLIMLAAMLSLVAIGIATIYASGHPAEVDEASKYAGAWKKQAVYAAGGMMAFIFVNLFDYRKLGPLSYWLYGGILAVLAVLLLGKRMDIPFVPVINGTCRWIRLGIGSRFVQVQPSEFCKIIYILALAWYLRFRKNYRQFHGLIGPFALTLLAMVLILFEPDLGTVLLMMPILFSMLYVAGAKPKHLLTIVALGVISFPFLWGHMNHYQRQRISCVLLQSDYMKDLAQKNGRVAEVLTGNDRFNPKAWERGNGWQLKHSKLAIASGGIKGYGWRKGPYIKYNTLPERHNDFIFAIIAHQWGLIGCAVVLGLYAVLIGCANEIAWANTDAFARLVTVGIMAMFTVEVIVNISMTLGLMPITGLTLPFVSYGGSSLVVSMMAVGLLNNIGRERPFSVAGRAFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR5</accession>
    <name>A0A1U9NHR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67482">
        <property type="protein sequence ID" value="AQT67482"/>
        <property type="gene ID" value="STSP2_00629"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00629"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6684" checksum="6141951DE91CED79" modified="2017-06-07" version="1">MISLAGFGVVGKLFVWNGCFGWFGVVSVGEMVIMRGLGAGFERLSVFLIVMDSVFRFLGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT0</accession>
    <name>A0A1U9NHT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67160">
        <property type="protein sequence ID" value="AQT67160"/>
        <property type="gene ID" value="STSP2_00303"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00303"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9602" checksum="6FB1DEC46C9B6049" modified="2017-06-07" version="1">MMPERNGGSEDLFWEQRGWHISGCLQEEAIRARSAARFLVSSYSNSAVKPAHDLSLGGMSVCAWAYCLNLNHSTVFAATNIFFMTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ5</accession>
    <name>A0A1U9NHZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00697"/>
    <dbReference type="EnsemblBacteria" id="AQT67549">
        <property type="protein sequence ID" value="AQT67549"/>
        <property type="gene ID" value="STSP2_00697"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00697"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32380" checksum="0B668449A642011E" modified="2017-06-07" version="1">MANGKDNNKAVSGQLLEFVPDSYLDRTSRPVYALVYLLGFIVFYEFGTIMMNPAILDKTLSQWHVRVVSFVWIQNILEYLGFSHRMTWIAAPAAVIIILLVLQITSKSSWYVNLFDFIPMTLECIVLAVPLLVLSLLVNAYPIGQAAGGFLAEISAQAGEGGFLLSPLMSQIITGIGAGIYEELIFRLILISIIMIVLQDFIGLGKGSSLFIAIVVSAFLFSIHHHFFFVDGEFTTSKHDPFTVATFTFRFLAGIYFAAVFAFRGFAIVASSHAFYDIIAALLNTFAFNPPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI23</accession>
    <name>A0A1U9NI23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin HigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">higA</name>
        <name evidence="3" type="ORF">STSP2_00542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00542"/>
    <dbReference type="EnsemblBacteria" id="AQT67398">
        <property type="protein sequence ID" value="AQT67398"/>
        <property type="gene ID" value="STSP2_00542"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00542"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11298" checksum="D9BC427DD91FF174" modified="2017-06-07" version="1">MARKFSELEKRMDPESVKRAKARAREEMAQMLLAEIRKETGITQENLAKSMGIKQPSLSKLESQRDMQISTLRRLIEALGGKLELIAHMPEGDIKISQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI76</accession>
    <name>A0A1U9NI76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00790"/>
    <dbReference type="EnsemblBacteria" id="AQT67642">
        <property type="protein sequence ID" value="AQT67642"/>
        <property type="gene ID" value="STSP2_00790"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00790"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032740">
        <property type="entry name" value="GxDLY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14607">
        <property type="entry name" value="GxDLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843865" evidence="1">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GxDLY" evidence="3">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="183"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40954" checksum="ED4BCD44DAE5B907" modified="2017-06-07" version="1" precursor="true">MSFLRMCFVFGLVTAVLGVAVAEEAGGMVWRDGSELRIDGKGWSDTPTPYSRLPERAEEKVRKPVWDRSLKSAGLVIHFNTDARKISFKWTLTSGSLAMHHMPATGVSGLDLYVKNADGKWLYVRNARPTGKSSTGSVNIWDAEKGNMREYKLYLPLYNGIESLQIGVPEGAKFEQPDVSDAKPIVYYGTSITQGACASRPGMAFAAMIERELGVPLINLGFSGNGRMEPEVAELLAELDPQVYVVDCLWNLTRAEDETIQERARNLIWKIRSKHAETPILFVGQSNFRGLRTGKTEALLEELEKAGDNRVENVHFLPGRDLLGDDGDGTVDGVHPNDLGMRRHADVLIPAIRELIAEEPEPKDAGEAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC8</accession>
    <name>A0A1U9NIC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67575">
        <property type="protein sequence ID" value="AQT67575"/>
        <property type="gene ID" value="STSP2_00723"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00723"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956676" evidence="4">
        <location>
            <begin position="27"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="377"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="57512" checksum="7AB40099D3C344A8" modified="2017-06-07" version="1" precursor="true">MKPITRRNFLKVAGISAAAVSLPGCAGQFMTQKPKRKPNIVFIMTDDHASHALSCYGSKINKTPNLDRIAEEGMRFDNCFCTNSICAPSRAVILTGKYSHINGKIDNTPVPFDGSQQTFPKLLRKAGYQTAMIGKWHLRSEPTGFDYWNVLPGQGAYHNPVMIEMGERKKYDGYVTDIITDKAIDWIEQRNNDQPFCLLYQHKAPHRNWQPDEKHADMYKDRKIPLPETFNDDYATRSDAAREQEMTIEKHLRVPYDTKVKPPEELSGQELKEWKYQRYMEDYLACVASVDDNVGRFLDYLEEKGLAEDTVIVYTSDQGFYLGDHGWFDKRFMYEESLRMPFLVKYPGLIKPGSVNKDIVVNIDFAPTFVDMAEARIPNDMQGRSLMPLLAGDTPDDWRTAMYYHYYEYPAVHQVKRHYGIRTKRYKLIHFYNDIDAWELYDLKKDPNELNNIYGNPQYSDLVTKLKSRLEDLREKYGDSDELTREVINRRAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID1</accession>
    <name>A0A1U9NID1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">nfi</name>
        <name evidence="2" type="ORF">STSP2_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00484"/>
    <dbReference type="EnsemblBacteria" id="AQT67340">
        <property type="protein sequence ID" value="AQT67340"/>
        <property type="gene ID" value="STSP2_00484"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00484"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="224" mass="25206" checksum="77A0D483546DAB15" modified="2017-06-07" version="1">MRVKNLHGWDLDYKQARALQEELAGKLRFTSFDKKPKLVAGLDCAFSKDGSRIGAVIVVMRWPDFEIVETAEAVRPVQMPYVPGYLSFREGPACIAAAMKLKHVPSVFIIDGQGTAHPRRMGLASHLGLFFDRPTIGCAKSRLTGEHDEPGPEKGDYAWLWDDNEKIGAVLRTRTRVKPVYVSPGHKCTRQDAIRIVLQCTTKYKLPEPTRIAHQLVTKMKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG3</accession>
    <name>A0A1U9NIG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ORF">STSP2_00725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00725"/>
    <dbReference type="EnsemblBacteria" id="AQT67577">
        <property type="protein sequence ID" value="AQT67577"/>
        <property type="gene ID" value="STSP2_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00725"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="373" mass="38734" checksum="7373E2D3A4FD995F" modified="2017-06-07" version="1">MKIVVAMDSFKESLSARRACAITAGVIGEVLSDSQVITKPLADGGEGTADAMLAADGGEWISCDVMGPLAGMQAEAGFAWFEKDRSALVEMAKASGLELLTDGQRNPLRATTYGTGQLIRKAIECGAEKVYLAVGGSATVDCGVGAACALGWQFRLADGSDYVPGESRLNDIREIVEPEVPIGREVMVLCDVDNPLCGPRGAAKVYGPQKGATPKMVAELEAGLENIAELVEEQLGMSITDMPGAGAAGGLSAGAVAFMNAGLTSGTEYIIGKSGLVEALNDADWVVTGEGRLDEQSLQGKVIHGVMKCAKRHGVKVAVLAGQVALDDRTLEEQGIDIAMQCMEPDMTVEAAISEAGELLSERAAELAQELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK0</accession>
    <name>A0A1U9NIK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulation protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nreC_1</name>
        <name evidence="5" type="ORF">STSP2_00911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67762">
        <property type="protein sequence ID" value="AQT67762"/>
        <property type="gene ID" value="STSP2_00911"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00911"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="26339" checksum="603AFB6B9DE24E30" modified="2017-06-07" version="1">MEIVRVYSIAAAHLNYRFMEKCMATRIILADDHEIMREGLCALIRKCDDLEVVGQASDGRKAIEMVQELKPDIAIMDISMPGLNGIEAARKMLAANSDIKIMGLSTHSTRSMVVKMLKAGALGYMLKESAFSELKQAIETMLQGKTYLCSRTSEVVLADYMNMISDPKKIGRDILTPREKEVLQMVAEGLTTKEIAAQLSVSAKTIDSHREHIMEKLKMHNVASLTKYAIKEGLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV9</accession>
    <name>A0A1U9NIV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoD_1</name>
        <name evidence="6" type="ORF">STSP2_00593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00593"/>
    <dbReference type="EnsemblBacteria" id="AQT67446">
        <property type="protein sequence ID" value="AQT67446"/>
        <property type="gene ID" value="STSP2_00593"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00593"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="542" mass="62691" checksum="18FD3987D806801A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ1</accession>
    <name>A0A1U9NIZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein OprM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oprM</name>
        <name evidence="3" type="ORF">STSP2_01054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67902">
        <property type="protein sequence ID" value="AQT67902"/>
        <property type="gene ID" value="STSP2_01054"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01054"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="497" mass="55730" checksum="01CB3C54389EC8C6" modified="2017-06-07" version="1">MMTSRALMNSIGIRLIILVLTILLGQGCTVGPDYSHPGLLVPDKWQAELQRGLNADELDVAGWWQRYSDPTLIELVETARSKNLDVQQAFVRIAEARSALAATMGRYYPDINASGYYTRFRNSENITAIEAAGTSGDQYNIHNLGFDASWEIDVFGDIRRSVEASRAAYEATIEDFHDVLVILTADVAFNYFELLATRKRINFAEQNIILQKEMRELTKNRFDAEIAPELDVEQAELNLANTESILPTLRILETAALNRLAVLLGKNPGQIDKLLTDRTELPALPDDILVGLPVELIRHRPDIRSAERELARQVAEIGIATSELYPQFSLDGFFAFQSLDLSTLDNWGSRTYGFGPAFVWNIFDGNRIRNNIDIQKSQADQALVGYEQTLLLALEDVENAMVAYVQERERSDALQRSVTAARRSVELVSELYRNGLTDFQNVLDMQRTLFEQQDQLAQSSGQVAINSARIYKALGGWWDKDVQKAQDSQAITADGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ14</accession>
    <name>A0A1U9NJ14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67923">
        <property type="protein sequence ID" value="AQT67923"/>
        <property type="gene ID" value="STSP2_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01075"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007731">
        <property type="entry name" value="DUF669"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05037">
        <property type="entry name" value="DUF669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16995" checksum="6E7151D328CB573F" modified="2017-06-07" version="1">MAYLNNFDANTVDPAQSFEALPAGKYIAAITESEMKPTKNNNGHYLQLTLDVLDGQYKGRKVWARLNLDNPNAQAVQIARGELSAICRAVGVMQPRDSVELHNLPLCIKVTCKKRGDTGEITNEIKGYEKKEAAFAAAPSVPAPQATNNTPPWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ83</accession>
    <name>A0A1U9NJ83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)/drug antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM</name>
        <name evidence="2" type="ORF">STSP2_00724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00724"/>
    <dbReference type="EnsemblBacteria" id="AQT67576">
        <property type="protein sequence ID" value="AQT67576"/>
        <property type="gene ID" value="STSP2_00724"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00724"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="474" mass="50657" checksum="5FC82199B34C210A" modified="2017-06-07" version="1">MRLNGFTKKSPYQAKALDLSDEKLGRTILSLALPAVMENLMFTLVFMADTMIVGWLRDPNALAATLLGSRIMFFTRAPFYGISIAATSLVSRHWGASDFATARRHAAHAMVVAFVLAGLATAILFPIASLAMDALGADSDVLPLAATYARIVILSIFLGQPMIVANGIIRAAGDTKTPMANTMIMNFTNVGLSLALAFGIGPFPALGLVGVAYGTLISRSLGGLLSIIAVLNPMGAVNMPFSWMFRPRLGYYKSLLSLAWPAIAERSSYSVADLFFTRIVAGIGTTALAAHQIAVHIESLAFMPCVGISYASATIVGQAIGAQRHSFAERAVKRIILWAGLAMVGLGVIFVLFGPLCVSVFGATPEILEQAGLALQISALELPFLAAALILGVSLRSAGDTTSPLYITIISLILFRVGGAYLLGIHFEMGIAGIWLATAMDWIGRTSGMWYFFSAGKWKWIHQRQQMKQAAMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA2</accession>
    <name>A0A1U9NJA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cas2_1</name>
        <name evidence="9" type="synonym">cas2</name>
        <name evidence="10" type="ORF">STSP2_00798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00798"/>
    <dbReference type="EnsemblBacteria" id="AQT67650">
        <property type="protein sequence ID" value="AQT67650"/>
        <property type="gene ID" value="STSP2_00798"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00798"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13682" checksum="8A0BF08B20271F9C" modified="2017-06-07" version="1">MSGTTENRNLSGYRAVWLFAMFDLPTDTKRARKDYTIFRKRLMKDGFAMVQYSVYVRHCASEENAQVHYKRVKGFLPPEGEVRLLQITDKQYGRMEIFWGKKRKPTPAAPKQLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG0</accession>
    <name>A0A1U9NJG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68051">
        <property type="protein sequence ID" value="AQT68051"/>
        <property type="gene ID" value="STSP2_01205"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01205"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11605" checksum="5E493BAFC02ABA22" modified="2017-06-07" version="1">MKNNHPKYITIAKSDDRELLERLLKLLNKKSIDAQVITADPADTPMHSTLKVAEHQYDTAYDFVQHITSRGCTFGLPHVKSSKRPDRKDRSSVKQSRSTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG6</accession>
    <name>A0A1U9NJG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68069">
        <property type="protein sequence ID" value="AQT68069"/>
        <property type="gene ID" value="STSP2_01224"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01224"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013069826" evidence="2">
        <location>
            <begin position="26"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="509"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="3">
        <location>
            <begin position="509"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="809"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="989" mass="106785" checksum="DD8212DA68F5769D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK4</accession>
    <name>A0A1U9NJK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67914">
        <property type="protein sequence ID" value="AQT67914"/>
        <property type="gene ID" value="STSP2_01066"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01066"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
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    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="14"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="534"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="699" mass="82887" checksum="0D4358345CC4AF66" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL4</accession>
    <name>A0A1U9NJL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crossover junction endodeoxyribonuclease RusA</fullName>
            <ecNumber evidence="14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Holliday junction nuclease RusA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Holliday junction resolvase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">rusA</name>
        <name evidence="17" type="ORF">STSP2_01076</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RusA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01076"/>
    <dbReference type="EnsemblBacteria" id="AQT67924">
        <property type="protein sequence ID" value="AQT67924"/>
        <property type="gene ID" value="STSP2_01076"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01076"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016281">
        <property type="entry name" value="Endonuclease_RusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001007">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14616" checksum="A275FAE8B970893B" modified="2017-06-07" version="1">MVLTLPYPPSINHYWRRVGQRTLISREGRTFRKKVCALLGRGIEPLEGRLAVVLDIYPPDRRRRDIDNVQKALLDAVEHAGVYRDDSQVDLLITRRRDVVKGGRAVVHITDISTARNLLSKLAKELHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL6</accession>
    <name>A0A1U9NJL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00919"/>
    <dbReference type="EnsemblBacteria" id="AQT67770">
        <property type="protein sequence ID" value="AQT67770"/>
        <property type="gene ID" value="STSP2_00919"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00919"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="912" mass="99929" checksum="7DA90BB17A7EB8D8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ2</accession>
    <name>A0A1U9NJQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zraR_2</name>
        <name evidence="2" type="ORF">STSP2_01318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT68163">
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        <property type="gene ID" value="STSP2_01318"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01318"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="157"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="490" mass="55896" checksum="72C1B0728F576319" modified="2017-06-07" version="1">MDQLKLTQSDRNFFELVSRATFTNPFSPERVEIDRRISGRNDGASWPSIMPQAVKEVSTRLRTLEETAPIKIKDFAHPDRTIIEHALLFDAFHKYAYELDAIIDQQLASPDKSIDVPFAPELLAGLRTAGLARDRARRYLELFYQIRRAFFFIDKNLLGRSPSMQKLRMNLWNNIFTHDILHYERYLWDKMEDFSTLLLGPTGCGKGTAAAAIGQSGYIPFDENKNCFAESFTRTFIPINLSEYPESLIESELFGHTKGSFTGAVSAHEGIFSLCSPHGSIFLDEIGDISTQIQIKLLRVLQERTFSPVGNHEKLRFSGRVIAATNQNIDSLRSEGKFRDDFYYRLCSDCIAVPSLHQRIKEDPAELEQLVNRTIASIAGDNTEFAPMVMDVIKSRLGKHYAWPGNVRELEQCVRSVIIKRDYDGRHCQTANPNRSTIDISDEPDAQQLLARYCATLYDKYGTLGEVARRTALDRRTVKKHIERHCKNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT6</accession>
    <name>A0A1U9NJT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01358"/>
    <dbReference type="EnsemblBacteria" id="AQT68203">
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        <property type="gene ID" value="STSP2_01358"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01358"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="520" mass="56616" checksum="6481BA6E963B23D5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY7</accession>
    <name>A0A1U9NJY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH crp-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01209"/>
    <dbReference type="EnsemblBacteria" id="AQT68054">
        <property type="protein sequence ID" value="AQT68054"/>
        <property type="gene ID" value="STSP2_01209"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01209"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="33421" checksum="48250731D813EAAD" modified="2017-06-07" version="1">MNKVDHIRIPAQVFKLPLKGLCETCIMGLVYSFKKDGLRLSNAQMARLLNTSCRTVERAVSKLRKRGLIENKNDVQAVRCLVAVTDIESMELPTSGADTKSGVPTLSTDDMPGGTDVVVGQAPTSSTDTASGVPTCRGVNTDVHVDHKEERIEEEEEECSSGVRPVEFMDYWNAKDNLPRIRAFSDQRRSKFKARMAEGLFAENWQELIDMVSGSSFLTGKNDRNWRADIDWLLKNSTNYAKVLEGKYNNRNAQTKPSDSKDKNIPFTPEQEAEFLAKHTRKISEAEADKLFREIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK84</accession>
    <name>A0A1U9NK84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UvsW helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01078"/>
    <dbReference type="EnsemblBacteria" id="AQT67926">
        <property type="protein sequence ID" value="AQT67926"/>
        <property type="gene ID" value="STSP2_01078"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01078"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="233"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="580" mass="64107" checksum="AC1D6EDE23B0B9D8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC9</accession>
    <name>A0A1U9NKC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative superoxide reductase</fullName>
            <ecNumber evidence="7">1.15.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01130"/>
    <dbReference type="EnsemblBacteria" id="AQT67976">
        <property type="protein sequence ID" value="AQT67976"/>
        <property type="gene ID" value="STSP2_01130"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01130"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050605">
        <property type="term" value="F:superoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="15331" checksum="1932B10EFD4393F5" modified="2017-06-07" version="1">MTLVKSESKCENDIFCGINVPENTQDVESMTDLEKKHLPVITAPESVKKGETFEVTVEVGKYKEHPNEPKHHFEFMELYAGHTYLGRIDFMAQITEPVMKMHVTLDHIHGDLRAFAYCNLHGVWMGKAPIEITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD6</accession>
    <name>A0A1U9NKD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ORF">STSP2_01541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01541"/>
    <dbReference type="EnsemblBacteria" id="AQT68381">
        <property type="protein sequence ID" value="AQT68381"/>
        <property type="gene ID" value="STSP2_01541"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01541"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="3"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="356"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT68381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="51935" checksum="EB2DF6A904F3D822" modified="2017-06-07" version="1">MQTKTKIIATLGPACADENTITELVEQGVDMFRLNFSHGTLEEHAEMLSHVNRARANFPFSIGILADLCGPKIRITELPAGESVSSGDTVRIVSKLPRGTAARFGTNYPDFYSDVSIGQRVLIDDGQIELKITDKQNGEVICEVITGGDLKSRKGINLPDTDISTPAITERDWQCVNWAMDHGVDYLALSFVQSSDEITWLKNYLIEKGSLIRVVAKIEKPQAVENLQSIVNASDAVLVARGDLGVEMDLARVPLIQKQITRLCRKLGKPVIVATQMLQSMIKSPTATRAEVSDVANAIMDFTDAVMLSGETAVGEYPVKAIQTIEQIGEVTEAWLDSLNEPRPRIETHSDLSIDESIARSVAQIVDDMKAKMVVVWCQTGCTARLLSKARIDVPILALCADREMCREMSLHYGVIPVCRTRPRDFSQFADLANKVAQDNGWAKKDDTIILLPTGCLLRPNSTKAIVFHTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI5</accession>
    <name>A0A1U9NKI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68100">
        <property type="protein sequence ID" value="AQT68100"/>
        <property type="gene ID" value="STSP2_01255"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01255"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="271" mass="30491" checksum="210DED9443E29882" modified="2017-06-07" version="1">MKNKKAFTLIELLVVISIIALLLAIMMPSLSMVKRKAGTAVCLANTKNLSLAWYMYQEDNAGALIGGRSSKQTPWIKDPIDESGNALPVSRLWAESPPVTDDDEIRGIKAGYLYSYLEADGVYNCPSDNIRRGFDGTRVYVSYSIPRCLNGDFPKERKKFSQITRPSIRYNFVENADERNWNMGGSFPLGAPEYTGNDEWAWWGPLAVNHGDSSVLGFCDGHAEVHKWKDEFTKSRVDKLNDTDSNNYGIERPPEGQTEDIDYMARGWATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ6</accession>
    <name>A0A1U9NKJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="5" type="ORF">STSP2_01615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01615"/>
    <dbReference type="EnsemblBacteria" id="AQT68451">
        <property type="protein sequence ID" value="AQT68451"/>
        <property type="gene ID" value="STSP2_01615"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01615"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
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</entry>
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                <person name="Bunk B."/>
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</entry>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="593" mass="67328" checksum="837C7E2DF8C6CA3C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL92</accession>
    <name>A0A1U9NL92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
            <ecNumber evidence="10">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">miaB</name>
        <name evidence="10" type="ORF">STSP2_01663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01663"/>
    <dbReference type="EnsemblBacteria" id="AQT68498">
        <property type="protein sequence ID" value="AQT68498"/>
        <property type="gene ID" value="STSP2_01663"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01663"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="148"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="383"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="52271" checksum="AFCFA7123C5D11F6" modified="2017-06-07" version="1">MNKLDSSLVVTALRKKGFELCEKASQADVILINTCSVRKHAEDRVTSNLGHMKHLKKTRPKIVVAVVGCMAQRVGEDLLEHDAVNIVAGPSHIPQVPEMIMNALPKDVADAATGSKAISVTEKIRQKTDSQVSQELDDFELTYDSDENHIKHQAFVRAMRGCNNFCTYCIVPYVRGPETSRPPQAIIEQIKKLAQNGIQQITLLGQTIDAYHYEAGDKTYRLADLLEMVADIESIKWIHFITSHPGKFDTAIFQAMANNRKVTPYLHIPAQSGSDRILRAMNRGYTAQQYLDLISEARQIVPDVAIASDFIVGFPGETDEDYQATKNLITDAHFKNSFIFKYSPRPGTHATKRLEDNVPAEVKKQRNIELLELQNSIAEEDNKRFKGRTLEVLVEGLSPRPHLNNADTQTLADGSAATDESWQHPQLIARTAHDYIVVFNGPESLAGNFAKVEITDTAALTLFGRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF0</accession>
    <name>A0A1U9NLF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68739">
        <property type="protein sequence ID" value="AQT68739"/>
        <property type="gene ID" value="STSP2_01911"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01911"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40517" checksum="212E332CB24EADC4" modified="2017-06-07" version="1">MDDITLSKRDNIVRAIRFDWPEYIPMTFHINEACWEHYPAEFLEELMAEHPFLFPEAQRKQARPELEQQVPERVGRPHVDPWGCVWETAMDGIVGTVKEHPLVNWGAFASYVMPDPAVTDGKVGIDWGEISSAIEKAKSAGELTVGGLIHGHTFQRLVDLRGYENLLFDMFDGHVDLHRLIEMVERFNSEIVRRYVDLGVDMMCYAEDLGMQSGPMISPEMFRKYIGPVYERLMDPARQAGCIIHMHSDGCVRDLVDELLRDGVDAVNIQDLVNGIDWIRDNLTGRVCVDLDIDRQDITPHSTPANIDALIREEVERLGSREGGLMMIYGLYPGVPRENVVALADAMERYAFHYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK7</accession>
    <name>A0A1U9NLK7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01887"/>
    <dbReference type="EnsemblBacteria" id="AQT68715">
        <property type="protein sequence ID" value="AQT68715"/>
        <property type="gene ID" value="STSP2_01887"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01887"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="25410" checksum="A5BA02BC727B6AE1" modified="2017-06-07" version="1">MYSEDELISISALQHYAFCPRQCGLIHIEQTWLENMFTAKGRVLHEKVHESDNEVRSDLRIVRGLRIRSLRIGLVGQSDVVEFLRSETGIVLPGTEGLWQPFPVEYKRGKPKTDSSDSIQLCAQAMCLEEMLNVSIEKAAVFYGRPRKRFEVDVTDELREETVTVLKAIRTMLTTGQTPKAKYSRKCKSCSLYARCMPRTTGISKRIGAYISKAYEDPEEVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL6</accession>
    <name>A0A1U9NLL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ORF">STSP2_01546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01546"/>
    <dbReference type="EnsemblBacteria" id="AQT68386">
        <property type="protein sequence ID" value="AQT68386"/>
        <property type="gene ID" value="STSP2_01546"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01546"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="157"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25867" checksum="3D9690D2ADD60E1E" modified="2017-06-07" version="1">MEDRQIQQLEELIGYRFNDRSLLIESFTHSSHADHRLKSNERLEFLGDAVLDLVICKALFDQFPDYLEGDLTKIKSMLVSRKTCAKIASQLDLPQFTRVGKGMDQTRAMEGSIAAGQLEAIIAAIYLDGGYDAAAKFIINSFEPLIVKADAKQHHENYKSMLQQFAQCQFGQTPAYQLLDEKGPDHDKCFEVGVNISDHTFPAAWGNTKKEAEQKAALNALVELRQIKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL8</accession>
    <name>A0A1U9NLL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane lipoprotein YiaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yiaD_2</name>
        <name evidence="4" type="ORF">STSP2_02007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02007"/>
    <dbReference type="EnsemblBacteria" id="AQT68831">
        <property type="protein sequence ID" value="AQT68831"/>
        <property type="gene ID" value="STSP2_02007"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02007"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24535" checksum="A7AC613C5E8EFABB" modified="2017-06-07" version="1" precursor="true">MIKTFGKVAVLLILVVLVSGLTGCTDWKKKYNSLNVEHQNLQGLYEGCVTSLDAASADKARLSSQLNQSQKTIDQLQQEIEEMNVSPGEATGFGEGMDVAVDAEKGTITVTLPNAILFAPGKASLKKATSSELDHILNVLNERYAGKDVDVVGHTDSDPIRKSNWDDNWQLSAERALSVLRYLNKRDLDSENLRAVACGASRPVASNSTVAGKAKNRRVEIVVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN8</accession>
    <name>A0A1U9NLN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02027"/>
    <dbReference type="EnsemblBacteria" id="AQT68851">
        <property type="protein sequence ID" value="AQT68851"/>
        <property type="gene ID" value="STSP2_02027"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02027"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35616" checksum="65D1E989019F6DCD" modified="2017-06-07" version="1">MIKKVSIIAKNTFVETIRQPVYAVILAFALFLFVLSPSIAMYTLDEDIKLLREIGLSTLFLTGLFIAIFSASGAVAEEIDSKTITTVLSKPVRRPSFIIGKFLGVLSAVGLAHYIGTIAMFLSIRHGVLETASDTHDWTVITVAASVAVLALLLSAFFNYSYDWSFTSTAILLTALFSTIGMAFLFFIDRHWEFNPSHNGFTLFDLNASVLLFLAVMILIALAVMFSTRFNIVLTLIFCIVIFLVGLINGWAFGRFVDQHWWAQIGRMVFPDLQAFWISDAIYEDSSVPANYLGMTALYATLYTSGILAFAIALFQKRQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP0</accession>
    <name>A0A1U9NLP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cas2_2</name>
        <name evidence="9" type="synonym">cas2</name>
        <name evidence="11" type="ORF">STSP2_01889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01889"/>
    <dbReference type="EnsemblBacteria" id="AQT68717">
        <property type="protein sequence ID" value="AQT68717"/>
        <property type="gene ID" value="STSP2_01889"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01889"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10930" checksum="9C4B636CDB4F9242" modified="2017-06-07" version="1">MMVLVAYDVNTETKAGRGRLRHVAKLCENRGQRVQNSVFECLVDPAQWVELRQALVGVIAEDTDSLRFYFLGKNWKRRVEHVGAKPGYDPQGPMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX1</accession>
    <name>A0A1U9NLX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01748"/>
    <dbReference type="EnsemblBacteria" id="AQT68580">
        <property type="protein sequence ID" value="AQT68580"/>
        <property type="gene ID" value="STSP2_01748"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01748"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="4">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22857" checksum="8CE5E92517C2BCBF" modified="2017-06-07" version="1">MFWIFALILGVLTALLAKQKGRSVVGWFLIGFFLGLLGLILILVVSDKKSQEQREEQLKIEHRRLQEQLRQERMKNEQFRKYTQGRLDTHDDALGLDTKTAIRPNENLQHLIEGEQQAPVIPPDPSDRRPVESSAADNGNELGWYYEADGVQVGPVTLGQLRQYFTEGVIKDSTYVWHRSLVEWARADRVSQLAWGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY8</accession>
    <name>A0A1U9NLY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ahcY_2</name>
        <name evidence="4" type="synonym">ahcY</name>
        <name evidence="9" type="ORF">STSP2_01993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01993"/>
    <dbReference type="EnsemblBacteria" id="AQT68817">
        <property type="protein sequence ID" value="AQT68817"/>
        <property type="gene ID" value="STSP2_01993"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01993"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="232"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="261"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="52697" checksum="4B453FD65CDA823A" modified="2017-06-07" version="1">MTQQVESTFDYVVKDIELADFGRKEIEIAEKEMPGLIATREKYGKQKPLKGARVMGSLHMTIQTAVLIETLVELGADVRWASCNVFSTQDHAAAAIAARGIPVFAYKGESLEEYWDYTRRALTWPDGEGPDLIIDDGGDASLLMHRGYYAEEDPSTLDEPTDNKEMKLQNELLKGMLKETPDFWHKAAKRCQGVSEETTTGVHRLYQMKESGELLFPAINVNDSVTKSKFDNVYGCRESLVDAIKRATDVMVAGKMAMVCGFGDVGKGSAETLASHKARVAVSEIDPICALQAYMRGYSVMTVEDALPYADIYVTTTGNKDIITAEHMSKMKDQAIVCNIGHFDNEIQVDELNNWPGVKKTNIKFGVDQYTFEDGHSIYLLAEGRLVNLGCATGHPSFVMSNSFTNQVLATIDHWTNEKPIDVYRLSKKLDEEVARLHLDKLGAKMTVMSEEQADYIGFPVEGPYKSDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM33</accession>
    <name>A0A1U9NM33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68991">
        <property type="protein sequence ID" value="AQT68991"/>
        <property type="gene ID" value="STSP2_02169"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02169"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_3" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14580" checksum="4078C71244CA583F" modified="2017-06-07" version="1">MIDSISCVLAVDLKTYAFRHAAPEVKLLTGYDAAHLKGQGPGWFYSLMHPADADRLNAQYDTQTCKSETLPCIKYRLRCADGRYKWLHEDRAIIPAAADKNRPDLLVCRLSKHRHKASTPWNTALTVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM74</accession>
    <name>A0A1U9NM74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68690">
        <property type="protein sequence ID" value="AQT68690"/>
        <property type="gene ID" value="STSP2_01860"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01860"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387330" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16941" checksum="50B3D77514E8FDCD" modified="2017-06-07" version="1" precursor="true">MSARNTFTKSLFAMLVTAAPLLTGCIERKLTINTKPQGALVTLNDEQVGKSPVTVDFNWYGDYKVHIAREGYTTLDTHRVLEAPTHDKFPFDFFYGVLWPETIVDEYEWTFELEPYQVPDRNLLIESALDARQEALGSTFKNRTDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM80</accession>
    <name>A0A1U9NM80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisS</name>
        <name evidence="10" type="ORF">STSP2_02224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02224"/>
    <dbReference type="EnsemblBacteria" id="AQT69041">
        <property type="protein sequence ID" value="AQT69041"/>
        <property type="gene ID" value="STSP2_02224"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02224"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="434" mass="47982" checksum="D012141EDF49C4EB" modified="2017-06-07" version="1">MKIKAVKGTRDFYPQPMAVRNFIIDGWKEASLRNGFEEYDGPIFEYLKMYQVKSGDEIVEQLFNFEDRGGRHLAIRPEITPTLARMVNQQINALPRPIKWFSVPRLCRAERPQKGRLREFFQWNIDIIGVDSVLADAEVIFTSIDYLRGLGLDADDIKARISSRKLLAAFLKSAGIAEDQLESIYPVLDKKPKLPPEAFDELLLKSIPDSDIAEKVQKFMVLDDVAKIAAMSDGSEELEDAIAELAELFRILDNMGIADYCVFDPGIVRGLAYYTGVVFEVHDVVGELRALCGGGRYDNLLSDFGGPSVPATGMGMGDCVLEILLREKGLLKDDKLQTKKIDCFVAYASGEFAGEAVKLTAELRGLGVFTDFSYKGGNLGKQLKKAASAGASHTVIIGQEFADGGKYVLKTMATGDQAEVTPESLYEMVTRDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF8</accession>
    <name>A0A1U9NMF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68987">
        <property type="protein sequence ID" value="AQT68987"/>
        <property type="gene ID" value="STSP2_02165"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02165"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="306" mass="34087" checksum="68E496EEB4CF753E" modified="2017-06-07" version="1">MNVDCTGCNKTYTVPDSHAGKKVQCKMCGSIFTISPEQASDYENPEPADEQYTNDTPLPGFYTAALRDSWKVLFRCSNLKFMVFIFAAVAFKFFIGHVDLSATFPGFRLQMPIGQITTVIAYGCVFWCYMRLIEDTVYGVDEMPDSDDINSGFAFFGNVIKADYFFIVAFILSQLPFILLLTMLMSTPVPVPALVRITFLVAGFFLFPMMLLNLTASESPWLAFVPANTLRPIAKAFKPYTLVFLLVAAAVIAQILIPDYGRLDSPPMIIAASAFLGELIAVLLMLFAMRAVGLFGRHYDCYMPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_02216</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02216"/>
    <dbReference type="EnsemblBacteria" id="AQT69035">
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        <property type="gene ID" value="STSP2_02216"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012753016" evidence="1">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="484" mass="55230" checksum="758EE2CE8DA00EE5" modified="2017-06-07" version="1" precursor="true">MKKKTMMMVGLLIFSGVSFAAAEAREDAELYEWKNGDGMNGVFPHITVMAPGAGSDSEAGVGAMIPWADRLWVIGYVAHIRGENLGLFELKEDMSWRRHPASVTGTFANRFIHWESKQAIIGPHLIDEKGKVRTIEQLSKHRLTATCYHLEKPQAMVYFLTMEGLLFEVNVNTLEVKQLGDLTKKLYVEGIWPHWKGMWSAQGKLVVANNSYGEGEHMGKRHAGRLAEWDGEGEWKILEKNPFVEVSGQTRRGKYGGALFATGWDERSVIMRVLSNGKWKRYRLPKGNHTYDHGWNTEWMRIREAQTERYLMDVFGIFYEMPAIVYDNSVWGVKPICSHLRLIPDFCSWRGFFVMGSDQTEHNVGQPQSGLYFGNIDDLWQMGKPTGWGAVWRKTEIEAGETSDPFLMTGFDKKVLHLAVESEDPMTITVEVDFLGDGMWKEYETFNLEPGGYVHHEFPDAFSAHWVRLKTDGDCKATAQFMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR0</accession>
    <name>A0A1U9NMR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69024">
        <property type="protein sequence ID" value="AQT69024"/>
        <property type="gene ID" value="STSP2_02203"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02203"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="34747" checksum="23597664840F8180" modified="2017-06-07" version="1">MSNSHKLSLIIFAVVTLTLPAWGEDGPRVDRPERDWRAGERGPGDMESRIDQWLERLGESQPERARELRRLRESNPDQFMAEMRDEFGRQREGLGRGQGPERDMRGRGRGPGDEERGRGFRERARWHFERDQERYFEWLDENYPAEAERLRNLREKSPDDYFEEYRKSRKEYGGIMDMERRNPELAEVLMEDIKLQQERDALLKNLKTAGEEEKEQINAELRDIVERRFDLILQKKELRYKELLERLERLKNAVEKQKAQLEELNEQKQKNIEKRMKELLGQTESLDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS6</accession>
    <name>A0A1U9NMS6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdhC_2</name>
        <name evidence="9" type="ORF">STSP2_02441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02441"/>
    <dbReference type="EnsemblBacteria" id="AQT69252">
        <property type="protein sequence ID" value="AQT69252"/>
        <property type="gene ID" value="STSP2_02441"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02441"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="242"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="640" mass="67762" checksum="0CD6FC1F9B07676B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU4</accession>
    <name>A0A1U9NMU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4-mannooligosaccharide phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02422"/>
    <dbReference type="EnsemblBacteria" id="AQT69233">
        <property type="protein sequence ID" value="AQT69233"/>
        <property type="gene ID" value="STSP2_02422"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02422"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="35228" checksum="6B62E4B220F40CBC" modified="2017-06-07" version="1">MKHKPIVERFANNPILTTDDVPYKVETVHNAGVVKHQGKYIMLFRSHLDTGRSIIGIADSQDGIKFTVRPEPFMTPASEGIFAEYEAFGVEDPRINPLEGEYYITYSAYSPHGVRIGMARTRDFTTLERVAFITQADYRNTVIFPEKIGGKYVKLDRPHSDISPWSVWISYSPDLIHWGESRVIMKPVTYHWDEMKIGPGAPPIKTSRGWLNIYHGVFPTMSGSVYRLGVCMHALDDPARLIAVGDRWILQPEDPWEVSGYVDNVVFTCAAVPEPDGTVKIYWGGADKVMCGGTARIEELVDFCLDNPREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU7</accession>
    <name>A0A1U9NMU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">patA</name>
        <name evidence="3" type="ORF">STSP2_02342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02342"/>
    <dbReference type="EnsemblBacteria" id="AQT69155">
        <property type="protein sequence ID" value="AQT69155"/>
        <property type="gene ID" value="STSP2_02342"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02342"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="374" mass="41161" checksum="6994F73CD77E52D5" modified="2017-06-07" version="1">MDMQNVLADRTAAIDASGIRKVFALAASLKDPINLSIGLPDFDVPEPIKERAIKAVQDGANRYSQTNGDAELLTKLQGLVKEDYGWNDPEVLVTSGVSGALQLIFMSLINPGDEVIVPDPYFVIYKHMINMLGGKCVFVDTYPDFKLPAQKVADAITPKTKLIILNSPSNPTGTVYSDEDLRGIAEVAEKNGTIVMSDEIYDAFCYDEPCPSIANHYDKTILVKGFSKAYAMTGWRLGYAAVKPVLKPVLEEMIKIQQYTFVCAPTPFQKAAITAIDTDISGYVADYKVKRDLVYEGLKDDFELVKSGGAFYTFVKAPDSYDSATAFVEKAIENNVLIIPGNVFSEKDTHFRISYATTNDKIKQGLDILRSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU9</accession>
    <name>A0A1U9NMU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02418"/>
    <dbReference type="EnsemblBacteria" id="AQT69229">
        <property type="protein sequence ID" value="AQT69229"/>
        <property type="gene ID" value="STSP2_02418"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02418"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="97" mass="11049" checksum="7126B130604DEC76" modified="2017-06-07" version="1">MLVGTMVITINLPGIRSLKEKRKIVKSLVERLRNRFNFSVSEVAANESKLQAVIGLAMVSDDGVHIERQIDKVSEFVHADGRFFVSRIEREMFSVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY9</accession>
    <name>A0A1U9NMY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agaA_2</name>
        <name evidence="8" type="ORF">STSP2_02148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68970">
        <property type="protein sequence ID" value="AQT68970"/>
        <property type="gene ID" value="STSP2_02148"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02148"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013138079" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="310"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="405" mass="45129" checksum="ECE3ED8B5A54BC08" modified="2017-06-07" version="1">MRIFEVVCLSFAAFLFAGCGGSARPETPIMGWSSWNSYRININEELIKAQADSMVSSGMADAGYEYVNIDDGYFGGRDEDGKLFSHPEKFPNGMKAVADYIHSKGLKAGIYSDAGKDTCASKWDNDPKGYGVGLYGHTEQDLRLMLEEWGYDFMKVDWCGGEWLGLDEPSRYTEIGETIRSIREDVVYNVCRWQFPGEWFIDVADSWRISGDIQADFGSITRIIDLNADLWKYAGPGHVNDMDMLQVGRGMSYEEDKAHFSMWCMMASPLLAGNDLRSMTEETVEILTNAEMIAINQDPLVYQARRLRDDGEYELWARPLGAVDSGVVAVALLNRSKAEAVIGFEPAEVGLADTGYTVRDVWAHKFIKVDDESGLEFAVPAHGVVVLTLKGKAAEDNPFSPDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN26</accession>
    <name>A0A1U9NN26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02498"/>
    <dbReference type="EnsemblBacteria" id="AQT69309">
        <property type="protein sequence ID" value="AQT69309"/>
        <property type="gene ID" value="STSP2_02498"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02498"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25440" checksum="4E3A0ABCEA39CA2F" modified="2017-06-07" version="1">MDRRAFLKRIGTASAGVVFTAIAGGCGEEQMAQPVIVGRADYSRPKLRTHEAEPVEPTPKYSRRRAYPSNWYPEKDKEKKWRAVIVHHSATGTGCASVFHQWHKYQLGWDGIGYDFVIGNGSGSGDGEVEVTYRWRTQVTGAHAKAANNWANRDAIGVCLVGNFNDSRPTSNQLRSLAKLTDFLQRRYGISDSNVFGHRDTPRLVKATDCPGRHFPWRTFQNMLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN46</accession>
    <name>A0A1U9NN46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF_3</name>
        <name evidence="14" type="ORF">STSP2_02351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02351"/>
    <dbReference type="EnsemblBacteria" id="AQT69164">
        <property type="protein sequence ID" value="AQT69164"/>
        <property type="gene ID" value="STSP2_02351"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02351"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT69164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="414" mass="43717" checksum="13102EE69A6EE15D" modified="2017-06-07" version="1" precursor="true">MSRRRVVITGLGCVTSLASSSDKLFASLCEGKSGISKIECFDTAEYPVKFGGEVKDFEISEWISTREGRRMDRFTQMALASAIQAVEDSGLKFEGEDAERTSVIIGSGIGGLKEIEEQHIRLLEKGPRKVSPFCVPKLMGNAASGCVSIHYGLKGPNMCVVTACASAGNAIGEAFYNVLSGRSDISVTGGSEAALTPIGLASFCSLKSLSTRNDDPTNASRPFDKDRDGFVLSEGAGIVVIEEYEHAKKRGADIYCELLGYGATGDAHHITAPEPEGLGAGEAMKLALKDSGLNPGQIDYINAHGTSTQLNDVAESKAIRKVFGDDAYNLAVSSTKSCLGHLLGASGGVELIATSKAIKESVIPPTANLENVDPECDVKMDFVPKDAREKEVNYAMSNSLGFGGHNCSLVVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN64</accession>
    <name>A0A1U9NN64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69351">
        <property type="protein sequence ID" value="AQT69351"/>
        <property type="gene ID" value="STSP2_02540"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02540"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26053" checksum="AB1FAEA9629E7564" modified="2017-06-07" version="1">MRTANPALKQNTFEVAVPSDRPMSITGTAVKTGVLLILAVITASWTWGMAAEKSVQATMPWMWTGVLGGVVFAIATVIKPKWAPLTAPFYALLQGLFLGAISAAYSQAYQGIVPQAVLLTFGVLACMLVAYVSGIVKATENFKLGVVSATGAIGLVYLVSIIANAFGGQIPYIHGSGIIGIGFSIFVVVIASLNLVLDFDFIERGAVNGAPKYMEWYGAFGLMVTLVWLYIEILRLLAKLNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN84</accession>
    <name>A0A1U9NN84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02560"/>
    <dbReference type="EnsemblBacteria" id="AQT69371">
        <property type="protein sequence ID" value="AQT69371"/>
        <property type="gene ID" value="STSP2_02560"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02560"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13077" checksum="DD6740B6D37E21F0" modified="2017-06-07" version="1">MVGSKILNLNSIDGVTVASFNVTSICGVTDVEELSTELRQYVDSVKPQKLIIDFEGVKFFSSQMLGLLVDIWRRLGEYGGVFMISGTNPQLGRVFKITNLDKLFKLYPDRQQALNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA7</accession>
    <name>A0A1U9NNA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69100">
        <property type="protein sequence ID" value="AQT69100"/>
        <property type="gene ID" value="STSP2_02287"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02287"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="21317" checksum="6AB4CA85950543BE" modified="2017-06-07" version="1">MNQPASNGPTISFDEFGPLEIRPQPGRNYCHTDHPKRLPATYTRKHGVQHWLAFYDVHQKKLWGYVRPRKRHQEFLEVLKLTRKKYPANQRIHLILDNFSPHRKDKVLRYCRENNIHLIWTPTNASWLNPIECQFTHVKEFVIRGTNYQNHHELKTALNRYVAYRNKKNQQKLNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC1</accession>
    <name>A0A1U9NNC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arogenate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tyrC</name>
        <name evidence="2" type="ORF">STSP2_02194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.43" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02194"/>
    <dbReference type="EnsemblBacteria" id="AQT69016">
        <property type="protein sequence ID" value="AQT69016"/>
        <property type="gene ID" value="STSP2_02194"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02194"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047794">
        <property type="term" value="F:cyclohexadienyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31735" checksum="004F5873D1320F20" modified="2017-06-07" version="1">MKNLQQITVIGMGLLGGSVTLSILRSLNGVKAVGYSHRESTRNRARELCIASEIADDMNEAVKGADIVILATPIYTFERIFKEIASSIKPGAIITDVGSTKVLPHRWGEKIFSKDVAYVGSHPIAGSEKSGVDYARDDLLVGAKCIVTRKKKTNEEAVKTLVQFWAALGSRVSVMSPAEHDRIFGSVSHLPHVVAVALVNASNFEQLKYAGKGFIDTSRIASGPSNVWSDILLSNTSNTARGIDRMIKQLSTIKEAIEKDDQRKLANLLEKARTKRAELIDYKISKKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE9</accession>
    <name>A0A1U9NNE9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02447"/>
    <dbReference type="EnsemblBacteria" id="AQT69258">
        <property type="protein sequence ID" value="AQT69258"/>
        <property type="gene ID" value="STSP2_02447"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02447"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16290" checksum="74D2CA9F34C82C06" modified="2017-06-07" version="1">MKPVNSDTELLQTRKHIHPNCIVCNKANPKGLNINYVLTEDGSGVTAVFDCDEQYEGYPGIIHGGVIASIFDGAMGNCMFAHGHSAVTVELTTRFRHPVQTGKCARITARITRVSRPLFLLEAELIQDCQVKATARAKFYEQPELQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ1</accession>
    <name>A0A1U9NNJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligosaccharide biosynthesis protein Alg14 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02649"/>
    <dbReference type="EnsemblBacteria" id="AQT69459">
        <property type="protein sequence ID" value="AQT69459"/>
        <property type="gene ID" value="STSP2_02649"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02649"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="PTHR12154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15867" checksum="D4C7627EA1EC0A15" modified="2017-06-07" version="1">MSQLLILLNCWDFQQKPDLYVTTRKQTAQPLESRGPTYCIGECNRRKPVRSLLVLLKTLSLALRKRPDVIITTGSMPLALFCGWSKLLGAKIVWIDSITNIEKLSVSGRFVRHFADLMLVQWPELTNRYTKAEYVGAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ2</accession>
    <name>A0A1U9NNQ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agaA_3</name>
        <name evidence="8" type="ORF">STSP2_02617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02617"/>
    <dbReference type="EnsemblBacteria" id="AQT69427">
        <property type="protein sequence ID" value="AQT69427"/>
        <property type="gene ID" value="STSP2_02617"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02617"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364435" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="7">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="666" mass="73484" checksum="51298EB1C0B51796" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT8</accession>
    <name>A0A1U9NNT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02363"/>
    <dbReference type="EnsemblBacteria" id="AQT69176">
        <property type="protein sequence ID" value="AQT69176"/>
        <property type="gene ID" value="STSP2_02363"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02363"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="1">
        <location>
            <begin position="391"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134125" checksum="1569645687F9DCA9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU6</accession>
    <name>A0A1U9NNU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">epsF_4</name>
        <name evidence="12" type="ORF">STSP2_02762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02762"/>
    <dbReference type="EnsemblBacteria" id="AQT69569">
        <property type="protein sequence ID" value="AQT69569"/>
        <property type="gene ID" value="STSP2_02762"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02762"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="260"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="391" mass="43038" checksum="FB68B68F8D3FD30D" modified="2017-06-07" version="1">MATLEQTLNQTEDTSQVISTSSAGTDAAQDQPQTTMDKLNSFSIEAGPNRKDILNFTNQLSVMVKAGMSLQESLESIAEQTEKRKFKEVLMDVKNRIEGGQSFSQALAEHDGIFNELYINMVAAAEISGSLSSMLEKLAGYLDQEAETRSQVMGAMMYPIIIGVMAVTCVTFLLIFVLPKFLAVFAGKEQYLPGPTKIIMAISGTMRGYWYVIFPGIAAAIGGFHYFTKTPTGKVWWDKVKLKMPLVKTLCRSLYITRGLHTMGVLTNAGVPVLDTLNITAKISGNIYFKRMWQDVHENVRQGKKIAQSLDGYDLLPSSVVQMLRSGEDSGSLGTVLRDVSEFYGRELKTVIKMVTSMIEPIMIVVMGVIVGFIAMSIILPIFKMSNVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX5</accession>
    <name>A0A1U9NNX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">M6 family metalloprotease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69545">
        <property type="protein sequence ID" value="AQT69545"/>
        <property type="gene ID" value="STSP2_02737"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02737"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="418" mass="47330" checksum="FA2AA2201A88D4E3" modified="2017-06-07" version="1">MYQASSIILFVFNLLLISAGPIRGEQLIVRETIPPVVTSQRVQSTPAATMKCPNGRTVEAHIFFCDTSDAPGDPNLATRQYFENTTRNYIFGTGENGIQSWFDYYSHGKIRFRYVVHPDWLRLPKTQEYYLKPLPGKPKSWNWPEWIADVTDTLLAAGYEHTDTRLPIIINPPNSSKVFMGGGAIHALKVNAPNARFLHLGGGIYLDDSDRYAYLRNEGVVIHEIGHFLGLPDLYNGTRGFNSWDMMGGAYDAAGFCGWHLHCLDWLDKSRKRYVVSTGSKPQTMTLTALSKGEGVFMMVIPDNPAKPEQLRSPWIIELNQPVLEREKNNGGPDKHILLPEATGVLVYRLEPDKNPVLQSYFREIPQDKTKRKPRPDYLNKTLYGPGDIFKNPEAPFKMRVLSIKDKTANIRLIIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ1</accession>
    <name>A0A1U9NNZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nif-specific regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nifA</name>
        <name evidence="8" type="ORF">STSP2_02758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02758"/>
    <dbReference type="EnsemblBacteria" id="AQT69565">
        <property type="protein sequence ID" value="AQT69565"/>
        <property type="gene ID" value="STSP2_02758"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02758"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="198"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="57914" checksum="F0A7BF8D5D309EE4" modified="2017-06-07" version="1">MAKKATKDIELLSQIANVFSEAIDLESSLKAILKWLDQQLKLRRGTITLFDPDSETINIEVAHGISDANKKQVTYKPGEGITGTVVQTGKEVIVPDIRKDPRFLYKTRTKPELSTERRAFFCLPIKLEGNTIGTISVDKKSQSGDDLESETYFLNVISTMIAQAVRLNRRLQSERKGLTSENERLRSELRSRFKIDNMVGTSNAMQQVYRLVEQVANSNATVLIRGESGTGKDLVAHAVHYNSLRADKPFVKVNCTALPETLLESELFGHEKGAFTGAVERKKGRFEMAHGGTIFLDEIGDFSLNLQVKLLRVIQFKEFERLGGTETIKTNVRIVVATHKDLEQEIREGLFREDLYYRINVFPIYLPPLRDRKDDVMLLADYFLEKYAPENNKSISRISTPAIKMLTSYHWPGNIRELENCIERAVLVCNEDVIRSEHLPPSLQMVKPNAPAEKNLTLPEIIENKERELIVDALKKTNGNQRQAARDLGVTERILGYKIRKYDILPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ5</accession>
    <name>A0A1U9NNZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purE_2</name>
        <name evidence="3" type="synonym">purE</name>
        <name evidence="7" type="ORF">STSP2_02867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02867"/>
    <dbReference type="EnsemblBacteria" id="AQT69672">
        <property type="protein sequence ID" value="AQT69672"/>
        <property type="gene ID" value="STSP2_02867"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02867"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="17986" checksum="E69AC026983A4D0C" modified="2017-06-07" version="1">MTKPKAAIIMGSDSDLPVMQKAHEIFRDFEVPCELTVVSAHRTPDRLFEFARGAHERGIEVIIAGAGGAAHLPGMVAAISPLPVIGVPIKSSNSIDGWDSVLSILQMPGGVPVATVALDGAKNAGLLAVQMLSIGDAGLREKMLEYKKQLKESVMEKVSRLESKMGNQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ8</accession>
    <name>A0A1U9NNZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02519"/>
    <dbReference type="EnsemblBacteria" id="AQT69330">
        <property type="protein sequence ID" value="AQT69330"/>
        <property type="gene ID" value="STSP2_02519"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02519"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="21098" checksum="318294A4F43CA837" modified="2017-06-07" version="1">MLPWLIIGGVVVLLIIFLIAAYNSLVRLRNQVDNAWSQIDVQLKRRHDLIPNLVETAKGYMKHERETFEAITEARSKAMGANNVSEASKAEGQLNDALSKFMLVVENYPDLKANQNFLSLQETLTSTENKIAFARQGYNDQAMFFNNKIEMFPSNIIAGMFNFKKRDYFEIENEAERQAPKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP06</accession>
    <name>A0A1U9NP06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atsA_20</name>
        <name evidence="3" type="ORF">STSP2_02877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69682">
        <property type="protein sequence ID" value="AQT69682"/>
        <property type="gene ID" value="STSP2_02877"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02877"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="483" mass="53639" checksum="A3703E3306880BEC" modified="2017-06-07" version="1">MDRRAFLKVSGAAALGVGALRGVSFGAERKAAGPNVVMIYLDDSGYGDYEHNGNPTIKTPNIRRMVQEGVSFSQFYVTSPACSASRFSLLTGRYPGRSGLGRWVVGPGSKMHIHPKEVTLADGLKSKGYTTGIFGKWHLGNPNGRNGMTRDALPLAHGFDEWMGTNVSHDYGNAKLMESDASGEDPVKGYRTLARNLPSNTEVCDSLTKRTTEGALRFIEKNSSRPFFAYVAYNMPHLGIHASDEFKGKSRRGLLGDVMMEIDDGVGRIREMLEKAGVSENTLVVFASDNGPWVKFRDTKDHPRYGEARMHVGYAYPFRDGKGSTWEGGHRVPGIFCWPGKIPGNRIVQEPASTLDVLPTVFAMAGVEVPEDRTIDGRDIRGLLMPGEYAWEEGPFTFYYNYWDNKPSAIRKGAWKLHIRIGSQTGNNYGFSASREKPLLFNVEEDLGERIDRAAERPELVKEMLGELEAFEKQLKQEGSFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP15</accession>
    <name>A0A1U9NP15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69639">
        <property type="protein sequence ID" value="AQT69639"/>
        <property type="gene ID" value="STSP2_02833"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02833"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20347" checksum="4D597405C7163D77" modified="2017-06-07" version="1">MLIELIMVVVVIGLMTAVASIALTGRIGPAKLQSQARDLIKTFEMARDGAARSENRYAIRIDFIDQTYTLREIPPEGMEKSLSENPIIKQVELTPSQAQFDYVYFDDGTDSRFPGPGRDATSATFLAGRAGWQNGGKIVLIDQDGNPWSIIVNRIGRNIELVEGDSEIFENVLKPRSRTELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP20</accession>
    <name>A0A1U9NP20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ORF">STSP2_02675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02675"/>
    <dbReference type="EnsemblBacteria" id="AQT69484">
        <property type="protein sequence ID" value="AQT69484"/>
        <property type="gene ID" value="STSP2_02675"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02675"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="211"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="57756" checksum="3F1885D34507797C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP32</accession>
    <name>A0A1U9NP32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftnA</name>
        <name evidence="3" type="ORF">STSP2_02685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02685"/>
    <dbReference type="EnsemblBacteria" id="AQT69494">
        <property type="protein sequence ID" value="AQT69494"/>
        <property type="gene ID" value="STSP2_02685"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02685"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19550" checksum="3D783D42D39EACBD" modified="2017-06-07" version="1">MVPEKIEKALNSQINAELYSGYMYLSMSAYFEGMDLDGFANWMRVQAQEEQSHAMKIYDFVNFRGGKVNLTAIDGPPTEWASPLAVLEATLEHEQKVTGLINKLVKLAREEDDYATENFLQWFVDEQVEEEDNAGKLVSQLKLVEGNPQALFMMDRELGQRTFTPEEAEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP42</accession>
    <name>A0A1U9NP42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nqrE</name>
        <name evidence="8" type="synonym">rnfA</name>
        <name evidence="9" type="ORF">STSP2_02679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02679"/>
    <dbReference type="EnsemblBacteria" id="AQT69488">
        <property type="protein sequence ID" value="AQT69488"/>
        <property type="gene ID" value="STSP2_02679"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02679"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21407" checksum="543E569EDD5194D3" modified="2017-06-07" version="1">MEELRTALTVGFAAIFTNNILLVYFLGMCPFTSVSREVKTAMGLGFAVIFVMTCTSLLNWVAYHYVLVPLELEFFRFIMFIIVIAAFVQFVEMVIERFSPVLYANLGIFLPLITVNCAILGVSLFMVIRDYSFIVTIAYGFGSGIGWLLAILAMAGIRQRMNTANVPEGLQGPGITLIIAGLMALAFIGFTGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP61</accession>
    <name>A0A1U9NP61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02780"/>
    <dbReference type="EnsemblBacteria" id="AQT69587">
        <property type="protein sequence ID" value="AQT69587"/>
        <property type="gene ID" value="STSP2_02780"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02780"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="346" mass="38959" checksum="E5C729B721F9B890" modified="2017-06-07" version="1">MFRKKQSIGLDTNTSGTTLVLMRRRKNGYKLKALAQADHSESFVDSFDPLDHIRKCFIQTRSKPRRSQRVACGLNGTEVTVNRFDFPAMSEQELEYAIHYEAGEVCPFNIDRCVVDFCLAEDQKNKKPLEKRERLRGITVVAKKQAIEEKISTLKRLGLNCRLVDVNGLALLNCIDELEYKGEGRAYAAVSLNERSTTVAVKLADGTCITRELQGGIEMICRNISQAYQMERSHVRQRFDHASPLDQQFQEMLLTGSREVLAQIDETLKFSTSQGTNKQMAIVYLCGPRGITDAFGIPLNNMLPYEVEIWNPMDRLFISKRVSRTGIAGKLRGSAAIALGLAMRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP83</accession>
    <name>A0A1U9NP83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YlmA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ylmA_2</name>
        <name evidence="5" type="ORF">STSP2_02949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02949"/>
    <dbReference type="EnsemblBacteria" id="AQT69752">
        <property type="protein sequence ID" value="AQT69752"/>
        <property type="gene ID" value="STSP2_02949"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02949"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29248" checksum="9563386F01E1C600" modified="2017-06-07" version="1">MQAPDKAKDCLTLKDISVTAGPKPILQIDSLHLHEREFTGVIGANGAGKSTLLKLCCGLVLPHQGSVKLCGREIASTPAWKRPRALKHIGYVPQSTEYNPDLPFTALEVVLMGITGTKPLTAPLTKNDREIARRWLDELGLDEYRNRTFRSLSGGEQQKTMIAAAMASDPKLLLLDEPGASLDFGWKEQLVAILEKLNDISHAATIFVSHEANLLPACCKRLVLLRSGRIAADGSTIDVLNSDHFRAVYGRNIKVTNLAGRWHAAANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC6</accession>
    <name>A0A1U9NPC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69771">
        <property type="protein sequence ID" value="AQT69771"/>
        <property type="gene ID" value="STSP2_02968"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02968"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17182" checksum="80B919E563D825A0" modified="2017-06-07" version="1">MTAMRIKSGRELEAGYTLAEVIVVVMFIGIFAAVAIPRIDFGIVRKHAAETAAHKIVTDLRRTRHMAISNASENSQGYRMDFVSVDGRAGYRLIDLSNNSKVDEQFVSDEISCSGAGSYDFGPLGNLKAGSDDSLEVAADGKTFSVAIVRSTGAVKCTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ0</accession>
    <name>A0A1U9NPJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">STSP2_02952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02952"/>
    <dbReference type="EnsemblBacteria" id="AQT69755">
        <property type="protein sequence ID" value="AQT69755"/>
        <property type="gene ID" value="STSP2_02952"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02952"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="1-deoxy-D-xylulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26240" checksum="B43E6D158AD80EE8" modified="2017-06-07" version="1">MALLNVNIDHVATIRQARLTDEPDPAWAAMQCELAGANGITVHLRQDRRHINDRDVRVLKETVASKFNLEMCMADEMVKIAEDIVPDQVTLVPEKRRELTTEGGLDCVKTKEQLAKVTKRLQKKGILVSAFIAPEESQILAAADCGCEAVELHTGMYANAVKDKKVESTLNDLRDAYDIAVTSGLVVHAGHGLTYRNIEPVTAIQGLCEFNIGHSIVSRAVIVGMRQATEEMIKLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT4</accession>
    <name>A0A1U9NPT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69933">
        <property type="protein sequence ID" value="AQT69933"/>
        <property type="gene ID" value="STSP2_03133"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03133"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8814" checksum="DD5890C5988F467D" modified="2017-06-07" version="1">MSEVVFVSGDGHDDSDEKLRRLSRKLENASNICEELGERIDRLEEVLLEWRKCGVPIMGAELMAKTDKVLGLRKRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW5</accession>
    <name>A0A1U9NPW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">STSP2_03063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03063"/>
    <dbReference type="EnsemblBacteria" id="AQT69865">
        <property type="protein sequence ID" value="AQT69865"/>
        <property type="gene ID" value="STSP2_03063"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03063"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14193" checksum="95DC3AC119BED1AC" modified="2017-06-07" version="1">MGLKIYKSGQGYHTRLWTGISIFALVATGCYVLYGQLAQAGILVQTLVPMAICVAFAGGLFWLLNNRKVADFLISAEGEIKKVSWSSRREIVSSTMVVISVVIIMMILLFLADFVFRYVLDQVFNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX4</accession>
    <name>A0A1U9NPX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02965"/>
    <dbReference type="EnsemblBacteria" id="AQT69768">
        <property type="protein sequence ID" value="AQT69768"/>
        <property type="gene ID" value="STSP2_02965"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02965"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="507" mass="56123" checksum="24EA8970EF633964" modified="2017-06-07" version="1" precursor="true">MLGSSTYLGIDISQTQVSIAHIKKVDDGIRLLKAGSAPVPEGVVKEQSIEDPRVLAKTVRGLLKKHGVRERKAVVSLFAGAGLAQIIDLPEDVPANVAGYVRSQIKNSALLSGKQSHYDFCRLANARSGSSGRVLVGATNAERINRLLKTIRLAKVEPVGVEFPTIAWCRSIYQKVIKPRYSQNVLAVHVRDSQIFFCVFHKHELDFARCVDVNREEGADAVEQCVNEISSIIQYYELDSSLDMRAGWEVIINAGKGCLDGAALRDSLDESLDVNTFLCSDSSFASDTPAQSSKVESASLTAIGLAMKYAHRSICDLEINLVPERDRDIAKLKDVGLKVGNCTAAMLLAMILFSGYQVAQTNETHRAMEERREKSPSADIEKLVRRHRFLNDHLGVLQEKEQAMNEAMKASRTPAYAKILEEISEHTPQNLCITSLYCDDDDTMIIKGDSLDYQSVHYFARLLQESSLFETAAVAETNKHERIKNLLSYRMECKISGREGLQANASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ28</accession>
    <name>A0A1U9NQ28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="11" type="ORF">STSP2_03032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03032"/>
    <dbReference type="EnsemblBacteria" id="AQT69834">
        <property type="protein sequence ID" value="AQT69834"/>
        <property type="gene ID" value="STSP2_03032"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03032"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="447" mass="49476" checksum="750417708406A391" modified="2017-06-07" version="1">MLRSAINVFKIPDLRNKILFTIALLCIYRLGYHIPVPGFDTSAISDISRDAESPLGRVTEYLQMFSGGRLDRTSLFGLGIMPYISASIILMLLGEVLPALRKLRQEGPAGYKKIQEYTRYLTVPLCIVQAFMIMQLYKDYTYPGVAKQAMFMGVVGMTAGTLFLMWLGEQIDEYGIGNGISLLIMGGIVARMPGAIMTFAENTTMSLNAPEGMNGPHDIIFVIGAFIFVVAGAILITQGQRRIPIQQAKQMRGRRMYGGQRHYLPLRVNHGGVMPIIFASSLMMFPPVLFQQLGKIEGWGAAMARINEAFSPTAYTYNVVYVLLIFAFAYFWTTVQFQPKDMAKRLRDSGSFIPGLRPGHRTAEYLETVMVRITYFGAAFLAFIAVVPTVCAGLMGIPYTVAMFLGGTGLLITVSVSLDLVQKIESSLIMHNYEGFSDAGRIKGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ79</accession>
    <name>A0A1U9NQ79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhageMetallopep domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69937">
        <property type="protein sequence ID" value="AQT69937"/>
        <property type="gene ID" value="STSP2_03137"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03137"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMetallopep" evidence="1">
        <location>
            <begin position="65"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="278" mass="31357" checksum="441B8BB5C1FB2F02" modified="2017-06-07" version="1">MTTVKNNRTGAERLNDLVERAQQYGLTGQFGAEQYRRIIDSGLDEYPKNVPYFETVGWHDSGKSMFIANERLRRIAQNLIDCVPEHRHLQEAKILLLVRSDDGIRRKLEGGKKAVLGKGVEAREVDFVVWISGDWLDRLGVTKERGCEAEFDGAGLLGGWEPMQRTAALIDHELLHCGAKILGEFVRRKDLEKKVERLGAAFIEVCEDIVCEATDSVLVRFYDVDGGFKFCMRKHDVEEFHGVACRHGSWNRQLGRLVDAIVHPDPQKELPLGDGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ3</accession>
    <name>A0A1U9NQJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease YhbU</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbU</name>
        <name evidence="2" type="ORF">STSP2_03406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03406"/>
    <dbReference type="EnsemblBacteria" id="AQT70201">
        <property type="protein sequence ID" value="AQT70201"/>
        <property type="gene ID" value="STSP2_03406"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03406"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="323"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="45508" checksum="DAE706381807C9EC" modified="2017-06-07" version="1">MTTNSKNKAELLAPAGNLEKLKWACEYGADAVYFGTEFGSLRSFAGNFSFEDANSGLQYLHDRGKRGYITLNIYPFSDEYERIIDTARKLDEMNADALIVADLGVFAELRKLGLNADLHISTQANTVSAQTALAYAELGAKRVNLARELSCEQIIDLNDRTAGKIETEVFIHGSVCFSYSGRCAISDYLTGFAANRGECKHPCRWQYALVEEKRPGEYMPVYEDERGLYFFNSKELALFEYVHQLADAGVASFKIEGRMKAIHYIATVVSFYRQVLDGRTFTWQEGMELLGRVPNRGYSRGFMKGGITPDDYSVGQSLSQANSRFVANALHEKKDGKTVLEVRNKVHAGDELEVLRPDGTLSKLKLPAPLLTSRGEKVEFANNSQFVLIDAELPAYSILRRIENCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK1</accession>
    <name>A0A1U9NQK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03394"/>
    <dbReference type="EnsemblBacteria" id="AQT70189">
        <property type="protein sequence ID" value="AQT70189"/>
        <property type="gene ID" value="STSP2_03394"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03394"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="247"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="497" mass="53555" checksum="4DF2A4E051297235" modified="2017-06-07" version="1">MLSENPAPIERDAQGSKAVKSARSTQQPTSRPDPKSELTLRLAGLAVGLGFWVAGVLPVFAWCGPVGMLPVLYLATTEKARSKQLAVAGLYAGLAYTIPQLVALRMHVITSLILLAYMVILMIVLCIGSGFALRQKGIRAAFLLAAWFALFDWVAVHALPIWGAAQSFARPWSLYNEFIAFTSVTGIHGIMFIEGLLAGLAVKMIAEPNKRRFAMTAAATILVIAAADLAILTRPPVDQFTIGAVGWTVNDSAAEQGCQTEEAFKNIYAAGVRLAAQQGARLVVSGEMGFYIYKNTRAEWLARFAEVARSNDVYLAVGYYDTGIDSNRFMFIDPAGEVLCEYVKTYQTPFEPGIPGTGDLQIIEIDGVKVGGMICQDDNFTDLTRFYARQGVGVVVLPTADWQSVKKPHMQSSIARAVEGGYAVVRGAANGESAVINSDGDMLARMDHFDQGPGHVVATVDIHNGGTFYGRTGEWLVALSAALLIVASVRHLLTQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN3</accession>
    <name>A0A1U9NQN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrR</name>
        <name evidence="6" type="ORF">STSP2_03448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03448"/>
    <dbReference type="EnsemblBacteria" id="AQT70242">
        <property type="protein sequence ID" value="AQT70242"/>
        <property type="gene ID" value="STSP2_03448"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03448"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19269" checksum="63DB23C06515D472" modified="2017-06-07" version="1">MEIILDAKQIQDALKELASQIASSGADPNEIVVVGIRSRGEILAQRLNAILSDMLSHEIPCGTLDITLYRDDFNQPRDNGYPTVQSTEIPFDINSRIVILVDDVIHTGRSARAALDALIDLGRPKVVRLAVLIDRGQRELPIQADYLGHKLDVPANKAVEVSLAEIDENEQVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS0</accession>
    <name>A0A1U9NQS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03465"/>
    <dbReference type="EnsemblBacteria" id="AQT70259">
        <property type="protein sequence ID" value="AQT70259"/>
        <property type="gene ID" value="STSP2_03465"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03465"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346513" evidence="1">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="466" mass="52573" checksum="6CF48027A657D0B1" modified="2017-06-07" version="1" precursor="true">MKSMLISSIVVVAAWLQVVACSAAELPAPGVGLTIYNDDFAVVKERREMEFEQGVNEVKFTDVASSIDATSVNFKCLSDLDAVSILEQNYEYDLVNTASLLDRYIDKEVVVQIAGSGADVGTKVRGILSASLGQDLIIRDADTGEMEIINRSSIERIALVKMPRDLVTKPTLVWLADSKVAGEELCQVTYTAGNIGWKADYSAVLNADETKLDLTGWVTINNRSGAAYEDAVIKLIAGDVRRVQEQPQQPRRVYDRAVMMEAKAAGFEEKPFMEYHLYTLGRPSTIKDKQVKQIEFIEPAADVPAEKVFVYEWQKKPEKVQVKIEFENTEENNLGIALPKGKVRVFKKDPADGMLEFVGEDMIDHTAKKEELSLYIGDAFDIVPEHKMVDHKVGRRQRTEVHEIELRNRKDEDAVVNVDHKISPWMNWKVSSEMDWQKEDSTTARFEVPVKADSTVTFRYTVYMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU2</accession>
    <name>A0A1U9NQU2_9BACT</name>
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        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="5" type="primary">hsdM</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="191343">
        <property type="entry name" value="M.PbaBD1III"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70088">
        <property type="protein sequence ID" value="AQT70088"/>
        <property type="gene ID" value="STSP2_03290"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03290"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="815" mass="92190" checksum="453F9A44DD2322D5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY2</accession>
    <name>A0A1U9NQY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagO_3</name>
        <name evidence="7" type="ORF">STSP2_03537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03537"/>
    <dbReference type="EnsemblBacteria" id="AQT70331">
        <property type="protein sequence ID" value="AQT70331"/>
        <property type="gene ID" value="STSP2_03537"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03537"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="382" mass="41429" checksum="699CEF86B9200D00" modified="2017-06-07" version="1">MFLDNAIGDDRPLSWAVRFWPVLVCALVAGLAATWLCKKVAIRFNIVDRPDETVKTHKEPVAYLGGIGMMVGFVVGVIGGIWLIQGEECFRTCLRWLLGVLAGGAIACFTGVVDDLFDITPKKKLFGQLIASLGLVAAGILPAWESLVSPLGLDFPHWFEVAVAVPIVIVFVLGATNSLNLLDGLDGLCAGVTAIIALAMLLLAVHLGTWEFSETGDPVRMIVCLAILGGILGFLPFNRHPAKIFMGDAGSMLLGFVVAALMIMFAESTARWWLASIVVFGLPILDTATALVRRYLNDRPLMVSDRGHLYDQLMDRGLGLQKTVTLSYVLAAVYAVIGLIMSQIRTRYALAVYVLVFAVSGYVVWKKGFLKMEGLRGAVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ3</accession>
    <name>A0A1U9NQZ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70040">
        <property type="protein sequence ID" value="AQT70040"/>
        <property type="gene ID" value="STSP2_03242"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03242"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572553" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="986" mass="107186" checksum="4C28B55F20344BD7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR57</accession>
    <name>A0A1U9NR57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTP-binding protein YjiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjiA</name>
        <name evidence="3" type="ORF">STSP2_03207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03207"/>
    <dbReference type="EnsemblBacteria" id="AQT70006">
        <property type="protein sequence ID" value="AQT70006"/>
        <property type="gene ID" value="STSP2_03207"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03207"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="217"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="32695" checksum="35C11ECE5B81FC5E" modified="2017-06-07" version="1">MSDRIDVYILTGYLGAGKTTVLNHLLEDGGLKDREVALVINEFGKVGVDGSRVRDGDYAKFEINKGSIFCICTKTEMLKAFTEIAENARPDAVIVEATGIAEVRDFENILAVPELLAKFQVRANVCVVDALNYSKVAPHLRVVNGQVGLADGIVINKCDLVSDEAVGVVRKIVSGVNGRAKIVTAERGKLLSGFVDGLVHAKTDGEAVDERPADVYAVSFRDAGRMDREAFERVTDELGERLLRLKGNIDFGDGAEYVEVVYDQVSREKACGKLGAGTTFTAIGWKVDKDELRGMFEGCVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB0</accession>
    <name>A0A1U9NRB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70274">
        <property type="protein sequence ID" value="AQT70274"/>
        <property type="gene ID" value="STSP2_03480"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03480"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012707962" evidence="1">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35774" checksum="7F4B5D8B72868BF6" modified="2017-06-07" version="1" precursor="true">MKKSVLISCLLFVFCVVGNSYGLAVVDSDYQLERVAGFNYYYPYGHAKEITFDDASNIYVSHDSGGVLKIDQSGNEQFIGSGFENLQGIVWAGGTRYGDNLYAADVYPKAIKQVSTSGQSGVLVNVPNEPLNLTIDHTGNYGGDMFVGTRRSAEIYRIFSDGSVAEFIDMPYLGDRAFVGNMAFDETGNYGGSMFVAIGNYVLDDYKGVLKIDPDGDVTKFLPDKFGWGDFAFDTDGFFNEQMYASNGSDIYSVDTDGTLTMFMEGHDGIRIRDLKFDQDGSLNVLWTNGDHVFNIDKVSLVPEPCSLVLLGVGAFVMGRRRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRL8</accession>
    <name>A0A1U9NRL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70260">
        <property type="protein sequence ID" value="AQT70260"/>
        <property type="gene ID" value="STSP2_03466"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03466"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="626" mass="69840" checksum="75EDD040F59CD8CE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ9</accession>
    <name>A0A1U9NGJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67071">
        <property type="protein sequence ID" value="AQT67071"/>
        <property type="gene ID" value="STSP2_00211"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00211"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15562" checksum="9404639FF2254182" modified="2017-06-07" version="1">MKTAHLVILKRPYLAAILAGSKTVEFRLTKDRRAPFGCVKSGHTLYLKQSSGPVLATATVARVHTEENLTPARIRELKSCYNNEIQGPDTYWAARENANYATLIWLKDIKKIPPRTIQKTDQRPWVVLTEKENFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM7</accession>
    <name>A0A1U9NGM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar rod assembly protein/muramidase FlgJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00055"/>
    <dbReference type="EnsemblBacteria" id="AQT66917">
        <property type="protein sequence ID" value="AQT66917"/>
        <property type="gene ID" value="STSP2_00055"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00055"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rod-binding" evidence="2">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12791" checksum="23E1320CCEC9956F" modified="2017-06-07" version="1">MIDPINSHNLINTAGPEGLNKDASQRLAEEKKKEVAKNFESILVGQLVDQMKDTIGSSGLLEEQGSKQIQDMFFSFLAKDVSKQGGIGLWKQIYQSMNDSEQKSEINVSDSLDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT6</accession>
    <name>A0A1U9NGT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hyi</name>
        <name evidence="3" type="ORF">STSP2_00115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00115"/>
    <dbReference type="EnsemblBacteria" id="AQT66977">
        <property type="protein sequence ID" value="AQT66977"/>
        <property type="gene ID" value="STSP2_00115"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00115"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="65"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34041" checksum="7E79720111653026" modified="2017-06-07" version="1" precursor="true">MDRRTFISTGVAAGAAAVTATSSSVLGAEEKQPAPGKFKLGYAPSLGVFKEHAGTDPIEQIKFMADQGFTAIFDNGLMRKPPELQKKIAAELAKHEMQMGPFVLYADFGTESMVTGKKEDRDMLVNRVKEGVEVAKRTNCKWALMVPGRYNQRTDWGYQTANVVDTMKACAEACEGSEMVIVLEPLNKLNHPGLFLTKMPQAYQICNAVDHPACKIVDDVYHQQITEGDLIRNIDKAYDQIAAFHLGDNPGRREPGTGEINFKNIFKHLYKKGYKGVLCMEHGRSKKGKEGEKALIEAYREADSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX0</accession>
    <name>A0A1U9NGX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcp4</name>
        <name evidence="9" type="ORF">STSP2_00136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00136"/>
    <dbReference type="EnsemblBacteria" id="AQT66998">
        <property type="protein sequence ID" value="AQT66998"/>
        <property type="gene ID" value="STSP2_00136"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00136"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cache_2" evidence="8">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="444" mass="50350" checksum="EEDA9E2C749C670E" modified="2017-06-07" version="1">MTDIKRFIAGMPLHYKLFCAYTMIFASIWLVSTALVYAMAYRTISARVDSELSNTTTALRNLVETCASTAIKNTLKASAQRNREMISSIYAKALKGEISMEQAKAQCTEILLSQKIGSTGYLYCVDSKGIVQVHPFPGVLGRDVSEYNFIKQQIKKKQGYIEYDWRNPGDPAARPKALYMTYFEPWDWIISASSYRSEFLDLVNVDDFRDTVLALNFGKSGYSFVVDVDGNMIIHPKTKGNFSDTDSIKTILREKEGTMRYKWQNPDEHRPREKIVCFMPIPEYGWFVGSSGYVDEMYAPISRIRNVLVITFITGVAAIIALSLWLSSIITKPLSSLTDRVVKACGEEKPECDLEQRNEIRKLTDCFNCFVVKIEDYQSKLKESLAQKEEAMHQLSITNEELEEIVFASSHDLRSPLVSLAGFSHELEVSCGKLQEMISNTHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY2</accession>
    <name>A0A1U9NGY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methanol-cobalamin methyltransferase B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00335"/>
    <dbReference type="EnsemblBacteria" id="AQT67192">
        <property type="protein sequence ID" value="AQT67192"/>
        <property type="gene ID" value="STSP2_00335"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00335"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021079">
        <property type="entry name" value="MeOH-cob_MeTrfase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12176">
        <property type="entry name" value="MtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="49816" checksum="B21FAD62891FCC21" modified="2017-06-07" version="1">MSAKIKITHTDNFIYGTAPNPVTCGHDLSIGTGTVIPEINFTLPGMEVTADNMPAVLAEYAEIIDNVLKRAVHLNVPQLLVEFETLPEMTTNPEWGLKITRLLADKIAECHKTHGIALALRLTINDIREFSRPPILRSGKYLQAMDTFLAGAAEAGADMIAIESTGGKEVNDNALISCDLPAVVFALGILGARDMDFLWNRIVTSCSQNNIIPSGDSACGFANTAMVLAEQKMIPRIFAALVRVISVPRSLVAVTAGAVGPTKDCAYEGPFIKAITGVPISMEGRSAACAHLSTIGNIAQAVCDCWSNESVQNVQLLSAKAPTVSMEQLAYDCRLLTTAARSSHEDARRMRDWLTESDASLDPQAYVLRPDVVIEISKAIAAQPTPYLRTRAAASATLEILRTAHTAGKLHLRDNEIPWLDMLQTQVDSLPEDENELIEQMLNRPDIKNSFHPEEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH60</accession>
    <name>A0A1U9NH60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67107">
        <property type="protein sequence ID" value="AQT67107"/>
        <property type="gene ID" value="STSP2_00248"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00248"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="593" mass="66571" checksum="48FA3CCAB79B0B14" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH87</accession>
    <name>A0A1U9NH87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67165">
        <property type="protein sequence ID" value="AQT67165"/>
        <property type="gene ID" value="STSP2_00308"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00308"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10833" checksum="3698978C26189A7A" modified="2017-06-07" version="1">MGKKEMREKGGDMRRRFTSGRWAKTREMGKRKFVLVYGVFFFGLLSALLSSLIMKLSMPVTVVQIIINLIVFPVCGVFWGAWMWRVNEKRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB4</accession>
    <name>A0A1U9NHB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">apu_3</name>
        <name evidence="6" type="ORF">STSP2_00300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67157">
        <property type="protein sequence ID" value="AQT67157"/>
        <property type="gene ID" value="STSP2_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00300"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="4">
        <location>
            <begin position="784"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="956"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1247" mass="130453" checksum="C05B6746DA17188C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE9</accession>
    <name>A0A1U9NHE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
            <ecNumber evidence="2">3.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nedA_1</name>
        <name evidence="2" type="ORF">STSP2_00340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00340"/>
    <dbReference type="EnsemblBacteria" id="AQT67197">
        <property type="protein sequence ID" value="AQT67197"/>
        <property type="gene ID" value="STSP2_00340"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00340"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052794">
        <property type="term" value="F:exo-alpha-(2-&gt;3)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052795">
        <property type="term" value="F:exo-alpha-(2-&gt;6)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
        <property type="term" value="F:exo-alpha-(2-&gt;8)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="224"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="545" mass="60651" checksum="752E95D11D05782B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK7</accession>
    <name>A0A1U9NHK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00134"/>
    <dbReference type="EnsemblBacteria" id="AQT66996">
        <property type="protein sequence ID" value="AQT66996"/>
        <property type="gene ID" value="STSP2_00134"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00134"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11390" checksum="BDE03E1D76A09C02" modified="2017-06-07" version="1">MNGQEVTVIAELKAKKGKEEDLRQFLLGLIEPSRADQGCIAYFLHESAEEPGLFMFYERWENGEMLESHIQQPHLQALMDKSDELLAEPLDVTSWKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS7</accession>
    <name>A0A1U9NHS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-cone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67355">
        <property type="protein sequence ID" value="AQT67355"/>
        <property type="gene ID" value="STSP2_00499"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00499"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19768" checksum="910300B247E7D35A" modified="2017-06-07" version="1">MHVMVVKADGSLEDYLHTKVLGSLNRAITGAGQADIFAAEQLAEAVTFHVYNCGRNPLTSGQIHSMVISVLVGTGNRKAAELLAEHRTDRQLRRRRIEVIGENGSCGGAIPGTGISSWDKSRIVADLVGQDGLNVRLARAVAGSVEEKVFGLGLSRIRKGLIRQIVLADLEAMIGARDRLEAMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU0</accession>
    <name>A0A1U9NHU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">STSP2_00471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00471"/>
    <dbReference type="EnsemblBacteria" id="AQT67327">
        <property type="protein sequence ID" value="AQT67327"/>
        <property type="gene ID" value="STSP2_00471"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00471"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20925" checksum="E53F2378EF70C660" modified="2017-06-07" version="1">MADIRMIVGLGNPGSKYRGTRHNVGFDVIDMLAQRLAVDVKQKKFGALLGESFYEGKKLILVKPQQFMNRSGQVVATAAGFYKLPLENLIVITDDLALEPGVVRLRPKGSAGGHNGLADIIRKLHSQEFPRLRVGIGQSEVIETVSYVLGKPAPEQKEPLEKAKKDALAATLCWVDEGISNAMNKFNVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX3</accession>
    <name>A0A1U9NHX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase isoenzymes formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ORF">STSP2_00690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00690"/>
    <dbReference type="EnsemblBacteria" id="AQT67542">
        <property type="protein sequence ID" value="AQT67542"/>
        <property type="gene ID" value="STSP2_00690"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00690"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="50"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36041" checksum="B063E38F41CA1543" modified="2017-06-07" version="1">MSIEHTEKILLAHGGGGRLTTSLIENAILPKFQNPELAQLADSADIKLDASEVLFTTDSFVVKPLFFNGGDIGKLAICGTVNDLAVAGAKPVALSLSLIIEEGFEFDTLEKILASASQTARQADVPIVTGDTKVVEKGAADGIFINTAGIGTKYKQTNLSFDRILPGDRIIINGNIGDHGMTIMSQREGIKFKSRLKSDCAPLADLTRTILETGADVKFMRDPTRGGVAATTNEVAQSAGCNIELIETALPIDSSVRAAADMLGFDLLNIANEGKVVVIASEASADKVVNAMQQHPLGKDAAIIGSIADRDDDPIVELLTTIGGRRIVQMPYGRELPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ7</accession>
    <name>A0A1U9NHZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">STSP2_00488</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00488"/>
    <dbReference type="EnsemblBacteria" id="AQT67344">
        <property type="protein sequence ID" value="AQT67344"/>
        <property type="gene ID" value="STSP2_00488"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00488"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="611"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="644"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="949" mass="105159" checksum="97075587B10B9369" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI07</accession>
    <name>A0A1U9NI07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein restricted to Verrucomicrobia-Planctomycetes group</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00707"/>
    <dbReference type="EnsemblBacteria" id="AQT67559">
        <property type="protein sequence ID" value="AQT67559"/>
        <property type="gene ID" value="STSP2_00707"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00707"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026406">
        <property type="entry name" value="Ver/Plancto_CHP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04138">
        <property type="entry name" value="Plancto_Ver_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="16008" checksum="C0C43F4E1EBBCFFD" modified="2017-06-07" version="1">MPVPVFFVNAMKKTIQQIAREDGRYDPKALEFIYEGLGQTVANLKKDQLPETESRHITGQELAWGLGDLAQQRWGRLAKLVLNQWGLHTTRDFGEIVYLMIGHNWMSAQEEDRIEDFDDVFDFERVFEKEFRFEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI57</accession>
    <name>A0A1U9NI57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67196">
        <property type="protein sequence ID" value="AQT67196"/>
        <property type="gene ID" value="STSP2_00339"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00339"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="334" mass="38693" checksum="BCD79BABE2C2041A" modified="2017-06-07" version="1">MRNKNSWLSLLPGFRRKKKKCYLLRELTQFDNADRYAGFELQFFPGHFLVASSELVPFWNVDGAKGSARPEVGEFFVAVLCIHEAKRIILMTTDDVFVVDPRTGQKDLAVPQSKYKYFECVSLPGSKVIINSQLKAKNGSHEHMLLVLNLNTGKIREVPIDFRPMGMFVSDEGCCYLEDQKRTSYVFEDMRVIPCEKIKKWRRQGHAVTCWDDGELIWTISKGSKKFVVGWGDKKLKLKIRKQYIDIARVGGFVWVRHDMKLKQYDRNGDLKNELNLEKKYTSMGEDAEGHLWLFDGDRTVDLFDDDGRLFETVELDLPLKEEVEKECNVSQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI74</accession>
    <name>A0A1U9NI74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">iolG_2</name>
        <name evidence="8" type="ORF">STSP2_00569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67424">
        <property type="protein sequence ID" value="AQT67424"/>
        <property type="gene ID" value="STSP2_00569"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00569"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="203"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="487" mass="55004" checksum="BD3965A40D851188" modified="2017-06-07" version="1">MSSISRRDFVKGSIAATAGLTMAGSAWAQVRGANDDIRIGVAGIRSKGAHHIEHLRGLEGARVVAICDPDTNLLAREKKKFTDDQQTVETYTDVRKMLDSKDIDAIVIATPNHWHSLIGIWACQAGKDVYVEKPVSHNIWEGRQLVKAARKYDRIVQAGTQNRSDIGLIPMMQYIHEGSLGEIEYVHTLTYRRRKSIGKVPGPQPIPDHIDYDLWTGPAELQPLMRERLHYDWHWVWDYGNGSIGNQGIHEVDLAMWALQEDKLAPRVLSVGGRYGYDDDGETPNTMVSILDYESAPVICEVKNLPMNKNRNSMDYYRGIKTGIIIQCKDGYFAGGRGGGWIYDNDGNKIKQFRGDGGGNHQQNFIDAVRSRKRENLAAEIEKGHKSSALCHMAHYSYRMGQKSDPEKAQEAVGENSHAAKVWRRLEEHLFMNWIDLQKEGVVVGPWLEMDSKKETFVEKEDFGPAFWANKLGRGTYREPFVVPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA1</accession>
    <name>A0A1U9NIA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hypF</name>
        <name evidence="12" type="ORF">STSP2_00693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00693"/>
    <dbReference type="EnsemblBacteria" id="AQT67545">
        <property type="protein sequence ID" value="AQT67545"/>
        <property type="gene ID" value="STSP2_00693"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00693"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="209"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="772" mass="84725" checksum="225828A7EDC20406" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID5</accession>
    <name>A0A1U9NID5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67702">
        <property type="protein sequence ID" value="AQT67702"/>
        <property type="gene ID" value="STSP2_00850"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00850"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12774" checksum="24858482DE85B4CC" modified="2017-06-07" version="1">MATERTKEINREVEQLKNDIRKLRSDLTEMLGSVGGYSQEKVMRSRNKLKEAMADLEGRTKERFDHAQKAVREHGDEALNTSRKYIEKKPLASVLISFAVGIVVAGILGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF5</accession>
    <name>A0A1U9NIF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="3" type="ORF">STSP2_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00870"/>
    <dbReference type="EnsemblBacteria" id="AQT67722">
        <property type="protein sequence ID" value="AQT67722"/>
        <property type="gene ID" value="STSP2_00870"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00870"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31830" checksum="7F613EF2071E4AA1" modified="2017-06-07" version="1">MSEQRIGVIGGTGLGDILGEHISDVRFEKVDTPFGAPSGEIMLGSLAGKQIAFINRHGEGHIYGPSDVPFAANIFALKKLGVKSVIASAAVGSLREEIRPGELVLVDQFIDKTFRRRGSFFDGVAAVHAEMAEPCCKMLRDAMLRAAGNLQVRTHAAATYVAMEGPQFSTKAESKMHRAWGGDMIGMTGMPEAKLAREAQMCYSLVALATDYDCWRESVGLTDKHDLLREILGNLEKATENAINLIEAVLKSEEKLIFDDCPCRHSLEMAVMTKQEVIDQAKWEQLGVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG4</accession>
    <name>A0A1U9NIG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX prenyl protease-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00881"/>
    <dbReference type="EnsemblBacteria" id="AQT67732">
        <property type="protein sequence ID" value="AQT67732"/>
        <property type="gene ID" value="STSP2_00881"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00881"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23610" checksum="1424F16BED2E2F17" modified="2017-06-07" version="1">MIAIYAFCALAAVLWFVIFSPWTAEHVSFWPAMVFSTGLLAAAALTAQREKLRELFAWQFRYALIGVVSAVFLYGVFFFGDIVARWMLPFAQRQIEGVYGSRQELPLWLISVFLILVIGPAEEIFWRGFVQQRLGSRWGSFAGWFAATAVYTGVHVFSLNFMLLVASAVCGGFWGLLYWRYKSLWPVIISHALWDVMIFVIWPVGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM2</accession>
    <name>A0A1U9NIM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67440">
        <property type="protein sequence ID" value="AQT67440"/>
        <property type="gene ID" value="STSP2_00587"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00587"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3711" checksum="E47464AF8A7992A0" modified="2017-06-07" version="1">MLYSPRNVLVAVTAQKFTHVNFKEYLTWKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM9</accession>
    <name>A0A1U9NIM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67792">
        <property type="protein sequence ID" value="AQT67792"/>
        <property type="gene ID" value="STSP2_00941"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00941"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="32545" checksum="EF99B6C4651E37DA" modified="2017-06-07" version="1">MAKTHRKYWFRMAARSAYLLIRPSNTAALVDKSYDRISPTYDRAWTDHMRNLTEHLIDRLNPQPGNTCIDLTCGTGFATSLLAAKTDTTVTGVDRSQGMLDQARQNHAHNCKFVQADILEFLKNRPTASADIITCCWGLGYSRPFAVLRQIKRVLKPHGKVAIIDNSLFSLREIIFCSFLTFAENPRALQNVMHFKFLPGPRTLRTMFAMLNLKTLHSDQGSRSYTVDTGRDAIARLKSTGAAAGFEYASGRTDDTAIFDRFAQIIEDKYMTPDGIKVTHRYLAGIAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ7</accession>
    <name>A0A1U9NIQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67801">
        <property type="protein sequence ID" value="AQT67801"/>
        <property type="gene ID" value="STSP2_00951"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00951"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="95" mass="11050" checksum="A0116483E428D360" modified="2017-06-07" version="1">MNWYRKKDEHMTLLFEVLRKRGEDDLLVKFGAGRLSEGDIKHAVDIVLGEFCETGLREDDEPNRRGERLDDLMGFLVGELEELEVCASEGREYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT8</accession>
    <name>A0A1U9NIT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00806"/>
    <dbReference type="EnsemblBacteria" id="AQT67658">
        <property type="protein sequence ID" value="AQT67658"/>
        <property type="gene ID" value="STSP2_00806"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00806"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025529">
        <property type="entry name" value="DUF4416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14385">
        <property type="entry name" value="DUF4416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20977" checksum="AA8C1CD3E5D02E84" modified="2017-06-07" version="1">MWEVGRPEPVKLIVGILGADEECLRFARERVEDEFGELDFVSEVWAFDQTRYYEDELGERPLRQFVSVGELVDPGRLAGIKHAANDMERELADEVGGELGRPVNLDPGYLEPAKLVLASTKNFAHRIYIGEGMYAEITLGYRRGEWLGFEYSFPDYKGGRYHAFLSKVRARLVEQLREMRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX5</accession>
    <name>A0A1U9NIX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I secretion outer membrane protein, TolC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67883">
        <property type="protein sequence ID" value="AQT67883"/>
        <property type="gene ID" value="STSP2_01035"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01035"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="543" mass="61065" checksum="43EC5E9F80B47F30" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY7</accession>
    <name>A0A1U9NIY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative electron transport protein YccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yccM_2</name>
        <name evidence="7" type="ORF">STSP2_00934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00934"/>
    <dbReference type="EnsemblBacteria" id="AQT67785">
        <property type="protein sequence ID" value="AQT67785"/>
        <property type="gene ID" value="STSP2_00934"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00934"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="399" mass="44438" checksum="C32B8033A69EF30D" modified="2017-06-07" version="1" precursor="true">MKKLTLVLTIIFAVLATSALSTRLWSGPAEKHTESSPQQPKQLTYSPDMTLKQFAAANDIPRPALKKVFSLSSPNDLTKTLASFELTQPQLKQKLSQIRALKKEHATKDWRKIVIKFALWFAWLAVAFTLLRKAKLTRRNRTALLAVPVVLFGIVLGADPNPMRTVKDAIALFATENIIFPPRLLAFAVFTLLVIFANKLICSWGCQLGTLQDLLFRTMHEKGTPPRLLKPRKIPFAVTNTVRILFLAAFTAVVFITGYDFIEHIDPFKVFKPQALNLAGGIFLAGILLASLVIYRPWCHLFCPFGLTGWIAEKLSIFKIKINRHTCIDCKACARACPSPVMDHILHSKKPTPDCFSCGNCIEACPTNSVSFTAANPNKTTNPADITETQEQTRHPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ6</accession>
    <name>A0A1U9NIZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">prfB_1</name>
        <name evidence="4" type="synonym">prfB</name>
        <name evidence="7" type="ORF">STSP2_00906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00906"/>
    <dbReference type="EnsemblBacteria" id="AQT67757">
        <property type="protein sequence ID" value="AQT67757"/>
        <property type="gene ID" value="STSP2_00906"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00906"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="334" mass="37797" checksum="F9BB7B7ED937EBDF" modified="2017-06-07" version="1">MANPSFWDDPEQAQKIVTSLSAVKSMVEPAQEVTNSVQDLQELLILAEDEGDEDVLQSVAEDAEKLQKRCDRIEVAAMLSGPDDMRNCFFSIHAGAGGTESCDWASMLLRMYTRYFEQNDFKFEELDTTPGEEAGVRSITLKVAGPFAFGKLVCEAGVHRLVRISPFDSQSRRHTSFAAVDVMPEYEDDIDIDLKDDDLRIDFYRASGAGGQHVNKTSSAVRITHLPTGIVVQCQNDRSQHKNKAEAFKMLKSRLYMLEQQKRDDELAKLYGNKGEIAWGNQIRSYVMQPYQMVKDHRTDEQTGNVDAVLDGDIEKFIESYLKYKSNKKNKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ96</accession>
    <name>A0A1U9NJ96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67818">
        <property type="protein sequence ID" value="AQT67818"/>
        <property type="gene ID" value="STSP2_00968"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00968"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="311" mass="34981" checksum="96F67BA8E10E0EDF" modified="2017-06-07" version="1">MELFVGIDVSKYFFDVCCGVDGKVSHFDYNQQAVAECVKMLERVEPTLVVLESTGGYELQLALAVQDSGLPVVIVNPSRVRSFGRACGKIAKTDKIDARTIAWYASALRPQVRGRINRKMCKLKALTARRRQLVDMRTAERNRLDHVFEKAIRRSVEAVVKTIEREIGKVESAMAEHIDDDPQLREKVIKMRTVPAIGEVTASMIVSELPEIGSLNRRQIASLVGVAPMNRDSGLMRGKRTTGGGRKEVRTRLFMPTLVAIQHNPVIRKFYRRLLKNGKAKMTAVVACMRKLLTIINFMLAKNEEWKPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB2</accession>
    <name>A0A1U9NJB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core-O-antigen ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00808"/>
    <dbReference type="EnsemblBacteria" id="AQT67660">
        <property type="protein sequence ID" value="AQT67660"/>
        <property type="gene ID" value="STSP2_00808"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00808"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="760" mass="82760" checksum="FB8FE169E9F99ECF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC5</accession>
    <name>A0A1U9NJC5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable pectate lyase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00985"/>
    <dbReference type="EnsemblBacteria" id="AQT67834">
        <property type="protein sequence ID" value="AQT67834"/>
        <property type="gene ID" value="STSP2_00985"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00985"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640375" description="Probable pectate lyase C" evidence="5">
        <location>
            <begin position="20"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="6">
        <location>
            <begin position="147"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="7">
        <location>
            <begin position="408"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="6">
        <location>
            <begin position="521"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="936" mass="97921" checksum="8B5C9A91F47782B9" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE0</accession>
    <name>A0A1U9NJE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ORF">STSP2_00838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00838"/>
    <dbReference type="EnsemblBacteria" id="AQT67690">
        <property type="protein sequence ID" value="AQT67690"/>
        <property type="gene ID" value="STSP2_00838"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00838"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="42373" checksum="F7279E950C1209DC" modified="2017-06-07" version="1">MIYHFLHTFREFFTGTLGFYAYEEVMFRAILAAITSATIALITGPKIIRWLMKKKIGDHPEFNHTDLNDLMKERANTPTMGGLIILLAMMVSTFLWAKLDNPFIHKAIFIVIWFGAIGAVDDWLKLTSKIKNRSRDGLKAWEKLVFQFGGAVLIAHFLYADFANVPDARMLWLPFYKHGIPLAGWAFAIIAVLYISATSNAVNLTDGMDGLAPGCIGIVSATLIILCYVSSESMSPHGESQTWASYLLLPHIPQAGELCIFYASIMGAILGFLWYNSHPAQVFMGDIGSLPLGAAMGYGAVVARHEILLLLIGGVFVMEMLSVIMQVGYYKYSGGKRIFRCAPIHHHFHLKGWSEPQVVSRFWLLAIFFATIALATLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF3</accession>
    <name>A0A1U9NJF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator AraC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68063">
        <property type="protein sequence ID" value="AQT68063"/>
        <property type="gene ID" value="STSP2_01218"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01218"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="89"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="21612" checksum="08137720DD089955" modified="2017-06-07" version="1">MFTPFRRISLTTEIHIGHNDRCKDRARSDHSRPDIFNTEQAKQLTSEALTDVLTKNSIAISMDGVGRAFDVRTAGIQSACSRPMYMQHEQLLNPINGTQRELIPGSQIPHVLNATCLSRRELEKRFKAALNKTIKDEIERLRIELIQKKLRNSTQSISQIAAELESTDREHFARYYKNQTGQSPMQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG8</accession>
    <name>A0A1U9NJG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67947">
        <property type="protein sequence ID" value="AQT67947"/>
        <property type="gene ID" value="STSP2_01099"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01099"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15742" checksum="00D26E00F94C1E55" modified="2017-06-07" version="1">MKLKYLFFNDKAVIKSVDKTTRRVLSRFGAYVRRSARSSIRKRKKSAPPGKPPSSHSGLLKRFIFFGYEPKNRSVVIGPVDLQSKQGETPSVLEYGGRTTVKNKDKKKQIEVKARPFMGPAYEKEQPKLPGMWQDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH3</accession>
    <name>A0A1U9NJH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">infB</name>
        <name evidence="11" type="ORF">STSP2_00814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00814"/>
    <dbReference type="EnsemblBacteria" id="AQT67666">
        <property type="protein sequence ID" value="AQT67666"/>
        <property type="gene ID" value="STSP2_00814"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00814"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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        <location>
            <begin position="396"/>
            <end position="564"/>
        </location>
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        </location>
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        <location>
            <begin position="399"/>
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        </location>
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            <begin position="118"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="897" mass="97991" checksum="B208DECCC14F7DDE" modified="2017-06-07" version="1"> </sequence>
</entry>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="4">ST-NAGAB-D1</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68109.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1225" mass="137620" checksum="FF50B39E633B119E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="AQT67954.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27786" checksum="4F2CC3D9931D9086" modified="2017-06-07" version="1">MSITVAEKFDSPQITKGQNPSATCSFIVQGTDDESEALSALLAQTPDVYQDMPRNSHGIDHLAQNLWEGAVHYGSGASDVNSFATSFDTTGGTQHITQSLSTISAYAKSGSTAPLYGGAIGVTKSDVTGVDITVPVFNFSERHFILDANANALTYRNLTGCVNNLPFRGFAVGEVLFLGATGSIGQDGLWEVNFKFAASQNKSNITVGSITGIVKGGWDYMWVRYEDTEDMSAGAIVKRPTAVYVERVYPLADFSLLGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ1</accession>
    <name>A0A1U9NJQ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">thyX</name>
        <name evidence="2" type="ORF">STSP2_01307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01307"/>
    <dbReference type="EnsemblBacteria" id="AQT68152">
        <property type="protein sequence ID" value="AQT68152"/>
        <property type="gene ID" value="STSP2_01307"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01307"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27280" checksum="32161BDB63B30E49" modified="2017-06-07" version="1">MGQVHARVRLVRMTEDAEGVVASAGRLCYASETEDILKQDKGSAGEFIQRIIKMGHVSILEHAVFTFFVEGVSRALTHQLVRHRIASYSQRSQRYVAHNEFDYIVPPELEGKTVEVDGEQVDAVAYFEETMGEIAGRYAKLQGALGGNSEKSNQDARYVLPNACETKIFVTMNARELLHFFEERLCMRAQWEIRGAAEQMLELAKGACPSIFAGVGPKCVRMGRCPEGKMTCGKYQEMKEKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ1</accession>
    <name>A0A1U9NJZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68127">
        <property type="protein sequence ID" value="AQT68127"/>
        <property type="gene ID" value="STSP2_01282"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01282"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9300" checksum="3B4086C7CEEB173C" modified="2017-06-07" version="1">MKKAKNVTVVVSCVVTFVLTWLVVAGGVSMLGYVWKDVPEVNLVVTIGAPAVGLFVALLAARQSYRAAMKGKAWRLYEEQDGEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ5</accession>
    <name>A0A1U9NJZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH-type transcriptional regulator YddM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yddM</name>
        <name evidence="3" type="ORF">STSP2_01385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01385"/>
    <dbReference type="EnsemblBacteria" id="AQT68229">
        <property type="protein sequence ID" value="AQT68229"/>
        <property type="gene ID" value="STSP2_01385"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01385"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="370" mass="42806" checksum="762B82ECC0FC281F" modified="2017-06-07" version="1">MAVKYKPFINIGPGFYIEEELETRGWTKQDLATILGLSSTHVSELIHGKRAVSLETAKLLSKAFGQSPQYWLNLYTNYKLREEKTSKAENETEIKANILSHMPIADMVKKGWLPKWNGKLSRLVENVEQFWGRQGLDFAFMDKCAAPAFRKSDAFEKYNRYYALTWHHMARKCAAQYKVEKYDSKKLTAIANELAEYSYAENGIECLIQDLAYAGVKFFILPHLEKTYTDGSAFWDGDNPVIVWTGRFKREDNFWFTVAHEIAHILFHLRSKKAVFIDSENMDITEQEDEANLFAQKAYKYDEIVSFLGGHKITVFMVRKCSEELKISPSLIVGQLRHHQILKHYQLRNLVNSDVLESIPDEFFADVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK65</accession>
    <name>A0A1U9NK65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">leuS</name>
        <name evidence="14" type="ORF">STSP2_01457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01457"/>
    <dbReference type="EnsemblBacteria" id="AQT68299">
        <property type="protein sequence ID" value="AQT68299"/>
        <property type="gene ID" value="STSP2_01457"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01457"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="258"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="452"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="696"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="615"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="844" mass="96430" checksum="9E0B5A7550467C7B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA7</accession>
    <name>A0A1U9NKA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ComEA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">STSP2_01333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01333"/>
    <dbReference type="EnsemblBacteria" id="AQT68178">
        <property type="protein sequence ID" value="AQT68178"/>
        <property type="gene ID" value="STSP2_01333"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01333"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="400" mass="44804" checksum="AB566AB217566DFC" modified="2017-06-07" version="1">MRFSDMKNRRAVILIGVLWAIALVTTIVVVVARSSMLDSRISLTSAENIRGHWACRAGLEKAIAVLAYDETSVDSFADLWYDNVEDFNDVPLDLCSFNVAVVDESSKLSLNSATKEQLIELPYMTDEIADSIIDWRDRDENVTGEGAETGYYLNLENGYEPPNGPFTTFDELLRVCGVTESLVYETARWDDMLTCWSQSGSSSDDTTEKIDVNRVGERQLRNRLSLAQAHARWIVENRDFDSIGNLLANNSPDEPQRNADRSEQPMPLDRQTFFSIIDQVTVSSNNNQQQGQAKVNINTAPRDVLVAVFEGDETLAEEVLSYREGAVEGFASLGDLAEIKSLTNRKIREFIDYLTVNSSVFRVTSEAVLDATGTTRSLTAIVDRSQTPVRILYYYEGPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF2</accession>
    <name>A0A1U9NKF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM</name>
        <name evidence="3" type="ORF">STSP2_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01539"/>
    <dbReference type="EnsemblBacteria" id="AQT68379">
        <property type="protein sequence ID" value="AQT68379"/>
        <property type="gene ID" value="STSP2_01539"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01539"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="55519" checksum="C0C02AE853CE90B4" modified="2017-06-07" version="1">MLARLYSVTLEGIEGIICEVEVDVSRSGFEKPMIVGLPDAAVKESSERVHSAIVNSGYQYPDTQSLVNLAPADIKKAGPAFDLPIALGMLCCAGALESEMFKEHVIIGELALDGRVRPVNGVLSMAMSAAKHGFKSIIVPEENAYEAAVVRDIEVYAVGSLAQAAAFLKGDLPLEPTNVNVEDIFGRRSKYAVDFSDVKGQETVKRALTIAAAGGHNVMMIGPPGAGKTMLAQRIATILPPLNLSESLETTRIYSSVGLLERGSALMPTRPVRTPHHTASGPALIGGGTNPRPGELSLSHHGILFLDEFAEFPRNVLEMIRQPLEDGTVTVARAKGTITFPAQFMLIAAMNPCPCGYFGTNTRQCKCTPNQIDRYMSKVSGPLLDRIDIHTDVPAVEFRKLRDTSAQESSKSIRDRVVNARHRQAARFGDSNLTTNATMSHKQVEKFCRLDDNSEHLLKQAMLEFDLSARAHDKICRVARTIADLQDHENIQPEHLAEAISYRKLDRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH2</accession>
    <name>A0A1U9NKH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_01245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01245"/>
    <dbReference type="EnsemblBacteria" id="AQT68090">
        <property type="protein sequence ID" value="AQT68090"/>
        <property type="gene ID" value="STSP2_01245"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01245"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010706342" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="187"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="373"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="493"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="818"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="932" mass="105918" checksum="181E62DBFD22B6F9" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR8</accession>
    <name>A0A1U9NKR8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">STSP2_01557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01557"/>
    <dbReference type="EnsemblBacteria" id="AQT68397">
        <property type="protein sequence ID" value="AQT68397"/>
        <property type="gene ID" value="STSP2_01557"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01557"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24859" checksum="8CCC3AFC3B78EC93" modified="2017-06-07" version="1">MLNDSLKSELIVRDCGTSGYREMLDLQLELLERRIADEVPNTVLIVEHEPVVTMGARKSENRLLLGDEEFGRRGIVLEAVRRGGGTTAHNPGQIVLYPVVKLKSLGLSVSDYVRSLEQIGIDMLAEFGLECGRKKGAPGLWVGERKIGSVGVKVQKWVTYHGMAININNDLGIFDTIVPCGLAGVEMTSLVKEVGGEIDMKRVRKVLAGVCVEHWSDKELVRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT3</accession>
    <name>A0A1U9NKT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68200">
        <property type="protein sequence ID" value="AQT68200"/>
        <property type="gene ID" value="STSP2_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01355"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15226" checksum="AC6633F98E980994" modified="2017-06-07" version="1">MGVASLCPAESPEDNAPTGALRITGKFVRSITLESVGTEEVNTDGTLEVPTGSHQIRKITLENGWTAYPYQLVDIKAGQTTDVKLGGPLKQKITANRQGGYLNLDHSVEGVCGKQYRNGDNPPAFTIYKGDTKVHSGKFAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY1</accession>
    <name>A0A1U9NKY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01639"/>
    <dbReference type="EnsemblBacteria" id="AQT68475">
        <property type="protein sequence ID" value="AQT68475"/>
        <property type="gene ID" value="STSP2_01639"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01639"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="22554" checksum="9328E5EB10F2599B" modified="2017-06-07" version="1">MEDYKAKNVNKDLASSAEAHSDPAYASRFFRLFMQNQKKLFKYILMLVPCRSDAEDILQDTATLMWTKFDEFKPGTNFAAWGIKIAHFKVLRYYRSRKRLHVPITDDILEIVTEQAVQAVDEKDHKIKVLQQCMKELPEKDRALIELRYDRGLAPKKVAQKVSRPVRGIYKSLSRIHNSLLVCVRRRLNQEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL00</accession>
    <name>A0A1U9NL00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68613">
        <property type="protein sequence ID" value="AQT68613"/>
        <property type="gene ID" value="STSP2_01781"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01781"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="33" mass="3711" checksum="9C416158BA04595F" modified="2017-06-07" version="1">MIFVTVTLRVSNDIIHVLTMVKLLDKQGVKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL08</accession>
    <name>A0A1U9NL08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01670"/>
    <dbReference type="EnsemblBacteria" id="AQT68505">
        <property type="protein sequence ID" value="AQT68505"/>
        <property type="gene ID" value="STSP2_01670"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01670"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24219" checksum="8F3CF7BFBDF2AB00" modified="2017-06-07" version="1">MDARLRLLGRTFLRGLVAILPIAVTIVILVWLGDKAEAILGAFIKFLIPNEWYIPGMGVIAGILVVLAVGALLKMWIVRRAFAYSETLMVRVPLVRLVYGSVRDLTSFFDKSKKREFNKAVLVTLSEGEVQTIGFVTREDFTGMPEEISAGDKVTVYIPWSYQVGGFHLLVPKSRVQPIDLSVDRAMRFAVTAGVSMSEENHEDRFEKIASSEPGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL10</accession>
    <name>A0A1U9NL10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01651"/>
    <dbReference type="EnsemblBacteria" id="AQT68487">
        <property type="protein sequence ID" value="AQT68487"/>
        <property type="gene ID" value="STSP2_01651"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01651"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15253" checksum="5C39F0AA1276ECE8" modified="2017-06-07" version="1">MVKTEKIKIATKGNCDIVNISEEVANAVADSGIKNGIVCVFNVGSTAGVTTIEYEPGLVNYDIEAAFERIAPENIRYEHEETWHDDNGHSHVRASLLGPSLTVPFTSGQMTLGTWQQLVLIDFDTRARTRTVVCQIMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL86</accession>
    <name>A0A1U9NL86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2075 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01659"/>
    <dbReference type="EnsemblBacteria" id="AQT68494">
        <property type="protein sequence ID" value="AQT68494"/>
        <property type="gene ID" value="STSP2_01659"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01659"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2075" evidence="1">
        <location>
            <begin position="245"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="661" mass="75473" checksum="1E7BF13C93054522" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG0</accession>
    <name>A0A1U9NLG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ahcY_1</name>
        <name evidence="4" type="synonym">ahcY</name>
        <name evidence="9" type="ORF">STSP2_01746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01746"/>
    <dbReference type="EnsemblBacteria" id="AQT68578">
        <property type="protein sequence ID" value="AQT68578"/>
        <property type="gene ID" value="STSP2_01746"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01746"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="234"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="474" mass="52178" checksum="038C273B3C785228" modified="2017-06-07" version="1">MAVIELDKNLDHKIADISLAQWGRTEMELAENEMPGLMATRAKYGKQKPLKGLKVMGSLHMTIQTAMLIETLVELGADVRWASCNIFSTQDHAAAAIVEKGSAAVFAWKGETLEEYWWCTEQALTWPDGSGPDLIVDDGGDATLFVVQGMRAEKDPSLLEQKYDNPELQIVMDRIKAGRQTDPQKWTNIAANIKGVSEETTTGVHRLYQMQNTGDLPFPAVNVNDSVTKSKFDNLYGCRESLADGIKRATDVMVSGKIVVVAGYGDVGKGCAQSMRGLGARVLITEIDPICVLQATMEGYEVTTMDKAASIGDIFVTATGCCDVITGEHMEQMKNEAIVCNIGHFDSEIQTIYLHENPGCHQQTIKPQVDKWTLNSGRSIILLAEGRLVNLGCATGHPSFVMSNSFTNQCLAQIMLAEEDLENKVYTLPKKLDEEVARLHLERLGAKVTKLTPKQAEYLGISAEGPFKPEHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG2</accession>
    <name>A0A1U9NLG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01955"/>
    <dbReference type="EnsemblBacteria" id="AQT68782">
        <property type="protein sequence ID" value="AQT68782"/>
        <property type="gene ID" value="STSP2_01955"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01955"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9812" checksum="C938F2263AB50F1F" modified="2017-06-07" version="1">MKNDVLTLASESSHPKPPLLTSEQCARMCGISRRTWHRLSASAKVPSPVKIGGNVRWRSSDMELFLEWNCPSREEFEQRKEALNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH5</accession>
    <name>A0A1U9NLH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01965"/>
    <dbReference type="EnsemblBacteria" id="AQT68792">
        <property type="protein sequence ID" value="AQT68792"/>
        <property type="gene ID" value="STSP2_01965"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01965"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013318915" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="572"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111437" checksum="A07847FC42CBCE8A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ1</accession>
    <name>A0A1U9NLJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68779">
        <property type="protein sequence ID" value="AQT68779"/>
        <property type="gene ID" value="STSP2_01952"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01952"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10663" checksum="02943556AB910EFC" modified="2017-06-07" version="1">MNNEKRKLHVERERSNSPASYPELMTEPELIQYLRIPEISDASDYHNVIEHLKRMRDLPRIRICNRVLYYLPAVRDWLEGQMGFMDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME5</accession>
    <name>A0A1U9NME5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69122">
        <property type="protein sequence ID" value="AQT69122"/>
        <property type="gene ID" value="STSP2_02309"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02309"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011453">
        <property type="entry name" value="DUF1559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07596">
        <property type="entry name" value="SBP_bac_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="29599" checksum="2A4E933F30EF95CD" modified="2017-06-07" version="1">MLDQKRKAFTLIELLVVIAIIALLMSIMMPALSKVKGMARRVVCGNNVKQINLGTHLYASQNNDKLPLNESGFWYWDISYYTTDFLMDEGGMVKETFYCPADRVKSKEQNMEKFWRYSEAVMNDGKVPEREEETDTTWRRQNYRVMSYFYIAPRADGSVRGFDPVDVDLHRKLSAIKNASSFTLFSDAVLQDRNTEKFTDIVGGSAAFGLMDNTSHIKNNGQPQGGNAGFADGHVEWVKYDDMIERNPDKRNMPAHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME7</accession>
    <name>A0A1U9NME7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_4</name>
        <name evidence="8" type="ORF">STSP2_02269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AQT69083"/>
        <property type="gene ID" value="STSP2_02269"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02269"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
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        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
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        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
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            <end position="66"/>
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            <end position="100"/>
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            <end position="140"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="209"/>
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            <end position="256"/>
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            <end position="297"/>
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            <end position="389"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="445"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="493" mass="53575" checksum="6127C9BC03EA1377" modified="2017-06-07" version="1">MSNFTLIDGGIVGVYILAVVTIGVMVKRYVSKVDQFLVAGRELNIYLGIASLTACEFGIVTCMYTAQNGYDKGFAGATPGILLALAMFIVGATGFGIKPLRKAGVMTIPELFEKKFGPKIRWMSGVVIVLGGLLNMGIFLRMGGDFLVAVCGLNPEYLEITMTLLLLGIGLYTIMGGMISVLITDYLQFIMMSIGLLIVTVLIFIKVGWGSMVEAIQMNYGEGGFNPFVHEQMGVMYVIFNALVALSVVLTWQVMIQRVLSTKDIATGGKIYKGTSPFFVCRFILPGLWGVAALAVLTPEQVGDNTMLAMPKFLGGFVPPIAMGITVAAMLAADMSTDASYMLTWGSVIYNDIMAPFHKGKWSQKKGLMWNRFIIAMIGVFLLVYGLWYKIEGDVWTYLGVTGSIYLSSMSVLLIACCYWKKANSWGAAAAIIVGSVMPFSFLVMQKVPATEELTVRVGPYIWGTATYVLVAIAMVTGSLLKFKVNPGRDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG4</accession>
    <name>A0A1U9NMG4_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">STSP2_00354</name>
        <name evidence="2" type="ORF">STSP2_00840</name>
        <name evidence="3" type="ORF">STSP2_01178</name>
        <name evidence="4" type="ORF">STSP2_01248</name>
        <name evidence="5" type="ORF">STSP2_02019</name>
        <name evidence="6" type="ORF">STSP2_02286</name>
        <name evidence="7" type="ORF">STSP2_02980</name>
        <name evidence="8" type="ORF">STSP2_03256</name>
        <name evidence="9" type="ORF">STSP2_03268</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67211">
        <property type="protein sequence ID" value="AQT67211"/>
        <property type="gene ID" value="STSP2_00354"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67692">
        <property type="protein sequence ID" value="AQT67692"/>
        <property type="gene ID" value="STSP2_00840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68024">
        <property type="protein sequence ID" value="AQT68024"/>
        <property type="gene ID" value="STSP2_01178"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68093">
        <property type="protein sequence ID" value="AQT68093"/>
        <property type="gene ID" value="STSP2_01248"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68843">
        <property type="protein sequence ID" value="AQT68843"/>
        <property type="gene ID" value="STSP2_02019"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69099">
        <property type="protein sequence ID" value="AQT69099"/>
        <property type="gene ID" value="STSP2_02286"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69783">
        <property type="protein sequence ID" value="AQT69783"/>
        <property type="gene ID" value="STSP2_02980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70054">
        <property type="protein sequence ID" value="AQT70054"/>
        <property type="gene ID" value="STSP2_03256"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70066">
        <property type="protein sequence ID" value="AQT70066"/>
        <property type="gene ID" value="STSP2_03268"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00354"/>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="19055" checksum="766E53A4472FDE26" modified="2017-06-07" version="1">MCLYARDLSTSEGQQIQRILRSSKSRIKIRRGQVILASNQGYKVPAIAELVHYSPHHVRAIIKDFNQRGLKALEPKPRPGRPPEFTEDDKAIIAETAKCPPDLLDCPFKRWSLEKLREYLVQEKIVPTISIETLRTILREKKVKLRRTKTWKECNDPNLKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK5</accession>
    <name>A0A1U9NMK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylE_4</name>
        <name evidence="8" type="ORF">STSP2_02326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02326"/>
    <dbReference type="EnsemblBacteria" id="AQT69139">
        <property type="protein sequence ID" value="AQT69139"/>
        <property type="gene ID" value="STSP2_02326"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02326"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="491" mass="54110" checksum="19B0D8C86DE7A8FC" modified="2017-06-07" version="1">MVDESQAKTKLYLVFITLVAAIGGLLFGYDTAVISGTVSSLNENFIEPLDLSELQANSRTGMIVSSALIGCIIGGLTGGFVSDRLGRKKGLILASILFLLSAIGSAWPEVFFARFGTGGAEYTLHFVIYRIIGGIGVGLASMLTPMYIAEVAPAKIRGTLVSWNQFAIIFGMLVVYFVNYMIARSGDDQWLDAIGWRWMFASEAIPAVLFFSLLLFIPESPRWLVLKGQQSRAAATIDRIVPGRSDSEIKEIKESISHNKSAKIFSYGFMIVFIGVALSAFQQFVGINVVLYYAPEIFKNMQLSTDAALLQTIIVGAVNLTFTIVAILTVDKFGRKILQIIGALVMAFGMLCLGMTFFFQSMGILSLICMLIYIAGFAMSWGPVTWVLLSELFPNQIRGKVMALAVATVWISNYLVSWTFPMMDKNSFLVDKFHHGFAFWVYAAMAILAAVFVAKFVPETKGLSLEEMESLWYQAKKEDKLVPDRHAKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK7</accession>
    <name>A0A1U9NMK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69151">
        <property type="protein sequence ID" value="AQT69151"/>
        <property type="gene ID" value="STSP2_02338"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02338"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="21566" checksum="390205209A41516B" modified="2017-06-07" version="1">MVDFLTYIIIADNGPPDFSWVIPVIVFLLYIIGGIAKFFQQQKKSSPAKPAKQPRSPRDVKSPREETKGRTLQTESRASRKARRDEDRHVTPHRADEESPWQRLARQKREEARELARTGLKSEEIQQTPEIKSMEQAMQESEQQGMEVPSLTRDIAKGLQDPQSLRKAVIFSEILKPPVSMRDDSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT4</accession>
    <name>A0A1U9NMT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69223">
        <property type="protein sequence ID" value="AQT69223"/>
        <property type="gene ID" value="STSP2_02412"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02412"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010768">
        <property type="entry name" value="GATase1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07090">
        <property type="entry name" value="GATase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase1_like" evidence="1">
        <location>
            <begin position="63"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="28627" checksum="298A9757048D21EE" modified="2017-06-07" version="1">MDIFERMNTKILYLGDTTLDTAASYLAGVMKHFKIDFDYRPSDQAFIDDLLAKDYAVMIISDYPGSNFTAEQLEAVAEKVKAGMGLLMLGGWESFTGANHEYTDTPLKDVLPVVMQPSDDRINSSGPCLIEKSVDHEIVAGLPFEKHTPGIGGFNRFQSKPGANTILWSRQFRAFLKEGDDFEFEPFAEAEPLLVVSNYGKGRTCAFATDAAPHWVGGLVDWGDARVESQAEGAEAIEVGNWYAQFFANMVKWTARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN54</accession>
    <name>A0A1U9NN54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fucU</name>
        <name evidence="4" type="ORF">STSP2_02454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02454"/>
    <dbReference type="EnsemblBacteria" id="AQT69265">
        <property type="protein sequence ID" value="AQT69265"/>
        <property type="gene ID" value="STSP2_02454"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02454"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15782" checksum="817161368D5EFEA1" modified="2017-06-07" version="1">MLKNIPSILSPELLKVLMEMGHGDEIVLADGNFPSASLAQRLIRADGHNVPDLLEAILSVFPLDEYVDKPVSLMQVVPGDNTKPTIWQEYDKIVQASGEPFGEFEFVDRFDFYERAKGAYAVVATSEGALYANVILKKGVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN67</accession>
    <name>A0A1U9NN67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69343">
        <property type="protein sequence ID" value="AQT69343"/>
        <property type="gene ID" value="STSP2_02532"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02532"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="38078" checksum="BAF7EA8498EC7EA2" modified="2017-06-07" version="1">MTSLQENIFNSRRRRDEKKFKLWKYAGLMLTYKCSAACAFCYYNCSPDKGGLMKTETAVGAWESLERLAGARASVHITGGEPFLYADRLAEVLNEAKRMGLRPADSVETNASWAVSSSVIERNVRLLKDAGVERLKISWDPFHAEYISTDKIKRLASAAEDILGRERVLVRWADYLDAELDFAGMTEEEKQAVYKSAMGDYPCRLTGRAAGRLGHLAERKPLEIIQKQNCRRTWMDGKGVHIDPYGNIFSGLCSGIIVGNVEDRSLEDIWRSLDIENEQMVARLVEAGPAGLLNTALEAGYEVRGEYAGKCHLCTDIRQFFFDNGRFQGIIGPLECYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB7</accession>
    <name>A0A1U9NNB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin biosynthesis protein BioC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02632"/>
    <dbReference type="EnsemblBacteria" id="AQT69442">
        <property type="protein sequence ID" value="AQT69442"/>
        <property type="gene ID" value="STSP2_02632"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02632"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_14" evidence="1">
        <location>
            <begin position="302"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="423" mass="48383" checksum="3C0113E2386D1FD2" modified="2017-06-07" version="1">MKTISLRSSKQYVSPQKLEEDTGIKLRTYNCPSCESQDVHCFYHVPELPVHSVLLLKSVEAAKNCMRGDVALGMCLHCGFVANLAFDESLIHYGTDCEESQAFSSVFNVFHKRLADYLINKYNLKNKRIIEIGCGKGEFLTLLCKQGGNQGLGFDPAYVPGRNEEESTVDVDFVQDFYSSDYADENADFICCKMTLEHINDTGNFIQQLRDNIGNQHDTTVFFQVPNITRIFNEIAFWDVYYEHCSYFSDSSLCNLFEMCGFKILRSWSDYGSQYLMIEARPAENNTWPEDCVKPEMLGLTRHFSSSVMHVRDRWKKYLNRNHEQRKRTILWGSGSKAVSFLNSLRIGKEIEYIVDINAFRQNTYSAGTAQKIVRPQFLKEYKPDEVVIMNPIYRDEIGGSLAKMGLTPKISTVLLPDVMGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG6</accession>
    <name>A0A1U9NNG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gspE_2</name>
        <name evidence="4" type="ORF">STSP2_02526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02526"/>
    <dbReference type="EnsemblBacteria" id="AQT69337">
        <property type="protein sequence ID" value="AQT69337"/>
        <property type="gene ID" value="STSP2_02526"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02526"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="159"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="550" mass="62253" checksum="D9D394CCDA1259F8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL4</accession>
    <name>A0A1U9NNL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycobacterial persistence regulator A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mprA</name>
        <name evidence="3" type="ORF">STSP2_02734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69542">
        <property type="protein sequence ID" value="AQT69542"/>
        <property type="gene ID" value="STSP2_02734"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02734"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15773" checksum="D5F7984256923F6A" modified="2017-06-07" version="1">MFEFLFGNKKAKKTKILIVDDEPNIVQTLKDRLEMNEYAVLTAENGKEGLDTATAEKPDIILLDVIMPIMDGHEMLEALRKQPDCEDISVIMLTARSQTQDIARANACGIEDYIVKPFDLSELLEKIERLVEHKKAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL9</accession>
    <name>A0A1U9NNL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69503">
        <property type="protein sequence ID" value="AQT69503"/>
        <property type="gene ID" value="STSP2_02694"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02694"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16054" checksum="3457B17F5CFEF888" modified="2017-06-07" version="1">MRLRRSDKYREPHKLNMPAMIDIVMLLLIFFMCTSNFVQPENRMQAALSRVEQGVGQQEYMDSVEIELISEADQLRIFCDGTLCDGWAGLRENLRIRREISDMDVIVRGGAGVPFENMVKAVDISHLLGFSKVGFSAKGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ4</accession>
    <name>A0A1U9NNQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_5</name>
        <name evidence="9" type="ORF">STSP2_02775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02775"/>
    <dbReference type="EnsemblBacteria" id="AQT69582">
        <property type="protein sequence ID" value="AQT69582"/>
        <property type="gene ID" value="STSP2_02775"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02775"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="77"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="277"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="45540" checksum="4D0E94BE8A864AC1" modified="2017-06-07" version="1">MQSVTAHNFKYVARDEDGLRHEGTYQAACERDVLTWARQQGLVPVKVEPVTKRSHKRKSLPVGKRISSGRMATSCWQLTTMLEGGIVLTEAIEAMAIDLKNPRFRRVLQNINEDVKSGETLSDSVAKFPNVFSPLFRTMILAGEASGTLPEVLKRMATYYEKRDRLIRQSRQAAAYPIFVFLFVFVIVGVMAFFVIPRFKLIFETINGQLPAFTQAFLAVHEQMMSNLHLVALGLLAVVLISMLYARTSLGHWQLSRIVLRIPLVGRILIRSFYALFCRTMATLLGSGVSLLEALEIVEDMTSNDVIKSAVRRTRNAITEGSGISASMQSSRFFSNTVIKMTEVGEKSGALPEVLDKTSDYYEKRVEALINTLIRAMEPILIIIVASIVLVVLIALYLPVFTISDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR7</accession>
    <name>A0A1U9NNR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PVC superphylum signature protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69156">
        <property type="protein sequence ID" value="AQT69156"/>
        <property type="gene ID" value="STSP2_02343"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02343"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026405">
        <property type="entry name" value="Chlam/Ver/Plancto_rRNA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04137">
        <property type="entry name" value="Chlam_Ver_rRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6312" checksum="7479BD0FA05A900F" modified="2017-06-07" version="1">MSIDRSLKIKSALSRHRNVLSRAERIKRLKQEDRWSEGDGVTGLPKVGNRKGPVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT1</accession>
    <name>A0A1U9NNT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Desulfoferrodoxin</fullName>
            <ecNumber evidence="5">1.15.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Superoxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dfx</name>
        <name evidence="15" type="ORF">STSP2_02686</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21324"/>
            <dbReference type="Rhea" id="RHEA-COMP:10302"/>
            <dbReference type="Rhea" id="RHEA-COMP:10303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.15.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02686"/>
    <dbReference type="EnsemblBacteria" id="AQT69495">
        <property type="protein sequence ID" value="AQT69495"/>
        <property type="gene ID" value="STSP2_02686"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02686"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050605">
        <property type="term" value="F:superoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00974">
        <property type="entry name" value="DSRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004462">
        <property type="entry name" value="Desulfoferrodoxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038094">
        <property type="entry name" value="Desulfoferrodoxin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004793">
        <property type="entry name" value="Desulfoferrodoxin_rbo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06397">
        <property type="entry name" value="Desulfoferrod_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00319">
        <property type="entry name" value="desulf_FeS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00320">
        <property type="entry name" value="dfx_rbo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrod_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Desulfoferrodox" evidence="13">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13802" checksum="771814E2C0EF6E21" modified="2017-06-07" version="1">MAERLEVYKCNICGNIVEVLNGGDGELVCCNEPMKKLAAATEDKGKEKHVPVIEKTNGGYKVKVGSVQHPMEDEHYIQWIELLADGKSYKQFLKPGDTPEAMFKVEANSVTAREHCNVHGLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT6</accession>
    <name>A0A1U9NNT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">exbB_4</name>
        <name evidence="10" type="ORF">STSP2_02696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02696"/>
    <dbReference type="EnsemblBacteria" id="AQT69505">
        <property type="protein sequence ID" value="AQT69505"/>
        <property type="gene ID" value="STSP2_02696"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02696"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012278997" evidence="8">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="109"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="255" mass="27951" checksum="D6B846EA59065FD0" modified="2017-06-07" version="1" precursor="true">MLGKRIFRITARQRVLLTLCLAMLCVATAFGAEDGDQETRISLWSTIAAGGIIGYIILLTSLVVLALVVEGFINIRHEKLIPTGLADDVRENLRMGEYQRAKEMCTEDDSFLGRVIAAGLNEVNSMFGFFDMQNAMQEVSERNISKLYRRLDYLSFIAAVAPMMGLLGTVTGMIRSFNQIALTEGAARPSELAGGISEALVTTCLGLVVAIPAMFFATFFRNRIDNFVAEAEIEVERLMGRFRKGKTENTGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT9</accession>
    <name>A0A1U9NNT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT_5</name>
        <name evidence="3" type="ORF">STSP2_02774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69581">
        <property type="protein sequence ID" value="AQT69581"/>
        <property type="gene ID" value="STSP2_02774"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02774"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="352" mass="39307" checksum="E51276986C3E02F7" modified="2017-06-07" version="1">MNIETSMQELLGKLSSTIGASDLILTAGQPPQIRIKNEIVSLDFPRLSIDDTYRLSTSVLDEEQKEKFNQDKELDLSLEIDGAGRFRINMFRQRGAAAFVARSVMSTIPTFEELGLPDIMYRLGSLQRGLVLFTGPVGTGKTTTIASLVNYINQTRACHIVSIEDPIEYIHTHIKSTVNQREVGTDTHSFKEALRRILRQSPDVIVIGEIRDRESAQAAMTLAETGHLTLATLHTRGCPASVTRLVDMFGQDQHQQVRSQLSASLAAVIWQQLILSEQEDRLILATEIMTATPAVRSLIRQGRMHEIYSLLQSGKKNGMHTMEQSIRELISRGLLDANWLNDNYSDVYAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP22</accession>
    <name>A0A1U9NP22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02843"/>
    <dbReference type="EnsemblBacteria" id="AQT69649">
        <property type="protein sequence ID" value="AQT69649"/>
        <property type="gene ID" value="STSP2_02843"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02843"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20391" checksum="5A70402CACFB13E2" modified="2017-06-07" version="1">MDLRQKKLLLKIAKNSVESAVTGSSNEPPKVDDPDLLQQCGCFVTLKNGNQLRGCIGQFTSDKPLADLVDEMGVSASRRDPRFLTNPITPEELPELNIEISVLSPLEKTGNPLSLEIGTHGIYIISGLSSGCLLPQVAVETGWSKEEFLSYCCQYKAGLAPDAWQDPATDVYLFTAEAFDEDWQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP37</accession>
    <name>A0A1U9NP37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dockerin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69681">
        <property type="protein sequence ID" value="AQT69681"/>
        <property type="gene ID" value="STSP2_02876"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02876"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504952" description="Dockerin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="753" mass="81250" checksum="7A5288F01CD695F0" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP71</accession>
    <name>A0A1U9NP71_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysE</name>
        <name evidence="6" type="ORF">STSP2_02790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02790"/>
    <dbReference type="EnsemblBacteria" id="AQT69597">
        <property type="protein sequence ID" value="AQT69597"/>
        <property type="gene ID" value="STSP2_02790"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02790"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="33567" checksum="C1E55EFDDE6C27CA" modified="2017-06-07" version="1">MDKATNKLVDSILETYEGDSGINFIDVTNLPVKSKIVEIFDMLMEIAFPGYTGKRRIARDSIRYTVGDIVCRVRHELAEQIERALKHKCRLKPCPGCDCHEMAVKITEELLNQLPNLREVLKGDVQAAYDGDPAAESFEEIVISYPFIHAITAHRIAHELYVRDVPLIPRMISENAHSKTGIDIHPGARIGRNFFIDHGTGVVIGETTEIGENVKIYQGVTLGAISFPKDERGEIIRGQKRHPTLEDDVTIYAEATILGAVTIGKGAVIGGNVWIKKSVEPGKTIAMKSTKVLERGPGGKSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP95</accession>
    <name>A0A1U9NP95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69762">
        <property type="protein sequence ID" value="AQT69762"/>
        <property type="gene ID" value="STSP2_02959"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02959"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527458" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26331" checksum="6DA10513751DD413" modified="2017-06-07" version="1" precursor="true">MKKIGLLLMVMAVVFAAGNVHAAFAIRDSGNFVSTLDQIEGDVDPATLGDWSATSYGNPFTAVNGDGTLTLVTSGYETIEHDASNDNFDSAVGWTWETRFRIDSANAENKGVWEVFVRDNDSGLAATRIHFLSTGIDPDSSGNGVDAEVAADLTDGFHVIRGAVEGGTNATTIWLDGVKVYDAMVSSDYNASEFSKIGRWGAQTGGGTATIDYIRFDTTGAYAPVPEPITMTLFGLGGIAVLRNRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA8</accession>
    <name>A0A1U9NPA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_6</name>
        <name evidence="9" type="ORF">STSP2_02831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02831"/>
    <dbReference type="EnsemblBacteria" id="AQT69637">
        <property type="protein sequence ID" value="AQT69637"/>
        <property type="gene ID" value="STSP2_02831"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02831"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="69"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="44223" checksum="501C6E03CDCF7806" modified="2017-06-07" version="1">MARFAYTAINHNGKTVKGTVTAESPFSARKHLRAKGIHPTGIKQAPREEQSASIKRIFKKNSKAQVTEFTRQLSTMLNSGIKLTEAISVLVQQLSDEEFKHAITDLRDRVISGESFADILGEYPQYFDVIYVNMVRVGEVTGTLSESLATIADFMEKRRRVESKMFTAMIYPMILITACTIAVFILTVFILPKIIEQIPTKELPWITEAMMKTSEVMRSPWALAIFGGIAVIITAYKKFVKTPRGARIRDKFLLSLPMFGPLIRQRIIARFASTLSTLLGSGLSMAESLKIVAQVSGNTIMADAITRSRERILSGADIATPLRDSGVIDPTIAHMVTVGEKSGELEQMLMSISQNLESNSDVVIERLSAALEPVIIVGLVIVVGLVVFATILPILQYSSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA9</accession>
    <name>A0A1U9NPA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69574">
        <property type="protein sequence ID" value="AQT69574"/>
        <property type="gene ID" value="STSP2_02767"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02767"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="235" mass="25879" checksum="FB98D9E32E2F3B15" modified="2017-06-07" version="1">MANIDFVPTDYIEQKESSRANLLCLVLFAAIMGGVIATFSIIKVRQKAVSADLEEINSKLVTAQKQIAQLEEISTKKKSMMKTAVMTAELIEPVPKSVLLACLTNNLPSSVSLLELEVEAEEVTVKQAASAKESKTQYQKAAKKAKAKAKTIVKKVINNKLEITGVAPSDIEVANYIASLTDSILLDRVGLVESKEYQLDGINYRQFRLNARIKPDLKLSKEDIDTIRLKKNGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ4</accession>
    <name>A0A1U9NPJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">STSP2_03039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03039"/>
    <dbReference type="EnsemblBacteria" id="AQT69841">
        <property type="protein sequence ID" value="AQT69841"/>
        <property type="gene ID" value="STSP2_03039"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03039"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20616" checksum="23D46A839D500AF9" modified="2017-06-07" version="1">MSRYKDLYKSKVRPGLQEKYSYKSPMAVPRIEKVVLSMGIGMAVHEKKYLDNGIKDMTAIAGQKPMVCKARKSVSNFKLREGMPIGLKVTLRKARMYEFMDRLINLTIPRVKDFRGLNPKGFDGRGNFSMGFVEQSVFPEIDAANIDTPQGVNITFVTTADSDEESYDLLKLFGMPFRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL0</accession>
    <name>A0A1U9NPL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplC</name>
        <name evidence="9" type="ORF">STSP2_03051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03051"/>
    <dbReference type="EnsemblBacteria" id="AQT69853">
        <property type="protein sequence ID" value="AQT69853"/>
        <property type="gene ID" value="STSP2_03051"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03051"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="22798" checksum="E675D2416BA8A30C" modified="2017-06-07" version="1">MAMLLGKKIGMTQVYDEEGKIAAVTVIQAGPCVVTQVKTPETDGYSAVQLGYDDVKKSRVKQAAAGHAKKANTTAKRFIREWRLDEGTEPEVNLGDEVTVSAFAEIKSVDVVGTSKGKGFAGVMKRHGFGGFPQSHGTKRMHRHAGSIAGHSSDAGSGGNVKKGKRMAGQMGCDRVTSKNHQLVGIDEEKNLLIVKGSVAGASGGYVEIRASKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP0</accession>
    <name>A0A1U9NPP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannosylglycerate hydrolase</fullName>
            <ecNumber evidence="8">3.2.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mngB_5</name>
        <name evidence="8" type="ORF">STSP2_03002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.170" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03002"/>
    <dbReference type="EnsemblBacteria" id="AQT69805">
        <property type="protein sequence ID" value="AQT69805"/>
        <property type="gene ID" value="STSP2_03002"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03002"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="7">
        <location>
            <begin position="367"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="983" mass="111541" checksum="8D41F2041C28DAAD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR8</accession>
    <name>A0A1U9NPR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69921">
        <property type="protein sequence ID" value="AQT69921"/>
        <property type="gene ID" value="STSP2_03121"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03121"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="18860" checksum="B39E9B18B9CC7C30" modified="2017-06-07" version="1">MKEHDFEKMFEGVESRASEAFEREVLANSSRVLRRKCFVRRAVRWGSYAASLLLVGLIAFSAGRAQTGAGTAGAEHDRGAVADSGDERVDEDMVRIAVPREFLAWVDAGRFFTSIQMEDRAGEAFDRAISLVPIEEDMMIAEEAGGDRAVDGDGRRGGVLAGIDGAFLSNVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR9</accession>
    <name>A0A1U9NPR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69932">
        <property type="protein sequence ID" value="AQT69932"/>
        <property type="gene ID" value="STSP2_03132"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03132"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11355" checksum="A5862AC6E21B6551" modified="2017-06-07" version="1">MKNCDCRSCAKFEKVCSGRTDLGGCIGWVEQSVVFTGGGTSGSETKKPLSSMQVWGEDGVEVGVRPDIEAINTRCPHVGGRHCDAWDGSRCLYEGGCLYDESEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT2</accession>
    <name>A0A1U9NPT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02994"/>
    <dbReference type="EnsemblBacteria" id="AQT69797">
        <property type="protein sequence ID" value="AQT69797"/>
        <property type="gene ID" value="STSP2_02994"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02994"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160473" evidence="2">
        <location>
            <begin position="27"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="272"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="767" mass="85358" checksum="03527C4A3E6AA07D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT7</accession>
    <name>A0A1U9NPT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03152"/>
    <dbReference type="EnsemblBacteria" id="AQT69952">
        <property type="protein sequence ID" value="AQT69952"/>
        <property type="gene ID" value="STSP2_03152"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03152"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7879" checksum="277F2DF31D62E2BC" modified="2017-06-07" version="1">MLGRKKKDREGKEKKGIVCPKCGCADLRYADGRPWNVLKTVPGANSIRRRRVCRNCGKYVWTREVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW0</accession>
    <name>A0A1U9NPW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent isopropanol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ORF">STSP2_02738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.80" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02738"/>
    <dbReference type="EnsemblBacteria" id="AQT69546">
        <property type="protein sequence ID" value="AQT69546"/>
        <property type="gene ID" value="STSP2_02738"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02738"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050009">
        <property type="term" value="F:isopropanol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="37908" checksum="E63D98261B1BA248" modified="2017-06-07" version="1">MTAESMKAFVMKKIGSVGVVDKDIPEPGPNDALIKTTAALVCTSDVHTVSGAIGEKTNRTLGHEAVGVIEKLGDAVEGFSQGQRVAVNAITPDYRCDNCLRGYTSQCTTMLGGWKFANMKDGNMAEYFLVNDAQANLALIPDELTDEQAAYCCDMLSTGFMGAEHANIPIGGTVAVFAQGPVGLMATAGARLQGAGYVIAVESIPERQELAKKYGADVVVDYTREDPVEKIMELTDGAGVDSAIEALGAQVSFEGCVKVTRPGGTISNIGYHGEGDYIELPRMAWGVGMSDKTIRTGLCPGGKERMARLMRLIQNGRVDPTLMTTHRFGFDEIEKAFEMMKTKEDGIIKPLITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ33</accession>
    <name>A0A1U9NQ33_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ORF">STSP2_03026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03026"/>
    <dbReference type="EnsemblBacteria" id="AQT69828">
        <property type="protein sequence ID" value="AQT69828"/>
        <property type="gene ID" value="STSP2_03026"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03026"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="24384" checksum="B9A7EB01D6DB9365" modified="2017-06-07" version="1">MGRYLGSSCKHCRREGMKLMLKGARCETGKCAVERRERHMAPGMHGWRRGRGSDYGVRLREKQKLKRYYGMQDKQFMRYFREAERLKGNTGVNLLQLLECRLDNVVYKLNFAPSRKAARQIVSHGHIYVNGRRVNIPDFAVTVGDKITVKNSDRSRKTIKDQLATNPNYTTQQWLQLNADKPEATMVSMPTRDDIQLVVEEQLVVEFCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ52</accession>
    <name>A0A1U9NQ52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03265"/>
    <dbReference type="EnsemblBacteria" id="AQT70063">
        <property type="protein sequence ID" value="AQT70063"/>
        <property type="gene ID" value="STSP2_03265"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03265"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="587" mass="62409" checksum="072B7AF6FF2FA5E4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ55</accession>
    <name>A0A1U9NQ55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-pyruvate aminotransferase AlaA</fullName>
            <ecNumber evidence="2">2.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alaA</name>
        <name evidence="2" type="ORF">STSP2_03117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03117"/>
    <dbReference type="EnsemblBacteria" id="AQT69917">
        <property type="protein sequence ID" value="AQT69917"/>
        <property type="gene ID" value="STSP2_03117"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03117"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48841" checksum="07A4B541247F1EA2" modified="2017-06-07" version="1">MRRDIVHEGSGQLKYEIREIVAIAKQLEQLGVPITWENIGDPVIKGEPVPAWIKEIIGELAAQDTTYGYVPTQGVVETREFLAQKVNERDGCKITPDDILFFNGLGDAVARIFGYLRREARVLGPSPAYSTHSSAEAAHSGYEHLTYELDPSNGWMPDLQDLENKVKYNDSIAGLLLINPDNPTGSVYSRELLEQMIDIARRHDIFVICDEIYSHIVYNGAKTTHLSEVIGDVPGIALRGISKEYPWPGGRCGWLEAYNQDKSPMFAQYINTIIHAKMLEVCSTSLPQYSIPRVIGDPRYPDHLERRAKMFEHRAIQAHEILSKVPGINVVKPQGAFYMSVTFDEGVLNDNQHLSVENTAAREYIESLVPSLEVDKRFVYYLLAAHGICVVPLTGFCCKRKGFRVTLLECDDEKRKWTWQTIAESIHTYLNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ62</accession>
    <name>A0A1U9NQ62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dpnA_2</name>
        <name evidence="5" type="ORF">STSP2_03275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="191340">
        <property type="entry name" value="M.PbaBD1ORF3275P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70073">
        <property type="protein sequence ID" value="AQT70073"/>
        <property type="gene ID" value="STSP2_03275"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03275"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021451">
        <property type="entry name" value="DUF3102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11300">
        <property type="entry name" value="DUF3102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="49169" checksum="4862019D1F30E12F" modified="2017-06-07" version="1">MESRKKNTGKKRNVERNLVSRINTLHSECENTYRRAVETAIEIGQLLTQKKLELEHGEWGKWVESNLAFTCRTASNYMRLYENQNKPELQKCKGVFEALSYLKEETNKNRTKTRQATKEYRRAYADMDLDYDNPPAGQYENKVIAGHNCQVMQEMLNHGMMAKYSAVLGSPPYNVGMFYSSEYDDEKAFDTYMNAIAEPFKYYPDLLRQGGRVIYIVPTFLENKHRDISGDYNYDFPYELRKRVEKVAPSLRFFGHIIWDKGDKAKNPINKKYGSFCSPERPSMRVGHEQIMIWSNEQFTLSSPEGIKPDITEETFLELSWTIWNIAPLVYKNNPHPCSYSSKLAESLIQFLTFPSDWILEPYNGSGVGCKAAQLLGRKFTGVDLNKNYCVYAKALLDAEKYTVSKARMKTILKGHKSLWKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD8</accession>
    <name>A0A1U9NQD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative siderophore transport system ATP-binding protein YusV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yusV</name>
        <name evidence="5" type="ORF">STSP2_02922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69726">
        <property type="protein sequence ID" value="AQT69726"/>
        <property type="gene ID" value="STSP2_02922"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02922"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29281" checksum="176A27D878277263" modified="2017-06-07" version="1">MSMIEIHDLCFSYGQTGILKDLSVSFDQGTFWAIGGPNGAGKSTLLNLMCGALRPESGHILIEGERLSDLNTRNVASRIAVVRQEYVPAFEFTVAETVALGRTASLRGAGFETASDKTAIEEAMKATDTLRFADRSLAHISSGERQRVFIAKALAQNTPIILLDEPTSFLDLKHQVEIYDLLKHLQIAKNKTIVTVTHDLNLSRQYCDHILLIGAGLDYCFGKCGDILTKDRLAKYFNVDGIALKCGGCDFFLPVGDMSSLAAEKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI2</accession>
    <name>A0A1U9NQI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70169">
        <property type="protein sequence ID" value="AQT70169"/>
        <property type="gene ID" value="STSP2_03374"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03374"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12068" checksum="0CACAD14A8614363" modified="2017-06-07" version="1">MNIVLATVPQNLVLAVRREIVQYQVYPLVRRILFPGQFQNFQELLMPLAWPNISPELFLMDIVKRQPVLNAVFAGIGRRQPLGMVGMTVILARLRTNLQRSELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI5</accession>
    <name>A0A1U9NQI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI</name>
        <name evidence="2" type="ORF">STSP2_03189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03189"/>
    <dbReference type="EnsemblBacteria" id="AQT69988">
        <property type="protein sequence ID" value="AQT69988"/>
        <property type="gene ID" value="STSP2_03189"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03189"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14729" checksum="A922DAF203BAC35C" modified="2017-06-07" version="1">MPRKQSQKENSRPSELELQVLSVLWDKGPASVRDVMNSLPDGKQRAYTSVLSVMQVMEKKRLLTHTRQGNTHIYKPTKPRRAVVDPLMKRLASNIFNGSKVSMVQSLLGSEKLTDAELAKLEQLIESKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ4</accession>
    <name>A0A1U9NQJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70203">
        <property type="protein sequence ID" value="AQT70203"/>
        <property type="gene ID" value="STSP2_03408"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03408"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35626" checksum="87EBA9A0C9467E71" modified="2017-06-07" version="1">MAKRKKKKQNKSGGLFGFIGVGSQKKRKKRKTKAEKKESRERTVYRLKMGFAMLFGLALFAGIAVGFVVLERYVKQVSPVAEKAGPIKLDSPDWFATTPAIKTAVTDKLGGRNFKLNANTAEAIGLALEDLPWLYNVKAVMTNESVQVTADYRKPLAIVEIRGKQFHLAWQDETVPKEQRKLYLLPYVSIDSIHSVNITGFDAVGRPKAGEVLQSRQVGAAVRIIELLRIMDKKICPQNPLLHEIVSIDVSNYAGHRDAPRIVLYSEDGIAVNWGAPVGEGESNFEPGYVKKLTALYEVYQLRQMTLEGNKFIDLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK8</accession>
    <name>A0A1U9NQK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="1">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hcpC_5</name>
        <name evidence="1" type="ORF">STSP2_03209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70008">
        <property type="protein sequence ID" value="AQT70008"/>
        <property type="gene ID" value="STSP2_03209"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03209"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="422" mass="46743" checksum="1FDD196E419A49F8" modified="2017-06-07" version="1" precursor="true">MRLDRLLLVALITVTAIVSISQAFDEPGPVVKRVIESANEGDPDSMFVLGYMYQEGDDGVEKDLDKAHEWFKKAADKGHVEAMIALAFMYQKGDPVRPDPYRTIYWLQKAAEKDDANAMFYLGELYHRGKGVAVNLPEAVRWYKKAARAGEPHAMYWLGDMYKNGTGVQQSDEQTYHWFQKAAEAGDISAMYYLATMYEEGVGTDQDIDKAVKWYEAAADEGNSDAMYSLGTLAREGRGMPRDIDAAVEWFSKAAKQGNSDAMLQLGLMFDNGEGVALDPEKAVKWLEKAAQGGNLRAMQLLGLKYLNGDTVGKDLEKAANLLLPPANDGLVKAMLALAEIYRSDSPFMQDKDKAVEWVRKAAQAGNLTAILDLAQMYLKGEGVEQDKEKALAWYKKAADKGSDVAAEKVEELEDKGLLNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN6</accession>
    <name>A0A1U9NQN6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">STSP2_03447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03447"/>
    <dbReference type="EnsemblBacteria" id="AQT70241">
        <property type="protein sequence ID" value="AQT70241"/>
        <property type="gene ID" value="STSP2_03447"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03447"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="35241" checksum="3D2CE6E5A7EC226D" modified="2017-06-07" version="1">MIRSSNKFKWRHKHLLGLRELTREELEFILDTAEGFENISTRSVKKAPPLRGKVVVNLFFEDSTRTRISFGLAASRLSADVVEFTKKSSSVSKGETLIDTARNLEAMGIDTIVLRHGAGGAARLLSRSIDACVVNAGDGFNEHPTQALLDVYTIRKHRGSLDGLKIAIVGDISHSRVARSNIWAMTKLGAEVILVGPPTLMPSKVNDLPVTVSYDMDEVIEKVDVINMLRIQFERMGGNLFPTIREYARFFSLTVDRMARAKSDLIVMHPGPINRGVEIESEVADGNNSVILQQVSNGLAVRMAVLYLVNQAAANKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX7</accession>
    <name>A0A1U9NQX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70319">
        <property type="protein sequence ID" value="AQT70319"/>
        <property type="gene ID" value="STSP2_03525"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03525"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="34490" checksum="2CEF673BBDEDA74A" modified="2017-06-07" version="1">MERYISDEELRRQAWKYWVVVLAWPVYLFCIPAVFDAFGWWAVLLMVWSGAWLYTWIGCLMHECWHKYVPNVPNEGLYKVYSWMLGTDPQNYRLVHGFHHSKVNSWEDTEFHPVGEVREGWRRRMYNAAEILLGVIWTFGLLTAVLGFHERYREKWRLRSLLVSLAAVTVFYGGIGTAAVFVWGVAVWQAVVAIGLSFWLGAFWVHQDQLVQHGGLIVEGDVKERNIRSRNLRRETVWEKAFLFMVHGDCREHVLHHTNVREHSRVFADRMPLPEGAVVITLGDYGRVLWGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ7</accession>
    <name>A0A1U9NQZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">STSP2_03451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03451"/>
    <dbReference type="EnsemblBacteria" id="AQT70245">
        <property type="protein sequence ID" value="AQT70245"/>
        <property type="gene ID" value="STSP2_03451"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03451"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="45325" checksum="6405670807D26915" modified="2017-06-07" version="1" precursor="true">MNLICNKSRIKGRVPVPASKSHTIRAVAVASLAHGRSIIQKPLVSSDTLSSVECYRKLGAEIDTSSNDAWIVDGTEGRIPVSSARIDVGNSGTTLRLAISSAALADEGTFYFTGDKQIRSRPIQPLLGALNDLGARAESVNGDGKAPLEVTGTLRGGKTHIECPTSQYLSSLLMAAPLAGGETEIEVGLLNEPDYVRMTLDWLDRQGINYENDNMKRFHITGGQRYSAFEGRVAADFSSATFLLCAGAILDADILLTGLDFSDSQPDKAVVDYLRKMGADITVGPEGVAVRNSRLRGVEIDMNGTPDALPAMAVTAAFAEGETRLVNVPQARNKETDRIDCMARELAKMGASVEQLPDGLIIRGGGVRAAQVDGHHDHRIVMALAMAGMAVEGETVITTAEAMNVTFPDFVTLMDRLGANLRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR13</accession>
    <name>A0A1U9NR13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">STSP2_03559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03559"/>
    <dbReference type="EnsemblBacteria" id="AQT70353">
        <property type="protein sequence ID" value="AQT70353"/>
        <property type="gene ID" value="STSP2_03559"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03559"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="19049" checksum="3E14F0068EFB405D" modified="2017-06-07" version="1">MVDVQSCELTKYPAGVLGEKAKPVEEINDNIRQLAEKMVDIMIESKGVGLAGPQAGVNLRIFVASEDGTRDKSKVYINPEIELSGKVIADEEGCLSLPGIYAKMRRYEKATVTATDLQGNRFTETGEGLKARIFQHECDHLDGTMIKDKLNRVQMISAKKKLKRLEEDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG24</accession>
    <name>A0A1U9NG24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ORF">STSP2_00020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00020"/>
    <dbReference type="EnsemblBacteria" id="AQT66882">
        <property type="protein sequence ID" value="AQT66882"/>
        <property type="gene ID" value="STSP2_00020"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00020"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="607" mass="67659" checksum="6DFCD128C87C5774" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGD2</accession>
    <name>A0A1U9NGD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66992">
        <property type="protein sequence ID" value="AQT66992"/>
        <property type="gene ID" value="STSP2_00130"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00130"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24868" checksum="CE7481CE248C04F2" modified="2017-06-07" version="1">MTANTQHQTQHPNAERYDFKVIGQDQTGRIIDHYFQIVASKESQAEKHLQSIFKNNSGIKKWTVLKKRVLPTTAEQKRTYENEGTFCLTGDQIQYRPGNVRDYKLAGSAIIGFGAFLAIISLGAGIIHFLILGSIGIYLMRSFSLGAAQLLLVFCVLPLIIGTIQVINHILKHGWELSQSLKQPHILILNTAFVLFIIVITILLIRLLCKAHYGKNEATKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH23</accession>
    <name>A0A1U9NH23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67233">
        <property type="protein sequence ID" value="AQT67233"/>
        <property type="gene ID" value="STSP2_00376"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00376"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25329" checksum="A2ADA8226396DAF5" modified="2017-06-07" version="1">MLKQLFRNLKRLTQHETQVDPSRFNDPVAMHTKWTPAKGGGTNMCTHRLTTIGPNRVEIKSTIGVKIFAAIFLIIGLAVGIGVGIAGDGEERLFALILGGIFALTGAALLYYYSRPIVFDKTVGWFYKGKKAGPDLLRSSAEPPKDAARLSDIHALQIISEYCTSRGKNHTTHYYSYELNIVQKDGRRINVVDHGKLDKLTDDANALAAFLGVPLWNAEQQDEYGLAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH58</accession>
    <name>A0A1U9NH58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67088">
        <property type="protein sequence ID" value="AQT67088"/>
        <property type="gene ID" value="STSP2_00228"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00228"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5361" checksum="223FF6EE58DF1AA5" modified="2017-06-07" version="1">MLLRGRFGVKKGFSKVGGGYRSRHGPITGKAVQKVKIFMKNSACKFAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA4</accession>
    <name>A0A1U9NHA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00328"/>
    <dbReference type="EnsemblBacteria" id="AQT67185">
        <property type="protein sequence ID" value="AQT67185"/>
        <property type="gene ID" value="STSP2_00328"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00328"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19825" checksum="F1AC04C064AC728D" modified="2017-06-07" version="1" precursor="true">MKTVGNTLKMAVISLIIAVSAVSMVGCVGSAGDYSNTWVYPENVASVYVEMFDTRSFRRGFEYTLSDAVMKRLEAETTYKIVSDRDLADTVLTGQVGRLRAGTLARDRETGRPLENEAFVTVQVSWKDLRSGELLINNQEIAASAPYSTFLGQDFDYASRVAMNRAAQKIVERMQVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA9</accession>
    <name>A0A1U9NHA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66990">
        <property type="protein sequence ID" value="AQT66990"/>
        <property type="gene ID" value="STSP2_00128"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00128"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26425" checksum="2038BD7D488B349B" modified="2017-06-07" version="1">MLWQYDFLVRGKTGGWSEQAADKEQTPEDTDNTEPGQATNPDAFPEAAQYQRPMLRLEHIYSVVAKSEKQAEHCLTDTFKSAKGVDSMRLIRRTAKKQILPDDERVTKYEQIGPFVILDTPMEFTSYDQSCRGCGISATILGMAACVLALIIYIEEALWLPWLLAIPVTISGIWMIDGSRIGLKCAAASHAILITLTAFATVVFLIKEGVLALLALLITVWASINLILMLSTLMQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH4</accession>
    <name>A0A1U9NHH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67060">
        <property type="protein sequence ID" value="AQT67060"/>
        <property type="gene ID" value="STSP2_00200"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00200"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3367" checksum="E36236F4B603FA2D" modified="2017-06-07" version="1">MDLATTNISMIQAEILDMHSMVVGCKKVICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR3</accession>
    <name>A0A1U9NHR3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdJ</name>
        <name evidence="14" type="ORF">STSP2_00608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00608"/>
    <dbReference type="EnsemblBacteria" id="AQT67461">
        <property type="protein sequence ID" value="AQT67461"/>
        <property type="gene ID" value="STSP2_00608"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00608"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="62"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="194"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="923"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT67461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113002" checksum="F89CFAFA3F805ED0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU1</accession>
    <name>A0A1U9NHU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alkyl_sulf_dimr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67491">
        <property type="protein sequence ID" value="AQT67491"/>
        <property type="gene ID" value="STSP2_00639"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00639"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl_sulf_dimr" evidence="1">
        <location>
            <begin position="64"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="23205" checksum="466B8870F7418859" modified="2017-06-07" version="1">MYRDIRSWASSVDMMIKEKPEYLVGGHTRPIIGGEKIIEVMTNYRDAIRFVFDKTIEGMNKGMTPDELVDYARLPDRLAEKDYLREYYGNVEWAVRQIFNAHLGWFDGNPTNLFSLSPRQEAIRMAKLAGGEAELLQQAQRAVKSKDNQWAAQLADHLIALNPDASEPKLIKAEALEALAENLLTATGRNYYLTAAQELRKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU4</accession>
    <name>A0A1U9NHU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein NlpI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67314">
        <property type="protein sequence ID" value="AQT67314"/>
        <property type="gene ID" value="STSP2_00457"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00457"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26536" checksum="83EDD61E7EE7B3B4" modified="2017-06-07" version="1">MANASKLTGLILTAVFLVAGCDMFGGAQKDKEEPVVISSEQRKTELLEKIEKDYDNAELHYELGKIYQADGLWQKAETQFSRAIGFDPVHRKAEAALVKTLTLAGEEDRAAPLAKNYLSQAQYSPEASLRLGRAFQQEGLNDYAITAYKQALDLAPNSAGLNKQIGYYYLAQGDKVRAEEYLRRSFQLNPNQPEVAGELGRMGVIVQVPKEKKTSGSQLDKLIDKLFGGGDEEQGQQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW4</accession>
    <name>A0A1U9NHW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase (URO-D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67405">
        <property type="protein sequence ID" value="AQT67405"/>
        <property type="gene ID" value="STSP2_00549"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00549"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="373" mass="43568" checksum="994FD2C20543AD1B" modified="2017-06-07" version="1">MSVKPCREKWPGKMTDRERFNNQMHYKPFDRCFNMEFGYWDENFKEWDIFVEKGIKDNSQAHEFFNFDRIELHEYPWMVPPFEQKVVEETEDKKIIINQDGLLAEVPKNDQTTIPHFIKSSITTPEDWKKCKNERLRRDDPARKPDIEALKKLYPADRDFPVGIWCGSMIGKIRDLLTFEGLAYATFDHPGMIEDMVETCCVLVEDYLDAVLGHIDFDFAWGWEDICFKSGPIVSVDFFKKVVAPRYKRINEKLKAHGIDIWFTDCDGDIRPILPTLLESGINTMFPFEVNCSGHPTELLAEYGKDLRIMGGFDKMALGEGPDAIRSYMESLIPYVERGGFIPFCDHRCPPNVKPEDYIFYLDLKQKTFGQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX7</accession>
    <name>A0A1U9NHX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67348">
        <property type="protein sequence ID" value="AQT67348"/>
        <property type="gene ID" value="STSP2_00492"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00492"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29809" checksum="660EF09E94D2F65A" modified="2017-06-07" version="1">MSRDMKVAIWSVGVFALLMGVVCIVLWWIWPHSGYLMAKNVAELDNWYGGFFYFGWMYVVMVWLGIGLIFLLFQLIMMFLGGVERGGKRVLTALSALLVGAVIFISPAGGWFLPVRHPSPVIRGLVDGAEQNLEAAELVAWIDEKRNELPAEEKWVYLVQQEYFEPADMDLNQAIFMQAKDLACLRLEWGNAFMDWGYIVSNREDKFIVTDDDYIMQAGPNVVAWRELRGSRVEPNPQGIDVVVLEWDDSVCDWRVREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI58</accession>
    <name>A0A1U9NI58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_ISL3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00575</name>
        <name evidence="3" type="ORF">STSP2_01448</name>
        <name evidence="4" type="ORF">STSP2_02486</name>
        <name evidence="5" type="ORF">STSP2_02667</name>
        <name evidence="6" type="ORF">STSP2_02855</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67428">
        <property type="protein sequence ID" value="AQT67428"/>
        <property type="gene ID" value="STSP2_00575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68290">
        <property type="protein sequence ID" value="AQT68290"/>
        <property type="gene ID" value="STSP2_01448"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69297">
        <property type="protein sequence ID" value="AQT69297"/>
        <property type="gene ID" value="STSP2_02486"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69476">
        <property type="protein sequence ID" value="AQT69476"/>
        <property type="gene ID" value="STSP2_02667"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69661">
        <property type="protein sequence ID" value="AQT69661"/>
        <property type="gene ID" value="STSP2_02855"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00575"/>
    <dbReference type="KEGG" id="alus:STSP2_01448"/>
    <dbReference type="KEGG" id="alus:STSP2_02486"/>
    <dbReference type="KEGG" id="alus:STSP2_02667"/>
    <dbReference type="KEGG" id="alus:STSP2_02855"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="38960" checksum="073ADEAF6AB37A14" modified="2017-06-07" version="1">MRHKGSKSYEFITKRGNISLTGTYYHCSCGSSKPISNLVSSGRKYSRIANELVLRHTASGPYKEVSRFLRQDFSIHISHESLRRRILAVSGSIRQNRDCSSDDRKWDEIAGSKLYGYADGVLINVRREGWKEVKLLRYEDDACSKVSHRAVLGPIKQFGSLARREAIRIGASKAKDMTFLMDGAEGFHRHIKSNLPNAKQVVDYWHCCQHIGECASLLYGENSKRSNRWRSKYCHVLRDKGPKKLIRSLRISKSRVASSEDAEALSKLINFLSRRIERIDYPKLLAMGLRVDSGPIESSCKTVVQARLKSSGMRWSRQGASAMLEVRTALHSDLWEYAIKDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI84</accession>
    <name>A0A1U9NI84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ruvA</name>
        <name evidence="9" type="ORF">STSP2_00779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00779"/>
    <dbReference type="EnsemblBacteria" id="AQT67631">
        <property type="protein sequence ID" value="AQT67631"/>
        <property type="gene ID" value="STSP2_00779"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00779"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RuvA_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22486" checksum="D8FD5A11568BDBCD" modified="2017-06-07" version="1">MIAQIEGKLTSLTPESGLLKVGPISYEIMLPGYAVSQLAGQINSDVSFYTMQYLEGSPGGGNLLPRLVGFLSEAEREFFHQYTSVKGMGIRKGLKSLTLPVATIAGAIESGDEKLLKTLPQVGKRLAQLMIAQLQGKLEGYAVGETTAAGGGGGASFANYQVEALEILVAWGEKRAEAMELIELASNKHPDVKSAEELVPLVYKIKQGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB1</accession>
    <name>A0A1U9NIB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67464">
        <property type="protein sequence ID" value="AQT67464"/>
        <property type="gene ID" value="STSP2_00611"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00611"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13880" checksum="929AF081CB10D399" modified="2017-06-07" version="1">MDLEQVFTIAPMLGMAVYIFLMRRNRKKHGLNKKNSLLITKKPPYKLMLFAILSGLAMAAVSMYVLVKDGTLDADVAILSLSLTAIFGLGVFMFFRVMAQRELKKAEQLEDNDETEQNPQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC3</accession>
    <name>A0A1U9NIC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Internalin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">inlA_1</name>
        <name evidence="3" type="ORF">STSP2_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67537">
        <property type="protein sequence ID" value="AQT67537"/>
        <property type="gene ID" value="STSP2_00685"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00685"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="480" mass="53208" checksum="84B6F4F4C1DC6CE5" modified="2017-06-07" version="1" precursor="true">MNAKLLTYVCTLMLTICTCQVYGKTFNEWAQEENLSGNETQIDAYRKSITSLEGLANNFPHLQELMLHRNYLSSLYAGDFYGLSNLEELHLGSNQISSIEDGSFQDLHNLRSLTLSSNPLTEVRSSQFIGLSNLQTLKLSENQITNIGARNFQPLTNLRSLSLGHNNISSISADAFAGPSHLISLYLGFNQLNRIESDYLQDLSSLQDLDFRNNNISSIEPGAFSGLDILARLYLTNNDITSIDGTGFQNLDHLHTLELANNQLSEIGRTTFAAPRSLQTLNLAGNQINRIADEAFSNSRYLKELNLDRNNIETLNLRKANLSSLERFSIDLNPIDTVILSEIIIGQQGFNALMIGSDTYSWFSGLDRLDAINLMNFNKTDFSSVLNLSAMYGMDSLEAVSFANTSNLSGREVADLAVNLDSLNWLDVTGPWDTWSVDVQADLLAWDAVEGHELITPEPATVALLTLGSLALIRRKCSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC4</accession>
    <name>A0A1U9NIC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67484">
        <property type="protein sequence ID" value="AQT67484"/>
        <property type="gene ID" value="STSP2_00631"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00631"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="32827" checksum="59FF6246971F2E84" modified="2017-06-07" version="1">MMLPVIFICLNSYENVSAMMILRLTNKAFKKLGEKPQPVEVDEVQGSFDEWYVNTADFFNDGNLFMPVMHADSLYTMLVPIEKDMETDDFVSKVLANLMYRMLRLEIPREHAQRVMQTYGGEAILTKTKSRKTLGTLTRTGGDIRHTAEYGDGIITGKRVDLGQLESFANQTPRNLNDGYVWPLEEFYSCIRRFCPELPLRITLALGSCSWRKHSATMSVFQGRISERLYTKAKAACLDAEVLFDRSETEALLKAAHDSHESSSDIPNDVYATLSQMLSYRLGLLMSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII0</accession>
    <name>A0A1U9NII0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative domain HDIG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00773"/>
    <dbReference type="EnsemblBacteria" id="AQT67625">
        <property type="protein sequence ID" value="AQT67625"/>
        <property type="gene ID" value="STSP2_00773"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00773"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
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        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="288"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="510" mass="55909" checksum="776D2A7D0E2BAE58" modified="2017-06-07" version="1">MARKKKKISARRQHVRDTISAERLERVSKAVNSPLPAAIAVLVLFIVLATAILSVQTRALDTFFQDMWRPWSQIFSIAALVSIISLGGAMYVHHFKHRIIERAPRAIALATLFLLLLAITRAASFYSEWTYLATGSAITSAVILTIAYDQRFAIGMTTFFCILACFAARADEATTLKLFQLFLTMIAGAVTCCFALREIRTRMKLIEVTTLAAVIVMLVATSLGVLDDWTATKISKTSGAAAAVTVAVGFLIQGFLPLIERAFGIATSMTLLDYSDANQPLLKKLAMEAPGTFSHSLLIGSIAESAADSINANGLLCRVGAYYHDIGKINKPPYFVENQMGSASRHEALSPAMSQLVIVGHVKDGIEIAREYGLPAVLRQFIETHHGTTLIEYFYNEAKKQADEKGTTISDTEFRYPGPKPHSKEAAIVMLSDTCESAVRSLGDVSPTRIEAVVHNMAMKRLQDGQFDECDLTLRELSTIEETLSKSLAAHHHGRIKYPTPPDEPQKENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK8</accession>
    <name>A0A1U9NIK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine-protein kinase BarA</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">barA_1</name>
        <name evidence="9" type="ORF">STSP2_00912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00912"/>
    <dbReference type="EnsemblBacteria" id="AQT67763">
        <property type="protein sequence ID" value="AQT67763"/>
        <property type="gene ID" value="STSP2_00912"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00912"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="322"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="772" mass="84449" checksum="D7717C20715DE9D4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV0</accession>
    <name>A0A1U9NIV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">STSP2_00668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00668"/>
    <dbReference type="EnsemblBacteria" id="AQT67520">
        <property type="protein sequence ID" value="AQT67520"/>
        <property type="gene ID" value="STSP2_00668"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00668"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13421" checksum="BEAD10925663AE02" modified="2017-06-07" version="1">MVEKQVMDNKEFAFEAAKIAAGLNCTDVKVVDLRGKSPATEFFVIATSTSARQSRTVADDIDDFAEEAGHARYGRAGYDIGRWILLDYVDVVVHVFDAESRDYYQLESLWGDAKEYAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW4</accession>
    <name>A0A1U9NIW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
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            <dbReference type="EMBL" id="AQT67861.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12689" checksum="E0DACF4DF361FB19" modified="2017-06-07" version="1">MCAGLVAAGVLFEVDDVGTHFAGWKWGVHCMLDGAGGGECFWCGMSRGFAAMVKGRFSEGVEHGVAGVTLFGLVLWQGGYSVAGLWRWPRRMRKKLRTVNVVLSVAAGAVIIWGWWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67972.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
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    <sequence length="617" mass="67411" checksum="F5088758BAAA4162" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ64</accession>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ81</accession>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
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    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35875" checksum="6508A469B8E11D1C" modified="2017-06-07" version="1">MATKVAINGFGRIGRAVARIIIERAGDAELVAINDLAPAKSLAHLFKYDTNFGKWDGDVSVEGDSIVINGKKIKVTAIKNPAELPWGDMGVDVVVESTGIFRTKSSDKGGYGDHLKAGAKKVVLTVPAKDDIDATVVLGVNDDTLTADAKCVSNASCTTNCLAPVAKVLNDSFGIKRGVMTTVHGYTNDQNVLDMIHSDMRRSRAAALNIIPTTTGAAKAVGKVIPDLNGKLDGMALRVPVPTGSCVDLVAELDKDASIEDVNAAIKKAAEGELKGILAYTEDPIVSSDIIGDPHSSIFDGLSTMKMGENLVKIISWYDNEWGYSCRTVDIIEKIAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD6</accession>
    <name>A0A1U9NJD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_2</name>
        <name evidence="2" type="ORF">STSP2_00996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67844">
        <property type="protein sequence ID" value="AQT67844"/>
        <property type="gene ID" value="STSP2_00996"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00996"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31574" checksum="245BDF476B7EAB29" modified="2017-06-07" version="1">MKRKAFTLIELLVVIAIIGLLMSIMLPALGKVKEMARMTVCKTNLKQYGLAMNMYLADYNQKFPNPMTAIYKSWIPPATRNCQWHDRNTMPTVTPSNAGPLWSYLASADAHMCPTFKSIGKQYGADHFDHDEDIPIEPQYAYSQNAYLGTTHLRSSNITRMNSQVAVFVEESMWQMGQGGSKDICSHVLNDTNFFARHPNDSFGQVGDSIGTYHNNSGLSSRMEVGSQGAIQTKSGGVGNVVFADGHVDHVDPYESETINGMQFTKSYLTAYPGRDIKSKTCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG3</accession>
    <name>A0A1U9NJG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67656">
        <property type="protein sequence ID" value="AQT67656"/>
        <property type="gene ID" value="STSP2_00804"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00804"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10284" checksum="57C2F2992A79288A" modified="2017-06-07" version="1">MKSSIAVTLIICGTFLITVPYIHNDLVTHLVSQSATQLKKDINVRISAPMPEYADTACILGGITMILIGAAAGIKQTLQPQNLNENHPQNPESTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI0</accession>
    <name>A0A1U9NJI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01129"/>
    <dbReference type="EnsemblBacteria" id="AQT67975">
        <property type="protein sequence ID" value="AQT67975"/>
        <property type="gene ID" value="STSP2_01129"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01129"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24566" checksum="405380E35A8F9F66" modified="2017-06-07" version="1">MALTEIYSTSSEAFTDRRQAAQTLVEHLEEYSGSDSLVLGIPRGGVVIADCLANSLDVQMDVVLTHKLGAPANPELAIGAVSEDGHLILDDQLAAITGASRRYIEEEKAKQLEVINSRVKQYREILAKSDVGGRTVILTDDGIATGATMQAAVWAVKAEGAAEVVVAVPVGPADSLERIAEDADKIICVRSPAYFGSIGRFYQIFDQVSDDQVLKIITEQAKRRRDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK1</accession>
    <name>A0A1U9NJK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ORF">STSP2_00834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00834"/>
    <dbReference type="EnsemblBacteria" id="AQT67686">
        <property type="protein sequence ID" value="AQT67686"/>
        <property type="gene ID" value="STSP2_00834"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00834"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="100"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="473" mass="50904" checksum="C916DDD0833E3328" modified="2017-06-07" version="1">MTFTQLLTLVQESQDKIGVCSDSRQVTEGDVFVAVAGSNVDGHEYIGQAIEKGAGYVVAQREPSTNGVPVVMVDDSAKALGELAQARYGNPASRMTSLAVTGTNGKTTVAYIVRSIISCTPHKCGMIGTVQYDTTAREESASLTTPDSLQIARLTNEMVENNARFMAIEASSHALDQERLAGLKFTAAAFTNLSGDHLDYHESEEEYLAAKTKLFRNLPMHAVAVLNAGSPHARKIAAETKARVLWYGIDRHADIIASIHKMDADGTTYGLHFNGHSQPIRTKLLGKHNVANQLAAAGLCIAAGFDLNTVARGIERLERIPGRLDPVESDKPFKVLVDYAHTDDALANVLATLRPICEGELTVVFGAGGDRDKTKRARMAKVAEEKADSIYVTSDNPRTEDPGQIIDDILAGFADADKVTVEQDRKKAIELAVKNAKAGDVVLIAGKGHETYQVLGTERIDFDDREVAAAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK5</accession>
    <name>A0A1U9NJK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 109 protein 1</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67987">
        <property type="protein sequence ID" value="AQT67987"/>
        <property type="gene ID" value="STSP2_01141"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01141"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="455" mass="50906" checksum="32DA46B515E48FF6" modified="2017-06-07" version="1" precursor="true">MANSNNINRRDFFRKSSALGLTAALGGSILAGKSRAALPSIPPAGFNSKPIDLVRIGFIGAGGMGSNHIRNLMNIEGCEIRAICDIVPEKVARVQKWHRDANKPVPAGYSKGEHDYKRMCAREDLDLVYIATPWRWHVPMCVEAMNAGKHAAVEVPAAVTLDECWQLVETSEKTKRHCSMMENCNYDRVEMMVLNMVKQNLFGELLHAKCGYLHDLRDQAFSKGGEGLWRPAHNLTRNGDLYPTHGLAPVAQCMDINRGNNFDYIVSVASKSRAVNDLAARRFGPDSPHTRTNWKLGDVVTSTIRTKNGETIVVTHDVTTPRPYSRDYFVQGTRGLVRKYPEARVHIEGTSPAHGWEPLSKYFDKYDHPVWKAMQQKASGAAGHGSMDYIEDYRLVQAYRKGITPDMDVYDAAALSAVSQLSERSIENKGESVNFPDFTRGMWRKPRELQVQKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM3</accession>
    <name>A0A1U9NJM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67706">
        <property type="protein sequence ID" value="AQT67706"/>
        <property type="gene ID" value="STSP2_00854"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00854"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11658" checksum="6AAEE7F76793C518" modified="2017-06-07" version="1">MNTNVLKDIPYADDKMGKRKVVDTDDILIMQIALKPGQAVPDHNANSNVHLLIIEGTITANLDGTENTLEKGSLTPVAYKTPMQIKNKTDTPATFLVLKTPNPAKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN5</accession>
    <name>A0A1U9NJN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol phosphatase of the PHP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00939"/>
    <dbReference type="EnsemblBacteria" id="AQT67790">
        <property type="protein sequence ID" value="AQT67790"/>
        <property type="gene ID" value="STSP2_00939"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00939"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="355" mass="39910" checksum="6A9F1A702952C330" modified="2017-06-07" version="1" precursor="true">MKMRMVAGLAVVLFLVGLCGAQEYFPNIEGYETLTADLHTHTVFSDGTVWPTVRIDEAKREGIDVISISDHIEYQPHKWDIPTNHNRSYEIAKPAAEKAGVLLVKGTEITRDTPPGHYNALFIEDVDPLETDEFMDVIEEANRQGGFVFWNHHAWQGEERGKWEEVQDVMYDEGWLHGMEVANAGDYYPDAHAWCMEKGLTMVGNSDIHGPSIDYEYTAQKHRTLTLVFVKKRNLEEVEKALRRGRTTVWVGNRLVGKERYLRPLFGRMVKVVGEREAAGNTRLVEVANGGLIDLELVRPGEDGPEKIVLGARSSVEFEVAEDAEEEKFTVENMLVRPGEGLEVVIGISGAAMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN9</accession>
    <name>A0A1U9NJN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">exo I_4</name>
        <name evidence="8" type="ORF">STSP2_01294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68139">
        <property type="protein sequence ID" value="AQT68139"/>
        <property type="gene ID" value="STSP2_01294"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01294"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165689" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="161"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="531" mass="60682" checksum="279E7BF03EFC05A6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ6</accession>
    <name>A0A1U9NJQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67810">
        <property type="protein sequence ID" value="AQT67810"/>
        <property type="gene ID" value="STSP2_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00960"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3408" checksum="85B69931C33CE848" modified="2017-06-07" version="1">MTRKTKIFLYIMLALGAALMIAGVLLEQVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS3</accession>
    <name>A0A1U9NJS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xpsE_1</name>
        <name evidence="3" type="ORF">STSP2_01327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01327"/>
    <dbReference type="EnsemblBacteria" id="AQT68172">
        <property type="protein sequence ID" value="AQT68172"/>
        <property type="gene ID" value="STSP2_01327"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01327"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="317"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="569" mass="63000" checksum="15AC1ABA9E2EA49E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK21</accession>
    <name>A0A1U9NK21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death on curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">doc</name>
        <name evidence="2" type="ORF">STSP2_01082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01082"/>
    <dbReference type="EnsemblBacteria" id="AQT67930">
        <property type="protein sequence ID" value="AQT67930"/>
        <property type="gene ID" value="STSP2_01082"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01082"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018297">
        <property type="entry name" value="Doc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14481" checksum="365DB086F50C004F" modified="2017-06-07" version="1">MQIPYFLDLEQVLRLHGSLIENYGGLAGVRDMGLLQSAIAAPQAAYEGQFLYNDIFEMAAAYLYHLVQNHAFLDGNKRIGAASAIVFLAINDIQIQNDEEGLVEITLGVAKGQIGKTEIAKFLRSNVIDPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK32</accession>
    <name>A0A1U9NK32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01253"/>
    <dbReference type="EnsemblBacteria" id="AQT68098">
        <property type="protein sequence ID" value="AQT68098"/>
        <property type="gene ID" value="STSP2_01253"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01253"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843867" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="246"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="579" mass="61514" checksum="8EE1A269265DC6FA" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK35</accession>
    <name>A0A1U9NK35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01330"/>
    <dbReference type="EnsemblBacteria" id="AQT68175">
        <property type="protein sequence ID" value="AQT68175"/>
        <property type="gene ID" value="STSP2_01330"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01330"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21543" checksum="6D588A392D954FCA" modified="2017-06-07" version="1">MTSWSYRNTRAFTLVEILAVVLVIGLIAAAAGTTGFKSFRKMQVKKAAGELYLAMKYARLTAVEKQTECRLLIDKEENSYAVVVGSSEDIEQLTSVSDLDNDAESVQVVSNQYTKPAELGDGIAFEKAEIASMYGDYQLQNGIVFRPDGSADAAVIQLGNGEYIYSINVMVATGKAKVIEGPAEEMTIGVVDLDEQGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK40</accession>
    <name>A0A1U9NK40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="4" type="ORF">STSP2_01450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01450"/>
    <dbReference type="EnsemblBacteria" id="AQT68292">
        <property type="protein sequence ID" value="AQT68292"/>
        <property type="gene ID" value="STSP2_01450"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01450"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27287" checksum="80C2E679290A891D" modified="2017-06-07" version="1">MDNAIEDARQLLDLLKKANRTVVLTGAGVSTASGIPDFRGPSGLYATVSQRVFEVDFLLSSPEEYYKIAYEYIHPLVDKEPNIAHRALAELEKAGLISAIITQNIDGLHQKAGSQDVIEFHGNVTTFRCVDCSRAFNRTRVDEMIVTDGVPMCQCGGLIRPDLVFFGDLIPEDAISRSQELATTCDVLLIMGTSLAVYPAASIPVLADQSGAKIVIVNKGPTELDHIADYRYEVGLEAFSQALMELIQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK41</accession>
    <name>A0A1U9NK41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA-modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01461"/>
    <dbReference type="EnsemblBacteria" id="AQT68303">
        <property type="protein sequence ID" value="AQT68303"/>
        <property type="gene ID" value="STSP2_01461"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01461"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34142" checksum="2D4C8366492C2A39" modified="2017-06-07" version="1">MGESKKYTFGPVPSRRLGLSLGVDLVPLKTCSQNCVYCQLGVHGEQTVERKPYVDIDVVLAELQQRIDGGLEADYITLSGSGEPTLHSQIGELIDRIHGMTDIPVALITNSTMLWDPAVRADCGKADVVLPSLDAGDGRTFEAMNRPEGSVTFTKLVDGLEKFCSEYKGKVWLEVFLCEGINTAPEEVARMKELVGKLDPDKVHLNTAVRPTADPQAKAVSAARLAAIAEEFGPKAEAVVDYAKLPARSDKDVDEGQVLEMLERRPCRIDDLCSSLGISIPRAINLLQRLLISEEVTAEARGLERWFRAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA4</accession>
    <name>A0A1U9NKA4_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68020">
        <property type="protein sequence ID" value="AQT68020"/>
        <property type="gene ID" value="STSP2_01174"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01174"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="334" mass="36774" checksum="05F91E78DE4EE71B" modified="2017-06-07" version="1">MRCDGLVFIASLFVCGWCVAVEGDGRAEKSDEKEEQVYRLSGSVDGPALSSTWEEWFEELEGAADKKELNAILFDGPGKGGPAVGATVRVVGRDVTREAVADEEGKFSFDELPRGYYKVYAEKVIENERTGKQVVARDESHSIDLNRGDRVVRLGLLKDNFITVRGWVRDTNGKTLAGVKVVGVTAPKYNGPTGETAEEERFIKKRYGQQVVKACSDEEGRFELAGFQGNGLRGILNYLVKANPEKCGYNFFVDILANRTGSAVQVKPKRVPLVSEESLYRARRIIGAANKVAERTGGEVLQEKEELPYLLPMIDGNVIEGVEVVMEVVDEQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL7</accession>
    <name>A0A1U9NKL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68482">
        <property type="protein sequence ID" value="AQT68482"/>
        <property type="gene ID" value="STSP2_01646"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01646"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8503" checksum="294808427DA8AF71" modified="2017-06-07" version="1">MLRKLDMNWWAWTSFVLLLIGGLNWGLVGLFGFDLVAAIFGELTMLARIVYIVVCLAAVLMIVDAAKSGHARTQPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM2</accession>
    <name>A0A1U9NKM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Propionate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">putP_1</name>
        <name evidence="8" type="ORF">STSP2_01442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68284">
        <property type="protein sequence ID" value="AQT68284"/>
        <property type="gene ID" value="STSP2_01442"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01442"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="527" mass="57874" checksum="EDA401B14BEFD648" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP9</accession>
    <name>A0A1U9NKP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68385">
        <property type="protein sequence ID" value="AQT68385"/>
        <property type="gene ID" value="STSP2_01545"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01545"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11924" checksum="95CA8994B6CDAB72" modified="2017-06-07" version="1">MGIENWSDNVVVLDLAAEPDLGEELESAVSLAQKKGDVNVVVDFTDVDIITSSSIAKLLKLRKVLTDTGRQLIFTGVGSQTMSVFKVTALDSVFEFVDDKFVALASLQMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL03</accession>
    <name>A0A1U9NL03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68408">
        <property type="protein sequence ID" value="AQT68408"/>
        <property type="gene ID" value="STSP2_01568"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01568"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14234" checksum="1A8DEB699878F654" modified="2017-06-07" version="1">MGLDDMLGDFSDDMTDGTMMGPGFGGANSRSSSQPQNLGQAHSRITHLETALAKTLTICEALWEIMRDENGYTDAMIQAKVRQIDNRDGKQDGRNKSAPIKCSNCGRTIAPRHQACMYCGNPNEKSLFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL59</accession>
    <name>A0A1U9NL59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68671">
        <property type="protein sequence ID" value="AQT68671"/>
        <property type="gene ID" value="STSP2_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01840"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31866" checksum="F130558EB6717462" modified="2017-06-07" version="1" precursor="true">MLRTILNVMLVVTLLGVVGCPPPVEVEEPLMECERDMTVGRLVEVLDAQRENAAALKARGRLSIRWVEEGKIKEETPDVQVRFVPESKLFLDGRILGQEVIRLGTNDEEFWLRMKPDEISMYQWGRWEDAAKCPGQQLLNPHNLLEALGMVRVDDGYDLTIRAGEYVLTEVDASGGFAKRVYVGCADYLVRKIEYYGEDGRVDVVIELEEYEEVGEGHFVPTRIGIINHGKNSSKAEFMLSSVGVYEDIKPKAFVRPEPEGIKNVYRLNENCEFVRQTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL65</accession>
    <name>A0A1U9NL65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68682">
        <property type="protein sequence ID" value="AQT68682"/>
        <property type="gene ID" value="STSP2_01852"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01852"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="41952" checksum="1B040ADB2CDF094D" modified="2017-06-07" version="1">MLSKERVLAAIERRPADRIPIYDSFWLDTVARWRQEGLSEVVSVQDYFGFDIHVMGIDASPRFKPELLETDGEMVTIRDRFGYVVKKEKNKSRTMMYLSHPAESQEQWESVKRGFNIDPDGPARVAKDPFPFKLEMGDSWQKVYEDYCDLLESGKYILGSAYGPHEAILRLHGFEKTLYSLCDSPGMLTDMAETYSNFLLQVINESLEKGVRFDGLFLVEDLAATNGMLFSPDQWRNIFKPSMAKIGEFLASNDLHFWMHCCGNAEPVFGDLIECGVQVLNPLEAKSGLDVCWLKDKYGEDLTFFGNIDAIKMSGTDEEIEEELQRKVTAAKQGGGYIYHSDHSVPPEVSWGRYKHIMEMVSKYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL78</accession>
    <name>A0A1U9NL78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ_1</name>
        <name evidence="1" type="ORF">STSP2_01725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01725"/>
    <dbReference type="EnsemblBacteria" id="AQT68557">
        <property type="protein sequence ID" value="AQT68557"/>
        <property type="gene ID" value="STSP2_01725"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01725"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17701" checksum="2D858958B789C1E4" modified="2017-06-07" version="1">MPELLFDISDIDLDNIEFGREQIAEVNPQSYEMEQLDAIVWYDKDSMRAIGYKDITENEFWVRGHIPGRPIMPGVIMIEAAAQLSSFYMKRIHGLEGFIGFSGIDKTKFRGTVVPGDRLYMLGHIHKVRSRQFSAMVQGVVNGKIVFDTVVSGMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL89</accession>
    <name>A0A1U9NL89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68701">
        <property type="protein sequence ID" value="AQT68701"/>
        <property type="gene ID" value="STSP2_01873"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01873"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="31753" checksum="21145D5193EB1C80" modified="2017-06-07" version="1" precursor="true">MNPAYHMTVEQAKSLLEINTNDLLIAEDAYKKLRRKLQNRLNMPGTTPEQREETIDKLSQIARAIDTIRQTAASQNSTSGASQQPPNFANSTPPQPKPFSSGNVQPTPTQSYYPHRSTPSSGWGQFVSFCQTAGFILHMLFKFIWVPTVFISQQLARLFAGISNSIRYSAVCNVLACISLISVSLAGVGSVVLMLAMKVPTAQVRVLAVPWCHVSVDGEELGVSGQAEPFYLREGEHVLELRTDTGQTLDKHITLSRHSETIIRANFQNETVTISGGHNNVNKSQNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI0</accession>
    <name>A0A1U9NLI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68598">
        <property type="protein sequence ID" value="AQT68598"/>
        <property type="gene ID" value="STSP2_01766"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01766"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041652">
        <property type="entry name" value="DUF5616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5616" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18872" checksum="2CC47D248310D3F2" modified="2017-06-07" version="1">MALQELTGRELVIDGYNVLIGIEAALSGGPIFIGRDSCYRDIASVHGSYRRVEETVHALHIIADAVQGLRVAGCRILLDSPVSNSGKLKTMMRELAEQNGWRWEIELLYNPDNEMIESDVPVATSDSDVLDRCSKWINLARYIIDRLAAESERVWLVDLSGDGGGVGGDGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR7</accession>
    <name>A0A1U9NLR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00392</name>
        <name evidence="3" type="ORF">STSP2_01063</name>
        <name evidence="4" type="ORF">STSP2_01730</name>
        <name evidence="5" type="ORF">STSP2_01824</name>
        <name evidence="6" type="ORF">STSP2_02022</name>
        <name evidence="7" type="ORF">STSP2_02025</name>
        <name evidence="8" type="ORF">STSP2_02289</name>
        <name evidence="9" type="ORF">STSP2_02731</name>
        <name evidence="10" type="ORF">STSP2_02984</name>
        <name evidence="11" type="ORF">STSP2_03019</name>
        <name evidence="12" type="ORF">STSP2_03244</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67249">
        <property type="protein sequence ID" value="AQT67249"/>
        <property type="gene ID" value="STSP2_00392"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67911">
        <property type="protein sequence ID" value="AQT67911"/>
        <property type="gene ID" value="STSP2_01063"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68562">
        <property type="protein sequence ID" value="AQT68562"/>
        <property type="gene ID" value="STSP2_01730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68655">
        <property type="protein sequence ID" value="AQT68655"/>
        <property type="gene ID" value="STSP2_01824"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68846">
        <property type="protein sequence ID" value="AQT68846"/>
        <property type="gene ID" value="STSP2_02022"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68849">
        <property type="protein sequence ID" value="AQT68849"/>
        <property type="gene ID" value="STSP2_02025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69102">
        <property type="protein sequence ID" value="AQT69102"/>
        <property type="gene ID" value="STSP2_02289"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69539">
        <property type="protein sequence ID" value="AQT69539"/>
        <property type="gene ID" value="STSP2_02731"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69787">
        <property type="protein sequence ID" value="AQT69787"/>
        <property type="gene ID" value="STSP2_02984"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69822">
        <property type="protein sequence ID" value="AQT69822"/>
        <property type="gene ID" value="STSP2_03019"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70042">
        <property type="protein sequence ID" value="AQT70042"/>
        <property type="gene ID" value="STSP2_03244"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00392"/>
    <dbReference type="KEGG" id="alus:STSP2_01063"/>
    <dbReference type="KEGG" id="alus:STSP2_01730"/>
    <dbReference type="KEGG" id="alus:STSP2_01824"/>
    <dbReference type="KEGG" id="alus:STSP2_02022"/>
    <dbReference type="KEGG" id="alus:STSP2_02025"/>
    <dbReference type="KEGG" id="alus:STSP2_02289"/>
    <dbReference type="KEGG" id="alus:STSP2_02731"/>
    <dbReference type="KEGG" id="alus:STSP2_02984"/>
    <dbReference type="KEGG" id="alus:STSP2_03019"/>
    <dbReference type="KEGG" id="alus:STSP2_03244"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10420" checksum="6777687CF29FD9DB" modified="2017-06-07" version="1">MKRKNHSPEQIVKMLRQADAVIGSGGTVQQACRELGISEATYYNWRKQYGRMKLDQVKQLKALQKENAQLKKLVADQALDNAILKEALSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV7</accession>
    <name>A0A1U9NLV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01886"/>
    <dbReference type="EnsemblBacteria" id="AQT68714">
        <property type="protein sequence ID" value="AQT68714"/>
        <property type="gene ID" value="STSP2_01886"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01886"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32739" checksum="556ADAF1E462D97D" modified="2017-06-07" version="1">MSNPIENRYEFVYLFDVENGNPNGDPDAGNMPRIDPETSYGIVTDVCLKRKIRNFVEIAHDDKAPNCIYVKERAILASQQAKAYEALKLKNDKKNGDGIAQARRWMCQNFYDVRTFGAVMSLQNYNCGQVRGPVQINFGRSIDAIAPRDLSITRMAVATEKEAKSQGGDNRTMGRKSIVPYALYRTEGYVSACLAEKTGFGEDDLELLWNSLVNMFDHDRSAARGKMCPRKLIVFKHDSKLGNAPAHKLFETVDVKPCEGNPPRGWDDYEDGLSCPPSGSLDGFNGVEVMHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW1</accession>
    <name>A0A1U9NLW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">STSP2_01738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01738"/>
    <dbReference type="EnsemblBacteria" id="AQT68570">
        <property type="protein sequence ID" value="AQT68570"/>
        <property type="gene ID" value="STSP2_01738"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01738"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="477" mass="52409" checksum="D17BFE869D55AC4D" modified="2017-06-07" version="1">MSEIKEECGVFGIFDDAEAVKKTYFGLHSLQHRGQESAGIASSDGEYIKCYTGMGQVGRVFRPSKGFLEKLENPTAIGHLRYSTTGSSNPLNAQPFLSEYSQGQIAVAHNGNLINANLLRDEYEAYGHIFKSSNDTEVVVHLLAKPTHVSKPDPLAHVLNHLHGAFSILFLFPDRIEAARDPFGFRPLCLGKTKAGKYCVASETCAFDAIEAEYIRDVEPGEIVTIDKTGLSSRFFVEPGTVTPGHCIFEHVYFAKQSSRIFGDSVHEFRKQSGRVLAQEHPVDADIVTPVPDSGTSAAVGYASESGIPFDMGFVRSHYVGRTFLAPSQELRDLAVKMKLAVVKEAVAGKRVVVVDDSVVRGTTTKGKINSLREAGAKEIHMRVACPPLVSPCYFGVDFPTKEELIANNRTLEEIRDFLKVDSLGYISLDGLLSCASLPGDHYCTACWSGDYKMPVNTAFNKLSLERHQMQLFDNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW3</accession>
    <name>A0A1U9NLW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68724">
        <property type="protein sequence ID" value="AQT68724"/>
        <property type="gene ID" value="STSP2_01896"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01896"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8615" checksum="8E3919AC2AC61CC4" modified="2017-06-07" version="1">MRILYVNNSGGGFADYIDISENTTVEQFFNKKMPADSPEDYLIRVNRQPVPRDYILQPNDRITITPTKVQGARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW7</accession>
    <name>A0A1U9NLW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68728">
        <property type="protein sequence ID" value="AQT68728"/>
        <property type="gene ID" value="STSP2_01900"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01900"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7998" checksum="C05CEEA4F0300F15" modified="2017-06-07" version="1">MSRLEQIVNSYPIQRIIVPNRRLLDGEIVTVDGEDFVYDGRTGKLRNIRNLQETLRPDELRETPSGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM49</accession>
    <name>A0A1U9NM49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7-keto-8-amino-pelargonic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bioF</name>
        <name evidence="11" type="ORF">STSP2_02201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02201"/>
    <dbReference type="EnsemblBacteria" id="AQT69022">
        <property type="protein sequence ID" value="AQT69022"/>
        <property type="gene ID" value="STSP2_02201"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02201"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="42"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="391" mass="42899" checksum="C54347EBA45DE646" modified="2017-06-07" version="1">MERFEYLQNQLKDLRLRSRFRQLRPLVNSAAAVAQIAETGQRVVNFSSNNYLSIADHDKIKKEVQQAVSDFGYGSGGSRLICGTSPTHVGIEREFADFLGFEAALLFSSGWAANQAVLKTIPQKGDLVLLDKLDHASIIDGCLAGEADFRTYRKNRLDRLEKLLTESNHQRKFIVTESVFSMDGELAPLEELIRLRDRYNAYLIVDEAHSIGCLGRCGAGLAEQTGVLDKIDILISPLGKAFAASGAIVAGSRPVVDYLVNGARSFIYSTACSPVNCAAILAALEVVRTEPQRRQSLCELASYARSELQKTGFEIGRSETYIIPVILGRDETALKAAAKLLEDGYFVVAIRPPTVPPGSARLRISLQADHTKAQIDGLIESLVAFRTDNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA7</accession>
    <name>A0A1U9NMA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02142"/>
    <dbReference type="EnsemblBacteria" id="AQT68965">
        <property type="protein sequence ID" value="AQT68965"/>
        <property type="gene ID" value="STSP2_02142"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02142"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="349"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="696" mass="72369" checksum="271C2327A20E6310" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH5</accession>
    <name>A0A1U9NMH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcK_1</name>
        <name evidence="5" type="ORF">STSP2_02175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02175"/>
    <dbReference type="EnsemblBacteria" id="AQT68997">
        <property type="protein sequence ID" value="AQT68997"/>
        <property type="gene ID" value="STSP2_02175"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02175"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34292" checksum="090D6C3810A59FD0" modified="2017-06-07" version="1">MAEIFVGIDLGGTNIKIGCFDSNLNLLTETSVPTLVENGASDIVDRIGQTVESLLGQYGLALSEIAAAGIGTPGVVDVENGIVLNAPNLKFNDTPLRQMIRDRLGCPVVLENDANVTCWGEHVAGAGKGAQDMILITLGTGVGGGIISNGELVHGYANAGAEIGHMIVQPGGRLCGCGQKGCVEAYSSASSTARRAIEALQENAEDSTLQQVLKENGTVTCEDVYDHLAKGDDLARQITDTTAEYLALLCVSLLHVAGPERILFYGGMIAAGDLLLEPIKKYFRQHIWTLQHEEIELCFAELGTHAGIIGNAALATHRLEKGQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP1</accession>
    <name>A0A1U9NMP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">STSP2_02182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02182"/>
    <dbReference type="EnsemblBacteria" id="AQT69004">
        <property type="protein sequence ID" value="AQT69004"/>
        <property type="gene ID" value="STSP2_02182"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02182"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="383" mass="42640" checksum="B0DB62545B8D9609" modified="2017-06-07" version="1">MRLYRSQRFIRPDLECHISSKALKHNVRNLKSLCKDGTKYCAVVKANAYGHGIAEVVNILKTEDVDFFAVNSFYEALHIDTLIDRQSILIFEAVYPSQPREQILISAERGFHCPVASADAVNFIQDVLEGSSHVFNAHLNIETGMSRCGLDQNEAQTLIDLIDQAPNVRLAGIYTHFATADEVELDYAYEQLRRFEDFLGTASIRKRKDVIIHASNSAATIKMPEANFDMVRCGISMYGYYSRPMTDPPIKLSPTMKLQAPIARLKHIPAGHSVSYGRSFVPYRDTVAAIVPLGYADGYWRCFSNKAPMMVGEHVGKVIGRVCMDQLLLDVTDVPGVAVGQMVTIIDDKHDSPCGGYALADLAETICYEILTSVHAHVSRIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR3</accession>
    <name>A0A1U9NMR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69203">
        <property type="protein sequence ID" value="AQT69203"/>
        <property type="gene ID" value="STSP2_02390"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02390"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8709" checksum="E9E0B4B8947AD2D4" modified="2017-06-07" version="1">MSDLHTVSQIADLFGEPPQRVAYIIRKYRIKPRQRVGITRLFDEAQLPVIKQGLYGIRIHRDRGLAAPAEREVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS9</accession>
    <name>A0A1U9NMS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-xylosidase</fullName>
            <ecNumber evidence="6">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yicI_1</name>
        <name evidence="6" type="ORF">STSP2_02397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02397"/>
    <dbReference type="EnsemblBacteria" id="AQT69209">
        <property type="protein sequence ID" value="AQT69209"/>
        <property type="gene ID" value="STSP2_02397"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02397"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640377" evidence="3">
        <location>
            <begin position="27"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="848"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="940" mass="104749" checksum="673D0DB2119D6429" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT8</accession>
    <name>A0A1U9NMT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pheS</name>
        <name evidence="15" type="ORF">STSP2_02239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02239"/>
    <dbReference type="EnsemblBacteria" id="AQT69054">
        <property type="protein sequence ID" value="AQT69054"/>
        <property type="gene ID" value="STSP2_02239"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02239"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="107"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="37541" checksum="07D488CFA739C520" modified="2017-06-07" version="1">MLDKFQQIGDKARQALKNISNSEELEQFRIKYLGRKGDITGMLSQIGKLAPEQRKEGGQLANKIKKEITASFEELKKTLGTTTKKAGPQIDVTLPGIPVERGKQHVITQTITSLLEIFGRMGFDVAYGPEVEDEWHNFIGLNIPPDHPARAPEDNFYVDDQRLLRSQTSTIQIRVMEKEKPPIRIVAPGRVYRPDTVDATHMYMFHQIEALVVDEGITMVDLKTSVDQFIHAFFGANTKWRFRPSFFPFTEPSCEIDLLWVDKNGNEEWMEVGGCGMVDPNVFDAVGIDSEKYTGWAFGFGIERLAMRKYGITDIRLLFENDLRFLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV0</accession>
    <name>A0A1U9NMV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69064">
        <property type="protein sequence ID" value="AQT69064"/>
        <property type="gene ID" value="STSP2_02249"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02249"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11330" checksum="757EAADB8442CA6F" modified="2017-06-07" version="1">MDVLKALYEFFPTAVYTGKCLVFVSDEWRVELTKHTNTDYSNINCSLPMVRVKIYKKALNGEFAPGHYEDFQLDSVGELANQIERYIQFAIGGSLRENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN06</accession>
    <name>A0A1U9NN06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CzcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">czcA</name>
        <name evidence="4" type="ORF">STSP2_02311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69124">
        <property type="protein sequence ID" value="AQT69124"/>
        <property type="gene ID" value="STSP2_02311"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02311"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </evidence>
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    <sequence length="881" mass="98425" checksum="87823C8B7AFFA553" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        </source>
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            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
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</entry>
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    <accession>A0A1U9NNE6</accession>
    <name>A0A1U9NNE6_9BACT</name>
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        </recommendedName>
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    <gene>
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        <name evidence="9" type="synonym">xylA</name>
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
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    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
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        <property type="protein sequence ID" value="AQT69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02327"/>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02327"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="437" mass="49180" checksum="E7A106798799D73B" modified="2017-06-07" version="1">MNEFFPEVTKIDYQGSDSKDPLSFKHYNPNEKVLGKTMAEHLRFAVCYWHTFKGLGDDPFGGPSIIRNYNASNDPMQVAKDTMHAAFEFFTKLGVNFWCFHDRDIAPEADNLAETNKKLDEMVALAKKLQDDTGVKLLWGTTNAFSHRRFTAGASTNPSPAIFAYAASQVKKAMEITHELGGQGYVFWGGREGYSTLLNTDMKRELDHMGLFMNLAVDHKKKIGFQGDLFIEPKPKEPTKHQYDFDAGNCVAFLQKYGLTDHFKLNIEANHATLAGHTFQHELEYAVANDMLGSVDANRGDMLLGWDTDQFATNLYDSTLAMYTIIKGGGFTSGGLNFDAKLRRESVDPIDLFHAHIGAMDCFARGLKIAEKMIADGRLEQKLKQRYSGWDSGFGAETEAGKVDFEKLEQYTIENGEPELRSGRQEMLENILNEYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF7</accession>
    <name>A0A1U9NNF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lacZ_5</name>
        <name evidence="5" type="ORF">STSP2_02337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69150">
        <property type="protein sequence ID" value="AQT69150"/>
        <property type="gene ID" value="STSP2_02337"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02337"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956681" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122087" checksum="099F76CA298DB250" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG7</accession>
    <name>A0A1U9NNG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c551/c552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69278">
        <property type="protein sequence ID" value="AQT69278"/>
        <property type="gene ID" value="STSP2_02467"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02467"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120704" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="906"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1047" mass="111956" checksum="B544682362FCBD65" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK1</accession>
    <name>A0A1U9NNK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation efflux system protein CzcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">czcC_2</name>
        <name evidence="2" type="ORF">STSP2_02674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69483">
        <property type="protein sequence ID" value="AQT69483"/>
        <property type="gene ID" value="STSP2_02674"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02674"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48862" checksum="626C992D8F27E49B" modified="2017-06-07" version="1" precursor="true">MKSSLNRTVWVFIVVVLVLSKVGVSGQKQGESEQKTVKVSTLRDYLRYAALHNAELKGAFQEFRAAVEQVPQSEALPDPQFKYTYFIEEVETRVGPQKQRVGISQTFPWFGVIEARTDAAAMAAKAAKERYEAVKLELFNKVKQAFYEYAYLFNAIEIAEQNLELLEHFEEVARIRYKAAAAEHPDIIRAQVEYAKLADELESLRELRRPILAKLNALLNRPEDAALPWPERAEYEPEAVQEEKMLAFLQEKNPELTAQRFGVEVARQRVVLARKRSYPDVTAGIEWIDVGSAVNSGVSDSGQDALMATVSFNLPIWGKNNRARERQATANMLKAKSQVVELQNDLIARASKTVYLVQDGNRKVELYEDILVPKATEMVSASETAYMSGKVDFLSLVDAQRQLLEFQLKLERAITDSLQSLAELEALTGGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR8</accession>
    <name>A0A1U9NNR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02754"/>
    <dbReference type="EnsemblBacteria" id="AQT69561">
        <property type="protein sequence ID" value="AQT69561"/>
        <property type="gene ID" value="STSP2_02754"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02754"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="30118" checksum="4433BED66AEC192C" modified="2017-06-07" version="1">MRRRAFTLIELLVVIAIIALLLAIMMPALSSVKRRARRVVCGAHMKNISLVLNLYASDHNSKLPVVPQQGPYLGRWLFDLPRNVADDIRTDYQLESIYCPANTLRSKENKELEDYFVSHMSVNDIDDVDETTTGWAVTDYFWLLTFNADWREADVRNTSYNTIYPDDSRLAGRRIFIDKTSVPNASSRPMVVDLVFTHDADEPRDFSEIYGGRPEPFSSNHLDGSKAEGGNVLNADGSVEWRNLREMDKNYVAPNNNGAVQHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY4</accession>
    <name>A0A1U9NNY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multidrug transporter MdtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mdtA_1</name>
        <name evidence="4" type="ORF">STSP2_02618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69428">
        <property type="protein sequence ID" value="AQT69428"/>
        <property type="gene ID" value="STSP2_02618"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02618"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="94"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="43597" checksum="0F9A46B7590B5888" modified="2017-06-07" version="1">MTEQLSGRQTDGGNTEVLVHRHYKPIVKVMLKKTQTANCMLIASSLILLCLSAGCNHQEPEEIVRPVQWARVEARTSGFTRTFSGVSQASVRSELSFRVGGTIERIAVDEGDPVSSGQILAELEKEDFRLKIKEAEAALAKAKAQARNAQANYTRAKRLYEQNNISLNELDVARAEAESAQANVDVAQTALRLAERRFEYTTMKANREGWVTRIHAEENENISSGQPVMTLVSGEKMEVQIGIPEDLIGSVKKGQQAAVEFEAWPEREYEGEVTEVGVTVGRTATTFPVAVTLKKSDTKVRLGMAADVTLYFAGKRTAFLVPAIAVGEDINGKFVYVLEEKNNGYAIATRRKVITGRLTEEGLEVLSGLERGERIITHGVTRISDGEKVRMLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY8</accession>
    <name>A0A1U9NNY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02698"/>
    <dbReference type="EnsemblBacteria" id="AQT69507">
        <property type="protein sequence ID" value="AQT69507"/>
        <property type="gene ID" value="STSP2_02698"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02698"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36273" checksum="65A0D027E2F57081" modified="2017-06-07" version="1">MAKNKNKEVSCIYVICGKDAHLVGKQCESLVDSLLGDDERDMALFQPDPDKVDCVTVLDELRTVPFLASRRVVVLRGADKFITANRPLLERYFEEPSKSGVLVLVVSKWQKSTKLAKKLPKVGELIEVGDLKPAQLPGYAVERAKTEHSKTLDRDAAAALVEFVGDDPGKLASEVDKLAMYVDESAKISLDDVETLIGKSRAFNAFEVIDLITSGNTAGAVERLRNMFVHDPSAEYTAVGAFAYHMRKMFNAKVMIETGVPIRQVCGKLRIFGKNQSAFLTQIKKVGLAQLGSAIRELAHIDLSMKTGGMDGKVAIEQLVFKLGMTLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ3</accession>
    <name>A0A1U9NNZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoteichoic acid synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ltaS1</name>
        <name evidence="3" type="ORF">STSP2_02813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02813"/>
    <dbReference type="EnsemblBacteria" id="AQT69619">
        <property type="protein sequence ID" value="AQT69619"/>
        <property type="gene ID" value="STSP2_02813"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02813"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="670" mass="74730" checksum="2D9D2AE17D12F15C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP09</accession>
    <name>A0A1U9NP09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhdE</name>
        <name evidence="3" type="ORF">STSP2_02845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02845"/>
    <dbReference type="EnsemblBacteria" id="AQT69651">
        <property type="protein sequence ID" value="AQT69651"/>
        <property type="gene ID" value="STSP2_02845"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02845"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21206" checksum="930735A2CAD18107" modified="2017-06-07" version="1">MNKSSDFILASASPRRKKLLREAGYSFDIIPSQVDESAFPTEGIASDEHTMLLAAAKARNVANTHPDRLVLGADTIVDLNGQIIGKPRDAAHAEQITRDLFSEPHKVITGLALVRLSDNLEIIRHAVTTVYPRKLTEQQIADHIAAGDWQGKAGAYGIQETGDEFVERIEGSFTNVIGLPLELVKELLDPLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP39</accession>
    <name>A0A1U9NP39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69669">
        <property type="protein sequence ID" value="AQT69669"/>
        <property type="gene ID" value="STSP2_02863"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02863"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="36428" checksum="2A12AECFC7205C35" modified="2017-06-07" version="1">MIKRNTVLVLGAGASMPYGFPSGGRLKAEILNDLNNDREPFIRHSFPEGLVIEFYKRFARSGQSSIDAWLGRSGHEDYLEIGKWAIAKRLLGYEKTTALFDKINLSYLKTVQQSWYHKLYNALDAPFDEFDQNQLSVVTFNYDRSFEHFLHTALKNDNCGRSGDEVAEKARSIEVVHVHGQLGYLPWQNRGGVVPFDSEAEQKHINEAAKHIKIIHEASDEDGEFERARALLIEAEMAIILGFGFHPENLTRLGLKNLKDRRSKEGKRNLTIWGTSLGLANQDKHVGHEHFHKLLPRLDDRFKNKTVYQLLHDHVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP50</accession>
    <name>A0A1U9NP50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">mutL</name>
        <name evidence="8" type="ORF">STSP2_02918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02918"/>
    <dbReference type="EnsemblBacteria" id="AQT69722">
        <property type="protein sequence ID" value="AQT69722"/>
        <property type="gene ID" value="STSP2_02918"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02918"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="446"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="635" mass="70988" checksum="FE150FB5D39DC1F1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP53</accession>
    <name>A0A1U9NP53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cph1_8</name>
        <name evidence="6" type="ORF">STSP2_02888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69693">
        <property type="protein sequence ID" value="AQT69693"/>
        <property type="gene ID" value="STSP2_02888"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02888"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="444"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="513"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="746" mass="84224" checksum="FAD71FEE425D2956" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP54</accession>
    <name>A0A1U9NP54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">STSP2_02770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02770"/>
    <dbReference type="EnsemblBacteria" id="AQT69577">
        <property type="protein sequence ID" value="AQT69577"/>
        <property type="gene ID" value="STSP2_02770"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02770"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="214"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="333"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="440" mass="48824" checksum="8265E9F7C65B4A3B" modified="2017-06-07" version="1">METLKDKFKVQKERAILVAAAQRGESGYKYNDLSELSALAESAGAAIVYKLQQKIDRINPSTYIGRGKAELLGEHAESEKADVVIFDNDLSPAQIRELEKVVGVRVIDRSELILDIFATRARTRQAKLQVELAQLQYTYPRLTRLWSHLDTVAGAAGGAGAAGAVGGIGTRGTGEKQLEIDRRLVNKRITELKREIEGIDKRKMREIKGRHDQYKVSLVGYTNAGKSTLMNALTDAEVFVEDRLFATLDTRTRKWSVDKGVEVLLSDTVGFVSHLPHHLVASFKATLEEAVHADLLLQVVDVSDEDVFEQIKSVDQVLDDIGCGEKERLVLFNKSDALASEANLESLQAIYPDAICISARTGMNLDLLAQAVLDRYRQEEMTVRVKIALSDGKTQSFLRGYCEILEENYTDSHVEIEARLGKSQLPALKSLKPAELRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP69</accession>
    <name>A0A1U9NP69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pullulanase secretion envelope PulD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pulD</name>
        <name evidence="6" type="ORF">STSP2_02829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02829"/>
    <dbReference type="EnsemblBacteria" id="AQT69635">
        <property type="protein sequence ID" value="AQT69635"/>
        <property type="gene ID" value="STSP2_02829"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02829"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Secretin_N" evidence="5">
        <location>
            <begin position="560"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="5">
        <location>
            <begin position="671"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="5">
        <location>
            <begin position="784"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="375"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="587"/>
            <end position="629"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="736"/>
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            <end position="1060"/>
        </location>
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            <begin position="1151"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1174" mass="129906" checksum="000947D2D544D377" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD8</accession>
    <name>A0A1U9NPD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02798"/>
    <dbReference type="EnsemblBacteria" id="AQT69604">
        <property type="protein sequence ID" value="AQT69604"/>
        <property type="gene ID" value="STSP2_02798"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02798"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="20358" checksum="EA34DAB6451178BA" modified="2017-06-07" version="1">MGRDLRRRLFRLGKKRGPQIGKTKRGKGTKWMVVVDGQGVPLGAHLDSASPSEIKLLEPTIEKIAVPRRGRGRPRKNPTRIVADKGYDSDPLRERLARRNIELICPYRKNNKQKKYHDGRKMRRYKRRWTVERTFAWLGNFRRLVVRYEREIKMYQAFFHIACLIITLRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI2</accession>
    <name>A0A1U9NPI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hup</name>
        <name evidence="2" type="ORF">STSP2_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02605"/>
    <dbReference type="EnsemblBacteria" id="AQT69416">
        <property type="protein sequence ID" value="AQT69416"/>
        <property type="gene ID" value="STSP2_02605"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02605"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11886" checksum="4AE256AB150A1E6C" modified="2017-06-07" version="1">MATVTKKELIDRIADQTQAKRVVVKRIIQSFLDEMVTELSDDNRLEFRDFGVFETRTRAARVAQNPKTLERVQVPAKRTVKFKMGRLMREKLSTPVEMSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL3</accession>
    <name>A0A1U9NPL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplJ</name>
        <name evidence="6" type="ORF">STSP2_03059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03059"/>
    <dbReference type="EnsemblBacteria" id="AQT69861">
        <property type="protein sequence ID" value="AQT69861"/>
        <property type="gene ID" value="STSP2_03059"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03059"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19024" checksum="269DC17177D8522D" modified="2017-06-07" version="1">MSKYVKNLLQAELERKFSDVDNFVVVETKGLSGNENNEMRGELRDKDIRLSVVRNAMMRRAMENLDKPNGIGLFEAGPCTVAYGGDSVVDVAKALEDWTKKYDFVNFKGAYVDGEALSSEDAKALAKMPNRAELQGEIVQIAQTPGSNIAGAVTGPAQHLAGCIKSLIEKLEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ3</accession>
    <name>A0A1U9NPQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding transcriptional activator PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_03089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03089"/>
    <dbReference type="EnsemblBacteria" id="AQT69889">
        <property type="protein sequence ID" value="AQT69889"/>
        <property type="gene ID" value="STSP2_03089"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03089"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8181" checksum="4ACFF30EBA6E9E3C" modified="2017-06-07" version="1">MRKLYLSRTDRKVLGVCGGIGETYDIDPTLVRLIVVFAAIITGFIPVAIMYIVAWAIIPDEPKSDEGGVESSEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ8</accession>
    <name>A0A1U9NPQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/EbsC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03111"/>
    <dbReference type="EnsemblBacteria" id="AQT69911">
        <property type="protein sequence ID" value="AQT69911"/>
        <property type="gene ID" value="STSP2_03111"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03111"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17343" checksum="A37B07A2A1D80170" modified="2017-06-07" version="1">MQLMDYLDKIHAKYEVKQHRPTFTAQEMAAEEHVPGIHVAKPVVIKADESYYMCVLPASYKIDFDMLKRQLGAESLELAEEGEMAKMFGDCALGAEPPFGNLYGLTTFVDETLAEEDYIVFQGGTHENAIRMEMSEYKRLAKPTVMSFSYPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS9</accession>
    <name>A0A1U9NPS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69942">
        <property type="protein sequence ID" value="AQT69942"/>
        <property type="gene ID" value="STSP2_03142"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03142"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="616" mass="65318" checksum="39DB9EDC827044F2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU3</accession>
    <name>A0A1U9NPU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriophage tail assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03151"/>
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    <dbReference type="KEGG" id="alus:STSP2_03151"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="Pfam" id="PF05876">
        <property type="entry name" value="Terminase_GpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="640" mass="72661" checksum="303F30B201A2CB32" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ88</accession>
    <name>A0A1U9NQ88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpoE</name>
        <name evidence="4" type="ORF">STSP2_02977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_02977"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02977"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="652" mass="73989" checksum="8C169B5625939AFE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD4</accession>
    <name>A0A1U9NQD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_03347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70143">
        <property type="protein sequence ID" value="AQT70143"/>
        <property type="gene ID" value="STSP2_03347"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03347"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19156" checksum="86200686E3FBCBBF" modified="2017-06-07" version="1">MLKGLHAAKGIQLVIGLITGIVFGFLLQKGGVTEYNILIGQLLLEDFTVAKVILMAIAVGMPGIFVLEKLGLVRLHIKKGSVGASLIGGIIFGVGFGLLGYCPGTVTGAAGQGSLDALLGGIPGQMLGAGLFAWWFSTLDAKILNKGDFGKLTIPDLLKVNRLVIVIAMEIAIIVSLVLLEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH6</accession>
    <name>A0A1U9NQH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tsf</name>
        <name evidence="7" type="ORF">STSP2_03386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03386"/>
    <dbReference type="EnsemblBacteria" id="AQT70181">
        <property type="protein sequence ID" value="AQT70181"/>
        <property type="gene ID" value="STSP2_03386"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03386"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="6">
        <location>
            <begin position="77"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30945" checksum="54C4F3114340D2AF" modified="2017-06-07" version="1">MAEISASQVMKLRKMSGQGMMDCKKALKEADGDLDKALEELRKKGLKTMAKRAGRETSEGIVLTQASDDGKTVAMGTLCCETDFVAKSEDFKSLAEKMSSVLLTVDGVEGAETIVESEVDGKKFSELITECVSKTGEKTEVVDFIRISLEKPGTIGTYTHFNNKIGAMVVVETSNDETAKAVEDVARDAAMHVSAINPVAVDRDSIDAETIERERAAAAEEVQNKPANIIDKIVDGKMNKFFKENCLVDQPFVKDDSKTVSEAVSEAAKAAGGEAKITRFIRFEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM4</accession>
    <name>A0A1U9NQM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1,4-beta-xylanase B</fullName>
            <ecNumber evidence="2">3.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xynB</name>
        <name evidence="2" type="ORF">STSP2_03438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70232">
        <property type="protein sequence ID" value="AQT70232"/>
        <property type="gene ID" value="STSP2_03438"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03438"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="CBM6" evidence="1">
        <location>
            <begin position="707"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="830" mass="93682" checksum="91411F8D131841B0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT1</accession>
    <name>A0A1U9NQT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically-inducible protein Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">osmY</name>
        <name evidence="2" type="ORF">STSP2_03341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03341"/>
    <dbReference type="EnsemblBacteria" id="AQT70137">
        <property type="protein sequence ID" value="AQT70137"/>
        <property type="gene ID" value="STSP2_03341"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03341"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="260"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="500" mass="55271" checksum="F8C3121EBB54AD01" modified="2017-06-07" version="1">MNLKNRNLFSAYGFLVSVLIISFLGSVSCGAVIKSDSDINDAIMRQMEKDDVVSPHLVDIRVNEGIVTLDGSVDNLIAKERALNIAGSILGVVEVRDELVVRPIEIPDQAIRQNVKQALEDNPVTELMALDVKVENGVVSVGGEVKSITEKRIAEKIAESIAGVRSVRNEIEVSVKIDRPDSELAAEIRQNMKYDPYLNAQSIDVAVKDGVAVLSGETGSVFQMGRARRNAFILGVKRVDSSDLIVKPWKEYPTEMQDSTAVNVEAAVASALSSDVRVNRENIRIDIRGHKATLRGTVASLYEKNAAEDDASNVTGVWQVSNKLKVRPQEVPSDDAIAGKIRVALKRHTVTEPHEITVTVRNQKVYLYGNVQNITEKNMAENIASQIKGVAAIDNRISVVDAEDAEYLWKSDQQIKEDIRDELFWTVFVEAEDVNVMVQDGTAILTGTVNDWQEVLAAIENAYEGGAEKVKSDLDVRNNEDEQLPPASRDMHPYYYFGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY9</accession>
    <name>A0A1U9NQY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsmG</name>
        <name evidence="3" type="ORF">STSP2_03412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03412"/>
    <dbReference type="EnsemblBacteria" id="AQT70207">
        <property type="protein sequence ID" value="AQT70207"/>
        <property type="gene ID" value="STSP2_03412"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03412"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="26761" checksum="469B54F135CA04DB" modified="2017-06-07" version="1">MTTHKFQYTGLNEDQLTKFNQLADLLVDQNRVHNLTTITAAEDIYARHFVDSLAALELLDELKPEQSEPPRLLDIGSGAGFPALPLAIALPDWDITSLEATGKKVRFQEHARNSLNLTNFTARQGRAEILAREDTYRENFDVVTARALAELRVLAELTIPFVRVGGHFLAWKGPDPAEEVDSARQAIQLLGGRVRKFYDYQLAQNRKFTIVVIKKVTMTPAEYPREFKNIKKSPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR09</accession>
    <name>A0A1U9NR09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor YlaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ylaC_3</name>
        <name evidence="4" type="ORF">STSP2_03389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70184">
        <property type="protein sequence ID" value="AQT70184"/>
        <property type="gene ID" value="STSP2_03389"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03389"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="194" mass="22741" checksum="B772378EC69E5F19" modified="2017-06-07" version="1">MLSNADIKLTREMTGSDMNACVQLACREPSALAHLYDRYYDRIFRFCVYRVGSRTVAEDICSAVWVSVAKSIKHFQGDGETDFRKWIYTIAVNEVNSYYRKTARRNRHLRLLAENADDEQLSEDSTYPQWRQVQKALKSLKTRQQSIIMLRFFEKMSFDEIAEIVGVRASTVRVTLHRSLKKLQKKLESQMEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR52</accession>
    <name>A0A1U9NR52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">STSP2_03430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03430"/>
    <dbReference type="EnsemblBacteria" id="AQT70224">
        <property type="protein sequence ID" value="AQT70224"/>
        <property type="gene ID" value="STSP2_03430"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03430"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25604" checksum="C7EBFDCCBA3F96D0" modified="2017-06-07" version="1">MYILPAIDLMDGKCVRLIQGDYHKQMVYRDNPVDQAAEFRQAGAQWLHVVDLDGAKIGKSVNADTIAAIVNADLGLKVEVGGGIRDEDSIKRMLNAGVDRVIIGTRAVNDFGWFTQMVEKYPNKLVLGLDARGSKVAIEGWTQEGSHSLLEFAKQAAHMPIAAIIYTDISKDGMMAGPNFERTGELAAAVSVPVIASGGVTTLEDIKKLAPLQVEGAIVGRALYEGTLDLKDAIAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR94</accession>
    <name>A0A1U9NR94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03248"/>
    <dbReference type="EnsemblBacteria" id="AQT70046">
        <property type="protein sequence ID" value="AQT70046"/>
        <property type="gene ID" value="STSP2_03248"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03248"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="708" mass="77791" checksum="63391A0BAD8E5DCB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRF6</accession>
    <name>A0A1U9NRF6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03520"/>
    <dbReference type="EnsemblBacteria" id="AQT70314">
        <property type="protein sequence ID" value="AQT70314"/>
        <property type="gene ID" value="STSP2_03520"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03520"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17227" checksum="0BE30F3EF4F3331B" modified="2017-06-07" version="1">MDTLKDFLKPEIIWCLVGLVLLLMEFAVPGLILFFFAIGAWIVALVCLFWDSAGLDAQLIIFLIASITSLLALRRYLKNIFHGHIRSVQSGKQDLDEFVGQRVTVRSAIPANGTGRVEFRGTEWNATSDDPLAPGEPAEIISKDNLTLKVKKLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS25</accession>
    <name>A0A1U9NS25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modulator of FtsH protease HflK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflK_2</name>
        <name evidence="5" type="ORF">STSP2_03522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03522"/>
    <dbReference type="EnsemblBacteria" id="AQT70316">
        <property type="protein sequence ID" value="AQT70316"/>
        <property type="gene ID" value="STSP2_03522"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03522"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="Band_7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34648" checksum="601E14C0751B7902" modified="2017-06-07" version="1">MLSAVIGPVAVILIVVIVIAAIAFFKTIRIVPQKSAYIIESLGKYSKTLEAGFHILVPFIDKVAYKHTLKEQAVDVPPQTCITRDNIAVEVDGILYMQVVDAKRASYGIDNYLFAASQLAQTTMRSVIGKLDLDKTFEERDNINSVIVEAVDKASDPWGVKVTRYEVKNIVPPQSIKDAMEKQMRAEREKRAMIAESEGERQSRINRAEGEKQQLIAQSEGEKQKRINEAEGRAAEIEKVAEATSLGIKRIAAAIIEEGGSQAVDLRIAEQYLDEFGKLAKTNNSMIIPTDLSDIASVIKSAKMALSQQKTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG08</accession>
    <name>A0A1U9NG08_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaA_1</name>
        <name evidence="8" type="synonym">dnaA</name>
        <name evidence="13" type="ORF">STSP2_00001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00001"/>
    <dbReference type="EnsemblBacteria" id="AQT66863">
        <property type="protein sequence ID" value="AQT66863"/>
        <property type="gene ID" value="STSP2_00001"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00001"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="153"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="364"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT66863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="52153" checksum="3C001E5ADAB0AE18" modified="2017-06-07" version="1">MHTTLMDDVTAIDKAISKRIGVGKHKVWFKNSTQFSVADGYLTIGVPNHFIGSWIENHFMDDIQDAIREVTGDEKKITFNVDASLSGTQKKPVLDSQAKSVRKAREVNTRRRVKPKAVKVKPLKLSLDTFIAGPGNELAFNAARAVVSESKTLFNPLFLHGGYGVGKTHLLQGICNEISKQRPGARWIYVSAEEFANEFVIALKTQKLDAFRRRFRQADVLAIDDIHFLASKPSMQEEFLHTFNTIDLAGKQIVLASDAHPKMIGQLCEKLVSRFVSGMVVKMESPDFETRCSICRQRAAEMKKHVPDEVIEHIAGSMHTNVRELEGALLKLVAFASIGNGQITLRMAEQVLAEHISRTDPIVHISDIDSATATYFGITPADIHSSKKDRTVSTARSFSMYLARKYTKMSYPEIGKLMGGKNHATVILACRKVEKWIKGNSDVKWKTETGQRVVKALTVLDELTNCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG47</accession>
    <name>A0A1U9NG47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar motor protein MotS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66902">
        <property type="protein sequence ID" value="AQT66902"/>
        <property type="gene ID" value="STSP2_00040"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00040"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MotB_plug" evidence="5">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26709" checksum="D310CC874FC1BECB" modified="2017-06-07" version="1">MPPVKEEKMKVPTYIVTFSDMVTLLLTFFVLLLTLAETQDEVLFEKGKQSFIEAVSSYGMAGYAFNQESKVEFGKETTRYKTEGKSETDEDITVDPEEETLRRIFKELEDQMRITPSQIRGANPAYSVTDIVFEAGSSTLSEKDEEFLKDFSEDLQQNVASDELTIYVVGISRDEGNISNMWQISAERAQAAADYLRGTLDEGCEWAVRSWGAGDGGRWAGEKGVISEQSDIVLSVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE5</accession>
    <name>A0A1U9NGE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flaA</name>
        <name evidence="6" type="ORF">STSP2_00023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00023"/>
    <dbReference type="EnsemblBacteria" id="AQT66885">
        <property type="protein sequence ID" value="AQT66885"/>
        <property type="gene ID" value="STSP2_00023"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00023"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43199" checksum="D5842AFE339D59C4" modified="2017-06-07" version="1">MLAIKNNLMATNAARHLGQSYDNLSQSVERLSSGLRINGAKDDAAGMAVRELMRADIAVLDQAGRNAQDGISMLQTMEGAMAVMDENLIRMKELAEQAATGSYSNEQRAIMNNEFKEMANEIERIASSTSFNGLAMLNTDEGNVSVHVGTEETIDVDKVDMTKSGLGIDIATAGYQAESDHTVTDTDTTSFLTLTGGTNESMTLNIQFDGEDAVTATFAGPTNTTTTTATFTLDDVVSAVNTAAGYTMASAEDDGSGNYSLKLESETLSSSSMTMTATTEANVAASEGFTVAGGTTDDDLTTADFTAAAGDGIHIGTEDGAVAALTAIDSAIKEKDTARAAFGYKMNRLESTNSVLNIQSENLKTAESRISDVDVATEMAKMTRNQVLAQAGVSMLAQANGMPQMAMSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG2</accession>
    <name>A0A1U9NGG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00172"/>
    <dbReference type="EnsemblBacteria" id="AQT67033">
        <property type="protein sequence ID" value="AQT67033"/>
        <property type="gene ID" value="STSP2_00172"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00172"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22490" checksum="1580F70153E03A61" modified="2017-06-07" version="1">MKIPKLKHSESIMPTAFTVGSFWRWAYSDILSNANWGVFAEYLVASALGAVDHARIEWDAFDIAYGGTKIEVKSSAYLQSWPQKRPSAIRFDIGKKLSWTADTNEYSPRPHRPADIYVFCLLAEKDRSRVNVLDTTQWQFYVLPREVLDAELGEAKTLSLKVLEGLTEPITYQKLKLAIDELVQNQKRSFQADGRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGI3</accession>
    <name>A0A1U9NGI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">thiC</name>
        <name evidence="11" type="ORF">STSP2_00190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00190"/>
    <dbReference type="EnsemblBacteria" id="AQT67051">
        <property type="protein sequence ID" value="AQT67051"/>
        <property type="gene ID" value="STSP2_00190"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00190"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="47125" checksum="1568EAFA930C089A" modified="2017-06-07" version="1">MATQLEIARAGKISDVMKRTADREGVSAELIRDELAAGRLVIPANKVHVADNLEPAAIGRAVSVKINANIGASDVSSSLDGEIEKMKMAISLGADAMMDLSTGEDLDAIRERLIAECPVMFGTVPVYEVIVGRGVEDIDHKTILEVAEKQAKQGVDFFTIHAGLLREHLPLTKKRVCGIVSRGGALMAKWMVHHDRQNPMYELFDDLCDIMREYDVAFSLGDGLRPGCGADATDEAQIAELRTLGELASRAQEKGCQVMVEGPGHVPYDQIKRNMELQQDICNDAPFYVLGPLVTDSAPGYDHITSAIGGTAAAFYGASFLCYVTPREHLGLPDVDDVRQGVIASKIAAHAADVARGFGQAAARDRRLSEARANLEWDKHIAESLDPKTAQRMHEEACARSQIADSGDSADYCTMCGRDWCSVRINREVRDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL0</accession>
    <name>A0A1U9NGL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP synthase YscN</fullName>
            <ecNumber evidence="6">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yscN</name>
        <name evidence="6" type="ORF">STSP2_00035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00035"/>
    <dbReference type="EnsemblBacteria" id="AQT66897">
        <property type="protein sequence ID" value="AQT66897"/>
        <property type="gene ID" value="STSP2_00035"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00035"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="163"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="466" mass="49542" checksum="DD1F333FCDECE78E" modified="2017-06-07" version="1">MNEMQSKLFDIGRVSAALDKVETLPTKGQIVRVSGTIVESKGPNVGLGELCGIHLDDGNRVLAEVIGFRESKLVLLPLDEINGIRPGNIVTGRAKQRNLKVGPSILGRVLDGLGRPIDGKGPLTGSDERTVENAGVCPLSRKKISEPLSLGIRSIDGMITCGKGQRVGIFAGSGVGKSVLMGEIAKSSEADVNVVALVGERGREVREFLEENLGPEGLARSVVVVATSDSAAVQRVRAGFVAATIAEYFRDQGMDVLFMMDSLTRLAQAQREIGLSAGEPPATKGYCPSVFKLLPKLIERLGCGSKGSITGMLTVLTEGDDMNDPVADSARSLLDGHMVLTRKLAEKGHYPAIDILASVSRLMTTVASDEHVAAARKLKEIYATYADAEDLINIGAFQPGSNMRIDAAVALIEDVRDFLIQHVNQRTGFGKTVARLVEIANAWDQMIAQDGQTVAAGSEANSGQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL2</accession>
    <name>A0A1U9NGL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY_1</name>
        <name evidence="3" type="ORF">STSP2_00026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00026"/>
    <dbReference type="EnsemblBacteria" id="AQT66888">
        <property type="protein sequence ID" value="AQT66888"/>
        <property type="gene ID" value="STSP2_00026"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00026"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13368" checksum="12BA7786B5EC2853" modified="2017-06-07" version="1">MAKSLLLVDDSATMRKIILRTLRMAGLDIDNFEEAGDGNEALEKLNAQPADIMLCDINMPGMGGLELVKKVREMDSCNDTKIVMISTESSDDLIESVMADGANGYVTKPFTPESIQKALSPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN2</accession>
    <name>A0A1U9NGN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67089">
        <property type="protein sequence ID" value="AQT67089"/>
        <property type="gene ID" value="STSP2_00229"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00229"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17717" checksum="D358D0328334999E" modified="2017-06-07" version="1" precursor="true">MKNPARTAKVVVSLIVSMTLGAGILMALDDKAISEGAFSLASYTRLNSIDKAANPVEAALRQWEQVEVYCANISSDTDSHFTIYNDVLGEDGVIEQTNSWRKQRSCDADGSKTIRVCVVTGVENKPSDCQLKRTAALIEKLRRKCGINNRDIYYPSNWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV2</accession>
    <name>A0A1U9NGV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67162">
        <property type="protein sequence ID" value="AQT67162"/>
        <property type="gene ID" value="STSP2_00305"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00305"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012821154" evidence="2">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="382" mass="45262" checksum="6940995EBC24590A" modified="2017-06-07" version="1" precursor="true">MLKKTVITAIVLIIAAAAQSYAAPDQPDPARRGQGRRQGMMRQQGQQGQMLCEQCRQKVQRYRRQLNAGHNVERPELCTACKQKVQQRHQRMRQGRQDRPTGDQPQRRMRQGRPGPAGDDQLAPARQGQRRHAQAQKDTPKDKPQPRKQMKQGAPERPELCKECRKKVQRYRKQMQRYKNAQKDQPGSKQRDIKADKDTTRKMDAKPQQRRRQRMHQQDCDCPDCRNMDRPQRRMQRQGRPFHGDQAPQLDRPQGRFAPRFQQQRGFGQRQQFRQDRGFPQQQGFRGQRPYGQGRQFRQQRGFGRGQDFGGQRGYGRGFSGQQQGRQFRRQQGFGQQYGPQAPRLQQFRRRQMQRFDNYDYPQPPRGPYYQPNRNYPAPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW3</accession>
    <name>A0A1U9NGW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67173">
        <property type="protein sequence ID" value="AQT67173"/>
        <property type="gene ID" value="STSP2_00316"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00316"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29957" checksum="CBD146BEDD33F9CF" modified="2017-06-07" version="1">MDSEHRHELRENELAKFLKNLPDYIREHWAAIVGWACIIAAILLWSPIREWRASKQYQQMSEVTDVIKRVEQEKGTAAMAEDGEAAIMSVGELEELGRSTDNAKLGALALCKSAEALRADVHYGDLSREEVLEETARAKKLYEDALKRAKDDPVMTGMAKFGIGLCAEEVGNYEEAEQVYNEIVSNEEFAATVYPRQAEMRLMFMQDYKTEFTFEEVVEEEAAEEDGAAVEGAEQGSVFEEAASEGEALEQVEVDPSVETEGVEAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW5</accession>
    <name>A0A1U9NGW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dxs</name>
        <name evidence="12" type="ORF">STSP2_00145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00145"/>
    <dbReference type="EnsemblBacteria" id="AQT67007">
        <property type="protein sequence ID" value="AQT67007"/>
        <property type="gene ID" value="STSP2_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00145"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="634" mass="68637" checksum="6F50EAF4BB52044C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY4</accession>
    <name>A0A1U9NGY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent helicase DinG</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dinG</name>
        <name evidence="6" type="ORF">STSP2_00142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00142"/>
    <dbReference type="EnsemblBacteria" id="AQT67004">
        <property type="protein sequence ID" value="AQT67004"/>
        <property type="gene ID" value="STSP2_00142"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00142"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="661" mass="74848" checksum="74CF70E2C66FA9DB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH17</accession>
    <name>A0A1U9NH17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67095">
        <property type="protein sequence ID" value="AQT67095"/>
        <property type="gene ID" value="STSP2_00235"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00235"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11363" checksum="569083796CCDA549" modified="2017-06-07" version="1">MFFRFSTNRFSQATNSIAATVFIVGMLLLGFSLFIFAVPELIGYIVAALFFLAGVSVLGYAVRLFIMAHQFNRRMGQDRGDRSYRRNVEIHVPDEDRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA2</accession>
    <name>A0A1U9NHA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lrp</name>
        <name evidence="5" type="ORF">STSP2_00288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT67147">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
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        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
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        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="16099" checksum="988729C4AD13FF92" modified="2017-06-07" version="1">MQPDKTDWQIIEILSKQHIPNNQIARQLGVSEGTVRRRIKALQDAGVMRVRALLDPDVLKDKQLAIILASVKESKLLKEKATEVSKLQNVNSVAIISGAYDLLIEVIVSSNRGMITFLTEQLSTVKGIEKTETHVVMKSYGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE8</accession>
    <name>A0A1U9NHE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLUG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00317"/>
    <dbReference type="EnsemblBacteria" id="AQT67174">
        <property type="protein sequence ID" value="AQT67174"/>
        <property type="gene ID" value="STSP2_00317"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00317"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866383" evidence="1">
        <location>
            <begin position="25"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="512" mass="52488" checksum="3DCE43AA79EDCF47" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ3</accession>
    <name>A0A1U9NHJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67080">
        <property type="protein sequence ID" value="AQT67080"/>
        <property type="gene ID" value="STSP2_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00220"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024780" evidence="1">
        <location>
            <begin position="22"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="642" mass="68206" checksum="7070B01091A41439" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ4</accession>
    <name>A0A1U9NHJ4_9BACT</name>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67391">
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        <property type="gene ID" value="STSP2_00535"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00535"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="70" mass="8149" checksum="D1DC5FED2C059AF8" modified="2017-06-07" version="1">MKIYSSKNRTKKGLLLGGLIGLLGPLFTRKPKPTQSDLQKADFRTSTRKMGLNFTDKLRNHFRTQWLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL1</accession>
    <name>A0A1U9NHL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67403">
        <property type="protein sequence ID" value="AQT67403"/>
        <property type="gene ID" value="STSP2_00547"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00547"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3700" checksum="B85CB1AB13DFF6EE" modified="2017-06-07" version="1">MKKFYQKHWIPFIMTKKKILILAAASYIALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM8</accession>
    <name>A0A1U9NHM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67254">
        <property type="protein sequence ID" value="AQT67254"/>
        <property type="gene ID" value="STSP2_00397"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00397"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9369" checksum="64247C323AFFEDF1" modified="2017-06-07" version="1">MLVCFGSAWPVSVYRSWVSRTAAGKSLAFMIIICTGYIAGFFHKVYFNFDGVIYLYALNALLVFADIMLYLRNKRLDQLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV6</accession>
    <name>A0A1U9NHV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GLUG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00539"/>
    <dbReference type="EnsemblBacteria" id="AQT67395">
        <property type="protein sequence ID" value="AQT67395"/>
        <property type="gene ID" value="STSP2_00539"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00539"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010732913" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="3">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="3">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="711"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1291" mass="135260" checksum="094DA0A52BE80B19" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY7</accession>
    <name>A0A1U9NHY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67334">
        <property type="protein sequence ID" value="AQT67334"/>
        <property type="gene ID" value="STSP2_00478"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00478"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572545" evidence="4">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22206" checksum="F32F6248BB412675" modified="2017-06-07" version="1" precursor="true">MKSTKLVSLVVIAAVAITVTGFQAGFAEAKKKFEPAKIGIVSVRTVLDESKSNEQWEQKINQQSKEVTEELKRLQAEAESLKQQTLALKPGTEDYAEKKRQFAEKQAILKAKDNYYQEEFGNMQKEWAEEFYQEILEAVQQAAENNNLDIVLAREDVDLPAPSARELMLTIKTTKVLYNSDHLDITDQVLAIVDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI20</accession>
    <name>A0A1U9NI20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase 2</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_00721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00721"/>
    <dbReference type="EnsemblBacteria" id="AQT67573">
        <property type="protein sequence ID" value="AQT67573"/>
        <property type="gene ID" value="STSP2_00721"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00721"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="364" mass="40749" checksum="AE7DE55E1D3C5C3A" modified="2017-06-07" version="1">MDINAKYADLLVNYSLKVKKGDKFLIRASYLAEDLVKEIYRAALQAGAHPELQISLDGTDRILYENASDEQLEYVSPTNKIVFESYDALLNILSPFNMKTLQSIDAEKKQKVSLARSDLMKTFFKRAAAGEFNWSLCVHPTNAAAQESGMSLDEYAEFVYSACYLNEDDPVAKWKQVNEQQQVICDRLNKATKIKYAGPDIDISFVTEGRTWINSSGNKNMPDGEVFTAPVEDSVNGKIRFSYPGFYMGQEIEDIRLEVKDGEVVDWSAAKGKDLLDKIFEIPGSRRFGEVAIGTNHGIKKFTKNMLFDEKIGGTVHMAIGATIPESGGKNESAIHWDMLADMTNGGHIYADDELVYENGHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI21</accession>
    <name>A0A1U9NI21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67374">
        <property type="protein sequence ID" value="AQT67374"/>
        <property type="gene ID" value="STSP2_00518"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00518"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="577" mass="61612" checksum="9B079B066904443B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI31</accession>
    <name>A0A1U9NI31_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">STSP2_00528</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00528"/>
    <dbReference type="EnsemblBacteria" id="AQT67384">
        <property type="protein sequence ID" value="AQT67384"/>
        <property type="gene ID" value="STSP2_00528"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00528"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="7"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="155"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="549"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="314"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AQT67384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1225" mass="139349" checksum="0BB1C3462021A1D7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI65</accession>
    <name>A0A1U9NI65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67619">
        <property type="protein sequence ID" value="AQT67619"/>
        <property type="gene ID" value="STSP2_00767"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00767"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="28374" checksum="973442600CD7CB81" modified="2017-06-07" version="1">MDNSFSSLCDAFYVDMQVNTELELPNQRDTVLTFFERIRKQFPAMGNFYRRESGDFCLEQEMLQERYRYVNLDTDRLCSGCVCPTTMEDAHELNMSVLELAPYMLGLSSLDIASLDLTYTMDFDCKGNHHEIVSEAFMAGTPFASFADTPGATQIGCCPSAIIAFDEDCRLQARVAVESRTPVFDIRNRKYRPGDPISIYMTIRRYPGPDAKFEAPAEYRRQVELAEQLMVEKILPNFVSPLTAAIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ4</accession>
    <name>A0A1U9NIJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67645">
        <property type="protein sequence ID" value="AQT67645"/>
        <property type="gene ID" value="STSP2_00793"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00793"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14152" checksum="71C8E265426287BB" modified="2017-06-07" version="1">MRCHKCGAETGNDNFCSRCGIELEHDTFSDAAEPIPPEHAEAGMGDRRRVSAVAVVGFLLGLGAFVMLFIDVAWFWCAMAAAVLGVVVSAAGVKVTEANKQVLSGKTAAWMGIALGAAFVLMCGALIVLGVLAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL9</accession>
    <name>A0A1U9NIL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67773">
        <property type="protein sequence ID" value="AQT67773"/>
        <property type="gene ID" value="STSP2_00922"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00922"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12581" checksum="29D3A8F0ACDCAB3C" modified="2017-06-07" version="1">MPKTFSLIIGAFVGFIFSIAGFLSHYIGVGGTFTESLFSFLAAPVLGLFALMDYLDLNMGCVGIILYFAYFMMLGGVLVIFGNWALMTATEKLADHIKQQGQDEETNESESQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM5</accession>
    <name>A0A1U9NIM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plsC</name>
        <name evidence="3" type="ORF">STSP2_00823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00823"/>
    <dbReference type="EnsemblBacteria" id="AQT67675">
        <property type="protein sequence ID" value="AQT67675"/>
        <property type="gene ID" value="STSP2_00823"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00823"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="29150" checksum="06124055B55CB454" modified="2017-06-07" version="1">MGIGKGCGWLWYRLAWVLMWVLSRTFFRMRVWGRENVPMEGPLLLLSNHQSYFDPIFCQVTQGRELWYVARDTLFRNRFFGWLIGTVHASPIKRGEMDMAAMRNIIGQLKEGKTLCLFPEGTRTEDGRISAVKGGLSLITRRTGAKALPVVIDGAYEAWGKGKKRPRFWEQIGVMIGEPFTADEIKEMGDEEFARRFTAKLREMQGELRRKLGKEAFDYGDEGGARCENLSRRNTKEKKLKGRKEDKESLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN9</accession>
    <name>A0A1U9NIN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67594">
        <property type="protein sequence ID" value="AQT67594"/>
        <property type="gene ID" value="STSP2_00742"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00742"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="22161" checksum="01C8FF32BC694188" modified="2017-06-07" version="1">MTDSGLLTNFTDTVQVKFKFLEKKFGFTLVGIDRQARTACVSYQSENVLLQITYNLVDWEIGVTFRHKDEEPLFDKFDLLYAAECQSVDFGVAFSPEMICTWLDKLTVILKTKGHGYLVGDKKAYRNLRKLANRRRNLQKQKLALDSLRDEFDRAWQDKNYHRVVDLLAPYSDLLTHTEKAKLDYAKRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP2</accession>
    <name>A0A1U9NIP2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proS</name>
        <name evidence="10" type="ORF">STSP2_00805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00805"/>
    <dbReference type="EnsemblBacteria" id="AQT67657">
        <property type="protein sequence ID" value="AQT67657"/>
        <property type="gene ID" value="STSP2_00805"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00805"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="38"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="581" mass="63514" checksum="5EAF5CEB42BF5F70" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ2</accession>
    <name>A0A1U9NIQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate-selective porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00530"/>
    <dbReference type="EnsemblBacteria" id="AQT67386">
        <property type="protein sequence ID" value="AQT67386"/>
        <property type="gene ID" value="STSP2_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00530"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165677" evidence="2">
        <location>
            <begin position="26"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="434" mass="48006" checksum="1155ABAC52709598" modified="2017-06-07" version="1" precursor="true">MVCFVNKLYLVAVTGLVLFAGGVSAEQGDSDISAKLERMEAEIAELKSRLAQKDESDAEQESDISLLSQKLDEVSAGDAPFYGSAFENWSFGGYGDVHANFNEGDGSDQFDFHRLVLYLGYDFSDWIKFHSEWELEHAYVSDDSGGEFLIEQAYFDFLLSNEFNVRAGRVLTPLGILNKWHEPTLFNGVERPSFAKYIIPTTWSSDGIGAFGRLSPEWSYEAYVVGGLDGSKFDDVKGIRGGRIKERPSLHEPAFTGRVDYRPVAGFGGGDLRLGVSGYAGGLDNGNKGSNPGIDGDIRIASADFEWSVSKFDFTGAVAHTSIDGAREIGNGTAEEMFGWYLEAGYHIWPEHWKKGKFAKTDMIVFARYDDYDTQYQMPFGVAANPAGDRNEITLGVSWKLTPDFVVKADYQIREDDSDEDLNDGINLGIGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR6</accession>
    <name>A0A1U9NIR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67811">
        <property type="protein sequence ID" value="AQT67811"/>
        <property type="gene ID" value="STSP2_00961"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00961"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341565" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="747"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129398" checksum="224FC9CBC55A00C7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW2</accession>
    <name>A0A1U9NIW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW_1</name>
        <name evidence="2" type="ORF">STSP2_01021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01021"/>
    <dbReference type="EnsemblBacteria" id="AQT67869">
        <property type="protein sequence ID" value="AQT67869"/>
        <property type="gene ID" value="STSP2_01021"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01021"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18520" checksum="85405069A376E85E" modified="2017-06-07" version="1">MAERVAKKEGGESRALLEREGKYLTFVLANEEFGLEILKVREIIGYIDVTSVPQTPGYVLGVINLRGQVIPVVDLRAKFGMELAERTQETCIIVVEFEQGGRQISTGIVVDRVSEVLDIAGENIEETPQFGSSVGTDYILGIGKIGDTVKILLDIDKVLCNSDVAGMFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ78</accession>
    <name>A0A1U9NJ78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67788">
        <property type="protein sequence ID" value="AQT67788"/>
        <property type="gene ID" value="STSP2_00937"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00937"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013318889" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15568" checksum="30EE2E576D1689E5" modified="2017-06-07" version="1">MKNLIPCLVITILCASISSAGLDFRDIPITGETVTVITGPGSFPVDSTFDIVGTTPLTDIQIPDGVTVSNPFDTIEGPFGSLPFTFDNSNLAAVPGTIFLANGQALIPYTQPDTDSSSTAITYILIPEPASLAILTLGSLILRKRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ92</accession>
    <name>A0A1U9NJ92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00734"/>
    <dbReference type="EnsemblBacteria" id="AQT67586">
        <property type="protein sequence ID" value="AQT67586"/>
        <property type="gene ID" value="STSP2_00734"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00734"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="32091" checksum="3024C4548CF1E56A" modified="2017-06-07" version="1">MNKKAFTLIELLVVISIIALLLAIMMPALGVVKQKAQGVVCTSRLKNLLIAYRTYTAENDGKLPSAYTMHPDLANTQDQADYYRTSWAWSPTRDDGSAIDWSQAQSGTVEEKINGIENGSLWPYIKDAEAYHCAADKRYTKPAEEPGWEGMGGYRSYSIPAGLNGPWQMYTEDRVYTKLSQIRRPSNVYAFIEETEGRGFNINSWALAVPEVDPGVTTEWTDPIAIMHNEASTLGFADGHAVIHKWRGKTTLEMGYNQTVRQFVDPDDEASMADLIYMREHFPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR4</accession>
    <name>A0A1U9NJR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-invertase hin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hin_2</name>
        <name evidence="4" type="ORF">STSP2_01210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68055">
        <property type="protein sequence ID" value="AQT68055"/>
        <property type="gene ID" value="STSP2_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01210"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28174" checksum="812CDFA48C354914" modified="2017-06-07" version="1">MHSDTLTGMISQPSQSTRKAILYARFSPRRNADQCESIETQFDLCTDYCINNNLEIVAKFNDKALSGSDEDRPGLWSAMDALKRGHCLVVYRLDRLARSVYLSDIIERTVKKKGASIVSISGEGTWSDNDEDWLIRKILQTLAEYERKVIAARTKAAMLRHQANGKRMSKHPPYGFTVDPLNPGRLIEHETEQQVIQQIIAMKESGLSLRAICRELQEAGINCRDKTNWHHSTVQRIIQRIDSCSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX1</accession>
    <name>A0A1U9NJX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VTC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01032"/>
    <dbReference type="EnsemblBacteria" id="AQT67880">
        <property type="protein sequence ID" value="AQT67880"/>
        <property type="gene ID" value="STSP2_01032"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01032"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="2">
        <location>
            <begin position="68"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="35492" checksum="B5CB5C3115162636" modified="2017-06-07" version="1">MAEIDRKAGLGDNESVMHTGIRRKDRVSTEQIARSVPVIRQTESPRSAAEHPRSHKPNESRDRTLSCRYELKYRISESQAAAIREYIRPYLPLDKYSKDKPRNEYSISSLYFDSEQLSLYRETRTGKKNRFKLRIRAYADGEYEPRFAEIKRRINGVIIKSRAKILPDQVPDVIAGKRIVLPHEIDDESLKQFQLYFKSINARPVTLVRYKRQAFEGDDDNRVRITFDRNLQFKSTKQPIVTVNGGGWQSVSMDFVVLELKFTARYPMWLTHLVKSFALPQSAMSKYGASVEQACEDGFCAPQVGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK20</accession>
    <name>A0A1U9NK20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01312"/>
    <dbReference type="EnsemblBacteria" id="AQT68157">
        <property type="protein sequence ID" value="AQT68157"/>
        <property type="gene ID" value="STSP2_01312"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01312"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="30562" checksum="211C036B89F38DD5" modified="2017-06-07" version="1">MEKRRVRGFTLIELLVVIAIIALLLAIMMPALGMVKEKARGVVCRTNLKTMGLAGKLYAEEEGGRLPELNFVEGLWIDKLTVYMAEVDEARYCPMAKKNIGEERGLYQFGSAFESWMWNYDDDEIQEYGSYCPNGWFTDWAANSSPPYNTPAENYFKHINTVRQASNVPIFADARWCDGWVYEDAYVPEDYDLETGESDAGYATTAGGAMVRYISNRHGKRTNVVFADGHAEAVDLSEMWSLKWHMNWKPKHDVKRGPDHDGTPIYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK25</accession>
    <name>A0A1U9NK25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01239"/>
    <dbReference type="EnsemblBacteria" id="AQT68084">
        <property type="protein sequence ID" value="AQT68084"/>
        <property type="gene ID" value="STSP2_01239"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01239"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38732" checksum="0B58E38BF4DAE611" modified="2017-06-07" version="1">MDILNTITDLSHEFGIADYVLGGGGNTSCKNSSTLWVKPSGTTLADLEPETFVALSRNQLADLYKINPPAEASAREALVKDRMQNAVLTDAGRRASVEAPLHDSLSARYVVHTHPCLVNGMTCAMEGKAVCRELFPTALWLDYIDPGYTLCMEVRNEIQNYKDQNGREPSLIFLKNHGVFVAADEPDEIRKLYAEVMSMLKASYDNAGVSLELDVGAKPEVDRIKAAESIIRDAIGMDDISIASGGRFKPASGPISPDHIVYAKSYPYIGTPTHKGIDDFKSKHGYIPQVIAFGDAVFGVSEEAKGASLALQLAQDAALVEQLAEAFGGIDYMSEKAREFIENWEVESYRKKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK34</accession>
    <name>A0A1U9NK34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lacZ_3</name>
        <name evidence="12" type="ORF">STSP2_01427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68269">
        <property type="protein sequence ID" value="AQT68269"/>
        <property type="gene ID" value="STSP2_01427"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01427"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866387" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="10">
        <location>
            <begin position="279"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="430"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="9">
        <location>
            <begin position="546"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135838" checksum="C313A7481F74729F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA5</accession>
    <name>A0A1U9NKA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01511"/>
    <dbReference type="EnsemblBacteria" id="AQT68351">
        <property type="protein sequence ID" value="AQT68351"/>
        <property type="gene ID" value="STSP2_01511"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01511"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14930" checksum="51B26433E84EF311" modified="2017-06-07" version="1">MAENDKEKKIIVDEDWKSQAKKDKDALEAEEKAAQEKQQAQGGESSRPPLPEVDFAGLISMFATQAYLAMGLIAADPNEKPEPDLELGKFNIDMLALLEEKTRGNLDDEEKNLLSGALHQLRMAYVALSKQQGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA8</accession>
    <name>A0A1U9NKA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01108"/>
    <dbReference type="EnsemblBacteria" id="AQT67956">
        <property type="protein sequence ID" value="AQT67956"/>
        <property type="gene ID" value="STSP2_01108"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01108"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="334" mass="38430" checksum="3393323D9BD1C9F9" modified="2017-06-07" version="1">MVIKCKNWKPSPKPLHGICKAGKLGGEPVVSACIDVCGQCQNSSEDFRNYLSSRFGTGKMAADNKKVIIESQPQRHRAWHKDVFYRGDGTTVDLVDLFHGQSVFLICNGPSIKDIDLEKLTSTPGVMTMSLNNGGHKIRTNLWTGQDPPYRFMQSIWEDPSIMKFTLYDYRKRPVWDRKKGGYSDLKLWQCPNTFFHKRHSDFDAKKWLDEDKVVWGEPKDAGGNRSVMLAALHILYFLGFRNVFLLGADFHMTSDDKYFFEDRAAVKHNNRLFKNVAKYLEQLKPYLNEVGFRVFNCSPASHLKVFEHKSIHDAVEMCRVNISQSTEGMYVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC4</accession>
    <name>A0A1U9NKC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator protein VraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vraR</name>
        <name evidence="3" type="ORF">STSP2_01194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68040">
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        <property type="gene ID" value="STSP2_01194"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01194"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="12072" checksum="B491B336CCCE7BE0" modified="2017-06-07" version="1">MWNEDDIQGQLFSCDEWEMLVGDLGLSRRQGELMYLLVHGYSDRQIGGKLGISLATVRTHISRLFQKFDLQDRVELNCLVFGKFREQCNRMDCPRNRTRCGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD9</accession>
    <name>A0A1U9NKD9_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01140"/>
    <dbReference type="EnsemblBacteria" id="AQT67986">
        <property type="protein sequence ID" value="AQT67986"/>
        <property type="gene ID" value="STSP2_01140"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01140"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002084" evidence="2">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="609" mass="69949" checksum="0AF49997AEB9B08C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG0</accession>
    <name>A0A1U9NKG0_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68389">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01549"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="722" mass="81159" checksum="F96A569BA97BA6E8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH6</accession>
    <name>A0A1U9NKH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein FixJ</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">fixJ_2</name>
        <name evidence="3" type="ORF">STSP2_01474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="protein sequence ID" value="AQT68315"/>
        <property type="gene ID" value="STSP2_01474"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01474"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22204" checksum="3FD729413CF0F16C" modified="2017-06-07" version="1">MENIKENGNHPVCVIHPEKSFREIIKQHICEKGFECHCYGGNDGFFQDFDGDQAGVLITPAQTRDGFDNEIKQIKQTCPGFQVIALADNASVEEAVELMRKGAFGVVEPSKFDQQLFKELENAFEQIGCYSKLADLTPTEKVVLGHLLEGMGNKQIARKMHRSVRTIEDHRANIMKKMEAANVVDLVKKALAFGYCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68120">
        <property type="protein sequence ID" value="AQT68120"/>
        <property type="gene ID" value="STSP2_01275"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01275"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="45" mass="5200" checksum="E6FEEEE76680382F" modified="2017-06-07" version="1">MKYFGVDVYLFLFLVFGCGRVVREELWALLCICTVRVFLGVHADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY9</accession>
    <name>A0A1U9NKY9_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798476" evidence="1">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32289" checksum="BDBB58241F4EAD88" modified="2017-06-07" version="1" precursor="true">MNRIAIYTFLCVLTALTAFSTEAIIAGSGTDDSADRKGPTLYLGLQGHEKAVNEIESFMYFVPMISPVTMKSSTSEVNTQKVTIIDCKRDISRRDFEISCVFEVTGQGSYRHTYDARQMIEWNTRKHKKGDTVKNLLDYIEFTGSGRGSFEIKGRFRDGNAQVEEVEVNFSRDGKDSPVTVGLYSIEAKNGRYHYDNRTDERIAQIEKLAFKDTEGNPKMSIKVGSVRDADKDKSLFGSLCGMIANLLIDPIAINKQGNDAMLDLGMAIYEKQETFTFRKAANLSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL14</accession>
    <name>A0A1U9NL14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L,D-transpeptidase YkuD</fullName>
            <ecNumber evidence="5">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ykuD</name>
        <name evidence="5" type="ORF">STSP2_01578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01578"/>
    <dbReference type="EnsemblBacteria" id="AQT68418">
        <property type="protein sequence ID" value="AQT68418"/>
        <property type="gene ID" value="STSP2_01578"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01578"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="387" mass="43716" checksum="7D43A1FC479EDB62" modified="2017-06-07" version="1">MARRRRKYPKYRSRYSSYGRRAAQRKQRRLMVLGVLVIAAVFLFFKFRGDDEQPEVVGVDDSIINDINPDFGEDTSSANTSAESSNKPSPEPASDPVSETQTKPEVVTQPKVEAPKPEPVEVVEKKETVKDKVASEPAAKELTAKAVQDMRAGKTIAARDKLNEVLDMKLSDSDREKVKAALADLAERWLFSPEVLPGDELSEYYLVQRGDYLSEIGKRYKVPYQLIMKINGIPSANRLRAGQKIKVVKGPFNVAIFKSDFTMDLYLQRTYVKSYEVGLGSMEHETPSGKWRVEPNDKLKRPNWTDPDTGETFIASDPEYPIGERWIGIEGIEDKTRDKTGFAIHGTNEPESIGKRASRGCIRLKNTDVIEVYNMLYTGDSLVYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL15</accession>
    <name>A0A1U9NL15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68599">
        <property type="protein sequence ID" value="AQT68599"/>
        <property type="gene ID" value="STSP2_01767"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01767"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="90" mass="10059" checksum="F652451884F0842A" modified="2017-06-07" version="1" precursor="true">MRNWRGKMLMTLVVYFAGFATAIYTLAPASDEVNSPRTTAGRELTEQPQSKGDKVMARLGEDIQKYAHLAQEKAVIVKTLIESKLEKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL57</accession>
    <name>A0A1U9NL57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01628"/>
    <dbReference type="EnsemblBacteria" id="AQT68464">
        <property type="protein sequence ID" value="AQT68464"/>
        <property type="gene ID" value="STSP2_01628"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01628"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="57076" checksum="A8E0E6CDAB203BFA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL62</accession>
    <name>A0A1U9NL62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68246">
        <property type="protein sequence ID" value="AQT68246"/>
        <property type="gene ID" value="STSP2_01402"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01402"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12654" checksum="706BCC5D5990526E" modified="2017-06-07" version="1" precursor="true">MSKNSLIAGALFALYKRSLTHAYASFRMNQLQKQRQRMIQKYVEHFEGQLKDKGGKIVSTIAIILSCRKGLSKKDIEAIVDGIVDSDDIDVAVLGMHIYNKLLEMKVLRQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA4</accession>
    <name>A0A1U9NLA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68722">
        <property type="protein sequence ID" value="AQT68722"/>
        <property type="gene ID" value="STSP2_01894"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01894"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="7">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="29689" checksum="D2E42160687DB24E" modified="2017-06-07" version="1">MAKKNKTTARTRSQSKTVKSNQKKKRSKNFNPILRFSPTAWAKLLYFRDKSDNEVAGFAVTDTDDLLYVREFVTITQQVTSVTVSFHDEAVADYFDRQVDAGKRPEQFARVWLHTHPSDSPTPSATDNETFARVFGSCQWAVMFILAEDDNTFAKLRFNVGPGADMLIPVRVDYGCQFGPTDHDSWDAEYEQNVIEIPWASTSADALNLAGSEHDEFWDDLVVSNDMIDQLEALDPATRRSVMDELAQRPDLWDDESEVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB4</accession>
    <name>A0A1U9NLB4_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68732">
        <property type="protein sequence ID" value="AQT68732"/>
        <property type="gene ID" value="STSP2_01904"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01904"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="20459" checksum="7CA13692A894DF7F" modified="2017-06-07" version="1">MQVIRIDYANPNYMSPNYVPEYLHQAVPVYQQGCYNSAWSVDDIVSSPTTRPSENSEENIFADKQKTSYLALENIVAQIRKRYEIYDSNIRVLEYSKIKLKEHFYQWPQQLGLWPPGHKEMLSEQMNQLYQKQLDEKVSLWKDVSKLKLMLPQSLNDYLSIKRKSDIYSGGVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE8</accession>
    <name>A0A1U9NLE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01795"/>
    <dbReference type="EnsemblBacteria" id="AQT68627">
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        <property type="gene ID" value="STSP2_01795"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01795"/>
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    </dbReference>
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        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="301" mass="34338" checksum="A9859F3B0BAB7566" modified="2017-06-07" version="1">MSDHTKELREMKPTSDYLVAIDSDGCVFDAMGIKQRECFCPMLIAHFGLQPVAEAARDCKDFADLFSKTRGANRHKTAVRILTELLPSHPMVKERGFDVPNYPHYVQWVNEPDSLLSDAGLKKAIAEERREEARKELEMVLKWSQRVNEMVAEVVKNVPPFPYVRESLEKIEGTADIIVCSSTPTEALKREWAEHGVAKYVKVIAGQEMGKKEEHLAVMCEKYDKDKIIMMGDAPGDMKAAKKNDVMFYAINPGAEAMSWKRFHDEAFDKFMAGEYAGQYEQMVIDEFDEYLPENPPWMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG9</accession>
    <name>A0A1U9NLG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01845"/>
    <dbReference type="EnsemblBacteria" id="AQT68675">
        <property type="protein sequence ID" value="AQT68675"/>
        <property type="gene ID" value="STSP2_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01845"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012979340" evidence="1">
        <location>
            <begin position="23"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="322"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="529"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="716" mass="78724" checksum="99BE905AFE3E3856" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP6</accession>
    <name>A0A1U9NLP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid A biosynthesis lauroyl acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">htrB</name>
        <name evidence="7" type="ORF">STSP2_01827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01827"/>
    <dbReference type="EnsemblBacteria" id="AQT68658">
        <property type="protein sequence ID" value="AQT68658"/>
        <property type="gene ID" value="STSP2_01827"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01827"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="37888" checksum="B479C096A4AAB225" modified="2017-06-07" version="1">MSAEKRKKRKKKKKHNPVSDYLTYLGMRLGVAIMHCFPVENNLRFAKKLGSLMWKHYHRGRDRALTNLHASFPEKDEQWIHATGQRSFQQIVMLVVDILFTPKLVRKDNWQQYSRFINAERIKWMMKEEKGLLLLTAHYGNFEIMGYMMGLFGFNIYSIARPLDNKFINNWLYGIRKRKGQKIIDKKGASAIMTQVVDEGATLGFIADQDAGKKGVFVDFFGRKASTYKSIGLMAIQYNLPIGVGCCRRVDDRFFFEMEVQRIITPDEWADKDDPLKWVTQEYSKAMENFIRKDPTQYWWLHRRWKHRPREERKKTARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR2</accession>
    <name>A0A1U9NLR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolG_5</name>
        <name evidence="3" type="ORF">STSP2_01844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68674">
        <property type="protein sequence ID" value="AQT68674"/>
        <property type="gene ID" value="STSP2_01844"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01844"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="182"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48630" checksum="8A7787720473D39F" modified="2017-06-07" version="1">MSQSNRFNRRQFLKASAGVIGAFTIVPRHVLGGNGHVAPSEMLNHAIIGCGGICSAHLGYVAEDPRRKLVALCDVDSDRLAGKLAGVDKGVKGYEDFRDVLARPDVDVVHVATPPHWHGLMSVAAAEAGKDIWCEKPMTRTIYEGQKVVEAVQRNNRIFRINTWFRFKGGFAGGYHTYDGSGAEVRPTRKLVKSGLLGWPLKVTIGRASGLNWKQDVWVGKTGLVPQSVPDNLNYDMWLGPAPRKYYHPHRTHASFRGYWDYDGGGLGDMGQHYLDPVQFILGKDNTSPQEVIVETQQQHTDAVLPWRRVTYKYADGCEVILDGDNRDENAAFIEGPGGKLYKNFKSDIPNIKQKVAEMPDLEPVVTDFTEAVLNRKKFALNEVNGHRSCTMVNMAKIAVRLGRNLKFDPDKQMFIGDDEANRMMRQPMRAPWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM27</accession>
    <name>A0A1U9NM27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68959">
        <property type="protein sequence ID" value="AQT68959"/>
        <property type="gene ID" value="STSP2_02136"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02136"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="28021" checksum="75051DC11AA6E3A6" modified="2017-06-07" version="1">MTWFLLTLIVFAPKIKEVPLAPTEQQVDTRYAHTNSHIDDAMADDDPSVSQAELDRRKARNERIAQYRSKYGRLSGRTREEDPQPASNNAQQIDARSLLESKIDFSVFKEDMTVEDAFDKLQESGLPLIVMWRDLERNAFVDKTTTLGVEGNGIIPMKKALDLILKGVSSYDTRLVYVCDGGAVTVATEQADIVKHYLEVYDIAELAGSGMFLNNQRNGRGGSYSNQQGYGNGGYGGNYQGGGFNRGSGYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM29</accession>
    <name>A0A1U9NM29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68885">
        <property type="protein sequence ID" value="AQT68885"/>
        <property type="gene ID" value="STSP2_02062"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02062"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20397" checksum="151DB74B8D9442EE" modified="2017-06-07" version="1">METSAILGQRRRNSRKAKTDSSSDTVSDVWAPKGSRPTAVKQTEYDWVYIFGAVNPVNGKSSAVITPTVNTDYMNHHLRFISEEAGKDVHVVLVLDQAGWHIAKQLVVPKNISLLHLPAYSPELNPIERLWAYMKSHYLSNRVYKNYEEIFNAGTVAWNNITSEMFCSICNTEWIKHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM53</accession>
    <name>A0A1U9NM53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68814">
        <property type="protein sequence ID" value="AQT68814"/>
        <property type="gene ID" value="STSP2_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01990"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="35" mass="4217" checksum="E391CB2DB33D9A13" modified="2017-06-07" version="1">MRSSYIWRLFERVPKTGQVFKVELFSGILSRKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC2</accession>
    <name>A0A1U9NMC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
            <ecNumber evidence="3">2.7.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptsH</name>
        <name evidence="3" type="ORF">STSP2_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02054"/>
    <dbReference type="EnsemblBacteria" id="AQT68878">
        <property type="protein sequence ID" value="AQT68878"/>
        <property type="gene ID" value="STSP2_02054"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02054"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11356" checksum="98ED49B973C45DAB" modified="2017-06-07" version="1">MAENIKDIEVEIKNADGLHMRPAMQFVDIASKYDSGITVSNGESTVDAKSIMQVTMLAATCGTRLQIHIEGEDAEDAAEDLRQLVEDKMFDEPAGAPSGDDGRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK0</accession>
    <name>A0A1U9NMK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basal body P-ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flgI_2</name>
        <name evidence="4" type="ORF">STSP2_02135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02135"/>
    <dbReference type="EnsemblBacteria" id="AQT68958">
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        <property type="gene ID" value="STSP2_02135"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02135"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="559" mass="60766" checksum="00429C6297F0FB71" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM4</accession>
    <name>A0A1U9NMM4_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="AQT69202.1"/>
        </source>
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            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP4</accession>
    <name>A0A1U9NMP4_9BACT</name>
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        <name evidence="4" type="synonym">ltrA_3</name>
        <name evidence="3" type="ORF">STSP2_01949</name>
        <name evidence="4" type="ORF">STSP2_01983</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01949"/>
    <dbReference type="EnsemblBacteria" id="AQT68776">
        <property type="protein sequence ID" value="AQT68776"/>
        <property type="gene ID" value="STSP2_01949"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68807">
        <property type="protein sequence ID" value="AQT68807"/>
        <property type="gene ID" value="STSP2_01983"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01949"/>
    <dbReference type="KEGG" id="alus:STSP2_01983"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="Group_II_RT_mat"/>
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    <dbReference type="InterPro" id="IPR000477">
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    </dbReference>
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            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="524" mass="61429" checksum="C786FCB1D3462223" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN08</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">STSP2_02478</name>
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    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69289">
        <property type="protein sequence ID" value="AQT69289"/>
        <property type="gene ID" value="STSP2_02478"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02478"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3392" checksum="4BD263510217C992" modified="2017-06-07" version="1">MKSLACGANKCVTKTREVSNVETERVMLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN12</accession>
    <name>A0A1U9NN12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02305"/>
    <dbReference type="EnsemblBacteria" id="AQT69118">
        <property type="protein sequence ID" value="AQT69118"/>
        <property type="gene ID" value="STSP2_02305"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02305"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025832">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032626">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16216">
        <property type="entry name" value="GxGYxYP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_N" evidence="3">
        <location>
            <begin position="64"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP_C" evidence="2">
        <location>
            <begin position="302"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="552" mass="63172" checksum="55C8B0D554991834" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN29</accession>
    <name>A0A1U9NN29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxynorspermidine/carboxyspermidine decarboxylase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nspC</name>
        <name evidence="11" type="ORF">STSP2_02395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carboxynorspermidine + H(+) = CO2 + norspermidine</text>
            <dbReference type="Rhea" id="RHEA:34099"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57920"/>
            <dbReference type="ChEBI" id="CHEBI:65070"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carboxyspermidine + H(+) = CO2 + spermidine</text>
            <dbReference type="Rhea" id="RHEA:34095"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:65072"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.96" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02395"/>
    <dbReference type="EnsemblBacteria" id="AQT69207">
        <property type="protein sequence ID" value="AQT69207"/>
        <property type="gene ID" value="STSP2_02395"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02395"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045312">
        <property type="term" value="P:nor-spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06829">
        <property type="entry name" value="PLPDE_III_CANSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005730">
        <property type="entry name" value="Nsp_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF1">
        <property type="entry name" value="PTHR43727:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038941">
        <property type="entry name" value="NspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01047">
        <property type="entry name" value="nspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="10">
        <location>
            <begin position="131"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038941-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="379" mass="42492" checksum="AC8B9E385C068A76" modified="2017-06-07" version="1">MNYDLSKITTPCYLVDRGLLRKNCETLADVQNRTGCRILLALKGFAMWSVFDIVCEYLAGTAASSLHEARLGREEFGKEVHLTAPAYRDDEFDQLIANSDHIIFNSANQWQKFKPRIAAGSRALKCGLRINPMHSEVKTAIYDPCSPGSRLGITRDLFPADMLDGITGLHFHTLCELNADSLQRTLAAVEKQFGEFIPQMQWINFGGGHHITRPDYDIDLLCKLISDFQSKYDVQVYLEPGEAIALNTGFLIATVLDIVHNACDIAILDTSAAAHMPDVLEMPYRPQISGADEPGKKPHTYRLAGPTCLAGDVIGDYSFDAPLKPGDKLIFHDMAHYTMVKNTMFNGINLPDIVTYEPDTDDYKLQRRFTYQDFKTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA2</accession>
    <name>A0A1U9NNA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02396"/>
    <dbReference type="EnsemblBacteria" id="AQT69208">
        <property type="protein sequence ID" value="AQT69208"/>
        <property type="gene ID" value="STSP2_02396"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02396"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="396" mass="44694" checksum="B2A7C1B8CF67F8E9" modified="2017-06-07" version="1">MSRVLIIGAGGVGNVVVQKCAQLPEIFTDICLASRTKSKCDEIAAMLDRPIETAQLDADDPKQTLALITRFRPDLVINVALPYQDLPIMDACLEAGVDYLDTANYEPPDEAKFEYKWQWAYDDKFRDSGIMALLGSGFDPGVTNVFCAYAQKHYFDEIHFVDIVDCNAGEHGHPFATNFNPEINIREITQKGKYWEQGDWKEIEPMSVSKDIDFPEIGPRKAYLLYHEEEESLVKHINGLKRIRFWMTFGEAYINHLQVLQNVGMTSIEPVEFEGKQIVPLQFLKAVLPDPGSLGVNYKGKTCIGCIMEGVKNGETKRIMIYNTCDHAKCYEEVKAQAVSYTTGVPAMIGAAMILTDQWHKPGVYNMEQFDPDPFMDMLNKHGLPWKVIEGKTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA5</accession>
    <name>A0A1U9NNA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">STSP2_02572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02572"/>
    <dbReference type="EnsemblBacteria" id="AQT69383">
        <property type="protein sequence ID" value="AQT69383"/>
        <property type="gene ID" value="STSP2_02572"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02572"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="536" mass="57512" checksum="4733F99388519F55" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH1</accession>
    <name>A0A1U9NNH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">STSP2_02347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02347"/>
    <dbReference type="EnsemblBacteria" id="AQT69160">
        <property type="protein sequence ID" value="AQT69160"/>
        <property type="gene ID" value="STSP2_02347"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02347"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="116"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="247"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35992" checksum="AD92DE29CFA901E9" modified="2017-06-07" version="1">MNEAKLAGEYFNAVIAGTGSAVPENTLTNEDLTKIVDTSDEWISTRTGMKVRHISGDDDTTATLAASASKEALADAGVSAEDVDLIICATITPEMVFPSTACFVQDMIGAKNAWAFDLSAACSGFVYALSVATRFVTCGKYDNVLVIGAETLSKITDYEDRNSCVLFGDGAGAVVLKKSEQGDAGVKYSCSWSDGSGWTALNCQAYGSRHPVSKPLDDPKKVYMNLNGREVYQTAVRRIVELVNECLNKCNLDISDIDMFIPHQMNARIIESVAKRLKFGKDNVFINIEKYGNTSAASIPLALDDCIKDGKVKSGDTILLAAFGAGLTWGATVIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI9</accession>
    <name>A0A1U9NNI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69304">
        <property type="protein sequence ID" value="AQT69304"/>
        <property type="gene ID" value="STSP2_02493"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02493"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31269" checksum="546F94ACBB9FFC19" modified="2017-06-07" version="1">MRVKRGFTLIELLVVIAIIALLLSIMMPALSMVKEKARLVVCGSNQKQLIYGVSMYGTEHDGKLPPNPNWVGGNNYHRPTELNWYGNGVGTLDPTLSNYHPVGKYLGGYLPDVGVYNCTVAPIAKDTPWPPRGSKVESVGTYNEVYQDYDFAPLHATYMLLWNYQGYNQSVSTGGAQGENFVAPSKMSSKNQLILQDSLFYLPQGQGNLLWETPSNSWYSSHNFGGATKVDPYFVMDGPQDEIPDEIDINAGYLDGSVQRFKSSECYWVKNWSAAAGLVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ8</accession>
    <name>A0A1U9NNQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoserine phosphatase RsbU</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsbU_3</name>
        <name evidence="3" type="ORF">STSP2_02743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02743"/>
    <dbReference type="EnsemblBacteria" id="AQT69551">
        <property type="protein sequence ID" value="AQT69551"/>
        <property type="gene ID" value="STSP2_02743"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02743"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="522" mass="59303" checksum="D20F16F9E4B89061" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP21</accession>
    <name>A0A1U9NP21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69468">
        <property type="protein sequence ID" value="AQT69468"/>
        <property type="gene ID" value="STSP2_02658"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02658"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="14125" checksum="FDB590AA23C5578C" modified="2017-06-07" version="1">MQLHVLPRRKSKSRQNHNLETIRILEEKQRALEESWLYDLEPLARLLSELHESNFELTTPPDEAINAALAAWQLGGEACMRKLRDMTIERSKPDQAQTLSQCLDFWWDGIGSWRLEPALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP30</accession>
    <name>A0A1U9NP30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02853"/>
    <dbReference type="EnsemblBacteria" id="AQT69659">
        <property type="protein sequence ID" value="AQT69659"/>
        <property type="gene ID" value="STSP2_02853"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02853"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25787" checksum="C83B6218AFBA549E" modified="2017-06-07" version="1">MLITALSDIHGSLEALNSSKSLLSDLASSDLVLIAGDITNFQGKTQTAEVITAIRRHNPNIFAVPGNCDTAAVDEYLREQNINLHCQTRKHADFTLTGVGAHVPCSRNDQACSLEEKLQVCLDHIAEMSHAENNLIFVAHYPARHTAVDSIGDNHHGGSWNIRDFIEQAQPLLALSGHIHDAPGTDHIGRTTLVNPGSLRDGSYAQIRIEHERVRVHIGCIKKRWREHFGYGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP78</accession>
    <name>A0A1U9NP78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="5">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dus</name>
        <name evidence="8" type="ORF">STSP2_02905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02905"/>
    <dbReference type="EnsemblBacteria" id="AQT69709">
        <property type="protein sequence ID" value="AQT69709"/>
        <property type="gene ID" value="STSP2_02905"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02905"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="7">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="37566" checksum="BF8DC6D0DDFC9955" modified="2017-06-07" version="1">MLEIGNIELDVPVMQAPLSGYTDAAMRVVAKEHGAPLTFTGVMLDKTLLCEKAVRKGIFHPAKGENPVGGQVLGRDPVKMAKAAAVFERLGYDMIDLNIACPAPKVLRRGRGGALLGEPERVIEIWRRVREAVSFPVTMKLRIGVGSDDGTEDNFWRICETVCDEGIDAVMVHGRTVKKKYKGKADWDIISEVKRRFPETNVIGSGDIFTAEDAVERLRTENVDGVLVARGAIGNPWIFDEIRALLAGEEKPGNPVLKEQGRVILRHFGMVSSLREKLKGVRYFRKFAAGYCKRHPERKKAMLGIMGAKSRDEVIAQIEKWYGVNAEAILAELEQDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA5</accession>
    <name>A0A1U9NPA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol hydroxylase P5 protein</fullName>
            <ecNumber evidence="7">1.14.13.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mphP</name>
        <name evidence="7" type="ORF">STSP2_02740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.13.7" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02740"/>
    <dbReference type="EnsemblBacteria" id="AQT69548">
        <property type="protein sequence ID" value="AQT69548"/>
        <property type="gene ID" value="STSP2_02740"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02740"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018662">
        <property type="term" value="F:phenol 2-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="211"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="49807" checksum="F5588C8E61B94D3D" modified="2017-06-07" version="1">MQTTDYRYRLGWLDSRFWAVVLVTVYMLVAAGPAVLSVFFQPGGDEPVLVEIGFAAALTGFSLICLQVLLAGRFHGVDRPFGLDCVMNFHKAMGAFAACLLLAHPVLLALGFQSWGLFGLDTGWQVNLGKAALAIAIVGVPFSLTFLKLGVDYNIWRVIHKGMILIVLLGFLHGLFIGPDLRIPAVRWYWIGLFSVTAAVYLYRNIYVPRWGRRRFDITEVKQTTHDTWTLTFKPKDDGTIWRNPGQFMFVKFKRPGRKSEQHPFTIAAGPEDDDLLQATIKESGNFTNTIGQTKAGDQANIEAPYGRFSIAYHDVKEILFIAGGIGITPIMSMIRHLRDSGDQRPVKLIWGVKTEQDIVFRDELESLGANFEVTYVLSRPGEDWNGESGYVTAEVIDKYSKDMLRSADVFLCGPPVMMDKVIAALRKLRVDDKRIHYERFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE8</accession>
    <name>A0A1U9NPE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69812">
        <property type="protein sequence ID" value="AQT69812"/>
        <property type="gene ID" value="STSP2_03009"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03009"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301704" evidence="1">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="512" mass="54457" checksum="21FF698F42F23C48" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG0</accession>
    <name>A0A1U9NPG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemin transport system permease protein HmuU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmuU</name>
        <name evidence="8" type="ORF">STSP2_02921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02921"/>
    <dbReference type="EnsemblBacteria" id="AQT69725">
        <property type="protein sequence ID" value="AQT69725"/>
        <property type="gene ID" value="STSP2_02921"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02921"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="345" mass="35913" checksum="D8BC2717D36272C6" modified="2017-06-07" version="1">MAMLDGRKVTARILIMTAALIIIALLCSMLGTEDISLSQVWKGLSQDESATALNADYEIFFHIRLPRIILAGIVGAALACSGVVFQALLRNPLAEPYILGISSGAGLGAMLAIIAGLDIVFLGRSAVAPFAFVGAIGTVALVWAVGRYACRASMTGLLLAGVVVNAFFSSLIMFITSIAESDKVFSTIFWLMGNISEQAAIGLWLLSGLVLTGIVGLFYLAPGLNAICFGEAEAKSVGVNVTAVQWTAFGISALITAAAVSVSGLIGFVGLIVPHAVRLVFGPDHRQLIPLSALSGAAFLIAADTLARVIVAPAQLPVGVVTALIGGPFFLILLIRQTRRRGGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG5</accession>
    <name>A0A1U9NPG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69500">
        <property type="protein sequence ID" value="AQT69500"/>
        <property type="gene ID" value="STSP2_02691"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02691"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165682" evidence="1">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29219" checksum="3848F8EF12FF99C0" modified="2017-06-07" version="1" precursor="true">MKQRQDLLLLLFGVFVLICSISFTAAQPAGTMDAEQLRIEIMSSPSGFNLTYREILHEDFKTHDQAVRRSFKQLADGLDFYLKGDLVRAHRELAEVSRNAQVSDYADSSLPGSLSLQSILNESSTRLPEQDCSKCGGLGYVDCSVCGGSGWSVCLTCRGDGKIEDRVRYRSQAGQMETKVVEAQCRDCAGLGVRPCEECDMRGIIPCDECGVEKQGSKVFERDVEHVIKIMQIIEHARFIAGGGLEFFSRAGLAVSPKLSNTVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ6</accession>
    <name>A0A1U9NPJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xcpT_11</name>
        <name evidence="11" type="ORF">STSP2_02832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69638">
        <property type="protein sequence ID" value="AQT69638"/>
        <property type="gene ID" value="STSP2_02832"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02832"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSG" evidence="10">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16116" checksum="28F9B5D6CF6DBD0B" modified="2017-06-07" version="1">MRAKRRNRRAFTMVELIAIIVILGLLSAVAMRSFTGVMDKTRVQTTKSSLKTLHDAVIQFKFETGRYPSEDMGLEELVVEPTDVTGWTPGGYLETTEVPQDAWGNDFVYMRHPDSGKPFVIISYGADGEPGGEDYNADLYSTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL2</accession>
    <name>A0A1U9NPL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin-coupled histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gchK</name>
        <name evidence="3" type="ORF">STSP2_02972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
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        <property type="gene ID" value="STSP2_02972"/>
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    <dbReference type="KEGG" id="alus:STSP2_02972"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAF"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
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        <property type="entry name" value="HATPase_C"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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        <location>
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            <end position="404"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="406" mass="45566" checksum="962EEE41EDD023EF" modified="2017-06-07" version="1">MQDSAEKTLVDQSQTDQPQSQIDPMECLDLIRDLCPDNLNNDNMDDFLDTARTRIQEFLGFENCYFIMKSAKGKMPDIARMKQKDENFTPSAAMVENAATNETNIITEDAPHSTSYIGDPDFQRYNTLAAAAIVLKTAETSYGILYVDSTTEKTFTDTQKTFLEFLGTQLGLVLDNAAKKRLAAAGKATLHLSHSVKNILQMVTGASEVIDFGLRTNQIHRVVRSWQILKPNLERMRKFMLDMLDYSKDRKIETGPCEFNRVIQGAIESLNSQLKQKKFRLNIRVDQDIPTVELDSERIHEMALNLILNAVDIIDENTGVVNVETKYRKTEELVELSVADNGPGMTEETKKRIFTPFESGKNKFGTGLGMAIVKQVVDKHNGTIEIESEPGEGAKFILLLPAKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL7</accession>
    <name>A0A1U9NPL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cph1_9</name>
        <name evidence="5" type="ORF">STSP2_02889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69694">
        <property type="protein sequence ID" value="AQT69694"/>
        <property type="gene ID" value="STSP2_02889"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02889"/>
    <dbReference type="Proteomes" id="UP000189674">
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
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        <location>
            <begin position="720"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="679"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="962" mass="108155" checksum="B1F43CA0A1CA80F3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN4</accession>
    <name>A0A1U9NPN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03073"/>
    <dbReference type="EnsemblBacteria" id="AQT69873">
        <property type="protein sequence ID" value="AQT69873"/>
        <property type="gene ID" value="STSP2_03073"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03073"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045692">
        <property type="entry name" value="DUF6057"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19529">
        <property type="entry name" value="DUF6057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="616" mass="70149" checksum="F619835569D2A04C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX0</accession>
    <name>A0A1U9NPX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69981">
        <property type="protein sequence ID" value="AQT69981"/>
        <property type="gene ID" value="STSP2_03181"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03181"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20172" checksum="2E542CBF2C960125" modified="2017-06-07" version="1">MARGPNEKNFGADIEKGLAEQVNAYIDQHGLVRRKLMTVLLELFMRLPEHVKAMLLHAPAGSEGFEELVRGIVRDELARSGVDAEEKPREPEPLGEAVAAVEDAQTHFEVLAPEDQAKLNDLRTKLAPKPAGNEREQMQELKEAFKSCDEKVREEFSKMIADQEGVSQRLKKLEEKENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY3</accession>
    <name>A0A1U9NPY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queE</name>
        <name evidence="7" type="ORF">STSP2_02864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02864"/>
    <dbReference type="EnsemblBacteria" id="AQT69670">
        <property type="protein sequence ID" value="AQT69670"/>
        <property type="gene ID" value="STSP2_02864"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02864"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="25312" checksum="B04A46B4BF1787BA" modified="2017-06-07" version="1">MIINEIFYCLQGEGKLAGTPSALIRLAGCPLRCRWCDTKYACPTTAGQPRTPEQILTEISEYPTRHAIVTGGEPLAQQDTPHLLQALEHAGMHVTIETCGIHYHENIPCDLMSISPKLSNSTPDDPELASPHDAARLCPEILQKLIDNYDYQLKFVVDTPADLDEIAELLDSLNNVNPYKVFFMPQASTRDEYLQKSQLVAQICEKTGFKMSQRLHILLYDGQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ1</accession>
    <name>A0A1U9NPZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iolG_9</name>
        <name evidence="4" type="ORF">STSP2_02991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69794">
        <property type="protein sequence ID" value="AQT69794"/>
        <property type="gene ID" value="STSP2_02991"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02991"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459824" evidence="1">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="3">
        <location>
            <begin position="201"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="48055" checksum="F5C8E2709CC3A923" modified="2017-06-07" version="1">MRRRDFCKAAVSVPFFLSSSVLGNDAPSNRLNMASIGTGRMGRGDMKSCLYNGLKRNIRIVAVCDVDRSRALAAKKAVEDIYTKQLGQGNFTEVQAYTDYRKLLARKDIDGVTISTPDHSHALIAVAAAKAGKDIYLQKPLTYTIAEGRKLVKAVRSNNVILQTGSQQRSSVYFRKSCELVRNGRIGKLRKIEVVIPTDHGTADASPMPVPANLDYDMWLGPAPKVPYTDHRVHPQNGFSRPGWLQIGQYCHGMITGWGAHMYDIAQWAMGTDKDSGPVKVKAQAEYPDRGLFDVHTAFTADAEYANGVKLTSHNGSPGVKFIGTDGWIWVERGSFKAHDMNIFREKLSDTDVKLPVSNNHMGNFLDCMRSRKDPLAPVEVGHRSNTVCVIHHIAMKLGRPLQWDPKTERFVNDDQANAMLDYEHRQPWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ7</accession>
    <name>A0A1U9NPZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02779"/>
    <dbReference type="EnsemblBacteria" id="AQT69586">
        <property type="protein sequence ID" value="AQT69586"/>
        <property type="gene ID" value="STSP2_02779"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02779"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="416" mass="44305" checksum="488DB8052BC990AD" modified="2017-06-07" version="1" precursor="true">MTYKCIKKSHHSRKGAALALAAMVVVIMLLAGMALLRVGLNSRVYANKTVNELIARSAADAGLNEAFSLMQKKLATSHLPGNSWNNSTLPSTTDRTLDASDATYSYAVSGSPINGFVIASTGECSGQQRTVNVSITTQTPFTGIGVREVIDIKTGVNFYKTPEDGLFILRTNSSETGCISINSWVTVPGDVVIGPGGIPETSIDTKSNTVIEGGSYSATEEINFPPVYAPSGLPLMEYQQGNTITLNSSGQYEGITIGNGETLMIDDGVPGTTKKLTIYISGDLILNNGASMILAEGTALDLYLGGNWEDKNSSSAGGFFNENTISDPITAAQLLHVYGLPGCEKISFKAKSDFAGAVYAPDADLILHNSGDIYGAFVGNNFEMKNSSSFTYVADLMNGMIDDPITVFARQRWWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ02</accession>
    <name>A0A1U9NQ02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/panthothenate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_03001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69804">
        <property type="protein sequence ID" value="AQT69804"/>
        <property type="gene ID" value="STSP2_03001"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03001"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="523"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="549"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="616"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="686" mass="76781" checksum="99CCD2381421F35E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ15</accession>
    <name>A0A1U9NQ15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylmenaquinone methyltransferase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiE_2</name>
        <name evidence="2" type="ORF">STSP2_02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.163" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69606">
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        <property type="gene ID" value="STSP2_02800"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="229" mass="26466" checksum="A3C20EC1DA24F087" modified="2017-06-07" version="1">MSVPVYKNPKQALKATDQFYANQAGFQYTEELVTDWTRKFVNIPAKGNVLDLCCGDGIWSRGFQVNNPQLDLYGVDISEGGIEKAKRLLDTDDEHFFVCNVEVELPFSDNFFDLIFARGPGLYNQHSMDRPQTIRVIEQWHNKLSDRGLFYSIFASRPEVMGTYTPMKNVKLPYNRSPRKSDTIDFSGGKYHHTIQSFLTPFWKASNVEVKKYSFFNNLHVLITRKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_03177"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AQT69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8509" checksum="ECFF7FD5513047D5" modified="2017-06-07" version="1">MARTRRTIRLSDHIGEQMEAYKDSTSIPYQDIGDVGVFLAVRLTPNSFFKIKAKIRTGEELEPGDVEFAGDEENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG2</accession>
    <name>A0A1U9NQG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">STSP2_02943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69746">
        <property type="protein sequence ID" value="AQT69746"/>
        <property type="gene ID" value="STSP2_02943"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02943"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19323" checksum="B1AE02DFA7A5D9F0" modified="2017-06-07" version="1">MRIFSGGEVRFSAVIFVLLCVTGFICGCGEPRLAPKRSEAPLRAESPADMRILGLTRVETKGDSGKKLEVFLELRNSSGEQLRTPARFLFEMYKYQPRSSEPAGQRLQIWDPVEVTRDDLAGGGGYWLTFLEAYSFELDLGGYAGRVGDYLLQVTCFTADGRRLTDTLRLKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH8</accession>
    <name>A0A1U9NQH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RecB family nuclease, family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03070"/>
    <dbReference type="EnsemblBacteria" id="AQT69870">
        <property type="protein sequence ID" value="AQT69870"/>
        <property type="gene ID" value="STSP2_03070"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03070"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="168" mass="19469" checksum="75364D3087F621E9" modified="2017-06-07" version="1">MKTRAYLDIETTGLSRSRAELTVVGIAIERPTAMGEEPLDLIQLVSPEIDEPGLYKSLESVDEIYTYNGSRFDLPFIKSSLQADLKTKFRHTDLMYHCWKRKLKGGLKSVERQLKIERNLTEVDGYQAVVLWWQYINHNDQNALKTLLEYNAEDVINLQHLRLKLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT9</accession>
    <name>A0A1U9NQT9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pncB2</name>
        <name evidence="11" type="ORF">STSP2_03499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03499"/>
    <dbReference type="EnsemblBacteria" id="AQT70293">
        <property type="protein sequence ID" value="AQT70293"/>
        <property type="gene ID" value="STSP2_03499"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03499"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="155"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="429" mass="48823" checksum="88B02A76DA729283" modified="2017-06-07" version="1">MYLLNQSPALLTDLYELTMAQVYWQKDFNDHACFEVFIRKLPDDWGFFVMSGLAELKSYLQNVRFTEDDIHYLRTLDMFDPAFLDYLQNIDFESVEIRALPEGTPFFPNEPILEVKGPILTAQLLETYILNILGFSIIQATAASRLQIAAQGRAVVDFGMRRAQGPVSSIRAARGAVTAGMPATSNVLAAKLLNAKPSGTMAHSFIQAYTKEEDAFESFARTYKSKAVLLVDTYDTVNGIKLAAKVARKLDTEDNIQIRGIRIDSGDLVKMSNFARRHFDENNVEWIKIFVSGNLDEYKIDDIVQQRGQVDGFGVGTSLAVSRYAPSVDIAYKLVRYGDRDVYKKSENKATHPGRKTLHRTFRDNRYEHDDVIKYQPSSDDLLRPFSEPEPLHKIAERLNTMLYHLAPAYKKIRNPETFPVNFHIKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV6</accession>
    <name>A0A1U9NQV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70124">
        <property type="protein sequence ID" value="AQT70124"/>
        <property type="gene ID" value="STSP2_03328"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03328"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6086" checksum="CBF9AFB7A327D234" modified="2017-06-07" version="1">MKDNSKHYRGAASGRERSSNKNKHDRILADAVETAMQLMEGLKSSSYDTANTQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR08</accession>
    <name>A0A1U9NR08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70349">
        <property type="protein sequence ID" value="AQT70349"/>
        <property type="gene ID" value="STSP2_03555"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03555"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18562" checksum="33C639BB35E3304A" modified="2017-06-07" version="1">MNKKAIVYFFATVAVLALVVWLASSIRQHWQDRKVKPILVEWADHDERVDIIFQNREVETLTSPDEIKSFHSNISEALIGHVKNVKSELLEYACNFEIVLTGSDKKIVLSFDVYPKPIDADAAEWSIREGYILYSDITLILDKHAASELVKILTKGSGYPEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR20</accession>
    <name>A0A1U9NR20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage N-6-adenine-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70070">
        <property type="protein sequence ID" value="AQT70070"/>
        <property type="gene ID" value="STSP2_03272"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03272"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008593">
        <property type="entry name" value="Dam_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05869">
        <property type="entry name" value="Dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19945" checksum="81D3BA9DD3D8A9E8" modified="2017-06-07" version="1">MKSSGFSHDFKKNKTNEWYTPTYVFDSLGIKFDMDVASPGKDIVPWIPAKKHLTIRDDGLHSQWQGTVWCNPPYGRETSNWLEKMYEHNDGIALVFARIDTSWFYDYCRPANALLFLKGRVKFIRHDQASAYVQDGKVKNNGSGAGSMLVAYGERCERALFGASSRLGPVFRYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR21</accession>
    <name>A0A1U9NR21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69966">
        <property type="protein sequence ID" value="AQT69966"/>
        <property type="gene ID" value="STSP2_03166"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03166"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="31134" checksum="1504D1DA9C1E250A" modified="2017-06-07" version="1">MSYTMHTLAGVKYDTTLIKGITAQTFSQQLVELLEGGNGSVDNGFSAVAGADPQLTFTTTAIKTALATLGDIDGKAIAASNFVMWFQAVTNGGTREGATSHIKGTAVQGLIIPQTLTLPHRGKATLQYLCIFVSSDGSTAPIAFTGSQSLDTGEGAADELYTLGACEINGTAVEAVQQAVIDFGITPWTEGGSGDKYRSFAAIGTRQPTITLETSQIGNITSDNWGILGAAQDETEGSESVINAAALTNGGTLAGTNVSFTVNRGRIQLEPISGSSGQRLGTSIKITPIYDGSNDVIAVGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB4</accession>
    <name>A0A1U9NRB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decaprenyl-phosphate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.45" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03551"/>
    <dbReference type="EnsemblBacteria" id="AQT70345">
        <property type="protein sequence ID" value="AQT70345"/>
        <property type="gene ID" value="STSP2_03551"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03551"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34201" checksum="08FE41D57954399B" modified="2017-06-07" version="1">MASRSAVADYLKLARPHNWIKNVVVLMPIIFGMSMHIPSAWLHSIAAVIAFCFVSSFAYILNDIRDLEADRRHPVKRTRPLAAGKISVKDALIEAVILMIFAAAISLAVSPALLAMIILYAVLQVAYSLLLKNFVLIDVIVIAIGFVLRAVAGAVAISVQISPWLFICLFTICLFMGFCKRYNEMMTLANGKDAHYHRATLIEYTPDLLTHLISTSAGIAIITFLLYSISERTTAAFGTNYLVYSLPFVVYGIFRFALLSMKGAYSDPTDIMLKDRPFQATVMLWIIFAAIITLYGKEIAAWFRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB5</accession>
    <name>A0A1U9NRB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70160">
        <property type="protein sequence ID" value="AQT70160"/>
        <property type="gene ID" value="STSP2_03365"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03365"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="45317" checksum="A662678D2718D212" modified="2017-06-07" version="1">MAGVLLIIIIVIMWVGLGLTAKKRQAQNDHNSSINRTQQKDDGHKRLTCQVDLLRQATESGQEDIFSIRIRGQINAPEAGHETDAQVILSDITENESFAQPVLCTVQKWQMEDSPAFYHRDYYGKLMQRLSMLSYWTAVLELPCNTLTLPRRGTRRLKFTVSLLSRGTENEIASASTIITYKSSRPGYIDITENARVTETLTIQLATAALGPENIENESAGAVLEDWIAGKIESIDDEQARKHVLNRLADTAQDAAILCKSGQGLDTLAICEKLASVSSIADRYAAMELFLQMLACHYNGSPEHNLAATQAAQGLQIEHDKLRAMVQKTLPIMEAEHRDSNFLLGITDDMLSGDIRKKLSSEYKKWNSRVNHPDAKVRAKADFMLELIADARSNCTTEKIAAAGSEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG93</accession>
    <name>A0A1U9NG93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66949">
        <property type="protein sequence ID" value="AQT66949"/>
        <property type="gene ID" value="STSP2_00087"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00087"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19788" checksum="326D6C5EC3080012" modified="2017-06-07" version="1">MQCPVCSNGLKKVNVEGIELDVCDGGCGGIWFDSRELDKVDNAREAAGEQLLDIQRKVNISADQRGKIKCPRCMDITMMKHFYSVNQSVEVDECGGCGGFWLDYGELGQIRDQYETEEEKKAAAKAYFDEVFGEKLAKMRVEEEAKQAKARKIASFFRFICPSWYVPGKQKWGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP2</accession>
    <name>A0A1U9NGP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lysine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00239"/>
    <dbReference type="EnsemblBacteria" id="AQT67099">
        <property type="protein sequence ID" value="AQT67099"/>
        <property type="gene ID" value="STSP2_00239"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00239"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022525">
        <property type="entry name" value="GNAT_AblB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03827">
        <property type="entry name" value="GNAT_ablB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="278" mass="31328" checksum="18F06EE604BFD365" modified="2017-06-07" version="1">MSFDKTEILRNSLIQHGKSSDRVYLMKLAEQDLPDIIGDIEELAKKNGYTKIFVKVPMKLGVDFLSRGYVTEATVPDFYDGSEKAVFLAKYFDERRSNDPNVKVIAQNLKLAKEKAGTAKNIVIEPELDIGRTTDQDFDEMAEVYKTVFATYPFPIHDPAYLKETAESHVQYYAVRVDGKIAALASSEMDVKGKNSEMTDFATLPEFRKKGLAKKLLTTMEKDMQEQGLKMAYTIARAMSPGMNITFSQLGYEFGGTLVNNTAICGQIESMNVWYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT2</accession>
    <name>A0A1U9NGT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_00283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67142">
        <property type="protein sequence ID" value="AQT67142"/>
        <property type="gene ID" value="STSP2_00283"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00283"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="46307" checksum="D0FDD81C2040E43A" modified="2017-06-07" version="1">MSWKSEWKKLAAIVVAFVGAFYLPVGWERFENSIIESLALVRWYAREHVLLCLVPAFFIAGAISVFVSQASVMKYLGAKANKVLAYGVASVSGTILAVCSCTVLPLFAGIYKMGAGIGPATAFLYSGPAINVLAIVLTARLLGAELGIARAVGAIIFSVVIGLAMSFIYRKEEIEKANGEMVVPDDGDSRPLWQDALYFASMVGVLVFANWGKPGEDSGAVWRWIYDAKWVITSGFAAAFGVILIAWFKLAWWKIGATAVPVAVTAMLWPDHAMIPFVIGVIGLSVITSTSGGETEEWFESSWGFAKQILPLLLGGVLVAGFLLGRPESEGMIPSEWVAKAVGGNSIWSNLFASVAGAFMYFATLTEVPILRGLIDSGMGKGPALALLLAGPALSLPNMLVIRSVMGTKKTAVYVGLVVVMATISGITYGTFFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT8</accession>
    <name>A0A1U9NGT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66968">
        <property type="protein sequence ID" value="AQT66968"/>
        <property type="gene ID" value="STSP2_00106"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00106"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25692" checksum="C5CE0EE1926A4F11" modified="2017-06-07" version="1">MEIHQPIAYNKLSDEGNRVLKGFGVIKYHILLLFVFCGSSLAQLTRYVDKAQFVDAVPPIVATESFEDLATDASSAQRNTIELAQVTISTLDTSLSVHNTPEYGQQPTDGSQYVRISGGDEPGGREITFDFITPVNWFGLNIIDWGDGTVNGSGELVARVDCTEYIDITQGTKPDGNVTFFGFSSNNPFDCITIYNDIPTDSWAIDELYFATPEPATAVIFAAGTLMLARRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH03</accession>
    <name>A0A1U9NH03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67212">
        <property type="protein sequence ID" value="AQT67212"/>
        <property type="gene ID" value="STSP2_00355"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00355"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="18118" checksum="CAA526909D7ED17B" modified="2017-06-07" version="1">MKRRFSLYLLIGVILYAISNTGLKLAFQEHRASFYHYSDTNNLFNVIYALHSLFLLFLFMFSIGVICKKSKYLMLKMFVLGVLFCLSGFFFVLDHAEATRIVSKQKGRAALTKEYGDRFVNLLSKTDNEKMPSVDDWRDTVFSNNIHSLVFSAVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH21</accession>
    <name>A0A1U9NH21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67067">
        <property type="protein sequence ID" value="AQT67067"/>
        <property type="gene ID" value="STSP2_00207"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00207"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030184" evidence="1">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="45453" checksum="8085318960C4878F" modified="2017-06-07" version="1" precursor="true">MKRLFALIIVLAAAGVSFGVDVDFKLTDNGDGTGTLSWTINKPDTEIVGMALNVDCIEGQIGSVQIDSYFDVFPDAAHSDPTLYDGALSPNQLGSPIAPQAFPGTTTLPNSSFCISVAHLEGETDGTGIILGSGTSVSGEIDINAIRGGIVDQNGDAMTTNLPFQFGTGCGCFPCGHPDYGEWVSVGMPESWCNEYQCEGDSDGLTEGSPFTGYYRVGVNDLNLLVWGWKDTNYVDPATDPWIAADFDHAEEGSPFTGFYRVGVNDLNILIANWKDDTNVTGECLDDRLIILSLQSSAEEIECFPAEHPDYNTWMEVGRPESWCNEYQCEGDADGGVEGCPFGGFYHVGVNDLNLLINGWKQTHYSDPATHPWIAADFDHKVEGSPFTGYYRVGVNDLNILTANWKDDYDLEGDCLEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE1</accession>
    <name>A0A1U9NHE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67341">
        <property type="protein sequence ID" value="AQT67341"/>
        <property type="gene ID" value="STSP2_00485"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00485"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="57190" checksum="747F0553E1BC08FB" modified="2017-06-07" version="1" precursor="true">MNRRDFLRTAGIVTAGLTVNAADVRAEKKSAAENKSKDQRPNVLWIVSEDTSPDFACYGEKLVKTPNVDRLASEGAMFTNAFAACPVCSPTRSAFNTGMYQTTIGAHHHRSHRRDGYKLPEPVKHVSDMFRDAGYYTFNSNGLNWKKPGKLDYNFKLDGNAFDGTDWRDRKNGQPFYGQVNLFLTHRKFKRDKDRPIDADDVKLPPYYPDDPLTRRDWADYLESVQVLDGMIGEVLDRLEADGLADNTVVFYFGDHGRAHLRAKQWLYEGGIRVPLVVRWPDKIAPGTVRDDLVSQIDFVPTSLAACGIDTPDYLQGVDFLGNGETDREYIFAARDRCDETTDRIRCVRTKRFKYIRNFYPDRPYTQMNCYKMQAYPALSLLQLWKQQGKLTDAQKPFMADVRPKEELYDLQSDPWEINNLAGDAKYADKLAELRGVLDKWIEETEDKGQTPEDAQTRKYWQNFFEKRYAKIMKNRGLGEDPSPAQRVAWWREKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF9</accession>
    <name>A0A1U9NHF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00388"/>
    <dbReference type="EnsemblBacteria" id="AQT67245">
        <property type="protein sequence ID" value="AQT67245"/>
        <property type="gene ID" value="STSP2_00388"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00388"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="17088" checksum="09B3FDD01992117A" modified="2017-06-07" version="1">MTRPFFDEFFADGDNRKIAEQEQLLMDVAGMLSELMGKKGVKNKELAETLNKKAPQVTQWLSGTCNMTLRTLSDILYALDTKLQVKPQPLIDEIVVDYKRSAAGNRAIDRYLCRKGDNFVVRFEGKDRTAGCWREQPMNVRKQTRLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH1</accession>
    <name>A0A1U9NHH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA_3</name>
        <name evidence="1" type="ORF">STSP2_00351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67208">
        <property type="protein sequence ID" value="AQT67208"/>
        <property type="gene ID" value="STSP2_00351"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00351"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38949" checksum="F48E849CBD25024E" modified="2017-06-07" version="1">MIYDAAGRRISKAVGGDTTEYVYDGDQVIAEYDDSGEIIRKYIYSPGIDEPICMIAGSDTYWYHRDGLGSVVALSKYDSSAGFASIVERYTYDPFGQTTVCDGNGTPRQDNLTAFANPYQYTGRRYDPETGLYYYRARMYDTELGRFLQPDPIGYADGMNMYAYVGNNPTTFIDPLGLRQWSGLLRPNAMVRIQAKSGKRERHHISDVTDLVMVLIEHAVSKDEIVSFEYYGHGDTSGEGLNIEVKDKKSYITGIFTEGNSVVDNKNAYGLGALRGIIEGAFAVDAKISLNACYSANGKNSIASGFKEILPNADVFGYTGVAMVDPLFGKSHPADSGSEFVEMKSDTKGCENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH7</accession>
    <name>A0A1U9NHH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division ATP-binding protein FtsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsE</name>
        <name evidence="5" type="ORF">STSP2_00104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00104"/>
    <dbReference type="EnsemblBacteria" id="AQT66966">
        <property type="protein sequence ID" value="AQT66966"/>
        <property type="gene ID" value="STSP2_00104"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00104"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24570" checksum="19546A679F6147DF" modified="2017-06-07" version="1">MIELNAAKVYPWHGQISEQVCKVMRMFGISVGTMRERGLRYELDLAIEPGQICYLSGPSGSGKSTLLRELYEATTEQKVRLEDIELSETQTLVDCIAGETTLGKLLTLSKAGLSDVFTVLNKPANLSEGQKYRYRLACAIAGDSQVIFADEFCSNLDRIGAAVIAHNIARFARRSKKIFVLAGARDDFLADLRPDVIVKIELGGRTEVIRREREAGDGRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI5</accession>
    <name>A0A1U9NHI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67392">
        <property type="protein sequence ID" value="AQT67392"/>
        <property type="gene ID" value="STSP2_00536"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00536"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21827" checksum="F429D17E0E75490D" modified="2017-06-07" version="1">MKLAHVENPTKYKGLYIIDYGDHSSIGYTADEVAQILESEQYANVKVYKIRRAYPDGQMELKGVPAETFHLEMGMFFYAHNEKIARKQYDRLIEDTQTHPAPARAVVQLAKLDAQTYVTALIFPAEHNDEFSSWLIDCDYRTTGQVTGGVSALIEYRSRGPQIIESTQLHAPDRQDRPAEELFAKTGEAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN6</accession>
    <name>A0A1U9NHN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase, DNA ligase-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00430"/>
    <dbReference type="EnsemblBacteria" id="AQT67287">
        <property type="protein sequence ID" value="AQT67287"/>
        <property type="gene ID" value="STSP2_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00430"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="33716" checksum="4238ECA2574CB2FB" modified="2017-06-07" version="1">MITQKQIKQNGPLFIISDLHLGSGGARDEFASSNKRKLLAEFLDMVESEAGQVVILGDLVDLWRFNLRSVVRTHRELFDRLYEMNAIYVVGNHDRGLRSLKAQTVHPLLGNVTGPVKIIHGKRDLVLMHGHEVDAMNKFIRPGFGKMLGISAYPIERWTGGQVFTSEVIADKILELQSWFLTAILNMGRQMNSFINPHDSLKHLSRDEVFASLRKRRDHKFVRMHEHRKADQEDTMLVSAHTHRAGRFSDWYFNSGSWTGIKQNFLRILPDGLVDIADWTTSGIRPLENQFLSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP2</accession>
    <name>A0A1U9NHP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67441">
        <property type="protein sequence ID" value="AQT67441"/>
        <property type="gene ID" value="STSP2_00588"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00588"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6397" checksum="436533322B33E495" modified="2017-06-07" version="1">MQEYVDSNVMKMKNLYVYGNYIDEVLAAGGTSSVYFLQDHLYSPVAVLDTNGSTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP4</accession>
    <name>A0A1U9NHP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaA_2</name>
        <name evidence="8" type="synonym">dnaA</name>
        <name evidence="13" type="ORF">STSP2_00421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00421"/>
    <dbReference type="EnsemblBacteria" id="AQT67278">
        <property type="protein sequence ID" value="AQT67278"/>
        <property type="gene ID" value="STSP2_00421"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00421"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="135"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="439" mass="49237" checksum="84DFCE451992876D" modified="2017-06-07" version="1">MAGQDSAAIFDKICEKVRKLDPVNTRKWFDDLVLAQFDGGLLQIGCPDETKAQYLEDTCQSVFSQAAQSITGHLVGVEFTVADRKPQPQQKSRKVEAGENVKLHPDYTFENFVVGPCNRLAHASCIAVSNSPGNTYNPLFLYGTVGLGKTHLQHALCHEARNREPNTRIRFLSCEQFVNKFISAIEAGNLLDFQTELRSVDILVIDDIQFLREREQSQEEFFHTFNALYNNRKQIVLTADCAPGELPAIEDRLISRFKWGLVCRMDPPSYETRVAIVQKKAHLRGLDIGDDIAEFIADKVKANIRELEGALTIIYATAQTTDEPITLDLARQALGDTVSTVEKNITISDIIGVVTDHFSVRLSDLQSKKRSQSIALPRQICMYLARNMTRHSLEEIGGHLGGRDHTTVLHACNKITELEKNDQNMRNQLAELSKVIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS2</accession>
    <name>A0A1U9NHS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00618"/>
    <dbReference type="EnsemblBacteria" id="AQT67471">
        <property type="protein sequence ID" value="AQT67471"/>
        <property type="gene ID" value="STSP2_00618"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00618"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19119" checksum="3A21AC1B2D3EA065" modified="2017-06-07" version="1" precursor="true">MLIVAACSLVLPITSCSKAPEDEMLEACKDGDWAAMQNVFDRNPDILQGDKGVDILIEACKAEKADIAAKLIQAGVDVDGMSSGGVTPLVFSLRTDKPRMVKLLLRYDADPNKSAGTFELHPIFYAIRSGNIQNLSLLIEAGTNVNVKTSLGWTPLHVAVNTNTTNAQPRYSSAVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS3</accession>
    <name>A0A1U9NHS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67469">
        <property type="protein sequence ID" value="AQT67469"/>
        <property type="gene ID" value="STSP2_00616"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00616"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7578" checksum="A70B983F6081EAEF" modified="2017-06-07" version="1">MNSGVYGRWVRACAPAMFSGPRLGGRGDDLFSRLLFLCWVRLRRMTGTVLVREKVDLFFVEEGFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV0</accession>
    <name>A0A1U9NHV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lpxA</name>
        <name evidence="7" type="ORF">STSP2_00481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00481"/>
    <dbReference type="EnsemblBacteria" id="AQT67337">
        <property type="protein sequence ID" value="AQT67337"/>
        <property type="gene ID" value="STSP2_00481"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00481"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29659" checksum="CB8C376BBF70ED71" modified="2017-06-07" version="1">MGNNIHPTAVIEDSARLGDNVTVGPNCYIDKDAVIGDNTVMDANVIIGKSVKLGSGNTLFANSVVGRPPQLLGWTEEQKVGQLEIGDNNTIRENVTIHPSMHPGELTKIGSDNLIMVGVHIGHDCILEDKIVVSNYTQISGHCKVETGVWLSGIVAVHQFVTLGKWCYAAGLSGINHDIPPFVIVSGHYPNEVRSINKRGLKRAGYDDQTKESIMGAFKKIYKSNGIFIDRVKELAKESDLDPNVRYMVEFIIRSQEHRFGRYLESFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW5</accession>
    <name>A0A1U9NHW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="14">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="14">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">glmU</name>
        <name evidence="16" type="ORF">STSP2_00468</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="14"/>
    <dbReference type="EC" id="2.3.1.157" evidence="14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00468"/>
    <dbReference type="EnsemblBacteria" id="AQT67324">
        <property type="protein sequence ID" value="AQT67324"/>
        <property type="gene ID" value="STSP2_00468"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00468"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="15">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="14">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="14">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="254"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="404" mass="44076" checksum="E57D4C275065C07A" modified="2017-06-07" version="1">MAQKVAIIMAAGQSTRMNTKLPKVLHEVCGRPMLSYVLDACRQAGVDRIIIVVGYGKEQIIDRFGDQADITFVEQKEQKGTGHAVMCCRDELERFKGQTLILCGDAPLIRSETLKTLIEKHEQEKSAATLATTILDNPAGYGRIVRDSYGNIQGIVEHNDCTDQQLQIKEVNPGYFCFETPVLLDALKEIKPNNVKNEYYLTDALHITIATGGKVTAVTAVAPEDAMGVNNRRQLSQASKIMQERIQDKLMDAGVTIVDPPNTWIDVRAQIGQDTVIEPFTYIHGQVSIGTNCRIGPFAFLRNGTQIGDDVVLGVFTEIKNTRLADGVRARHHSYLGDAEIEANSDIGAGALTANFDGQKIQKTKIGPNTFVGPGAVLVAPIEIGPDSHLEPGKVVTQKDLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI44</accession>
    <name>A0A1U9NI44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_00594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67447">
        <property type="protein sequence ID" value="AQT67447"/>
        <property type="gene ID" value="STSP2_00594"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00594"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010736548" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="346"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="528"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="631"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120090" checksum="B1F3143CF5032EB8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA0</accession>
    <name>A0A1U9NIA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uvrC_1</name>
        <name evidence="4" type="ORF">STSP2_00615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00615"/>
    <dbReference type="EnsemblBacteria" id="AQT67468">
        <property type="protein sequence ID" value="AQT67468"/>
        <property type="gene ID" value="STSP2_00615"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00615"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="3">
        <location>
            <begin position="240"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="448" mass="51756" checksum="D4E8CA1B00A6720E" modified="2017-06-07" version="1">MHEKTPDENRLDRIRAKIKDFPAAPGLYFMKDARDTVLYIGKAKNLRSRVASYFQRSSDLASSRGQWIVDMVSRTRTVDYLECESEIDAVLREARLIKDIHPPYNSQLTDDKSFPYLEITTQDDFPGVYITRNPKSDKSRLFGPFTTGRDLRAVLVLLQKIYKFRTCHLEIDAADAKRRFFRPCLLYSIKQCTAPCAARIDKDEYRKLIGDLTRFLNSKRSTVLADLRRKMNKASKDLDFERAAMYRDRVRLIERLDERGSVEDHVQPEVFAKDPTDALDRLRKILKADEPIRIIEGFDIAHISGTDTVASLVKFIDGRPFKSGYRRFKIKTVKGIDDYASMKEVITRRYRQAAKGEELLPDLILIDGGRGQLNAALAALHEIDAPVPLIIGLAKKHEEIFTPDREDPIRLAAHNPARKLLQYVRDEAHRFAQHYHHILRKKSLLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA8</accession>
    <name>A0A1U9NIA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00820"/>
    <dbReference type="EnsemblBacteria" id="AQT67672">
        <property type="protein sequence ID" value="AQT67672"/>
        <property type="gene ID" value="STSP2_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00820"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143320" evidence="2">
        <location>
            <begin position="21"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="464"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="660" mass="71970" checksum="90F51DBD00FABDE7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE9</accession>
    <name>A0A1U9NIE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00851"/>
    <dbReference type="EnsemblBacteria" id="AQT67703">
        <property type="protein sequence ID" value="AQT67703"/>
        <property type="gene ID" value="STSP2_00851"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00851"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036466">
        <property type="entry name" value="UCP036466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="5871" checksum="8F4DFB0E9E3DC9CA" modified="2017-06-07" version="1">MGLLGWALTFLIVAIIAAVFGFSGIAAASAGIAKILFFIFLALFVVLLIMNLLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH2</accession>
    <name>A0A1U9NIH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67306">
        <property type="protein sequence ID" value="AQT67306"/>
        <property type="gene ID" value="STSP2_00449"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00449"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="341" mass="38637" checksum="1AE9C46AF2B6E523" modified="2017-06-07" version="1">MNKIQVTSQLKKLLLVIFLTVLIWAWAYNALEDTTTQPATLSIYQSPDSALLVEFVDRESPIDFEITVKGPASGISELERKVLTGEEKLDFVFNAKTERKDSPGRYVLDVLQFVKNSAKIEVLGLTVESVSIDTVEVEVEQLVQKQLTVQVLDENGLPLEHEDIKPSFVETYVRPQSTTDSLKARVTLTPDQIEKARKGYITAQPIVEISPNEFRQAAAVQIKLPPTADTLENKLLPYLRVGFLMGDQMEGRYEVELINANEVVSTTRFQATDEAWAVYENMPYQIVIPVYENDAEQEKVTREVIYNFPHEFLEKGEIKLTGSPRTAEFRLLPVGEQNQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII7</accession>
    <name>A0A1U9NII7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00892"/>
    <dbReference type="EnsemblBacteria" id="AQT67743">
        <property type="protein sequence ID" value="AQT67743"/>
        <property type="gene ID" value="STSP2_00892"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00892"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18497" checksum="39D012DDD38A4687" modified="2017-06-07" version="1">MIESLNLDDLDKRIISALQQDFPIAQRPYDSIAENLGLSVDVLLERTRKLLADGMIRRIGFSLDSRKLGYKSTLAAVRIPSDQVPTAASIMADIPEITHSYERADEFNVWFTVIAPARNDIEYILKKIKDALNLSDADILDLPASRLFKLDARFSPQTEEDCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK9</accession>
    <name>A0A1U9NIK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67564">
        <property type="protein sequence ID" value="AQT67564"/>
        <property type="gene ID" value="STSP2_00712"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00712"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28601" checksum="C45FD6070D58E3F0" modified="2017-06-07" version="1">MPPVLTILKKRWQEVLLIAILGSGIFIPSMLLGLNDAAGQEPEVSEWSLFAMVAGVTFFAVFYVMITMGFLETAYREGTYQQDPAKLLIIGRRFFWRMLRFNIIIGLVSSVIIFAFYVVIHRMILQLPPDEAPSVWVQQISAFFTSIIVARPVLLIPPIFITTGTNEALKAFSLSKKFPVKSMVGPIVIYVVCQAVANGLMQAWPLMKDTGPIRYIPLAVIGVAAGLLFFVPYLPAMKYITERMPSPPEREDPGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ1</accession>
    <name>A0A1U9NIQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67812">
        <property type="protein sequence ID" value="AQT67812"/>
        <property type="gene ID" value="STSP2_00962"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00962"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3454" checksum="95608831C33CE848" modified="2017-06-07" version="1">MTRKTKIFLYIMLAVGAALMITGVLLEQVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU0</accession>
    <name>A0A1U9NIU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00573"/>
    <dbReference type="EnsemblBacteria" id="AQT67426">
        <property type="protein sequence ID" value="AQT67426"/>
        <property type="gene ID" value="STSP2_00573"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00573"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6464" checksum="C326F5A88EFA42DE" modified="2017-06-07" version="1">MKVRVDDSCTACGLCVDTCPEVFQMGDEFAEVIADPVPPEHEDSAQQAADECPVDAIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX2</accession>
    <name>A0A1U9NIX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00822"/>
    <dbReference type="EnsemblBacteria" id="AQT67674">
        <property type="protein sequence ID" value="AQT67674"/>
        <property type="gene ID" value="STSP2_00822"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00822"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20327" checksum="6DF125D2E6C93380" modified="2017-06-07" version="1">MPKQNGRKTEIFVDLLTANYHSISSFVHSQILDSSDAEDVMQETTSMLWQRFDEFEIGTNFAAWASTVARYRILEFRRQKKKNHPHLSPKTLEILSGEADHALQDTAPKLKALKKCLSELPVKDHRVIDMKYRHGIGVNSIADKFQTSASAIYRTLTRTKEVLMRCVNKKIKHEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ01</accession>
    <name>A0A1U9NJ01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WLM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01064"/>
    <dbReference type="EnsemblBacteria" id="AQT67912">
        <property type="protein sequence ID" value="AQT67912"/>
        <property type="gene ID" value="STSP2_01064"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01064"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="26481" checksum="542FC9B831B8C76F" modified="2017-06-07" version="1">MEFAYTVKRSRKRKKLTITVERDKSVVVHAPFELPDDRIGEILESKKAWVFEKLTHSQKYSDLPHPPGKELVNGESALYLGKLYRIELVEQLEEICFSNRFLIPSSQQHQRKTVLKNWYIAKAKEKLLPKAVGHAKELGVNFNHIKIVDNRYRWGSCTPRNNVNLNWRLIKAPMFTVDYVIVHELAHLLEANHTANFWSIVRTHTPKMEKARSWLKENGQILEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ56</accession>
    <name>A0A1U9NJ56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67951">
        <property type="protein sequence ID" value="AQT67951"/>
        <property type="gene ID" value="STSP2_01103"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01103"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13720" checksum="CB2495A27FB2A419" modified="2017-06-07" version="1">MDISNVMEMIWRFCNSSFGFAAVWAATVGFFLWLGSRYNPFELKWKKYEGSIITAIRLAEKQIPDDTDNAGMRKLDWALRFVLQAYAKANGSQPSQTTIEQLKEGIQIKHNELAVAGALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ85</accession>
    <name>A0A1U9NJ85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DarT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67989">
        <property type="protein sequence ID" value="AQT67989"/>
        <property type="gene ID" value="STSP2_01143"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01143"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029494">
        <property type="entry name" value="DarT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14487">
        <property type="entry name" value="DarT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DarT" evidence="2">
        <location>
            <begin position="184"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="40028" checksum="6032A9DDD501814F" modified="2017-06-07" version="1">MGREWFGLGLQRWQIQSNRFLRSFYSIIQDAKLFLLDLVFIKSKLSITLIVQIAKGENLFMAPFFVIIFLFAIWPPLGVLALIALIFWVCIREDDGPGEQNTNFSANEHWKSPFDEEDDFYPGLSSSKTRPVFRSYDDWDDCDCCAELPASQIHISENTFVPTYKPGIDAFREFVQNNRIKCLYHFTDKANLLSIFEHGSLLSWHELTERQLFHKAGGNEKSRELDTRRGLQNYVRLSFTNNHPMQYVCQNDGRIDELVLIEIAPEVIYWEETLFSNTNATANYAKVGPNLAHLQLVNFEVIKRGSWATEREKYSIQAEVMVKEQIPCKYFLNLDYLEMIARMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD9</accession>
    <name>A0A1U9NJD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67917">
        <property type="protein sequence ID" value="AQT67917"/>
        <property type="gene ID" value="STSP2_01069"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01069"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="33660" checksum="37C5E655A227F3EB" modified="2017-06-07" version="1">MMKATGIKGNVDWNQRYQRALDRYEQIGAICPGLFTALTEELENWSDTLPQSHFAEGVYKPVNHWGLGAEQNEIRAITNELVLRGHDRLAACLQECFNSLRDSASALDEIYPKLDDEDEQAETRLVRQCRREAAHLSALLQRLRKKTFTANLKECPYSPAQLRDEIVKEDLGKSRPSEPGIAMSAGTCWSDISICFTNGHTVSIRVGRKSHTCNFAQMGMINRHTGEPNRQWETLRIFAESGGLLSWKNSSASPRLKKQKQQLSKKLRKFFQIADEPIVWGKDEKCYRCQFMIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH9</accession>
    <name>A0A1U9NJH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rafA_2</name>
        <name evidence="7" type="ORF">STSP2_01237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01237"/>
    <dbReference type="EnsemblBacteria" id="AQT68082">
        <property type="protein sequence ID" value="AQT68082"/>
        <property type="gene ID" value="STSP2_01237"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01237"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527454" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="866" mass="96978" checksum="F4F2E75AC1533CDE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK7</accession>
    <name>A0A1U9NJK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68112">
        <property type="protein sequence ID" value="AQT68112"/>
        <property type="gene ID" value="STSP2_01267"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01267"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120686" evidence="1">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="23144" checksum="CD0DE7A9FEE91F55" modified="2017-06-07" version="1" precursor="true">MSRMFKLNLAVLMAVLVSSLTFSYVGVDNKGTWPKSWPEELESLRDQSRTVDVLHGIKEKVYEIPFTDADQFARAWPHILKVKTPGAPLILEKAPSMYCVSGTCCSAGARILAPSNLYVGELTAGPPWPENLKTPKGSLPEYVIHEEGKWIPADPNRQKGDYHSRLRARTDIVLIVDGDILDLNKIPLPPHTPIIDNRFKDQSKDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP6</accession>
    <name>A0A1U9NJP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4435 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68035">
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        <property type="gene ID" value="STSP2_01189"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01189"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029492">
        <property type="entry name" value="DUF4435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14491">
        <property type="entry name" value="DUF4435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4435" evidence="1">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="296" mass="34174" checksum="1DEF526071D2B082" modified="2017-06-07" version="1">MVYRRTKSGEENTYLFYGTEITVYVEGGPETKYQDASESEFYSYGDDIRFWEGLFDHFAPGVKCHCKAIGSKVAVREIAEDIAAGDRKRVIAAMDRDFDDLTSQLINSHNVLYTYGYSWENDCCNPSSLVEAYRSYASAANRLADATKKDILKVLQACQKLLARAVRADAVLRLNSHSFFDRDRPCRYIGKGAGDYPTIRVSEIRKRFKEVRREHLRPVRSSQKLELITFRDCFGHLIGHFYCRLLSVLLKKVNKPSIPNDFAFAMIVEKFLVNIANDEHKDIYNHYKKQFRKIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ3</accession>
    <name>A0A1U9NJQ3_9BACT</name>
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        <submittedName>
            <fullName evidence="2">B12-binding domain/radical SAM domain protein, family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01191"/>
    <dbReference type="EnsemblBacteria" id="AQT68037">
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        <property type="gene ID" value="STSP2_01191"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01191"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051536">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
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        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="192"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="440" mass="49953" checksum="CBDCC67144BD6DA9" modified="2017-06-07" version="1">MEKMKQTILLVNPPIYDFAAYDFWLKPLGMLTTAGHCKPFAHIDLFDYLDRLSPDMPPPKRPPKNRFRKGPFHAQHIPRPPEFAHIPRYFRRFGIPRRVFQDYLRSRPQYDFVLIQTTMTYWYPGLKEVIEDVRTLQPRATIVLGGFYATLLPDHARSLGADLIIEADNHKPLYDKLLATPADYHPPYWQAYPNLRTAAMTLTTGCPYKCTYCAIGQMNLPFAHRPIDHCIQDLQLLLSKGVTDIAFYDDALLYKPEKILKPFLEYVIGNIPQGKINFHTPNAMHARYITPEIAQLMVRAGFRTFYLGFESASPTFQQNTGSKVVSADLAAAVTHLKNAGADAQTITAYELIGHPNTDLQHLESSIRFANSLGIKVMLSDFSPIPNTPDGQLCSEYIDLSEPLNHNKTAFPITLLGHDKVSYYKNLCKSLNRSLPAPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT4</accession>
    <name>A0A1U9NJT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68181">
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        <property type="gene ID" value="STSP2_01336"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01336"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27236" checksum="55A3E77113582DF6" modified="2017-06-07" version="1">MKTKILNKLKLNNGSLSRVMVLLTIAVVAVTAGKVIAYMQMVEQVPSEKEKSVDLTSKMDTETLVKPYKELAGELKKRDIFMPPAPKPKPQPPVCQGIIGDGVLVNGKLYKKGDNVQGAEILAVGPSSVRIKWQDKEMDLAPFLAKIEEQQGQQNNQKSAGRPSGRQQPVAQENQPQPQSQPQPQNEPQQRPQMGRGGFGPGMRMSQEQRERMRERWRQMSEEEREEMRNRMRGRRRPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV9</accession>
    <name>A0A1U9NJV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptide chemoreceptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tap_1</name>
        <name evidence="5" type="ORF">STSP2_01022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01022"/>
    <dbReference type="EnsemblBacteria" id="AQT67870">
        <property type="protein sequence ID" value="AQT67870"/>
        <property type="gene ID" value="STSP2_01022"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01022"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032255">
        <property type="entry name" value="HBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01358">
        <property type="entry name" value="HBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="344"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="655" mass="70426" checksum="D059FC282BAF234B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW9</accession>
    <name>A0A1U9NJW9_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="primary">cocE</name>
        <name evidence="2" type="ORF">STSP2_01377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.84" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
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    <dbReference type="EnsemblBacteria" id="AQT68221">
        <property type="protein sequence ID" value="AQT68221"/>
        <property type="gene ID" value="STSP2_01377"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01377"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="291"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="671" mass="76790" checksum="F30097826B9095B1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ4</accession>
    <name>A0A1U9NJZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Swarming motility protein SwrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">swrC</name>
        <name evidence="2" type="ORF">STSP2_01052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67900">
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        <property type="gene ID" value="STSP2_01052"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01052"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
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        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111334" checksum="DBC8F0D121B266B5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK03</accession>
    <name>A0A1U9NK03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase StkP</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">stkP</name>
        <name evidence="5" type="ORF">STSP2_01300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68145">
        <property type="protein sequence ID" value="AQT68145"/>
        <property type="gene ID" value="STSP2_01300"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DZR"/>
    </dbReference>
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        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="428" mass="48916" checksum="4A458DB68784F15F" modified="2017-06-07" version="1">MHQQLSLLKGRQLGKYRLVRKLGQGGYCEVWKARDTIEGIDVALKIPQPDEAGKRDNETILREVRLVAQLRHPNIMPLKNADIIRDHAILATEISAKTLFDCPKPMAPRRLITIATQVLNGLACAHRKKIIHCDVTPGNIFLLDNGTAALGDFGISVLVKRKMVTTDDIGTPGYFAPEQAYGKPSYSSDCFSLALVIYEYLTGHLPAWPFHWPPKHFDRLKKRTSVRFTQFVKKSLAIEPANRFANATEMLNAMNQALPKSLAADTAPSLPQKHDWKQHRRAAFKKRYKNIFPALHRCVNCTEPVAEPMLVCPWCGTDKNRFENLTPLPYYCPRCHKGLAPSWKYCPYCYGPSFDLDPTEKSPPVHYHDKCTHCGRKTARFMKYCPACRRKIRKPWHAWPFPHTCPSCKSSVDKNFWTHCPWCKSHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK31</accession>
    <name>A0A1U9NK31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67940">
        <property type="protein sequence ID" value="AQT67940"/>
        <property type="gene ID" value="STSP2_01092"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01092"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12937" checksum="FF1B4C683EF8A6D2" modified="2017-06-07" version="1">MTDMLNQGLDWLGQMLTKHCSSQIIYRQDQIEVSINAVFAKTDLQLEDEHGISIRSFVWDFLIASAALGFEPQPGDTIVAEDKTFEVMNLSGDGCWRWTGPDRNMYRIHTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK37</accession>
    <name>A0A1U9NK37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67950">
        <property type="protein sequence ID" value="AQT67950"/>
        <property type="gene ID" value="STSP2_01102"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01102"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8460" checksum="EFDA9814F5F662F4" modified="2017-06-07" version="1">MAEGKMQNDWSHTSAVLAMMANVNRDPKKSRSFKPADFNPLENGSDKSQAIVIDESNIHLLKEAFTGRKGNFNGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK46</accession>
    <name>A0A1U9NK46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01038"/>
    <dbReference type="EnsemblBacteria" id="AQT67886">
        <property type="protein sequence ID" value="AQT67886"/>
        <property type="gene ID" value="STSP2_01038"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01038"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030183" evidence="1">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="54425" checksum="EC3926416EEC82D8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK66</accession>
    <name>A0A1U9NK66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylrebeccamycin-D-glucose O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.164</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rebM_1</name>
        <name evidence="2" type="ORF">STSP2_01058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.164" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67906">
        <property type="protein sequence ID" value="AQT67906"/>
        <property type="gene ID" value="STSP2_01058"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01058"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102082">
        <property type="term" value="F:demethylrebeccamycin--D-glucose O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="28011" checksum="138B3F29807865AA" modified="2017-06-07" version="1">MKIHRETDCQLSPEQYAHLRATSPGLCRRILERLQLPAGGILCDVGCGPGLHTVVLAEMYRGSVIGIDKDAARILHAKAGLSSCTWKVADSVDLPLASKSIDGLTVMFAFHRFSQPHKALYEFARVLRSGSRLAIVTLSHQQLKSRPELNGFPEALLAELARFPRINQIETILMDVGYSDIQTEQYKEVVSYSGYSFLEWVRMRPYSSHRFMPKRRFCECMKRLSDQFSTLPQVEIANEATIITAEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE6</accession>
    <name>A0A1U9NKE6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsU</name>
        <name evidence="7" type="ORF">STSP2_01562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01562"/>
    <dbReference type="EnsemblBacteria" id="AQT68402">
        <property type="protein sequence ID" value="AQT68402"/>
        <property type="gene ID" value="STSP2_01562"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01562"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7718" checksum="707084D90C8B24E6" modified="2017-06-07" version="1">MIKVRARAGESVQAMVKRFKKMCEKEGLIRDMKRNSYYEKPSEKNRRRRRKAQRMAQMGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG2</accession>
    <name>A0A1U9NKG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliA_1</name>
        <name evidence="8" type="ORF">STSP2_01571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01571"/>
    <dbReference type="EnsemblBacteria" id="AQT68411">
        <property type="protein sequence ID" value="AQT68411"/>
        <property type="gene ID" value="STSP2_01571"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01571"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29863" checksum="8FC85D2F2D7CF381" modified="2017-06-07" version="1">MKTAQAQDIGQIWQSFFETHDEQYRNLLMENYLRIVKYTADRIYAKLPDKVEVDDLVSAGIFGLMDAIDAFDPERGVKFETYCTPRIRGAILDELRSMDWVPRLVRARAHQLEGALSTLEAHLGRMPTETEIANELQLDMTEFKRLQRDAYATGVVSLSTNFSDSEGDKDVREIDVIKDKKSSDPLVEAQKRDLKNLLTKGLTRAERLIIILYYYEEMTMKEIGATLDLSESRVSQMHSSIIARLKAQMNTRKKEFSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP2</accession>
    <name>A0A1U9NKP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68501">
        <property type="protein sequence ID" value="AQT68501"/>
        <property type="gene ID" value="STSP2_01666"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01666"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3238" checksum="B7210757108A4957" modified="2017-06-07" version="1">MKSSFQKAYLMDFAGKKSGLVSLSADQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS3</accession>
    <name>A0A1U9NKS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysG</name>
        <name evidence="7" type="ORF">STSP2_01674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01674"/>
    <dbReference type="EnsemblBacteria" id="AQT68509">
        <property type="protein sequence ID" value="AQT68509"/>
        <property type="gene ID" value="STSP2_01674"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01674"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26836" checksum="17E0B3E4B90B31BD" modified="2017-06-07" version="1">MNLKLLPLTSVATLNFSENHWLARLAAVILTAMPTYPIYLNLCNKKALVVGAGQVAARKAQALSRAGASILVVAREYSAEFNDICKHIQLERIEGDYSPEYLDDATLAIAATDDSELNTRIYNDCRARNVLCNVVDVPHLCDFYVPAVINHGDLTISIGTSGKCPAYAGRLRRKLESIITPDHGAFLEVLESARQKVITSDLTAQQRKKLLHHLAADTSFTLFRQQGADAWLKWADQQISASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW1</accession>
    <name>A0A1U9NKW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01716"/>
    <dbReference type="EnsemblBacteria" id="AQT68549">
        <property type="protein sequence ID" value="AQT68549"/>
        <property type="gene ID" value="STSP2_01716"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01716"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32131" checksum="02F12EE60D04F855" modified="2017-06-07" version="1">MSHDRTIKRTGNEGFTLIELLVVIAVISMLMAVMLPALGAVKQKAKGLVCMSKLKQMGIAFWAYAADNNDYSIPTYDPDDNTYWWGQIKSDGIDHKAGFLYPYMQSSLEEGGIYECPSQPFGSYELQAKPADESVSPDWITSTYGYNGYYLAPPSSPWQNIHDKPWQRLAGVSNSGKVIAFADSMLDWNIRPDQAELSNNAMIDPPMILSADKTGWQKNPCPTTSFRHDDRTSVVFVDGHCETKPVEDGQYTSPSAKIGSITATNGPYYVPDYESWPTGERRRRRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX8</accession>
    <name>A0A1U9NKX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltooligosyl trehalose synthase</fullName>
            <ecNumber evidence="2">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treY</name>
        <name evidence="2" type="ORF">STSP2_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.15" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01621"/>
    <dbReference type="EnsemblBacteria" id="AQT68457">
        <property type="protein sequence ID" value="AQT68457"/>
        <property type="gene ID" value="STSP2_01621"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01621"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="8"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="905" mass="102952" checksum="2240C68753758B9C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL05</accession>
    <name>A0A1U9NL05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68404">
        <property type="protein sequence ID" value="AQT68404"/>
        <property type="gene ID" value="STSP2_01564"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01564"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21293" checksum="174BC4E3278C9094" modified="2017-06-07" version="1">MTRTQILAKALLAVLGVHAFFYLFFKAFDYIRLASRYSASAVIASAILLLLFWLILVYLVFRNNRLAAILPGPAPDDPPATTLFTVLTFRTAFVAYGLILIGKNARHFLGILSFLFPSRIRDYINQIITGSTDLADVLTIYTLYPLGYLVLFILSIYFITGAPHLVRFYTRQIASFASQKPKPSGVSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA9</accession>
    <name>A0A1U9NLA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68723">
        <property type="protein sequence ID" value="AQT68723"/>
        <property type="gene ID" value="STSP2_01895"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01895"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="38025" checksum="85A4C5CC56F1374D" modified="2017-06-07" version="1">MNPTKEKLKIAARLQQALITGRCNRLIETSHRTQRFADMAAHIMKNSHKLELAAVRGWHGAAKKCLSRIDRLCLEINYWISANKETLAPPRTKTPTIRQLIEELDQIEADCGGFRFDPPRDTLSVTTAPITLEGVYLGPFEISLYIEGLTSSDNRSKYYVTALDPHPAASESAVTHPHISNELVCEGDGTVPIRKALEQGRFADFFSMVESILKVYNPESPYIPIEDWEGISCYECGFITDPDHTLYCEFCGYDFCQGCVMFCQCCRQITACISCQDECIDCGDTICPDCTRTCSECGDNFCVKCIGEDICRDCLAERSNENGQEKQNDSQDQITIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI4</accession>
    <name>A0A1U9NLI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01974</name>
        <name evidence="9" type="ORF">STSP2_01975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68801">
        <property type="protein sequence ID" value="AQT68801"/>
        <property type="gene ID" value="STSP2_01974"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68802">
        <property type="protein sequence ID" value="AQT68802"/>
        <property type="gene ID" value="STSP2_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01974"/>
    <dbReference type="KEGG" id="alus:STSP2_01975"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="137"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="33115" checksum="620716E379982641" modified="2017-06-07" version="1">MMQAGLFDWQTRFEQLDNSGDPLVKLNEIVDWEQFRKTLEVVRDKKRKSNAGRKPFDVILMFKILILDSLYNISDDQLEFQIRDRISFMRFLGLGIGDRVPDAKTIWLFREQLTEAGLVENLFTQFDEFLRKNGFSAKKGQIVDASIVAVPKQRNTRDENKSIKNGEVPENWSDTKKRQKDTDARWVQKNGVNYYGYKNHIDIDVKHKFIRSCEVTPASVHDSNVFEDLLDANNSSKDVWADSAYGSTEKRDNIKEEGYRGQIQRKGCRYKKLTQRQIEANGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL3</accession>
    <name>A0A1U9NLL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01999"/>
    <dbReference type="EnsemblBacteria" id="AQT68823">
        <property type="protein sequence ID" value="AQT68823"/>
        <property type="gene ID" value="STSP2_01999"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01999"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387302" evidence="1">
        <location>
            <begin position="22"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="294"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="658" mass="71594" checksum="48FC73078F40DE7D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL9</accession>
    <name>A0A1U9NLL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01985"/>
    <dbReference type="EnsemblBacteria" id="AQT68809">
        <property type="protein sequence ID" value="AQT68809"/>
        <property type="gene ID" value="STSP2_01985"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01985"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504940" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="527" mass="56749" checksum="70C4AC0D38F990F1" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS0</accession>
    <name>A0A1U9NLS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">STSP2_02049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02049"/>
    <dbReference type="EnsemblBacteria" id="AQT68873">
        <property type="protein sequence ID" value="AQT68873"/>
        <property type="gene ID" value="STSP2_02049"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02049"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15402" checksum="AA1B3BE91CF42090" modified="2017-06-07" version="1">MAADKKIEEGLSFQPKFDANGLITAISQDADSGQVLMVAYMNDEALKLTLETGNAVFFSRSRQKLWKKGEQSGHMQKVQQILVDCDQDCLILKVKVDQGQCHVGYQSCFYRAVKPGTTNELEFVAEKVYDPNEAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW2</accession>
    <name>A0A1U9NLW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01640"/>
    <dbReference type="EnsemblBacteria" id="AQT68476">
        <property type="protein sequence ID" value="AQT68476"/>
        <property type="gene ID" value="STSP2_01640"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01640"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="514" mass="57365" checksum="5F5DD1952D2F2079" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX6</accession>
    <name>A0A1U9NLX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5009 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01910"/>
    <dbReference type="EnsemblBacteria" id="AQT68738">
        <property type="protein sequence ID" value="AQT68738"/>
        <property type="gene ID" value="STSP2_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01910"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032176">
        <property type="entry name" value="DUF5009"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16401">
        <property type="entry name" value="DUF5009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5009" evidence="2">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="379" mass="41878" checksum="A2859EFDB0246418" modified="2017-06-07" version="1">MSQTQEAQTINVKSKRLVSLDALRGFDMFWIVGGDRLLKALLLVMGLESAHAAVSKQFIHAPWHGFTAYDLIFPLFLFISGVTMPFSLGKQIQTGTPRSKIYLKIFKRGLLLVLLGCIYNGMLSLDFANLRYPSVLGFIGLSWMFAALIFVNTTWKSQLGWTAGLLLVYWGAMTFVPVPGHGAGDLSMEGNLVGYIDRLILPGKLYRGVFDPQGTFSLVTGTGTALIGALAGTMLVGKNKLSEKWLTVGLLVLAGIGCVLLGLLWNIVFPINKEMWTSSFTVFTAGLSFLLLAVFYSIIDVIGFSRWAFPFILIGLNAITIYLGAHHVINFGHTTNFFFAGLVNKVGGNWGHFIWAFGFVLIELTFLYVLYKKKLFLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX9</accession>
    <name>A0A1U9NLX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="4">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabF_2</name>
        <name evidence="4" type="ORF">STSP2_02011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02011"/>
    <dbReference type="EnsemblBacteria" id="AQT68835">
        <property type="protein sequence ID" value="AQT68835"/>
        <property type="gene ID" value="STSP2_02011"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02011"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="440" mass="46029" checksum="D350E568B39EB472" modified="2017-06-07" version="1">MSKRRIAITGVGATTPLGLTAGEMWEGLLEGRSGIDKIQSFDPAGFPCRIAGETPAFKVRKHVPKTYRKATKLMSRDIELSILAANDAIETSGLVTKAAGEGEPTIDPERFAINMGAGLISCDLEELAPCVAASLTDGEFDLKKWGTEGLNYMTPLWLLKYLPNMLPCHVGIIHDMQGPSNTITCGEVSSHVAITEAAQVIARGDADAAMAGGCEAKVNPIVLLRQCLLKRATSDHNGTPDEACRPFDAEAKGSVFGEAAGLVVLEELEGAKSRGAKIYAEIAGAGASNSLASSYEHSETDGKGIEIAIRKATKEAGIDAGQIDLVVPHGTGIPADDAAEAKAISRVLGERTAEVPVWPIKSMTSNAGAGAGSLDVIATAMAISEGKIGAAKNFEQPFDGCELNISKQVQEVNVRYALCCGYTFGGQTAALILKNTNGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM01</accession>
    <name>A0A1U9NM01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein YajL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yajL</name>
        <name evidence="2" type="ORF">STSP2_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02138"/>
    <dbReference type="EnsemblBacteria" id="AQT68961">
        <property type="protein sequence ID" value="AQT68961"/>
        <property type="gene ID" value="STSP2_02138"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02138"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19461" checksum="337CFA88619685E9" modified="2017-06-07" version="1">MSKKVLIAIADGSEEIEAVTIIDTLRRAGAEVTVAATGHKKEIKASRGVQMTADVLVDDVKGEPFDLIVLPGGMPGAERLANSEGLKAMLDIQARDGKLYAGICAAPAVVLSVRGLLKGKRATCYPAFEKQMDCEKFVDEPVVVDGNCVTSQGPGTALAFSVELVNQLFGGDKAKEIADAMLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM07</accession>
    <name>A0A1U9NM07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68992">
        <property type="protein sequence ID" value="AQT68992"/>
        <property type="gene ID" value="STSP2_02170"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02170"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15924" checksum="E9FEE6BCCAEC688E" modified="2017-06-07" version="1">MKDNVTIIAVQRDVDELESLRKGLHRAGIANEVKHFGEISKAENFFDSLGDSEGAHPGACYLLLVDAEGANGEAEDFIAKLKQSAALKRMPILVLSTEDDEAATEKWHSMGCSIYLSKPSSPADLIDAIHKLGLFLGTVEIPQVGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM44</accession>
    <name>A0A1U9NM44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EIIABC-Fru</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fruA_3</name>
        <name evidence="2" type="ORF">STSP2_02053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02053"/>
    <dbReference type="EnsemblBacteria" id="AQT68877">
        <property type="protein sequence ID" value="AQT68877"/>
        <property type="gene ID" value="STSP2_02053"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02053"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16824" checksum="8895C21A0C59E0D1" modified="2017-06-07" version="1">MKLKDFICFDAIVPELDSNDRDAVISELVNSLEKAGKTQGIPVDELIEAVIKRENEASTGIGKGIAVPHVKHSGIKKLVGTIGCSSAGVDFSALDKQPTYSVMLLLSPAEDPDRHLQAMECIFKNLQNDDFRKFLRQAQTAEKIKEVVEDVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM51</accession>
    <name>A0A1U9NM51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
            <ecNumber evidence="2">2.7.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbsK</name>
        <name evidence="2" type="ORF">STSP2_02167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02167"/>
    <dbReference type="EnsemblBacteria" id="AQT68989">
        <property type="protein sequence ID" value="AQT68989"/>
        <property type="gene ID" value="STSP2_02167"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02167"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="322" mass="34229" checksum="FD2E7FE96521CF1E" modified="2017-06-07" version="1">MRPRIPRIVVIGPSYVDMAIKCDTFPSAGESVEGTGFSYIPTGSGVVSAIEASLCDCDVNLISKVGDDCQGQTIRSYLEEKKVSTEFVYTAQAISTGAIVTMVNGTGENMSCVAEGANRSLQVDEIKAAPTEQLISSADACLIRTGVSREIGRAAIQLCKLYQTRVVLELPMETRDETELEFLDWPSDFYDVDVLIPDVSNGSLVSDPAVGIVHNLKFLGSGLVARGVKYVVIKMGHRGCCVVSRDGVDQIRGFSLEGVIEQGASGDAFAGALAASCGAGDQINDAARFAQAACELAGQKFSTPDSLPRKAEIIELLQSQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI1</accession>
    <name>A0A1U9NMI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas4-cas1</name>
        <name evidence="8" type="synonym">cas1</name>
        <name evidence="9" type="ORF">STSP2_01888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01888"/>
    <dbReference type="EnsemblBacteria" id="AQT68716">
        <property type="protein sequence ID" value="AQT68716"/>
        <property type="gene ID" value="STSP2_01888"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01888"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="38595" checksum="5B73FFA83372760D" modified="2017-06-07" version="1">MKQLLNTLFVTTQGAYLSKKGDTVVVNVEHKPVLRVPVHNIGSIICFGNVMCSPFLMGLCGKQNVTLSFLTENGRFLARVHGPVNGNVLLRKEQFRRSDDLNASARIAQTMVTAKIANSRIVLLRHLRDSCSIEGVNIIRNAVENMMEHLQTLQDECSLDTVRGVEGMAANAYFDCFDHLMTANKDAFVFATRSRRPPLDNVNALLSFVYTLLVRDVESALESAGLDPAVGFLHRDRPGRPSLALDVMEELRAYLADRFVLSLINRQQVRPSGFTRTESGAVMMDDQTRKALLVAWQKRKQEEIMHPFLKEKISLGLLPHAQAMLLARYLRGELEGYPPFLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ2</accession>
    <name>A0A1U9NMJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68954">
        <property type="protein sequence ID" value="AQT68954"/>
        <property type="gene ID" value="STSP2_02131"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02131"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="386" mass="42733" checksum="BA274D25D9511337" modified="2017-06-07" version="1">MDSRGDRKNAEDRDIAQSRADIAKAREMIRAMKAGRKAKRPDVDEPDTDDKPAKKKGIRSFEDIRHDSGVIDAKWEDSDEQNKKPSAEFDQNDSPDSDYTPANSTPEIQPEKADTDSTDENTSSVEEKQLTIENEAEHEEADLRAAFGNEHKDNSQSASSGIDEDVAALEKELRSLGFADTDDDQKSDDADKSSREAIADIPSDSAETAEGDVATAESTLSNADKQDSVTTDDKTATDQQQMRKSTPDTQRTVPKFNLAEQILAEQRKKAGAKRIAPTSRRPASTNKGRGTLGDVIARTKKDTTGWPHKSQGKPQRPAREAPQPQKDIPAPRMKRQTSAPVLAIVREKSSLSPMQQKIIADIVERDIRRMCKDNAKDAMWTGYNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ6</accession>
    <name>A0A1U9NMQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02421"/>
    <dbReference type="EnsemblBacteria" id="AQT69232">
        <property type="protein sequence ID" value="AQT69232"/>
        <property type="gene ID" value="STSP2_02421"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02421"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="17115" checksum="44B73C08AE6EBDA1" modified="2017-06-07" version="1">MPKTSTEIKALQDAVTREVEAYLFYKNLAARTRDEDSKDIFEMLAQEEVRHKENLELELMKRGCTVQDQGEPDWPGRIAGEEMGKFDLDYIDALRIAIQKEDSSVRTYIEMAASTKDSKALDIYLGLAEEEMRHKLQFQAAYNRAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR8</accession>
    <name>A0A1U9NMR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69199">
        <property type="protein sequence ID" value="AQT69199"/>
        <property type="gene ID" value="STSP2_02386"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02386"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="15686" checksum="78FBBA7CD4E4DD66" modified="2017-06-07" version="1">MLFQNLIPMLKNSLSGGDKIMKKKCPECERVLELNDKNFRFFNGYWRRKCRQCQNAHKRKVYQNTKHTRPRLTRHAAYKLAKEKRIAVYIERFEQEESILRRYRLNLNSPADMVDEVLEVERRLKRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV5</accession>
    <name>A0A1U9NMV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glnB</name>
        <name evidence="2" type="ORF">STSP2_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02432"/>
    <dbReference type="EnsemblBacteria" id="AQT69243">
        <property type="protein sequence ID" value="AQT69243"/>
        <property type="gene ID" value="STSP2_02432"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02432"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12514" checksum="919EC6798EFDA48C" modified="2017-06-07" version="1">MKLIIAYIQPHKLEEVKQELAKAEVAKMSVTNSLGCGAQQGYHESYRGVEFDVNLLKKVRLEIAVSQPYVEKTIDAIIKGAKTGEIGDGKIFILPLEDCIRVRTGERGREAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN05</accession>
    <name>A0A1U9NN05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02168"/>
    <dbReference type="EnsemblBacteria" id="AQT68990">
        <property type="protein sequence ID" value="AQT68990"/>
        <property type="gene ID" value="STSP2_02168"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02168"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="308"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="394" mass="44237" checksum="B80196BF06B8A8A1" modified="2017-06-07" version="1">MENNELKAFTKQNTQVRAGEILRALCDRREIRLFRCTVIGELDANKLLDPEGEYNCDDLSVDRPAFHACLRFEQKIHFNSCKFLENVCFASPWDTPKALKAVFAGDVVFNSSIFCGQALFANATFKQLAGFDGCEFQKVTAFRNSLFESRAMFRTAHFAGYGLFSGARFGGDSRFTNTCFGKGANFSKTKFCTAVDFAGVYAESRAIPIFEDVEFTRKGRGDDETFWRFIKQASQEAGYYRMAGECFYKERCAHLWKKFRGPDDEVERGKRIAVRLLRGLQILPELVFGRLLFGYGERPIRVLIAGAIVIIACGIFYESPLADLSGRLATESGHYSLVDGLYFSVTTFTTVGFGDIHPVETHLLTRFVVMLEAMTGAGLTALFIVALSKRYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN17</accession>
    <name>A0A1U9NN17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atsA_18</name>
        <name evidence="3" type="ORF">STSP2_02492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69303">
        <property type="protein sequence ID" value="AQT69303"/>
        <property type="gene ID" value="STSP2_02492"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02492"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="529" mass="59914" checksum="5077022E9678F532" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN59</accession>
    <name>A0A1U9NN59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">htpX</name>
        <name evidence="14" type="ORF">STSP2_02522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69333">
        <property type="protein sequence ID" value="AQT69333"/>
        <property type="gene ID" value="STSP2_02522"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02522"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="80"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT69333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="45263" checksum="E39EB6FF84415D1D" modified="2017-06-07" version="1">MWEQIRANKRNSIILLGTMAVVLMGLGYVIGMLLAGPKGGYYGVAAASGLWVVLTIVSFSSGDQILLSASKAKPVTPEVHPQLWNVVEEMTIAASLPKMPKVYIIPDPAPNAFATGRSPKSASVAVTAGLLGKLNRDELQGVVAHEVSHILHRDILFVTLAGIMLGTIVILSQLLLRSTFYGAFAGGRRYSSRSNGNAQGQLLMIVIAILAAILAPVFANILYFALSRRREYLADAGAARLTRYPAGLASALEKISSNAQPVEAVNKVTASMYISNPLSAKKRGSLFSTHPPIEERVKILRTMSRGASFKDYSDAYSQTVGSGDGMPASLREDKEQVGLREASEAVGAAAGMGGAAGAATAAAARSAEEEPAKTAKEQHRQIGDLIRIANGFAILTCGCGLKMKIPPNYNRQAVKCPRCGRKSALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN74</accession>
    <name>A0A1U9NN74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactokinase</fullName>
            <ecNumber evidence="5">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">galK</name>
        <name evidence="5" type="ORF">STSP2_02550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.6" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02550"/>
    <dbReference type="EnsemblBacteria" id="AQT69361">
        <property type="protein sequence ID" value="AQT69361"/>
        <property type="gene ID" value="STSP2_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02550"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="4">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="45274" checksum="B9A378FC37369E2A" modified="2017-06-07" version="1">MVTHDKESASVLNGMAKRNGLDIVGGKIRRSSSRFCLGVEHGDYNGTELFGVGTDRFIWLGYKPNGTDKVRMFSGNFPDDGVVEFTLGDVPEPQSTPDSWARFPYGVSYILKREGYELTQGFDAVIYGNIPGGGMSRSASLSLNLILTMLEVNGIEMGDQLKIVDLAQAVENDYIGSPCGQLDQIMILFAKEGMGTHYNPADRSISYVPFGGDVDEFRIVGLDTGTDRPGLEKSTYKVRRTECDDFVKLLQAGGYEIESLADVKDEQLYGKIMEQFGESHADLCDRLTYIYKAQKRFYEMMEAWKKGNIKRVGEIFREDGIGLRDEYKISGPELETMCDVVRSVEGVLGERMLGGGDKGASGAIVKADAVDEMKKAVDVGYPRSRPDYADKYAVHSCKVVDGMKVMDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN79</accession>
    <name>A0A1U9NN79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase C</fullName>
            <ecNumber evidence="2">5.4.99.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluC</name>
        <name evidence="2" type="ORF">STSP2_02484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.24" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02484"/>
    <dbReference type="EnsemblBacteria" id="AQT69295">
        <property type="protein sequence ID" value="AQT69295"/>
        <property type="gene ID" value="STSP2_02484"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02484"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29290" checksum="398E391CE8E74AC3" modified="2017-06-07" version="1">MPKIIDIIHKDDELLIINKPAGFSVTKDRTGKPDIVALLRKQLGPDETILLVHRIDKPTSGIMLIARTKDAQRKYAGCFAKRKIEKTYLAIVSGVVPDDTGTIKRPIAPSKKQPGTVYVSPRRGKQAVTEYRLLADFGLAALVAANPITGRTHQIRIHFADIGCPLAIDPLYGSSNPLLLSDFKPKYRLPEGKTERPLIETLTLHAYQITLPADETHTKPRKFTAPLPKKFNAAIKMLTKHNPAGPDAFLNYSDFERITNSDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN97</accession>
    <name>A0A1U9NN97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69214">
        <property type="protein sequence ID" value="AQT69214"/>
        <property type="gene ID" value="STSP2_02402"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02402"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010714631" evidence="1">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="235" mass="25087" checksum="0E67DDFFD17C4A78" modified="2017-06-07" version="1" precursor="true">MKKVCVCLFAICLLFTASQVLAGPITIDADMSDWTGSGIVDLGTQAAPAEGESYTLKATADASNVYFGMDRSTTERYLDDIGWDTDSFFMAFDVDGVAGSGAISDGYGRVNFGGTYLPDFFIYFAGGPHWYETSSWNGSGMDWLGWTQDGAVYGNPGWGDDDEFALNPAAIGGEDDELRVWAWMTREGNGWVEAAWGFEAGDAPTAGDGLAVTVPEPATMALLGLGSLAVLRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB6</accession>
    <name>A0A1U9NNB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pimA</name>
        <name evidence="3" type="ORF">STSP2_02423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69234">
        <property type="protein sequence ID" value="AQT69234"/>
        <property type="gene ID" value="STSP2_02423"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02423"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="43048" checksum="BCF915EA900B3FBD" modified="2017-06-07" version="1">MQFTSKRIAVLSPVAWRTPPRQYGAWETVASNITEGLVRRGWDVTLFATADSVTSARLHAVVPHGYEEDPTLEPKVVEALHISELMENAHKFDLIHNNYDFMPLTYSRHISTPMLTTIHGFSSPKILDVYRKYKDLYYVSISDSDRDPHLPYLATVYNGIDLANLTFTPEPGDYLVWLGRIHPDKGTHLAVEVALRTDKKLKLAGIVQDREYFEEMVKPNVDGKQIEYIGPVGPLERDELFKEAFCLLHLNELPERFGLVMAEANAAGVPVIAYDRGSCREVISDGETGYLVGNVDQAVEAVGKVSKINRRACRKRVEENFSIKCMVSEYEKVYWRIFELERLKTRKSVIKPHMEKIQELKETAIETQTYRRTVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND6</accession>
    <name>A0A1U9NND6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69409">
        <property type="protein sequence ID" value="AQT69409"/>
        <property type="gene ID" value="STSP2_02598"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02598"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28832" checksum="CA4072783722C273" modified="2017-06-07" version="1">MQITSQRFAITGGRIAVLGTMIAVLAFCSSCGPDKDALARQRFERMASVMERQGFSEDDNSDGQAAEIPVHVEIVATNSENYAALESLWEEAETDDVTVYNAAQFRDSGLRVAVAGEGLGERLDEVKQNLHLYEGSDMVLLLTPGVSGYMPLGKGIYQASFVYDRTEYSPGTSSFENARRYLRLSAERTAGDKIRLRIVPAFDNLQSDKSGLDMNALSAQAVLESGESVLLAEKAEPRSPGTALLSYKGVEYRFRTVLVITPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG2</accession>
    <name>A0A1U9NNG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide core heptose(I) kinase RfaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69056">
        <property type="protein sequence ID" value="AQT69056"/>
        <property type="gene ID" value="STSP2_02241"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02241"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="20260" checksum="EBE214DC5904BF6D" modified="2017-06-07" version="1">MLAEHDLNAPPVVAVGELKLGPFVLENFTFTEAVNHAPDLYEHVQAFAKSSSHLERRSFIEQLGETIGRMHATNISHGDLRPGNVLARKTDDRWQFFFLDNERTRKYMRIPRKLILKNLVQINMLHSDVLSSTDRMRFFKAYLRSNPKLVPERKLIARKSAQRTAERLNKKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ2</accession>
    <name>A0A1U9NNJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4091 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02272"/>
    <dbReference type="EnsemblBacteria" id="AQT69086">
        <property type="protein sequence ID" value="AQT69086"/>
        <property type="gene ID" value="STSP2_02272"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02272"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="DUF4091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4091" evidence="1">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="481" mass="54618" checksum="FF61C3F0E694E03A" modified="2017-06-07" version="1">MVSKDGDSLGDGSLNANFVRYVLAAETLYPDILDPVERLNLAANTTRPVWVTMEVPRDAKPGHYSGKVAVKAAGNVRLDFTFKLEVLPLTLPAPKDWKFHLDLWQNPFAVARWHRVEPWSDEHFRLMEPYWRMLAEAGQKCLTVSLFHHPWGAQVYDGFEEMVTWTRKSDGTWEYDFSILDKYVAFAERVGLDDQINCYSMIPWTNSFRYIDAKSGDWKDVGAIAGNPAYEEIWGPFLKALEQHSKEKGWGGRLTIAIDERGEKQVLAATGILKKYAPSIQLSSASNHPPSDFTINDWSSTFGTSVDPNMVQERNSRGLKTTFYVCCNPTRPNTFTFSPPAESAWMGLYAAAQNRSGFLRWAYNSWNENPFYDTKYWPQVWAAGDCFMIYPGPRSSIRFERLREGIQDYEKIYILRKLAAKQLNDPRVKKAVKELDAALAVIDHQSVTNNTAASVQVKDVNVSILQLSRLVICPSSLVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ3</accession>
    <name>A0A1U9NNJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na(+)-translocating NADH-quinone reductase subunit B</fullName>
            <ecNumber evidence="11">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nqrB</name>
        <name evidence="11" type="ORF">STSP2_02682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02682"/>
    <dbReference type="EnsemblBacteria" id="AQT69491">
        <property type="protein sequence ID" value="AQT69491"/>
        <property type="gene ID" value="STSP2_02682"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02682"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33418" checksum="DBD8C129D375CE12" modified="2017-06-07" version="1">MRRVLIASIPPAIGAVYFFGWRSLVSLLVCCLTAFIVEHLFCRKRGQPVTEAAFVTAVLFSLVIPPHTPWHVQIIGVSFAIMFSKEVFGGFGKNFFNPALAGRCFVYISFPVALTAKWPPSAPLGGWGALGQWSTGTNTDAITSVTPMAAMKAGGDIPAAFDLFFGGISGSAGVTSAMLILIGGLYLYYTKTASRTTILSVVISYAVLNQILASAGVVNMDYAWTALLGGGFLFGAFYMATDPVSSPRTNWGRIYYGIIIALCTTVIRNFSIFNGGLMFSILLGNMFAPIIDYGVKSYGKRKKAKLAAAGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN8</accession>
    <name>A0A1U9NNN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enamine/imine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yabJ</name>
        <name evidence="2" type="ORF">STSP2_02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02419"/>
    <dbReference type="EnsemblBacteria" id="AQT69230">
        <property type="protein sequence ID" value="AQT69230"/>
        <property type="gene ID" value="STSP2_02419"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02419"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13729" checksum="4375A3F3DCAEAEED" modified="2017-06-07" version="1">MKKQRKIIKTTKAPQAIGPYSQALLVDDSLYISGQLGLDPSTGEIVGESVASQTHQVFKNIVAILGEADMALENVVQCQVFLSDMGDFAEVNAVYAEYFPENPPTRAAFEVSQLPAGGKVEILATAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT0</accession>
    <name>A0A1U9NNT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69549">
        <property type="protein sequence ID" value="AQT69549"/>
        <property type="gene ID" value="STSP2_02741"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02741"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030191" evidence="1">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30658" checksum="A9010E726B996AEC" modified="2017-06-07" version="1" precursor="true">MSIRGVCIVLCAVCMTGVCLAENGSDLENGVFELSVDERVALQEDRLVDIERLAKSRRESLRVKYDRAAASARRELGVFLERFEDRLEGLSMNDRDLLGLMVRNVADVSDVDRAMRADRYFASATGLLDERLTAGHLLVPVIEKYVSGDDVVDPFAVKLVARVADKIEQANQLEGKMVEAVSRVDAWEKRMKEQVQGIIRQIEAEPGEQRPSVINAIAYNEYGECVMMIGDELVREGDELRGVTVKSISTNKAEFEKNGRSWTQEVGEAANEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX9</accession>
    <name>A0A1U9NNX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02509"/>
    <dbReference type="EnsemblBacteria" id="AQT69320">
        <property type="protein sequence ID" value="AQT69320"/>
        <property type="gene ID" value="STSP2_02509"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02509"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6783" checksum="EA1AF9F96776EFBE" modified="2017-06-07" version="1">MAAEIGRYREDFAAGVLIVKEAGGVVSDFAGGEEGQPFETLATNGRIHEVMSLELMSVKRGQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY6</accession>
    <name>A0A1U9NNY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine/serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69662">
        <property type="protein sequence ID" value="AQT69662"/>
        <property type="gene ID" value="STSP2_02856"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02856"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010747560" evidence="2">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26820" checksum="C372C328C09DC06A" modified="2017-06-07" version="1" precursor="true">MTIQRIAILTLALALITTAGCDKQDEPQTKAVTGATTAYTNPDMPRETDTYEVLGYLKGIKGYVVKYNDDLYRGGEILARAGIEKLQSYGVKTIITITPSEVEQRLAKDLGINLIEMPFENGAIPAETFTRYIETITSDKGPYYIHCHGGNHRAGALCAAYRVHKQDWSWQKAAIEFGQLGGSLQKDHAMIQSIKQTPALAEDKPSQPQEPVDRQEKESLGDDKVSNGLRVEDPGKQHSAVCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP16</accession>
    <name>A0A1U9NP16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02445"/>
    <dbReference type="EnsemblBacteria" id="AQT69256">
        <property type="protein sequence ID" value="AQT69256"/>
        <property type="gene ID" value="STSP2_02445"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02445"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20785" checksum="2A9E3B1B7B90F260" modified="2017-06-07" version="1">MAETSGTNTKGSGPDAGKFVKLLTANYYRINAFILSMVPNAADAEDMMQETSEIMWQKFDEFEEGTDFAAWGVTIAKFRILNFRKSKQNQTAQLSEEALRLIESETDSMSEELDARLDALRACLSRLDEKDRQFIKLRYSPGATARSVAEVIGTSVHRVYRSVARINSMLLRCIRRRLTTEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB5</accession>
    <name>A0A1U9NPB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69749">
        <property type="protein sequence ID" value="AQT69749"/>
        <property type="gene ID" value="STSP2_02946"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02946"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527461" evidence="1">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="37328" checksum="FBD000DCE424BB53" modified="2017-06-07" version="1" precursor="true">MRKNQIWLTMAALLTLTPAIFAELVTHTEFQAVKSDGTSDFTGPETVTLEGIVLNSPEQLWDVSASAPAYMGGQWEMYIQGRGTDHAGTAVWLGQKYGNLGWVPPTGSYSDSEWLAELWRVNHDPNTAYTFQPGDLVRVTGKHLFYNGKRNINEQHDNDPAKDFTVELIQPAVGMPQPEPVSLNELKDASDDFIFDPTRQTGCEYYQGRYIRINDVSFAPDQTWGQGQTVTITDNHGRTFPVLLGRGPGIRPDSNNLADVFDVIGIMDQSCQAPHTAGYQLIVCNYDGNGLVLGDRGFRRGTLRSDANMDAQINLKDLAILANEWLEQVDGLVWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD5</accession>
    <name>A0A1U9NPD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02661"/>
    <dbReference type="EnsemblBacteria" id="AQT69470">
        <property type="protein sequence ID" value="AQT69470"/>
        <property type="gene ID" value="STSP2_02661"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02661"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26121" checksum="EFC64244893DBED9" modified="2017-06-07" version="1">MAKREIVKIDESKCNGCGDCVTACAENAIEIIDGKAKLVSEIYCDGLGACLGHCPMDAISIEERDAEEFDEEATNERIKAQENAKKRPSGGGCPGMMAQMFQGKRGDSEQRDGDTSSQLAQWPVQLALVSPNAEYFKNSDLVLAADCVAFAMGNFHSEILKDHSLAIACPKLDNTGPYVDKLAEIIRQNDLNSLSVLHMQVPCCSGLTRLAKQAVEASGKDMKFDDVTVSLHGEVLERTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH7</accession>
    <name>A0A1U9NPH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplX</name>
        <name evidence="6" type="ORF">STSP2_03040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03040"/>
    <dbReference type="EnsemblBacteria" id="AQT69842">
        <property type="protein sequence ID" value="AQT69842"/>
        <property type="gene ID" value="STSP2_03040"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03040"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12450" checksum="4EBCEB5C661A9FC5" modified="2017-06-07" version="1">MARHIRKGDSVEIIAGEHKGQVGKVLKVIPEKDRVIVEGHNLAYKHVRPSQRHPQGGRIRVEQPIHISNVLPVDPKTNKGTRVRFEVGSKGEKKRVSVAGNEIGAVGKSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH8</accession>
    <name>A0A1U9NPH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vi polysaccharide export protein VexA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02892"/>
    <dbReference type="EnsemblBacteria" id="AQT69697">
        <property type="protein sequence ID" value="AQT69697"/>
        <property type="gene ID" value="STSP2_02892"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02892"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="520" mass="57894" checksum="B70C1979464C6743" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK3</accession>
    <name>A0A1U9NPK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ORF">STSP2_02913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02913"/>
    <dbReference type="EnsemblBacteria" id="AQT69717">
        <property type="protein sequence ID" value="AQT69717"/>
        <property type="gene ID" value="STSP2_02913"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02913"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="697"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="914"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="601"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="977" mass="111381" checksum="8677DB4E7813C977" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN3</accession>
    <name>A0A1U9NPN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69869">
        <property type="protein sequence ID" value="AQT69869"/>
        <property type="gene ID" value="STSP2_03069"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03069"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="53" mass="6406" checksum="FCD3D3FCCE599B82" modified="2017-06-07" version="1">MNKLHALKHLSGGDYVHTPKWWKDHVLYDQRYWWGEWILFWIALLVTVLVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS6</accession>
    <name>A0A1U9NPS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase family 109 protein 1</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69516">
        <property type="protein sequence ID" value="AQT69516"/>
        <property type="gene ID" value="STSP2_02707"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02707"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="460" mass="51319" checksum="31BED68B3757CE0B" modified="2017-06-07" version="1">MARSINRRDFLRSSAVTGAGAVLGGIALGGCSGAPMLTTKPRVLTTEPKDEIRIGFVGIGNMGSGHVRRLMHIPGSKIAAVCDIRPSRTKWAVEQAKSAGLEVPAVYGKDETDFVRMCENEDLDLVYNAAPWEWHTPICLAAMENGSHAASEVNIALSIEDCWKLVETAEKTKKHCVMMENCCYDKAEMAVMNMVGQKLFGDLVHGECGYLHDLRGLLISDTYYQGQWRWKEQTTRDGNLYPTHGIGPMAWCMDINRGDTFDYMVSVSSRALGLHQYVVEKLGADHPMAKTDVACGDVNIALIRTKKGKTIICKHDTHLPRPYSRDFLVQGTKGIMRKYPKSRVHIEGKSKGHGWEDFGSYLKEYEHPVWKATQERIAKAGSGGMGHGGMDYIEDYRLIQALRRGISPDIDVYDSVLWSSVIPVSEESVRKQGEPVKFPDFTRGMWKKERKLGIVEYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW6</accession>
    <name>A0A1U9NPW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69949">
        <property type="protein sequence ID" value="AQT69949"/>
        <property type="gene ID" value="STSP2_03149"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03149"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6829" checksum="CB1C35CC3420CF36" modified="2017-06-07" version="1">MKWYLKLLGSTLLFLAGYGVYALICKFTPWQFDNQNAYILGLIFTCGHWYEWKGGEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ13</accession>
    <name>A0A1U9NQ13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69700">
        <property type="protein sequence ID" value="AQT69700"/>
        <property type="gene ID" value="STSP2_02895"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02895"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1582"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1601" mass="179586" checksum="FC1EBC4FEC3411A1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ47</accession>
    <name>A0A1U9NQ47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">STSP2_03052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03052"/>
    <dbReference type="EnsemblBacteria" id="AQT69854">
        <property type="protein sequence ID" value="AQT69854"/>
        <property type="gene ID" value="STSP2_03052"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03052"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11925" checksum="5D605C4E1F4FCCA8" modified="2017-06-07" version="1">MATQTEKIRIRMEAYDAKSLDASAREIVDQARRTHARVSGPVPLPTRIERFTVLRSPHINKKAREQFEMRTHKRLIDIHEANARTVEALNRLVVPAGVFVKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI3</accession>
    <name>A0A1U9NQI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">STSP2_03398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03398"/>
    <dbReference type="EnsemblBacteria" id="AQT70193">
        <property type="protein sequence ID" value="AQT70193"/>
        <property type="gene ID" value="STSP2_03398"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03398"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="147"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27636" checksum="8E1B192B4E1C3E2D" modified="2017-06-07" version="1">MAKRNVKLVIQYDGSAYHGWAKQPGAATVQDTCQRAIKKLVGEDVRVHLVGASRTDAGVSALGQVANMKIDTVVPTANFRRALNNILPDDIAILEAVDAPDKFSAITNAVRKHYRYTIYTGSVRPVLHIKHCWHYHADLDIDAMNAAAEHIVGKNDFKSFSSSGDHRKNHVRTVFRCEVTEDGDWVYIDVEGDGFVYNMVRIIAGTLVEVGRGRWQADRVKDIVAACDRTKAGPLAPGSGLCLMRIDFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN5</accession>
    <name>A0A1U9NQN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIII-type proteinase</fullName>
            <ecNumber evidence="3">3.4.21.96</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prtP</name>
        <name evidence="3" type="ORF">STSP2_03449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.96" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70243">
        <property type="protein sequence ID" value="AQT70243"/>
        <property type="gene ID" value="STSP2_03449"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03449"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364424" evidence="1">
        <location>
            <begin position="30"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="2">
        <location>
            <begin position="86"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="581" mass="63290" checksum="DF22DE5780F154BB" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT2</accession>
    <name>A0A1U9NQT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70094">
        <property type="protein sequence ID" value="AQT70094"/>
        <property type="gene ID" value="STSP2_03296"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03296"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10932" checksum="F6C0CD3391700AF1" modified="2017-06-07" version="1">MKTQEKTPGVLEVIDFCRQHGFEAELVGKWVWVRFDKRPDQATRRALKDIGFRWSKRRGRWAHNCGHPTKSARESDPWQKYHTRIVSRKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX0</accession>
    <name>A0A1U9NQX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69906">
        <property type="protein sequence ID" value="AQT69906"/>
        <property type="gene ID" value="STSP2_03106"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03106"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="21684" checksum="9F97F92A606F8D12" modified="2017-06-07" version="1" precursor="true">MKRLTLILIGLAVLPWGQAAGGVIFEVNPFTDNGAYNDSEQLTLLVDVSEPTAGMVRFEFRNDSTAASSSIAGVYFDDGLAALGAPVIDNGSGVDFWHGASPPQLGGGLAFNTTYSAGPMRRPPHDGVNSGEHVGFNFTTAPWVDFDDIVSAMNDQTLRVGAHVIALPDGSSEWAVNTPDSVPVPEPATIALLVTGGLFVAAGRKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR72</accession>
    <name>A0A1U9NR72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_03521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03521"/>
    <dbReference type="EnsemblBacteria" id="AQT70315">
        <property type="protein sequence ID" value="AQT70315"/>
        <property type="gene ID" value="STSP2_03521"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03521"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7687" checksum="647766B82FB6158A" modified="2017-06-07" version="1">MSNETEKSGVVCLLLLLLVGFLGAHRFYVGKIGTAILFILTGGGLGIWALIDLIMIITGKFTDAQGNPIPLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG35</accession>
    <name>A0A1U9NG35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative proximal rod protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgC</name>
        <name evidence="3" type="ORF">STSP2_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00030"/>
    <dbReference type="EnsemblBacteria" id="AQT66892">
        <property type="protein sequence ID" value="AQT66892"/>
        <property type="gene ID" value="STSP2_00030"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00030"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="2">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14489" checksum="DD10B795AF4D2A96" modified="2017-06-07" version="1">MPVEKMFDSLDIAVSGIKAQDRSIKSIFSNVANSRTVDAGSGKPYRRVEAILKAQADGLSGVEVSEMAEDMSDFTEILAPGHPNADAKGFLSMPNVNLPVEIMNLGLASRAYQANAAVLKRYQDMVNTSLELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGB1</accession>
    <name>A0A1U9NGB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00110"/>
    <dbReference type="EnsemblBacteria" id="AQT66972">
        <property type="protein sequence ID" value="AQT66972"/>
        <property type="gene ID" value="STSP2_00110"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00110"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021342">
        <property type="entry name" value="DUF2959"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043473">
        <property type="entry name" value="S2_sf_CoV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11172">
        <property type="entry name" value="DUF2959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111474">
        <property type="entry name" value="SSF111474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="219" mass="24955" checksum="464BA3D4FD4FC186" modified="2017-06-07" version="1">MRMTLNSLMSILLLAGGVFLSGCENAYYGVMERFNVEKRDILVDRVQAARDSQNEAKDQFRSALSQFEAVVDFEGGELEEMYDGMKQEYDASQDAANKLSSRIDKVEDVAEDLFDEWEAELDDYSSDELRRASARQLRQTRTNYDGLITSMRLAEARMEPVLESFEDQVLFLKHNLNAVAIASLDDELANMRSRVDVLVDDMEEAIQKAEAFIDEMMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE2</accession>
    <name>A0A1U9NGE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67002">
        <property type="protein sequence ID" value="AQT67002"/>
        <property type="gene ID" value="STSP2_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00140"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30251" checksum="3D3D360E00991F1E" modified="2017-06-07" version="1" precursor="true">MARSVRAFTLIELLVVISIMGLILAIMLPALAEVKDKAYQTVCSSNLKQYGIAVNAYAAGNGGELPRPDNWLYSEKAVEEYFALRGSNACRWHDAEIEPDGLLWPYLKAEKVHVCPSFERFAKSEGSGHAGHDASVPIDVRYSYAMNGYLGTRSVWWRNDPTPGSVKDNPTCGVVRLSALKRPGSTILFTEETLEPIDGVSRYGINDNVMLARWYPLGREDYCDAASGYHSMKNGDPATGRANTVFADGSASNLDVSEAFEFAYPFSVTRDMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG5</accession>
    <name>A0A1U9NGG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein YrrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrrB_2</name>
        <name evidence="2" type="ORF">STSP2_00169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67031">
        <property type="protein sequence ID" value="AQT67031"/>
        <property type="gene ID" value="STSP2_00169"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00169"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="485" mass="55189" checksum="A020594C1C88599A" modified="2017-06-07" version="1">MPILIMHTDVCFPVPTGREVPAKTNSARSEMFEYMDSNPWGSAEEMARNAFELYEEGKHALALQQLEQALDINPENASWFFNAGLTLDAMNRFKSAIAAYEQALELNPEDLETLNCLAVDYTRLGQYDLALATFQRIEQIDASFEPCYCNRIITYTEMDQHDLAEQMFYIAQQLDPDCAICFYNIGNSLFSRQEYKKAIWCWEKTAELEPTHPQINYRIAQAYWASSNKHLARVHFLQELRMNPGDVDVILEFGLFLLENGDLDAAKEKFNRILEINPQSARAIFYLGEIASKQEDMTNATRMFRRAMKINPRVPGPRYRLAKIALARGDTDRAANLLLAELDLEIEEPHVLMAMGAMLLQMGRPSDATDCYLKVVDMDDKNGEAFYQLGLALAVKGDHEGSTHFFEYAIKLGNENANLYADAAFCCVKCDQIGRAAQFIHKARELDKDCARIKKLHRAIKCIRTTQNLQKSFSSVLNKFALVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM9</accession>
    <name>A0A1U9NGM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00103"/>
    <dbReference type="EnsemblBacteria" id="AQT66965">
        <property type="protein sequence ID" value="AQT66965"/>
        <property type="gene ID" value="STSP2_00103"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00103"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30868" checksum="BE559FAF6761274D" modified="2017-06-07" version="1">MAGRIDRRMDAKRKTCSVADNLIIQRAGRAEYQRLARFHYRDTSLGPYAAIFAMCDKRAWGMEKGGVVGAIVYSMPVPNLALRNVVTDGRYAGFGDRRLGLAMLNREVRLISRVVIEPRYRGLGLAARLVRETMPKMNVPFVEAQAVMGKVNPFLERAGMSSIRGAVPVRAARLIELLSAAGIEEEEFVDPAAVHAKLGTLEPDLRSIVEYEFRRFLQAYGRRKNMPDGVERTAYIISKLGERPVYYYWFDPGWKRGDKQSRNADLTGGKYGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ6</accession>
    <name>A0A1U9NGQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
            <ecNumber evidence="2">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">axeA1_1</name>
        <name evidence="2" type="ORF">STSP2_00085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66947">
        <property type="protein sequence ID" value="AQT66947"/>
        <property type="gene ID" value="STSP2_00085"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23706" checksum="395F3FED8540BBCC" modified="2017-06-07" version="1">MGDFGTTSDNAQNPLAETIRLACIGDSITFGAGIVEREVNSYPAQLQSMLGENWRVENFGVSGATALSKGDLPYIDQSEYERSLKFEPDAAVIALGTNDTKPWNWQHRADFINDYRKLVNSYRVKNPNIRIWICRPVPAFGDDGDIKGSLVKDYLPGLIKRVSELTSVPVIDLYTPLKDKPQYFPDTVHPNAEGARVIAAQVWSFLVEAPTEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR2</accession>
    <name>A0A1U9NGR2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flgE</name>
        <name evidence="6" type="ORF">STSP2_00062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00062"/>
    <dbReference type="EnsemblBacteria" id="AQT66924">
        <property type="protein sequence ID" value="AQT66924"/>
        <property type="gene ID" value="STSP2_00062"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00062"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="481"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="561" mass="57663" checksum="A2EE0C66E9C5BF95" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV7</accession>
    <name>A0A1U9NGV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66974">
        <property type="protein sequence ID" value="AQT66974"/>
        <property type="gene ID" value="STSP2_00112"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00112"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="44" mass="4938" checksum="E8BCCEE4277F21C7" modified="2017-06-07" version="1">MSPNGLCAMLRLFLWADQVKFFAVSAIFFGKIAIFSTAINDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW0</accession>
    <name>A0A1U9NGW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">apu_4</name>
        <name evidence="4" type="ORF">STSP2_00302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67159">
        <property type="protein sequence ID" value="AQT67159"/>
        <property type="gene ID" value="STSP2_00302"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00302"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866381" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1533" mass="163163" checksum="1DE08177B4BD5EA4" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY8</accession>
    <name>A0A1U9NGY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium, cobalt and zinc/H(+)-K(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">czcD</name>
        <name evidence="7" type="ORF">STSP2_00156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00156"/>
    <dbReference type="EnsemblBacteria" id="AQT67018">
        <property type="protein sequence ID" value="AQT67018"/>
        <property type="gene ID" value="STSP2_00156"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00156"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31863" checksum="DEC3C806D2418550" modified="2017-06-07" version="1">MHSHSHGHGHGHSHAHGSYDIAFAVGIALNVIFIVVEVIFGLLSDSMALLADAGHNFSDVVGLLIAWAASYATRLKPTHRRTYGWRKASILGALTNSVILFTALGAMTLEAVRRLMNPVEVHAHTVITVALIGVVINALTAAMFMKGRKHDLNIRGAFLHMAADAGVSLGVVFAGMLIGYTGLLWIDPAVSLAIVVVILIGTWSLFRASFNLAMDAVPEHVDVHEVRNYLESLPGVEEVHDLHIWAMSTTETALTAHLLKPSHENDDKLLTDASEALHHRFHIGHVTLQYERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH08</accession>
    <name>A0A1U9NH08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67085">
        <property type="protein sequence ID" value="AQT67085"/>
        <property type="gene ID" value="STSP2_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00225"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26981" checksum="F4D7236DD9F5DF6B" modified="2017-06-07" version="1">MAQTDAIRELAHQAVAVPTLSGKHDTWLWDRTQRLVRNVEHIARLPEITNSGLSVDRFCLTAAAYFCDAGFARYADPEDPANRVSLADVSTSDLHDFSTQIATEKLTNIIPGPKIDKINKIIYESSNRLTKTTEALILADARSLDDMGAVGIFNEFRRYAIHGKSATDALQSWKRKIDYHYWQTRLDESFNFDTVRELAARRFSVAEKFMTQLQLENSARDLEEMILESLDPLNEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH27</accession>
    <name>A0A1U9NH27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67058">
        <property type="protein sequence ID" value="AQT67058"/>
        <property type="gene ID" value="STSP2_00198"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00198"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15850" checksum="6D76B08870B89DA8" modified="2017-06-07" version="1">MQMILREIFKIYPFVLPGLLVYIIFFWSSKEPPSKLKFVGQMEFAIGFVVYLAVGVIPVALEIRLSPSFTLVGFLYGVASMIIGIGLMSGNPIARKSCIAISIIRLFTIIGTIPSIVSLRALCTDNSVRNFFRLDKKQIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH61</accession>
    <name>A0A1U9NH61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp_1</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">STSP2_00415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00415"/>
    <dbReference type="EnsemblBacteria" id="AQT67272">
        <property type="protein sequence ID" value="AQT67272"/>
        <property type="gene ID" value="STSP2_00415"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00415"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="398" mass="43211" checksum="D2EB37B844ED5761" modified="2017-06-07" version="1">MANAVVSQSGGPTGVINASLVGVIEEARNHPDIDTLYGAVHAVAGIVKDEFIDLTDVSDETLEILAASPSSGLGSSRDKPDKAYVEKMINVFKKRNIEYFFYIGGNDSANTCYIVNQVADEMGLDLKAFHIPKTIDNDLRVTDHCPGYGTAAKFVACALMGDDLDNRALPGVKIDVIMGREAGWLTAATALGKQRDDDGPHLQYFPEKPVSMEKMAADIKAVYDKLGRCVVAVSEGIRAEDGNLWGKKLQENAEVDAHGNVQLSGSGALADFLATEIKSRLGIARVRADTFGYLQRSFAGLQSKTDAEEARRCGRQAVIYSKDNDNGSVAMKRVGTGKDYKIELFMTELKNVAEHTKDLDEKYINSEGNGITEAFVDYAMPLVGDLPRTEYLGNRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD0</accession>
    <name>A0A1U9NHD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67177">
        <property type="protein sequence ID" value="AQT67177"/>
        <property type="gene ID" value="STSP2_00320"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00320"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17842" checksum="7EC5679A23FA15A2" modified="2017-06-07" version="1">MARPNGLAFLIPIPPRPYRHQTHIIQVSHCDQRSDPTTSTRRLSSAEGEPRVHHAHACTPKTHPSTTNTQSRHTSYRTHKQNIVTARSKATWQSQPHKKPGLPLTSTMPTPKPYRHPHPQSIIMARSKNACSKNVSGAQDCHPPLADPEKTTGTQARPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE2</accession>
    <name>A0A1U9NHE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atsA_5</name>
        <name evidence="4" type="ORF">STSP2_00487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00487"/>
    <dbReference type="EnsemblBacteria" id="AQT67343">
        <property type="protein sequence ID" value="AQT67343"/>
        <property type="gene ID" value="STSP2_00487"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00487"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="492" mass="54396" checksum="4556157F63EC8FA9" modified="2017-06-07" version="1" precursor="true">MLNRRSFLKKAGFAAVLASSGVRSQVLGADEKSKNRKPNVVFILIDDMGWRDVGFMGSKYYETPNIDRLASEGMVFTDAYANAPNCAPSRACLMSGQYSPRHGVYTVAPSARGKSIYRKIVPTPTKRVLDPAIPTLAEALKPAGYVSASMGKWHLGNDPQAGPVAQGFDLNVGGFQAGHPKSYFSPYRNPELEDGPRGEYLTDRLTDEALKFIETNKDRPFFLYLPHYAVHTPLQAKKQMIEKYKNKEPDGGQNNSTYAAMVESTDKGVGRIMDKLAELGIEDETIVVFFSDNGGHGGVTDNSPLRGSKGMLYEGGIREPLIVKWPGKVKAGSNCDVPVIGTDFYPTLLEACGAKKPAGHVLDGESIVKLLEGGKMLERKAVFWHFPAYLGGYKPSQGVWRTVPGGAVRVGDWKLIEFFDDGHVELYNLKEDIGETNDLARKMPEKAKELHGILKKWQAEVDAPIPTEKNPRFDKEKFDHKDNQLKARAKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF5</accession>
    <name>A0A1U9NHF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ORF">STSP2_00495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00495"/>
    <dbReference type="EnsemblBacteria" id="AQT67351">
        <property type="protein sequence ID" value="AQT67351"/>
        <property type="gene ID" value="STSP2_00495"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00495"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="207"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="576" mass="62721" checksum="05D751288854459D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG0</accession>
    <name>A0A1U9NHG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fkpB</name>
        <name evidence="6" type="ORF">STSP2_00084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00084"/>
    <dbReference type="EnsemblBacteria" id="AQT66946">
        <property type="protein sequence ID" value="AQT66946"/>
        <property type="gene ID" value="STSP2_00084"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00084"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15625" checksum="45C3FE9381CCC7AC" modified="2017-06-07" version="1">MSQAKKGDQVKVHYTGKLDDGTVFDSSEGRDPLDFELGAGQVIPGFEQGTEGMEPGESKTIKIECKDAYGERREEMVQKVSKQELPDDVDPQIGQQYRVPLQNGGSVVVTVSEVTDEDVTLDANHPLAGKNLTFDIELVEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS4</accession>
    <name>A0A1U9NHS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67473">
        <property type="protein sequence ID" value="AQT67473"/>
        <property type="gene ID" value="STSP2_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00620"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="21278" checksum="0F86CF5AE4BC61B2" modified="2017-06-07" version="1">MNQPASNGPTISFDEFGPLEVRPQPGQNYCHTDHPKRLPATYTRKHGVQHWLAFYDVHQKKLWGYVRPRKRHQEFLEVLKLTRKKYPANQRIHLILDNFSPHRKEKVLRYCRENNIHLIWTPTNASWLNPIECQFTHVKEFVIRGTNYQNHNELKIALNRYVAYRNKKNQQKLNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS5</accession>
    <name>A0A1U9NHS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative metal-dependent RNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00640"/>
    <dbReference type="EnsemblBacteria" id="AQT67492">
        <property type="protein sequence ID" value="AQT67492"/>
        <property type="gene ID" value="STSP2_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00640"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001018">
        <property type="entry name" value="Beta-lactamase_class-B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00743">
        <property type="entry name" value="BETA_LACTAMASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143318" evidence="4">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21670" checksum="8E4F53C08903C532" modified="2017-06-07" version="1" precursor="true">MKTASRTITFAVALLTVFISNASAIDSEATKLLKKRNSEFKQEVIKVNEDVYTAVGYSVSTVSMIIGKSGLIIVDTGLDTISAEKVLADFRKISDKPVKAIILTHSHGDHTGGVRVFAGGGKPQIWTRSNFGSEAHPLEQAGLTIQKVRGARQGGFMLPPEKRINNGVAKAYWPKRGGAVFASEKSWKPTHYLSEGPKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW6</accession>
    <name>A0A1U9NHW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.312</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ligC_1</name>
        <name evidence="2" type="ORF">STSP2_00482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.312" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67338">
        <property type="protein sequence ID" value="AQT67338"/>
        <property type="gene ID" value="STSP2_00482"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00482"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050606">
        <property type="term" value="F:4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36767" checksum="2A1B62C99911EC48" modified="2017-06-07" version="1">MTKLRTAVVGAGKMGGIHAKVYDNLDNAELVAVVDTDKERADKLAAQYGCPAFTDPAAIIGKVDAVTISAPTIYHRDLAKLYLENKIPVLIEKPLAASVEEGREIVELAKQNNVIVAVGHSERCNPVAQAMKRLDIDAKFIEANRISPYPFRSTDIGVVLDVMIHDIDIILSLANSKLKSVQAVGVNVIADHEDICNARLLFENGCVANITASRLALKTERKVRVFSRQAYLSLDYFKKEGIVIQTDPNVDVVEWIKKNQADDFDFSDVNWPDLLHIEQLEIDSREPLRVEQESFLKAIADDSASPEVSGEEGLAAIECAHSILDAIKQHKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW7</accession>
    <name>A0A1U9NHW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR repeat-containing protein YfgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yfgC_1</name>
        <name evidence="9" type="ORF">STSP2_00501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00501"/>
    <dbReference type="EnsemblBacteria" id="AQT67357">
        <property type="protein sequence ID" value="AQT67357"/>
        <property type="gene ID" value="STSP2_00501"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00501"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012075418" evidence="7">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="63"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28881" checksum="A6855100612CA775" modified="2017-06-07" version="1" precursor="true">MRKMLFSMLMVAFSGIITGCSTNPVTGERELMFVSSEEEKRIGEEYAPEVEKQLGGAIQNTQLQNYIDSVGSSIVRQTHLAGEDFEFTAVRDKSVNASALPGGHIFITEGMLRNIDDEAQLAGILAHEVAHVTIRHSSQAISRQIGFDLLLQGIGSATDAPAGALTAADLGGQLLQLRYSREDEIEADTYGMDYMLRAGYDPQGLLETMIMLEQLGGGGFEFLSTHPAPANRQAILEDRIRGMRYSDVKRGEADYQRYVLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI06</accession>
    <name>A0A1U9NI06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ald</name>
        <name evidence="11" type="ORF">STSP2_00287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00287"/>
    <dbReference type="EnsemblBacteria" id="AQT67146">
        <property type="protein sequence ID" value="AQT67146"/>
        <property type="gene ID" value="STSP2_00287"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00287"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39759" checksum="AD265A9167742B9E" modified="2017-06-07" version="1">MKIGTVKEIKTRECRVGLTPQCVKAYTTRGHQLFVQTGSGLGTGFTDEQYTAAGATILPTAKEVFDACDMIVKVKEPLPEEYDLFHPGQILYTYLHLAASKELTDALLERKIKAVAYETIETADGSLPCLKPMSEIAGRLSIQEGAKYLEKTYGGRGILLGGVPGVARGKVAILGGGIAGTNACKMAVGLGADVTVLDINPDRMVYLDDIFSTHITTLYSNDHNIEHVLKESDLVIGAVLIPGAKAPKLIKKQHLKMMKPGSVFVDIAVDQGGSAETTRPTTHDEPIYVIDDVVHYCVANMPGAVALSSTIALTSVTLPYGLKIAEQGLESACRQSQPLAKGVNVYLGKCVYEPVAQDHGLKYTPLGEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID9</accession>
    <name>A0A1U9NID9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67276">
        <property type="protein sequence ID" value="AQT67276"/>
        <property type="gene ID" value="STSP2_00419"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00419"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165666" evidence="1">
        <location>
            <begin position="31"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30883" checksum="5F34352D4196E076" modified="2017-06-07" version="1" precursor="true">MIREKSGNKFNSVFLSLLVGLACLGPNIMADDVQGDLELAGGGEYDLDYSVMGNVYVGNIEDSADTTVNMLPGGYVRDALVVSDTGILNVFGGTCDWLVSIASDAVINVYGTNYQVDGEPVGEGVTEVYMPLNELAWVDGDGNDYSLFICSDVMVQLPGLVSDGMNQEPEVINVEVDIKPDSSDNAVNLRSKGVVPVAFVSNETFDATRIDFETVTVNGNVGLIKCRGKKQRPMVSETDVNGDGLVDLLVKLDTQMLADAGVESVCEFTATTYDGMAVRGSDSITVVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ5</accession>
    <name>A0A1U9NIJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sumT</name>
        <name evidence="8" type="ORF">STSP2_00890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00890"/>
    <dbReference type="EnsemblBacteria" id="AQT67741">
        <property type="protein sequence ID" value="AQT67741"/>
        <property type="gene ID" value="STSP2_00890"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00890"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="7">
        <location>
            <begin position="303"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="500" mass="54878" checksum="89A67790BB065706" modified="2017-06-07" version="1">MQGFNKRFVIDHAGGVPYKCSLENLSFKVISRVIMKRNKVYLIGTGPGDPELLTIKAQRLIGRADVILYDHLIPLEVLDHAKADAELICVGKFAGEHTLPQDKINDLMVERANAGYAVVRLKGGDPYLFGRGGEEAAQCKDDGVDFEVVPGITSPLGSACYAGIPLTHRDFSSSVAFITGHRKKGDDRPIEIPKADTLVLMMSVRNIAGLIPSIIDAGYDENTPIAAVEHGTCYDQRVVKGTLSDFAEVIEKTPLRMPAIFIVGGVGQLSGKLGWFAREPKILMLGTHPEKYQHLGVIIHKQIIDIEPLDDYSSAEKMIEGVERYEWIVFTSTNGVRHFFKLADEKGLDARSFANVKFAVIGRTTAETLAEFGISADIVPDLQASQGLLEGFAKLDMAGKKVLLPQAEVSSAELPDGLEEMGAKVDKVAMYRTVEIDPGEVDFDYIDKVLFTSGSTVRAFVNKFGELPENVRGICLGRPTQQVAEQFGMDIEIIPERQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS2</accession>
    <name>A0A1U9NIS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67829">
        <property type="protein sequence ID" value="AQT67829"/>
        <property type="gene ID" value="STSP2_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00980"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012075415" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15082" checksum="F16E99179A5AB1C6" modified="2017-06-07" version="1" precursor="true">MKHKLTLAASLMLLLAILGCPKEDSPSTYPPTSGNFVKNIDGRGIAKVWGIDFEVAETVGGGAASKFEGQLHSDPDQTDAQVEVTIGDDVNIRLEKFPGSPVTLQFNNNNYGTVEVGDKVVIDAQRNVMVNGNLRKPEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT3</accession>
    <name>A0A1U9NIT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group II intron-encoded protein LtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ltrA_1</name>
        <name evidence="3" type="ORF">STSP2_00994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00994"/>
    <dbReference type="EnsemblBacteria" id="AQT67842">
        <property type="protein sequence ID" value="AQT67842"/>
        <property type="gene ID" value="STSP2_00994"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00994"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="524" mass="61438" checksum="C791CCB1D3462223" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV2</accession>
    <name>A0A1U9NIV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-CoA thioester hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00865"/>
    <dbReference type="EnsemblBacteria" id="AQT67717">
        <property type="protein sequence ID" value="AQT67717"/>
        <property type="gene ID" value="STSP2_00865"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00865"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17872" checksum="E464EEA29C5F41CE" modified="2017-06-07" version="1">MADQKPKKPCQSAVTTRYLLMPHHANPHGTAFGGTIMSWIDTVASMAAQRHARTEVVTASIDQIQFRQPINIGDHVLLKASVNYVGRTSMEVGVKVTKENPYTGNSTVATTAHLTFVALDEKHRPTVIPPLEPATDDEKRRFANAQKRLEQRKTEITKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ21</accession>
    <name>A0A1U9NJ21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
            <ecNumber evidence="6">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lacZ_1</name>
        <name evidence="6" type="ORF">STSP2_00738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67590">
        <property type="protein sequence ID" value="AQT67590"/>
        <property type="gene ID" value="STSP2_00738"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00738"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013228219" evidence="4">
        <location>
            <begin position="20"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="48"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="978" mass="108695" checksum="DEE237730FE4A5D6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB6</accession>
    <name>A0A1U9NJB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigW_1</name>
        <name evidence="5" type="ORF">STSP2_01049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67897">
        <property type="protein sequence ID" value="AQT67897"/>
        <property type="gene ID" value="STSP2_01049"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01049"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="22177" checksum="6A7B0C7FCB2D2064" modified="2017-06-07" version="1">MKNRDSFQKTALIHLTQVYRAAFALSGSHDLAEDLTQTTFAKAYQRYRTFKKGSNCKAWLMTILRNTWIDELRRKKLETCSLDAGEYELPHPVEKEETSWTDSDDLLENFGDEQIISALGQLPDDQRLTIYLTDVEEMSHEEVAQILDVAVGTVKSRTSRARSALRNLLQDYSRTEKSNFAEAENEPPEQRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB9</accession>
    <name>A0A1U9NJB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EcoKI restriction-modification system protein HsdS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01067"/>
    <dbReference type="REBASE" id="191334">
        <property type="entry name" value="S.PbaBD1I"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67915">
        <property type="protein sequence ID" value="AQT67915"/>
        <property type="gene ID" value="STSP2_01067"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01067"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="238"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="409" mass="45908" checksum="B8F4EE2A758D30D4" modified="2017-06-07" version="1">MNSSKPKQSLKEGIVIIKGKPPLQQPYYGAGAERYLTPEYLRGNDDAEFVKPCLNAVHVKDDETIVLWDGSNAGEIFRAKNGILASTMAVVRHNDEFDSGYFNYSLKNWENFLKAQTSGSGIPHVDKEIFANLSLISFSRPEQAKIAEVLSTVDQAIEDTEALIAKQQRIKTGLMQDLLTRGIDENGDLRSEKTHKFKESAIGRIPIEWEATPIGESISFIIDYRGKTPPHSNDGVAVISAESIGEDRVRQITKYVTKDVYEKWTTRGLPEPGDVIFTTEAPVGEVACLPGDQTYLLTRRVIALRPQTDILRKQYLFYSLKSAKQRGVWEMFTAGTTAPRIKRPDVTNLRIPLPSAAEQDRILLILAEQWQYVEDTVQAKKKLKALKTGLMQDLLKGKVRVTELLENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE6</accession>
    <name>A0A1U9NJE6_9BACT</name>
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        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68041">
        <property type="protein sequence ID" value="AQT68041"/>
        <property type="gene ID" value="STSP2_01195"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01195"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188763" evidence="1">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20050" checksum="D9FC049408CB0771" modified="2017-06-07" version="1" precursor="true">MKRFGFALISLLCIVAVSPAGLVSLSGVDLLTDYDAGTGVLAINDTAAVTIEESTSIQTTVTGADIQLSTTLSADNSVGGMASGLFTGGSLSFVDSSGSTLLEGTINQIAIGEVFDGMGLLAGTGDFQVTGGSLASEFPDALGEIVQLSFNVSPTTISDYTTDFSARTNLSLMPVPEPATIAMLGLGGLALLRRKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP4</accession>
    <name>A0A1U9NJP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67726">
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        <property type="gene ID" value="STSP2_00875"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00875"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22745" checksum="43E46482103D82B2" modified="2017-06-07" version="1">MKERILAFLSATPFIATFGSVIFFVEKHRAAMLEKGQATVVDGGVMFTGPDQFWLFTPTGFCFVLAILFVLIGVCVVLSKLIAEFSLKLWLPIICIGWVTTVASTFALFHIHRDDYVLLNDKAISQKFGSRNWSAQWDDIRKIQDKGRAFIIYLEDGKTFRISDAQIARLYDSGKLTSHLTKISEITSHIGSEKKFKLIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ8</accession>
    <name>A0A1U9NJQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_1</name>
        <name evidence="9" type="ORF">STSP2_01328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01328"/>
    <dbReference type="EnsemblBacteria" id="AQT68173">
        <property type="protein sequence ID" value="AQT68173"/>
        <property type="gene ID" value="STSP2_01328"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01328"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="283"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="416" mass="44064" checksum="F39964A52BEDFF07" modified="2017-06-07" version="1">MASFTYKGVDRAGNSVSGTVEAADRSLAISVLTAEGTYPTELMEGAVKVSAPKAEKASASKNRKAPVLGSGRVKSKDILAVTEQLSTALSAGLPLLDALDIIRSQQVKPAMRELLGDLEKAVSSGNSLSGAMAEHSEHFSKLYVSMVRVGETGGILDETISQLATILEREEKIKTSMTNALVYPAIVLTLGIGSVIIMLTAILPKIINALGEEVLLPLPTRMLLWLSDFLIVYGWAVGLAVAGAAWFFYSWKNTEQGKHKWDAFKLRVPVLGSVLTKIAVGRFARTLGSLTGCGITILNALSVVRDIMGNEQLGGEIDEVASKVSMGESLGEPLAASGHFPPLLVQLVSLGEQTGKLDEVLLNAARTFDSEADAAITRFMAVFPALIILLLALIIFFIIAGTLLPIVTIDFGGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR2</accession>
    <name>A0A1U9NJR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67978">
        <property type="protein sequence ID" value="AQT67978"/>
        <property type="gene ID" value="STSP2_01132"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01132"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030181" evidence="2">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="27183" checksum="9D4807B1BF3E4849" modified="2017-06-07" version="1" precursor="true">MKLLKIYLMAAMCIAVGLAVQGCQGEEPEEAGAETYQQEEQMQQEEQQQQQREQEQMEREGMPGGMGEEQTQITRSDLANAIESYVREQSQDQDGYMMVTDEVTGEQLKLKLDSVHRDRIAQLNENTYFTCADFETPDGKMYDLDIFMTGQSPDDLEFATVTIHKEAGQERYTWEEEQGMWQMAPVGDTPVPQEAQQKIQQLQEQQQEQQMLQQKEGQSEKHEHPGSGDSGASHEHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR3</accession>
    <name>A0A1U9NJR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl tripeptidyl peptidase</fullName>
            <ecNumber evidence="5">3.4.14.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptpA_2</name>
        <name evidence="5" type="ORF">STSP2_01317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.12" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01317"/>
    <dbReference type="EnsemblBacteria" id="AQT68162">
        <property type="protein sequence ID" value="AQT68162"/>
        <property type="gene ID" value="STSP2_01317"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01317"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012662673" evidence="3">
        <location>
            <begin position="25"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="654"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="877" mass="97837" checksum="424EE6C29C841846" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT3</accession>
    <name>A0A1U9NJT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68075">
        <property type="protein sequence ID" value="AQT68075"/>
        <property type="gene ID" value="STSP2_01230"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01230"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="444"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="552" mass="60160" checksum="360C7B87CC437E1D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV0</accession>
    <name>A0A1U9NJV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68202">
        <property type="protein sequence ID" value="AQT68202"/>
        <property type="gene ID" value="STSP2_01357"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01357"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012279005" evidence="1">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="43033" checksum="840C3FDEC51D0221" modified="2017-06-07" version="1" precursor="true">MKKLLILMTALTLTALVPAAEQGGTGERFWLNYVKSRAAQRLPGVPGVYSSTNKDKPEDVKLPQLENVDWSFRTWKPDLVDTEVLVAVAGTGSGFTLYVDSDQDRDLTDEVAHESWLNEYSSWYFGPAQVILETANGPVTYHLNMRLSAGNRSRPYLSLVTGCWYEGTVVVNGKEKNCMIVDVDSNGVFNDLNPGGRSDRIAIFEDGTGSPIPLTKYVQVDGELYTPTVARDGSYIEIAPAQNVPYGYLEVSDNLSEIIISGTNGYFQPDLGKERKLKIPAGDYIVSRWYISDKDKTGREWRLGRYSSQKSVTVAEDETSELNISSDIYAFLEVSRKGNGYTFNRSMIGADGKSVDLRMGTGGYPPTPKLRFRDASGNYDKTFSLEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK10</accession>
    <name>A0A1U9NK10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wapA_9</name>
        <name evidence="2" type="ORF">STSP2_01418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68262">
        <property type="protein sequence ID" value="AQT68262"/>
        <property type="gene ID" value="STSP2_01418"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01418"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="DUF2235"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="DUF2235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2235" evidence="1">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="449" mass="51294" checksum="DBE6DC9BCEECBE07" modified="2017-06-07" version="1">MGRVLAQYTDIVGTSDYELDRTFVYGNGINDVLVMFLPEDELDENANDDFLSFVDAWLADPNSADWNASWDSNADSIIDFADFCYYASDFDTPDIVETDYYYLKDALGSVVGLIGGKFGRTEEREFYNYDIYGQPSETSTAGNPYMFAGMRYDAELGTYHTLHRTYSPQQGRWFQHDPIGYADSMNLYEYVASNPMTYIDPKGLNLYAIGGTAESHADGYNTERVYRYYEGDGGPRVGKGRYFYDGVGTKKYKPHWFKPIDIFRKLRTWDENLSNMATGKEATEITNRVKKRICKDYCRDKNMQINIVGWSRGAASALEVADQLNEDGCCCDGTTVKPEVNWLGLFDAVEMTTNSMMAEDIASNVKRADHARRTQKVGAWAKQLIFPRVSGETNSSDTVLTTKDFYWKDGRKTSHNDIGTKRPFLRWMMQRGEKAGLTFDWKHYARDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK16</accession>
    <name>A0A1U9NK16_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01441"/>
    <dbReference type="EnsemblBacteria" id="AQT68283">
        <property type="protein sequence ID" value="AQT68283"/>
        <property type="gene ID" value="STSP2_01441"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01441"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="337"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="438" mass="49264" checksum="5C0B98787FC8DC92" modified="2017-06-07" version="1">MQVPFWDERIETASRGDLEALQLERLKKVVDSAFKTPFYKKRLAKAGMSSSDDIKSLEDLKKIPFTTKDDLRKSFPKGLLACDMDEVNRIHSSSGTTGIPTVIYFSGEDVDTWTDLVARCVVCTGASKKDVFQNMMTYGLFTGGLGLHYGAEKAGMTVIPVSSGNTLRQVQIMQDFQTSVVHATPSYMLHIRTVLDENDISLKQLNLQKAFIGAEPHSENVRKKIEELYNIDAYNSYGLSEMNGPGLAFECVHKAGMHFWEDGYIVEIVDPETDENLEDGEPGEVIVTNLIRHATPLMRYRTRDLASILPGQCECGRTHRRLSRIKGRTDDMLIINGVNVFPSQIEEVIMKIPEVGTNYQICLDKQGALDRLTVQVEIYSKMFTGSAGELENLRHRIVEKLKGTITIKPLVKLHEPGFLPVYEGKAKRVIDERPKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK55</accession>
    <name>A0A1U9NK55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="1">IOR</shortName>
            <ecNumber evidence="1">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01447"/>
    <dbReference type="EnsemblBacteria" id="AQT68289">
        <property type="protein sequence ID" value="AQT68289"/>
        <property type="gene ID" value="STSP2_01447"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01447"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="358"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="55733" checksum="21BFCFBAC70015D1" modified="2017-06-07" version="1">MEKAFLSGNEAVAFGAYEAGMQVACAYPGTPSTEILEAIAEFPEIDAQWSVNEKVAYEVALGAAVGGVRSLYACKHVGLNVAMDPLMTSSYTGINAGFVIVVCDDPGMHSSQNEQDTRWVSLYSKMPMLEPSSPSEAKEHVARAFDISEEFDTPVIVRMTTRISHTKEDMVLGKRVEKETAPLSYDEKKYVMIPAFARKRHVVVEERLGKLKDFAETTDLNEITINDKSVGFLTSSIPYHYLKEEYPDASYLKLGFSYPFCDDKIREFADSVDKLVVVEELDPFFETHLAAMGLEFETKDATFQTGELTPDVMKDVVEGKKRPAPAAVAKRPPRLCPGCPHWFSFATLKKHNIYVAGDIGCYTLASLPPTSAMHTCVCMGAGVTFNEGLRKAHPNEKILGVVGDSTFVHSGVTGLINAAYNGSKGVIMIVDNSITAMTGGQQNPATGLTIRNERTKLLDLEALCKSCGADNVDVIDPTNRKEFDALVEKRVTEDALSVIIAKHPCKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB0</accession>
    <name>A0A1U9NKB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68247">
        <property type="protein sequence ID" value="AQT68247"/>
        <property type="gene ID" value="STSP2_01403"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01403"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012391813" evidence="2">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="13431" checksum="85868408F477923F" modified="2017-06-07" version="1" precursor="true">MVETLSRLLAILLVAVAMFSSISMASEDITASDSEITSEDFRAFQTIVLVYLTYHFFFTCEWRFLWKLWKYAFYVSLLSSLFRFSWLINVRDLYDAIVFILILPIILVFGWDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG6</accession>
    <name>A0A1U9NKG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68224">
        <property type="protein sequence ID" value="AQT68224"/>
        <property type="gene ID" value="STSP2_01380"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01380"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="465" mass="52916" checksum="F17BF25B92C59249" modified="2017-06-07" version="1">MVKKVVLNVIVYLAFQPFGGFARGEYLTDYVSIFNQQAKPSNYDKGDNAASDYDKAIELFHEAGISIEKEDIRCWPNELKEQKQKEIEKWLQQNDSAIEHVLAGTQKPYYWKKMKSSNDSITGISTSNLGTKEDLMRLLCYRAKLKAVHGDIAGAVEDLAVVCKFGKHMTGPKTVVEQIVGVSFQRQAVETALMVLDRAEVKGEELEVFDSLLQICKADTNLDFMPLRLIAEESLQWAYISDGKSMAFSEKGFHNRRSRLNLHFHNLFYRNGIFLGGFRKGHEADMSYAIAEKSIMQGMDELEHICRLEAWQLHQLMNDDLNVLAITQRSHPFLNTIALVALNHEICAFERFKAYVEGLEATLGVLRFADEEGRLPEGLDELQHAGIMALLPMDPFSGDEIKYKKVGDSFTIYSYGLDFDDDAGKRWVANYLRPSDDGDLVMFPSPRKKPKVMNPLFDVRWPKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH3</accession>
    <name>A0A1U9NKH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_Apea domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68234">
        <property type="protein sequence ID" value="AQT68234"/>
        <property type="gene ID" value="STSP2_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01390"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041229">
        <property type="entry name" value="HEPN_Apea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18739">
        <property type="entry name" value="HEPN_Apea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Apea" evidence="1">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="441" mass="50259" checksum="F5AC212489376370" modified="2017-06-07" version="1">MCDVVALLKNQKLKKQVVATMQSVYSYAGTIHDNYDKDWWEAWQDAEIYGEADKIDHAFEKYVFSKMRSPYNISPREIRDVFEELWMGSPDLETIDFETMYEIFVSRIGHGELSWRRSDPFMIYSFEADDKDEFIDGFLYGSLYARVKKGEDVKLDLNALRNSKEVLWSKNWMQITLEGVNYVPDERKTYGHLLAVLEGTMSALTCQQLKQDLSPVLQSIAKSAALVMPDSNSVPQESDSQSNSSDLEAFLRELISPSSTFPQLKINLKLIVSEAMEAYFAPKPKKDSFEKRLFNAISLLSQADFQQNPAVGLALAITSIEALLGENTGELSEKLSLDVAALLEPSVEKRNAAAKFVKRLYNSRSRVLHGEDSVGQKHLYEEARLLSSSILLSIISRQSFLRRMGIPTKKPKEFLSELRENRFESNLPMGVPELNVRSLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI4</accession>
    <name>A0A1U9NKI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68248">
        <property type="protein sequence ID" value="AQT68248"/>
        <property type="gene ID" value="STSP2_01404"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01404"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="28112" checksum="4F406AD5A5581511" modified="2017-06-07" version="1">MKNTRQQKILKPLDDFDEAVSLWNIMPSGSGKAVQLLRKIVDQVHEDRFSNGSVRYPSLLIHGHEGKRTLARAFVNSLGFDEADEIYGRFMDADHRAKAFFGKQGEVSHVILDAEKIRPVTLSIIWEMIEKGEHDFTNILGQKENIFISGPLILTTSDIGRVHKSIRDAAGFTVEVEPFSEEQMKLIIHQRLVFCGIKYEGEDVLEAVVNAGGGSVSDSIKLLRMAYVMMRADGRGKLSGNDIERTLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL4</accession>
    <name>A0A1U9NKL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68056">
        <property type="protein sequence ID" value="AQT68056"/>
        <property type="gene ID" value="STSP2_01211"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01211"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18634" checksum="9DD4F381CA5B5482" modified="2017-06-07" version="1">MNSALKKHGQRLVENLSRTLETKVWMQQLLIFLMAGILGWIAGTVLAEIFIKTDRTSQQEQLSSGSSTISTLRMSDQKTHPAAERGTSFSGCGLIPSFSRSSIEVSHNGPKQIFWTAPLTILLVKMPKPSNRFDWRCRIVLQRNLMARYLYMQNLADFLIFRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT1</accession>
    <name>A0A1U9NKT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68552">
        <property type="protein sequence ID" value="AQT68552"/>
        <property type="gene ID" value="STSP2_01719"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01719"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013115390" evidence="2">
        <location>
            <begin position="27"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="779" mass="85652" checksum="A16D45CF7DE80E0C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU5</accession>
    <name>A0A1U9NKU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PEP-CTERM system TPR-repeat lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68344">
        <property type="protein sequence ID" value="AQT68344"/>
        <property type="gene ID" value="STSP2_01503"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01503"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012730664" evidence="1">
        <location>
            <begin position="20"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="933" mass="105434" checksum="55D9E7928137FB92" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV2</accession>
    <name>A0A1U9NKV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase biotin carboxylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01376"/>
    <dbReference type="EnsemblBacteria" id="AQT68220">
        <property type="protein sequence ID" value="AQT68220"/>
        <property type="gene ID" value="STSP2_01376"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01376"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="83"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="438" mass="51150" checksum="AE497AA00851FC59" modified="2017-06-07" version="1">METQKKNIFVLGMDEENAEKLNQVPGSENLIFHQLLSYDYIHDFEHTPMDEIMESARQQLKGFDGSIDGMLWLFDFPGVLMGPILCKEFGIQTAEPLSVFKAENKYLSRVEQQKVIPECTPKFFGFNPGDPESIKKIDLEYPFWIKPAISFSGHLGFEIKSDQDLGHAVDQIQHRKDLFADPYFTLEKQIEMSEDMHHASEKIFVAEQIISGKQCTLEGYIYNGEFDFHGLIDSFRYPNRMSFSRYQYPSKIPQRVQKQMHEKAEKILRRMGYENASFNIEFFWDRKNEELWLLEINTRISQSHCNLFKMVDGVLSHKIPIDLALGRRPELPHRKGEYKLAAKLFLRSFIAGKVTRSPSKEQIREIEKEFDAEITHTVTEGMQLEDLKWQDSYSYVLTILYLGAQSQKELLDKFDIIANKLDIEVEGKKIRSKQGRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV7</accession>
    <name>A0A1U9NKV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">recA</name>
        <name evidence="12" type="ORF">STSP2_01518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01518"/>
    <dbReference type="EnsemblBacteria" id="AQT68358">
        <property type="protein sequence ID" value="AQT68358"/>
        <property type="gene ID" value="STSP2_01518"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01518"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39106" checksum="11074B8B5C4ACFC6" modified="2017-06-07" version="1" precursor="true">MAKAKKTAKKKTTKSKAKASSATKKEAESPSNAALDRAISQIEKQYGSGSIMKMDEANIAQVEGIPTGALSLDLALGGRGIPRGRVCELFGPESSGKTTIALHAIANAQKKGGVAAFIDAEHALDTTWAKKLGVDISSLLVSQPDTGEQALDIAEMLVKSNAVDIIVVDSVAALVPAAEMQGEMGQSHVGLQARLMSQALRKLTGAISKSKTCLIFINQIRMKIGVMFGNPETTPGGNALKFYSSVRMDVRRVSTVKNSAGEAIANRVRTRVVKNKVAAPFKKAEFDLYFDSGISHESDLIDLGVECDVVQKSGAWFNYGDIRLGQGKDNAKNMLLENPDLVEEIEQKIFEAKGLEEQTPKKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW7</accession>
    <name>A0A1U9NKW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfotransferase (ASST)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01528"/>
    <dbReference type="EnsemblBacteria" id="AQT68368">
        <property type="protein sequence ID" value="AQT68368"/>
        <property type="gene ID" value="STSP2_01528"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01528"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="514" mass="57986" checksum="79FB6255CAF8CE82" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ6</accession>
    <name>A0A1U9NKZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68260">
        <property type="protein sequence ID" value="AQT68260"/>
        <property type="gene ID" value="STSP2_01416"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01416"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9825" checksum="EF7D1CA2309D99D5" modified="2017-06-07" version="1">MKKPQAHHDLPQKFKDRFSRLGLDINNPKHMRWVEGGPHGNHQKWSHEFNKQWERFFQNPDVTAKDAVKFMNNLRQNTKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL36</accession>
    <name>A0A1U9NL36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68652">
        <property type="protein sequence ID" value="AQT68652"/>
        <property type="gene ID" value="STSP2_01821"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01821"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9963" checksum="3C7A680E430BE4E4" modified="2017-06-07" version="1">MSTVILYRWSFLWHWNIMQNTANTTAITKPIATSKSVSIFVDPGSINQKALLSTPNFYFVYAETHGRVSKNLTSAPLVNSARPKDTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC8</accession>
    <name>A0A1U9NLC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">dnaG</name>
        <name evidence="16" type="ORF">STSP2_01710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01710"/>
    <dbReference type="EnsemblBacteria" id="AQT68544">
        <property type="protein sequence ID" value="AQT68544"/>
        <property type="gene ID" value="STSP2_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01710"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="600" mass="66509" checksum="22E3BAF012857E47" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL1</accession>
    <name>A0A1U9NLL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01796"/>
    <dbReference type="EnsemblBacteria" id="AQT68628">
        <property type="protein sequence ID" value="AQT68628"/>
        <property type="gene ID" value="STSP2_01796"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01796"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28727" checksum="BC586AECF612A106" modified="2017-06-07" version="1">MFDVKDKAVIVTGGGGVLCGAVAKDLASRGAKVCIVDYHEESAKRKAEEINEAGGQAWGVKGNVLETEAMKAAFDFAVEKMGCVDVLINGAGGNRKEATTSEQMSFFDIPADAIRSVFDLNFLGTVIPSQIIGKYMCENSGGVILNVSSMNAFRPLTKIAAYSAAKAAVSNFTQWLAVHMCQNYSDNIRVNALAPGFFLTEQNRFLLTEEKTGDLTPRGKTIIDHTPMDRFGDAEDLCGTVLWLVSDASKFVTGIVVPVDGGFSAFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL2</accession>
    <name>A0A1U9NLL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bglX_1</name>
        <name evidence="4" type="ORF">STSP2_01792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01792"/>
    <dbReference type="EnsemblBacteria" id="AQT68624">
        <property type="protein sequence ID" value="AQT68624"/>
        <property type="gene ID" value="STSP2_01792"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01792"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012685379" evidence="2">
        <location>
            <begin position="20"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="713"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="940" mass="104969" checksum="99A615283BE61D7C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM1</accession>
    <name>A0A1U9NLM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0251 protein STSP2_01806</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0251 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68638">
        <property type="protein sequence ID" value="AQT68638"/>
        <property type="gene ID" value="STSP2_01806"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01806"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00674">
        <property type="entry name" value="UPF0251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002852">
        <property type="entry name" value="UPF0251"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37478">
        <property type="entry name" value="PTHR37478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02001">
        <property type="entry name" value="DUF134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13353" checksum="DFA384C123497429" modified="2017-06-07" version="1">MPRPVRCRRVGMTPKCTYFKPQGVRLSALEVVGLTVDELEAVRLADLEGHYQQCAAEKMGVSRQTFGRIIESAHKKIAEALVNGKALSIEGGVVNLPEEARGRGQGRGRRRRGGGPGRGRCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM9</accession>
    <name>A0A1U9NLM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FtsH protease regulator HflK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02028"/>
    <dbReference type="EnsemblBacteria" id="AQT68852">
        <property type="protein sequence ID" value="AQT68852"/>
        <property type="gene ID" value="STSP2_02028"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02028"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="310"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="686" mass="75562" checksum="DE02AE590ED4EF9A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS2</accession>
    <name>A0A1U9NLS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68684">
        <property type="protein sequence ID" value="AQT68684"/>
        <property type="gene ID" value="STSP2_01854"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01854"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11786" checksum="0D89315F34D47E1A" modified="2017-06-07" version="1">MEATVIEQRKDTRSQLAWPISVWLPEASRFFNGSSINISKGGAYLEVPMTTPVRPGHEIELNFPRTAALAKQKGSYARIKTGKVVRVDREKMLEEARIGLAVQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS9</accession>
    <name>A0A1U9NLS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argH1</name>
        <name evidence="5" type="synonym">argH</name>
        <name evidence="8" type="ORF">STSP2_02068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02068"/>
    <dbReference type="EnsemblBacteria" id="AQT68891">
        <property type="protein sequence ID" value="AQT68891"/>
        <property type="gene ID" value="STSP2_02068"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02068"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="367"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51348" checksum="2DC920ADBD793C6B" modified="2017-06-07" version="1">MAKGEKSWEKRLSGEVDQLAVNYVESLSYDRRLYKYDIQGSIAHAQMLCAKGFLTADELDAIKGGLAQIQDEIEAGQFEFNVLQEDIHMAVEAALTEKIGDPGRKLHTGRSRNDQIATDMRLWMREEIDILRSKVRDLQGAFVELASKYTKDMMPAYTHLQRAQPIAIGAYLLSFVEMLERDYQRLGDCRKRVNVSPLGSGAVAGSTIPLDRAMTAELLGFEGVMRNSMDGMSDRDFCAEFTFACSLAAVHLSRFAEDFIIYSSSEFDFVRIDDKYCTSSSMMPQKRNPDMLELMRGKTGNIFGSLSAMLMMLKSQPSTYNRDMQEDKLHIFSAADVLRASLDIATAIVSNTQFKTADIAAGLDKGFLDATCLAEYLVRKGVPFRKAHGIVGGLVAECEKQGLAKLADLPLETFTDACDVIEKDVYDNLGATNVVKQYASAGSAGTKQVEEQVAFWRQEFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV6</accession>
    <name>A0A1U9NLV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tdh</name>
        <name evidence="8" type="ORF">STSP2_02098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02098"/>
    <dbReference type="EnsemblBacteria" id="AQT68921">
        <property type="protein sequence ID" value="AQT68921"/>
        <property type="gene ID" value="STSP2_02098"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02098"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="12"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37481" checksum="9E083F77EE96DCB2" modified="2017-06-07" version="1">MKALVKKYPEPGLWLDDVPEPEIGINDVLIKIEKTAICGTDVHIYNWDEWAQKTIKTPMTVGHEFVGRIVDMGSNVHDLKKGDLVSGEGHIVCGRCRNCLAGRRHLCKDTKGVGVNRTGAYAEYLAIPVTNVWLCDPNIPTDVLSCFDPLGNATHTALEYDLVGEDVLITGAGPIGIMSVAIAKKAGARYVVVTDVNPHRLEMAKAMGADHTVDVRSEKIEDAIKALAMTEGFDVGFEMSGNPTAFNDMIHNMAHGGKIALLGILPETSIDWDAVVFNGLTIKGIYGRRMYETWYKMTTLIQSGLDITPIITHRYHYTEFEKGFEAMKSGKSGKVVLDWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM32</accession>
    <name>A0A1U9NM32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68650">
        <property type="protein sequence ID" value="AQT68650"/>
        <property type="gene ID" value="STSP2_01819"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01819"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14860" checksum="157D6C38CFDCF1C4" modified="2017-06-07" version="1">MAYKGLKNRAIQTIACLLLLAAAVLVSGCNRYWYQSGISFDQAVQDWEDCEAELRKRSTLDNRWSSYPVEFEKACMKQKGYELLREGKLPLTAKRQDPESVDLVNFGVAGELDNGDATLEDSDEPEGDLDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC5</accession>
    <name>A0A1U9NMC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68985">
        <property type="protein sequence ID" value="AQT68985"/>
        <property type="gene ID" value="STSP2_02163"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02163"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13225" checksum="9ECCDD5D80014B5A" modified="2017-06-07" version="1">MLKSALSTMPVSSASRVGDEVVNECDFDVVVQMHMPLLAELVGEFESMCPCRICRDDLMRVAVVSFRNSVEAYEFCTDVDYWEFCKPEVSQCLADAVRYALYVNSCDAEKDCGRVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI0</accession>
    <name>A0A1U9NMI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ORF">STSP2_02121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02121"/>
    <dbReference type="EnsemblBacteria" id="AQT68944">
        <property type="protein sequence ID" value="AQT68944"/>
        <property type="gene ID" value="STSP2_02121"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02121"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="336"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="487" mass="53803" checksum="0663A7B6CAA44E34" modified="2017-06-07" version="1">MSDLEYKVIVGLEIHVQLATRTKMFCSCELGFGQEPNTSVCPVCLGMPGSLPVMNKQAFEYSVMAGLALNCNIPSFTKWDRKSYYYPDLPKNYQISQYDLPMSEHGYIEIPLEDGSTKKIRILRAHLEEDAGKNTHTLGNFTAVDLNRAGTPLLEIVTEPDLSSGAEVKALAVELQRIVRYLGVSEADMQKGHMRFEPNVNLHITRGGQLYKTPISEVKNLNSFRALEGSVTYEAARQLDEFLETGITMESGNKRTYGWDDENNRTVLQREKEEAHDYRYFPDPDLVPVVMTPEWLDDIRSRLCEMPLAMEKRFVTEYGLSEYDAGVITSEKATADLFDNAVKAGADPKRVCNILTQTGAKLAKDKECSVAELGVNSENLTALAKMIDDGDVGASAAAQVFELMVETGDTPGQVAEKHNLIQKSDASEIESLVDAVLADNAQAVEQVQAGGKKSKKARGFIMGQVMQRSKGQANPKVVNQILAKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ0</accession>
    <name>A0A1U9NMQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase 1</fullName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="1" type="ORF">STSP2_02192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02192"/>
    <dbReference type="EnsemblBacteria" id="AQT69014">
        <property type="protein sequence ID" value="AQT69014"/>
        <property type="gene ID" value="STSP2_02192"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02192"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29644" checksum="4D990D9F79846505" modified="2017-06-07" version="1">MKQVKALVLRAAGINCDYESVHALELAGAAADRIHINRVIENTDLLKEYQILLFPGGFSYGDDVAAGKILANQIVHHLSEPLTQFLADGKLMLGICNGFQVLAKTGILPGFADDRAGNKSVTNLTEPAVSVIDNDSGKFEDRWAYLQSESEHCVFIKKGQRIYLPVAHGEGKVVTRDESVLSKLENEDHIAFRYVDADGKVGGFPVNPNGSFNSIAGLTDSTGRVLGLMPHPERFVRRTQHPHWTRLEGDSEADGMIIFNNAVEYVKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX5</accession>
    <name>A0A1U9NMX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69078">
        <property type="protein sequence ID" value="AQT69078"/>
        <property type="gene ID" value="STSP2_02264"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02264"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="1">
        <location>
            <begin position="388"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126051" checksum="69DFFED714E9F412" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN21</accession>
    <name>A0A1U9NN21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02083"/>
    <dbReference type="EnsemblBacteria" id="AQT68906">
        <property type="protein sequence ID" value="AQT68906"/>
        <property type="gene ID" value="STSP2_02083"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02083"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="444" mass="50007" checksum="77706A80536377D2" modified="2017-06-07" version="1">MIGLNGCSVTESFQCSRSVPQIMGWKMCGEKIEKDRSFAFTKESCMPMTQRICLVLCCLGLLTAGLGCATHEEQRQAMHDRWEKTSAKAKIPLGREFLNNGRNKDARKVLQKCLDADSEMPEAHILMGRLEVKEGRIAKAQGHFETALQSDDTSDEAYYWLGVITERQEEYQNAADLYAKAYEIQPDEIKYIRSCAGMYVALGEDDRAMELLTSANSRLASSFELKVVTADLAQRMGDTIRAIDLYREALMIEPRDTDVIAALGYCYIEEKEWQSASQIFEQLLDDSNGASRQAYLNLLAMCSVNSGNYGKAVKYYDELSVERRDDPVVWLKMGQAALGAKAANRAIECADRALRMKPGYAEAYALKGCALYVKKRYEESIRVFKNIRRDKSLGALAWMMTGRCYEKLSIFEKAEKAYDMARELNPDSKLLSSIGDSGDSLPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN43</accession>
    <name>A0A1U9NN43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02444"/>
    <dbReference type="EnsemblBacteria" id="AQT69255">
        <property type="protein sequence ID" value="AQT69255"/>
        <property type="gene ID" value="STSP2_02444"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02444"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="187"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="437"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="550" mass="59768" checksum="C97E4AF33E88C55B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN57</accession>
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        <name evidence="4" type="primary">cph1_7</name>
        <name evidence="4" type="ORF">STSP2_02426</name>
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    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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    </organism>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="STSP2_02426"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02426"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
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    </dbReference>
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        <property type="entry name" value="PAS_4"/>
    </dbReference>
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        <property type="entry name" value="PAS_fold_3"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="474"/>
        </location>
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        <location>
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            <end position="521"/>
        </location>
    </feature>
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            <end position="603"/>
        </location>
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        <location>
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            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="752"/>
            <end position="985"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="985" mass="112587" checksum="5572E6FB8FF26E97" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN80</accession>
    <name>A0A1U9NN80_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69194">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28218" checksum="44D1E29A1E8B1DB5" modified="2017-06-07" version="1">MRVKRAFTLIELLVVISIIALLLAIMMPALGMVKEKAKSVVCKSQLRQMAIALQTYAGENNGKAPDFGASYGADPDGFWFVGLAPYLAGDDPYEEKMEILTCPSTKVSPDNGTYIPGTDKNGWVFQGSVKGSYGINFWVMSGSLRGFSAERRFQNFSSLRGGLPTFADSTWPDGHPDGDDQVPLDVYGGGYGGENINTRFPGSMGYGMGRFCIDRHGMAINVAMTGGSVETVDLEDLWVLKWNQLSKPNYDIVLPTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="773" mass="87534" checksum="A2E6B9EEC67B76C6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB1</accession>
    <name>A0A1U9NNB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor SigX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigX_1</name>
        <name evidence="4" type="ORF">STSP2_02406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02406"/>
    <dbReference type="EnsemblBacteria" id="AQT69218">
        <property type="protein sequence ID" value="AQT69218"/>
        <property type="gene ID" value="STSP2_02406"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02406"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="20202" checksum="D8DACBC3ABDBDF58" modified="2017-06-07" version="1">MAAKEPKSKQFFRLYTAAQSRIYAFLLSLVHNHSDAEDLLQETASILWENFDQFDRTKSFSAWAIGIARNKAFDFLKSKKASRPLFNEQFYRDISRIAEQESESAPERLKALRQCMKKMSPSNQKLINLRFEQGVGVKQISQATGHSADAIYKRISRIYSALENCISRSLVSRGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH5</accession>
    <name>A0A1U9NNH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ORF">STSP2_02536</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02536"/>
    <dbReference type="EnsemblBacteria" id="AQT69347">
        <property type="protein sequence ID" value="AQT69347"/>
        <property type="gene ID" value="STSP2_02536"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02536"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="676"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="934"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="934"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118579" checksum="7B9F25F91FA974BF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN1</accession>
    <name>A0A1U9NNN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02596"/>
    <dbReference type="EnsemblBacteria" id="AQT69407">
        <property type="protein sequence ID" value="AQT69407"/>
        <property type="gene ID" value="STSP2_02596"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02596"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16512" checksum="E4B2EC7A73FD6396" modified="2017-06-07" version="1">MPNNTSEHLKLNELLTSQRLAVLCTQHQGQPYANLVAFSTSEDFKVICFATPRKTRKYDNIKQDGRVSLLVDDRENTAGDFTNAVAATAVGKAIEVEKPRADIFGRYLGKHPELEPFAKSEDSAFFCVNVDSYIFVDNFQHVTEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR9</accession>
    <name>A0A1U9NNR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-0--gamma-glutamyl ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02746"/>
    <dbReference type="EnsemblBacteria" id="AQT69553">
        <property type="protein sequence ID" value="AQT69553"/>
        <property type="gene ID" value="STSP2_02746"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02746"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33959" checksum="690C4417B557E133" modified="2017-06-07" version="1">MRKIEVLGLETIGDIEQGDDLAEIVSDAAEQEVAGLREKDVVVLTSKIVTKACGLVFKMENIEPRPQAVRLAEKIGKDARLIELMWQRGLKIVALIPVDGALKKILQSSGKNDEKVQEVCDREKVICVTKDCKSWRFYTHDGGLDRSNFPPGLIGVLPEDPDAEARKIGERLRDITGKNVAVIIADTEIVPIGTFEAAVGSWGIRPRTKDLGAIDRYGRPKFGGLDLTVHQVSGACGLLFGQSDAWVPAAIMRGVDYEFVEDENVGDTLWLGEMSDAEVTHMFSLIFEKSAAVTGTKAKMALKVLSKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS6</accession>
    <name>A0A1U9NNS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">epsE_3</name>
        <name evidence="4" type="ORF">STSP2_02764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02764"/>
    <dbReference type="EnsemblBacteria" id="AQT69571">
        <property type="protein sequence ID" value="AQT69571"/>
        <property type="gene ID" value="STSP2_02764"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02764"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="620" mass="68436" checksum="BC50AA5E0542CAE0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW2</accession>
    <name>A0A1U9NNW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylene monooxygenase electron transfer component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xylA_2</name>
        <name evidence="7" type="ORF">STSP2_02678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02678"/>
    <dbReference type="EnsemblBacteria" id="AQT69487">
        <property type="protein sequence ID" value="AQT69487"/>
        <property type="gene ID" value="STSP2_02678"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02678"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="40192" checksum="BA2F29180E952B96" modified="2017-06-07" version="1">MMTVVLSVLAVSSIGAGLALLLVISEKTVGNYGECTIDVNGEEEIKVQGGKSLLSVLTDQKLFVPSACGGRGTCGLCKLKVPEGAGHLMPTELPFLEKDEIENDYRLACQVKVRNNLSILVPKELLSVSEFTAKIAEIKDLTHDIKQFRFELVEPDRIDFTPGQYIQLKTPSYKSGIEEVYRAYSISSDPADKNAVETIVRLVPGGICTTWLFEYIGLDDEITMNGPHGEFHLSDTDAPAIFIAGGSGMAPIKCILHHMKNMDIQRPATYFFGANKVKELFLLDEMKQFEQELANFKFVPVVASPEEDEQWDGETGLVTDAVRRNVSNAAECEAYLCGSPGMIDASVKVLGELGMAEDKIFYDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP27</accession>
    <name>A0A1U9NP27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69671">
        <property type="protein sequence ID" value="AQT69671"/>
        <property type="gene ID" value="STSP2_02865"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02865"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234090" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13682" checksum="27E48B6D599059AF" modified="2017-06-07" version="1" precursor="true">MRTTAYLCCCLAFVLSTAASKTVGILNRTTNAPIVTSYQQCCDLGPDTRIWPELRETRKTSTFPIITTDTAILTRRNITENSSAILHISTSDTEILPLDLPQNTSTDTTATTSFSPDFVLDLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP64</accession>
    <name>A0A1U9NP64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxy-S-adenosyl-L-methionine synthase</fullName>
            <shortName evidence="1">Cx-SAM synthase</shortName>
            <ecNumber evidence="1">2.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">cmoA</name>
        <name evidence="4" type="ORF">STSP2_02928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69732">
        <property type="protein sequence ID" value="AQT69732"/>
        <property type="gene ID" value="STSP2_02928"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02928"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01589">
        <property type="entry name" value="Cx_SAM_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005271">
        <property type="entry name" value="CmoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF2">
        <property type="entry name" value="PTHR43861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006325">
        <property type="entry name" value="MeTrfase_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00740">
        <property type="entry name" value="TIGR00740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="65"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1 2">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1 2">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1 2">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006325-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="27659" checksum="04BBC447F470E33B" modified="2017-06-07" version="1">MDHSGDIDNVFAHYQERVSGFVFDDKVASVFDDMIRRSVPGYATVLGMVHVFAEHFAQPNSNCYDLGCSLGGGTIAMLRGIKQSGCKVIAIDNSPAMLARCEQILQNEKSKTDVQLVEADVADMTFENASVVVCNYTLQFLDTTGREELIERIYEGMLPGGVLILSEKIKFENTQEQEFFTDIYHDFKRLQGYSDLEISQKRKALENVLVPDSTETHLQRLKNAGFSRIHQWFQCVNFVSFAAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP74</accession>
    <name>A0A1U9NP74_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ORF">STSP2_02938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02938"/>
    <dbReference type="EnsemblBacteria" id="AQT69742">
        <property type="protein sequence ID" value="AQT69742"/>
        <property type="gene ID" value="STSP2_02938"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02938"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="11149" checksum="179AE45D656EAFA6" modified="2017-06-07" version="1">MAKKGSKNDITKLTFEQSIENLREIVEHIERGEVPLQESIEQYEQGMELIKHCRTILAGAEKKIEKIAAEQQQENEEPAEEEIEEDFDDEDEEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP84</accession>
    <name>A0A1U9NP84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_1</name>
        <name evidence="9" type="ORF">STSP2_02610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02610"/>
    <dbReference type="EnsemblBacteria" id="AQT69420">
        <property type="protein sequence ID" value="AQT69420"/>
        <property type="gene ID" value="STSP2_02610"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02610"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="337"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="47654" checksum="C2745330A2C493E7" modified="2017-06-07" version="1">MIFRFKRTLKLGVKSLWMHRLRSTLTMLGIIFGVSSVVSMLAIGEGASQDAQEKISQLGSRNIIIKTVPPPEDKSSIGQQQTLKEYGLTYDDAERFRGAIPNVRVLVPNRRISDQALYRNSRVSTEVIGTVPWYREILSLSLKYGRFITTTDTHYKQAVCVIDDKVRNELFLFDDPLGQNIKVGGDYYSVVGVVSAQKDIAASELQGGKNNPEKERGANTGKIYIPLTTARTRFGETSIQMGAGGATLERVELQEIIVQSRTIDQVLSTRRSVQSILSRFHKKNDYEIIVPLELMQRAKDVQRIFTIVLGSIAAISLLVGGIGIMNIMMATVSERTREIGIRRALGARQRDIVMQFLSETLILTLCGGILGMAVGSLIPILVTYFGQMRTVITPGSLVLAFGISAAVGLAFGIYPAYRAAHMDPIESLRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP88</accession>
    <name>A0A1U9NP88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02747"/>
    <dbReference type="EnsemblBacteria" id="AQT69554">
        <property type="protein sequence ID" value="AQT69554"/>
        <property type="gene ID" value="STSP2_02747"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02747"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120696" evidence="5">
        <location>
            <begin position="29"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="463"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="591" mass="66645" checksum="9B5DCEC81DCD1EAD" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA4</accession>
    <name>A0A1U9NPA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT_3</name>
        <name evidence="3" type="ORF">STSP2_02525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02525"/>
    <dbReference type="EnsemblBacteria" id="AQT69336">
        <property type="protein sequence ID" value="AQT69336"/>
        <property type="gene ID" value="STSP2_02525"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02525"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="378" mass="42139" checksum="C6352739D955AFA8" modified="2017-06-07" version="1">MAKGQPIEHKEFTDKKPDIDRLFNYMIKEGASDLHLKVGLKPRMRVHGSLEDIPAAVLSEKKMEALVFEILTENQKQFYLEHGAFDFAHQVGPMDRFRVNIFRQRGYTSLVARHITGDIPPFEKLNLPQVVQDLAAKSHDGIVLVTGPTGSGKSTTIASMLDYINRHRPCHIVTIEDPIEYLHQDHQATVNQREIGIDVADFDLALKSLMRQDPDVVLVGEMRDHETITAAMRAAETGHLVFGTLHASNAAQTVQRILDLFPQEERELARSTFGNTMRAIISQQLLKGIKPDAKRVPAVEILISNPTMKKLIAEGRENDIPSAIRGGRGEGMQDFTDSLEKLVAGEWVELEEALRCAPNVEELKMALKGVRASSGGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL1</accession>
    <name>A0A1U9NPL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase A</fullName>
            <ecNumber evidence="6">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">chiA</name>
        <name evidence="6" type="ORF">STSP2_02636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.14" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02636"/>
    <dbReference type="EnsemblBacteria" id="AQT69446">
        <property type="protein sequence ID" value="AQT69446"/>
        <property type="gene ID" value="STSP2_02636"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02636"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="6"/>
    </dbReference>
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</entry>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="1"/>
            <end position="156"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="191" mass="20666" checksum="F6A0D375C1FFD9CE" modified="2017-06-07" version="1">MKVLGINGSPRKGGNTEIMMRKVFEPLEKAGIDTELVQIGGKPMRGCTACGKCREMQNGTCVITNDALNDILAKMREADGIVLGSPTYFADVTAEMKALIDRAGYVSKNNGGQLQRKVGVAVAAVRRGGSIHAFDSMNHFFQISGMFIVGSTYWNMCYGREVGEVENDEEGIANMADIGESMAFLLEKLAK</sequence>
</entry>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A1U9NPR0</accession>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="166"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AQT69922.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20563" checksum="39EB943246E534B5" modified="2017-06-07" version="1">MDAVYESALVERACGGDERAWAVLFRGHFGPVYSFVLGLVRGRVDDAEEVTQQTFITAAKKLHRFDSERGGFRAWLFGIARNCCRKHVSKRSPVVYDSQTVEAGADRGDEFSHKRLVLETLARLPGHYRTVLEAKYFHKRSVAELAAEMDASERAIESRLTRAREKFKSVYQGLAKEEFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV1</accession>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <dbReference type="EMBL" id="CP019791">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18167" checksum="2C8DEE4E4F5B4CF4" modified="2017-06-07" version="1">MTGTEWKELRALTSEADTGPAVDAIDWDTMLATGRVKPGHVNAYKSGGLWFFRAYGKGSTGDTIRMAVWAARQEGGDFALVFVAKFTLGATPVPGMSGYYFAEAVTIEYQPWPRDVVAENGEHYVMGTGATANAGVATVAVDSLEAARLIGFMESVSGATEWAAEFAQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ8</accession>
    <name>A0A1U9NPZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03213"/>
    <dbReference type="EnsemblBacteria" id="AQT70012">
        <property type="protein sequence ID" value="AQT70012"/>
        <property type="gene ID" value="STSP2_03213"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03213"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
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        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="171"/>
        </location>
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            <begin position="183"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40151" checksum="EEC25FE9E6D780A7" modified="2017-06-07" version="1">MGAAVWDRERFNNITEVVSRGAAGFLGIFTLLNVAAEYLIEGFDANRWWIDFRPMPNAVSVPVLAVFSVLLLAYAILPRMSGTRRRITVFLCFVMLLVVIANIWQFYYLVINKRIEAGCYIPFSSFVAIGMAVVLLGLHNKNADTQNAWCILGTVVTVLVCSALFTVGQMVCFGSTDYRRHADAAVVFGARAYADGSCSQALSDRVVTACKLYKANLCDVLIFSGGPGDGDVHETEAMKRLAVQLGVKEDHILLDRNGLNTRMTVANTVKMSQAYGYDEIMAVSHFYHLPRIKMSFQRAGFDVYTVPARHTHGLRDMPFYMAREMAAMLYYYIEPLGELVRGKEKGPADATTGPWVNETNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ54</accession>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="119"/>
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        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16462" checksum="8EE57FC8CE5A1578" modified="2017-06-07" version="1">MEITEVRVKLVANKDDRLKGFCSMTLDNDFVVRDIKVIEGTNGLFVAMPSRKMSDHCPQCGGKNHLRAKYCNNCGAHLPEERVKQDSKGRLKLHADIAHPINAECRKRIQDAIVKAYEEEVEKSKSPDYRPVNMDTDDYDVPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ57</accession>
    <name>A0A1U9NQ57_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
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        </location>
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        </location>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="761" mass="85945" checksum="8A7FFC683E908C8A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ75</accession>
    <name>A0A1U9NQ75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deoxyribonuclease YcfH</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycfH</name>
        <name evidence="1" type="ORF">STSP2_03084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03084"/>
    <dbReference type="EnsemblBacteria" id="AQT69884">
        <property type="protein sequence ID" value="AQT69884"/>
        <property type="gene ID" value="STSP2_03084"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="29181" checksum="C3252BFF79521E03" modified="2017-06-07" version="1">MQLIDTHAHLTFPEIETQVEDVLARSREAGVDRWITIGTDPEQIEKTIELARRHDNMWAAVGVHPHHASEVDQPHLDRIRELAADPKVVAIGEAGLDYHYELSVRDKQKEVFRAQLQIAADTNLPIVVHTRKAFEDSMEILDEFAGKLKNVVIHCYSGTPEQTQQVLDRGFYISFTGIVTFKRTDDVREVAKMVPLDRMMIETDTPYISPEPVRKQKPNEPALMIHTAKLLANLHGLPLETFAQKVTATSEKFFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC8</accession>
    <name>A0A1U9NQC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="7" type="ORF">STSP2_03017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03017"/>
    <dbReference type="EnsemblBacteria" id="AQT69820">
        <property type="protein sequence ID" value="AQT69820"/>
        <property type="gene ID" value="STSP2_03017"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03017"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17955" checksum="5D1C99254DA589F5" modified="2017-06-07" version="1">MQDMMPISFTGREKLFEDLEKLEKDAVETRQRVAEAREEGDLKENGAYIYGRQNLGFIEGRMGEIRAKINHSQPRDCTEVSCEKAGFGTVVTVRNLDTDQKIIWQLLGPYDADLTEDSISILSPVGEALVGLKVGDKVSVEVPRGELQFEMLDIGKSEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD0</accession>
    <name>A0A1U9NQD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012979336" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="15755" checksum="51EACBB54638E1A3" modified="2017-06-07" version="1" precursor="true">MRNYILCLTVFSLAVFAGCAQKVQRYGSVIGVKEDKLDKYKELHANPWPEVNSKLKDVNIQNYSIYLTQFPDGKYYLFSYFEYTGDDFEADMAKMAADPTTQKWWEETDPCQLPLANRPEGTWWKNMQEVYHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG1</accession>
    <name>A0A1U9NQG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxide-responsive repressor PerR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">perR_3</name>
        <name evidence="3" type="ORF">STSP2_03353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT70149"/>
        <property type="gene ID" value="STSP2_03353"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03353"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="19016" checksum="A688847BE2517DF3" modified="2017-06-07" version="1">MPISPLNYSRHSNNYLVDTMTNASSQNDFTHKCNAKGIKVTPQRALIYKILSESKLHPSAEQVYKDLTEFFPNASLDTVYRTLKTFADAGIVECVESFGPPARYDANTASHHHIHCINCGKILDIDKSELGEFDVPQSFIKKYCIQRKRLLLEGICLPCQKDAPAENLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ6</accession>
    <name>A0A1U9NQJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">glyQS</name>
        <name evidence="9" type="ORF">STSP2_03090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03090"/>
    <dbReference type="EnsemblBacteria" id="AQT69890">
        <property type="protein sequence ID" value="AQT69890"/>
        <property type="gene ID" value="STSP2_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03090"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="9"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="488" mass="56454" checksum="E590113E1365A5A8" modified="2017-06-07" version="1">MAKLTKLDDIVSLCKRRGFIFQSSEIYGGLASCYDYGPLGSELKRNVRNAWWKSMVQMRDDVVGLDSSIFMHPLVWKASGHADKFADLVTVCQKCNTRSRVDHLTEGAEEHTEHIDPELAAKDAKNLDKKVCPACGAVGKFSAPMEFKLMFQTEMGANVDDQMKVFLRPETAQGIFANFRNVLDSTRVKVPFGIAQIGKSFRNEVTTKAFIFRTREFEQAEMEFFCEPGTDEEWYKHWKEQRFQWYVEYGIKKENLRFRDHDPDELAHYAKACVDVEYKFPFGQGDWQELEGIANRTDYDLRQHQRGMRTINDWYENGRDLTKVTLKEEAEDYHKGPLSFFDDQEKKRYIPYVIEPSAGIDRSTLAFLVDAYDEEEVKGKTRNVLRFHPAIAPIKAAVFPLVKKEGMPEIAGKLSNDLKKHFACFYDEKGAVGRRYRRQDEAGTPYCVTVDGQTLEDDTVTVRERDSMDQQRINIDQVKSYLRENLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM6</accession>
    <name>A0A1U9NQM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03437"/>
    <dbReference type="EnsemblBacteria" id="AQT70231">
        <property type="protein sequence ID" value="AQT70231"/>
        <property type="gene ID" value="STSP2_03437"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03437"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013318927" evidence="1">
        <location>
            <begin position="30"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="574" mass="63528" checksum="9ED265A67286D0CB" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN8</accession>
    <name>A0A1U9NQN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03240"/>
    <dbReference type="EnsemblBacteria" id="AQT70038">
        <property type="protein sequence ID" value="AQT70038"/>
        <property type="gene ID" value="STSP2_03240"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03240"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011453">
        <property type="entry name" value="DUF1559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07596">
        <property type="entry name" value="SBP_bac_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31375" checksum="D303C866F755D685" modified="2017-06-07" version="1">MNLKKGGFTLIELLVVISIIALLLAIMMPALGMVKERARRVTCGSNLKQVGISMLTYATDNNNKVPPSWMEENWRGTAGYAGWAAYFACHINPNATSDQDKIIGDPYNMTWLITTDYLKDPKVFYCPSARTVSKTYSYEPYIGRLSWPFVKNPPGNSNSAAVRVSYSYIPQVRAREVIQCGSSNRDVKVHMVGYKVSNMTSSTSLAADLIDTQNTVMHRAGVNKPAGINVLHGDGHVVFSNDKEAINADDFWGDSQDRPNLPNQNGYNLRALLGLFKGTAQILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY5</accession>
    <name>A0A1U9NQY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III (Xth)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03342"/>
    <dbReference type="EnsemblBacteria" id="AQT70138">
        <property type="protein sequence ID" value="AQT70138"/>
        <property type="gene ID" value="STSP2_03342"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03342"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="545"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="781" mass="88301" checksum="2AF2538B36D397CE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ8</accession>
    <name>A0A1U9NQZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lptB</name>
        <name evidence="14" type="ORF">STSP2_03558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03558"/>
    <dbReference type="EnsemblBacteria" id="AQT70352">
        <property type="protein sequence ID" value="AQT70352"/>
        <property type="gene ID" value="STSP2_03558"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03558"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
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            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
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            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
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    <sequence length="254" mass="28385" checksum="F0069143FF3512FA" modified="2017-06-07" version="1">MDMTLLETRDLVKNYSGRTVVNGVSISVEQRSIVGLLGRNGAGKTTSFRMTIGMVVPDGGTVIFEGQEITKLPMYKRARLGMGYLSQEPSVFQRLTVKENLMAILETMSVTKKERKHKAEALIERFGLTEVINSQARVLSGGERRKLEIARAMVTNPSLVLLDEPFSGVDPIAVEELQAEIQRLVDSGVSILITDHNVERTLEVADKAYIMDHGKVIAEGTPKQIIQDELVRKSYLGHTFRGDEFDDREYSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRS7</accession>
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    </protein>
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        </lineage>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="28"/>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="632" mass="68436" checksum="FA633AA191EA03F7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG13</accession>
    <name>A0A1U9NG13_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00010"/>
    <dbReference type="EnsemblBacteria" id="AQT66872">
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        <property type="gene ID" value="STSP2_00010"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00010"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01066">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="81"/>
        </location>
    </feature>
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            <end position="120"/>
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        </location>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="308" mass="34196" checksum="4EE6DA65411C831A" modified="2017-06-07" version="1">MTPKQNNNGTKANLMRRVHKHRLKTVAVLPSLITLLNGLAGFAAIWFAGDGMYMFSFHQVEISYFSVAAALIFIAMVADMLDGRIARMSHATSSFGGQLDSLCDVISFGLAPAYLVLKMMEYKLTALVNPPAELSGFLTRFIWLAAAVYLACAAIRLARFNVENEEDETSHMSFMGLPTPAAAGGLASMVMFYEGLVTTVSRDSIVFTLGEGFILFSMPFAAMMCGLLMISRIRYPHVVNQLIRGRQPMTHLLYSLVLLGLILWSLTNALLIVFWLFIFSGLFKWAHHLALRTRHKHTNTEPANTHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG42</accession>
    <name>A0A1U9NG42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66899">
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        <property type="gene ID" value="STSP2_00037"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00037"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26927" checksum="10F8FA0C04767C25" modified="2017-06-07" version="1">MGIKNIIIMSVIGLVSFAGAFGFGLLTREKKAPEQSQNQDGQVQGAGAGAMDGTTPGDGESGETIALAKNKIKEIERNLEAENPQRTMTEQQLKTLIYDVRSRLDDFKQREERIAKKEERLAVTQQELQKNIKELSDLRVKLAGAVTSLQQERQALEQTIIKVEALESQNVKKTAAVYDKMKSDQAAEVLSNMAENNQLEYAVKILYYMTERTCANALGEISRDEPSMAAVMSDKLRLIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG82</accession>
    <name>A0A1U9NG82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">rlmN</name>
        <name evidence="14" type="ORF">STSP2_00080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00080"/>
    <dbReference type="EnsemblBacteria" id="AQT66942">
        <property type="protein sequence ID" value="AQT66942"/>
        <property type="gene ID" value="STSP2_00080"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00080"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="98"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT66942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="39365" checksum="41CE10CF9F48C028" modified="2017-06-07" version="1">MDKDLKNKTLEELEQLLPELGGKKYHAKYIFSFIHTKDAAGIDEITPLSKDLRAKLKDSGYFISRLNLVEKFIDPDGTVKFLFEMADGARVESVLMKHRDRQTVCISTQAGCRMGCAFCATGKLKFNRNLTAGEIVDQVNRVAEEEGTVNNVVFMGMGEPLDNYDNSMRALHILNHHAGKCIAQRRLTISTCGIPSAIERFADEELQVHLSISLHAADDETRAKIMRIGGKYKLHELLASVRKYQARTRRRVMFAYCMIKGVNDSDQDAARVIKLLKGLNANVNLIEYNPHPGCDFQASDRNRIGRFMDLLMKAGIETTVRYKRGEDIKAACGQLGATWLDKKRSGDTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGC1</accession>
    <name>A0A1U9NGC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">leuA_1</name>
        <name evidence="11" type="ORF">STSP2_00120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00120"/>
    <dbReference type="EnsemblBacteria" id="AQT66982">
        <property type="protein sequence ID" value="AQT66982"/>
        <property type="gene ID" value="STSP2_00120"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00120"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT66982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="617" mass="67818" checksum="46E4C5CEBBB8268C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP5</accession>
    <name>A0A1U9NGP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67111">
        <property type="protein sequence ID" value="AQT67111"/>
        <property type="gene ID" value="STSP2_00252"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00252"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11955" checksum="57C708019069FF0E" modified="2017-06-07" version="1">MYRNEMVRHVRQKVIRGELSAGDVAVMSLEELGQLFERGSVSMADSECIKRHAVSADGVRRSMQPIADVSNQLEGGSRAWFRENYPDAVYGVDGQVVTINLAGVEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS7</accession>
    <name>A0A1U9NGS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ORF">STSP2_00082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00082"/>
    <dbReference type="EnsemblBacteria" id="AQT66944">
        <property type="protein sequence ID" value="AQT66944"/>
        <property type="gene ID" value="STSP2_00082"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00082"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="364"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="444" mass="49366" checksum="F96159C22A0CA04E" modified="2017-06-07" version="1">MRVIIAGAGEVGTYIAERIAEEQHDVTVIEIDMDRAEELSNTLDVHVVCGSASSIEVLKKAGVEKCHLFLSLTSDEEVNIVSASVARKLGSDKTIARVDNPVFRQYPKFSYQNHFGIDEMFSPKMFAALEIASFIRNPGLLAVEYFAQGTVVMRPVKIDESSRYIEKKLIDLNIPSDVRIACVTRGTELIIPAGDTILKADDNIILIGETEKVSEFQKKFKSGKTNARRVVMLGGGRIAKSLARRLKPSDFRLTIIEQNAARCETLAHELPSATILQGDGTKLDLLMEEHVDTADFFIPTTDYDEVNIMSALQVKNLGAKKAIVLIHRPDFVHLIEDLGIDHAVSPRAIMAREVLTMLKKGKERSLADMGAGDAEILELHFKNEKLTGSELKDITLPENSLILLIKRSDKVIVPSGDTKLEQNDVLLIICRWRDSKKLMRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU2</accession>
    <name>A0A1U9NGU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadB</name>
        <name evidence="13" type="ORF">STSP2_00295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00295"/>
    <dbReference type="EnsemblBacteria" id="AQT67152">
        <property type="protein sequence ID" value="AQT67152"/>
        <property type="gene ID" value="STSP2_00295"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00295"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="26"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="445"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="538" mass="59360" checksum="36EF72D5406F32C1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX5</accession>
    <name>A0A1U9NGX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mnmE_1</name>
        <name evidence="6" type="synonym">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="10" type="ORF">STSP2_00322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00322"/>
    <dbReference type="EnsemblBacteria" id="AQT67179">
        <property type="protein sequence ID" value="AQT67179"/>
        <property type="gene ID" value="STSP2_00322"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00322"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE_helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="461" mass="48868" checksum="FB6A344AEB31F798" modified="2017-06-07" version="1">MYELSETICAVSSADVGAGEVCKSILRISGGDAREVVGAVVDLKRELEGRGIYRGVIGVGEFLRVDAEVYFFAGPASYTGEDLAEVHFFAAGAVVEAVFGRMLERCRMAGPGEFTLRAYLNGKIDLSQAEAVAEIVAGGNLAQVDAAQRLLAGKLCDTVGGLREEILDVLSLLEAGMDFSEEDIEFISADDAGGRIGKVRDELEGILGKAIRYEEAISLPSVGLVGRPNAGKSSLLNRLVGSERSIISEQEGTTRDVLTGVVEFGGMRCVVFDCAGIEEVKAGNVIDEWAQEAAVEAIRGAELLAVCVDMGRADYAEAVEVPGVGVAKRRIVVGTKMDAVSEGEREERLGRLREVCGCAVVGCSSVSGEGMEDVLKAVRGELLAEGGAGREDMVSINERHRQTVEKAVKALGDAADEIGSGNEEICAMLLRDAYEVLGGIEREDVDEGVLDRIFGRFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ2</accession>
    <name>A0A1U9NGZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66870">
        <property type="protein sequence ID" value="AQT66870"/>
        <property type="gene ID" value="STSP2_00008"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00008"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6799" checksum="17506519F26A3FEB" modified="2017-06-07" version="1">MNAFDLISVFLYVQFLVLFILSLKCKPPEGKHAKLLVKMAWFLIAGTVILLIQSLFRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH09</accession>
    <name>A0A1U9NH09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein STSP2_00352</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00352"/>
    <dbReference type="EnsemblBacteria" id="AQT67209">
        <property type="protein sequence ID" value="AQT67209"/>
        <property type="gene ID" value="STSP2_00352"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00352"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="194"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="441" mass="46141" checksum="38E85A13503652F1" modified="2017-06-07" version="1">MNTQNQYTLKDILKLEVAPALGCTEPAAVALATAAASSLLDAGRITSIQLWLSANIYKNAFAVAIPGTDGATGIDLAAALGHTGGDATQRLQVLAPVTGDHITAARELIASGSVEVNLLKEAPTIYIKAAVSTAEHTATATIEHTHDNITELTLDDKPLAEHPLLASISDSKSSLAELEDFLRTQTFEQLITLVETMDEEDFEFIRQGVEYNLKLARHGLSFGPGLGIGKTLDRLVREGLIKKDMIQAARILTSAACDARMSGAKLPAMSSAGSGNHGLTAILPIWAVKNYINETSDHEALKAVALSHLVTGYIKSHTGRLSAVCGCSIAAGAGASAAITYLMGGNLNHIASAIKNLICDLAGCICDGAKASCAFKLATAAGSAVQSALFSLHGINVKESDGIIALSPEQTIKNTGELSTQGMIETDRTILKIMIEKTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH24</accession>
    <name>A0A1U9NH24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chemotaxis protein PomA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pomA</name>
        <name evidence="10" type="ORF">STSP2_00038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00038"/>
    <dbReference type="EnsemblBacteria" id="AQT66900">
        <property type="protein sequence ID" value="AQT66900"/>
        <property type="gene ID" value="STSP2_00038"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00038"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT66900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27370" checksum="0BE4555F861B1C4E" modified="2017-06-07" version="1">MDIATVVGVLAGFALIIGAILSGGSLKIFVNVPSLLIVVGGMLCSVLIHFSLGQFLAIFAVIKNAFFHKAHSPVILIQQMVNFAAINRRDGALALEQEMRKVDDPFLVKGLQALVDGQEEDDIRALMGMETEYMQARHGDGKKILEFMGASAPAFGMVGTLIGLVQMLQNMSSPDDIGQGMATALLTTFYGALLANLVFIPMAGKLGQYSKSETLAMEMITEGVCAIVRGDSPTVVREKMQAFVSASKRADVKVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH37</accession>
    <name>A0A1U9NH37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67068">
        <property type="protein sequence ID" value="AQT67068"/>
        <property type="gene ID" value="STSP2_00208"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00208"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010701777" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="16622" checksum="EB354DD1357D386F" modified="2017-06-07" version="1" precursor="true">MMKKLMVLALVLGIGSMAAAGLSVVAPEEIQVGDTVTVQIVSDDGLQYDGYISVDLGGAAVWSGDDTMTDITVPASTTTFYGTYGDGSFWAFTNSDTSVTDALTPGTGFEFGLTGAAEGTATLTLYNSGFSPISTSTVNVVPEPMTLGLLGIGGLFLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH59</accession>
    <name>A0A1U9NH59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RIP metalloprotease RseP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">STSP2_00402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67259">
        <property type="protein sequence ID" value="AQT67259"/>
        <property type="gene ID" value="STSP2_00402"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00402"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="122"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="24735" checksum="DAC3ED850B46F221" modified="2017-06-07" version="1">MDISLGLAWYVVFVLSASFHEAAHAFTAMKFGDRTAYQGGQVTLHPIPHIAREPFGMIVVPIVSFLFNGWMIGWASTPIDPYWAGRNHKKAALMSLSGPASNLLLILVSAALIHIGIAAGFFNQPSISELGFSTIVTADAGTLANGAANMLSICFSLNIVLTTFNLLPVPPLDGTAIVGLFLDRATAEKYQSFIHQPGIALFGLIMAWMSMDFIFPPVYALAVSFLYPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB2</accession>
    <name>A0A1U9NHB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">STSP2_00465</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67322">
        <property type="protein sequence ID" value="AQT67322"/>
        <property type="gene ID" value="STSP2_00465"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00465"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21544" checksum="1A2496D9F3C2E59D" modified="2017-06-07" version="1">MNFDLNFLLSLLPGLVVGLTIHEASHALSAKWLGDRTAEKMGRISLNPLDHFSPTGFLAFFLLGFGWGKPVIVNLYNFKKPRFHYLLTSLAGPASNLLVACISLALLYLHPTGMLRNALKSIFLINCLLATFNLLPIPPLDGSKIWPCLIPGMKPAFSGKTNLIWVGVVIIGLYSGAVDRIITPVLTFVHSLIPALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF4</accession>
    <name>A0A1U9NHF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67339">
        <property type="protein sequence ID" value="AQT67339"/>
        <property type="gene ID" value="STSP2_00483"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00483"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17281" checksum="E59B9740F00ED3B9" modified="2017-06-07" version="1">MTQNKKLPLSLRIVAALFILTGISGILEMIIGLFQDEFILNIGGILALLTGLGLLKLSSGWRSFALFVLWFYMIGIPAMLVFCAISDNDKMQIFNKEIVNPPLLYDLAFMVPLFLIVLWMYHILTRPNVRKLFIPSEQTTKLQSDPTLFDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR2</accession>
    <name>A0A1U9NHR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trxA_1</name>
        <name evidence="3" type="ORF">STSP2_00281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00281"/>
    <dbReference type="EnsemblBacteria" id="AQT67140">
        <property type="protein sequence ID" value="AQT67140"/>
        <property type="gene ID" value="STSP2_00281"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00281"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15757" checksum="60945EB40B0E6449" modified="2017-06-07" version="1">MKEQTRNTLIIFAVVAAVLGVLILKQYNQQQFVTELRGDEIVGAGKPAMLELGSHECNACKEMMPVIDELAKRYGEKVAVGFVDVKAEESYQEKYDLSRIPTQIFFDGEGNEVFRHIGFYPLEDIVEKWAELGVELSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR8</accession>
    <name>A0A1U9NHR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="4">2.7.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lacC</name>
        <name evidence="4" type="ORF">STSP2_00460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00460"/>
    <dbReference type="EnsemblBacteria" id="AQT67317">
        <property type="protein sequence ID" value="AQT67317"/>
        <property type="gene ID" value="STSP2_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00460"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="16"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33493" checksum="AA9E784D9C8ABAF8" modified="2017-06-07" version="1">MFTNREIVTVGISPCWDITCRVKGIDWGSHETIDAQYSVPAGKALNVSRALAQLDIPSTATGLWGSDDYQQMLSTIAQLSENITPDFVAVPGSTRRNITIADTFNQREMHLRSPSTLANPESLDRLEQKLLSLASENKLFVFAGSLPTGELLERIATIIEKLHQAKAAVALDTSGPALRTLVEAGHVSIIKPNIEELSELTGAQLSDDPHQLIASTKPLLEEVDIVLLSRGAGGAIAITREGSVSGAFRGKAQPVTHTVGCGDYLLAGFLTGLTQVGESGFALQRGLLTATARAFGVKPTDLSLANQIELKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR9</accession>
    <name>A0A1U9NHR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00196"/>
    <dbReference type="EnsemblBacteria" id="AQT67056">
        <property type="protein sequence ID" value="AQT67056"/>
        <property type="gene ID" value="STSP2_00196"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00196"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012617680" evidence="2">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48360" checksum="F4B4CC4BE246453E" modified="2017-06-07" version="1" precursor="true">MIAGKKLAVTVLVTIIAATAIAEIETRPMFDQPPAPKAQQPEKFPYIGKVTGQNVYVRSGPGTAYYFSDKVSEPTTVTVVSSVHDIWLKILPTEDAFSWISADYVRKSPTDSDTGIVTADSVRVYAGSGFIKPQHSSSFQTKLNEGEKVNILGPVTDGYYKIEPPEGAFYYIAKRYVDFVRSLAPETEEPADEEAEPADEQPTDEEPADEAAQPADEDTDEQAEPAEEDETTEPADEEPAEGEDQAKVPTEKTYVLEVQEIARQVEQIHSKPLTEQDYSEVRTQLKEIADNPKAGRAVEYAKYLLDRIDNFELAIRAGQLVERQEQALERKRRQIRAEYQKKLQMIPQNDDFIATGTLRKSAVFTTETGQQRYLLIGDNKRIIAYAVPATPINVSTFVGKEVGLIGDLVPVQGQSIPLIKFIELKVIEPKETTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS1</accession>
    <name>A0A1U9NHS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphatase YtkD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00291"/>
    <dbReference type="EnsemblBacteria" id="AQT67150">
        <property type="protein sequence ID" value="AQT67150"/>
        <property type="gene ID" value="STSP2_00291"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00291"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="24010" checksum="D2382AB19391DB92" modified="2017-06-07" version="1">MKFDWFHIAKRLKAISQAGKFFAKDEYELGRHEEIEEIAAKVLERHTDLDAEEIVRLLQKDMGYPTPKVDSRGVVFRDGKVLLVKEIEDGGWTLPGGWCDVGMTPSENVVREVWEESGFLVEAKRLLAVYDRDRQGHKPEYVFDIYKMFFLCEIVGGEARTSIETSDVRFFGRDEIPELSRGRTLEHQLEKFFDMYESGEWVTDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW3</accession>
    <name>A0A1U9NHW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hppA</name>
        <name evidence="11" type="ORF">STSP2_00667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00667"/>
    <dbReference type="EnsemblBacteria" id="AQT67519">
        <property type="protein sequence ID" value="AQT67519"/>
        <property type="gene ID" value="STSP2_00667"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00667"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387306" description="Putative K(+)-stimulated pyrophosphate-energized sodium pump" evidence="10">
        <location>
            <begin position="24"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="826" mass="85570" checksum="F7155CC5A026426D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX9</accession>
    <name>A0A1U9NHX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67210">
        <property type="protein sequence ID" value="AQT67210"/>
        <property type="gene ID" value="STSP2_00353"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00353"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="21320" checksum="6BF6EFE2D155998E" modified="2017-06-07" version="1">MNQPASNGPTISFDEFGPLEIRPQPGRNYCHTDHPKRLPATYTRKHGVQHWLAFYDVHQKKLWGYVRPRKRHQEFLEVLKLTRKKYPANQRIHLILDNFSPHRKEKVLRYCRENNIHLIWTPTNASWLNPIECQFTHVKEFVIRGTNYQNHNELKIALNRYVAYRNKKNQQKLNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI04</accession>
    <name>A0A1U9NI04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67551">
        <property type="protein sequence ID" value="AQT67551"/>
        <property type="gene ID" value="STSP2_00699"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00699"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="36940" checksum="015C88F6A15502DF" modified="2017-06-07" version="1">MGKWFLIGADWYLMICTRRASLFIILVWLVCASATIAGLENGSFELTAEPNSVPDFYPPLSWEHENYAAVVEEFIPNPNQRNESAINWPDKYFEVGLQPLDGEKFLLLSTGDVEPDVSQAKVSQQIEALPGQTLQGWFFFGTFDFEPYSDQAHIILKKEGDPNYSTGVLLAGLDVSELPEAEDYDTTVDVGTYGSMQGWQRFSHIFTEETAGSYELEISVTDIQDKWYRSYLAVDALQLCQAPFEGDLNFDCYVDLQDYAIVADQWLCDCTDPNNLPDPNDCPWEMTDDGSIIADLEGDIDGDDVVDPNDLQIIQDNWLSGEKPKTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI39</accession>
    <name>A0A1U9NI39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">addB</name>
        <name evidence="6" type="ORF">STSP2_00413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00413"/>
    <dbReference type="EnsemblBacteria" id="AQT67270">
        <property type="protein sequence ID" value="AQT67270"/>
        <property type="gene ID" value="STSP2_00413"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00413"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125852" checksum="AEB087F9772D5F10" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI60</accession>
    <name>A0A1U9NI60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">STSP2_00759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00759"/>
    <dbReference type="EnsemblBacteria" id="AQT67611">
        <property type="protein sequence ID" value="AQT67611"/>
        <property type="gene ID" value="STSP2_00759"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="556" mass="58681" checksum="C2BD534F28E646F8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI75</accession>
    <name>A0A1U9NI75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease III (Xth)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00777"/>
    <dbReference type="EnsemblBacteria" id="AQT67629">
        <property type="protein sequence ID" value="AQT67629"/>
        <property type="gene ID" value="STSP2_00777"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00777"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="29639" checksum="71500D064216E1DD" modified="2017-06-07" version="1">MAGLTKRVFLVAGILAVGLLGGCAVPGNGDSKSVRVMTYNIHHGEGADGVLDMDRIAEVIEASGADVVGLQEVDNNFGARSEFVDQAKYLAEKLGMYYAYGPAIRYGGKDGERLYGNALLSRYPIAGTENHLLAKFEGHEQRACLKARVELAGDTYAVLVTHLDHKSAELRDEQAKGLIEIVGEQPERTILMGDFNCPPPGTEAGDKQSVNAVARIIKTLDPACSIGGGPAEATVGSGVKIDYIFVSDDIASNVVDCGPVRNDVTAKASDHLPVVAELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI83</accession>
    <name>A0A1U9NI83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00581"/>
    <dbReference type="EnsemblBacteria" id="AQT67434">
        <property type="protein sequence ID" value="AQT67434"/>
        <property type="gene ID" value="STSP2_00581"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00581"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="315" mass="34196" checksum="31B42B8B08E4320A" modified="2017-06-07" version="1">MYFTAVINSLIPIIMLLGVGAAAHKLRWLNRNSEDQMLRLIINVFIPCLIFASITDEATDTSAGLIAELFAWGFAMPLVGIMISLAVGWFVFRDQPSTRHTFATCSGMHNYAYIPLYLIGSLFGQQVVGLVFIFTSGVELCLWSVGVTVLSGKFDRNCWKKIINPPLISLIVALLIKNAFDANPVPVPVQKFFSSAGAVAIPLGLLISGSTLAERLQHVRFTDRSLLKTAVAGSIIRLAVMPLLVLTVASFAAGHVQTREILIVQAAMPAAMFTLVLSRHYKGEPVTALVIIATTTLLGFATIPAWVALGQKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI88</accession>
    <name>A0A1U9NI88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thermophilic serine proteinase</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67226">
        <property type="protein sequence ID" value="AQT67226"/>
        <property type="gene ID" value="STSP2_00369"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00369"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07484">
        <property type="entry name" value="Peptidases_S8_Thermitase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034084">
        <property type="entry name" value="Thermitase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013115385" evidence="6">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="141"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="479" mass="51862" checksum="F41059EB81CC9BD2" modified="2017-06-07" version="1" precursor="true">MIKRIWIAAVLLICSAVLCPHTLAAGKGKPEWVKGEFIVKFKPGMARSQVKSMTHKHGSEILASSRFSRFQRLKVPQGRTAAQMVEIFRKRPEVEYAELNYIARAFASPNDSYYYLQWNFSDPYRGINAEAAWDITEGDPGTIVAVLDSGVAYEDYGSFQQAPDLASTSFVSPYDFINNDAHANDDDGHGTHVAGTIAQNTNNYSGAAGIAYDCSIMPVKVLDDIGEGTYSAIADGVYHAANNGAKVINMSLGGSGYSTTLRNAVQYAYNNGVTIVCATGNEYNEGNPTTYPAAYNSYCIAVGATRYDRTRAPYSNTGSYVDLVAPGGDLDVDQNNDGYGDGILQQTFAEGDPTDFGYYFYDGTSMATPHVSGIAAMLISLGITDPDDVREALESTARDLGSTGKDNQYGWGLVDAYAALDYYRSMGDFNADGSSDMDDLAMLIENWLTSDGYADITPETGDGIVNFRDFAVFSQLYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA3</accession>
    <name>A0A1U9NIA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagO_1</name>
        <name evidence="7" type="ORF">STSP2_00807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00807"/>
    <dbReference type="EnsemblBacteria" id="AQT67659">
        <property type="protein sequence ID" value="AQT67659"/>
        <property type="gene ID" value="STSP2_00807"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00807"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="38657" checksum="5FCE4A630D47677D" modified="2017-06-07" version="1">MATVIVGIVVGVCGFLVSAGGTVLVRRGAVRRDFVARPVADRYHRTIIPLGGGIAIFWTMALLLGGGLAVTAWAEVLGLEKILGEGLMVHREGFLDTAGVLGVVLGCAAVLHVMGLVDDVKGLGWGVKLGVQFAAAFAAAYFGDVRVELFIESRVVTAGLSAFWIVLIINAFNFLDNMDGLSAGIAFIATGVLLVAAVYSEQFFVGALAIAFMGALGGFLWHNFPPAKIFMGDAGSLVVGFFVATLTLKTTYYHEETGGGLYAVFMPLVVMAVPLYDFISVTVLRISQGKSPFVGDTQHFSHRLKRRGLSDVQTAGTLYLATLCTGIGAIFLWQVDIAGAVLIFAQTVMILAIIAIMEATGKGNAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF2</accession>
    <name>A0A1U9NIF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">rnfD</name>
        <name evidence="11" type="ORF">STSP2_00504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00504"/>
    <dbReference type="EnsemblBacteria" id="AQT67360">
        <property type="protein sequence ID" value="AQT67360"/>
        <property type="gene ID" value="STSP2_00504"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00504"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="350" mass="36305" checksum="0DFA3AC7F5996556" modified="2017-06-07" version="1">MHENLTVSPAPHISKAHSTQSVMLDVLIGLAPAVIAAIIYFRIEAAAVIITCTIACIAAEWISNKMLRRPSSIGDLSAVVTAVILALSLPPTIPLWGAAVGSAFGIFIAKMVFGGLGANVFNPAMAARAFMAASLGGLMTTWTVPATVDAQLATNEPAAMAKISAANEVAEDGTTEAITQATPLAWSKNAQKGEVDASIVNKLIEATFTGTTGGCLGETSSLALILGGIYLLIKRTISFHIPAAVLLSAFAAAAIGWFAAPEQYANPVFHITSGGMLICAFFIATDPVTAPLTKLGMWIFGIGVGVVIMLIRLVGEYPEGVMYAVLLMNAFTPLIDRFCKLTPAGGKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ7</accession>
    <name>A0A1U9NIJ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">STSP2_00470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00470"/>
    <dbReference type="EnsemblBacteria" id="AQT67326">
        <property type="protein sequence ID" value="AQT67326"/>
        <property type="gene ID" value="STSP2_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00470"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23956" checksum="D49690C9F9583FD1" modified="2017-06-07" version="1">MAKRLVLKGQTRTETGSKQAKRLRDQGLVPAIAYGHKEEPISIKLNCHDLTEALHHGHRLMDIEVDGKLETVIVKDLQYDHLGKGIIHADLMRVDASEKVNVTVAIEAKGTAKGTLEEGGMLQIVADTIDINCPAEDIPEVIYYNVEDLEIGDAFHANELPLPEGAELVSEPETTLASCIMTRVEEEEEEEEMVPGEIPTEPEVITERPAEEETEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM3</accession>
    <name>A0A1U9NIM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">resA_2</name>
        <name evidence="3" type="ORF">STSP2_00928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00928"/>
    <dbReference type="EnsemblBacteria" id="AQT67779">
        <property type="protein sequence ID" value="AQT67779"/>
        <property type="gene ID" value="STSP2_00928"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00928"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010729225" evidence="1">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="33672" checksum="C143403CE09EB96E" modified="2017-06-07" version="1" precursor="true">MSAKKLTFAFITALFVFAPITIADGKVGEKAPDITVRQWLTPNSPDVKNLQGSPYVVEFWATWCKPCVKNIPHLVELNKKYRDSGLKILGLCQDKAPREINKLIRKNKIDYHVAIDNGSADWFAIRAYPTVMVVDHTGTITWRGLPWRSGFEKAIKAAIEKAPPQFLADIDLGPFADHKQALKGGKNFTKAYYDINHYASETDGSSKSRLAKKIVDRIDTGLQKQLDKAAKVSGSDPVTALCIYDQIARRYSGITPAIRAKILKRQLTENLHKQQSENKELAFFYNTARTTSNQSRESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ9</accession>
    <name>A0A1U9NIQ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ORF">STSP2_00776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00776"/>
    <dbReference type="EnsemblBacteria" id="AQT67628">
        <property type="protein sequence ID" value="AQT67628"/>
        <property type="gene ID" value="STSP2_00776"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00776"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27743" checksum="A81D6F909C83B644" modified="2017-06-07" version="1">MRNKDIAICLRTVDYSETSQIATLFCREAGKISAIAKGSRRKKSSFDGPLEIFTYGDVIYTLPKQDGSLATLIELDQRPVFVGLRHRLYTMNCALFAAELTNKFTQDFDPHPDLFDNFVQFLQDLRTSEDETAAIRLLVIFQLTLLSDIGSGLILSRCANCSAPYSSTWPRIYFTSQAHGIVCPDCEISYPDKIRLSRTSAACISDLQKFKNADPDRVREIERLLVRHFTELLHKPPRMAKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU8</accession>
    <name>A0A1U9NIU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67668">
        <property type="protein sequence ID" value="AQT67668"/>
        <property type="gene ID" value="STSP2_00816"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00816"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28897" checksum="8A003979C871EC88" modified="2017-06-07" version="1">MSSQTKPAPKQRKHPILRYSFIAVLLLVIASASGFLLLTWQSDKYEPAPPRRTERVSTFLTHDIAETWYNSVQNGKPFELIVQQKNINDVIANESQLGFKWPIELDGAQISTPAVLFEPGQVTLMAPVQIGKVPVMISILSKPRVDDEGLLTLNVESVKAGMVNITPLARKFASGMIKKQLESTDLGPEEAWLTDIADALLDNKPIEPCWPSHDDYMVRLLKTDIADQQMQLEFDPYKADSDPALAADNKKRTTPSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW5</accession>
    <name>A0A1U9NIW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01025"/>
    <dbReference type="EnsemblBacteria" id="AQT67873">
        <property type="protein sequence ID" value="AQT67873"/>
        <property type="gene ID" value="STSP2_01025"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01025"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22114" checksum="16372BF6D60B720A" modified="2017-06-07" version="1">MAGGNTLHASFGHDRYMFRRKVFKVFGGAFHVYDPAGGVAFYGEQKAFKLKEDLRVYADERLGEELLVIKTPQILDWGATYYVQDGATGVGVGALRRKGLKSMFKDEWVYMDAAGNEVGRLAESSLLGALLSRQTNLMPQTYRIALNDGREVARIKQHFNPFILKYTMDIVNGDGEIDRRLLMASGILLAAIEGRQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY5</accession>
    <name>A0A1U9NIY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00832"/>
    <dbReference type="EnsemblBacteria" id="AQT67684">
        <property type="protein sequence ID" value="AQT67684"/>
        <property type="gene ID" value="STSP2_00832"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00832"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843868" description="TGc domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="386"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="485" mass="54032" checksum="33FF6C60ACC36A40" modified="2017-06-07" version="1" precursor="true">MTRQIILAILTFIVISPLLPAAENTPAGSEKQTHYYKLLFDGHKVGHMVKTRHISDGKITNTTETNYIMTRLGTDTKVIEKEKIVETLTGKPIAFEYEQSSGGDVRRNIGTVDNGVMNIKTISTSRTTTRRIPLPEDTVMDEGLFLHIKNNGLTRGDTFTVHMFEPLFQDAVPMKVRVGEEQEIEAEGKNLRATRIDTLMKCSTAAMPYTAYYANEDFKLIRDVSPQMGMKMETAICTRGEALSENEKYDIIERVLIPSPTWLKDLSRKTTAKYVIKPLTDRKLHFHAGPRQSVMRKADGTTIIEVSKAEMTGGTFPYDGDDSDLLDALKASTYIQKDDEKIKELANKAVTDCETAAQAVKEIERFVYSYVSENDLSIGYASAAEVARTGLGDCTEHALLATGMCRAAGIPARVVMGIVYMQKAFWLHAWCEAYVNGQWVGLDPTHPTGWNIGHVAFGKGDGDPADYMGMYRSIGYFKIQSIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ07</accession>
    <name>A0A1U9NJ07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00955"/>
    <dbReference type="EnsemblBacteria" id="AQT67805">
        <property type="protein sequence ID" value="AQT67805"/>
        <property type="gene ID" value="STSP2_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00955"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="343"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="54332" checksum="E2B1AF98BF4F61C5" modified="2017-06-07" version="1">MAYRYGDRYQRSLFPQSIDDYVPADSPVRAYDAFVDSLDFDELGIEINTGKVGCPQYDPVSMLKLLLYGYSYGVRSSRKLEREANYNISFIWLTGGLKPDHKTIAEFRRKNRGALKKVLRQCARLCIKLDLIKGNTLFIDGTKVRANASNKNTWTKEKCQRRLKSIDKRIKQILSECETVDRKEVNQGSWIKMDEELSDQKKLRSKVESIMEQIQAEDSKSTNMTDPDCKMMHSIQGSHSSYNVQSAVDDENGLIVNSDVVSDNHDYKQFADQVDKANDTLDNDCETACADAGYSSVDELEKIDEKGIEVVVPSKKQAEKKKKDDNPFDRSKFEYDKKNDCFICPEGHVLKYSYTNKTKKAKVYRGGAACRKCRHFGKCTDQQRGRSVSRLLNADVQEKLEARYEQPRAQEVYKRRKQKVELPFGHIKRNLKVDSFLLRGLEGVRAEASLLASCFNVARMMSLLGVERLISTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD4</accession>
    <name>A0A1U9NJD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01196"/>
    <dbReference type="EnsemblBacteria" id="AQT68042">
        <property type="protein sequence ID" value="AQT68042"/>
        <property type="gene ID" value="STSP2_01196"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01196"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007380">
        <property type="entry name" value="DUF438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04282">
        <property type="entry name" value="DUF438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF438" evidence="2">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="29175" checksum="C265C5E414E18E65" modified="2017-06-07" version="1">MARTYKNSDVLTSLLRRISRGEDPKTIKSEASKLVTEVQARDIAEAEQNLINDGFSVRLAQQLASVFLLIGMLDEKSLSLRKELPADHILRMVIAEHDIMRCFIADLEDVTEEIQHLALLTDTQTEFRKFTHIIEHLDSIEEHIQREEDVIFPSLQKHGWTSLCQAARNDHVYIRIGLSDLIKLIANFNQIPFSQFRAQLNSATSFICPLLRDHFFQEETILFPIAVELIKDETVWKRIKQACDEFGYCGIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH4</accession>
    <name>A0A1U9NJH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67957">
        <property type="protein sequence ID" value="AQT67957"/>
        <property type="gene ID" value="STSP2_01109"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01109"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="189" mass="22439" checksum="3E7865B290A59C9F" modified="2017-06-07" version="1">MMIVSFYTADTPYEQEVGKLRKSLEAFDLPHKIYEIPSKGSWQKNTHRKPHVILRALDELDEDILYVDADATLHGKPQIDLAGFDWAAHIMDKAYWGQDTSKRTHSLMSGTLCFANNRRSRMILELWIQLNRQYPWRWDQRNLELIWRKNQERFLNLPVEYCAIDKTMTVENAIIRHHQASRRLKGRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ1</accession>
    <name>A0A1U9NJJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67908">
        <property type="protein sequence ID" value="AQT67908"/>
        <property type="gene ID" value="STSP2_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01060"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="38764" checksum="5B37092C8E443AAB" modified="2017-06-07" version="1">MGFRDQEKQRYAQLKSSLFSEAAQPEGVYRNIPRTFCLPEECSSENLHMSIRKDALDYFRRRNIPWHDGFADTEGKQKALPSNHLCCSQSMCVNSLFPMTRDKRLFERVFRVFFPELKEALTFEADQEDGENAVPYLCFEFVGEKTHFEGERSWPQRGANCTSLDFAFLFEQFDGKRHLVLGEWKYTEEYLRCKLPTAGDYNKTRLATYKEDFHKSQLNHGKLPNYTDYFVEPFYQLMRQSLLASKMQAAGELGADIVTHLHVSPKANRQLAYTFTSPEFAAHGATVFDAWKKLVGPDTFCNIHSENLLTAIEQCCSNDWSHWLLKRYGWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL1</accession>
    <name>A0A1U9NJL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proclavaminate amidinohydrolase</fullName>
            <ecNumber evidence="5">3.5.3.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pah</name>
        <name evidence="5" type="ORF">STSP2_00844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.22" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00844"/>
    <dbReference type="EnsemblBacteria" id="AQT67696">
        <property type="protein sequence ID" value="AQT67696"/>
        <property type="gene ID" value="STSP2_00844"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00844"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033972">
        <property type="term" value="F:proclavaminate amidinohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="32183" checksum="4A113B2CB44BB99A" modified="2017-06-07" version="1">MTDRKQFGDWHDNNSEPNGSSIVLIPVPYDETSTWQKGADKGPAAIIDAAYQLERYDIETDSEVYKRGIWTDNPIQCDPDPFRMVQQVRDRTAFWLADNKHTVVIGGEHSVSVGAIQAHAEKYENLSVLQLDAHADLRDEYEGSKHNHACVMARASEIAPCVQVGIRSMDASEKQLMDPDRVFFAEEIYNRREWANDAVDILTDQVYITIDLDVFDSSIMPSTGTPEPGGMTWYEVLRFLRKVAETKNIVGFDIAELCPNPQNKAPNYLAAKLIYKTLSYQFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL8</accession>
    <name>A0A1U9NJL8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rsgA</name>
        <name evidence="7" type="ORF">STSP2_01169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="YjeQ_EngC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="102"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
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        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="202"/>
            <end position="210"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="40345" checksum="EAC13CCBCAF05088" modified="2017-06-07" version="1">MIDLRELGWNEFFEKSFEPYRAKGLRAARVVREHRKGYLVCTGDSDVEAEMAGKIAYRAKSKAEYPTVGDWVAVRELRDEGRAFIEAVLERKSKFSRKSAGLSEDEQVVAVNIDTVFLVTDAWQDFNIRRLERYLVLGWDSGARPVVVINKSDLCEDTGKYVEQVREIAPEVDVRCVSAIEGDGIAGLKEYMGSGETVAMLGSSGVGKSTIINAILGMERQEVKDVRAEDGRGRHTTTHRELIVLPEGGAVIDNPGMRELHMRTDERGLGRAFDDIQEIAEECKFRDCMHENEPGCAVKAAVEEGRLDEERLANFFRLREELELWERRDSEKLSRGQVRKRIKHQARRARRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR8</accession>
    <name>A0A1U9NJR8_9BACT</name>
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            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        </lineage>
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    <reference evidence="4" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
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            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21197" checksum="4DBA53B1DF53F82B" modified="2017-06-07" version="1" precursor="true">MKKILVIAVAALISLPCISFAGPTANFDQIDFSAYQLLYSINAGVDNTDLAGVGVTSSVYSDGSEYVYAYQLFNQSDVTLENFVVPDFPGIIQGSLAYTTMALPFEFDSNIDVVPFYAEVAAGDSVQFEFNSAFAFSDLAPGTTSAVLLVKSTDEWTTRQAIVQNGETGTVDVVAAVPEPTSIALLSFGTLVLTRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS7</accession>
    <name>A0A1U9NJS7_9BACT</name>
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        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">STSP2_01222</name>
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    <reference evidence="5" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="274"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="521" mass="55026" checksum="FE4AA6B644468F99" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW8</accession>
    <name>A0A1U9NJW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68034">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26673" checksum="24E428CB357BA298" modified="2017-06-07" version="1">MDRKAGIGLLGVLLGLSVGLNMMLIGIFNELAEGENKAASAVFIGETMDSVLNWGENRIEIYSQEHEEIEVHETGEWEFVIVPLKGRHRGEKGLGRLEVINHGEAFRAICFTLVHCDAAAGRKGLELLREIDPEFDVSLLWYEGGDRKHRRVSIDEICELGRNEPAGGYSTRDAVGDGASQFEWEAGRYGYFLSDEKKYVVMEAEVPVKGAVVPIEEAPREVREQVRRRDGAGVTDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK24</accession>
    <name>A0A1U9NK24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68259">
        <property type="protein sequence ID" value="AQT68259"/>
        <property type="gene ID" value="STSP2_01415"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01415"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17781" checksum="44EA207C0C655753" modified="2017-06-07" version="1">MNDDVVFEDMFRSTLGQPINYKDKTLVLVDSMSVNDGEHIRIVFETTDSEWKQGISLVIEDGSIVVAGKEVKDKRGIGLWEDTAPKAVELVTKTGKKPISRLNIHNVWHNGRFIDYGHNGAAMWVEEIPNGRRYHCNDGHPDDDLNDLVFRIERMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK28</accession>
    <name>A0A1U9NK28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01322"/>
    <dbReference type="EnsemblBacteria" id="AQT68167">
        <property type="protein sequence ID" value="AQT68167"/>
        <property type="gene ID" value="STSP2_01322"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01322"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030180" description="Lipase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="341" mass="38150" checksum="EF8D1AB2B9546FEF" modified="2017-06-07" version="1">MRYAAVLFLVCLAAPAVLADFDEEKARQNVIKWLGDIGLEDELGAGVNVETDESGLLSIVDEGHYLLQYGLLTPARSADAEVTISDELKIKPTAKNFVIVVHGWFDKGEGDWPEDMAGAFYERTDPNSWVCGYFDWQGGAAVATPMDAARYSCDVAGPRLAKALLSLPNEIEHVHLIGHSAGSWAIDTAAERIARKTGATIHLTFLDAYVPPKWDKSLLGHVSSARDGRVYVEHYYTRDITYECTHEDLARACNVDITDIDFGIKEHEFPYRWYRATAAGEYLKSEMEYGQAVVFNQDGVAYGFARGLEAGKKSWKQSLKLVDRETVMIRKPKRKSKWKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK77</accession>
    <name>A0A1U9NK77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polysaccharide export protein Wza</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01478"/>
    <dbReference type="EnsemblBacteria" id="AQT68319">
        <property type="protein sequence ID" value="AQT68319"/>
        <property type="gene ID" value="STSP2_01478"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01478"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956673" evidence="3">
        <location>
            <begin position="32"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="500" mass="54027" checksum="5099FD97595F65CA" modified="2017-06-07" version="1" precursor="true">MNLSCYKKIKTLCLCVFTGFFAVLISGCAESDSKMLSTPEQLEMFHAAGPIKTEIDVEQLMQAKVSLDEYRLVQGDMLEFQMPAVLAKTDVQIESEQFFIHRTRVASDGTIQIPVIGQVHAAGKTLVELEKTVTDAFYPRYARNKPAIVANISQYQKAKVSITGAVENPGVYSLRSDQMSLVSLIMEAGGVVEDGAAVIKIFNPGARTAKVGGPEGIVITAAQMPDSKQVQFSFVSQAGGSKGVLKLKRGGELIFSDLLDVAKAEDREGFIGEVTSQFNDIPKSFVSKRLNALAQAVAPDSVDTEEANPKHAAVKEDTLPTAAKPIEEEPEKTKKDHNTKTQDTAGKVRKLTLPVKGLNVPFSDVALQDGASVEVEALNPETFTVIGLVKKAGAFPYPANVNYNLLQALAFAGGVDPVTDPRYVRVYRQDNDGQVVDATFKLNDTLPASGASVSIKPGDVVSVEHTPRTRRNMLMAEILGVRLGVGATYNMIDGKDLRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC8</accession>
    <name>A0A1U9NKC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68267">
        <property type="protein sequence ID" value="AQT68267"/>
        <property type="gene ID" value="STSP2_01425"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01425"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="3">
        <location>
            <begin position="384"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="508" mass="58061" checksum="F394310F594FCBD6" modified="2017-06-07" version="1" precursor="true">MGRSMDRRKFLKISALGVFGVSAGLAGKLAYAAEGRQAKKPNLVYVFPDEMRGSAMGFLGEEPVITPNLDRFAQASLVLPEAVSNYPVCVPYRTIMMTGKYPFGNGVLVNCFCDGRDLPKGQKWWTDVLDEKGYSIGYYGKWHITKPMREYKGHKLKGQEGKWLPPDRRHGIDYWRIHTTNNHLKNRYVSYDRPCVGGVKVREVWTPEFETDCAIDFIRNEAGKYRKEDQPFALVLSYNPPHSPYQVVPQKYVEMYDQDVEQYCGGVASVPGADERWGKYYRRNIRQYYGAITGIDEQFGRILDCLKEQGIEDDTIVVFTSDHGNCLGRHGHVSKNVPEDDSMRVPFIVRWPGKVKAEHDDLLISTGDIYPTLMELMGTADGCPDDLEGQSWAKIFTGGEQERPSSQLYMHVKEPEGDERYGRRGVRTHRYTLNIEKMPGNAVEVLLYDRKSDPYQVRNIAGERYDVVERLIEKELRPWQAKIRDSFVLPDLGFLKEGQVRGPVVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF5</accession>
    <name>A0A1U9NKF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyglutaryl-CoA dehydratase, D-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68214">
        <property type="protein sequence ID" value="AQT68214"/>
        <property type="gene ID" value="STSP2_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01370"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30554" checksum="0A6F7D2E9B4732C3" modified="2017-06-07" version="1">MAVVGYTSGYVPVELIEAAGHEAKFVRPSMAGGAECLRLREGMCPYAAGTVASLLGRDDLDAFVGAGTCDQVRRCFEAMRDEFGGEMFVLNVPVTRGTASQGMFGAEVERLERFLKELKDSTNDDEVLEDGRDEQRTRFEDGSGELVLGVIGAPIAAEGLMLGEIAGARLVDMMGPVRLGEFGGCESDMDGLVRKYFVEVLDIRQRSNAGWYEWLREWSGSGAVDGLILHRYTWCDLWHGELGRIKEAAGVAVIDLEINEAGSYASANTVTRLNAFGEMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH8</accession>
    <name>A0A1U9NKH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">resA_3</name>
        <name evidence="3" type="ORF">STSP2_01607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01607"/>
    <dbReference type="EnsemblBacteria" id="AQT68443">
        <property type="protein sequence ID" value="AQT68443"/>
        <property type="gene ID" value="STSP2_01607"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01607"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572548" evidence="1">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23831" checksum="E726365015C2298D" modified="2017-06-07" version="1" precursor="true">MNARVTVRMVILAVLSITLTACKQEAPPEASAKSAEPSGQAVNVNPGREMAEDFALLDEEGRKVRLSDLRGKIVVLEWTNYDCPFVQRHYEADTMEGLEAKYGDHVVWLAINSTHYSDTAGNKAWVEEQGLAYPVLDDHEGEVARAYGARTTPHMFVIDREGYVVYEGAIDNDPTGRGADEPVNYVDEALKRLVLRKDVEVSETKPYGCSVKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM1</accession>
    <name>A0A1U9NKM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68483">
        <property type="protein sequence ID" value="AQT68483"/>
        <property type="gene ID" value="STSP2_01647"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01647"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21357" checksum="91F76EB29451B275" modified="2017-06-07" version="1">MYCKKVRSKLNTMLDTGRQPDSVIKTHLQSCDSCSQYYRQLLNIHRDLTLEQPDRTTNNNTGSVKMGVLNALDKNEGSTHKIRSANLNIHHHIKKAALATVAACIAAIILVNSSLITNDNANIPRPPAAQDTTSLDRVLSAGAINNFALSQVANLLSHPEKSIQNNFRTTAQTFVKEVGSITTQLSTVHQTPSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN3</accession>
    <name>A0A1U9NKN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68150">
        <property type="protein sequence ID" value="AQT68150"/>
        <property type="gene ID" value="STSP2_01305"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01305"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15365" checksum="A3A9B3BAF435C592" modified="2017-06-07" version="1">MFDWKNGFSLTFIALLSTFAVGGLFFCWVMHNLVAEGPVARVFIGLMFFFLAVLFGMNFILVPIQILYFNRKNRDDSKLKKATLADWLMLPFGACDADAKVSRWVSVPLLVVLWVLVAIFVVAVIGSVTAWVVGPTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN6</accession>
    <name>A0A1U9NKN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01667"/>
    <dbReference type="EnsemblBacteria" id="AQT68502">
        <property type="protein sequence ID" value="AQT68502"/>
        <property type="gene ID" value="STSP2_01667"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01667"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165683" evidence="2">
        <location>
            <begin position="20"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="256"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="331"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="972" mass="105717" checksum="B838F128F15276DF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP3</accession>
    <name>A0A1U9NKP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68160">
        <property type="protein sequence ID" value="AQT68160"/>
        <property type="gene ID" value="STSP2_01315"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01315"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="900" mass="100005" checksum="8234711295ACBD57" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL34</accession>
    <name>A0A1U9NL34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="1">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">top6B</name>
        <name evidence="4" type="ORF">STSP2_01700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01700"/>
    <dbReference type="EnsemblBacteria" id="AQT68535">
        <property type="protein sequence ID" value="AQT68535"/>
        <property type="gene ID" value="STSP2_01700"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01700"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006553">
        <property type="entry name" value="TopoVI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="77"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="570" mass="63894" checksum="362B3D2AADCE9632" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL52</accession>
    <name>A0A1U9NL52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ORF">STSP2_01622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01622"/>
    <dbReference type="EnsemblBacteria" id="AQT68458">
        <property type="protein sequence ID" value="AQT68458"/>
        <property type="gene ID" value="STSP2_01622"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01622"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="57618" checksum="3B52380DF167137A" modified="2017-06-07" version="1">MLKKRASGILMHITSLPGRFGIGDFGPAAYKFVDFLRESGQNYWQILPLNYTSPEMGNSPYSGFSAFAGNPLLISPELLYRQGLLNRSDLTPVPDFSKTAVDYEAILGYKTRLFDAAFERFTPDADFEEFVQSNSYWLEDFALFMTLKQEYGKKKFNAWPAPIRNRRSGAMNKAKKEHAQQLRKECFLQYIFAHQYDQLKTYCNDQGIQIFGDLPIYVTYDSADVWAHPEVFKLRKDRKPEMIAGVPPDYFSETGQLWGNPVYNWDTLRKTRYDWWMRRIKYNLSLFDMLRIDHFRGLEAFWEVKANAKTAINGQWTPGPANHFFDELFRQIPQAALIAEDLGYITAEVRELINDYNFPCMKVIQFAFDSEDGDNLHMPHNHTRNSVVYTGTHDNNTTVGWFNTELQEYQKKLLSDYAGTKINARNVHWQMIRLAMASTSKIAITPMQDVLGLDADQRMNCPARPEGNWKWRLPARKITPALTEKLHRLTRIFGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL87</accession>
    <name>A0A1U9NL87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB_3</name>
        <name evidence="6" type="ORF">STSP2_01875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01875"/>
    <dbReference type="EnsemblBacteria" id="AQT68703">
        <property type="protein sequence ID" value="AQT68703"/>
        <property type="gene ID" value="STSP2_01875"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01875"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuvB_N" evidence="5">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB_C" evidence="4">
        <location>
            <begin position="251"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35735" checksum="5927E8F3DC2318A9" modified="2017-06-07" version="1">MTANQPPKQKQKQPWPTLSDVSGRPGAVSALQQLSSIPDSRSPSSTGILICGPRGTGKKFCARAYHNSLGNHHLYLAAANSIETGDLYRFMLCRDHHDRSTLLIDNAEKLKEPLQLMLSTALSQAFIQSPNVPDARSYSLSVEPFTLILTATDEHNIIDRLKQNLCTSLQFDHYQANTLAEIINDYFHRNGLKLEHPQLTRQIADRSKNSASIAIDRIANTAVEKVRAEDRDLITAFDVAQTLRELKIDSLGLDETDRSLLKILELKESASISEIASSTRLDIEDLSERSEPFLLKTGLIKKTHGRLSITDKGCIHLKNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL90</accession>
    <name>A0A1U9NL90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68595">
        <property type="protein sequence ID" value="AQT68595"/>
        <property type="gene ID" value="STSP2_01763"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01763"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11480" checksum="BD39F69F126CDBE3" modified="2017-06-07" version="1">MSSKRKNTRSRGYVAVDYVTVAFAEDRELARQYEELLAANGISAAIKKQDGTEFGSYAVLVSEENLEEAHYMIESERSMDTLFDISFGDDAFTDLEADTDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE1</accession>
    <name>A0A1U9NLE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68554">
        <property type="protein sequence ID" value="AQT68554"/>
        <property type="gene ID" value="STSP2_01722"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01722"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13587" checksum="8DC137FEFFF398AE" modified="2017-06-07" version="1">MTPQTRFIIKGAVAGFILGCIFFGHTFETSTQPETLRVFTEDGQLIQSLTYETLVRTLVISPSGILFGGGALAAVSAFIAFLVIESWSGITYRELFKKLTAHTVFKRIVRSKSNEKVFFKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF3</accession>
    <name>A0A1U9NLF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68772">
        <property type="protein sequence ID" value="AQT68772"/>
        <property type="gene ID" value="STSP2_01944"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01944"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="10057" checksum="6E7B94CDDD35D147" modified="2017-06-07" version="1">MALQNNSNSNEKTWPARPKNFPDLMTPTEAAMFLRLDQTGHTPKSAKRTLNYWRDNGFLNATKYARRVWFLKQELEKFLHKKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI7</accession>
    <name>A0A1U9NLI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68667">
        <property type="protein sequence ID" value="AQT68667"/>
        <property type="gene ID" value="STSP2_01836"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01836"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16750" checksum="6A7940856767EB29" modified="2017-06-07" version="1">MDVFSSLFSFSPMVVEQLMGELKESLPEDGLFVVIRDEDGNWWSSEESESGAVSEFGGELELLCGRIADGYDPVVCELGDKIAAGRQLEGEEITCGYVFVMVDRDQVGSAEGVNSLIEMVLNQICMGVRLIEKNNRLHHDRLKQMSGGKAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP8</accession>
    <name>A0A1U9NLP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">STSP2_02037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02037"/>
    <dbReference type="EnsemblBacteria" id="AQT68861">
        <property type="protein sequence ID" value="AQT68861"/>
        <property type="gene ID" value="STSP2_02037"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02037"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="470" mass="52330" checksum="EB434803F62C3115" modified="2017-06-07" version="1">MGKPRVQLYYKNVTADIIGRKHGINAEQFQELANQTKPVISELNQMRESGQVAYRDLPYNEDYPRQVKEIAGELEGKYENFVVLGIGGSALGNIALQTALNPYMYNLDEKQRAGRPRLFVFDNVDPAQLASFLNWVDDKLDKTVFNVISKSGRTAETAAQFLTIRNVLLEKLGEKGYREQVVATTDSKQGTMRTITDDAGFKSLEVPDGVGGRWSVLSPVGLLSAAVCGIDIDELLEGARSMDERVKTEDFFKNPAAINAAVNWNYYNCGKRISVMMPYSYNLKDMSDWYRQLWAESLGKSKDLRGHDIFVGPTPVKALGTTDQHSQVQLYREGPNDKLFTFLQVNEFENDITIGGNPDCAPELGYLGGAKMSKLLNSEKIATEYALLKDKRPCMTVMFDKIDAHAVGEFIYLFEVTTSLAGLLFGIDAYDQPAVELGKEATFALMGREGFTDMAKDISPVAEIDDSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU0</accession>
    <name>A0A1U9NLU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02070"/>
    <dbReference type="EnsemblBacteria" id="AQT68893">
        <property type="protein sequence ID" value="AQT68893"/>
        <property type="gene ID" value="STSP2_02070"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02070"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17723" checksum="0C66E5B1C49DB991" modified="2017-06-07" version="1">MEEKKTFEIVTHGPSETMEIGAKIGESLRGGEVICFVGNLGTGKTHLIKGIARGLGAEDTGVNSPTFVLVNEYIGEGVRLDAYHIDAYRLESVKEFEMLGFDELCYPDSVVMIEWADKVESYLEGLDYVEARLEHEGESERKIILKNLPGYLYEVLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM05</accession>
    <name>A0A1U9NM05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemE_1</name>
        <name evidence="2" type="ORF">STSP2_01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68764">
        <property type="protein sequence ID" value="AQT68764"/>
        <property type="gene ID" value="STSP2_01936"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01936"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="342" mass="37686" checksum="18D92F9945C848A8" modified="2017-06-07" version="1">MNGKERIEKVLQGQWPDQRPVMIHNFMMASREAGISMAEYRSDPKKIAQVHIQAVEKYKLDGVFLDIDTCTTAGALGVPVVLPENETARTTGSHPDLTSLDAVADLPAPDIANDERVQIWVEACRLLKEYFGDEILVRGNCDQLPFSVASMLRGMTEWMMDLMNPESQEKVFQLLDYCTIACEQFVRLMADAGAHLLSHGDSPAGPDMISPDMYVKYAMPYEKKIIDLVHKLNKYYLLHICGDTSAILKDMVATGADALEIDYKTDVNLMHQVCGDCITISGNLNPAGALLSAGPDGVAQEVRDLLNIYNDSPRLIVCSGCVLSPETPAENIDAFVKTVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM12</accession>
    <name>A0A1U9NM12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68526">
        <property type="protein sequence ID" value="AQT68526"/>
        <property type="gene ID" value="STSP2_01691"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01691"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30495" checksum="C41CDA569D0076A0" modified="2017-06-07" version="1">MARKQRKIGYTLTELLVVIAIIAVLVAIGVPAVKSIQESFNSGSNVKTVISKALGNARAIALKEQTYAGVRFQRARDGRQYMVLVIYDPGATELDANGFRAVPGRKPNKLPEQVLVLDGYSNIVREKKGFKVVVKEEHRGGDNEAFDENVELNETSTFSVVFGPSGRLIARSVRVRNREGIPNTESNDQLSDDKIFNKKAAVESGAALFYQDGYCLTGADYSPDLGYGPETSRKSFIVCDRLAFEKVPPTMRWTRYLRNAENVYINSYTGEVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM15</accession>
    <name>A0A1U9NM15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68847">
        <property type="protein sequence ID" value="AQT68847"/>
        <property type="gene ID" value="STSP2_02023"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02023"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="29452" checksum="1A0D6F1F74013041" modified="2017-06-07" version="1">MISLKQAENTLLAYSQSMFPKMLLGVLSPGGKIPKYIKNGSLPICVMCKQLVRDPNYCQQFYNSCDFNRHGTVRCPFGVHLEYVASEHTKQPLAFFVQKSFTETSLLREFEKNLPRKKKKIFKRAKVESRDKKCEFREHALFRLLQVGETLLAGRVAAPMRALSHQLLTPVQAVMSDLKFFRYQRKSDENEEAEEILQLMNDNVAEINSITKQIHILLSEELSPSPQSIRRVTDLPPNYVPASVRELSFSSVVYCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM73</accession>
    <name>A0A1U9NM73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">panD</name>
        <name evidence="14" type="ORF">STSP2_02187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02187"/>
    <dbReference type="EnsemblBacteria" id="AQT69009">
        <property type="protein sequence ID" value="AQT69009"/>
        <property type="gene ID" value="STSP2_02187"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02187"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014004014" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014004011" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT69009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12611" checksum="88E9244A30464881" modified="2017-06-07" version="1">MLSKALKGKIHRATVTGTKIDYPGSVGIDADLLEAANIKPYEEVLLANVTNGERLGTYCIPAPAGSGEFTVLGAAARHFSVGDIVIVMNFAYYTDEEMDSLKPSVVVPDENNKIAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM83</accession>
    <name>A0A1U9NM83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmolarity response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02020"/>
    <dbReference type="EnsemblBacteria" id="AQT68844">
        <property type="protein sequence ID" value="AQT68844"/>
        <property type="gene ID" value="STSP2_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02020"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21489" checksum="3D8C5C9D248DB2FC" modified="2017-06-07" version="1">MYADLENALKRYGREADLRKAIRNARICIIDDQIDHLKSFVRGLNDEGFTNLVQKTHIESINELLENDYDLIVLDLQGVADGISADDGIGVIASLKESDPAMPILVVSGTNTSPDKSKIINQADLIRIKPVLPGDLASDIEDILKNRKSQYWGALAVLKELHKIKPEVTCPRIMYQLLLESCPSHLSCIAVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD4</accession>
    <name>A0A1U9NMD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68995">
        <property type="protein sequence ID" value="AQT68995"/>
        <property type="gene ID" value="STSP2_02173"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02173"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="39567" checksum="42E5B20F07E7CD3E" modified="2017-06-07" version="1">MVLYFSVFWLSCRPVLYIMLRDITPKPVRLFAAKHIFPKSPVIWANFRPIVQLCTNRLKPQEPPVVILSLPRSGSSWVGEILGGAGDALYLREPLTQTYLRSGGEKKLSFFEFDGPPWEYEKAADLSFRAIPQFSKGIVRFPEQWGLNCRTRKKTVIKEVNPFVLPWLMQKYQPRIIYLVRHPASTAHSFHKMGWDGRNQFERRFLDRSLAEINDYQRWAGSFWSAHAAVQSVVLKRVLEQAKGYESFKLVQYENLCKDPINEFRSLYDFAGLKWDEAAEDLVVKKTQPSQVDKHSFSTQRNSAVEAEKWRKLVSADKLELIKEAWLWYDPPLYRDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ8</accession>
    <name>A0A1U9NMJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68820">
        <property type="protein sequence ID" value="AQT68820"/>
        <property type="gene ID" value="STSP2_01996"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01996"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="467" mass="52823" checksum="AB5954D1F928A8B4" modified="2017-06-07" version="1" precursor="true">MNRRDFLKQCAVTGIAGSISSAASGAGAQLGNKTFNLRLGKRRYNVLFVFVDQWRFCSLGHGPNHDPDVITPNLDKLAKQGAHWSRCYATHPVCTPNRSAVITGRWPWQTGMNQNDLMLPPEERCIAQHFTEAGYKSHYIGKWHMDGNAKPGFVPQGWRRRGFTTFEGFNRGHFYFNSPTFTNDGDMMRDIGLYESGDYEPTLQADLAIDFMRNNQKNPFFCFVSWGPPHGPYTPPAEYDIYNASEMTYRPNVPDDKVGNTRQEGYFGSITALDHEFGRLMKSLKDLDLEDDTLVVFTADHGDMIYSHGLSYKGKPEEESWHIPLLMRLPGKIDSGQITDTLISTADLMPTVMSLAGLDDPTTCTGIDKTQALNGGHMPDASVYGGVQDRWRAVVKGDHKLIVEQIDGNEVATRMYNLSTDPYEMTNIINETSVQTVKDDLWAEYLQWKDKTQDSFPEYPWLAENMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU0</accession>
    <name>A0A1U9NMU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kbl</name>
        <name evidence="3" type="ORF">STSP2_02097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02097"/>
    <dbReference type="EnsemblBacteria" id="AQT68920">
        <property type="protein sequence ID" value="AQT68920"/>
        <property type="gene ID" value="STSP2_02097"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02097"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="394" mass="43554" checksum="BCB43583A8D45A05" modified="2017-06-07" version="1">MFGAMKDHLNSELQKIKESGLYKSERIITSPQDASIEVKSGQKVLNFCANNYLGLADNPEVIEAARESFDKWGFGLSSVRFICGTQAVHKDLEAKLTEFLGTEDTILYSSCFDANGGLFETLLTAEDAVISDQLNHASIIDGIRLCKAQRYRYKTCDMADLEEQLKQAQSARFRLIATDGVFSMDGTIAKLDKICDLAEKYDALVMVDDSHAVGFMGEKGRGTHEYCGVMDRVDIITGTLGKALGGASGGYTSARKEIVEMLRQRSRPYLFSNTLSPTIASASIKVLELLSRNTDLRDKLWENTNYFRSQMSSLGFDIIAGEHPIVPIMLGDAVVAQKMAEKLLEKGIYVIGFFYPVVPKGQARIRCQISAAHSREDLDYAVKQFAAVKEELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN63</accession>
    <name>A0A1U9NN63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylose isomerase-like TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69275">
        <property type="protein sequence ID" value="AQT69275"/>
        <property type="gene ID" value="STSP2_02464"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02464"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013205480" evidence="1">
        <location>
            <begin position="23"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="59"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="3">
        <location>
            <begin position="289"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="54052" checksum="773F7A0E31A98170" modified="2017-06-07" version="1" precursor="true">MKKNMAIMIVGVVAIMACNLMAAGPEMPLKEHPAVSAYDGWRLGTQAWSFNRFTFYEGLDKTRSLGLDYIEAYPGQKLSKDGDGKFHHNMSEELRKEVKQKLKDAQIKVVNYGVVGLGNDEAKAREVFEFAKDMGIETIASEPPFEAFDMLDKLCQEYKINLAVHNHPKPSRYWNPDTVLKVAEGRSDYIGACADTGHWVRSGLDPVECLKKLEGRIKSLHFKEIKDGHDVPWGTGAKRAPKLLEELHRQGFEGVFSIEYEYNWSNSVPEMRQCVAFFEKKGRELNPTGWEPLFDEDFANADMKEGSWEWKQGVLTRMGGGDIWTKGKYSDFVLDMEYKLAPKTNSGVFIRTQDHNWLPWIEVQVEDSHGKEIDRHVAGGIFDVLAPSKNAVKPAGKWNRMTIGAKDNKVYVVLNNEPIIDMDLNDWDEAHKNPDGSKNKFNVAYKDLPREGFIGLQDHGQAVWYRNLSIKELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN77</accession>
    <name>A0A1U9NN77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase A1</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">chiA1_2</name>
        <name evidence="7" type="ORF">STSP2_02542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02542"/>
    <dbReference type="EnsemblBacteria" id="AQT69353">
        <property type="protein sequence ID" value="AQT69353"/>
        <property type="gene ID" value="STSP2_02542"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02542"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_II"/>
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        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
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    </dbReference>
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        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160476" evidence="5">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="383" mass="42475" checksum="E34A2D70D3B396C2" modified="2017-06-07" version="1" precursor="true">MRKILITAILFSLLLQFARPTALTAATQPASDFYGSFQVVGYYPDYWWTPIPDLRYDKLTRVIFFSIYPNIDGTLNTSEIDPNRQAELLSDAHQNNVDVSICIGGWGLSDNFSPVAADPATRTAFVNNLLQYCLDHGFDGIDLDWEPVSTATDRANYTALIAELKAAMLPHDLTLSVAVFAAGSEFYSSAIDDIDYLHIMAYDMSSDPSLPHSTCEGAVQAVKHWQSFGFPNSKIILGVPFYGRDGSWTYYSYKQIVQQYSPPPDVDEVAGIHFNGIYTIKAKTKYVMDNNLAGLMFWELTQDTNDHISLLTAMTDQIHASSPPDLNTDGNIGLQDLAHFASNWLSTGCSTANAWCANADLNQSRTVDFADLSIFSHHWPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA9</accession>
    <name>A0A1U9NNA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02413"/>
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        <property type="protein sequence ID" value="AQT69224"/>
        <property type="gene ID" value="STSP2_02413"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
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        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="32078" checksum="4954F8D43E54F2E6" modified="2017-06-07" version="1">MADKAEFVRLVGTERRVGPTLESVSRHWQGKEECALFVSPHDDDAVLGGGLLMRLLEEENVPVYIIITTDGRMGYCSKEEQDEIVEIRKKETFDCYQALGVPKENIIWLGFPDCNLNAHKGRKKAEGEGPTTIGGYTGLQNSFTYWLRKINPTQCFLPTDNDLHPDHRVVYEEFMISMFHAAGDIWPELGPALPKVPYVHEMAVYCDFPEPPTLRITTPESILEEKLAGIGKFVSQKQIASLIENVRKGGAQEYIRAVGFDLYVPSNYYHRFEHRERIVDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND0</accession>
    <name>A0A1U9NND0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69399">
        <property type="protein sequence ID" value="AQT69399"/>
        <property type="gene ID" value="STSP2_02588"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02588"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13033" checksum="0E87A0E3119070B1" modified="2017-06-07" version="1">MKKTSIFFPLIIIGICLSLTGCQDQTQSISERQARLVASQNMQLKAQLEQKDAEIANLQEELEDCRGQIAKMEEASAAAAGNMMEMIKSSTESLTKQNIELRAKVKELEAKLAKESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND8</accession>
    <name>A0A1U9NND8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pdhD_1</name>
        <name evidence="16" type="ORF">STSP2_02443</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02443"/>
    <dbReference type="EnsemblBacteria" id="AQT69254">
        <property type="protein sequence ID" value="AQT69254"/>
        <property type="gene ID" value="STSP2_02443"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02443"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="341"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT69254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="49188" checksum="8B588DF6E3239D5F" modified="2017-06-07" version="1">MADSFDVIVIGGGPGGYAAAIRCAQKNANVALVEKAEMGGTCLNRGCIPSKALLGSAHFLTLAKHARLMGVDIEKPSPNWTKMQARKDAIVENFSKGVKTLVKANKIKLYEGIGIAKGPDTVTVQTDNEEVELKAKSIILATGSVPVEIPAFKFDRETIISSKEALNLSEIPESLVIIGGGIIGCEMACVYATVGSRVTIIEALDQLLPNEDAWVGKIMQREFKKLGIKCLTSQKVTGVDVNNDTAKVNLESGESIDADKVLVSVGRRAICDQETIEALGLEMQGSTIEINEKMETSVPGVYAIGDAVGTTYLAHGAFQEAEIAAENSLGGDEKMGDYNLIPKAVYSFPEVASIGLNEKKCTKKGIDFTVGKAAFRSNGRSVAHNETVGEIRVIRETDSNKILGVTMVGATVTEMISTARALIGTTEDITDVCFAHPTVSEVLKEAWEDAFGISLHVPPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH0</accession>
    <name>A0A1U9NNH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rd</name>
        <name evidence="9" type="ORF">STSP2_02683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02683"/>
    <dbReference type="EnsemblBacteria" id="AQT69492">
        <property type="protein sequence ID" value="AQT69492"/>
        <property type="gene ID" value="STSP2_02683"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02683"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5875" checksum="9DF7073F89D7E47A" modified="2017-06-07" version="1">MKKYRCLMCGYIYDPEKGDPANGVDPGTAFDDIPDDWVCPDCGAGKEEFEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM2</accession>
    <name>A0A1U9NNM2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">STSP2_02586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02586"/>
    <dbReference type="EnsemblBacteria" id="AQT69397">
        <property type="protein sequence ID" value="AQT69397"/>
        <property type="gene ID" value="STSP2_02586"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02586"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="23245" checksum="2CC6E1CFCC9B39F4" modified="2017-06-07" version="1">MSGNRIALFGGSFDPIHLGHLTVAQDSRKQLSAEKIVFIPAKRSPHKKNKPKACDRDRLEMILLAIAGSDEFEVSECELTRPEPSYSLDTVRYFRQLYGDDAHLYWLIGADAVRDLHKWYHADEFLDECSVCIMNRGGVEIPDFGPIKEALGQDRAAKLKRNMISTPSVEISSTEVRRRVRDQEPLNDLVPSEVAEFIANKGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV1</accession>
    <name>A0A1U9NNV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69398">
        <property type="protein sequence ID" value="AQT69398"/>
        <property type="gene ID" value="STSP2_02587"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02587"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14375" checksum="9DB9B5FD6652A2E2" modified="2017-06-07" version="1" precursor="true">MAKKKAAKKKAKKKKAAAKKPATKKAPRKKKATARKAASKAVAKKPAAKKAKKKAAKKKTRKKAASKTTKAAAKKKTKKKAKKKTAKKSPAKKATKKKAAKKKAKKAPKKKAAKKKATKKAAKKKKKKATRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX2</accession>
    <name>A0A1U9NNX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpx</name>
        <name evidence="4" type="ORF">STSP2_02688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02688"/>
    <dbReference type="EnsemblBacteria" id="AQT69497">
        <property type="protein sequence ID" value="AQT69497"/>
        <property type="gene ID" value="STSP2_02688"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02688"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18748" checksum="FAE5EDF74012FF3F" modified="2017-06-07" version="1">MKERSNLVTMKGNPVVLMGDEVQVGDKLPDSELVKNDLSPVKLSSYQDKILIICTVPSLDTGVCDAETRRFNEEAASLSDDIKVLTISMDLPFAQARWCGAAGIENVETLSDHKNCNFGQQVGVCIKDLRLMARAVFVVDKDGTIKYTELVPEITNEPDYDAAINAAKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY2</accession>
    <name>A0A1U9NNY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-inositol 3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mshA_2</name>
        <name evidence="4" type="ORF">STSP2_02803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69609">
        <property type="protein sequence ID" value="AQT69609"/>
        <property type="gene ID" value="STSP2_02803"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02803"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="272"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="386"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="589" mass="67902" checksum="86C37F8BB11AE960" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP57</accession>
    <name>A0A1U9NP57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">atpH</name>
        <name evidence="8" type="ORF">STSP2_02579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02579"/>
    <dbReference type="EnsemblBacteria" id="AQT69390">
        <property type="protein sequence ID" value="AQT69390"/>
        <property type="gene ID" value="STSP2_02579"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02579"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23614" checksum="4B65C5564752666D" modified="2017-06-07" version="1">MPESVRHVVREIYSEVLFELAEEAGCVDKVMEDLERVVEILQEQPEFASLLASQELKGQEKSEMVRRVFKEKISDLALDFLCVLARRNRIGFLASIFDQYEVMLDAQQNISLVEVTFAQKPKPEKLEKLKSELSDALKAKVKLRVDIEPEIMGGVIIKIGDRMIDNSLKNILGRAVNSVVENSKSKLKKSKSGFAGKKAPAVRKPNERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP63</accession>
    <name>A0A1U9NP63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xthA</name>
        <name evidence="3" type="ORF">STSP2_02898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02898"/>
    <dbReference type="EnsemblBacteria" id="AQT69703">
        <property type="protein sequence ID" value="AQT69703"/>
        <property type="gene ID" value="STSP2_02898"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02898"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="29353" checksum="5FC8AC4C8A51E703" modified="2017-06-07" version="1">MKAATFNANSIRSRAGIVLDWLEANQPDVLCIQETKVQDDHFPVKAFEDCGYNFVYKGQKAYNGVATFARGQIEDVKIGLDGDESEQARFLKVNLGGVSIVNTYVPQGRAPDSEQFLYKLEWFGQLREWFDKNFSPGEDVLWMGDLNVAMDARDVHDPEKLWGSVCYCQEVQDALKDVMGWGFTDVFRQFNEEDGLYTFWDYRVPNGFKRNIGWRLDYIMASKSMAGRCTGCWVDKEPRALKKPSDHTFLVAEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB8</accession>
    <name>A0A1U9NPB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69584">
        <property type="protein sequence ID" value="AQT69584"/>
        <property type="gene ID" value="STSP2_02777"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02777"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20282" checksum="AB31EC6D2C5D6E6E" modified="2017-06-07" version="1">MDRVLRTSSMNRDQYQKPAFTIIEVILAMLVLSIAISGAMAFRYFSMLDARKAETRMTAARIGTLLLETWRGSGGSSLFDPLGSIDPGILEINGQDAALFGGEAGVLPGNFTRLPSTSDPDYRIVLNGHNYYVTLSYQDIDTDTDGIYEIRLLNSDIRWRRDLGEGTVTQSDQAVRFTTCVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC4</accession>
    <name>A0A1U9NPC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c551/c552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69792">
        <property type="protein sequence ID" value="AQT69792"/>
        <property type="gene ID" value="STSP2_02989"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02989"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="28527" checksum="C01285829E072738" modified="2017-06-07" version="1">MIAASIHLAGRSHANQPDDNPAAHILIYTRNGKGFVHKNIDASVACLENICKTNNWTTHATDDAAVFDTDLSRFDVIVFSNTNNQAFTTDDQRSAFQTYIRQGGAFVGIHSACGSERSWPWFWANVGGKFKRHPPFQPFDIKVIDSDNPATETLPAVWKWEDECYYLDNLNPDIHVLLAADMTTVKDSKKDEYPGKVFGNYFPLAWCHQFDGGRQFYTALGHDPKHYKDKNFINHLTGGIKWALDEEAVADNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH1</accession>
    <name>A0A1U9NPH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rny</name>
        <name evidence="9" type="ORF">STSP2_02931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02931"/>
    <dbReference type="EnsemblBacteria" id="AQT69735">
        <property type="protein sequence ID" value="AQT69735"/>
        <property type="gene ID" value="STSP2_02931"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02931"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="8">
        <location>
            <begin position="341"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="525" mass="58662" checksum="D4E0372F8F03D134" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL5</accession>
    <name>A0A1U9NPL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General stress protein 16O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yocK_2</name>
        <name evidence="7" type="ORF">STSP2_02923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02923"/>
    <dbReference type="EnsemblBacteria" id="AQT69727">
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        <property type="gene ID" value="STSP2_02923"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02923"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30115" checksum="FDF436CFA34236C2" modified="2017-06-07" version="1" precursor="true">MAKKAKKTSKGKKKTAKKKAVKKKVAKKKAKKKKAVKKKTAKKKKKKAKKAAKKKAKGASMKKAGKKKASAKKKRRTKKTHLTAADLRKYRELLLIKRKELFGDVNSIESGALRTSGRDSTGNLSNMPIHMADLGSDNFEQDFALGLMDSERKLLYEIDSALQRIEDKTYGICEGTGQPIPKARLNASPWARYCVQYQEMVEKGLVEEGEMVDFGEKETDLDEETIDELEEENIYGEEGFEEDEEEDADIDVENLGEYGYEEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM9</accession>
    <name>A0A1U9NPM9_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_2</name>
        <name evidence="5" type="ORF">STSP2_02899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02899"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26446" checksum="DFE272A701FBB3D6" modified="2017-06-07" version="1">MIDVKNLRRSFGQVVAVDGISFTAEKGDVLGLLGPNGAGKSTAMKMLACFLKPDSGTASVCGYDIGKDPIEVRKRLGYLAENVPAYNEMTTAGFLKFVCDAREIKGSARKSAIDKYVPMCAIESVYHQTIDTLSKGYRRRVGLAAALIHDPEVLILDEPTDGLDPNQKHEVRDLINQMAKEKCILVSTHILEEVEAVCNRTIIINKGRVEVDSTPGKLVEEYGGSLDEVFRKITVGKTDKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP6</accession>
    <name>A0A1U9NPP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02883"/>
    <dbReference type="EnsemblBacteria" id="AQT69688">
        <property type="protein sequence ID" value="AQT69688"/>
        <property type="gene ID" value="STSP2_02883"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02883"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
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        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024786" evidence="1">
        <location>
            <begin position="22"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="229"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="902" mass="97741" checksum="5543C3F400596F7F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV7</accession>
    <name>A0A1U9NPV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69971">
        <property type="protein sequence ID" value="AQT69971"/>
        <property type="gene ID" value="STSP2_03171"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03171"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="938" mass="104032" checksum="E0196844CD3ED61F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW8</accession>
    <name>A0A1U9NPW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="8" type="ORF">STSP2_03035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03035"/>
    <dbReference type="EnsemblBacteria" id="AQT69837">
        <property type="protein sequence ID" value="AQT69837"/>
        <property type="gene ID" value="STSP2_03035"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03035"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13368" checksum="8E5E2B4D3388D1F0" modified="2017-06-07" version="1">MGIQKFRQARIRRKKRVRKKVYGTPDRPRMTVFRSGRHIYVQVIDDIAGVTLASSSTMAKGLSDQIENGSNKKAAETVGEAIAKEAIGVGIKAVRFDRNGYRYQGRVKALADGARKGGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ05</accession>
    <name>A0A1U9NQ05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase class 1</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbaB</name>
        <name evidence="1" type="ORF">STSP2_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03190"/>
    <dbReference type="EnsemblBacteria" id="AQT69989">
        <property type="protein sequence ID" value="AQT69989"/>
        <property type="gene ID" value="STSP2_03190"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03190"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37646" checksum="D710E5F35534D484" modified="2017-06-07" version="1">MSVDRIAEILGGEADALLGHKCSTVGKGQLAVPGPDFVDRAMAGSDRPVAVLRNIQTMFDHGRLGGTGYLSILPVDQGIEHSAGASFAPNPIYFDPENIVKLGLEGGCNAVASTVGVLGATCRKYAHKIPFIAKINHNELLSYPNTYDQKMFGSVRQAFEMGAVGVGATIYYGSEESPRQIEEISEAFQMAHELGMFTVLWCYLRNSGFKKDGVNYQTAADLTGQANHLGVTIQADVIKQKQPTCNGGFEAIDVGKTHPLVYEKLSSDNPIDLTRYQVVNCYMGKAPLVNSGGPSGENDLQQVVKAAVVNKRAGGAGMITGRKAFQRPFEEGVKILNAVQDVYLTEEIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH2</accession>
    <name>A0A1U9NQH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK_3</name>
        <name evidence="6" type="ORF">STSP2_03364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03364"/>
    <dbReference type="EnsemblBacteria" id="AQT70159">
        <property type="protein sequence ID" value="AQT70159"/>
        <property type="gene ID" value="STSP2_03364"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03364"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="516" mass="56519" checksum="346199F762741D26" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP0</accession>
    <name>A0A1U9NQP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70097">
        <property type="protein sequence ID" value="AQT70097"/>
        <property type="gene ID" value="STSP2_03299"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010260">
        <property type="entry name" value="AlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05930">
        <property type="entry name" value="Phage_AlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8180" checksum="6664D51E936B45C6" modified="2017-06-07" version="1">MNLQKLINAKQLGELLSLSRRQVFRLNSSGKIPAPLRIGGSVRWNSEEVHAWIDNGAPARQQWEAMRTAGGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR4</accession>
    <name>A0A1U9NQR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69960">
        <property type="protein sequence ID" value="AQT69960"/>
        <property type="gene ID" value="STSP2_03160"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03160"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7242" checksum="ADC003C4F64A6943" modified="2017-06-07" version="1">MPDNEHQPDCPHHGEINAEIRNLKASDARQWDVLERVQNRLPVWATTWIGVLMAIAGALGTALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR5</accession>
    <name>A0A1U9NQR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ORF">STSP2_03477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03477"/>
    <dbReference type="EnsemblBacteria" id="AQT70271">
        <property type="protein sequence ID" value="AQT70271"/>
        <property type="gene ID" value="STSP2_03477"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03477"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34153" checksum="7842794EB1D36D8C" modified="2017-06-07" version="1">MPLVGTKKMFEMAYKNGYAVGAFNVNNMEITQGIVEAVAEEKAPLILQISRGARSYASMSYLKAIIDTAVAENPDIPIAMHLDHGDTVETCKQCVDDGFTSVMIDASHSPFAENIEITKKVVEYAHAHGVSVEAELGQLGGIEEDVVGVAADDVSKHLTDPDEVVEFVEKTGCDSLAIAIGTSHGAYKFKSEPKLAFEVLEQVHEKLPGFPLVMHGSSSVPQEFKDLINKYGGNMPDAVGVPEDAISKAVKLAICKVNIDTDLRMALTAKIREVFSTKPEEFDPRKYLGPGRAAIKDMVKRKLHVLGCAGKAAECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW2</accession>
    <name>A0A1U9NQW2_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Acetate operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iclR</name>
        <name evidence="5" type="ORF">STSP2_03519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00346">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT70313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="33739" checksum="5E44D9C0A5BAF8E2" modified="2017-06-07" version="1">MSAAIYAVDMGGWDVILLVKLGLLYKTGCVWWFFESIFMNGNGESSKYHVPNLERALEILELLSEHGEGLSLTSVVEKLGYPKNSVFRITKTLLDRGYLRRADDTKVFTLTHKMLTLGYGAVSEYSLVEKSLDIMRELRDEVRETVLIGILSGTYGVVLEQVVGSHLFKFMVNPGRRFPLHASAPGKAMWAFLPAREREMLLERVELKRYNDNTITDKGAMHEELDRVREAGYAIDRAEEVEGVRCVGAAVLDQHGYPVASIWSTGPSERMEKAGLEEAGRKTVEYARQISRRLGYGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR04</accession>
    <name>A0A1U9NR04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT70343">
        <property type="protein sequence ID" value="AQT70343"/>
        <property type="gene ID" value="STSP2_03549"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03549"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF362" evidence="2">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="363" mass="41090" checksum="B2D2C502A55F3799" modified="2017-06-07" version="1">MSKVAVIKTTPDTILDDVKRLMDMADVSSALDSSATTILKNNISWHLMYPSANTTPWQLEGTIQGLQKAGFDDLVCVENETVVTSAKKGEMYNKQRPVCEHYDVPIKYNFKPADMKWTTYQPKADMLVLDDIFPEGIRIPDYFHGKNVVHLPTVKCHIYTNMTGAMKNAFGGLLSNRRHYCHSKIHETLVDLLAIQKEIHPGIFTVMDGTTAGNGPGPRTMIPLRKDVLLASDDCVAIDAVSASLMGFEPMDHKFIRLAHERGLGTGRLDEIEIIGDFDVKNTDWQFSTGDNAASSVGKLFWFGPMKWLQRLMFHTPIVYMFIFASAVYHDKIWYPKEGKKVVKDWLENSEWGKMFQDYEPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC8</accession>
    <name>A0A1U9NRC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70086">
        <property type="protein sequence ID" value="AQT70086"/>
        <property type="gene ID" value="STSP2_03288"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03288"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="39187" checksum="A9615AFD1EA6C5EE" modified="2017-06-07" version="1">MKIFEKNHRQYRLAGSLNDFQMQMQMHLIDWKWKHITREPGLYGKREYDAILPRSLHGTYATVYPPVLDRLKTHARRFPFREHQYFNHMASSQAANVNLFLPVLISGSADQVLAKIKPDFARLATDKLDNGWQIEYWNKYLGDKRPSSGTDSDMAIAYYDHDGRLCLWLIEHKLTEAEFTTCGGAKSGGRQACHDCTGSLSDILADKNVCYYHSKRQFNYWKLTEANRDFFAGADSQAGCPFKGGMNQLWRNQLMGLAAEADPACEFERAFFSVVRHPGNRMLDATMDAYCQLTANSEKFRTFTSADVIAAATQTADPTLQDWARWYCDLYNLPLPGEEVGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRH6</accession>
    <name>A0A1U9NRH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03524"/>
    <dbReference type="EnsemblBacteria" id="AQT70318">
        <property type="protein sequence ID" value="AQT70318"/>
        <property type="gene ID" value="STSP2_03524"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03524"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="29531" checksum="55D3EE1E32AB043E" modified="2017-06-07" version="1">MNHKKAFTLIELLVVISIIALLLAIMMPALSMVKEKARAVVGMSRVKQWGLCYQLFTNDHDGSFPEFTPETTNTTFMYDLKDYYSDIDEMRFCPSAKKISQSNPTGVQQGSFFGSTLQAWKVNAGEANWLEDDDIGAGSYGENSYIRKRAGSSKAWGRANMPRANTVPVLMDARWNNAWPDNNQPLRTSATTEEEFYNYNNWSTISCFVMKRHGDGINMTMADGSAIKADAEELWQFRWNRDFEREENKDLSFMKWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG92</accession>
    <name>A0A1U9NG92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66943">
        <property type="protein sequence ID" value="AQT66943"/>
        <property type="gene ID" value="STSP2_00081"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00081"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="521" mass="59471" checksum="99FE27E6B468E061" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGC4</accession>
    <name>A0A1U9NGC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66865">
        <property type="protein sequence ID" value="AQT66865"/>
        <property type="gene ID" value="STSP2_00003"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00003"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="19267" checksum="53F33396BAFFA8D3" modified="2017-06-07" version="1">MPAITRFFRFILFTVFFITGASAVSISILVGEIDGYYESRQQLAEIEAQNAELTALLKDYDMRIYQARTNPDTIEKLQRVTLGIEPKAEDTIFPQASPSQLKSVEQVLETAETPTDEAPVRPQWVVRCSEPRFRYALFFAGFGLILVNFIFFGRPGPYADGEIRTVASQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGF7</accession>
    <name>A0A1U9NGF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fliG</name>
        <name evidence="13" type="ORF">STSP2_00033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00033"/>
    <dbReference type="EnsemblBacteria" id="AQT66895">
        <property type="protein sequence ID" value="AQT66895"/>
        <property type="gene ID" value="STSP2_00033"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00033"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="223"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="37319" checksum="9C19D5B40FE436BF" modified="2017-06-07" version="1">MANVNGVRKIAMLLLGLDAVTATELMKGLNPEEVQEIAMELAQLDASDQRDPKEEARIAREFHGVLQKKVAQRFNVKKFLNEALVNILGSGKAEEVRNQVMAVTQRKDPFINIRSATTDELVLALEGQHPQTTAAVLGELAPNKCQEVLSHLDEQTRRQTVRRMATLDQMTMDMKHRIAGMVNERLNKFKGEVLPEGREQTLRRLAVVLSGLDHKLRDELVGEINKEDEESCTMVKNLMVTWEDIPSIADRSLQECLRNVDVGKMAVALFEADEDIAQKIRANMSGRAVSMLDEEISLMQEPMEQEVIEARDEVVQPLREANEEGTLRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGI4</accession>
    <name>A0A1U9NGI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-4-deoxychorismate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.99.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sgcG_1</name>
        <name evidence="2" type="ORF">STSP2_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.24" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00005"/>
    <dbReference type="EnsemblBacteria" id="AQT66867">
        <property type="protein sequence ID" value="AQT66867"/>
        <property type="gene ID" value="STSP2_00005"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00005"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22782" checksum="5EFD7286DEE853EA" modified="2017-06-07" version="1">MYKQEPPKQQVLGISGSPRKNGNSDVLLEHVQKGVEALRIQCEKIHLRTMDFQSCIGCERCRKDKSCTGLKDDMTKVYPKVVSSQGLVLLSPAHTYNVSALMKAFIDRMYTFYNFGNDRPRSWSSQLAGQNRKAVLVGVAEQTDPKDMGFTIESMRVALQSLGYEVIDELAVYGIFDRGKVKNDVEVLEKATTLGKTLARSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ1</accession>
    <name>A0A1U9NGJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autotransporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00006"/>
    <dbReference type="EnsemblBacteria" id="AQT66868">
        <property type="protein sequence ID" value="AQT66868"/>
        <property type="gene ID" value="STSP2_00006"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00006"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911328" description="Autotransporter domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Autotransporter" evidence="3">
        <location>
            <begin position="557"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="834" mass="89176" checksum="9A216CB4E6BA5DF5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL3</accession>
    <name>A0A1U9NGL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67069">
        <property type="protein sequence ID" value="AQT67069"/>
        <property type="gene ID" value="STSP2_00209"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00209"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341559" evidence="1">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="30100" checksum="0E10CD86A1B9F9D8" modified="2017-06-07" version="1" precursor="true">MKKLAMCLVVLAMAVPTFAADVDFAFTDNGDGTGTLSWTINAPDTEIVGMGLNVDATTGTVDAVAVDSFFDVFIDAAYSDPTLYDGATAPGQLGTPVALQGSAGTTTLPNASFAISVGHLEGTTDGAGIVLTSGAGAEGQLDVNATRGGVVDQNGDALTTNLPIAFSIAQPGGFPVDHPDYDEWVAVGSPESWVTDYQCEGDADGAREGSPFTGYYQVGVEDLNILIAGWKDTDYVDPATDPWIAADFDHAEEGSPFTGYYRVGVEDLNILISNWKDDTNLTGTCLDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ1</accession>
    <name>A0A1U9NGZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase YjjG</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjjG</name>
        <name evidence="1" type="ORF">STSP2_00176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67037">
        <property type="protein sequence ID" value="AQT67037"/>
        <property type="gene ID" value="STSP2_00176"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00176"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="255" mass="29023" checksum="FDE3E61A968454A5" modified="2017-06-07" version="1">MAQTQTKALVTGNIKAVLFDLGDTLINFGEFKRTETVVKAARSAYDYLKQTNQPVRSFYGYILRHIIGLRFQTTWSAMTGKDFDSLQSLKTYGKHKKFDLTPEQYEELHWAWYRTLKDYAKIEPDLGETLAAMKNAGLKLGIVSNTFVNGHALDRHLSEENLIDYFDIRLYSYQVSRRKPHIRIFNDAAARLELDPGQIIFVGDRVDKDVKGAMNAGMHPVLKSAYTNRGKKVPDGVPKIDKISELPDLITKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH82</accession>
    <name>A0A1U9NH82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuA_3</name>
        <name evidence="7" type="synonym">leuA</name>
        <name evidence="9" type="ORF">STSP2_00435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00435"/>
    <dbReference type="EnsemblBacteria" id="AQT67292">
        <property type="protein sequence ID" value="AQT67292"/>
        <property type="gene ID" value="STSP2_00435"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00435"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="514" mass="55355" checksum="94E6179D712A9C7A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH86</accession>
    <name>A0A1U9NH86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67291">
        <property type="protein sequence ID" value="AQT67291"/>
        <property type="gene ID" value="STSP2_00434"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00434"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31221" checksum="1C9C4375F76A0305" modified="2017-06-07" version="1">MGRSKGFTLIELLVVIAIIALLMSIMVPALSVVKEKATGAVCLGNQRGLIQSYILYCNDNQDRLANSNTWNWDTATKTTDAWVAAPLTETLQWRGNAGVDVTLKDRYRGIRAGTLYEYTKNVDLYHCPSDKRVKHGTEDEGGLAYQMFRSYGIQGGLNGEELRPQLSGYAVKKHSAIKQPSSTYVFVEENYDGSGSNYNGGSWQIWNPNQSEPSWWNAPAVFHNEGSSLSYADGSAEVFKWKDKRTVEFAIDRDRVSADQPGNEDLEMMIDGYAVPLPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH98</accession>
    <name>A0A1U9NH98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67303">
        <property type="protein sequence ID" value="AQT67303"/>
        <property type="gene ID" value="STSP2_00446"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00446"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="56538" checksum="E008A3F1AC3E2AFB" modified="2017-06-07" version="1">MNRREFIRLAGGSVAALGFAGCAATSTSRKSGKGSGSKQPNLVFVFPDQMRGQALGFLDEDPVITPNLDKFASESLVLPQAVSNYPVCSPYRGMLMTGKYPHSNGVLSNCNSNGSLYGYELNKDDRCWSDVLKDKGYSLGYIGKWHLDAPYVPYVHCANNSRKFAWNEWCSPERRHGFDYWYAYGTYDYHNRPLYWSTDAGRNEFHYVDQWGPEHEADKAISFIRNDDGKYRDPDKPFAMVVSMNPPHTPYHLVPEKYKKMYADKTDEQLVNRPNVPPADERWGKYYRKNVRNYFAQVTGVDDQFGRILKELKAQGLDENTIVVFTSDHGNCLGCHSHSTKNVHWEESMRVPFIVRWPGKIKPRHDDLLISSPDIYPTLLEMMGRKRDIPQDVEGTSRADVFLTGQGERPDAQLYIWIPYGQPAYGRRGVRTHRYTLELTKKKGEGITKTILHDNKADPYQLKNIADEKPEVVTQLTEKLNAILARNSDPWLQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ0</accession>
    <name>A0A1U9NHJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xcpT_1</name>
        <name evidence="1" type="ORF">STSP2_00418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67275">
        <property type="protein sequence ID" value="AQT67275"/>
        <property type="gene ID" value="STSP2_00418"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00418"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17920" checksum="8C42074ED26D92D0" modified="2017-06-07" version="1" precursor="true">MKKAFTLVELMIVVAILGILAAIALPQLQAHTTQAKEATAKDSLRTMRQQISLFKTQHDGVLPGYAGGSSLSAAFMQMQFTNCTKADGTPGNYQTPTGDYQYGPYVLELPENPFNNRSDIIYVAEATAFSAAVDDSSGWLYKKETGEFHINTTGSDSDGKSYVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK2</accession>
    <name>A0A1U9NHK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67238">
        <property type="protein sequence ID" value="AQT67238"/>
        <property type="gene ID" value="STSP2_00381"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00381"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="611" mass="70576" checksum="4EE0D72B04A1519D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT7</accession>
    <name>A0A1U9NHT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ATP:guanido phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00216"/>
    <dbReference type="EnsemblBacteria" id="AQT67076">
        <property type="protein sequence ID" value="AQT67076"/>
        <property type="gene ID" value="STSP2_00216"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00216"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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    <sequence length="351" mass="39328" checksum="7B1338EC079CB457" modified="2017-06-07" version="1">MNLADLSKHTSTWFNTPGPQSEIVISSRVRLARNLAGFQFLPCLDSDRKSEILNKLTAELKGIDLDCRTSYIDIASATDLERELLVERHLISRRHANGTGPRGLVLSEDESFAAMINEEDHLRMQVYKTGLQLQQCWQRIDGIDDQLEKHLDYAFSPKYGYLTACPTNLGTGIRVSVMLHLPALKMTRQLDKFFNAARDLDLAVRGLFGEGTEATGDFFQLSNQVTLGLSEQEIVDQFATAIVPQIVAYESAAREELLRSRPAVLDDKVQRALGVLRSARLISSQEALFLLSHLRLGVNLGKLPNLSITDVNELFMLTQPAHLQLNARKTLTPDDRDVMRANIIREKLTTA</sequence>
</entry>
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</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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</entry>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
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    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="27879" checksum="44AA0D7D945D432B" modified="2017-06-07" version="1">MAEAIRDLKEDHVITNKARLDCILNLIALFHVRHPLVRRNIAKTQANLAKMTMQLICASKERYEETLRRMQMDGIEIGDVSFEQMKDFLERDEYDIETARESHIEMELKAIGPVLEMLGARNWTLLIASDTASQFITSDLPVTVSWNDPENIPPFVRQRPGLGYAETEVFFPITRTLALLGTFEPVKEQISLDRNSIAVLNSKTLCNAWSQVYAGDNKFEFIDHTGRIITGNQLLDWLNIREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI30</accession>
    <name>A0A1U9NI30_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0316 protein STSP2_00731</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_00731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0316 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00731"/>
    <dbReference type="EnsemblBacteria" id="AQT67583">
        <property type="protein sequence ID" value="AQT67583"/>
        <property type="gene ID" value="STSP2_00731"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00731"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01515">
        <property type="entry name" value="UPF0316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5698" evidence="9">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21240" checksum="D13A782EBCDA54D2" modified="2017-06-07" version="1">MELPDTQLFNYLILPLLIAVARIFDVSIGTIRIISVSRGHKLVSAILGFFEILVWLVVINKVMTDATNVFAYIGYAGGFAAGSAIGIWMEEKLAVGNLIVRVITRSDPTALINKLRLKGYGVTKVIGHGQHGEVDLVFAVIKRSNLEEVVGIINRFNPKAFYSVEDVKVVRQGVFPQRQSHRALARPLRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI67</accession>
    <name>A0A1U9NI67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00349"/>
    <dbReference type="EnsemblBacteria" id="AQT67206">
        <property type="protein sequence ID" value="AQT67206"/>
        <property type="gene ID" value="STSP2_00349"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00349"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012007530" evidence="5">
        <location>
            <begin position="27"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="FSH1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36968" checksum="19D7B1C404117D92" modified="2017-06-07" version="1" precursor="true">MSYNYKFARFALITALAFWLAISASASSNSDYDPLDIPADHEPEIIDTAVHDRARSRDIPLRIYLPASDSAAPVLLFSHGLGGSCKNNAYLANHWTARGYAAVFVQHPGSDNSVWKSVEPRQRLAAMQKAANGRNWLLRVRDIPVVIDRLEEWNAQTEHPLQNKLDLTRIGMSGHSFGAQTTQAVSGQTTHPRFSFTEPRIKAAVMFSPNCPKNLTPEQAFSRVKIPWMLMTGTKDTSVIGNATVESRLSVFGALPPGSKYELVLHDAEHSAFGDRALPGDTEPRNPNHHRAIVALTTAFWDAHLKNDTSARNWLNGPGPRTVLEPKDRWQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE7</accession>
    <name>A0A1U9NIE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-flavin oxidoreductase</fullName>
            <ecNumber evidence="2">1.6.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frp</name>
        <name evidence="2" type="ORF">STSP2_00429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67286">
        <property type="protein sequence ID" value="AQT67286"/>
        <property type="gene ID" value="STSP2_00429"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00429"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20066" checksum="86CCD2EA7F32802F" modified="2017-06-07" version="1">MNLFEVIKKRHSYRGAFTDQTVPREDLQKIVDAGLKAPSGCNAQTVQFVIVDDPETLGKIGQMHEKNLAIQQAKAMIVCVVDRDPKPVFEDLSFEVEDCAAAVQNMLLAITDLGYASVWIDGWLRREQRAEKIGELLGIPEDKVVRIVLPIGVPVEEKSQPDKKPFEQRAWFNQYGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM8</accession>
    <name>A0A1U9NIM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor CzrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">czrA</name>
        <name evidence="2" type="ORF">STSP2_00932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00932"/>
    <dbReference type="EnsemblBacteria" id="AQT67783">
        <property type="protein sequence ID" value="AQT67783"/>
        <property type="gene ID" value="STSP2_00932"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00932"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12503" checksum="B2AAC0413B3A853D" modified="2017-06-07" version="1">MTKENQMQKQKLDLLPDDYLEMAADCLKVMAHPVRLRIVNILMQGEFAVHEIAELCDLAPHQTCEHLRLLKGHGFLDSDRRGRTVYYKIASPQLPGLLECIKKNCNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV3</accession>
    <name>A0A1U9NIV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine betaine transport system permease protein OpuAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">opuAB</name>
        <name evidence="6" type="ORF">STSP2_01011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01011"/>
    <dbReference type="EnsemblBacteria" id="AQT67859">
        <property type="protein sequence ID" value="AQT67859"/>
        <property type="gene ID" value="STSP2_01011"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01011"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30709" checksum="D8D2305F2DC54D35" modified="2017-06-07" version="1">MTDFQIPRFPLGDYIDNGLEWLNRAISQETSATADFVNSLVMSIVDFLTFFPPVVLMLLITALAFWIKRSVKFSIFTFLGLYLLYNFNLWEPTMQTLALVVISTLVAISLGMPLGVLAALSKHAKSAIWPVLDFMQTLPPFVYLIPAIPFFGLGYTSAMFSTVIFAMPPAIRMTTLGIEQVPSELSEAADSFGSTRMQKLIKLQLPLAAPSIRAGINQTILLSLSMVVIAAMIGAKGLGGRVWEAIQRLEPGKGFEAGIGIVIVAIILDRLVGHVKKKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ5</accession>
    <name>A0A1U9NIZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01055"/>
    <dbReference type="EnsemblBacteria" id="AQT67903">
        <property type="protein sequence ID" value="AQT67903"/>
        <property type="gene ID" value="STSP2_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01055"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48570" checksum="EA18BC002F3D8497" modified="2017-06-07" version="1">MRQIRRVLKDRVDFRDNRAIFRGSVGPRVQRYFQFFVNDINRRGYDLIELDFSRATKAYPNSMVPIIATVQRLIHLGVTVHCNLPSNANLRTLFLRANWAYFLDPERFRPSDVTHDRHLSTRLFRDSGEQQRVVNELIDILMRTLEVKRSFFSGLEWAINEITDNVLTHSQADVGGFIQLTTYKDTKRLAFCVADPGQGILNSLREAEPTLRGDADAIADAVRAGVTRNKDVGQGNGLSGTMKIAMIANGRFLVASGRAWIAWQGGQPDTLSMAPGQAYQGTYVDVQLPLGEGIDLAEALSFGSGAKATLPADIIEIKYLSDDARKLKIKMGEETSGFGSRHAGKQIRTKAKNLLRSEPSCLLEIDWDGIQMVSSSYADEFIGKLFVDLQPIRFMNRVRQVNIIPVVEQLINKAIMQRVGQVATEIEGQQGGNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ8</accession>
    <name>A0A1U9NIZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67486">
        <property type="protein sequence ID" value="AQT67486"/>
        <property type="gene ID" value="STSP2_00633"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00633"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11489" checksum="476A9D1152FC579A" modified="2017-06-07" version="1">MADRPVRSDGTDHVHRFKQTLGIVFCAIYAVVYSSFVAISIYDITLMDTVMPFGLNLAAFFGIGLIIFALSLAAIYSRACSYSESKAAGQRDINEKASTAKERVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ13</accession>
    <name>A0A1U9NJ13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="3">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mucD_2</name>
        <name evidence="3" type="ORF">STSP2_00862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.107" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67714">
        <property type="protein sequence ID" value="AQT67714"/>
        <property type="gene ID" value="STSP2_00862"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00862"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143327" evidence="1">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51327" checksum="1C1417ACA3FEB89B" modified="2017-06-07" version="1" precursor="true">MVKRILLVLVSGVILAGLSGCNKPATVNKVIEDEPERLLDFRKIVQQAKDEVFPTVVYIKCIREDHTQGKKMSQEVGGSGVIISVDGEVLTNWHVVDKALEVRCLLYDGRAMDAEVLGTDKDADLALLKLDKGEDEQVPFANVGDSSKLREGDFVMAMGAPLGLSRSVSIGIISCTDRYLPDDSQYSVWLQTDASISPGNSGGPLVNTDGEVVGINTLGVIFGGDMGFSIPSNTVKMLVPQLREHGEVKWSWLGLQLQALRDFEKDIYFDGDQGVIVAETDPESPARRAGLQPRDRIMSIAGRDVRCLTQEDLPAIRRTIGMLEKGEIVTLQYSRGGEIRTVELKPTDKGAVEGEELDCPRWDMTVKEINRFDKPDLYFYRNEGVFIYGVKYPGNARDAGLRENDIILKIDGEKVKTLDDVSRIRKELVDKVDEKSKVVVSVLRKGLLRQCVLDYSRDYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ22</accession>
    <name>A0A1U9NJ22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antilisterial bacteriocin subtilosin biosynthesis protein AlbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA_1</name>
        <name evidence="7" type="ORF">STSP2_00887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00887"/>
    <dbReference type="EnsemblBacteria" id="AQT67738">
        <property type="protein sequence ID" value="AQT67738"/>
        <property type="gene ID" value="STSP2_00887"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00887"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="39039" checksum="F3945806FFA3BD9F" modified="2017-06-07" version="1">MMPSNGKNKRTLRLLFWESTIKCNLTCSHCRRVEGDEQVGTDMTTGQAKSLIDQLAELGKSQDFMPILVFSGGEPLCRDDVFELAGYAGDQGLRTALATNGTMIDAETAARIEDAGFARVSISLDGATEQVHNKLRQEPGCFDAALNGMAELQKANVPFQVNMTMTRHNAHQLDDIFNLAKNMRAQAVHLFMMVPVGCGEQFNQADMLDADEYEQMMKRIAATERSGNIEVKVTCGPHYERVKRQTQHQSARSRHPSKGCLAGSGVIFIGHQGDVFPCGYLPVNCGSVLRQPLADIWHGSEDLARMRDANRLTGKCGICEFKRLCGGCRARAYAATGDYMSEEPFCAYVPKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ23</accession>
    <name>A0A1U9NJ23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67933">
        <property type="protein sequence ID" value="AQT67933"/>
        <property type="gene ID" value="STSP2_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="10165" checksum="31F01F3A6B0848B7" modified="2017-06-07" version="1">MRITRIEFEGQIGYFATAHRKRYTDHIEVELLTPDFPNGKQYQIAANSEEDIYAMAEQMQLSLEGYRGTNSDIHDYYRELIRLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU3</accession>
    <name>A0A1U9NJU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68179">
        <property type="protein sequence ID" value="AQT68179"/>
        <property type="gene ID" value="STSP2_01334"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01334"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="50904" checksum="1FFE3783E0D488DB" modified="2017-06-07" version="1">MTDTTKHFSADVTAAVSLDTDSMLRAVALRRTGSGFEVVGHHCTEKSKDPSILPEQIKGFVESCEKKGCKSAVGIDSSSVAFYGLDLPPVPDDKAEPIIKIQLESLLPVPISSVEMSPVLLPMGMHGRTAAAAVAGKSFLNQGSSLSDAVKAEKVYLDCQAIVKAWRQLCNPADEKALVLHLTTACAQVILTEKGRVLSAKTFDTVFTSDNPDGRPNPELLLHDIRSALDGSKFCDDAMPRMSLLCGDANSDESLIGYLRAAGLDIERAIPDPSKIESEELSATQICDYIVPIGVAMLSADGETPEPDLFGSLARSQEEVRSQKKSKSWVVAAVVLVLVTAAGLITARQLDEKALAMLGTNDSNELGEQRELREKIAEHRPEVLELLSLINERLPNGMMLDSFTFSRGKPVTLSSNAANWSQMRQFEDKLAEQPGVKNMTEQNPTQDEKTKKISFRLSFDYKNYTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW1</accession>
    <name>A0A1U9NJW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">selD</name>
        <name evidence="10" type="ORF">STSP2_01367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01367"/>
    <dbReference type="EnsemblBacteria" id="AQT68211">
        <property type="protein sequence ID" value="AQT68211"/>
        <property type="gene ID" value="STSP2_01367"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01367"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="9">
        <location>
            <begin position="215"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="8">
        <location>
            <begin position="461"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="535" mass="56343" checksum="08A858B3E7B1618F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY2</accession>
    <name>A0A1U9NJY2_9BACT</name>
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        <submittedName>
            <fullName evidence="2">DNA phosphorothioation system restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01388"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    </dbReference>
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        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="46"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="831" mass="95194" checksum="9ECF8250C650760F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK30</accession>
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        <submittedName>
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        <name evidence="4" type="ORF">STSP2_01439</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FeFe-hyd_GTPase_HydF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
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        <property type="entry name" value="HydF_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040644">
        <property type="entry name" value="HydF_tetramer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="HydF_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HydF_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03918">
        <property type="entry name" value="GTP_HydF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_dimer" evidence="2">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_tetramer" evidence="3">
        <location>
            <begin position="279"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="44903" checksum="93D7FDA4561CC632" modified="2017-06-07" version="1">MLKTPKALRLHIGIFGRRNVGKSSVLNSLLSQQVSIVSEVAGTTTDPVEKVMELQPVGPVVFVDTAGIDDIGALGKMRVDKTYKAIEKTDLALVVTDRWQEYEQKLCAMLKEQGVPVIVVTNKADLRNDGELEEHIRDLKVGPVVATSIVKDEGISRLRQQIIEISEDVRIEKDTLLGGLVNDGDTVVLVVPIDIEAPKGRLILAQVQTLREVLDANCCAMVVKENMLEQTLTNLKQPPALVVTDSQAFAQVSKTVPADIPLTGFSVLFARYKGDLCSMVEGAMAIEELKGGDKVLISEACSHHPIGEDIGRIKIPRWLQSYVGDDLDIEVAAGRDFPEDLSDYKLVIHCGACVWNRRQVLSRIDIARKAQVPFTNYGLTIAYSLGVFERALQPFDDAMTIYKELAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK63</accession>
    <name>A0A1U9NK63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68124">
        <property type="protein sequence ID" value="AQT68124"/>
        <property type="gene ID" value="STSP2_01279"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01279"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14912" checksum="9DC22DBD084C11A9" modified="2017-06-07" version="1">MDVAVGVVFVAFDDAAGVVEGDGGAVEMVVAVVVEYAGWAGVVVYGVGVDIMDFVKSLFEAVSKLRFAFRRPFFRSAALCKIGKRIALTNFTRLAEPKKLLAGKPKAVSKQLLNYNGLVEGEQPFFAGGGDFAGFVRENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK94</accession>
    <name>A0A1U9NK94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type sodium pump subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ntpG</name>
        <name evidence="4" type="ORF">STSP2_01164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01164"/>
    <dbReference type="EnsemblBacteria" id="AQT68010">
        <property type="protein sequence ID" value="AQT68010"/>
        <property type="gene ID" value="STSP2_01164"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01164"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="10972" checksum="D0213C305939065D" modified="2017-06-07" version="1">MESKVAVLGGADFTMAFKALGIDTFPVEFNEDSVTKAANEVLKEKYGLVVVAENVVELAQPLLEKSAGHATPCVVVVPFLAEPSGVATAALSKQLKLATGIDILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD8</accession>
    <name>A0A1U9NKD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-reducing hydrogenase subunit HndA</fullName>
            <ecNumber evidence="7">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hndA_1</name>
        <name evidence="7" type="ORF">STSP2_01435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.1.3" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01435"/>
    <dbReference type="EnsemblBacteria" id="AQT68277">
        <property type="protein sequence ID" value="AQT68277"/>
        <property type="gene ID" value="STSP2_01435"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01435"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18467" checksum="4F0B7E07A5FCB17D" modified="2017-06-07" version="1">MIEAKDNKLQEVRDFIAGTKQKDYPESYLIAVLHKVQELYGYLPQDVMDFVAEEMQVPTAHIWGVATFYHYFNLEPIGKHVVSVCMGTACYVKGADKVLDALKGDLGVEAGQTTEDGLFTLQEARCLGACGIAPVIMIDDKIYGELTAKSVVDLLNQYRKAESAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH9</accession>
    <name>A0A1U9NKH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01591"/>
    <dbReference type="EnsemblBacteria" id="AQT68431">
        <property type="protein sequence ID" value="AQT68431"/>
        <property type="gene ID" value="STSP2_01591"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01591"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="180"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33722" checksum="330D676360F1FDEE" modified="2017-06-07" version="1">MIDNAFKLDVAKLMVAAAWADGQLQNSEINVLKSLMWELGELNAEDWAEIEIYMDSPVSDEERQALENRVYNKISSSEEKEFVEYMLSKLLTSDGIVGTEEKAFLQDTKALIDGASTGLTGKLSKLMRSVIGNNKNTTPDTARETDIEDFLRNKIFYSLKQNGIDTNLSEDQARKLSFAAGLLGLVANVDKDICTNERKAAVHILQNNWDLDPQTAQAIVDVASDETTQGLDKYRLTDGFYQNTTREQRQRFMVCLFKIAAASGQASHEEIEEIRDIAVGLKLSHQDFIAAKVTLTDKQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL2</accession>
    <name>A0A1U9NKL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68130">
        <property type="protein sequence ID" value="AQT68130"/>
        <property type="gene ID" value="STSP2_01285"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01285"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12681" checksum="A7BD99A8D4B611FE" modified="2017-06-07" version="1">MELTRTIAQYSTAILEMLGIMIIVALSLYSVLYTCIALLKGAEHHDAFRDCRQKLARGIVTGLELLIAADVIKTVALDLTFTSIGALAAIVLIRTFLSATLELEMTGNWPWQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL6</accession>
    <name>A0A1U9NKL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01635"/>
    <dbReference type="EnsemblBacteria" id="AQT68471">
        <property type="protein sequence ID" value="AQT68471"/>
        <property type="gene ID" value="STSP2_01635"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01635"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010697312" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="673" mass="72560" checksum="3CF7CC8DC84E0BB7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM6</accession>
    <name>A0A1U9NKM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PA14 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01645"/>
    <dbReference type="EnsemblBacteria" id="AQT68481">
        <property type="protein sequence ID" value="AQT68481"/>
        <property type="gene ID" value="STSP2_01645"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01645"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029031">
        <property type="entry name" value="Gingipain_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038490">
        <property type="entry name" value="Gingipain_propep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012600">
        <property type="entry name" value="Propeptide_C25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08126">
        <property type="entry name" value="Propeptide_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143323" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1552" mass="168472" checksum="870655DA46F5C80F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN9</accession>
    <name>A0A1U9NKN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01535"/>
    <dbReference type="EnsemblBacteria" id="AQT68375">
        <property type="protein sequence ID" value="AQT68375"/>
        <property type="gene ID" value="STSP2_01535"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01535"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070569">
        <property type="term" value="F:uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="PTHR11952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="52337" checksum="8D845AB905D48F46" modified="2017-06-07" version="1">MSDIKSYEQIKELLTQHGQQHLLAFYDELDEKQQQKLLSQLSELDFVQIDEWAEKYVKNDSPMEVPSEFEPAPSYPAEPEDDKQAATYKQAVEKGVKLLENGKVAGFTVAGGQGTRLGFSGPKGNYPISPVKQKTLFQLFAETVAAASAKFGAAIPWYIMTSPLNHAETVETFEQSSYFGLNPDNVFIFQQGTNINFSLDGKILLAEKDKLATSPDGHGGSLKALHVSGAIADMKKRGVEYISYWQVDNPLVRLFDPLFIGLHAKNNAGMSSKALIKAYPTEKVGNFCLVDGKVTVIEYSDLPEDDAHRQNPDGSLVFELGSIAIHIVSVDFVEKLNAHGFALPIHRAVKKIPHINEKGEKVKPEEPNGVKLETFVFDALPLADESIILETVREEEFAPVKNAEGTDSPAVTKQMMTERAAKWLEAAGIQIPRNSEGKPDCVIEMAPSFAIFPEDVEAKKAAVPDIKPGDEIYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP6</accession>
    <name>A0A1U9NKP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-K factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigK</name>
        <name evidence="4" type="ORF">STSP2_01643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01643"/>
    <dbReference type="EnsemblBacteria" id="AQT68479">
        <property type="protein sequence ID" value="AQT68479"/>
        <property type="gene ID" value="STSP2_01643"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01643"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21521" checksum="85EA64376D4C7A57" modified="2017-06-07" version="1">MSDLDSGKTKYSDKERSDLFFKLFMANQKRIYSYILMLVPNCNDADEIMQEASAVMWQKFDEFEQGTNFGAWAVSIARFEVLNYTRKRKNSHVLFTGDMLDLFAGRAETVSGESDERMKAVQKCLEKLSKKDRRLLQMHYEGGLTIKGIAQSLDRSVQGMYKVMNRIHNSLIKCVRWRLVSEDSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ8</accession>
    <name>A0A1U9NKQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68318">
        <property type="protein sequence ID" value="AQT68318"/>
        <property type="gene ID" value="STSP2_01477"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01477"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341545" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="109" mass="11713" checksum="B7031E30D6FC95B6" modified="2017-06-07" version="1" precursor="true">MLISLMKSKRFVVFGVAVLAAVVVFAANTSAAPEDQTDGFLDPFSLTVSSYSTDSDAQSFDPTVSSAMFEGFTDVSGSVDSTEATVVEISMPRPPIVPYRPRPRSPIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR4</accession>
    <name>A0A1U9NKR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">epsF_2</name>
        <name evidence="12" type="ORF">STSP2_01686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01686"/>
    <dbReference type="EnsemblBacteria" id="AQT68521">
        <property type="protein sequence ID" value="AQT68521"/>
        <property type="gene ID" value="STSP2_01686"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01686"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="75"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="413" mass="45431" checksum="FE9DEE4EC96F7F5C" modified="2017-06-07" version="1">MAKFKYEALDAKGKEVKAEIDALSSDEAISKLKNKGLFPTKVEAKGGSKKTQVKKTGRQKKRRSGKVKTKQICQFSRQLSTLQDAGLAILRSLRILEQQQKPGTLKRVVGYLAEDIEGGATLSEAMAKHPKCFSELFVNMVAAGEVGGVLDVILSRLADFLEKSERLKSKIKGAMVYPVVVMTAAIAIVLGLMIFVIPTFAEVLSDMGDGADLPWLTQKLLDLSDWLCNWWNAGMVVASPFVIIAFVKFIKQFRNGRYVVDQVKLHTPVIKKIVYKTAVARWTRTLGTLISAGVPILEAINIARDTSGNEVYARMLEKVHHSIRQGDSFANPLRASKTVDSIVVNMVDVGEETGDLDKMLEKVANNFDEEADVLVGSLMSLLEPIMIIFLGGMVGTIVLAMFLPMVKIIQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR7</accession>
    <name>A0A1U9NKR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01261"/>
    <dbReference type="EnsemblBacteria" id="AQT68106">
        <property type="protein sequence ID" value="AQT68106"/>
        <property type="gene ID" value="STSP2_01261"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01261"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11755">
        <property type="entry name" value="GH94N_ChBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037828">
        <property type="entry name" value="GH94N_ChBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="798" mass="90280" checksum="DCCA44B43A83ED40" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU9</accession>
    <name>A0A1U9NKU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tatC2</name>
        <name evidence="5" type="synonym">tatC</name>
        <name evidence="6" type="ORF">STSP2_01740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01740"/>
    <dbReference type="EnsemblBacteria" id="AQT68572">
        <property type="protein sequence ID" value="AQT68572"/>
        <property type="gene ID" value="STSP2_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01740"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29420" checksum="0192D7F6627A4165" modified="2017-06-07" version="1">MMQIEHEKLASMSLGDHLEELRIRLMLAIGGVFAGMIIGMILAGRLISFLVAQYRGIMEEAGKEPSMQFIEMADPIIVYLKISLFIGVVIAAPWIIYQLWAFVASGLYNHEKKFMKTVTPACTILFLTGAAFFFKFVGPMAIRFFVKLDYGSDFLSYNPTLRSYISFLLTLTIVFGLGFQLPIVIIFANKIGIVTVDMLKQGRKYVIMGLFIVAAVITPPDVFSQIALAVPMFFLYEASIIFCQIAAKKKAEKEESDSTDNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV1</accession>
    <name>A0A1U9NKV1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pta_1</name>
        <name evidence="6" type="ORF">STSP2_01704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01704"/>
    <dbReference type="EnsemblBacteria" id="AQT68539">
        <property type="protein sequence ID" value="AQT68539"/>
        <property type="gene ID" value="STSP2_01704"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01704"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35033" checksum="38DB08BFC90D832A" modified="2017-06-07" version="1">MADFLQSILDRAASLNKTVVLPEASDERTLQAAKTISEKKFVKPVLIGNVDKVTAKLKEMGADTEFITVVDPATSPKKEQYAELFHELRKHKGMTADKAAEIIQDEIYFATMMVKAGDADGLVAGAAHSSADTIRPALQIIKAREGVKTVSSMFFMVFPDATYLFSDCGLNQDPNAEQLADIAVATAQTGLQFGFDPKVAMLSYSTKGSGTGQGAEKVVEATKLANAAIKERFGDKVAIDGELQFDAAFVPSVAEKKAPDSPLNGEANVFIFPDLGAGNICYKLTQRMAGADAYGPVLQGLDKPVNDLSRGCTADDIVATAAITAIQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ9</accession>
    <name>A0A1U9NKZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68477">
        <property type="protein sequence ID" value="AQT68477"/>
        <property type="gene ID" value="STSP2_01641"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01641"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="53" mass="6163" checksum="D52C1EFC1ECF1520" modified="2017-06-07" version="1">MPVKRLKSSPKRLCFTYEMRFFIMHTLTVRAVNVDRMVYSANLRDLKASINGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL29</accession>
    <name>A0A1U9NL29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Virulence factor Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01787"/>
    <dbReference type="EnsemblBacteria" id="AQT68619">
        <property type="protein sequence ID" value="AQT68619"/>
        <property type="gene ID" value="STSP2_01787"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01787"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="36710" checksum="686A1B81A965B7A7" modified="2017-06-07" version="1">MADYNTQQRHRNTIVGGFVIIAFCALIWMIAMFGELPVMATEWTSYEITAEFPQSAGIHKTTPVRYVGYPVGKVTQVAEPQFNLVETPQGKISQPKVTVRIAIDQDYSMIPANVKVRLTTRSMGSSYIELLPNDEEPVPMEDGSVKFLTQGMRLEGYVGAANEFIPEHIQDKLEVLVVKVTDLTTNLNDVLGDVENKKNIQQTLAHIADVTRQAGDAMEKFTSMTEQAGTTLGDISDLTDRADDTLVSIEDLSHSTKNAVLDTVSRLDDALVSVNNILHKIDQGEGTTAKMLNDGKLYENLLDSTKELENALQQFKNFAEEARRDGLKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL77</accession>
    <name>A0A1U9NL77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trpF</name>
        <name evidence="6" type="ORF">STSP2_01753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01753"/>
    <dbReference type="EnsemblBacteria" id="AQT68585">
        <property type="protein sequence ID" value="AQT68585"/>
        <property type="gene ID" value="STSP2_01753"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01753"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="23353" checksum="02CF46689E2290A2" modified="2017-06-07" version="1">MALVKIKVCGITNVEDAMAAIDMGADLLGFNFYRESPRYLDAADALDIINKIPTFVDTAGVFVNPSMEELREIVELGFLNWVQLHGDEDPDFCDSLRYMNCRTIKAIRVKSQEDIKRAKDYYTDAVLFDAYHPNYYGGTGETFDWRLIDDLNRRVFLAGGLDPDNAEDAVSVGVYGIDVCSGIESSPGKKDLNEMKRFFDNIRHLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA6</accession>
    <name>A0A1U9NLA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smpB</name>
        <name evidence="5" type="ORF">STSP2_01510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01510"/>
    <dbReference type="EnsemblBacteria" id="AQT68350">
        <property type="protein sequence ID" value="AQT68350"/>
        <property type="gene ID" value="STSP2_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01510"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="20036" checksum="7CA4117F393E5284" modified="2017-06-07" version="1">MQNARLVFIIGRMSKKSKKQQKSGPVNVKNKKAYRDYELIEKVEAGIELVGTEVKSLRQGQADLDGSYARVENDQCWLVGAQIAQYAEASYNNHDPLRQRRLLLHKRQILKIKTKLQQRGFTLVPLRFYFNDRGYAKVELALAKGKRKYDKRDKLQKEQQKRDIARSLKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE9</accession>
    <name>A0A1U9NLE9_9BACT</name>
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        </submittedName>
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        <name evidence="5" type="primary">mngB_4</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH38_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="20"/>
            <end position="1122"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68763.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125739" checksum="4CA5FFAE9F546D18" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK0</accession>
    <name>A0A1U9NLK0_9BACT</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <property type="gene ID" value="STSP2_01987"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8350" checksum="2B9E21264454A8A1" modified="2017-06-07" version="1">MLKKRSYKTVMTGKWHLGHHREFLTLQHDFDEYLGLPYSNDMWSVDFDSNSSKGRKNFKGDNAQCMGTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM0</accession>
    <name>A0A1U9NLM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00624</name>
        <name evidence="5" type="ORF">STSP2_01869</name>
        <name evidence="6" type="ORF">STSP2_02335</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67477">
        <property type="protein sequence ID" value="AQT67477"/>
        <property type="gene ID" value="STSP2_00624"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68697">
        <property type="protein sequence ID" value="AQT68697"/>
        <property type="gene ID" value="STSP2_01869"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69148">
        <property type="protein sequence ID" value="AQT69148"/>
        <property type="gene ID" value="STSP2_02335"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00624"/>
    <dbReference type="KEGG" id="alus:STSP2_01869"/>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="155"/>
            <end position="395"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="403" mass="46763" checksum="41C243C23B9223BC" modified="2017-06-07" version="1">MTGQHLIKKLGQWEGYRVGTVGPAKKGPEFWVELIPEYGHGICDGCGQECSSVHETVQRWIRDLPVFDKTTHLLVHRRRLLCPRCGPKLERISWLDRYSRHTTRLVESVARLCDVMSIKHVAEYFSLSWSTVKDIHKRHLKKKLGPVDLSNVELLAMDEFAIQKGHRYATVIIDPTCKKVLWVGRGRSRASIRPFFEMLGDRCKDIKAVAMDMNASFEQEVQLHCPQAEIVYDLFHVVAKYGREVIDRVRVDQANRLRDDKPARRVIKGSRWLLLRNRENIEKPEDLVRLDELLAANESLMTTYVMKDDLKLLWNLSDRKAAESCWGQWLDRAMQSGIEPLMKFAKRLSKYAAGIIAHSRWPLHTSLLEGINNKIKTIKRQAYGYRDDEYFFLRIRAAFPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT9</accession>
    <name>A0A1U9NLT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02078"/>
    <dbReference type="EnsemblBacteria" id="AQT68901">
        <property type="protein sequence ID" value="AQT68901"/>
        <property type="gene ID" value="STSP2_02078"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02078"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40472" checksum="608AA72AAB47453B" modified="2017-06-07" version="1">MVSLFRKKAFPIGLDIGSSSIKMIQIGGCGSGERIIAAEQVDLTPDIRNDNELKRDFAVCAIKEMLSRGGFQGKDVISCLPNGSVKNKSMRVTIGEDDETDDINRQLAARLGLDADKDEIRHLLAGRVMQGDDVKSEVICFGVGKETIDSHIDLLEESGLVPVGLDAVPCSILRSVRRSLRRQADREKNRFYIDLGSKYTTVIAGGENGLSFIKQIPMGGNLLNEAVSRCLEVDINRSIELRRKLQCGNDSINSSTRRALIDAMRDVNEELAREISMCMRYYAVTFRGHSPDEALLSGGEAYEQTLVNALKRRLGVDVEVAHPLRGFDIEKTDLTMSGDGSMCEWAVAIGAGIKGRDSLAIGSQKYARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV1</accession>
    <name>A0A1U9NLV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane lipoprotein-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68560">
        <property type="protein sequence ID" value="AQT68560"/>
        <property type="gene ID" value="STSP2_01728"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01728"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="32999" checksum="CBD94BCED1BFFB73" modified="2017-06-07" version="1" precursor="true">MNRHITTLAVLFTCIFAAFSPAETKEKGGKNEQSAIKNEQKQDKTSQKIPTTVDGIIEKLRDRTSKLDTYKANINYLFIQDPELLDSRRLQKGKLYYKKTKDGSGLKIEFSTVKQDDAPEEKRKEELFFDGVWLTRIDYRNETVNSYQQVPEDKPVDAFDFVSQNFPMVGFSHAKDLRKQFEIELIDSDTKPTDSDDKKMEDTIHLRMKVKEGSVYEEDYKLIDFWVDKKLFLPKRIRSVSVEDDIYDITLLDAKVNKKIENSIFSVEHPSSFSKNREPLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV2</accession>
    <name>A0A1U9NLV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01630"/>
    <dbReference type="EnsemblBacteria" id="AQT68466">
        <property type="protein sequence ID" value="AQT68466"/>
        <property type="gene ID" value="STSP2_01630"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01630"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="588" mass="64664" checksum="76A0FEFE7356DD57" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ3</accession>
    <name>A0A1U9NLZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cystathionine beta-lyase PatB</fullName>
            <ecNumber evidence="2">4.4.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">patB</name>
        <name evidence="2" type="ORF">STSP2_02106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02106"/>
    <dbReference type="EnsemblBacteria" id="AQT68929">
        <property type="protein sequence ID" value="AQT68929"/>
        <property type="gene ID" value="STSP2_02106"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02106"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004121">
        <property type="term" value="F:cystathionine beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="42406" checksum="EA4AB484BFF4C3CF" modified="2017-06-07" version="1">MDSVFDKVVDRSCSSSLKWDRYKGRDIIPMWVADMDFEAPPAVIQALHTRVDHGVFGYTLPPAELTNTILEYLADEFSWQIEPGWIVWLPGLVTGINVASRSTGESGNEIITFTPAYPPFLDAPGLSDRKNVTVPLVIQDGRYSFDEQNLKQAITPRTSLLNLCSPHNPTGRVWDKNELEKIAEICLSNDVVICSDEIHNGLVLDDVKHIPTATLSEEVAQKTITLMAPSKTFNIAGLGCSFAIIPNESLRRRFLHVMEGIVPHVNALAYTSALAAYRDSGQWRKDLLEYLRSNRDLVLDFVNERIPELSAENIEATYLAWIDARSLGPDDPARFFAEHGVGLLDGKEFGAEGFVRLNFGCPRRTLMQGLTRMQTAVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ8</accession>
    <name>A0A1U9NLZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kpsU</name>
        <name evidence="2" type="synonym">kdsB</name>
        <name evidence="3" type="ORF">STSP2_01778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01778"/>
    <dbReference type="EnsemblBacteria" id="AQT68610">
        <property type="protein sequence ID" value="AQT68610"/>
        <property type="gene ID" value="STSP2_01778"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01778"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27009" checksum="B52367CDCF24BBC3" modified="2017-06-07" version="1">MKTIIVIPARYDSTRFPGKVLADDTGKFLVQHTYERALCAENADEVLIATDSEKVLRACESFGAKAVMTSGTHQSGTDRIAEAVTQSDAELVVNLQADEPEIDPAYIDKLIDLLKSDEGSQMATLVSGFGNPDQVKDPNVVKVVTQVNGRAIYFSRSPIPFSRESNGVGDLDNYLRHLGVYAYRREFLTAFTSLPQGELEKTEKLEQLRALENGYSIITGKVEHTWDGIDTAEQYAQFVKRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM06</accession>
    <name>A0A1U9NM06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neu5Ac permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">siaT</name>
        <name evidence="5" type="ORF">STSP2_01788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01788"/>
    <dbReference type="EnsemblBacteria" id="AQT68620">
        <property type="protein sequence ID" value="AQT68620"/>
        <property type="gene ID" value="STSP2_01788"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01788"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="45324" checksum="206E684475A76BBF" modified="2017-06-07" version="1">MDLPVFVLVTSFVILMAMNVPIAFCMGISTVLSILAIGDIPTFVAVSHKIATGIDSFSLLAIPFFILSGLFMGHGGIARRLIDFANVLVGRFRGGLAFVNVLTCMLFGAISGSAAAAVSSVGGFMIPLMNKMGYDKDFNGSVTVTAATTGLLIPPSNVMIVYSLATGGAVSIAAIFIAGILPGILVGLALITVSAVISIKHNYGKGETFALREGIIRFLKAIPALLLIIIVLGGILGGYFTATEASAVAVLYAFILSVVFYREVKLTDIPKILLQAGVTTSVVFLLIGTSMAMSWVLAAERVPQDISAGLLGLSSNKFVILLMINLILLAVGTFMDMTPAILIFTPIFLPIAKGLGIEPVHFGIIMILNLCIGLCTPPVGTCLFLGCGIAETTVTRMIRKIWPFFLAMIAVLLICTFVPAVSTALPKLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM38</accession>
    <name>A0A1U9NM38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68788">
        <property type="protein sequence ID" value="AQT68788"/>
        <property type="gene ID" value="STSP2_01961"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01961"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16928" checksum="6D1E4510EF484E8A" modified="2017-06-07" version="1">MAFSELRLVKNCVEYMPQAEIDRIPPRTRGIYVLYKHDPQSKMYDVVYIGMAGGENKASIRGRLRRHRSKKGDEWTHCSVFEVWDNIREEEVRELEGILRHIFRKDQQANKLNQQKAFMKLKHVRAHTKQSDWLLSESNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM69</accession>
    <name>A0A1U9NM69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69042">
        <property type="protein sequence ID" value="AQT69042"/>
        <property type="gene ID" value="STSP2_02225"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02225"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="21032" checksum="47B6C2899C0261C2" modified="2017-06-07" version="1">MSSQSNDYEIALESWLIENRLKYVAVDQQKRNHFARNSVKSFDFLLYNNRAGLCPDAADMIVAEVKGRLYKGTNFASLSGLQNWVTQDDVIGLEDWQSVLQESSARQKVEAVFVFAYRFEKIDVETDGRATYDFCDNRYAFLAVKLDDYRKLMKVRSPKWKTFSVPAADFRQIAKPLGQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA8</accession>
    <name>A0A1U9NMA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">STSP2_02226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02226"/>
    <dbReference type="EnsemblBacteria" id="AQT69043">
        <property type="protein sequence ID" value="AQT69043"/>
        <property type="gene ID" value="STSP2_02226"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02226"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="48"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35672" checksum="D9F4B07AAEEBF91B" modified="2017-06-07" version="1">MNKIITDLAGKVLTGELLDQNECRMLLDEAESDYDDLLYWANRIRQANFGNKVKMCSIVPARLGGCDQDCAFCAQSVRYNTNIDKRAKLLSDEEILAAARNARDNGVRSFGIVYSGRAITDEELDRVIELAKIIKNDYGLQLCGSLGTISAEQAKLLADAGFSRYNHNVETSRSHFPNIVTTHKFDDRVKTIKNAISAGLGVCGGGLFGLGETQADRIEMAIELRDLGVDMVPMNFLHPIEGTPMGDNEPMQPREILTTVALYRFILPKASLKVAGGRKLNLRTLQSWIFQAGATSIITGDYLTTAGSSVSEDVQMLKDLGLEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB7</accession>
    <name>A0A1U9NMB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplT</name>
        <name evidence="8" type="ORF">STSP2_02238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02238"/>
    <dbReference type="EnsemblBacteria" id="AQT69053">
        <property type="protein sequence ID" value="AQT69053"/>
        <property type="gene ID" value="STSP2_02238"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02238"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13364" checksum="5CF194A0FA53DA30" modified="2017-06-07" version="1">MPRVRKGAARRKAHKRVQKGVKGHRSAAGRLHRLAKEANVRKEVNARVGRKLKKRDYRGLWIIRINAACRERGIRYSQFINGLKKANIEVNRKMLSEIAIADPKGFDTIVEQVKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR7</accession>
    <name>A0A1U9NMR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CzcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">czcB</name>
        <name evidence="4" type="ORF">STSP2_02312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69125">
        <property type="protein sequence ID" value="AQT69125"/>
        <property type="gene ID" value="STSP2_02312"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02312"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="133"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="50403" checksum="0A2C349CC67168A4" modified="2017-06-07" version="1">MKTRNIITVITVLILVAGIGYIAATNFKTMGGEMPGHTDSVSEHQDHAEADHSTHEGHGDHEGHDEHTENIEQEPDDHADHDEHDEGHADHDDHAEESEDSHADHDEAQVVELTDEQIEEIGLVTDVAGPGTIRKTIALPGEIRVNQDRMAHIVPRVPGAAIKVNKSLGDSVKEGEVIAVIDSSELADAKAAFLAAVERLEMARLTFEREEKLWKDKVSAEQDYLAAKQALSEARIERRAARQKLQAIGFGDQYIQNLPEEPDQQLTRYEIKAPFDGTIIQKHIVLGELLDTSSPVYIVADLSSVWVDLQVYPKDLASVEPGSRVTVSAPAAISNQTGTIDYVGPILGADSRTALARVVLSNESGKLRPGLYVTGTVTVKDQEVPIIVPKNAVQRLHEQKCVFIKDEHGFEPAFVKTGLESRTHVQIVSGLSPGQTYVTQGAFTLKSKIITSTLDSHAGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW8</accession>
    <name>A0A1U9NMW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69084">
        <property type="protein sequence ID" value="AQT69084"/>
        <property type="gene ID" value="STSP2_02270"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02270"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="45" mass="5065" checksum="4D25F8E376A1C3DB" modified="2017-06-07" version="1">MIEYFWLILSVGCIGWYLVILGYVAVRGGADIKQMLKSLSGKENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX3</accession>
    <name>A0A1U9NMX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69302">
        <property type="protein sequence ID" value="AQT69302"/>
        <property type="gene ID" value="STSP2_02491"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02491"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10099" checksum="644F7A7CDA47408A" modified="2017-06-07" version="1">MKVSAEKLKLILAASIFANLIMLAFLAYVTSSLAPMPNQTMHDQARADAHFIQQVDTAIARNDIAKLAELRTQLQQIAHPKTINGQGTWPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ6</accession>
    <name>A0A1U9NMZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin-synthase adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moeB_1</name>
        <name evidence="3" type="ORF">STSP2_02472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.80" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02472"/>
    <dbReference type="EnsemblBacteria" id="AQT69283">
        <property type="protein sequence ID" value="AQT69283"/>
        <property type="gene ID" value="STSP2_02472"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02472"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012729">
        <property type="entry name" value="ThiF_fam2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032726">
        <property type="entry name" value="ThiS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14453">
        <property type="entry name" value="ThiS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02354">
        <property type="entry name" value="thiF_fam2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiS-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="104"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32028" checksum="9C92373DEA849DAB" modified="2017-06-07" version="1">MGYRWRVRPETVRLVEYVLFVDGWVISVHIYVNEKQFEVVDRISVQQVREQFKLDADVVIVNGFAVSGDVELREGDRVVLIKRGELPGRRELEGLMVARHTPGVHERVKAATVGIAGLGGLGSAIAIALARVGVGRLVVADFDVVEPSNLNRQQYFVDQIGMTKTEATRENIERINPYVKVISHQGRIEAGNVAEVFGGVDVMCEAFDGADQKAMLCESFTGAFSDTPLVMAAGVAGFERSNTVVTRKLGKNLYLVGDMETGAGLGVGLMSPRVGIAAHHQANAVLRLLLGEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN03</accession>
    <name>A0A1U9NN03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02295"/>
    <dbReference type="EnsemblBacteria" id="AQT69108">
        <property type="protein sequence ID" value="AQT69108"/>
        <property type="gene ID" value="STSP2_02295"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02295"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013092494" evidence="1">
        <location>
            <begin position="21"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="868" mass="93255" checksum="F48931EB938D81CC" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN49</accession>
    <name>A0A1U9NN49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Galactose mutarotase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Type-1 mutarotase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mro_2</name>
        <name evidence="6" type="ORF">STSP2_02518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02518"/>
    <dbReference type="EnsemblBacteria" id="AQT69329">
        <property type="protein sequence ID" value="AQT69329"/>
        <property type="gene ID" value="STSP2_02518"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02518"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="5">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="zf-TFIIB" evidence="5">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="492" mass="54429" checksum="0B41BB84E4F6D2B1" modified="2017-06-07" version="1">MDCPVCKEAMITLELDEVEIDYCGECSGIWLDAGELEMLLDDGGKAKKLLDSFSQAKKVKEKHRRCPICLKKMLKIFVGDEAEGKGRLLIDKCPAGHGLWFDRGELRDIISLVSFDQEHRVVKLLRDMFCNECESDASTDEEGNTMIVNKQIYGKTRDGEDIYLFRMENENGVAAQVTNYGAILVSVETPDRDGKGADVTLGFDTLEGWMEQNGPYFGATVGRVANRIAKGKFTLEGQEYELAVNNGPNHLHGGIKGFDKVVWDAEEVTKENEASVRFEYTSADGEEGYPGNLTVSVTYTLNNENELVVAYEGRTDKATPVNMTNHTYWNLAGHDAGDICGHQLVMHANMYTELDEDNVPTGKVKPVNGTALDFTSPHKIGERIDAIGGYDHNVVLNKAPGEMGLVAEVYEPGSGRTMRVYTTQPGMQLYTAEFLDGSVKGKGGAAYGPRSAFCLETQHYPDSVNHEEFPSTVIRPGEVYKEKTVFKFGTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN55</accession>
    <name>A0A1U9NN55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translocation protein TolB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69174">
        <property type="protein sequence ID" value="AQT69174"/>
        <property type="gene ID" value="STSP2_02361"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02361"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040698">
        <property type="entry name" value="HZS_alpha_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18582">
        <property type="entry name" value="HZS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69174.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    <sequence length="968" mass="109539" checksum="E1538BCD284882A7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
    <sequence length="307" mass="35979" checksum="DBB2FB78828CCD31" modified="2017-06-07" version="1">MTNNMKKTIQRKPQFRTQVVTFEDSQHKSIYKCPASELAKEFIKTIPEKEQANAEYVKDVFEVLNGTLHGSSIEYDYLPLPSVEDKVIECLQKRRIDQATKWLDDFIARINSLPVTKTLPIEFLTIIARSETCDFESARCLCPGLIDLIPRNVLCKNDNWIIIDNEWSFRFAVPVSFVIFRSIYSIAVLYQNLIRLNASRNEPAVVFFKSGHKTYYIPLKWSRFLTQLDIRTSTMLRWETAFQKYVTGISSQLDKRVPDRPQCRTAFFCTNLFVRSKLTHLSLLRRAEKRAARFIDTFCNHDRWLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF5</accession>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ST-NAGAB-D1</strain>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AQT69385.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10994" checksum="7898566BBBF740A1" modified="2017-06-07" version="1">MAEASGKNNDHNGAAEEKARAYVETLSPEHKMLLVLKAQLYGGSWQPMLDDLNNRLEGKPYIFKLANRIKGDVERIEELMKFEKENDIDLSKFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN6</accession>
    <name>A0A1U9NNN6_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Colicin V production protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02527</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69338.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
    <sequence length="358" mass="38927" checksum="EE19D55408036F84" modified="2017-06-07" version="1">MFAYIAIPLITILCVAQFYLKNSLLKSVATLLSALIALITAFGFYEPLAETLISRGYGVEWAQPGCFILLFAITFAVARILSDFMIGANIEFGRVPRVVSAIVCGALVGIIVSGTLIVALAMTPLHPKIPYDRFGESLNVSQPKSTLLNADVVVTKLFNVTSGGSFSAKRSFGVYHADFVDQLHLSRRKTGEDVMTIAARDAITIEKDGVKRIDSGTGPARTHIRVGIKGSSVKDGGARQENQYVAFTPAQMRLVCVSKTDPSDASILYPKAYKPAKQNWPASRDEKIDLDEVIKFAPNDFKSQQKIAWIDLAYQVPSNCRPLAVEFKKNTIEKVPSASEGDDEPMPADTSGEDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN9</accession>
    <name>A0A1U9NNN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="primary">pstS1</name>
        <name evidence="6" type="ORF">STSP2_02714</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT69523"/>
        <property type="gene ID" value="STSP2_02714"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02714"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PBP_domain"/>
    </dbReference>
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        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5027161478" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30372" checksum="A78584DAB0BCD547" modified="2017-06-07" version="1" precursor="true">MKLTKTLRNSWLVLVAAIMISCPAMAAEEPIDIDGSTTVGPIADAFKEAFEDIHPDASLTIKKTGSGDGAAALVADRTDIAMMSRFMKPKEFKTAVDKGIYPVAHVVAMDGVCVVVHPSNTIDELTSDQVKAIYKGEITNWKELGGPDMKIVPVSRDTASGTYETFHKLVMKKEKMDSGVEYVNSNPQAHARVSKTQGAIAYVGLGFLDRKVKALEIDGVTPTRRTIAKGLYPVSRPLYLFTNGYPKLGSLVHAFCTFHLSEEGQEIIESKGFVPLTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ0</accession>
    <name>A0A1U9NNQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endo-alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.97" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02710"/>
    <dbReference type="EnsemblBacteria" id="AQT69519">
        <property type="protein sequence ID" value="AQT69519"/>
        <property type="gene ID" value="STSP2_02710"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02710"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050110">
        <property type="term" value="F:mucinaminylserine mucinaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_3" evidence="4">
        <location>
            <begin position="51"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_101" evidence="1">
        <location>
            <begin position="273"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_101C" evidence="2">
        <location>
            <begin position="572"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="GalBD_like" evidence="3">
        <location>
            <begin position="822"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1163" mass="130040" checksum="9497077E7D5401EA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR2</accession>
    <name>A0A1U9NNR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dppC</name>
        <name evidence="7" type="ORF">STSP2_02563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02563"/>
    <dbReference type="EnsemblBacteria" id="AQT69374">
        <property type="protein sequence ID" value="AQT69374"/>
        <property type="gene ID" value="STSP2_02563"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02563"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35060" checksum="064992AF2BAFFD7C" modified="2017-06-07" version="1">MSSQNNNKNTTKEKGQSLWADGWRRLKRRKFAMFCLGIIVIYFGLAGFVWFAEMFNLDISLIQYDETVAESYAEPGAEPLEGHSAISTIAGADFLGRSVLRATIYGAKVSLTVALFASVLSVLIGVPLGAIAGYFGGVVDEFIVWLYSTLSTIPYLILMMAFALVLKDKTVFGMKIAGSTTVYLAMGLTSWVGICRLIRGEIIKRKESEYVLAARALGARNHRIIFSHLIPNVFHIVIITFSIRFVAFIHAEVILSFLGLGDPDKPSWGNMISLAKDELSRGCWWQMTSATIAIAIISLALNIFGDALRDSLDPKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU5</accession>
    <name>A0A1U9NNU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69186">
        <property type="protein sequence ID" value="AQT69186"/>
        <property type="gene ID" value="STSP2_02373"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02373"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="393" mass="45030" checksum="378ADC9AEC4D5E4B" modified="2017-06-07" version="1">MGMFDTVGNEKTNLKRNANTLQKLKRMRTALSHCEPDRVPISDFFWGSFIKRWRKDLELPDDANPYYYYDLDWIVTVPNMDPFIRSFETLKEDSEEVVVKTGFGAILRKKFSSPMPEFVDFETDTIEKLEALEFDDPFDRRRYFEAGDNQIAGVGDGFERNSPPWVETVKSLHPDFPVFGSIIECNECLTRLIGPENNMLWIGMHPDRMGKVINRIGQFYLNCAKAQIDAAGGLLDGFVIWGDVAYRNNMFFSPDYWRAYFKPWVKAIAEYAHSKGLMVIYHGCGNVSKILEDYIKIGIDAMNPLEAKADLDAVELRQQYGHRLGICGNSNIQIWETGDKELIRREVLGKLSAAQGGGYIFQSDHSVASNVSGQTYDYIVKLVREHGRYPLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV5</accession>
    <name>A0A1U9NNV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="3">2.4.2.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arnC_2</name>
        <name evidence="3" type="ORF">STSP2_02826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.53" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02826"/>
    <dbReference type="EnsemblBacteria" id="AQT69632">
        <property type="protein sequence ID" value="AQT69632"/>
        <property type="gene ID" value="STSP2_02826"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02826"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099621">
        <property type="term" value="F:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="319" mass="36245" checksum="6CC6BB717A228531" modified="2017-06-07" version="1">MENSAALELSLVIPVFNEEESLRPLYDEITSALRDRDGYEVIFIDDGSTDKSLEVLQSLREGDERVRIIKFRRNFGQTAAMAAGFEHCRGRVVVPLDADGQNDPADIPKLVDKLDEGYDIVSGWRKDRQDKWLSRVLPSRVANWMISKITGVSLHDYGCTMKAYRWDSIKEIRLYGEMHRFIPALASWGGERVEEMVVNHRPRTTGVAKYGLNRTFKVVLDLITVKFLASFSTKPIYVFGGIGGLSGVAAMLSFFTVLWQKFISPDHLSMNRNPLLLLTAMLIITSFQFLLMGLLAEILVRTYHESQGRRIYTIEKIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX7</accession>
    <name>A0A1U9NNX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane transcriptional regulator (Anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02846"/>
    <dbReference type="EnsemblBacteria" id="AQT69652">
        <property type="protein sequence ID" value="AQT69652"/>
        <property type="gene ID" value="STSP2_02846"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02846"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110519" checksum="81D1BBFF9C8055EE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP79</accession>
    <name>A0A1U9NP79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">gpmI</name>
        <name evidence="14" type="ORF">STSP2_02917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02917"/>
    <dbReference type="EnsemblBacteria" id="AQT69721">
        <property type="protein sequence ID" value="AQT69721"/>
        <property type="gene ID" value="STSP2_02917"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02917"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="11"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="92"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="524" mass="58582" checksum="471988B6A64A9021" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP85</accession>
    <name>A0A1U9NP85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">STSP2_02719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02719"/>
    <dbReference type="EnsemblBacteria" id="AQT69528">
        <property type="protein sequence ID" value="AQT69528"/>
        <property type="gene ID" value="STSP2_02719"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02719"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="222" mass="25502" checksum="116682B7CBCADB26" modified="2017-06-07" version="1">MPVHMKHEIDKLKQNLVNLCSVVEEELWQAVKSVKNADADLAAKVIGNDQKIDDREVEIEEECLKILALYQPVAIDLRFIITAMKINNDLERIGDLTVNIAERSQFLANQPQVPIPFDFESMTEKTQAMLRKSVDALVKMDCQIAHEVCMSDDKVDAINRQMYDQVKKEIVKHPDWVEQLIHLLSISRHLERIADHTTNIAEDVIYMVEGKIVRHTTEKFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP86</accession>
    <name>A0A1U9NP86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69731">
        <property type="protein sequence ID" value="AQT69731"/>
        <property type="gene ID" value="STSP2_02927"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02927"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7213" checksum="6D8F5DD8761AB1FF" modified="2017-06-07" version="1">MGKPTVFSVGEGEYMRRVEAVKNYRMGCGAERFLGCLADAVVLVADEFGNEAFDQFDDLSAILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP91</accession>
    <name>A0A1U9NP91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (Mo5U34)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmoB</name>
        <name evidence="3" type="ORF">STSP2_02929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02929"/>
    <dbReference type="EnsemblBacteria" id="AQT69733">
        <property type="protein sequence ID" value="AQT69733"/>
        <property type="gene ID" value="STSP2_02929"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02929"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01590">
        <property type="entry name" value="tRNA_carboxymethyltr_CmoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010017">
        <property type="entry name" value="CmoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027555">
        <property type="entry name" value="Mo5U34_MeTrfas-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08003">
        <property type="entry name" value="Methyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00452">
        <property type="entry name" value="TIGR00452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36905" checksum="38A519E5C54B62EA" modified="2017-06-07" version="1">MTDMLSYFDNFFDHLRTVDAELSDRLRSITADICENISHGDLDRWLGAVESMPNITPSTIDLGSNALRIGKHDDCDDTDLDILRQNLMTLHPWRKGPFSVFGIDIETEWRSDLKWDRVKDAIEPLEGKLVLDVGSGNGYFGFRMIDAGARAVVSIDPFLLFVIQFLALNRFAKCERTAVLPLGIEDVPTDKPSYDAVFSMGVLYHRRDPIAHLRELHNLTLPGGEVILETLVIDEPGEAILEPKGRYAKMRNVWAIPSPRLAAEWMTQAGLHDVRIIDVTRTTAEEQRPTEWMAFESLPNYLDPNDSSKTIEGYPAPARGVLIGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG2</accession>
    <name>A0A1U9NPG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69396">
        <property type="protein sequence ID" value="AQT69396"/>
        <property type="gene ID" value="STSP2_02585"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02585"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030190" evidence="1">
        <location>
            <begin position="24"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="595" mass="65445" checksum="0F3663ADCC5EBEFE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN7</accession>
    <name>A0A1U9NPN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69714">
        <property type="protein sequence ID" value="AQT69714"/>
        <property type="gene ID" value="STSP2_02910"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02910"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="PTHR10176"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="597" mass="68135" checksum="793E9F3662AA1D24" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ0</accession>
    <name>A0A1U9NPQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitamin B12-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">btuF</name>
        <name evidence="2" type="ORF">STSP2_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02920"/>
    <dbReference type="EnsemblBacteria" id="AQT69724">
        <property type="protein sequence ID" value="AQT69724"/>
        <property type="gene ID" value="STSP2_02920"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02920"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="33251" checksum="AF9C27DFDFCA3580" modified="2017-06-07" version="1">MKKWLVLTICFIAWCLAGFYLLGLPEQAEGAAANKPVNRIVVTAPNLTEILFSLGLDEQIVGVTMFSKYPPAAAEKPRIGSFWQLNVEAIIAARPDLILSLDFPRQKNVSQRLAMMGYDTLTVNVETVDDLFRSIERVGQAVDRKTEANNLAGDIRNQLNGIQQRVAGRDRPRVMWVIQRDPLRVAGRETFINEMIELAGGVNAIGKTFHQYPPIGTEMVMGCQPDVIIEPSMTETDVEQIQAGARRHWSKYENLPAVERGRVYSVNGDLVSQLGPRLADGVRQIAQRIHPEAFGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR5</accession>
    <name>A0A1U9NPR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69777">
        <property type="protein sequence ID" value="AQT69777"/>
        <property type="gene ID" value="STSP2_02974"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02974"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40526" checksum="97FCA93F213D661B" modified="2017-06-07" version="1">MSGERSRVLAGSEKRAGGVEVFLDPAKREELMRARMRARAAWVEAQQEKLEAKTREVEGLRGELAAVRRKADEDRVAHAGEVKRLEEKVCRAELDRRSIEEQMAGKDEQIGRLTKEKESALFIGRQKADGLGERVEELEAKLKRAEEANARLAAENDGLRGRLGAWEREIEKAGEAEREKDGEIEELRGRVAELAGEVMELERADEDSRGRIAELERAAEERGAECERLRAELAEVCGQEGEAEVALGACQGMLEALSGKVGFTLAVVDVVSGRRAWVGQDLEGLLGYAKGQFAHVSPELMECVIHPHDADAAGSVSGVDWADVPAERAYRLKGADGRWRWFGELLYPFAYGSGGGVVQALSVQFECAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR7</accession>
    <name>A0A1U9NPR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Marine proteobacterial sortase target protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02697"/>
    <dbReference type="EnsemblBacteria" id="AQT69506">
        <property type="protein sequence ID" value="AQT69506"/>
        <property type="gene ID" value="STSP2_02697"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02697"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="169"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34481" checksum="15F58FBB3A085CCC" modified="2017-06-07" version="1">MDGTGIQDRPEFDDASAGTKSGSNWKRRVNTAAMLGWTVSLIIHVVAIVGIGKIGWMYGGDRGNGDVEVAIVEYESGDELESLGQQEQIDQSVSVAPSADMPEVKVELGALMPTEDAQMRSEVLDSQMLNMDTGTAGLGNAWQEASLSGGGAAGSGGASFFGLEVSGTKFVYVVDRSGSMRGEPLNMAKTELRRSISELEEFAEFFVIFYSGSHIAMPGGELVEATEENKEDCYDWLESITGSGSTDPTSAMELALSLNPDAVWLLSDGQFNSSMSDHITRYNKQRGVVINTIAFLNRSGEAILKQIANKNDGKYRFVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ85</accession>
    <name>A0A1U9NQ85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70069">
        <property type="protein sequence ID" value="AQT70069"/>
        <property type="gene ID" value="STSP2_03271"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03271"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="13031" checksum="483BCA83F2E87557" modified="2017-06-07" version="1">MNDFKCVYCGSNDLKLNTWISCECDVAQNDDGSFYYHNSVEKHDVQLANLGSYECGDCRRSLVFGDRPIHSEDELVEYLKVSPEELRAMEKRYCEESCQIYLDEFFEENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ93</accession>
    <name>A0A1U9NQ93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03306"/>
    <dbReference type="EnsemblBacteria" id="AQT70103">
        <property type="protein sequence ID" value="AQT70103"/>
        <property type="gene ID" value="STSP2_03306"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03306"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19727" checksum="95C511A1F88ED99D" modified="2017-06-07" version="1" precursor="true">MTKTLLLLVGTLCIAGCARDRDAAGKGEESEMTIEITSPAFEEGQSIPARYTDDGVNISPPLNWKGLPEEAKSLAIIADDPDAPAKTWVHWVVYNISPESSGLDEGMAKDEKMPDGTMQGMTDFGSVGYGGPAPPSGTHRYFFKIYALDKKLDMSPGAAKDELLKAMGGHIIAQGQLMGTYSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA2</accession>
    <name>A0A1U9NQA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69898">
        <property type="protein sequence ID" value="AQT69898"/>
        <property type="gene ID" value="STSP2_03098"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03098"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24857" checksum="F96EF819350973F6" modified="2017-06-07" version="1" precursor="true">MKLTDSINFRLVTYMLLPCAAVQAVVIAAQHGHAAYSVSENGPIEWTQFAVLMISGSILLARAYKTTTPQLSRLMAAFPIMAAVRELDKVFDRRIFDGSWQLTVFAILGLTAWYISRHSKKIADQLTTFLRESSSGLMLAAMLIILGISRIAGQQTFWEAVMGENHLTVVGRLVEETLEITGYLILAAAAVEKTFFNLPLSLQNELAEKETIQQRNLIPRKQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH1</accession>
    <name>A0A1U9NQH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapA</name>
        <name evidence="10" type="ORF">STSP2_02953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02953"/>
    <dbReference type="EnsemblBacteria" id="AQT69756">
        <property type="protein sequence ID" value="AQT69756"/>
        <property type="gene ID" value="STSP2_02953"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02953"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31320" checksum="F98DA508D7F2BFDC" modified="2017-06-07" version="1">MFKGSYVAIITPFKNGEVDYETLEKLVNWQIEQGINGLVPVGTTGESPTLNNDEHKKVIETVVKAANGRVPVIAGAGSNSTAEAVEMTEFAKKVGADATLQVGPYYNKPEQEGFYQHFKTIAEAVDLPVILYNIPGRCGAGMTPETIARLADVKNVVAVKEATGSLDQASEIALRCDITILSGDDSLTLPLASVGGQGVISVIANIIPADVRKMTDLILEGKLTEAREWHKKLFGLGKTMLTMATNPIPVKTACSMLGMCTPEMRLPMTPLEEDKKQALKKALQDYGLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ2</accession>
    <name>A0A1U9NQJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03205"/>
    <dbReference type="EnsemblBacteria" id="AQT70004">
        <property type="protein sequence ID" value="AQT70004"/>
        <property type="gene ID" value="STSP2_03205"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03205"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041586">
        <property type="entry name" value="PsrA_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17939">
        <property type="entry name" value="TetR_C_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="28266" checksum="85D6B2C17A0C07A4" modified="2017-06-07" version="1">MTLDALKQTFNMFVLNMCLKVGVSKLARKPEIIDQSNDDTRCRILEIARQHFAEKGFRASSVRAITEEADCNVASVNYYFGSKQNLYVEAFRSVIGNLTEVRVAALEGLLKREHGFTLEELLRTFCRVFIDPLLENGGGRMFMRLMQRELDEKRLPPGLCIDEGMRPVRDAAHEALKRVFPQISTDVSYFCIQSVVGQLVYALQMKTFLSETGYTDWPALDLERTIDHVVHFSAAGIRGCVENTKGSAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK0</accession>
    <name>A0A1U9NQK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70057">
        <property type="protein sequence ID" value="AQT70057"/>
        <property type="gene ID" value="STSP2_03259"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03259"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021341">
        <property type="entry name" value="DUF2958"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11171">
        <property type="entry name" value="DUF2958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11838" checksum="22EF9B85E3DCE5A0" modified="2017-06-07" version="1">MKLLTEEIKRTLPKLYSQEEVTDPMVPLKFFTPDSSFTWLIIEGDEESEGDWLFFCKVVSHLCPEGELGYVRLSDLEEIRGPLGLPVERDLYWEAKPLSKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX5</accession>
    <name>A0A1U9NQX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03222"/>
    <dbReference type="EnsemblBacteria" id="AQT70020">
        <property type="protein sequence ID" value="AQT70020"/>
        <property type="gene ID" value="STSP2_03222"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03222"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="3D" evidence="2">
        <location>
            <begin position="142"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22067" checksum="CBCC5C8B6CD24EF6" modified="2017-06-07" version="1">MSDVLQNIWGGRLNIYSVTAAGLLGLVAVLVFSVFGAQASPGDSEIVMLSNTVEPGLPTGLSQIEESAVPTIFDELGSVTQDTLKEEAAPRSSSAISDKQSEWVTVRMRVTAYCPCAKCCGKHANGITANGHKINWGDRFVASDKMFGFGTEMKIPGYNGGKSIKVKDRGRLIKGNRLDVFYNTHYTAKKWGTRYLDVKVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR30</accession>
    <name>A0A1U9NR30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69976">
        <property type="protein sequence ID" value="AQT69976"/>
        <property type="gene ID" value="STSP2_03176"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03176"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="16087" checksum="90C35F97CFF833EB" modified="2017-06-07" version="1">MTTDKPMGSSYGRERGDLSGAVYIDQLRKYDQTIWYDTRDEEFVKYAEKAATWPEFIEICNRHNRNLTISPNLTYMLSRSQTQFRQIVKDAMAEQDLKPWQLEKLTGVPDSTIYRFLQGASLGSDKLQLILEALGLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRA2</accession>
    <name>A0A1U9NRA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groL_2</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">STSP2_03454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03454"/>
    <dbReference type="EnsemblBacteria" id="AQT70248">
        <property type="protein sequence ID" value="AQT70248"/>
        <property type="gene ID" value="STSP2_03454"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03454"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="567" mass="59807" checksum="B39AB1014F46F332" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRE5</accession>
    <name>A0A1U9NRE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoate anaerobic degradation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">badR</name>
        <name evidence="2" type="ORF">STSP2_03395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03395"/>
    <dbReference type="EnsemblBacteria" id="AQT70190">
        <property type="protein sequence ID" value="AQT70190"/>
        <property type="gene ID" value="STSP2_03395"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03395"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17598" checksum="594650EA9873820B" modified="2017-06-07" version="1">MTLKQELNLDKDFRLGCHEVLLNVYFTAALMKKRATEFLKPFGLTDVQLNVMLLLANQGGGEGLSQARLSEMMLVNRANVTTLVDRMEKAGLVKRTAQQGDRRFNIVKLTSLGRKLLNKVEPRYGKEVQRIMGTLKKSEQKDLMRMLEKMRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRF0</accession>
    <name>A0A1U9NRF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formylglycine-generating sulfatase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT70347">
        <property type="protein sequence ID" value="AQT70347"/>
        <property type="gene ID" value="STSP2_03553"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03553"/>
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    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
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        <property type="entry name" value="PEP_exosort_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PEP_exosort"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <end position="293"/>
        </location>
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            <begin position="38"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31605" checksum="B5C6225BE826548E" modified="2017-06-07" version="1" precursor="true">MKPTLTAVLCIFALTCPASAELIQGIDMELVTIGDAGNPGDTRAAANPVGAGSVDYTYRIGKYEVTNGQWDTFIGLAGKPVGSPIGPYDGDAFWVGENIPANGISWLEAAQFCNYLTSGDKSSGAYLFTGDNTNPGQFLGIDRDTAITEFGTAYVIPTEDEWYKAAYWTGDGYSTYANGTDTLPVEDVDSNYLWDSRETQPWDVGSGKMEQNGTFDMMGNIYEWTETGLDEKRILRGGAAGTHHTDAIGSTYQFELFRTGEYGGVGFRIAAVPEPTTLALLGLGGLLLRNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRG5</accession>
    <name>A0A1U9NRG5_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Dipeptide chemoreceptor protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">tap_4</name>
        <name evidence="5" type="ORF">STSP2_03514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03514"/>
    <dbReference type="EnsemblBacteria" id="AQT70308">
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        <property type="gene ID" value="STSP2_03514"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03514"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="355"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="648" mass="70421" checksum="C2FA03CD8E7C5215" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG27</accession>
    <name>A0A1U9NG27_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yrrB_1</name>
        <name evidence="7" type="ORF">STSP2_00021</name>
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    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66883">
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        <property type="gene ID" value="STSP2_00021"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00021"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
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        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="751" mass="85531" checksum="23000E5B27959ADF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ0</accession>
    <name>A0A1U9NGJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67053">
        <property type="protein sequence ID" value="AQT67053"/>
        <property type="gene ID" value="STSP2_00193"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013205471" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="157"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="735" mass="82240" checksum="2BE87F9D7D89AB4B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ3</accession>
    <name>A0A1U9NGQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00123"/>
    <dbReference type="EnsemblBacteria" id="AQT66985">
        <property type="protein sequence ID" value="AQT66985"/>
        <property type="gene ID" value="STSP2_00123"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00123"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40385" checksum="F1F179BBD9500F9D" modified="2017-06-07" version="1">MAENTRTVRAFDYKTVLLTFGCVAVFCFFGTVMGVSNFCSTVMETAHDLLINTVLLIVSISVLAGGFGAFLSEFGILAMLNWILAPFIRLLWGLPGAAVMGAVSTYMSDNPAVIALANDKEFIRYFKKYQKPALTNFGTSFGMGLVLTAFMMSKGFFREAIIGNVGAVVGSIVSTRIMLAFCKHEFNGNGYHIESDGDPAILRYRQIREGGVLQRAMEAVLEGGKEGLKMGAQIVPGVLVVCTLVLMLTFDAGHNGYDGSAYQGIPVLSKIGALFAKPMQLLFGFESPDAIAFPLTSLGAAGAALSLIPRMLAENLIGPNEIAVFTAMGMCWSGYLSTHVAMMDALGYRKLTLKAILSHTIGGITAGVAAHYIFVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH02</accession>
    <name>A0A1U9NH02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sat</name>
        <name evidence="1 3" type="synonym">cysC</name>
        <name evidence="3" type="ORF">STSP2_00018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00018"/>
    <dbReference type="EnsemblBacteria" id="AQT66880">
        <property type="protein sequence ID" value="AQT66880"/>
        <property type="gene ID" value="STSP2_00018"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00018"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20575" checksum="C75D8EA9211EA2D5" modified="2017-06-07" version="1">MTKTDSEHSRNGDTGLVIWLTGLSGSGKSTLADRLYEVLNKKLPRVEKLDGDVIRSYFPSTGFTKAARDEHIKRVGFIASLLEKHGVTVIASFISPYSDTRKLVRNMCGNFLEVHVKASIEECERRDVKGLYKKVRAGEITNFTGIDDPYEEPVNPEVVVDTEKLTVEEAAEKILQAISLSCEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH48</accession>
    <name>A0A1U9NH48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67064">
        <property type="protein sequence ID" value="AQT67064"/>
        <property type="gene ID" value="STSP2_00204"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00204"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17119" checksum="2EB24E32C5CC1A31" modified="2017-06-07" version="1">MAISSVQQRRPVLAGKNTCKTASRHKPKQYHNHPQFSSNLYPPKATLRCHQPRQSQTPLPVIPDPDPGSSMKKPSRSDSLASPPVTPAASHVNRQPNIKYVIRLRRTQRTPRSRIHAHQRMQPTKLRAATHLPKKSPKPAPRSSRYNRATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH56</accession>
    <name>A0A1U9NH56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67261">
        <property type="protein sequence ID" value="AQT67261"/>
        <property type="gene ID" value="STSP2_00404"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00404"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50975" checksum="D2C22B322718E06D" modified="2017-06-07" version="1">MFTDHGQKKTAVSQIAMLALFIIGLILASVVTVSTNKIRLTDPIPLFQSGLSVSLPKGRAWQSPYKWQFDPETNRFETLAGIRMGNKIDTMAHWTYALAAGDLSASQRLQNKLGPDPGNITEKGTITVGSLDFAWAQLSTSGRSPDTIIAAASLPSNRSLTLTIEAIAQPKVATDLFNKLIQSAKYTAPENVRQGEQFISQIRESGLHRLLLTDLGPSLDSIYRISQPEDAKLKNIRGFSVMSFDYESQQPTATVTGQGMMSISMEKGSLSEHHEFRFADSLESFSWRSQYQNGADRRPGQTALELKDFNQLTLTYLSGPRRLQGKQTELTLSPATLPELFLTSAARFLLDSQYDRIMLEILTTQGWIAPAQLSQIPPVELPTDDHPDISYGIAVDFTHGNGTPLRFYYNNDKDLILQQQLMPDTVTWIKADRKELLENVTPNQAETIRQILKPVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH75</accession>
    <name>A0A1U9NH75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67108">
        <property type="protein sequence ID" value="AQT67108"/>
        <property type="gene ID" value="STSP2_00249"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00249"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22750" checksum="DA7C73BF0C4FEE40" modified="2017-06-07" version="1">MAGIKLAMGLTGGDFWARPQGCVILCMRDARFEDEKLGRVFNSNAEEFVLSEIRPEAVGNMIYAYVRRINFCGQEEAGLDGCICLIADENGKWVNVPAHGVLDITAVRESSANIQLQILYISSENVTARFYVYDGSATEENKIAEEELGRSGVHSFRIVLPDEQTSELQLILVNDEGAILYRRDVSIQKAKTMQTEIYGITAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB5</accession>
    <name>A0A1U9NHB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67321">
        <property type="protein sequence ID" value="AQT67321"/>
        <property type="gene ID" value="STSP2_00464"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00464"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="32122" checksum="18AC3BCDC37E6D60" modified="2017-06-07" version="1">MSRTKNTVAIPGVKNRNAMIDFIRHLLAVPLQMLVFAARILPIHRLPLLKAIWDLTADPQWGARLIKETAFVKSLADARRLTDRLLSQKNDGRLYLAIGQLELDPGGDPVAAYNWIHRARQTDCTNQEWLLYLELILSRHLPQCDPGDIADRILARNDLPMHYTATALSIKAQLAISNNDFDRADRILDRMLEVQDDANVHFLKWVCAQARNDEQKAEYHRRRFAKQTSADQYFLTLAHGWLRLHNEPNARECLSFAQQKGVTREQIEKFDAQLVKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD7</accession>
    <name>A0A1U9NHD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PEP-CTERM system TPR-repeat lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67187">
        <property type="protein sequence ID" value="AQT67187"/>
        <property type="gene ID" value="STSP2_00330"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00330"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="640" mass="72130" checksum="67FAC50050220299" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE6</accession>
    <name>A0A1U9NHE6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH</name>
        <name evidence="10" type="ORF">STSP2_00496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00496"/>
    <dbReference type="EnsemblBacteria" id="AQT67352">
        <property type="protein sequence ID" value="AQT67352"/>
        <property type="gene ID" value="STSP2_00496"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00496"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17876" checksum="1C87D62A4BC4A7CE" modified="2017-06-07" version="1">MKHILSALVQNEPGVLAHVSGMFAARAFNIDSLAVGRTDDPKLSRMTIVVVGDDRMVEQVRKQLAKIVSVVKVQDFAGKDTVARDLMLLSVAAPAEKRPEIFALIEMFNAKVVDIGPKFVMVEVSGPEAKIEAFIEACKPYGVKNVARTGTIAMPRQPRSNSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF1</accession>
    <name>A0A1U9NHF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">STSP2_00497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00497"/>
    <dbReference type="EnsemblBacteria" id="AQT67353">
        <property type="protein sequence ID" value="AQT67353"/>
        <property type="gene ID" value="STSP2_00497"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00497"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36364" checksum="D4B75BB3292D6BE2" modified="2017-06-07" version="1">MANIYYENEAPIDALKGKKVAVIGYGSQGHGHSQNLRDSGIDVAVAELEGTDNFNLAKEHGFNPTDIKTAIDGAALIIITLPDEVQAKVYNSDIAPNLQPGQTLGFCHGFNIIFGYIQPPENTNVVMIAPKGPGHLVRAEYEKGGGVPCLIAVEQDATGDAKDVALAWANGIGGARAGIIETTFKEETETDLFGEQVVLCGGLTALIKAGFETLVDAGYQPEIAYFECLHEVKLIVDLMYQGGLSYMRYSISNTAEYGDLSRGSRIITDETKAEMKKILSEIQTGEFAKEWVAEYQGGMKKFNELYEKDYTSKLETVGRKLRSMMKWIDAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF8</accession>
    <name>A0A1U9NHF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00341"/>
    <dbReference type="EnsemblBacteria" id="AQT67198">
        <property type="protein sequence ID" value="AQT67198"/>
        <property type="gene ID" value="STSP2_00341"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00341"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10318" checksum="B14F83C2E37B9418" modified="2017-06-07" version="1">MPTVKDVVVKKPSEAEMAEAKSWPTWGCEASEFDWDYTQTETCLLIEGKVVVTDRPDSGESVSFAAGDMVVFPEGLACVWKVSAPVKKHYKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI6</accession>
    <name>A0A1U9NHI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ORF">STSP2_00525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00525"/>
    <dbReference type="EnsemblBacteria" id="AQT67381">
        <property type="protein sequence ID" value="AQT67381"/>
        <property type="gene ID" value="STSP2_00525"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00525"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9959" checksum="33691406C1C6E986" modified="2017-06-07" version="1">MAHSLSAKKRVRQNAKRNARNRGRKGALRKQIKTFEVLVKEGDAAKAQEQYKLVEKLLDKLSCTPTLHKNTASRMKSRLAKQLNTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN5</accession>
    <name>A0A1U9NHN5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67268">
        <property type="protein sequence ID" value="AQT67268"/>
        <property type="gene ID" value="STSP2_00411"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00411"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21277" checksum="92F4233BF688D1CE" modified="2017-06-07" version="1">MPYLEALVALFAIVDPIGNIPMFLHVADNVPEGQEAKAFNTAVLVGLTVLLVFAFAGKAILNHVFHIELAALQVAGGLLLIITAVDHLIFGILKKGVAINKSAVSATELGCVPLACPLLAGPGAMVTSLTMLEKHGPLAVIPAIVTIFLGLWLLLRFLEPVHRFLGDLVSTAFSKIMLVFISAIGVHMMITGLKAYFTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI24</accession>
    <name>A0A1U9NI24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wapA_6</name>
        <name evidence="2" type="ORF">STSP2_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67592">
        <property type="protein sequence ID" value="AQT67592"/>
        <property type="gene ID" value="STSP2_00740"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00740"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="219" mass="25094" checksum="5A2EB637B8040DD1" modified="2017-06-07" version="1">MYTGRRCDPETGLYYYRARMYDTELGRFLQPDPIGYADGMNMYAYTANNPINFVDPWGLDAEHRKGKRKSTKNKHEKGQRRKQQVRKDKKRQKHKKWKSHKIEVAGGAGLFYLAWKKVRHGATVAARGGAKLAGGVASILFLFGDDMCTDLSAGTIYPWLPREFEIVRNDLSVEALEEIMGYIGIEQLTEEEMYQIIDKWDNQKDCDKDGAEGSLTGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI90</accession>
    <name>A0A1U9NI90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane assembly lipoprotein YfiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67643">
        <property type="protein sequence ID" value="AQT67643"/>
        <property type="gene ID" value="STSP2_00791"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00791"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012007532" evidence="3">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="275" mass="31605" checksum="6262B5D55D7ED449" modified="2017-06-07" version="1">MTKTIYSLTLILLVVMAAGCGEQVQKELYEEPSGRVVQEGISFAAPTAEEVELVEYMAAQRSSYRKSLQALADYYKRTGDATKLRWARQEVDALNEVPRYSYIMAAETVDIGQRAVNEIEAANQLYNEGLSIYRSTAFVPVLADEGKLRQALAKFNAVISRYPTSDKVDDAAYRAGRIYEHFDNYEIAVTYYKRAFKWDPNTPYPVRYRAAFLLDHRLHDRKEALTLYRDAVEKESSYFDNMEYARNRILQLTQPEREVSPEVEETEPVEGQVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI91</accession>
    <name>A0A1U9NI91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ORF">STSP2_00605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00605"/>
    <dbReference type="EnsemblBacteria" id="AQT67458">
        <property type="protein sequence ID" value="AQT67458"/>
        <property type="gene ID" value="STSP2_00605"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00605"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="335" mass="36512" checksum="479AE4B822945C71" modified="2017-06-07" version="1">MVRVAIVGASGYTGVESIEILLRHEQAEVTYLSAMTETGRVDEIFGRLRGRCELEVEHLDFNKLGEVADVVLCCLPHKVAMGYVPKMLDMGLKVVDFSADYRLRDLEAYEKFYKVEHTDRANVAKAAFGLPELFRSKIEGAQLVANPGCYPTGAMLAVAPLLKNGYIETSGMAVNSVSGASGAGKKPSKLCHYPNLNENLVPYGVGTHRHMPEMEQIASEVAGTDVELLFQPHIGAFDRGILSTVYCDPTRELSNDDLADIYRAFYKRERFVSVLGQPPAVKNVAGTNYCQVFATAVKGKIVCFSVIDNLVKGASGQAVQNMNIVCGFDEAMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC2</accession>
    <name>A0A1U9NIC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfoacetaldehyde reductase</fullName>
            <ecNumber evidence="1">1.1.1.313</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">isfD</name>
        <name evidence="1" type="ORF">STSP2_00827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.313" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00827"/>
    <dbReference type="EnsemblBacteria" id="AQT67679">
        <property type="protein sequence ID" value="AQT67679"/>
        <property type="gene ID" value="STSP2_00827"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00827"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="26029" checksum="54CD99721CD17AC5" modified="2017-06-07" version="1">MPKAIIIGATSGIGRACALELADRGYVVAATGRRTEKLEQLKDEIGINCHIRRMDVTDTEDARKGFLELAEKMGGCDTVIINSGIGYADNRPKWANEKSTIDVNVTGFVALASRALDYFTEHGGGHIVGISSIAGLRGGPSCAYNASKAFVSNYMDGLRFTADKNNIAVTDVRPGFVETPLIEGRDRLFWVASSQKAAKQIADAMQNKKKRVYITRRWTIIAALIKILPDWAYFRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG8</accession>
    <name>A0A1U9NIG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67711">
        <property type="protein sequence ID" value="AQT67711"/>
        <property type="gene ID" value="STSP2_00859"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00859"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012097997" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17559" checksum="3D55DB9A19E5FAF9" modified="2017-06-07" version="1" precursor="true">MRRMVLVVFCVVTMLCSAGCMDKILAWNEDTTTDLLGRKADLVATLAEIDAVADLKSDDGKYKGFMVIAKRPGLEIPAQERLIKRVYEELYFDDAKGDVLVTLVENTNFSHEAKREIMVGLNNIESEEEKIRVLDAVQFRRIGVNAAMGERMGGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH7</accession>
    <name>A0A1U9NIH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_00534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00534"/>
    <dbReference type="EnsemblBacteria" id="AQT67390">
        <property type="protein sequence ID" value="AQT67390"/>
        <property type="gene ID" value="STSP2_00534"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00534"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="entry name" value="PTHR13460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234086" evidence="8">
        <location>
            <begin position="26"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67N" evidence="9">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="10">
        <location>
            <begin position="565"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116849" checksum="99D54C4E3D67F3AA" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII4</accession>
    <name>A0A1U9NII4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">STSP2_00783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00783"/>
    <dbReference type="EnsemblBacteria" id="AQT67635">
        <property type="protein sequence ID" value="AQT67635"/>
        <property type="gene ID" value="STSP2_00783"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00783"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21123" checksum="E73DAC46DF445620" modified="2017-06-07" version="1">MARTAELKRETNETKISIEMNLDGAGRYDVDTGVGFFDHMMAHLSKHSKIDLTLKAKGDLEVDAHHTVEDVGICLGQCLNDALGDKKGIARYGHSSLPMEDALANVALDLSGRPFCVYNAEYRTERIGDFDVELIEEFLRAFTNAGRFNLHVNVPYGTNSHHIAEAIFKAIGQAFGTAAKIVGKEIPSTKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ0</accession>
    <name>A0A1U9NIJ0_9BACT</name>
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        <recommendedName>
            <fullName evidence="1">Aminodeoxychorismate synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pabB</name>
        <name evidence="5" type="ORF">STSP2_00898</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT67749">
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        <property type="gene ID" value="STSP2_00898"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00898"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
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        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
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    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="4">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="3">
        <location>
            <begin position="196"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="480" mass="53290" checksum="D576A84B23A4CCF4" modified="2017-06-07" version="1">MKNCKVKIKRVEFAAELEGVTEVFAKLDGAAVLGGNEGGCGANRFSAWMAEPVEIFEFRLGEDDPFGRLESVLGKYKLSGPMPEDLPAGMFACGWVGFFGYELGRYIESIPDTAVDDLGLPVVRLGFYDRAVCYDHVNREWYAAAGEFEGEEWTAEEKFRELEKLIERSCECRAATDADADMEGVEPANIECNISRREYFDAFERIKEYIHDGDVYQINFSQRFRCDYAADPVKLYQWQNRHNPSPYAAFIKGEEWSVVSASPELFVRVQDGKISTKPIKGTRARVSGADAERINKKHFDQLAGCEKEQAELNMIIDLERNDLTRVCRYGTIKVVQPRTIEAYPTVYHAVATVEGELREKQGRGTVCDILRAMFPGGSITGAPKIRSMEIIDELEPTARSVYTGSIGFIGLDGSACLNIAIRTVIIRGNSAYVQTGGGVVADSQPQAEWDETITKARALLAGIAAVGRTRVSDPEIKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ00</accession>
    <name>A0A1U9NJ00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase DbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT67909">
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        <property type="gene ID" value="STSP2_01061"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01061"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="144"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120692" checksum="926A0041971C9C45" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ27</accession>
    <name>A0A1U9NJ27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease 8</fullName>
            <ecNumber evidence="2">3.1.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">recE</name>
        <name evidence="2" type="ORF">STSP2_01073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.11.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67921">
        <property type="protein sequence ID" value="AQT67921"/>
        <property type="gene ID" value="STSP2_01073"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01073"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024432">
        <property type="entry name" value="Put_RecE_PDDEXK-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12684">
        <property type="entry name" value="DUF3799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3799" evidence="1">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="30507" checksum="5579ACEBEE749697" modified="2017-06-07" version="1">MHQLTRPDWLIEEPDEVYHGKAKEFLSSHQLNDFRKCPYLYWKKHSGLIADKDSSAYAFGRAAHTLILEGRQTFEQRYAVGGPINPRTGKPYGSGTKAFAQWSADQGKPVVTDDEFVILEMMEQAVLTHPCAPKFITSGFAEGVCRSPYLGIPSQIRMDYLHPSYGIVDLKTCDDLTWFESDARRYGYLHQMAFYRAVLKETMGSKASVHILAVEKKQPFRCGIWKVSGDALDFAQAENESAIRLLKECCSEQIWPTGYEDIRIYDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ36</accession>
    <name>A0A1U9NJ36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00986"/>
    <dbReference type="EnsemblBacteria" id="AQT67835">
        <property type="protein sequence ID" value="AQT67835"/>
        <property type="gene ID" value="STSP2_00986"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00986"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010716536" evidence="1">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="176"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="520" mass="54728" checksum="669B55C4564D6422" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ72</accession>
    <name>A0A1U9NJ72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">polA</name>
        <name evidence="15" type="ORF">STSP2_01137</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01137"/>
    <dbReference type="EnsemblBacteria" id="AQT67983">
        <property type="protein sequence ID" value="AQT67983"/>
        <property type="gene ID" value="STSP2_01137"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01137"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="325"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="677"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="920" mass="102864" checksum="14F0CB4970A630E3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ82</accession>
    <name>A0A1U9NJ82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/sarcosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.156" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01147"/>
    <dbReference type="EnsemblBacteria" id="AQT67993">
        <property type="protein sequence ID" value="AQT67993"/>
        <property type="gene ID" value="STSP2_01147"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01147"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052730">
        <property type="term" value="F:sarcosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28586" checksum="598CD77BB6D1D5B9" modified="2017-06-07" version="1">MVHKEWHEDDSFWETFQPVLFGEKVMSRSASEIDKITSLLDLNGSGQILDLCCGVGRHSLELARRGFSVTGVDRTEKYLDEARACAEDENLAVDFLNHDARTFAKPETYDIAMIMDRSFGYFDNAEDDRQVIENVHASLRPDGKFIIELTGKESFACFFQQRDWYEEDGAILLSERQAVDDWSAMNCRWILLRNGYRCEKNFQIRLYSAYELTELLKSSGFKNVRTYADLDGKTYHPTAKRLIAVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF4</accession>
    <name>A0A1U9NJF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68062">
        <property type="protein sequence ID" value="AQT68062"/>
        <property type="gene ID" value="STSP2_01217"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01217"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7345" checksum="D01A1B470114F132" modified="2017-06-07" version="1">MSSEKPFNDLVPKDFAANLAFRRERIWLGWSDEKAAQERSANVSPIICLLLSQDSHRNCIGLCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ6</accession>
    <name>A0A1U9NJJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoC1</name>
        <name evidence="3" type="synonym">deoC</name>
        <name evidence="4" type="ORF">STSP2_00899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00899"/>
    <dbReference type="EnsemblBacteria" id="AQT67750">
        <property type="protein sequence ID" value="AQT67750"/>
        <property type="gene ID" value="STSP2_00899"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00899"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24353" checksum="A93631C9422FEA83" modified="2017-06-07" version="1">MTDKELAAYIDHTLLDPVATRGEIEQLCDEAIEYRFHSVCVLPRWTSLAAEKLRGSEVVVDGVAGFPFGADSAKIKAAQTKEVIMAGADEIDMVADLPSIIEGNSRYLRRDIQAVMKVCRSFRPAVVLKVIIEASALTEKQIRFACQECEDIGVDYIKTSTGMHKSGGASVEAVQIMAESAPGCKIKAAGGIRTADDAVAMIEAGASRIGCSASVRIIEEFRQANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM5</accession>
    <name>A0A1U9NJM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium ATPase proteolipid component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ntpK</name>
        <name evidence="7" type="ORF">STSP2_01161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01161"/>
    <dbReference type="EnsemblBacteria" id="AQT68007">
        <property type="protein sequence ID" value="AQT68007"/>
        <property type="gene ID" value="STSP2_01161"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01161"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="16780" checksum="D529F96F5344E251" modified="2017-06-07" version="1">MEGLGNALALIGAATAVFAAGAGSGIGIGHAARSATGVLTDKPERYGLNFIMVVLPGTQGFYGFLAGFLVLLNMNVLGGGDVLQLTWQQGLQVIGACLPIAITGLISAIHQGKVCASGVLMAAKRPEMAFKAGVVYAVMVEVYAVLGLLISMFVILMGINWPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP3</accession>
    <name>A0A1U9NJP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68141">
        <property type="protein sequence ID" value="AQT68141"/>
        <property type="gene ID" value="STSP2_01296"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01296"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012753017" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="16003" checksum="5E3170B10FCA5064" modified="2017-06-07" version="1" precursor="true">MKKGRKRTSLILLAAILLAISAHRALKNFQIQQETTRWYAKAITAFNDETTPEDARDWLTDNGFELMIWNPNAQKGWIGKQTVQQPDSTSDYYLVQGSKPLSEDIWLDIKFTFDTDLIPQKARYNTRTHPINSSQSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT9</accession>
    <name>A0A1U9NJT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">omcB</name>
        <name evidence="3" type="ORF">STSP2_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00925"/>
    <dbReference type="EnsemblBacteria" id="AQT67776">
        <property type="protein sequence ID" value="AQT67776"/>
        <property type="gene ID" value="STSP2_00925"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00925"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012437186" evidence="1">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="277"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="398"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="55249" checksum="692740EDA05D477E" modified="2017-06-07" version="1" precursor="true">MKIKHVLTITLLIAAVSLTACCPREKTARVEEPMREPDPCAASAMAKAETVFPRDIRNVVQLEKMAPEQIVAGQPFEYRLKVTNLTSETISNVRVSDTIPQNLTVTQSEPEMASMEERTAHWMIGELEGNGTRMITVTARASGTGMVRSCASVTYDSPLCAQMNIVQPKLRITKIAPTEALSCDRIPVKYVVTNNGTGYACDLQITDPLPEGLVDAEGNDQVSFNIDSIGPNESKEFSIMLDATTTGTFSSKATVASANSGTSESNMTRTEVTEPKLQITASAPQRQFMGKSITYQVTVKNTGSGPARDTTVVANVPDGIDFETATDQGEFTTSSPGKVTWNVGTIPPNEQKTVTMKIRYNREGELVSRVTAVAHCAEEVEQTASTSVTGIPALLTEVVDTNDPVEIGENTTYRITITNQGSTAGKNIQITCALPESMQYVSSTGPTTASAEGNTITFKPLMSLAAGQQQTWTVNIKALQEDDSRFEVKVTSDTLTKPVRETESTMLYQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW3</accession>
    <name>A0A1U9NJW3_9BACT</name>
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        <submittedName>
            <fullName evidence="4">2-hydroxyglutaryl-CoA dehydratase component A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hgdC</name>
        <name evidence="4" type="ORF">STSP2_01368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01368"/>
    <dbReference type="EnsemblBacteria" id="AQT68212">
        <property type="protein sequence ID" value="AQT68212"/>
        <property type="gene ID" value="STSP2_01368"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01368"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28007" checksum="5DF27C8846F59BD8" modified="2017-06-07" version="1">MICAGIDAGSRTIKAVLLDAERMVVLGEGVVDQGIEQKRLARLLLERIAEESGIGMDDIAYTVATGYGRGMLDFADKTITEITCHAAGVTYHLPETSVIIDIGGQDSKVIHLEADGTVYDFSMNDRCAAGTGRFLELVANRTEVPIERLGELASKSRSPAAISSMCVVFAETEIVGLMAEGVETSDIIAGVQFSIAERIAAMSGPVNGGGVTFTGGVAMIPGMRETLEDAVGAEVRVCSSPQKTGAMGAALLAARRVRNINKIGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC2</accession>
    <name>A0A1U9NKC2_9BACT</name>
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        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68184">
        <property type="protein sequence ID" value="AQT68184"/>
        <property type="gene ID" value="STSP2_01339"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01339"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012730660" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26902" checksum="7AF7754910BCE79A" modified="2017-06-07" version="1" precursor="true">MMNRKLLLIGLAMMACLIGTSNAMPILDSQNFDWKYEMDVQPNNQDLNNSGSDDFWDGGALTVSNGVAIGTGDDTYFRTDYGGSIWRDEITGAAFTIEFSVQILETGEEGTAGTMGMYARNLETGGGPYLNVARSGQTLINTQATLDLGSQDNTDGQHVFRVAREGDGSVWVYRDGVMLNPNGQPIVGDLSVFNNDIFQIGDIWSTGHSGDYEIDYVRLTDGAYAPVPEPATMLLLGLGGMLTLRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD5</accession>
    <name>A0A1U9NKD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfp pilus assembly protein PilX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68393">
        <property type="protein sequence ID" value="AQT68393"/>
        <property type="gene ID" value="STSP2_01553"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01553"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025746">
        <property type="entry name" value="PilX_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14341">
        <property type="entry name" value="PilX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PilX_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="455" mass="48106" checksum="D4617FAD60B82FCA" modified="2017-06-07" version="1">MSSKNISTNRGNRRGIALVTAMIFLILFSSIAVGFMTFSTQNASIADNYRDGNRAFACAQSGAEVMRHWLDKVAMDGTIDDNLRYDTLVSSLDTIFSNNGITSFNTTYDGSCYSVADVSLGEGESFSAEILPVDNDTVQMNITGMANGLERTIACNYTFGVRETSVFDFGVATRGTLELSGNIDLDGTNISVEASVYIESPESIALSIIGNSRIAGDVNITNEDGDVNLQGGQAEIGGDVFTGVPPTEFPAPNPGSFEKYLSGQIIDSTTDLSADATFTNARVLAGTNPHFSGDVTIEGVLYIETPNQVTFGGNVDIIGVIVGDGDVTDDSQTNTIDFTGNVSSTSVASLPLESQFDGLRDETGTFLMTPGFSISMGGNFGTLNGCIAANGVDFYGNAGGTIEGSIVNYSQNQMTFSGNSDLYFNRSGVTEVPAGFEPEIIMHYDPTSYSEITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL0</accession>
    <name>A0A1U9NKL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01637"/>
    <dbReference type="EnsemblBacteria" id="AQT68473">
        <property type="protein sequence ID" value="AQT68473"/>
        <property type="gene ID" value="STSP2_01637"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01637"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="28423" checksum="9CE8D568B39FECBE" modified="2017-06-07" version="1">MARKKGFTLIELLVVISIIALLMAIMMPALSMVKERAKRVICGSNTKQVGIGLFTYAQSYDDKLPPQYGNEPWEAVLAYYPDGSHNPVRTQLAILYEEKIVGNPEVFYCPSQPRHSDYPIPYYYDFYTDNGTVEWGSEFIPIPGLDGHELIRTSYNYWLHGQKKTSALSRNAILVDNCQEWEVVPHRKGSSGDPQGLYALFGDGHANFATRREIFDDDLWPKDFRTVFNGPGNDTEKFELILKEIEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM8</accession>
    <name>A0A1U9NKM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
            <ecNumber evidence="3">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nox_1</name>
        <name evidence="3" type="ORF">STSP2_01507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68347">
        <property type="protein sequence ID" value="AQT68347"/>
        <property type="gene ID" value="STSP2_01507"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01507"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="TM1586_NiRdase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="19008" checksum="D927C12B5D05C2BD" modified="2017-06-07" version="1">MDVMQAIEKRYSCRSYHPDAIEEDKLGRILEAARLAPSARNQQEWRFVVVRDEHTRRKLSVAAANQDFVAQAPVVIVGCTMTDRLMRCGQPSGVIDTAIAMEHIALQAVEEGLATCWVGAFYPDKVKPILNIPDEVTVVELMSLGYPADEPVGTPRCDMPKIVSFDSWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU2</accession>
    <name>A0A1U9NKU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68435">
        <property type="protein sequence ID" value="AQT68435"/>
        <property type="gene ID" value="STSP2_01599"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01599"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025130">
        <property type="entry name" value="DUF4056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13265">
        <property type="entry name" value="DUF4056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="41825" checksum="4684077B157289B9" modified="2017-06-07" version="1" precursor="true">MNTSKLTVRIIVSIAAVFLTTLTTGCSLTNEPRPRLGSYATDTIGTNFLDMKSLGNHSHGIFLGEGNGIAYTCRGGHIDIAHLRISAEYTKYLHDKVQSCLTDGDDSFTFTMNVEPTRYYVKLDYPPNWDDLSAERKKQITDQIALDLGQYLTFTMVTWHEVLTWFNFKGMGVLPEFPSAFSWEDSYSNLLGTRISAAAIKADESHFDKAVTLELEKEMEHLGIKSRKFARQAAAKMRGEWYVGAVLVDMRERNMDIGLDDGYVTPTLVPGVCENAQPLSYPAPTLDSLTRNGFAIDLEVQSNIMEMGRILKVVKQNPETGRIDLITQLPVMMRHIEQEAISRGYNTRPSNGSTNSNPERSTAADTTKTSPTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU4</accession>
    <name>A0A1U9NKU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68210">
        <property type="protein sequence ID" value="AQT68210"/>
        <property type="gene ID" value="STSP2_01366"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01366"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8441" checksum="90031D6CDA9DE3C2" modified="2017-06-07" version="1">MGPFEAKAQSVSLTITDGVAKLSDSADQGSNNDENLELADVDETEKPNYVVIIVIGTILIVSAVVILTKNRKGKGNPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV0</accession>
    <name>A0A1U9NKV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrophosphatase PpaX</fullName>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppaX</name>
        <name evidence="1" type="ORF">STSP2_01731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01731"/>
    <dbReference type="EnsemblBacteria" id="AQT68563">
        <property type="protein sequence ID" value="AQT68563"/>
        <property type="gene ID" value="STSP2_01731"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01731"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21440" checksum="F1A9C6C99832A459" modified="2017-06-07" version="1">METDRYEIMPIKAVIFDLDGTITQPCLDFDLIRQEMGLAEDAGPILEYLENMPPDDRKQAETILERHEDQAAVESCLNNGAKETIEELCDRGIKVGILTRNKRTNAIAVRDKHGLHFDAVIAREDGPAKPDPHGVLALCKEFGTSPRETILVGDYLHDLLTAKAADVTAILIETHKDADKFWLDPEKLYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV6</accession>
    <name>A0A1U9NKV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">glnS</name>
        <name evidence="12" type="ORF">STSP2_01514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01514"/>
    <dbReference type="EnsemblBacteria" id="AQT68354">
        <property type="protein sequence ID" value="AQT68354"/>
        <property type="gene ID" value="STSP2_01514"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01514"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="350"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="589" mass="68450" checksum="048A1F2471EDFA54" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY0</accession>
    <name>A0A1U9NKY0_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_01761"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="29" mass="3623" checksum="CF5470DB2F5C5669" modified="2017-06-07" version="1">MDELILRGLYYVCYFIDSERKERYGYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ5</accession>
    <name>A0A1U9NKZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68579.1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="34026" checksum="FCFAB6655093807E" modified="2017-06-07" version="1">MNRNKKIEGTYILDGMLEGYITDANDEECLRRFLRQAKECKLHFHLSTEGERFTLLPDKKTNRLPQSVESVSSLLKHPLENLLACFAADDAVKFISTLRSIEYSPDTEKQALYCIGPDGGLMIEQRSVPADTVPPAAEMPLEDKLKIGAAAFAILAIVVGISAFFVPYGKIASDIYEGLKPYKIEDVSVQAENFHEYFTVEDIDRDRQNNQLILLCRKTPEFPASADKLNEQWLQSRDNLYAAMAVEALARKSLSCEYFDKEGELIGRSICRMRDIDDQPQLFAVALPFNRSIKKIEIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL09</accession>
    <name>A0A1U9NL09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT68196">
        <property type="protein sequence ID" value="AQT68196"/>
        <property type="gene ID" value="STSP2_01351"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01351"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="446"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="561" mass="60752" checksum="5FA2EAF061FC9954" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL47</accession>
    <name>A0A1U9NL47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
            <ecNumber evidence="6">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">treS</name>
        <name evidence="13" type="ORF">STSP2_01618</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EC" id="5.4.99.16" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01618"/>
    <dbReference type="EnsemblBacteria" id="AQT68454">
        <property type="protein sequence ID" value="AQT68454"/>
        <property type="gene ID" value="STSP2_01618"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01618"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012811">
        <property type="entry name" value="TreS_maltokin_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02457">
        <property type="entry name" value="TreS_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1108" mass="129453" checksum="23DEEA374B4F883B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL64</accession>
    <name>A0A1U9NL64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Tyrosine-protein kinase ptk</fullName>
            <ecNumber evidence="21">2.7.10.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ptk</name>
        <name evidence="21" type="ORF">STSP2_01479</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.-" evidence="21"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01479"/>
    <dbReference type="EnsemblBacteria" id="AQT68320">
        <property type="protein sequence ID" value="AQT68320"/>
        <property type="gene ID" value="STSP2_01479"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01479"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="18">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="20">
        <location>
            <begin position="381"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="19">
        <location>
            <begin position="524"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="286"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AQT68320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="725" mass="79872" checksum="058CA534DE44C220" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH2</accession>
    <name>A0A1U9NLH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">exbB_1</name>
        <name evidence="10" type="ORF">STSP2_01580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01580"/>
    <dbReference type="EnsemblBacteria" id="AQT68420">
        <property type="protein sequence ID" value="AQT68420"/>
        <property type="gene ID" value="STSP2_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01580"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="124"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31120" checksum="836D3E51A99CBEC7" modified="2017-06-07" version="1" precursor="true">MKTFHKKNGKAGPGGPGALLTLVICIACVTATLFAAEQGGGGDGAGQKSLFAQFIVAGGYIVWFVLIPMSMAAIYLITDLSLSLRRKKLLPDHIAADIESKAANASPDQLARVLVSHTDLVSRVLMRIIAKSKNTHPDKKYINHLASEALNEQALQLLRKVEWCNIIGNVAPMVGLFGTVFGMIKAFNILGISASQPRPDELAGAISTALITTFWGLLVAIPALAMHGVFRSRIEALVSEAAIEVETLLSQITLPHAPDAEGKGANNIPFAKPVSRGAKQTPRRCPINRTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL0</accession>
    <name>A0A1U9NLL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68821">
        <property type="protein sequence ID" value="AQT68821"/>
        <property type="gene ID" value="STSP2_01997"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01997"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160469" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="505"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="996" mass="108417" checksum="00E05104D673A871" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN3</accession>
    <name>A0A1U9NLN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pta_2</name>
        <name evidence="2" type="ORF">STSP2_01817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01817"/>
    <dbReference type="EnsemblBacteria" id="AQT68648">
        <property type="protein sequence ID" value="AQT68648"/>
        <property type="gene ID" value="STSP2_01817"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01817"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="218"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="39982" checksum="7DAFD6C82950D009" modified="2017-06-07" version="1">MKPIHISATVQDSGKTAVSLGLMQVLRTRGLDPGYCKPVGQHYIRYDDSDIDEDAALVHQYFNMPDKPCHMSPIAIRRGFTRDFINNPNVKPLEDEILRSIAAINKNHPMLIAEGTGHAGVGSCFGLSNARVAQLIGAEVLIVTAGGIGRPMDELALNLALFQKYDVNVMGVVLNKIRADKYEKVTDTVTKGLKLMGTRLLGAMPYESWLESYTVKQLADELKFDVYCGHDCLSNTIENTVIAAMEPEHVVKYIQDNTLIITPGDRIDNMLVSLMLLSKHGPHNGGMILTGGFEPHKEIIPFLQESHIPVLISDEDTFSVSAKLANIGFKIRPEDGPKIDEMHELVEKYVEVDKILGYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU1</accession>
    <name>A0A1U9NLU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA utilization protein GntX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01717"/>
    <dbReference type="EnsemblBacteria" id="AQT68550">
        <property type="protein sequence ID" value="AQT68550"/>
        <property type="gene ID" value="STSP2_01717"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01717"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28637" checksum="E070ACABD7065719" modified="2017-06-07" version="1">MRSFTASLISQTRCFAGSLRKGLSDLLWPGVCCHCGTHLPGNEEFLCKKCWDDFQVCTAGDYCPHCGRDASGYGLLDGQCGNCLDREIMFDSIARVGIYDGLLRNLILKFKFHDGCELAPRLGELAGASLCTAEFAHEIDYFVPVPLFWLRRFGRGYNQSELICKKLPARRAPINNDLVRIRDTQRQWNLTSSKRKKNVAGAFAVRKGHDFAGKRICLVDDIITSGATLNECAAVLKSAGAEQVHALVLAVAAQDSRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX3</accession>
    <name>A0A1U9NLX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68734">
        <property type="protein sequence ID" value="AQT68734"/>
        <property type="gene ID" value="STSP2_01906"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01906"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="159" mass="18771" checksum="23B95D10D47729BC" modified="2017-06-07" version="1">MIRYKTANEQKNSYRSKGEQRIADYLSSQRIRFQYEPPTMVYDLNCKLRVWYPDFRLGGKNGLILEYAGIKNDPDYDRGIAKKKKLYRANGLEALFVYPEDIYRKNWRSNLGDKLMKYRASKDVQSAPAGYHSRQSPCQSYRPPTHSSLRAPVYQNQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ9</accession>
    <name>A0A1U9NLZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cadmium-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cadA</name>
        <name evidence="7" type="ORF">STSP2_02031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02031"/>
    <dbReference type="EnsemblBacteria" id="AQT68855">
        <property type="protein sequence ID" value="AQT68855"/>
        <property type="gene ID" value="STSP2_02031"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02031"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="652" mass="69399" checksum="62BCCDE6BD964254" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM30</accession>
    <name>A0A1U9NM30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase</fullName>
            <ecNumber evidence="2">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nox_2</name>
        <name evidence="2" type="ORF">STSP2_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68969">
        <property type="protein sequence ID" value="AQT68969"/>
        <property type="gene ID" value="STSP2_02146"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02146"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19676" checksum="52FECEB8929B79A9" modified="2017-06-07" version="1">MIELLRNRRSIRKFTDKKVEPDKVELLKEAALRSPSSRNFDPWQFVFVDDPELITKLAESKTHGSNFMLHAPFAVVVLADTTKSDVWVEDCSIASILIQLTAQSLGLGSCWVQIRNRKSPTGRTSDEYVRELLNAPENTAVESVIAIGYPDEHREPKSKDELDFSKIIKNRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM66</accession>
    <name>A0A1U9NM66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar kinase YdjH</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydjH_2</name>
        <name evidence="6" type="ORF">STSP2_01994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01994"/>
    <dbReference type="EnsemblBacteria" id="AQT68818">
        <property type="protein sequence ID" value="AQT68818"/>
        <property type="gene ID" value="STSP2_01994"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01994"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="57"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35718" checksum="6694D905239622A4" modified="2017-06-07" version="1">MSRIEKKITGVGSPIMDLLSHVPDEFVSTHAGEKGGMALVDHDAMEALLSRLDEFPKLAAGGSAANTIFALARLETPCGFVGKLGDDAQAKEYLQHFEKFGGDTSGFKFCTKDATARCLSLVTPDYERTMCTCLGAAANLAPDEISISDFEGYSHVHLEGYLLFNQDLIKAILKHAKDAGCTVSLDLGSFQIVESFKDLVTELLDKYVDIVFANEDEAEAFSGSKDPEESLKLLGKYCDIAVVKLGAEGSFIQNTEGKVKVVANPVESVVDTTGAGDYWAAGFLCGYLRGYPMNVCGEMGSILGAEVVQQLGAELPDDRWSAVAEQFNNIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM70</accession>
    <name>A0A1U9NM70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="4">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabF_1</name>
        <name evidence="4" type="ORF">STSP2_02010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02010"/>
    <dbReference type="EnsemblBacteria" id="AQT68834">
        <property type="protein sequence ID" value="AQT68834"/>
        <property type="gene ID" value="STSP2_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02010"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="45781" checksum="F1CDEC769F96F5BA" modified="2017-06-07" version="1">MAERVVITGMGLVSPMGHDVETVWQGLLTGKNGMNETTLFDASTFPTKFGAEVKDFDLAKVLKKPELHKDALRGSAFVLGACAEACKQAGIETETDAASDGVDRENMGIYLGAGEGAIDSGPFFKAIADAWNDEGREMDWEKWAQTAFGGMTAMRELEQEPNMPAGHLAVLTGARGPVRSCLTACAASTQAVGEAAVMVRSGQADIMIAGGAHSMIHPLGVSGFSRLTALSTRNDSPETASRPFSASRDGFVLGEGGAIVILESLSSAKKRGAKILAEITGFGSSADAFRVTDMHDEARGAVQALKAAMADAGVGPEDIDYICTHGTSTSENDAVETKAVKKAFGEQAYNVPLSSPKSMMGHLIGATGCAELIVCVQAMRDQTIPPTANLNDPDPELDLDYVPNEPRKAKLETVINESFGFGGQNNVIVLKKFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB2</accession>
    <name>A0A1U9NMB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68730">
        <property type="protein sequence ID" value="AQT68730"/>
        <property type="gene ID" value="STSP2_01902"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01902"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20654" checksum="4B5A41F42D07BF92" modified="2017-06-07" version="1">MKTQQVVYQQVPLRATVQPVRAERYGTVEGLDSYELADPAELERMAYLRFFEPVLTLPHPEKDRPFMPDIAGGAFDSWDFERMFPGMREYAYRIRTLNWLKSKLSDRLNLLAILKEKLTRPQRARGISAARGAADISEIADPDTRMFASEYRRSLQLRNRIQRFRSTGILNQTPRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD2</accession>
    <name>A0A1U9NMD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apu_8</name>
        <name evidence="3" type="ORF">STSP2_01922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68750">
        <property type="protein sequence ID" value="AQT68750"/>
        <property type="gene ID" value="STSP2_01922"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01922"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012753015" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="894"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1090" mass="115399" checksum="FE58CF339D376E7D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME6</accession>
    <name>A0A1U9NME6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69091">
        <property type="protein sequence ID" value="AQT69091"/>
        <property type="gene ID" value="STSP2_02278"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02278"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010725564" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="22789" checksum="0E4A6A535AFF0861" modified="2017-06-07" version="1" precursor="true">MKKLLGIVLVLVMAGCLNAAVINIVNGDFESGDIWATNSGTAPEGWVASGSYVSGQRVPGLPGMTACWQDRDGLRYYEQQITSSDAGDVDAGTYSLYEVTFDYGYRRDSSTNGPINLLVSLRDTTEDVELASENIIIPDPGRGTNFLTTAVVVLYIEGTAGNGLALRFTENDPGSRGWTATTMIDNISLITKGDVAFSPSPADGLIRIVINSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF4</accession>
    <name>A0A1U9NMF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68770">
        <property type="protein sequence ID" value="AQT68770"/>
        <property type="gene ID" value="STSP2_01942"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01942"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025399">
        <property type="entry name" value="DUF4372"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14294">
        <property type="entry name" value="DUF4372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4372" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="382" mass="43773" checksum="B74FAC0801474604" modified="2017-06-07" version="1">MIKVASVFAQVLSLVDHPKFSLSVAKLGAEKGAKGFRCWEQFVCMLFCHLAGANSLREICGGLASSAGRMVHLGIKRMPKRSTLSYANNHRPWQVFESTFYELLGQADLLAAKQRRRFRFKNPLVSIDSATIDLCLSMFDWAKFRRAKGAVKLHLMLNHQGHLPGWALVTDGKMADVKVAQKLEFAPETLVAMDRGYVDYDMFERWTARRVWFVTRAKKNMKYLFVQYNEVPERSNLIADDIIELVDKPGLRLRRVVVWDKENLRPIVLLTNHMKFAASTIAAIYKERWQIELFFKAIKQNLKIKTFVGTSENAVKIQIWTALISILLLKILQMRSRIGWSLSNLAAMLRFNLLSYTLIPAIQHCLAASFLRQSPVVNHLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH4</accession>
    <name>A0A1U9NMH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular exo-alpha-(1-&gt;5)-L-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02308"/>
    <dbReference type="EnsemblBacteria" id="AQT69121">
        <property type="protein sequence ID" value="AQT69121"/>
        <property type="gene ID" value="STSP2_02308"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02308"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143326" evidence="4">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="40518" checksum="6356B5990199FB32" modified="2017-06-07" version="1" precursor="true">MKTVSLIIILVVALVLSVTGVAQSTESADTFTNPLLKSGPDPWTVYHNGQYYYIKSERNRLVLLKTPDITNLARAERKVIWRAPAGTSHSKNLWAPEIHFIRGAWYVYYAADDGNNHNHRLYVLQNKSKDPFMGSFGMKARIKTDPADNWAIDGTVFEHKGQLYLMWSGWKVPKVHIETQRIYIARMSNPWTVSSDRVQLSEPEYDWERVWKSPPGNGPSAPVYVNEGPQMLKHGSKMHVVYSCSGCWTPDYALGMLTADIDSDPMDPNSWTKSSEPVFQQCPENGVYGTGHNCFFKSPDGKEDWILYHANDKPADGCGRKRSPRAQKIEWSDNDMPVFGIPLPTSTVMEKPSGIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI6</accession>
    <name>A0A1U9NMI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AQT69123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_02310"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="166" mass="19242" checksum="733E101DC24AD4F6" modified="2017-06-07" version="1">MNKTGHKRSGAGKWARRGTRPTAWRQTQYEYLYVLGAACPQTGQTVGLLAPCLNTDSVNAFFREFEKEVDPAVHVFMIWDQAGFHTSKKVKVPENVTIIPLPPYSPQLNPIETLWLYLRQHHWSNRVYDGYDHLRRAANQAWHKVCLNTRKIKSICRAKYIENAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM9</accession>
    <name>A0A1U9NMM9_9BACT</name>
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        <submittedName>
            <fullName evidence="6">PQQ-dependent catabolism-associated beta-propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_02360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02360"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="397"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="513"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="613" mass="66925" checksum="C074B1FB369841E6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU1</accession>
    <name>A0A1U9NMU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02408"/>
    <dbReference type="EnsemblBacteria" id="AQT69219">
        <property type="protein sequence ID" value="AQT69219"/>
        <property type="gene ID" value="STSP2_02408"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02408"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
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    </dbReference>
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        <property type="entry name" value="LarE"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="NAD_synthase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30532" checksum="53E98DC19B5F3907" modified="2017-06-07" version="1">MGIDKKYSILLDNIRALDRVLVAYSGGVDSTFLLRAAVEAVGPDDVLACIGVSPSLPEAQHKQALDMAASMGARVREVTAHELNDPDYKANKADRCFHCKSHLYKLLWGVAKDEGFEHVACGSNLDDMDDYRPGNRAAKAFNVHAPLMEAELTKPEIRELSKRFGLPTAEMPASPCLASRISYGMQITAEKLGKVERAEEFLHELGFAECRVRHHGDLARIEVPGNEVSKIASDEMREKIAAKLKEIGFKFVSVDLSGFKSGSLNVMLSEEEKRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY0</accession>
    <name>A0A1U9NMY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAC2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02137"/>
    <dbReference type="EnsemblBacteria" id="AQT68960">
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        <property type="gene ID" value="STSP2_02137"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02137"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="32855" checksum="5A0FE68CBBDD03AD" modified="2017-06-07" version="1">MSAQMLNILEKPNMKNPTLLLGFSGWMNGGEVSTGTVQWLIEDSRAREIAEINPEGFYIYNFPGTMETTTLFRPHTRIVDGVVAEYQTPENVFYYDDSKDLVLFSGKEPNLNWEGFADCIFEFCEVFGIEQIVFIGSVAGLVPHTRDPSMFFSVSDENLRSELKDQGFSMSEYEGPASFTTYLAAECPARNKKMVNVVAAVPAYVQGENPKCIEAVLRNLTRVMDVKINLHDLRFLSDEFEKRLTEAVKEVPELSENIGKLEQMYDKEIIDHEMGDLKRWLENRGVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY8</accession>
    <name>A0A1U9NMY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69104">
        <property type="protein sequence ID" value="AQT69104"/>
        <property type="gene ID" value="STSP2_02291"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02291"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="9163" checksum="5C6F31F1389F5417" modified="2017-06-07" version="1">MQFIIGHTEKFVAFLAFSPKPHILLAAPDITEEITQNLESKHNKLKPVTLALFRKEHLKIMHGQIAYGSKLRIEEILNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN28</accession>
    <name>A0A1U9NN28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG nucleotide pyrophosphohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69313">
        <property type="protein sequence ID" value="AQT69313"/>
        <property type="gene ID" value="STSP2_02502"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02502"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011411">
        <property type="entry name" value="MazG-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036521">
        <property type="entry name" value="UCP036521_pph"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10272" checksum="98A5BD187E43FA27" modified="2017-06-07" version="1">MEIKQFQEWISNKYEQRDLERGTPATFMWFVEEVGELATALAEDDFENKQEEFADVLAWLCTLANINGIDLDKACTKKYVENDIEGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN90</accession>
    <name>A0A1U9NN90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative teichuronic acid biosynthesis glycosyltransferase TuaG</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuaG</name>
        <name evidence="2" type="ORF">STSP2_02456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02456"/>
    <dbReference type="EnsemblBacteria" id="AQT69267">
        <property type="protein sequence ID" value="AQT69267"/>
        <property type="gene ID" value="STSP2_02456"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02456"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27905" checksum="1AA7C5541749945E" modified="2017-06-07" version="1">MTNPLSKPYLSIILPAYNEGRKVAVDVERASGFLDRENLTGEIIVVDDGSTDDTASVAKQASISSDIALNVKRYDQNRGKGYAIRTGVLNSAGRYVMFADCGCCVPYHHAKKGLDLISSDGCAIAHASRRDQQSDIQHDQPLQRKLFSKAFRWTIINFMGVPAHLTDTQCGFKVYRGDVARQLFSQCVVDGFMFDVEVILRAHRAGYKIGEFPIEWTCDRDSRLTVRRNALEILRELWQIRQALKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG3</accession>
    <name>A0A1U9NNG3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02633"/>
    <dbReference type="EnsemblBacteria" id="AQT69443">
        <property type="protein sequence ID" value="AQT69443"/>
        <property type="gene ID" value="STSP2_02633"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02633"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_14" evidence="1">
        <location>
            <begin position="274"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="44150" checksum="6E750951B61BE40A" modified="2017-06-07" version="1">MLKVCPVCRSKEIDEIVYISAVPALANVLWSDQERAVSAKKGDICLVICRNCSFIFNSAYDPDLVDYDCCYENSLHCSNTFNGYCERLASDLSQRLHLKDKTIIEIGCGQGQFLSMLQHAGDNLAIGFDPSYRGAEPEEHDKTKIYTCIFPPKHPLEQEPDFLCCRHVLEHIFEPEAFVEEVTAAAKPRCKLYFEVPNANYMLRLPGIWDLLYEHFAYYTTTALKYLFLSAGCENIQVTERFYDQYLGLEAYTGKKRLSTNCQPQTHQIVTSAQKFGKAYKEKVQEWAKYLDSLVSKGEKVIIWGAGAKGIMFLNFLGMDYRTVPFITDINPAKHGCFLTGSGQMVIPPEELTSYRPDKVIIMNPAYKNEIEADLQRMDLHKAQILIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK7</accession>
    <name>A0A1U9NNK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69532">
        <property type="protein sequence ID" value="AQT69532"/>
        <property type="gene ID" value="STSP2_02723"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02723"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9551" checksum="38DCC34D3EEB896F" modified="2017-06-07" version="1">MNPQVIFILKLILILTAGPLFIIAAILHAYARIKLKPPPEEMDAYYFEVEHMNPDLARYRKWTRSTYTAAIIAMAMLFLGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL1</accession>
    <name>A0A1U9NNL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02670"/>
    <dbReference type="EnsemblBacteria" id="AQT69479">
        <property type="protein sequence ID" value="AQT69479"/>
        <property type="gene ID" value="STSP2_02670"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02670"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="19920" checksum="D04B0D9355E2D17F" modified="2017-06-07" version="1">MDIFEFAMEKEKMSREKYLDMAEKSKSVGVKHILQMLADEEEKHYHTVERMKQETPEGVTKTDVLADAKKVFEKMQGAREEIKFEDDEKEVYHQAKKIEEEARDYYLQKEKEADDEVEKKIFHRLAEEEQKHWFVIDNICDFVEKPEYYLENAEFVHLDNYVPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP8</accession>
    <name>A0A1U9NNP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase 1, rSAM/selenodomain-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02429"/>
    <dbReference type="EnsemblBacteria" id="AQT69240">
        <property type="protein sequence ID" value="AQT69240"/>
        <property type="gene ID" value="STSP2_02429"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02429"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25998" checksum="0EEF6B3EE7CD423B" modified="2017-06-07" version="1">MSTHKGNCTAIFVKYPEPGKVKTRLGNQIGHDQAAELYGNFVLDMIDVYRQADCHLRIFVDPSSDRELYREWLGDDLTYAAQTGKGLGERMLNAFEEMFAEGFSKAILTGSDIPDLTVQTINDAFTALSENDVVLGPSSDGGYYLIGFREASFVKEVFKGISWSTDSVLDETLSKFTEHALSEHILDLWHDIDTKEDLIELISRNKDTAFMDSRTVRYLHQHTDITFAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ6</accession>
    <name>A0A1U9NNQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69146">
        <property type="protein sequence ID" value="AQT69146"/>
        <property type="gene ID" value="STSP2_02333"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02333"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9377" checksum="D061A4241DC5BBFB" modified="2017-06-07" version="1">MDVDQILEDLLIVLESADVSLKREPMGGGGGGLCRIKDRLVFYVDTDAPALLNAENVAVAAADVTDLDLIYLRPEVRDFVEKTVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY1</accession>
    <name>A0A1U9NNY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase EpsJ</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsJ_1</name>
        <name evidence="2" type="ORF">STSP2_02817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02817"/>
    <dbReference type="EnsemblBacteria" id="AQT69623">
        <property type="protein sequence ID" value="AQT69623"/>
        <property type="gene ID" value="STSP2_02817"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02817"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="317" mass="36326" checksum="B1E297951157FE4D" modified="2017-06-07" version="1">MKIAAVIPAYNVGKYIGRTIESVLAQTRPADEIIVVDDGSTDDTAEKIESFGDKVKLIRQQNAGASVARNTGIEAATSEWIALLDGDDEWLPHHLQNQEHILKNNPDLHWSTANFKFCYCADKTQKNQSDPDAMRTALSDKQYLEEYFQAFINHTTGCTDTIIVKRQILFEAGLFTPDQPMANDLDMWWRIAYLCPRIGCSPEPAAIYHLHVANSITKVHKSPSILADLIEKHIQIAKDHNAYHRFRPCAEHLLRFWIHKYFFDERISEIRPLTDRFPHILPLGYHTILRILTISPRTTTALMPTLQMINRLLRLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY9</accession>
    <name>A0A1U9NNY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69631">
        <property type="protein sequence ID" value="AQT69631"/>
        <property type="gene ID" value="STSP2_02825"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02825"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="706" mass="78805" checksum="F9BFAF47DDFF0586" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP14</accession>
    <name>A0A1U9NP14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69585">
        <property type="protein sequence ID" value="AQT69585"/>
        <property type="gene ID" value="STSP2_02778"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02778"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21248" checksum="996F66FAC956AE25" modified="2017-06-07" version="1">MCKSIRYSAAQNRQLIRLNRPAFTLVELAVTSVLSTIVVLSAMVMMVDQTRGWHDIYSKVHGDVAVDSTFSRRVFERTCRKATERRAEINEDGNELIVFYFSESAPNDASWPDRYARFHISNDELMLVEGDLTAGEWIRQAADSHRVLARNVSELNFAARNNAIQMNLKLDDGENFSSMVCSASRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP60</accession>
    <name>A0A1U9NP60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">STSP2_02715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02715"/>
    <dbReference type="EnsemblBacteria" id="AQT69524">
        <property type="protein sequence ID" value="AQT69524"/>
        <property type="gene ID" value="STSP2_02715"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02715"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
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            <begin position="292"/>
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            <begin position="99"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="328" mass="35374" checksum="5F99E5BDC14801AD" modified="2017-06-07" version="1">MPQSSKKPNSTEHNSPVEFSAPLMMSPGEDIRGFLTFHGVKFLLFLITCASVLAVLLIFFFVCREAIPFLTQHDVAEFFTSTDWYPEADTPQFGGLALITGSIYATLIAMVIAVPIGLLAAIFLSDIAPFKLREYIKPIIELLAAIPSVAYGFFAILIFAPMLQKQFGFTTGANALNAGIILGIMALPTIISVAEDSLSAVGREIREASYGLGANRFETIIKVVMPAAHSGIIAGIILGVMRAIGETMVVLMASGNASQIPTPWYDIGQSIRTMTATIAGEMGETAKGSDHYYSLFAIGLILLVFTLLLNLISEHFMARIRNRAGGNK</sequence>
</entry>
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    <accession>A0A1U9NPA7</accession>
    <name>A0A1U9NPA7_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Putative bile acid beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH116_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydr_116N" evidence="2">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DUF608" evidence="1">
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            <begin position="653"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117995" checksum="997D0779833377C5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB3</accession>
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        <name evidence="3" type="ORF">STSP2_02958</name>
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    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="4" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="390"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="629"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="717" mass="78545" checksum="85093FB99B6177CC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE2</accession>
    <name>A0A1U9NPE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage 0 sporulation protein KA</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">oppA_1</name>
        <name evidence="3" type="ORF">STSP2_02565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    <dbReference type="EnsemblBacteria" id="AQT69376">
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        <property type="gene ID" value="STSP2_02565"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02565"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010738398" evidence="1">
        <location>
            <begin position="26"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="504"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="593" mass="67603" checksum="78CF307E52906E2C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE5</accession>
    <name>A0A1U9NPE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_14</name>
        <name evidence="2" type="ORF">STSP2_02976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02976"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="30204" checksum="A9DC51AE62085B36" modified="2017-06-07" version="1">MQVKLYKGFTLIELLVVISIIGALTAMMFPVLGMCKNSARMAVCRSNLRQLVIANKGYAEDNDGYSVPGGLNITTENLQRWYGSRESKYDEFDPEKGLLTPYLESAQLECPQKVRYMEVEPVHEKYEGANGGYGYNFVYLGSRIWKSGYGNPDSSNSTQLGRVKRPGQTLIFTDTAMVSREENGEGLMRYAFIEPYMFVIYGEATPTWVPDPSMHFRHGGRVCAAWVDGHVDVRKSSGYDGENYDGCRPGRYDLGWFEPLDNSLIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT5</accession>
    <name>A0A1U9NPT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator YesS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yesS</name>
        <name evidence="3" type="ORF">STSP2_02814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02814"/>
    <dbReference type="EnsemblBacteria" id="AQT69620">
        <property type="protein sequence ID" value="AQT69620"/>
        <property type="gene ID" value="STSP2_02814"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02814"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="323"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="49604" checksum="F0723C4A321674F9" modified="2017-06-07" version="1">MSKSQKLKDMVPKHDFLKVEQAFRKHVGLGLETTDTDGYEVRQLCSSDCHPEFCRQIRESRPGSSRCREDRRRSLTMAFETGQPYISICHAGLVLVCVPIMEKDTPLGGLFFAKCLSEPVNEVITEDIIKRLRGLRPSKIRMALTLEKLPVCSARQIHEAAEFLFILFYEITGLDPRVVKWRREKADQQAQISEYIQESKKVGPSTHYPYKSERKLISKVKIGDRTGAKEILNSMLAEIIIQNPGQLSVLKARLVELLSILSRAAVEGGVDINDMLKDNLVYIEKIMNIDTQDELCAWAGKALDEFTDKVYANQDDQKMTQIKPAIEHMKMHFDRTLSLAEIAKAAHLSVSRLAHIFKEQMGMTIVDYLTSLRIDYAKRLLLGTDESCTMICYKIGYNNQSYFTRTFKTVTGMTPRQFREKNKRPPNPEAKGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW2</accession>
    <name>A0A1U9NPW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02961"/>
    <dbReference type="EnsemblBacteria" id="AQT69764">
        <property type="protein sequence ID" value="AQT69764"/>
        <property type="gene ID" value="STSP2_02961"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02961"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="175"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="504" mass="56221" checksum="A73FADE4CFA92C64" modified="2017-06-07" version="1">MNEHIENYRIISKLVLLAVNGSLNEQQALKLNNLIINDSQARDYYLECIATQVALQNIECISDQDESELLDVELWRSLAYTEMTAPEVVIPKSNEPVPTHTSQVEKRPNKINKITLYTAIISSVTLFFLMVTVLLTPKSEPVAVFTNSVDAQWGEGPDVLVPGDKLRPGSLRLTKGVAEITFYDGSVVTIEGPAKFNLEAENEMFMQFGKLWAKCEYNAGFMVRSPGATVVDYGTEFGILVDSRGNTNAYVAKGEIDLRVGSDVKVYKKSQRLIAGKAACVQDQSISKVDSWDKPFVRSVNEIEQARKLFGQNLIVNGDFEQDEGMVSAAQLHENMHISGWEDDSQAIAVNYKLFETNEFRVPDLSEEVLPPNRGNNFFHSLHNSTISQNIDISKLFYYVDHGAVSYDLSGWLGGWEDQDNPVELKLTFLDSNGNPLGKSQIGPVEPTERNNQTGFVRREKTGTLPFNCRTILVELQGRQLSSDDSDAADSYADNLSLVLNVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ09</accession>
    <name>A0A1U9NQ09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump periplasmic linker BepF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepF</name>
        <name evidence="6" type="ORF">STSP2_03225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70023">
        <property type="protein sequence ID" value="AQT70023"/>
        <property type="gene ID" value="STSP2_03225"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03225"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="88"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="43985" checksum="0E664496B2F04B42" modified="2017-06-07" version="1">MSDKKKDTDKKHSLAKGLGTFVLFAVLIAVGWTLNALMPGGKPGGPPAGPGAQMPGKGGPPAVKVQTVSEEMIYPSSEYIGHVKPVQTVDLRAQVDGYIEKVHFEEGSVVEQGQLLFTIRQDRYKARIASHEAMLAQAQANLVRAEKYLARLRNAEKRSIVQAEFDKAESDVMQLKAQIKQHQAQIQLAEIDLDYTEIHAPIDGKIGQAFATQGNYVSPASGTLAQIVQLDPIRVGFSMPDRDYLTLLEKIQQDDANVTSRIQLPNGSDYPATGVYDFTDNTMDRSTGTIAVFSKFKNDRSLLIPNSYVNVSLQTGDGKKMPVISQRALVQESQGTFVYVLKDDNTLEKRPVKLAQALKSDQAISEGLSVGEKVVVRGLQKVKPGTKVTLLDKQSQEYTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ34</accession>
    <name>A0A1U9NQ34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69935">
        <property type="protein sequence ID" value="AQT69935"/>
        <property type="gene ID" value="STSP2_03135"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03135"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5693" checksum="9FA1D70041951796" modified="2017-06-07" version="1">MGSRRRITKDLMKAKGVQTKHKETRYDERGRPYSVLVSSIASTGLRVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ44</accession>
    <name>A0A1U9NQ44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Free methionine-R-sulfoxide reductase</fullName>
            <ecNumber evidence="1">1.8.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrC</name>
        <name evidence="1" type="ORF">STSP2_03107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.4.14" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03107"/>
    <dbReference type="EnsemblBacteria" id="AQT69907">
        <property type="protein sequence ID" value="AQT69907"/>
        <property type="gene ID" value="STSP2_03107"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03107"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17019" checksum="D0FB58DB984BCE33" modified="2017-06-07" version="1">MNSDAKSRRYERIHSQLSDLLSQTPDTTARMATTAALLHHKFKSFFWTGFYRLIDGQLTVGPYQGPLACQILEKDKGVCWAGVNSREPVVVPNVHEFPGHIACDSRSKSEIVVPCKDKNGNIYAVLDIDSTDFDTFDETDAAGLENITALLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ82</accession>
    <name>A0A1U9NQ82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03078"/>
    <dbReference type="EnsemblBacteria" id="AQT69878">
        <property type="protein sequence ID" value="AQT69878"/>
        <property type="gene ID" value="STSP2_03078"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03078"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775671" evidence="5">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="47324" checksum="030D3CCDA1B435DB" modified="2017-06-07" version="1" precursor="true">MKKSYEKKCLLILVVVSLASLALAGEKTVPGYLEDHAKLYAENPRQANFKWFDQARMGLFIHWGVWGPYEAEWQMFYSRIPLEEYKKTAARFTGKDFDAEEIVKFARASGMNYITFVAKHHDGFCLWDSAYTDWDSMDYQAKRDFLGELAQACHAEDMPLFIYYSIGIDWTHPYFMPSNLYGCARPHYKAKPDYFRYAKEEDFEIYRQFCKNQLSELCEKYGPVAGFWFDTLGGVLANPEMFKMQEFYDLIHEHQPHALIGFKTGATGTEDFLIGERHLGSIAGAYPGNSPENRRIRKLADEAWSKNYGKKAEICVTSTGSWAWRKNAKCWSPAKLWRMLESASDNNANLLLNTGLDIDGGIPDDARKNFQALGDRIRKEGYPKLNKTTYLQKRKTEEVVDDNEKVKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD1</accession>
    <name>A0A1U9NQD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69944">
        <property type="protein sequence ID" value="AQT69944"/>
        <property type="gene ID" value="STSP2_03144"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03144"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="486" mass="52436" checksum="9D547D76901AA55F" modified="2017-06-07" version="1">MAKRKKTTKNSDNKPETQVSGRSAKRGKTAASGGAGKTACKGSKRTQRVVKSGPKKADGGRSVKSAGSSKSQSSSGGDRGVVVAEQVADISSAGAGDHLRGGTKKAAGKSSRSGKAAAAKPASKSGSKTKASKRKGKSGSSAAPAKASTRGKSKKSVKKKVSKKKLPVAVAVIRDLAFHSDSFTDAASKFVELAAKRRCKRDLQAILDEHQDLQDAWQRGRLLKNIGELAATGVNIGEAEHHLKLATGELKAMMAEQSEVADIWNQSRLKLTIDLKQAVVANALQGKVGALKQVETLLRREIARPSADFHSLSIADMCEILGITRQTLHDWYKERGCPRNSDGSYDLCQFFEWYERHIIETRGTAGKSAAPKLDPLKAAKAQKMEKELAELEGRLLDRQQVVMGLMARHQKFVNESGRGLHDLAMRCHKRDSEDILKLLNEHMTDLRQKMCEVPAEMRLPSDAENKLIEVMSMLAPAEGDGGKGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE0</accession>
    <name>A0A1U9NQE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">STSP2_03333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03333"/>
    <dbReference type="EnsemblBacteria" id="AQT70129">
        <property type="protein sequence ID" value="AQT70129"/>
        <property type="gene ID" value="STSP2_03333"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03333"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="253"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="316"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT70129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="390" mass="43734" checksum="F74EF27C5E43D6CC" modified="2017-06-07" version="1">MFGRKIRLFTLMGFKVGIDLTWFILAILITWSLAEGLFPYLYEDLSTRAYWWMGVAGALGLFVSIVFHEFCHSIVARRYGLPMKGITLFIFGGVAEMDEEPPSPKAEFMMAIFGPISSIFLGVVLVGIAFVGESLNWILPVTGVIEYLAWLNFILAIFNLIPAFPLDGGRVLRSILWHYKHDLRKATKTAANFGSAFGTVLIILGVIVFIGGNFIGGIWYFLIGMFIKNASRMSYQHVLVRKTLSGEPISRFMNTEPVTVPADDTVQDVIEKYFYKYHYKMFPVMRGEDLVGCITSRKIKELSSKDRQTSKVGDLAISCSEENTIGPETDSMDALSLMNKTGNSRLLVVEDDRLKGILTLKDLLEFLALKVDLEEDENLKITPESAGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE4</accession>
    <name>A0A1U9NQE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-specific methyltransferase EgtD</fullName>
            <ecNumber evidence="4">2.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">egtD</name>
        <name evidence="4" type="ORF">STSP2_03355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03355"/>
    <dbReference type="EnsemblBacteria" id="AQT70151">
        <property type="protein sequence ID" value="AQT70151"/>
        <property type="gene ID" value="STSP2_03355"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03355"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="32"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="38308" checksum="45990A262C4DDBC2" modified="2017-06-07" version="1">MATQTITKRTGTKVSITNYLTETDSNELIELILSDLNRTPRRISSRFFYDEYGSELFEKITTLPEYYLTRIEKRLLQNVAQSIAPTCKEIDIVELGSGDCSKISILLNAFNARHRKTIRYVPVDVSESAIKKSADILSHQFPDLQIEGIAADFLTQLHVIPQTKNHLFCFFGSTLGNLTPEHAFQFFTQLGNVMMPGDSLLLGLDRVKPQHILEKAYNDTQQVTSAFNKNILNVVNQIIGSDFNPQTFQHVAFYNEQHNRVEMHLKANEPMTINMPFAKRNLVLRSNEMLHTENSYKFDDQRIDELVSSSDLKITNFYSDRQDWFSVIWLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE9</accession>
    <name>A0A1U9NQE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator PleD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02932"/>
    <dbReference type="EnsemblBacteria" id="AQT69736">
        <property type="protein sequence ID" value="AQT69736"/>
        <property type="gene ID" value="STSP2_02932"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02932"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="71"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21131" checksum="2E4ACF8CFB67C8D1" modified="2017-06-07" version="1">MNKKKDVLTTGQVAQICNVAPRTVTKWFDSGQLKGYRIPGSRDRRIPTGELLRFMKAHDMPTDALEIGKMRILIIDSDKDTAEDLAAGLETKRNYEVEIALNSFDAGIIAQRTTPHVILLNLMAQNIDADQICSYVRTNDELNSTRILAVAEGSGEKEEQALINKGYDGVISNAGDFTATIAMIQNASTVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG3</accession>
    <name>A0A1U9NQG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltaA</name>
        <name evidence="6" type="ORF">STSP2_03378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.49" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03378"/>
    <dbReference type="EnsemblBacteria" id="AQT70173">
        <property type="protein sequence ID" value="AQT70173"/>
        <property type="gene ID" value="STSP2_03378"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03378"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="37125" checksum="F3220C59A66A6B3E" modified="2017-06-07" version="1">MGVIDLRSDTVTQPTVRMREAMRDASVGDDVLGDDPTVQKLERLAVDKLGTEAAIFVPSGTMGNLVSAMVHCPRGSEVILGDKAHMFVYEAGGMSAAGGIQPHTIPNQADGTLRLEDIEHAVRAENVHFPRTRLICLENTQNKCGGRVLRPEYCWEVREIADKHALKMHLDGARVYNAAVALGIDVRELAEPFDSVSVCLSKGLSAPVGSVVCGRKDFVYEARRARKLLGGGMRQAGVLAAAGIVALEDMVDRLSEDHANAKELARGLAETGMFSLDAEAVETNIVYFDLAMDKIGADELVAKMAERGVLFLALGPGRFRMVTHCGISAGDVETALDVLGGVAGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ1</accession>
    <name>A0A1U9NQJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">frr</name>
        <name evidence="6" type="ORF">STSP2_03384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03384"/>
    <dbReference type="EnsemblBacteria" id="AQT70179">
        <property type="protein sequence ID" value="AQT70179"/>
        <property type="gene ID" value="STSP2_03384"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03384"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20879" checksum="23206157500D0460" modified="2017-06-07" version="1">MPVQNILAEHEDSMKKSIDFLHTELKGVRTGRASTGLVEHVRVDYYGSPTPLNQLATISTPDATSIVIKPFDPGSLKDIEKAIKVSDLGLPPIADGKVVRLSIPPLSGERREQLVQQVKQMGEQTKISIRNIRRDANKQLDDEEKSKDITEDDRDRGKKEVDEITKKYTEEVDSVVKAKSEEIMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ2</accession>
    <name>A0A1U9NQQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein containing a PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70239">
        <property type="protein sequence ID" value="AQT70239"/>
        <property type="gene ID" value="STSP2_03445"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03445"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17757" checksum="4E7E375589BCE681" modified="2017-06-07" version="1">MSYIIDGYNLLRYAQQHDDYEALEDASLCHVLNLFLKRVNERAQIVFDGIGPPDKSGLRSRGNIEVYFSGRGIEADDIIEGKVMASTDPANLVIISSDRQIRTVARQRKATAITSDVFWMILCHELDKKKGKPEPREKRQGINNSETDQWLDEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY4</accession>
    <name>A0A1U9NQY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03232"/>
    <dbReference type="EnsemblBacteria" id="AQT70030">
        <property type="protein sequence ID" value="AQT70030"/>
        <property type="gene ID" value="STSP2_03232"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03232"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323967" description="SASA domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="295"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="578" mass="62103" checksum="478D9D54869F93F2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR17</accession>
    <name>A0A1U9NR17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70168">
        <property type="protein sequence ID" value="AQT70168"/>
        <property type="gene ID" value="STSP2_03373"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03373"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25927" checksum="92E65DF1129D4557" modified="2017-06-07" version="1">MLAEYDGSDNFKRYRKAFLKLLLNLRPEIFSAGKACKIGNSRNYGRFCTTQPDGKRAAAKQNEFQNDFPVYGNYIDEPLMTSDGSTDLYYAHDHLYSTAALIDTAGNVVERCEYNAYGKATVYNADYTQSWAVSQKENPYLYTGRRLDILDGGSLKLQYSRHRYYDPQTGRFLQKDPLGIVPDALPRGQVMPKLQLTDGANFYSYVNANPAYCSDPFGLLRYSSVVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR68</accession>
    <name>A0A1U9NR68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03483"/>
    <dbReference type="EnsemblBacteria" id="AQT70277">
        <property type="protein sequence ID" value="AQT70277"/>
        <property type="gene ID" value="STSP2_03483"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03483"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="226"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="601" mass="70052" checksum="D6F75E0E0986DB27" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRJ5</accession>
    <name>A0A1U9NRJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="8">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kamA_2</name>
        <name evidence="8" type="ORF">STSP2_03534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03534"/>
    <dbReference type="EnsemblBacteria" id="AQT70328">
        <property type="protein sequence ID" value="AQT70328"/>
        <property type="gene ID" value="STSP2_03534"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03534"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="86"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="43714" checksum="603DE531F9B651D5" modified="2017-06-07" version="1">MDRKVKYYNDLSRIPQLSDAEKADLQAVADKFVFRTNSYYLSLIDWDDPADPIRRMIIPQNSELEQWGDLDPSNEAAYKIMPGLEHKYDSTALILVSEACDSICRYCFRKRVFMDASDDRIDNVDEMLDYIRTHTEISNVLLTGGDPLTLSTEKLEMIIAELRKIEHIRIIRIGSKLPVFNPYRIIDDPSLAKMVEKYSLPDRKIYVMTHFMHPNELTETAVKGLNILQNAGAIVNNQCPVLRGVNDNPAVLAELWRELSFAGVIPYYAFQCRPALGNRDFTVPIEEAYDIVEQAKARVSGLAKRVRFAMSHSTGKIEIAAKTRDYILFKYHRAQDNTDSSRILVCKRNPNACWLDDYEEVVESFRPADKCWSLKPEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRV8</accession>
    <name>A0A1U9NRV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70256">
        <property type="protein sequence ID" value="AQT70256"/>
        <property type="gene ID" value="STSP2_03462"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03462"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3637" checksum="39CF91875BAF6DCB" modified="2017-06-07" version="1">MWVNCAKKEALGGSQGLEMVYKLIFSFNWQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS03</accession>
    <name>A0A1U9NS03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70296">
        <property type="protein sequence ID" value="AQT70296"/>
        <property type="gene ID" value="STSP2_03502"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03502"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12837" checksum="942FB950F3FC06B3" modified="2017-06-07" version="1">MQIYSYSFGRMVVDGKEYHDDLVILPGKIVSGWWRIEGHVLNCEDLEEILEGDIDELVVGQGESCSMKINGGCRRMIEGRGIKLITANTKRAAEMFNDKVRHHVKVAGAFHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG64</accession>
    <name>A0A1U9NG64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgG_1</name>
        <name evidence="8" type="ORF">STSP2_00059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00059"/>
    <dbReference type="EnsemblBacteria" id="AQT66921">
        <property type="protein sequence ID" value="AQT66921"/>
        <property type="gene ID" value="STSP2_00059"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00059"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="181"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="27253" checksum="D31CDC8ABEF73C44" modified="2017-06-07" version="1">MLRAFSTAATGMTAQQQMVDTIANNLANINTNGFKRRQAMFEDLLYVKMKEAGREVSAGVTAPSGIEIGSGTRLSAVTKVFSPGERVETGRALDMAINGDGFFQVTLPNGDLRYTRDGSFQTNAQGQIVNSNGLALDPPVTIPDNATGISVGVDGTVTVTTDKGTQQVGNIQLVRFPNAEGLTAEGGNLFAETESSGAPLTGTAGEDGFGGIQAGSLEKSNVQMVSELVDLITAQRAYEINSRAIKAGDSMLQTANQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGD1</accession>
    <name>A0A1U9NGD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66989">
        <property type="protein sequence ID" value="AQT66989"/>
        <property type="gene ID" value="STSP2_00127"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00127"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24711" checksum="40FD9B0E2B4D2AB4" modified="2017-06-07" version="1">MLWQYEFIVRGKKRSDEGLPDFNQPDLGFERTVRAVAKTEREAHNIIKPLFTDRKEIQPPCTYTLTAQQEIAAADESHERYTNQGPFIAFAQPLEFTVNQSASYLPIGSSTIAISVPILIFGTLAYLQDKLLAPLILGTAIAAAGIWIVEKSRPALKIAALLHCVTVVVAFVAMALWGDRGSDEMAGFAALTWLWAITNSMFLIKSLISSRPPAKTKTQNHHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK1</accession>
    <name>A0A1U9NGK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein with PD1-like DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00002"/>
    <dbReference type="EnsemblBacteria" id="AQT66864">
        <property type="protein sequence ID" value="AQT66864"/>
        <property type="gene ID" value="STSP2_00002"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00002"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16082" checksum="8D8CDBEE3E32340D" modified="2017-06-07" version="1">MEYSVGRCGRVVSMRLFEGEDLYESIESVAKDENIRCGAVFVTGGFRKAKVVVGPEQEKPKIVPNFRNFVGPGEVLGVGTVYWDDEGPKLHIHTAAGRGEETVVGCPRGGASVFLILEVTIIEIEGVKASREFDAETGVKLLRIVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK7</accession>
    <name>A0A1U9NGK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67072">
        <property type="protein sequence ID" value="AQT67072"/>
        <property type="gene ID" value="STSP2_00212"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00212"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="93" mass="9823" checksum="95A1C139656613EC" modified="2017-06-07" version="1">MCNVYLGLKSWIFGPICGIGGADGLGCNTQSNLGIAPVKALVKLPDGHLVNKTLAEIGCFWAFFGGEKLGKSRVKLRRNGVKVSKDGVKMGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK8</accession>
    <name>A0A1U9NGK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67081">
        <property type="protein sequence ID" value="AQT67081"/>
        <property type="gene ID" value="STSP2_00221"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00221"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="242"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="489" mass="55514" checksum="6F20B00CE4A9D4EC" modified="2017-06-07" version="1">MSITLVTLGSLLIAVAWNILFWDRTYGISVPIFSAIVICVLLLYSKPRLSKAKPTLFIHLLLLIYLSVCAACYRNYLILYAAIPAVFLGLGAVAFAGQEGYAFSNFIGVFESLIKMTFAGILTAPKALGQIVNKLSRNGKASKTTLKVLVGILISIPFLAIFAGLFTSADPVFSGYVSDFFEFIWEPEIFERAAVILLMWFIFCGYLYRVAKNTSLQSHLSRTEPKRNFDGIIVFVFLIMNNLLFLGFIIIQLGYLFGGKAVIRNTSFTYAEYTHKGFYEFWAAVLLVSAIILYTEYKLRDQQGPLRQMVNFAWVALIVQTLVIIASGLKRISVYEQAYGYTYLRILVALFLLWVAGFFLLFVFKIFQKRSACWLVSAGLSLAFVFLVFVSSFSIDRYIARKNIDRYLNHGREIDMDYLSYLSTDAYPEILRLKNQAKDEHIKRSASIILRQQRETADKNLEHWASWNLSFHRVENHAPSVGLTAEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH36</accession>
    <name>A0A1U9NH36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67115">
        <property type="protein sequence ID" value="AQT67115"/>
        <property type="gene ID" value="STSP2_00256"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00256"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23236" checksum="F0F333A1583564B6" modified="2017-06-07" version="1">MEMICRDADLVRYEPVLFGDCGIVSQTICGGEGGVIAGTSFTVAGADFVSGGVEAGQVVHLYSAEEGIDGVFEIVEVAGAEELMISVIRADDENGAICDVVGSEVRYSIVSYAAQIRDVTFELTKYFGLGPGDSSSEYGLADVIDTGDLRRACVFAVLAGIYATLGRQAGDASGHWEKSLFYQRKFERAREACRIELDSDGDGVGEAEISGGGFRLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH41</accession>
    <name>A0A1U9NH41_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00394"/>
    <dbReference type="EnsemblBacteria" id="AQT67251">
        <property type="protein sequence ID" value="AQT67251"/>
        <property type="gene ID" value="STSP2_00394"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00394"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28404" checksum="59C6D35F851294A5" modified="2017-06-07" version="1">MGKRGSGWSREEVLVALRVYCALPFGRLHSGNPEIVRIAEAMGRSPGSVAMKACNLAGLDPAQKAGGLGNCSSLDKQVWDEFKSDSEKVANEAEEVYGRLVLGEELSGRDEKIGEWNGGETEVVREVKARRAQGFFRRAVMVSYDGRCAVSGVGLAELLVASHIVPWSEDEERRADPSNGILLNSFYDRSFDAGFITFDEDWRLVAARELKGREKQPGFIVENVVRREGERLRLPGRFVPDAEAMGWHRENVFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH69</accession>
    <name>A0A1U9NH69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tri1</name>
        <name evidence="11" type="ORF">STSP2_00088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00088"/>
    <dbReference type="EnsemblBacteria" id="AQT66950">
        <property type="protein sequence ID" value="AQT66950"/>
        <property type="gene ID" value="STSP2_00088"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00088"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="791"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="532"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT66950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130293" checksum="C3C9003AA52939F2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH76</accession>
    <name>A0A1U9NH76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groL_1</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">STSP2_00234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00234"/>
    <dbReference type="EnsemblBacteria" id="AQT67094">
        <property type="protein sequence ID" value="AQT67094"/>
        <property type="gene ID" value="STSP2_00234"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00234"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="57091" checksum="3D5DA66B804476F1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH99</accession>
    <name>A0A1U9NH99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66980">
        <property type="protein sequence ID" value="AQT66980"/>
        <property type="gene ID" value="STSP2_00118"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00118"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775666" evidence="1">
        <location>
            <begin position="29"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="83"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="284"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="43660" checksum="7368AEEC38BD2B01" modified="2017-06-07" version="1" precursor="true">MKVTLTRSSPFAVVVLSAFLFFNGPVFAGSLEPTSPPGPTMKTLDEIEPGIPISQEDLPLVIDQPGTYYLTENLQYNQTLGTAISINYTSAVLDMNGYTLRGMNTGTAHGVATYRADAVEIRNGSVSNFSIGVFGDFFTDNCRLTDLNVSGNINRGISLGGGHGNLVRRCTASFNGQAGIYAYSSTTITECMASNNAGQGITGGISNTVRNCIVKDNKWRGIAVGDHSIIEGNTCMNNIDVGIYVGKGSVVRGNCVKGSSVHGIAVTYGCTVTNNTAYENGNIGIHGGNGGTIIGNTAYGNQNFGIAGAAGCLISDNTSRNNVKDGIYAGNDCTVKDNNCFNNGLEGDGAGIRALSNNRIQGNHVTGNDRGIDIDSTGNLIVQNSARSNTTAYTIVGGNTVGSITSDPTTAGPWANFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD6</accession>
    <name>A0A1U9NHD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor protein ZraS</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zraS</name>
        <name evidence="4" type="ORF">STSP2_00321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00321"/>
    <dbReference type="EnsemblBacteria" id="AQT67178">
        <property type="protein sequence ID" value="AQT67178"/>
        <property type="gene ID" value="STSP2_00321"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00321"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="309"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="520" mass="56349" checksum="278784A834710B02" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ6</accession>
    <name>A0A1U9NHJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">tyrS</name>
        <name evidence="11" type="ORF">STSP2_00537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00537"/>
    <dbReference type="EnsemblBacteria" id="AQT67393">
        <property type="protein sequence ID" value="AQT67393"/>
        <property type="gene ID" value="STSP2_00537"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00537"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="340"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="402" mass="44614" checksum="B3B288BC770E5586" modified="2017-06-07" version="1">MQDPIAQQIELLKRGTVEIYRESELAQRLTEAAKEGKQLRIKLGMDPTAPDIHLGHTVVLRKLRQFQDLGHKAVLIIGDYTARIGDPTGQNTTRPMLTGEEIKSNAQTYFDQAGRILDTSPDKCEIRYNSEWLADLALADVIKLTASMTVARMLERDTFDIRYKKGDAIGIHEFLYPLMQGQDSVAIKSDVELGGTDQTFNNLVGRTLQRNDGQPPQIVITMPILVGLDGVQKMSKSKGNYIGVTDAPADMFGKVMSIGDDLMENYFTLLTDVPKDKIAELTDPAKTHPKEAKVLLGKAIVEQFYDAEEATKAAEAFEKLFAQKQVPDDMPQVRTPADEITLAKLLQHCNLVNSGGEAKRMIKQSAVSIDGEKITDPQYPVTPTDDMIVRVGKRKFAKLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK1</accession>
    <name>A0A1U9NHK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ORF">STSP2_00367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00367"/>
    <dbReference type="EnsemblBacteria" id="AQT67224">
        <property type="protein sequence ID" value="AQT67224"/>
        <property type="gene ID" value="STSP2_00367"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00367"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="315"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="381" mass="41019" checksum="8FD9DB0223927CC5" modified="2017-06-07" version="1">MSKHEHNKDEHTTADSRFMRMALDLARNGIGSVEPNPAVGCVLVKHGQVIGRGYHKAFGGPHAEVEALSDADAKKNSVRRATAYVTLEPCCHHGKTPPCTDALIEAGVSRVVVAVRDNAPHVAGNGIKALRSAGVSVTTGVLADEAMALNWWFFHYHMTGRPWVICKWAQSIDGKCAFRDSAAHGQWITNAQSRKDVHKTRRRCQAVLVGVGTVITDDPELTARPALERYPARVVLDSSLRTPLKSKLLRPADNETIIITTEQAAKEKADKLAELEATHAKVAKVTADADGKCDLGAVLKLLGKLGMSQMLVEGGPTVHAAFLKAQLANELNIYIAPKILGRTGTADISKAVTKSADMLRLKDVNTRKLGNDTLVSAICAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK5</accession>
    <name>A0A1U9NHK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_1</name>
        <name evidence="2" type="ORF">STSP2_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67257">
        <property type="protein sequence ID" value="AQT67257"/>
        <property type="gene ID" value="STSP2_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00400"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="36575" checksum="A425C5124A0586A5" modified="2017-06-07" version="1">MKTRQLGDTDLKLTTIGLGTWAIGGSWQFGWGHQDDQDSIGAIVDAVEKGINWIDTAPIYGCGHSEEIVGKALKETRQNPIIATKCGLLWDDKRRKHNNLDADSIMKECHDSLKRLGISTIDLYQMHWPQPDRKIEEAWEAMAKLKKKGDVRHIGVSNFSVPQLKRIMQIEKPASLQPPYSMIDRSIEQEILPFCGENDIGVVCYSPMQKGLLTGKYTPEKIGKLPPDDHRHRDSDFAQPKLDIHLELVEKLKPIAQRNHATLAQLAIAWVFNQPHVTSAIVGARKPHQVDDNVKAGSWEISEQDMQEISRILEKHDEKLHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL7</accession>
    <name>A0A1U9NHL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase/phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">algC</name>
        <name evidence="11" type="ORF">STSP2_00240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00240"/>
    <dbReference type="EnsemblBacteria" id="AQT67100">
        <property type="protein sequence ID" value="AQT67100"/>
        <property type="gene ID" value="STSP2_00240"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00240"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="267"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50569" checksum="796841E1292A9531" modified="2017-06-07" version="1">MDPSIFKAYDIRGLYPEQLDEESAWKIGYGTAQFLRSLLRGYERGMANAQSLCVGHDMRKHSPVLVDALIRGMNATGANVIDIGMIDTPQMYFAINHLGTCGGVQVTASHNPAQYNGFKISGLEAKPIGGDTGLKDIKHIATALLHTKGRLDGSVEKCTLWDAYRQHVLKFLNPKVKGLKIAVDASNGMAGKSVPELFGDVPVDILPINFKHDGTFKHEPNPLVEANLAELKQTVVENGCDCGICFDGDADRLIMVDEKGQTIGCDLLTALMVPYFLERNPGSAIVYDLRSSHVVQEEIIKHGGTPRRERVGHAFMKKTLRDSHAVFGGELSGHFYYKDNFYADSGMITLVHVLNILGTSDKKISELIDPLRRYYSSGEINFEVEDKAAAMKELAKVYASGKIDDLDGITIQFKDWWFNCRPSNTEPLLRLNVEASTDEQLDKVLTDIEGILGKPVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR0</accession>
    <name>A0A1U9NHR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">STSP2_00450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00450"/>
    <dbReference type="EnsemblBacteria" id="AQT67307">
        <property type="protein sequence ID" value="AQT67307"/>
        <property type="gene ID" value="STSP2_00450"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00450"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="31264" checksum="6239FC5DB8A5427A" modified="2017-06-07" version="1">MDAILEYLYQISLQERLVVLLELLLIGIVVYWAVSFLEGTRGERLFRGVLFVLVIGAFVLKVVVERFDLERVAYLYNGVALLAILIIAIAFQPEIRRALIRIGQASFLSSSPQQLTRSVEEIIKAVSQLASTRTGALLVIEQQVGLGEFVETGVRVDSKVSADLLRTIFYPGTALHDMAVVIRGDRIIAARVQLPLAEESASLSGKQIGSRHRAAMGISTSTDAIVIVVSEETGIVSLAINGHLVRNISEAQLRRHLTTAVVETTPIVEKMQEVNKSTSEGSGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI26</accession>
    <name>A0A1U9NI26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrrolidone-carboxylate peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67465">
        <property type="protein sequence ID" value="AQT67465"/>
        <property type="gene ID" value="STSP2_00612"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00612"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459816" evidence="5">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="255" mass="27563" checksum="CF3CEB8D8917EF77" modified="2017-06-07" version="1" precursor="true">MKPTTIIIALTALALTSAGCTTADRPTVLLTGFWPPSNEMLRPFSPDPELNGGTWAGQNWRNLGCDVYAYFPTFPNGTDANPAGTGTFRVDYQAVSADLDRLTRKHRPRAIIAFGRGDGPWEIEYNAINRTEWVDDYSAPTQPTSDTAITTSAPARVLNLTLPAQQIADAVNAADLPLTAWVDWTGHPGSFLCNYTAYKVAQYQRANSSPDSPNPCTAAGFIHIAPNVPTKTAQTAAKITLQQVITSLKANKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI49</accession>
    <name>A0A1U9NI49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cation:proton antiport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67603">
        <property type="protein sequence ID" value="AQT67603"/>
        <property type="gene ID" value="STSP2_00751"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00751"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="189"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36609" checksum="C391CEEDC16E6E68" modified="2017-06-07" version="1">MFYLAFTLVAVIALAAVFKWAAEHIRLPSVVALIIAGLVLAYPPIRERIIGGHEHTITMIGDAGLLALMFMAGLESSWRMLYKEKEEAAYIAVFAAFVPLVVGAAAFWLMGYELSTSLIVGVCMSISAEATRAKVLMELDKLNTRVGSALIGAGLIDDTIGLSLFVLITYFIEEGGSNEQLLVVASIICFFAGLAIKRVVGREPKTMVYLEKVLNVCLVPFFFVSIGLHFDFQSLVMNAWILVAVIAIATLGKFAGVFLTKFFLDLSYKQLHLISWSMNSRGALEMALALVAFRSGLIHSKLYSSLVVMTLVTTLVFPFIMTYMVHRDPKIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI99</accession>
    <name>A0A1U9NI99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67236">
        <property type="protein sequence ID" value="AQT67236"/>
        <property type="gene ID" value="STSP2_00379"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00379"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="90" mass="10165" checksum="734EEE63DCB72265" modified="2017-06-07" version="1">MSSGLMVLVGFDVCGVRCGWRRYERGDVDGSGLVFCDWWALAYFRYDRLCVGGYMRLSRRSRFVLWMQIKFAVTVGGCVSKMLAEGGFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH6</accession>
    <name>A0A1U9NIH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide oxidoreductase ResA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">resA_1</name>
        <name evidence="5" type="ORF">STSP2_00869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00869"/>
    <dbReference type="EnsemblBacteria" id="AQT67721">
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        <property type="gene ID" value="STSP2_00869"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00869"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="63"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22254" checksum="4CF52C7E531B4A0F" modified="2017-06-07" version="1">MTNRNLLASFIAAILLIIVILFIIDKGPYEEAQPQEAQAEKEPQTQIDKVIADADTWAPIFEQWYGKPAPELELTDITGETHNLSDYKGTNVVLVFWATWCPPCKMEIPHLKALREEMSKDELMILAISNEADRTVKSFAEQENLNYTVIATDKQLPKPYSLVTGIPTSIYLDKQGNIKLATQGLVNEEHARAIILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII6</accession>
    <name>A0A1U9NII6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase involved in intracellular survival</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00544"/>
    <dbReference type="EnsemblBacteria" id="AQT67400">
        <property type="protein sequence ID" value="AQT67400"/>
        <property type="gene ID" value="STSP2_00544"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00544"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20530" checksum="63C4C1D0B9B4E8D1" modified="2017-06-07" version="1">MTDRPRTLILNEDRIDRDLDTAIRELLSRCFPHRKPLFSRSRILGDNTPAFTVVILAGTLPIAHLAAVDRTITAGGEPFRVAGIANVCVDSPFRKQGLAGRMLDTAMQHAMKLGFDFGMLFCQGHVVNTYLRNGWQDIPPAPITYIDHGTKKQIPPNRHRLYYPLNKTTFPPGPINLQTNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ9</accession>
    <name>A0A1U9NIJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purN</name>
        <name evidence="4" type="ORF">STSP2_00702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00702"/>
    <dbReference type="EnsemblBacteria" id="AQT67554">
        <property type="protein sequence ID" value="AQT67554"/>
        <property type="gene ID" value="STSP2_00702"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00702"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="368" mass="40691" checksum="CBBBF1F673590AC4" modified="2017-06-07" version="1">MSNQITIYTDGGSRGNPGPGGSGYALYDSEGNLILGRGVYLGKTTNNVAEYTGMLEALRTASEMNFENVQVFTDSELMTKQLNGIYKVKSPNLKSIYKQCVELLDSFASWEVSHVYRENNKEADALANQAMDARADVEIEGDVPAEPKGKKLRLGVLISGGGRTMENIDKQIKAGKLNAEIAVAVCSRAKIKGVELTRKLGHKLEIVRKKDLPDLDAFSDRLVEIMDENRVDLIVQAGWLCLWKIPDKYDSRVMNIHPSLLPSFGGKGMWGNHVHQAVLDRGCKVSGCTVHFCTNEYDEGPIVIQRCCPAKPDDTPEKLASRVFAEECIAYPEAIRLFSEDRLSIRDGKVFIEEASASRKPRGQANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN2</accession>
    <name>A0A1U9NIN2_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flr</name>
        <name evidence="2" type="ORF">STSP2_00597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00597"/>
    <dbReference type="EnsemblBacteria" id="AQT67450">
        <property type="protein sequence ID" value="AQT67450"/>
        <property type="gene ID" value="STSP2_00597"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00597"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18573" checksum="6F69B116A7C6A062" modified="2017-06-07" version="1">MQERVEFSEALKTKYPEPVAYAVAKDEHGKANPITLGWFMQTSGDPAMFAIAVATTRYSVKTIRHSKCFTLVFPAGDEHDEALFFGTKSGRQVDKVGEMKVATSPASMIDSVVFDDAVANFECELAGEKLTGDHIIFIGRVVASHVNTEKVNRLYTVAPGWKMGPVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR9</accession>
    <name>A0A1U9NIR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybeZ</name>
        <name evidence="4" type="ORF">STSP2_00772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00772"/>
    <dbReference type="EnsemblBacteria" id="AQT67624">
        <property type="protein sequence ID" value="AQT67624"/>
        <property type="gene ID" value="STSP2_00772"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00772"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="104"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35270" checksum="52C788EB9F5C8F94" modified="2017-06-07" version="1">MEVKVKLAPDLDSPELFGPADKYLRKLRGSMGLRITVRDAVVTITGDPEKARKAGDIIGRMQKRLMKRGLLTEADVDEIISQAKNQIKPSKDESIIVFGHRGVIEPFTRGQLDYIRTIQKNDLTLCTGPAGTGKTYLAVAAAVSMLKQKLVRKVILARPAVEAGEKLGFLPGDLQAKVNPYLRPLFDALEEMMDFGQMRKFMEMDIIEIIPLAFMRGRTLNEAAIICDEAQNTSPSQMLMLLTRLGRGSKMIITGDITQVDLEKGKPSGMVDAWRTLKGIDGVGFVQLGKTDIVRHSLVQNIVQAYDKKKTDQNSKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS4</accession>
    <name>A0A1U9NIS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GLUG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67687">
        <property type="protein sequence ID" value="AQT67687"/>
        <property type="gene ID" value="STSP2_00835"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00835"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256707" evidence="1">
        <location>
            <begin position="22"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="592" mass="61918" checksum="DA3643618C8C01D3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY8</accession>
    <name>A0A1U9NIY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67476">
        <property type="protein sequence ID" value="AQT67476"/>
        <property type="gene ID" value="STSP2_00623"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00623"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="14406" checksum="AB0329B5BCFB9079" modified="2017-06-07" version="1">MNLYFVVMIGWMMGWPVVEDHWHRRDFVAAEWRWPSNEDHMWPSRLCMVDDLMASGRLDGLRRDEVVELLGPGQAKDDLPGGDWSGGIMYHLGPERGFIRIDSEWLFVEFDGAGIVSDYGLYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ39</accession>
    <name>A0A1U9NJ39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67952">
        <property type="protein sequence ID" value="AQT67952"/>
        <property type="gene ID" value="STSP2_01104"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01104"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12832" checksum="9E549449BC3CD126" modified="2017-06-07" version="1">MSWLTAMVTVILNVLLKWGEKRSKPSCEDGSPDKDTAKKLRNKIKDHWFCFLILLVVPLAGCSTRTVYVPAGAPVRLRETIKNAKVWVKDKQGETVAGKMDLPEGWYCLPLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ76</accession>
    <name>A0A1U9NJ76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01027"/>
    <dbReference type="EnsemblBacteria" id="AQT67875">
        <property type="protein sequence ID" value="AQT67875"/>
        <property type="gene ID" value="STSP2_01027"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01027"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="448" mass="49253" checksum="367652E5959E27EC" modified="2017-06-07" version="1">MNGWNEMTRRDAVKMGLVGAAGLTVSGSRVLAADQKAKKKKRGTGKSKPEAKAKSVIQIWMWGGPSHLDTFDPKPGAGEDYCGPYKKPISTNADGVQICEMLPKLAKHADKYSIIRSMTHGINGHETASYMVQTGHEPGRLVYPSMGAVVSVFKGYEHGYDGLVPPYIVLTQPQGRFSESGFLGPKYKPFSTGGDPARTPFAVEGIVARGISDKRQKDRRELMHSLDTLGRVMGGNEKFAELDECEEEAYDLMFGDARKLFDLGQEKEAMRERYGMNTFGQSCLAARRLVEHGVPYITINYRGWDTHKQHFETMARKLPEMDQAMSALLGDLSERGLLDSTIVWWGGEFGRGPKIQKESPWNGGRSHHGKCFSSLVAGGGFKGGRVIGASDEKGMEVAERAVYPKDLIGSMYTLLGIDPDGKLPNPRGLDVKVMPRSEKGEGRLTEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH7</accession>
    <name>A0A1U9NJH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68071">
        <property type="protein sequence ID" value="AQT68071"/>
        <property type="gene ID" value="STSP2_01226"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01226"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459818" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120926" checksum="D24F92D10B9E6131" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI6</accession>
    <name>A0A1U9NJI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prkC_1</name>
        <name evidence="5" type="ORF">STSP2_01121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67967">
        <property type="protein sequence ID" value="AQT67967"/>
        <property type="gene ID" value="STSP2_01121"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01121"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32757" checksum="F5DFA8E9B4975376" modified="2017-06-07" version="1">MPSSSVEIDGFTIIRKLGTGARSVIYLAKDDMTGNTIALKRAFLEKPEDTRIFEQIEKEYKVARQLDHPHIRKCYKLIKRRKLLRVNEVLLSMEMFEGKPLEDSPGLSLGDVILIFRMVATALNYMHQRGFVHCDIKPNNILIDGKGGLKVIDLGQSCKLGEIKQRIQGTPDYIAPEQVKRQHLSHRTDIFNLGATMYWALTGKNVPTLIPKNMDFATQVLQRREEFRAPHEIYRKIPRSLSQLVLDCVEEKPADRPESMSSIVSRLDKLIRDIFGNKLQKNGTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ0</accession>
    <name>A0A1U9NJJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67985">
        <property type="protein sequence ID" value="AQT67985"/>
        <property type="gene ID" value="STSP2_01139"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01139"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9917" checksum="15E9FEB1EDA410D8" modified="2017-06-07" version="1">MISKLISLLIAAVYITIAVLRGDPDDPFTRMVIFGIMFGLPCIWFPDTLGSIVGLVRLQLIDQETPACIMRFFGWLILIFLPLLMFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT1</accession>
    <name>A0A1U9NJT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnose operon regulatory protein RhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhaS_1</name>
        <name evidence="5" type="ORF">STSP2_01148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01148"/>
    <dbReference type="EnsemblBacteria" id="AQT67994">
        <property type="protein sequence ID" value="AQT67994"/>
        <property type="gene ID" value="STSP2_01148"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01148"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="188"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="289" mass="32746" checksum="913BF4EC9FF367B3" modified="2017-06-07" version="1">MTDPGGNVRKKFEEEQCHSDRMQQLGWARFARPVCDRENLPRHVHSDAFEICCIASGNVEWWVEGQIYNVKAGDLFITFPGESHGGLNDIMNPCELYWAQIQLNDNAGIGGLTAEDLKALKRELIDAQCRVFTGSDKIEQAFASLIAEHEKPDQFARAKVETNLAQLLIEVARACQAGQRNQISPTIQKACNTINAAFDQPIRMEDIALELDISLTAFYRQFAEQLHEKPTEYLNRLRIEHAKDLLKQTDHTITQIAHASGYSSSQYFATIFKRSTGLSPRDYRKSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT8</accession>
    <name>A0A1U9NJT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide chemoreceptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tap_2</name>
        <name evidence="6" type="ORF">STSP2_01346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01346"/>
    <dbReference type="EnsemblBacteria" id="AQT68191">
        <property type="protein sequence ID" value="AQT68191"/>
        <property type="gene ID" value="STSP2_01346"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01346"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="353"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="660" mass="71119" checksum="04EDAC23FACEA996" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY6</accession>
    <name>A0A1U9NJY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68253">
        <property type="protein sequence ID" value="AQT68253"/>
        <property type="gene ID" value="STSP2_01409"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01409"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="24114" checksum="2A31FAAC446D8629" modified="2017-06-07" version="1">MKKFDKYRPLTKQQLKEVVECYATEFPDWEIVDGNRFVRSLGPVAQEIGFQGMSYQAYRPMAYILPLPYPSIAMLHHFLDIKHDVIDMRAHPRKWRSAIAAMEEQFVPPIRQPLNLREVMRLCEQTAREKTNDLCMLAILNAYLGEKLQAKSYCERVQVAPSHMTPRPEWELEHQEFARQLLNAIESGNELKFLDDVTASGGFEIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ0</accession>
    <name>A0A1U9NJZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68135">
        <property type="protein sequence ID" value="AQT68135"/>
        <property type="gene ID" value="STSP2_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01290"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="45821" checksum="BD8894F3B5D3E50F" modified="2017-06-07" version="1">MHGDNVCWCGGTWRGASQRPPELGLLGSNDYEGYINENLLDGANEAEVNIFADIWDSDQVYAELYGMRGRFAAMRIEMLARGGMWERESDPNAFDVLVKLEDEVRELFLEKAHEVFALQIIKEGEEPFYGYGGNPGLSLKLAQCGFALVNERDWSGFGFVELIEGVFRHAKQLEGCGESMLGRIGRDVRMLGYDVLRKSIEEGRLSAEQSGRIARVLEDSWPSAEDVYDCVPVDWAGGLETLGWASSFGKISRKVKIFGGADYDVIRSAVDPGEVERELEAYYSAVLKVRGEQFEKGLRELRKLWNGARIPLRGKQPFPKCLFCNYAEVMGQVEDALEEHAVLSVALGVRGYYEENGRLPVNFGELGFKVDGDGKGFAKKVRFEVSDSDDCLVLLGEVERTKVSVALASGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK36</accession>
    <name>A0A1U9NK36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative subtilase-type serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01028"/>
    <dbReference type="EnsemblBacteria" id="AQT67876">
        <property type="protein sequence ID" value="AQT67876"/>
        <property type="gene ID" value="STSP2_01028"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01028"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="462"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="812" mass="89672" checksum="E0F23E02B059DD61" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK54</accession>
    <name>A0A1U9NK54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor CarQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">carQ</name>
        <name evidence="4" type="ORF">STSP2_01350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01350"/>
    <dbReference type="EnsemblBacteria" id="AQT68195">
        <property type="protein sequence ID" value="AQT68195"/>
        <property type="gene ID" value="STSP2_01350"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01350"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20197" checksum="C3344669F36D6448" modified="2017-06-07" version="1">MSDMSKADRFVRLLATHHGRIYAYIFTLVPNWSDADDLMQEVTAIMLRKFDDFEPGTNFVAWATSIARYEVLRLKRDKKRSSALSLDAVGQISAEMELQNNDTELRLDALKNCLSKLNEKDRRLILLKYQSDQTTRNVASTLGISIYAVYRAVDRIHSVLLRCVRRTVRQVGGVANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK96</accession>
    <name>A0A1U9NK96_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Putative acetyltransferase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01488"/>
    <dbReference type="EnsemblBacteria" id="AQT68329">
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        <property type="gene ID" value="STSP2_01488"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01488"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21662" checksum="1B42B028F62359E6" modified="2017-06-07" version="1">MQLLRCLKVDIKNILRNGLTRLKYPLYFQRMAQVGKNVIFGRNGCIIRPEEVYLGDHVFIAANFHLSARNLHIGNYVMIGPNVVIECDDHIFHCIGRRMYEVRDERTVSGINIEDDVWIGANVTILKGVTIGEGCVIGAGSVVTKSIPPYCVAFGNPCKVYRQRFDMVDLEKHLKDVRSKYTMTNIKAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE4</accession>
    <name>A0A1U9NKE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfotransferase (ASST)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01529"/>
    <dbReference type="EnsemblBacteria" id="AQT68369">
        <property type="protein sequence ID" value="AQT68369"/>
        <property type="gene ID" value="STSP2_01529"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01529"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF14269">
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    </dbReference>
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        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="530" mass="60193" checksum="D8A9B13CAFCFFD84" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH4</accession>
    <name>A0A1U9NKH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrous oxide reductase family maturation protein NosD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01170"/>
    <dbReference type="EnsemblBacteria" id="AQT68016">
        <property type="protein sequence ID" value="AQT68016"/>
        <property type="gene ID" value="STSP2_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01170"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012391816" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="349"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="496"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="3">
        <location>
            <begin position="817"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1426" mass="150068" checksum="7DFE692D76DFF9BC" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ4</accession>
    <name>A0A1U9NKJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68254">
        <property type="protein sequence ID" value="AQT68254"/>
        <property type="gene ID" value="STSP2_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01410"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20897" checksum="15C546700EBB74BA" modified="2017-06-07" version="1">MKKFDKYRPLTKKQLKEIVECYAAEFPDWEIVDGDRLVRSLGPVLQQIGFQGLSYQAYRPMGVIRALPYPSVKMLPQFLDIKHDVIDMRAHPRKWRSAIAAMEEQFVPPIRQPLNLREVMRLCEQTAREKTNDLCMLAILNAYLGEKLQAKSSGILQPLLMLAVQLTTKAYPRPTDPGCLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK5</accession>
    <name>A0A1U9NKK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombination factor protein RarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01625"/>
    <dbReference type="EnsemblBacteria" id="AQT68461">
        <property type="protein sequence ID" value="AQT68461"/>
        <property type="gene ID" value="STSP2_01625"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01625"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="352" mass="38467" checksum="A1F971A6B50CA540" modified="2017-06-07" version="1">MESEKKLDEMIDPAKLKEAASIAEGVLGQLDSILLGRPELHKMVLVGILSQGHILLEGVPGVGKTALVKSLGELLNLGFNRVQFTPDLMPGDIVGTHILQEKDSGKREMTFEPGPVFTNILLADEINRASPKTQSALLEAMQERCVTLLGKTRELPRPFFVLASQNPIELEGTYPLPEAQLDRFMFKLNVSGADADVLEEIITTRRRGEPPMPDKKLEKADLDMLFEVMDAVFLPKAVAGYISRLVAATHPENGSPAKSVKEYVSYGASPRAAISIAEASRAHAMISGRPTVGFDDVKAVAEHVLNHRMILTYKARFDGLKTFDVINDILENVSDTGVELGRDIEIAEESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK6</accession>
    <name>A0A1U9NKK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68439">
        <property type="protein sequence ID" value="AQT68439"/>
        <property type="gene ID" value="STSP2_01603"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01603"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8264" checksum="3587729E342780ED" modified="2017-06-07" version="1">MSLLRFTIVLFFWCGWVIFPCAGFWVGHLLDNLFSSHQKIFRKVGILIGFVAYTIYVWYGAIEKGFAHLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT9</accession>
    <name>A0A1U9NKT9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01720"/>
    <dbReference type="EnsemblBacteria" id="AQT68553">
        <property type="protein sequence ID" value="AQT68553"/>
        <property type="gene ID" value="STSP2_01720"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01720"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5657" checksum="0D3D10900BE91BF1" modified="2017-06-07" version="1">MPAKVDADKCTGCGACLDSCPSEAISMDGGVAVIDADACVDCGVCVDDCPVEAISME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV9</accession>
    <name>A0A1U9NKV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dipeptide chemoreceptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tap_3</name>
        <name evidence="10" type="ORF">STSP2_01741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01741"/>
    <dbReference type="EnsemblBacteria" id="AQT68573">
        <property type="protein sequence ID" value="AQT68573"/>
        <property type="gene ID" value="STSP2_01741"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01741"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="322"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="678" mass="72360" checksum="D486D2CEA46A96A6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL06</accession>
    <name>A0A1U9NL06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68270">
        <property type="protein sequence ID" value="AQT68270"/>
        <property type="gene ID" value="STSP2_01428"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01428"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="355" mass="40756" checksum="DDCDC136B0799193" modified="2017-06-07" version="1">MTNRENFLRALRRDNPQKVPFEFVLCPSQVEELKRRTGTKDFREHFGFPLRYIELNPTKMDVDYSVFYDDLPADAEPLHWNPEWGIMGVAGSTAHFQEMLHPMKNFTSVQQVLDYPWPDYLEDYRWQGVDAQIQNFVERDLIAIGNMQMTVFELAWYLRGMDKFMMDMVMDPDMANAIMDKLIELRVGMAKRFAGCGADILMLGDDVSTQEDMMMSPAMWRDTQKWRLAKVIDAARSVKPDILIFYHGDGNLQKIIPDLIEIGVDILNPVQPECMDPKEVKKLYGDNLSFWGCLGTQTTLPFGTADEVEAKCKELIETVGAGGGLLLAPTHMVEPDVPWENIEAFARAIDKYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL49</accession>
    <name>A0A1U9NL49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_6</name>
        <name evidence="2" type="ORF">STSP2_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68661">
        <property type="protein sequence ID" value="AQT68661"/>
        <property type="gene ID" value="STSP2_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01830"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="30253" checksum="3D7419B663F7CAE4" modified="2017-06-07" version="1">MKIRGFTLVELLVVIGIMGLLMAIVAPVLRTVRSKARDVCCRSNIRQLSVMMTMYDSDHGSFPLGIDNISLLPPPNGYAGNAAYDRMGIWWFNHLGLYNRFVDRGEKDVLICPARNVPTYKFETNMLVGNYGVNNSICRSAQDYIVRREFAGESLSADQVLSPSRTVLLLDSGYTMIGWWDVTRYPPYKQEPLLEKKAYVPGMSINPYKNLHEGLREDAVYGRHSNRTVNAAFVDGHVEKLSAESLKVTSEPNSEEYKNLRPLWLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC1</accession>
    <name>A0A1U9NLC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hprA</name>
        <name evidence="6" type="ORF">STSP2_01464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01464"/>
    <dbReference type="EnsemblBacteria" id="AQT68306">
        <property type="protein sequence ID" value="AQT68306"/>
        <property type="gene ID" value="STSP2_01464"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01464"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="317" mass="34505" checksum="8530B88C5DC191E7" modified="2017-06-07" version="1">MNIVLLDSHTVNPGDLSCEPLEKLGTFKLYDRTKPEQVIERSKEAEILLTNKTIIRGEHIAALPKLKYIGVLATGYNTVDIDAARKHNITVTNVPAYSTDSVAQTVFAHLLAHTQHVADHSREVSKGRWCESEDFCYWDFPLIELAGNTMGILGLGQIGKAVAQIAQAFGMNVIAHSRSEPDDKPAGVQMVGLKDLFTKSDVLSVNCPLTEQTQGLVNHDLIARMKPNAIFINTSRGPIVEEQALADALNNERIAGAGLDVLSTEPPNPDNPLLNAKNCTITPHIGWATLASRKRCLDIVAENIKAFMAGDPQNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF8</accession>
    <name>A0A1U9NLF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01742"/>
    <dbReference type="EnsemblBacteria" id="AQT68574">
        <property type="protein sequence ID" value="AQT68574"/>
        <property type="gene ID" value="STSP2_01742"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01742"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="218" mass="25132" checksum="FA461CF0DD1B3E81" modified="2017-06-07" version="1">MQKKDLKIYASMRKLVTLVTEVLEIIMSDYTPTRDDALALFQKYNESESLTKHALAVEAVMRYFADKYGEDEEKWGVIGLIHDLDYEKFPDQHCEKTEEILRENNWPEDYIRAVLSHGWQQCTDIKPEHKMEKVLFATDELTGLITSTALVRPSRSVMDMKAKSVKKKFKDKSFAAKIDRDIIKQGAELLDMELSELMTETIMGMRTAAEELDLAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI9</accession>
    <name>A0A1U9NLI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68608">
        <property type="protein sequence ID" value="AQT68608"/>
        <property type="gene ID" value="STSP2_01776"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01776"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="617" mass="70225" checksum="4F32ECD44CC01AFD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK5</accession>
    <name>A0A1U9NLK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01614"/>
    <dbReference type="EnsemblBacteria" id="AQT68450">
        <property type="protein sequence ID" value="AQT68450"/>
        <property type="gene ID" value="STSP2_01614"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01614"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="524" mass="57626" checksum="2DC4C98D66BA23A2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL4</accession>
    <name>A0A1U9NLL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC family competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02008"/>
    <dbReference type="EnsemblBacteria" id="AQT68832">
        <property type="protein sequence ID" value="AQT68832"/>
        <property type="gene ID" value="STSP2_02008"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02008"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="525"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="554"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
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        <location>
            <begin position="599"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="846" mass="91120" checksum="1A73CFC40209944F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU3</accession>
    <name>A0A1U9NLU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein, PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02080"/>
    <dbReference type="EnsemblBacteria" id="AQT68903">
        <property type="protein sequence ID" value="AQT68903"/>
        <property type="gene ID" value="STSP2_02080"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02080"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21825" checksum="A2300DC9750C99D9" modified="2017-06-07" version="1">MWQITWKGNDHMQMCERQQLLIIAVALGILGIFGAAIYAPLARQTMRLKTTKASVHDENGKVKSQIERIPSTVREKRELAAAVGDFEAKIPTERRFAQVWEQLAEVMNEEGLTDQLIQPGVEVKGKDELVCIPLSIECTGDLGQIYAFFRSLEELERLIRVDRLEISEDKDSDGKLKMTANAKIFYRRSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW5</accession>
    <name>A0A1U9NLW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68923">
        <property type="protein sequence ID" value="AQT68923"/>
        <property type="gene ID" value="STSP2_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02100"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5639" checksum="8AF96ED88F6622B3" modified="2017-06-07" version="1">MLPFGKNVLMKIDTEFSCLAGHVNKNDSLVRYIDGVNFVRTKCAQKSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW8</accession>
    <name>A0A1U9NLW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein HldE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hldE_1</name>
        <name evidence="2" type="ORF">STSP2_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02108"/>
    <dbReference type="EnsemblBacteria" id="AQT68931">
        <property type="protein sequence ID" value="AQT68931"/>
        <property type="gene ID" value="STSP2_02108"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02108"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="326" mass="35421" checksum="6C7D80E9B871BA4A" modified="2017-06-07" version="1">MYKSSETSHVIVGAGEILWDMLPGGKRLGGAPANVAFHAHAMGAVSYILSAAGDDKLGSEIRDKLSQLGVGLEYLSTNEYPTGTVDVELDVNGTAEYIITENTAWDFISWQDGFEELAGRCNAVCFGSLAQRSPVSRATIRRFLQHTAKDCLKVFDINLRQSFYSAEIIEESLAAANILKLNDGELEVISEMLGIHGDQESRLNQILKKYQLHFVALTRDSKGSIMLSSDEVSYCPGFPVDVKDTIGAGDAFTASTIVSRLQGLSLDETNILANRVAGFVCGRAGATPQLPAELTGGFKRTHSERAKIELKSKRGRDDELLTKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX0</accession>
    <name>A0A1U9NLX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biopolymer transport protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68797">
        <property type="protein sequence ID" value="AQT68797"/>
        <property type="gene ID" value="STSP2_01970"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01970"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14755" checksum="7871561855C521DE" modified="2017-06-07" version="1">MGRFRQAAMDEGNEAGIDISPLMDCVFILLIFFIVTTTFVEETGVEVDKPQAASSVQQEKNSILIALTEKGEVVYGGREIGFSGIRPLVKRMLQKEEIPVIIQADTAAPSGMLVRVIDEAKLAGAETVSLSTLKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY3</accession>
    <name>A0A1U9NLY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68744">
        <property type="protein sequence ID" value="AQT68744"/>
        <property type="gene ID" value="STSP2_01916"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01916"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012685378" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="22530" checksum="C70799F4D7B6B791" modified="2017-06-07" version="1" precursor="true">MKKLVMIVMMCLAVVSGSSAGLISNGDFSAGPDGSNADNWAKLDGATSEVYYQGGWEGDYPDTQYASGRALSIQAVETYGAQQVLGAVVGQYEVSFAAGYRNDAVTGGDIDLRVSIWDTVSDFELAGETITIADPGLAAGGLSDADWGAFSEKTLSFSFDPSNVSEAALRFVNTSTGSWAQTALIDNVSVTPEPATMMLLGLGALTLRRRRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM17</accession>
    <name>A0A1U9NM17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68774">
        <property type="protein sequence ID" value="AQT68774"/>
        <property type="gene ID" value="STSP2_01946"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01946"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="11061" checksum="6B783FEC569B7D9E" modified="2017-06-07" version="1">MSLIPALLIIMAHLFFVACDVILLMIILQAVYDRWQFPRLEQTIKAISPLIDYILGLLDRFLSHMINETYSRRTLLAVTAISICLLRIVISNILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM20</accession>
    <name>A0A1U9NM20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68857">
        <property type="protein sequence ID" value="AQT68857"/>
        <property type="gene ID" value="STSP2_02033"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02033"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="456" mass="51275" checksum="3A79156310A0B471" modified="2017-06-07" version="1">MRKVWAVARNTISQILRMKVALLVIVGLLIILPLMGMIVTGDGTLKGKLQTFISYGLSLTGMLLSILTIIVATYTLTSDLKYKQIYLILSKPVHRFQIVCGKLLGIVILDAFLLAVFAAIIYGLTMFMPKLADADETEMAQAQREFFTARASVEDPIDLQDVVKEVRERYQRLKRQGQIPEGMGEQEALNELFNQERIRRNAVAVGKSREWEFEDVKLLGDDEHFSIEYKYNVAVNPPDSKVYGTWFVGDLRQETEADVGEWETPIYRLDPADVIRTVQEIQVPADAIAADGYVAARFVNTYQNNTTVIPKDVKLLYESGTFEGNFVRAVLMIMTKLTFLAALGVFVSTWLSFPVGVLVSVAVFFIGTFNGFMLDSFTTLSHDITAVYYSIFKGFLWLLPQFDGRFNPTEYMIGAEAISMSVLSQAMFYTVIIKAGILTLLGIVFFRLREVAKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM85</accession>
    <name>A0A1U9NM85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68917">
        <property type="protein sequence ID" value="AQT68917"/>
        <property type="gene ID" value="STSP2_02094"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11909" checksum="E75D3CB0B599B034" modified="2017-06-07" version="1">MRVICSHAAIFRIKCWCACVQWLSDQCRNGTGLYFEPGLDRVIHVEKGGWGIFNPDGFKHRCIDTIIAFNAISHDTGGFESLAISSQKQWDVLGKIKDFYYTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF1</accession>
    <name>A0A1U9NMF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein YycF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yycF_2</name>
        <name evidence="3" type="ORF">STSP2_02085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02085"/>
    <dbReference type="EnsemblBacteria" id="AQT68908">
        <property type="protein sequence ID" value="AQT68908"/>
        <property type="gene ID" value="STSP2_02085"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14320" checksum="ED1BEA844CA16062" modified="2017-06-07" version="1">MDKKKALVVDDEIHIVQVVAIKLRNNGFEVMTADNGQKALDVAKDFQPDIVVTDYQMPFMDGVELIESLRQNEDTKQTPVIMLTARGFAIEDERREKLQISDFLSKPFSPRQLLASVEQALGETVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI4</accession>
    <name>A0A1U9NMI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_17</name>
        <name evidence="6" type="ORF">STSP2_02306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69119">
        <property type="protein sequence ID" value="AQT69119"/>
        <property type="gene ID" value="STSP2_02306"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02306"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012934057" evidence="4">
        <location>
            <begin position="26"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="559" mass="63391" checksum="0FE3A83329610065" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML0</accession>
    <name>A0A1U9NML0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">STSP2_02348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02348"/>
    <dbReference type="EnsemblBacteria" id="AQT69161">
        <property type="protein sequence ID" value="AQT69161"/>
        <property type="gene ID" value="STSP2_02348"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02348"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="316" mass="33913" checksum="00C2C713F2B33720" modified="2017-06-07" version="1">MKTAFLFPGQGAQFVGMGKDLAEEFEVCASVFEKANSIVGYDLRDICFNGPDEKLNSTTVSQPAIFTMSAAILELLKTLPETKDIKPDVTAGLSLGEYTALYAAGVISFEDGLKLVQKRGNAMQEAADATDGSMVSIIGLEPEKVDELCEEAAQGELLKGANYNCPGQVVVSGAKGACERALGLAEKYGAMKAVELKVAGAFHTEMMAPAGDKLKDALDSCDVNEPADTKVIANVTADYYSDSQSIRSGLVNQLVKPILWQKCMEKLLGEGVEEFYEIGPGRVLTGLMRRIHRKTRVKNISKAEAVKDLQAKLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR2</accession>
    <name>A0A1U9NMR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">exbB_3</name>
        <name evidence="9" type="ORF">STSP2_01969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01969"/>
    <dbReference type="EnsemblBacteria" id="AQT68796">
        <property type="protein sequence ID" value="AQT68796"/>
        <property type="gene ID" value="STSP2_01969"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01969"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21774" checksum="91E6E9A302851228" modified="2017-06-07" version="1">MIAIAAVSLVMFSLGMHILLRLRAKGFAKVPEKKWRKWINHPEKRKGHIGEILDFVTGGRTLKDTATYFEELRASEIVPFERDLLVMKICVSVAPLLGLLGTVTGMLATFEALASGSGGDKTMGMIAEGISEALVTTETGLVIALPGLLFQHILKRYYERYKAFLAHLETVCNQKLYKKIHKEEKPKVEQVAFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN11</accession>
    <name>A0A1U9NN11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69301">
        <property type="protein sequence ID" value="AQT69301"/>
        <property type="gene ID" value="STSP2_02490"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02490"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8759" checksum="88DD1137FD3C1DF3" modified="2017-06-07" version="1">MKNKTFITLLIASLILNVALPFTIHAVGVYYRNLNFNTLNTCEVSGARLAKVLLDRIEFHTSTRQTANHVLAEKGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN37</accession>
    <name>A0A1U9NN37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02341"/>
    <dbReference type="EnsemblBacteria" id="AQT69154">
        <property type="protein sequence ID" value="AQT69154"/>
        <property type="gene ID" value="STSP2_02341"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02341"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013115396" description="NfeD domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="471"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="532" mass="57606" checksum="1DDD5F3A1E858468" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN50</accession>
    <name>A0A1U9NN50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmF</name>
        <name evidence="5" type="ORF">STSP2_02345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02345"/>
    <dbReference type="EnsemblBacteria" id="AQT69158">
        <property type="protein sequence ID" value="AQT69158"/>
        <property type="gene ID" value="STSP2_02345"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02345"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6788" checksum="3C133C017739F596" modified="2017-06-07" version="1" precursor="true">MLPKKKISKARTRTRRSHHALGATNYSLCAKCGNAKLPHAACDKCGYVNSKITLELGKEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN68</accession>
    <name>A0A1U9NN68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02143"/>
    <dbReference type="EnsemblBacteria" id="AQT68966">
        <property type="protein sequence ID" value="AQT68966"/>
        <property type="gene ID" value="STSP2_02143"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02143"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="908" mass="94256" checksum="869820C00FA55D8B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE1</accession>
    <name>A0A1U9NNE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Tyrosine-protein kinase YwqD</fullName>
            <ecNumber evidence="20">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ywqD_1</name>
        <name evidence="20" type="ORF">STSP2_02652</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="20"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02652"/>
    <dbReference type="EnsemblBacteria" id="AQT69462">
        <property type="protein sequence ID" value="AQT69462"/>
        <property type="gene ID" value="STSP2_02652"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02652"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="18">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="19">
        <location>
            <begin position="541"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="354"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AQT69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="739" mass="83695" checksum="FED4EF855F9EB22C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN5</accession>
    <name>A0A1U9NNN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02755"/>
    <dbReference type="EnsemblBacteria" id="AQT69562">
        <property type="protein sequence ID" value="AQT69562"/>
        <property type="gene ID" value="STSP2_02755"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02755"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31973" checksum="97AC19F43574A97D" modified="2017-06-07" version="1">MLKFWQFLAAVDQPQPSWLGALELLILITGCGLLIRWAQNGFGARALAHKPSRRHSMTPWLPFGILILWFGLLVVAGSAITAFFDTADETVKLMALYISTGCVDILLTLTILVLGHFYFTRGLAGFGLSLCTVTKDALWGLIHYLAVMPLVVGTIYLIQFIGEAISGDGFQLPMHESLKAIMDNPSLPVVVAIAVSVIVIIPIFEELLFRGLLQSSLVSYMGNWPGIAATSLIFAVLHANWTHWLPLFLLSCGFGYAYEKSGSLWRPIFMHMIFNGTNVAMLVFQPNLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP1</accession>
    <name>A0A1U9NNP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csp_2</name>
        <name evidence="4" type="ORF">STSP2_02606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69417">
        <property type="protein sequence ID" value="AQT69417"/>
        <property type="gene ID" value="STSP2_02606"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02606"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7243" checksum="ED2E1CD7670053A4" modified="2017-06-07" version="1">MSDGIVKWFDRKKGYGFISCGPDPDVFIHHSNLVDRAKLPNEGDRVQFEVESGEKGPVAKRVAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT2</accession>
    <name>A0A1U9NNT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolG_7</name>
        <name evidence="3" type="ORF">STSP2_02647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69457">
        <property type="protein sequence ID" value="AQT69457"/>
        <property type="gene ID" value="STSP2_02647"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02647"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="340" mass="38465" checksum="BFE42EAA10EF118F" modified="2017-06-07" version="1">MLNGGVIGFGRMGITHYAILNTHPAVNITCVCESSNFVRKQLKRYADVNLYGSYKKMLSKEDLHFVIVATPTAYHADIVSDALDSNTAVFVEKPLALRRDESSSLTDKAASKNAVNQVGYFLRFNEVFKTVKDIVDHGYIGDVIHYKNEMYGRTVLKSSKSWRSKGELGGGCILDFASHCIDLAQFMFGPVSRVGGSMLKTIYSEKVEDAVYTMLEHENGLSGNVMVTWSDESYRKPFNRIEILGSQGKIIADRQEYRLYLRKDPDPESPYTKGWNIHYLPELDQPVRYSLRGSEFTLQLDHFIQSVIENDTQGACTFEDGERADRVIDMIREDFISRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP11</accession>
    <name>A0A1U9NP11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69537">
        <property type="protein sequence ID" value="AQT69537"/>
        <property type="gene ID" value="STSP2_02728"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02728"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010710918" evidence="2">
        <location>
            <begin position="26"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="543" mass="60665" checksum="3FFA1766A6DA15D2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP81</accession>
    <name>A0A1U9NP81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69607">
        <property type="protein sequence ID" value="AQT69607"/>
        <property type="gene ID" value="STSP2_02801"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02801"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="593" mass="65774" checksum="CF6E5BA637407C98" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC0</accession>
    <name>A0A1U9NPC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69685">
        <property type="protein sequence ID" value="AQT69685"/>
        <property type="gene ID" value="STSP2_02880"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02880"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="747" mass="87153" checksum="DDE954FE8CB007CB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI8</accession>
    <name>A0A1U9NPI8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplD</name>
        <name evidence="6" type="ORF">STSP2_03050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03050"/>
    <dbReference type="EnsemblBacteria" id="AQT69852">
        <property type="protein sequence ID" value="AQT69852"/>
        <property type="gene ID" value="STSP2_03050"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03050"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22455" checksum="B0F5B8BC97C75253" modified="2017-06-07" version="1">MIDVAVYNREGKEVESLQVDEAVFGGSVRYPLLKQAIVMYHANKRVGTAANKSRGMVAGSTRKLFRQKGTGNARVGNSRTNKRVGGGVAFAKGVRDYGKDMPKKQRRLARDSAILAKLQAGGVVVVDELTMDAPKTKDFAGVLKNLKIDRSCLVTLSEQDTNIYKSARNVPKVSVLDVAQLNAGDICNRQKMLITKDALMSLVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ1</accession>
    <name>A0A1U9NPJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">STSP2_03027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03027"/>
    <dbReference type="EnsemblBacteria" id="AQT69829">
        <property type="protein sequence ID" value="AQT69829"/>
        <property type="gene ID" value="STSP2_03027"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03027"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13459" checksum="31BA304CBC7A65C3" modified="2017-06-07" version="1">MAKSTKRKVRKNIAKGIVNIKATFNNTLVTITDMDGAAICQCSGGQVGFKGSRKSTPFAAQRAAENAAKTAMRNGVREVEIKVNGPGSGRESAISALQQAGLRIAAIEDITPIPHNGCRPRKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ2</accession>
    <name>A0A1U9NPJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yadH</name>
        <name evidence="8" type="ORF">STSP2_02858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02858"/>
    <dbReference type="EnsemblBacteria" id="AQT69664">
        <property type="protein sequence ID" value="AQT69664"/>
        <property type="gene ID" value="STSP2_02858"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02858"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29798" checksum="3009F1ADEFA10AE7" modified="2017-06-07" version="1">MAHSNRTREYPPLYKRLYSVWYRHMRTYTRHIVSNGFPPFLEPMIFLAGIGLGLGRYVDENVQGLPYIEFLGTGLLVTTAMFTAAYECSFGTFIRLEFDKVYDGMLAAPITTNNLIVGEMLWAGTKGLFFSFAVLCVLSVFGVVPLPASLLAPVMGFVTAFMFSTMSLFIASFVRTINHFNFYFTGFISPMFFFSGVVFPVTNLPDYIQPFSQLVPLTHSVNLVRAICTNSFHLGLLWDILYIVVFSVVFGLLAVKRLRTRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM3</accession>
    <name>A0A1U9NPM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02753"/>
    <dbReference type="EnsemblBacteria" id="AQT69560">
        <property type="protein sequence ID" value="AQT69560"/>
        <property type="gene ID" value="STSP2_02753"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02753"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23609" checksum="A307A9E5120866A3" modified="2017-06-07" version="1">MHVPWGDTLDGWEYENCCVIVAHPDDETIWCGGLILTHPESNWHVVCLCRRSDPDRAPKFRRVLDFYQASGVMGDLDDSPGLPPLSNEAVSKCVHQLLNDHSYDLIITHGPRGEYTRHIRHEEVSRAVTAMFCDHELPTGDLWTFAYFDDGGTQSPHAQPNADIILHLDEATLQTKRRLVTEYYGFLPESFEAKAVTSPEAFCRIQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN8</accession>
    <name>A0A1U9NPN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03091"/>
    <dbReference type="EnsemblBacteria" id="AQT69891">
        <property type="protein sequence ID" value="AQT69891"/>
        <property type="gene ID" value="STSP2_03091"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03091"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="703" mass="78474" checksum="4E1E9BC4F77200E1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ4</accession>
    <name>A0A1U9NPQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_3</name>
        <name evidence="2" type="ORF">STSP2_02783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02783"/>
    <dbReference type="EnsemblBacteria" id="AQT69590">
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        <property type="gene ID" value="STSP2_02783"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02783"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28905" checksum="EB012AAA798841C7" modified="2017-06-07" version="1">MITISVANQKGGCGKTTTAVNLSAALAMTGKRVVLIDLDPQGHATLGVGCDPDQCERTIYDVMSNGLTPFSFASSRTSVNGLDIVPSNVLLSGLETEISTMYGREYLLHSRLGQIDNLYDVCVIDCSPSLSLLTLNALVASDGLIVPVQTQYYSLEGLKQLLETVSIVRERFNPVLDILGILLTCYESRTLLSKQVESQMRDHFGNLVFKTIIHRTVRIAESPGAGLPVVYYDPACKGSLEYKSLADEIDHEIKIRTTQASFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU4</accession>
    <name>A0A1U9NPU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermophilic glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02945"/>
    <dbReference type="EnsemblBacteria" id="AQT69748">
        <property type="protein sequence ID" value="AQT69748"/>
        <property type="gene ID" value="STSP2_02945"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02945"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12206" checksum="80DB038FA3CA1763" modified="2017-06-07" version="1">MDRKVTVIDLEKSAEYQPLLNGDPQTHGMRSGRVYLQPGEACGEHSTNAHEELLVFLGGEGTALIGPDAQPHEVAQGKVTYIPPHTTHNIKNTGTEPLVYIYCVAPVEEKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ43</accession>
    <name>A0A1U9NQ43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">STSP2_03036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03036"/>
    <dbReference type="EnsemblBacteria" id="AQT69838">
        <property type="protein sequence ID" value="AQT69838"/>
        <property type="gene ID" value="STSP2_03036"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03036"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20979" checksum="019555BB5C5227C1" modified="2017-06-07" version="1">MSRIGKKPIAIPAGVKVEIGKDKVKVTGPKGNLEQNRLPGIDLKVDEDAKQVIVSNTNEANKQYRANYGTMRALVNNMVVGTTEGFARKMEIYGTGYNIKEQGGKLVLQVGFCHPVELKMPKSVSVEIKTPATRGNDVPAVFTLSGYNKHELGQFAANVRKVRPPEPYKGKGIRFSDEYVRRKAGKSFASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ72</accession>
    <name>A0A1U9NQ72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70083">
        <property type="protein sequence ID" value="AQT70083"/>
        <property type="gene ID" value="STSP2_03285"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03285"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012934059" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33473" checksum="87E8908E967E006E" modified="2017-06-07" version="1" precursor="true">MKSKAAVILFCVFAVLIADNAVGGVWTELKWDEPLYSAGTFNPTAIYGDTIVGTYIPKDGHGSQGFVYDGNEFKKLSKPGAYSTKPYGVYDNLIVGAYNDSGSSYNYQGFVYDGESFTTLNNPHTTTTLLKAIDGDRMLASDTSTVTNDYMFDNFSWEEFEIDGAAPYTVKALDLDGDTIVGRYKDENGTNHYYVRTGDTLEILEKPGASSIHGAAVDNGLIVGTFSDDSGSHGFIYDGTSWITVDKPGAYNTSFSAIHGDTIVGRYSELNGYQYDQGVFIYTIPEPATLALLTTGLLLMRRNRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ77</accession>
    <name>A0A1U9NQ77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69975">
        <property type="protein sequence ID" value="AQT69975"/>
        <property type="gene ID" value="STSP2_03175"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03175"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21898" checksum="F1781D372B8A0441" modified="2017-06-07" version="1">MKLEYRYGQQCQGRNQRTVAEIESDDLGEIADWLQEQFEEYSDNNVIRPWESLQDPDLQDTLAEYNEDMRTRLTVALTDSPVPVYEIWHDGIAYYYRYYCKASLILMMYEHSPDDYDLVGDDSDVYNLAKLYDALARYYWGENEYEQEHLDIINRNRDKVLKLADPGGDEVAMGANAWQECIEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA0</accession>
    <name>A0A1U9NQA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69957">
        <property type="protein sequence ID" value="AQT69957"/>
        <property type="gene ID" value="STSP2_03157"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03157"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12638" checksum="0E799785E8CFC2F9" modified="2017-06-07" version="1">MQDSHSNFHFDKTPTKHKLAANIAVAMLLYVIILLAIAAGGCTDDKFVHQTFDEAGNLTSLTEITHFTAGGKEYKGLRGQAPNGWLIELEGSASQEVEIETFTAKLIEWMQAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD9</accession>
    <name>A0A1U9NQD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage portal protein, lambda family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03154"/>
    <dbReference type="EnsemblBacteria" id="AQT69954">
        <property type="protein sequence ID" value="AQT69954"/>
        <property type="gene ID" value="STSP2_03154"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03154"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006429">
        <property type="entry name" value="Phage_lambda_portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05136">
        <property type="entry name" value="Phage_portal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="517" mass="58324" checksum="7A7D5FF131F91B7C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK7</accession>
    <name>A0A1U9NQK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA deacylase ProX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proX</name>
        <name evidence="2" type="ORF">STSP2_03418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03418"/>
    <dbReference type="EnsemblBacteria" id="AQT70212">
        <property type="protein sequence ID" value="AQT70212"/>
        <property type="gene ID" value="STSP2_03418"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03418"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17451" checksum="C4A0B70C558520BD" modified="2017-06-07" version="1">MKVIDYLDEQATNYEIKEHRTAYTAQQVAQEEHVHGDNVAKSVIVRADGRHYLCVLPACYKIDWNVLKSMLGENEVTLASEAELADIFPDCQIGAEPPFGSFYGVPTIMDDRLEKCEYIVFQAGTHERAVRMNMKDYLRIETPRIFAFSYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM3</accession>
    <name>A0A1U9NQM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-lactate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ldhA</name>
        <name evidence="5" type="ORF">STSP2_03439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03439"/>
    <dbReference type="EnsemblBacteria" id="AQT70233">
        <property type="protein sequence ID" value="AQT70233"/>
        <property type="gene ID" value="STSP2_03439"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03439"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="335" mass="37382" checksum="022D64CC20F85C25" modified="2017-06-07" version="1">MKVAVFSTKPYDQRYFSNTNDGFGHEFTFFEEKLDMNTVRLANGHGGVCVFVNDVLDRDVLKQLADQGIKLVALRCAGFNNVDIEAAEEFGMHVVRVPAYSPHAVAEHTITLILALNRRINKSHARIREGNFALDGLMGFDLNDHPVGIVGTGKIGEIVARILHGFGCKLYAFDPKPSPVCEELGVEYVSLDELFQKSYIVTLHCPLMPQTHHIIDAEAISKMQECVMLINTSRGALIDTKAVIDGLKSRKIGYLGIDVYEEEGDLFFKDLSDEIIQDDQFARLLMFPNVMVTAHQAFFTHQAVQAIADTTLQNISEIEKGERCENEVTSELVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM9</accession>
    <name>A0A1U9NQM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70028">
        <property type="protein sequence ID" value="AQT70028"/>
        <property type="gene ID" value="STSP2_03230"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03230"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="50740" checksum="86FE511E00AA513C" modified="2017-06-07" version="1">MLHDPSHHTPPPVAAEIKLTDNDADILRRLAGEVAQIASLPVHKEKARLWTKLNDLQSERPMVWINEICWNEMNVNDELALRCEHPWARDQEDQLRKTIYQWRHMPADMIVNDFLVCPLAIHSTDFGIIEDVDVVKTDETSDVVSRHFNIQIKEPEDIEKIKLPKITHNEQATEFSYQAMCKVYDGIMPVHKQGQTHIWFTPWDYLIRWWGIQEAMMDMIMRPEMVHAAVDRMVDAWMVELDQFEQQNLLALDNNNTRVGSGGYGYSSELPGDNYDPDHVRPHNMWGCSNAQIFSEVSPDMQWEFAIKHDMRWLERFGLTYYGCCEPLDRKMHILRRIPNLRKISTSPWCDIERMISEVGSDYVISQKPSPAILAETDWNPKQARQNIREVLEKADGKCHIEFIMKDISTVRYEPHRLWEWSQIAMEEVSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN9</accession>
    <name>A0A1U9NQN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="12">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pdhD_2</name>
        <name evidence="12" type="ORF">STSP2_03339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03339"/>
    <dbReference type="EnsemblBacteria" id="AQT70135">
        <property type="protein sequence ID" value="AQT70135"/>
        <property type="gene ID" value="STSP2_03339"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03339"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="341"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="466" mass="50401" checksum="707211D0454962CE" modified="2017-06-07" version="1">MQSFDVAVIGGGSAGSAAVKQAARRGANACIIQDSHFGGVCLNLGCMPAKAMLYASNQYWSMKNLHSVVPGVEVSGSIDGRAFMKRVHDLVLELREKTESGMASRDDITIYRGSARLTGRHSLSIDAHDGTHEIRADSIVIATGSHPIRPGFAPWQNKRIMVSDDALQAADLPESILIIGGGVIGCEFATAYSQLGIRTHLVEMADKLVPTMDNSEISGFITSSLSGSGCEILLDTQVCGIKETSDGLSVDVNGREIQVSHVLVSVGRAANIENIGLENAGVDTREGIIAVDECCRTNIDHIYAAGDVAEHMQYAHLAERMGRVAGDNAAGGSLTDERNIVPIGIYTNPQVAIVKNRDIEFDPADLALMKYPYTESGTAKIYGYAQGKVVLRIVKETGQLVEAYWWGDHAVDMIHEAVLSIKNNIKLSTIFNTIHAHPSFQEIFSEMAENYTDRKVRKNHTINLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU7</accession>
    <name>A0A1U9NQU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69990">
        <property type="protein sequence ID" value="AQT69990"/>
        <property type="gene ID" value="STSP2_03191"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03191"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="457" mass="51169" checksum="5EAF8DCCA5C78F3B" modified="2017-06-07" version="1">MNTPRPSHENIRRTLLLQFLIGACIHLTFAAIVLNTDSACTAVKTSTTQQTWIAPDTISYVNPAEKYLSEFDRHGLLGPPNRYRTMGYPALIALTMKISPTHWITLLIYFQAVVSALIYPALSIISRTLFASTTRQLNALFIFMLFVGAYVSRVAYVLTDLIFVVSFYAGLASAMLMIIRRSWLWLIPQVLLIGYASLVRPTLYFFPVLHLAILTALAVRHCRTHKTPALKYAALILCSIIPITAIAAIPTIKNYKHYNTAVPSHVLGINAFNITGKYVLTQQNRQDLYQQYLAEIKAQPDPASEYHKRVESAVKIFKQYPLTTLRAMAGSSAKMLGITHWLPAFQHFNKSWWYLSSNARNKAENSTLVKYVSLFFAAVHLAVYAAFALFLLNLLTHKKLTFLLILLATLAYLIGPVFIAGGGARLRLPAEGIIIICALHYISHKLTSKTQPAHTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU9</accession>
    <name>A0A1U9NQU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp_2</name>
        <name evidence="10" type="ORF">STSP2_03495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03495"/>
    <dbReference type="EnsemblBacteria" id="AQT70289">
        <property type="protein sequence ID" value="AQT70289"/>
        <property type="gene ID" value="STSP2_03495"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03495"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000534">
        <property type="entry name" value="PPi_PFK_TP0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="80"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="430" mass="46756" checksum="16404C5DA5A980C4" modified="2017-06-07" version="1">MDAASKHENHLPDLAITSLGAPSADSPLTEARFVNDEERVLVHSRLSDIEPLIKNSSAPSFEIAGPRRKIFFDPKDLTCGIVTCGGLCPGLNDVIRSVTLSLLWQYKVKRVIGFRYGYNGISSNAYEDPIELTPDTVSAIQHIGGTILGSSRGPQSPADMVDQLIANNVRILYIIGGDGTFAGGHDIANEITKRQLPISVIGIPKTIDNDIYCSEKTFGFGTAVEHARSAIHSAHTEARGAWNGVGLVKLMGRDSGFIAASATLANSDVNFCLVPEVPFELDGRDGFLARLVDRINRKRHAVVVAAEGAGRYLEKTGRKDASGNEIYPDIGFFLKERIRRHFSEQNIPVTVKYIDPSYMIRSVPANAADSQFCIQLGQNAVHAGMAGKTDMFVAYWNNHFTHVPLAAAVGRRKKLDPASELWQGVIATTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV4</accession>
    <name>A0A1U9NQV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_5</name>
        <name evidence="2" type="ORF">STSP2_03518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70312">
        <property type="protein sequence ID" value="AQT70312"/>
        <property type="gene ID" value="STSP2_03518"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03518"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="37346" checksum="11C913D1208E5BAE" modified="2017-06-07" version="1">MKYRQLGNTDMNASIVGLGTWVMGGGSIWGKEPDDNESIRVVHASLDEGINLVDTAPLYGFGRSEEVVGKAIKGRRDEVILATKCGLWWHDERGSLLGPFDGEKVFKSLRPDTIEIEIEDSLKRLGTDRIDLYQTHWPAVEPEKTPIEDTMACLNKLKDQGKIRAIGVSNVSVDELKENMQHGEIVSDQFRYSMLYREPEENILPFCAENNVSTLTYMSLEQGLLTGKVGMDRDFGEDEWRSNEDWNPWFKKVNRPKILDMLAGWKGLTEKYSCTLAQLVVAWTAQQRGVTHVLCGARRVDQTLDNAKAGGLELAESDIAKIRSDVEGLGEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY7</accession>
    <name>A0A1U9NQY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69926">
        <property type="protein sequence ID" value="AQT69926"/>
        <property type="gene ID" value="STSP2_03126"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03126"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14231" checksum="885969D7DFA34B85" modified="2017-06-07" version="1">MNSTAHRSTQTPSTNRNESISAETPPQKPSQGLLFSEPAIAETGVWCELNEGIDPAQWAQLCRQLGSMSPGQFKRAQKKLLPNPDGLIQRLKRMFTPDANPNTDTPLVSLGPSGIYGNYQKEVYSGSATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR00</accession>
    <name>A0A1U9NR00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70339">
        <property type="protein sequence ID" value="AQT70339"/>
        <property type="gene ID" value="STSP2_03545"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03545"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029455">
        <property type="entry name" value="GHL15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14885">
        <property type="entry name" value="GHL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="436" mass="50814" checksum="4E25CB9EEA69EF9F" modified="2017-06-07" version="1">MTIKKKYIILALLINFSVTFSFAGPATIFLKKRELMVGDSWSSRPLAVEDAFQNLVKYDAIWCGQLITKHNYPAWELLRQRKPEQLLLFYFSSFTVQKGNSFASFEYDYINQYHPDWLLQKEVKLEAKNPDMRIRWNPSDPSHAYYDRFFIDVANPAFQDWAADNVVRLIEENAASSRFSFDGLALDNVLLDVWVHNISKRHPSWKYANKEEEWTNGFLEYLGKLKQSLNSNGYLLVVNHTLDYGSNRDGVDWTSIIARTDGLMDEKALGITSKKFFRENKWLTSLQHHEQILKKGLIDWWYCHPREDSRFTKRDFLYFYCSWMLVKQDGRSLFTASRGKRGYANSTVPWYSEYELDLGSPLAPKFKSNNCWLRKFERESLVAVNPNHSTESIDLPKDETFVDPSTSQMFKGSLSLPAQSGKILLKIGQGEGKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC4</accession>
    <name>A0A1U9NRC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70170">
        <property type="protein sequence ID" value="AQT70170"/>
        <property type="gene ID" value="STSP2_03375"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03375"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="19056" checksum="766E53A4472FD0C6" modified="2017-06-07" version="1">MCLYARDLSTSEGQQIQRILRSSKSRIKIRRGQVILASNQGYKVPAIAELVHYSPHHVRAIIKDFNQRGLKALEPKPRPGRPPEFTEDDKAIIAETAKCPPDLLDCPFKRWSLEKLREYLVQEKIVPTISIETLRTILREKKVKLRRTKTWKECNDPDLKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRJ1</accession>
    <name>A0A1U9NRJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03350"/>
    <dbReference type="EnsemblBacteria" id="AQT70146">
        <property type="protein sequence ID" value="AQT70146"/>
        <property type="gene ID" value="STSP2_03350"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03350"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18926" checksum="47E3841D2CA2F036" modified="2017-06-07" version="1">MKRTVVVLLAAVIIIAVYMAGFASRPGDPDEPIGLGIHDDIRMVYQIKTDDRKQGVGAGLYYVNKLMKAYEKLGVDSGEVYAHAVLHGDAGYWLLKDSQYDRADETRSENPNKSVVKQLLNRGVSVELCASTMRNNGWTQQDVLEGIKIVAGAYPRIIDLQLRGHAYIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRX9</accession>
    <name>A0A1U9NRX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">mntP</name>
        <name evidence="9" type="ORF">STSP2_03482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03482"/>
    <dbReference type="EnsemblBacteria" id="AQT70276">
        <property type="protein sequence ID" value="AQT70276"/>
        <property type="gene ID" value="STSP2_03482"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03482"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20080" checksum="5E0476BF0B1F500B" modified="2017-06-07" version="1">MFSVEVITIIFIAVGLAMDAFAVSVAAGAAERDLKIGHALRLAVFFGAFQALMPLVGWAAGMGFKDVVQAYDHWVAFGLLAAIGGKMIYESFKLKTEDEGTSVDVSSLVVVVVLSVATSIDALAVGVTLTLVTDHVAAAVIVIGVITFGLSLLGCRIGEKVGHWFENRIEAVGGLILIGIGVKILAEHLIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS60</accession>
    <name>A0A1U9NS60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.98</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wbpE</name>
        <name evidence="4" type="ORF">STSP2_03552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.98" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03552"/>
    <dbReference type="EnsemblBacteria" id="AQT70346">
        <property type="protein sequence ID" value="AQT70346"/>
        <property type="gene ID" value="STSP2_03552"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03552"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="40034" checksum="D2247B80B5FF6DAA" modified="2017-06-07" version="1">MQVPLLDLKAQYATIKDDILSAVSEVLETQRCIGGPKVDEFEKAVAEVCDCKYAVGTSSGTDAILATLMALDIGEGDEVITTPYTFFATAGCIARTGAKPVFVDIDPKTYNIDPAGIEAVITDNTKAIMPVHLFGQICDMDPIMAIAGTYGLAVIEDACQSVTSTYKGKKACSIGTAGCLSFFPSKNLGGIGDGGMVVTNDEKLYKQLQYLRNHGMEAQYVHKKVGGNFRLDPIQAAALLVKLPHLDEWSQGRRDNAAYYDKKFAGTCVQTPYISPDCKSIFNQYVIRVPKRDALLEHLRASDIGCNIYYPIPLHLQDCFADLNYKQGDFPVSEQAAKETIALPIYPELTDEMKDHVVKTVLDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG07</accession>
    <name>A0A1U9NG07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="7" type="ORF">STSP2_00009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00009"/>
    <dbReference type="EnsemblBacteria" id="AQT66871">
        <property type="protein sequence ID" value="AQT66871"/>
        <property type="gene ID" value="STSP2_00009"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00009"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023433168" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023433169" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24762" checksum="AE3EBA0C3C5B0BD5" modified="2017-06-07" version="1">MKIPLTKYGMPQVAVFPGLVVAAMLTIAIGGHYDVIRPGWVRGSEIVLAAVLVWVLAFFRDPERNVPADESLLLSPADGRISDITEVDEPALGGTAIRIGIFLNIFNVHINRAPCSVRIGKITYKEGEFKNACDPESARVNESNALEMQRTAQPADKLIVRQISGAIARRIVCATAEGDELTQGRRFGMIKFGSRTELYLPARENASVQVQVGDKVKAGLTVLVKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGB2</accession>
    <name>A0A1U9NGB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_00107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66969">
        <property type="protein sequence ID" value="AQT66969"/>
        <property type="gene ID" value="STSP2_00107"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00107"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32399" checksum="03F683B049DFC8B6" modified="2017-06-07" version="1">MTQKIIDFDNFSPVVRKLYHFMSPCILCPRKCGVDRIAGEKGYCAVGPEPRVSSASSHFGEESILVGRGGSGTIFFAGCNLGCIFCQNYRVSHQCIGDEITVHQLADTMLDLQVRGCENINLVSPTHQIPPIAAAIEDAHKRGLTLPIVYNSGGYDCANTLSLLEGLIDIYMPDMKYSNVQHGLQYSDVGDYPGINYSAVKEMYRQVGDLQVENGIALKGLIVRHLVLPHDLAGSTAIIDFLASQVSPHAAINIMDQYYPAYHAGEYEELCTSPQADEIAKVKEYAHKKGLRIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG1</accession>
    <name>A0A1U9NGG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67023">
        <property type="protein sequence ID" value="AQT67023"/>
        <property type="gene ID" value="STSP2_00161"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00161"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="334" mass="37089" checksum="67117DEC2B1ECCB1" modified="2017-06-07" version="1">MPKKKTKGRETIFAALTLVALAGIVSAIVVKQFHYDQSRFDPASALPEEQAGAADSSVNLKAALPQGLQAISPPEQFSRDDLYVKINGKAPVYLDAGFEQLHSLRFAAEDAQEKWMEIFVYDMAKPRNAFSVYSIQRRAESELIGVTEFAYKTSNAVFMALGPYYIELVAAEESNRLQQAMMNVAKNLVDKLGGEDTQQIEIFKYLPADGRMDQTLNLHLSNTFGSQALKNIFTVEYETFGEVQAFIAKKDNPDAAEEMAQAYQTFLTDNGAEKVGQIEGCDGGIYDFYGTTEIVCYKDEFLFGVHEAFERDPAEKLAKQILANIQEVTDSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ7</accession>
    <name>A0A1U9NGJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocholine transferase AnkX</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ankX</name>
        <name evidence="2" type="ORF">STSP2_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00199"/>
    <dbReference type="EnsemblBacteria" id="AQT67059">
        <property type="protein sequence ID" value="AQT67059"/>
        <property type="gene ID" value="STSP2_00199"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00199"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21415" checksum="A5A0089DEC0634C1" modified="2017-06-07" version="1">MVLNKKLHEAVKFNDIELAGSLISQGADVNSVIDDYASIHWAVQEGYLKMTELLLKSGAEIEVKDESHFTPVYKAVGEGHCEILKLLLQKGANPNAISDTGDTPLHIACAWGRYREAQCLIEYGAELNLQEEDGRVPLSFAVMYGHYDLVELLLNKGARISVKDDEGISPYDMAINSRDAKMIRLFENTTDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP0</accession>
    <name>A0A1U9NGP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgI_1</name>
        <name evidence="4" type="synonym">flgI</name>
        <name evidence="5" type="ORF">STSP2_00056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00056"/>
    <dbReference type="EnsemblBacteria" id="AQT66918">
        <property type="protein sequence ID" value="AQT66918"/>
        <property type="gene ID" value="STSP2_00056"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00056"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010750909" description="Flagellar P-ring protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39056" checksum="534A6DB748766555" modified="2017-06-07" version="1" precursor="true">MRKLTAIISVLIMFTAAANLARAERIKDIATIQGVRGNPLSGVGLVVGLAGTGDQSLPSQRMLTNVLRRSDLVFSPDDLPTGSIAMVMVTAELGPFDHVGKKIDVDVSAIGDADSLQGGVLLLTELKGADGQVYATAQGSIFLGGFAATGEAATATKNHPTVGRIPGGAYVERSEIATFIENIAGKQYVTLNLRNEDFTTANRMTTAINQLFPNQAHTVDASSVRVKIPPEYDREKVAFFVDSITQQEVKVDMPAIVVINERTGTIVVGEKVGISTVAISQGSLVVKVKESAMVSQPQANFSDNPGQTVAVPDTSIGVSESQGYLIPVNRVVTVSELAKALNAIGATPRDLIAIFNALKQAGALQAELKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT3</accession>
    <name>A0A1U9NGT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase FixC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00292"/>
    <dbReference type="EnsemblBacteria" id="AQT67151">
        <property type="protein sequence ID" value="AQT67151"/>
        <property type="gene ID" value="STSP2_00292"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00292"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="43929" checksum="C38E956EC3FE7413" modified="2017-06-07" version="1">MRSDVCVIGAGPAGMMAAIFAARRGLAVALVERNTTVGRKLLKTGRGRCNVTHAVGADEFARRCGKCGRFLKYSLWEFGADDMMAFLRERGVETRVDADGCVFPASDRANDVKRVLVGEAKDAGVRFLYGKRVEAVRKEGEVFRVEFAGDFVECRAVVVATGGKSWPGTGSTGDGYEIAQSLGHSVVEPKASVVPLVVEEEWVKGLRGVGVPEVRVSVRVKKKRISASGPLMFTGTGVGGPAVFDISVSVTDVLAAGEGPVELLVDFLPGRDHEQVRAMLVEEFGKHARKGLAAVLGWHVPKALAWELVMQLDMREGVKAGEVGKKKRAMLVRLLKETKMTAVATRPIAEATVTRGGVSLGEIDGRTMESKVCAGLYFAGEVMDADGPCGGYNLQIAWSTGVLAGECVLKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX8</accession>
    <name>A0A1U9NGX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00132"/>
    <dbReference type="EnsemblBacteria" id="AQT66994">
        <property type="protein sequence ID" value="AQT66994"/>
        <property type="gene ID" value="STSP2_00132"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00132"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27345" checksum="2DB98F078D473DEB" modified="2017-06-07" version="1">MPEITITDYIILAFAGLLAGFVDSIAGGGGIITVPALMAVGIPPHFALGTNKLQASFGSFTASAHYIRKNLANLRDCIAGVLFTAIGAALGTWTVQQISPAFLQAAIPLMLVAIFLYLIFSPDFGTLDKHPVMHTQAFYFTAGLALGFYDGFFGPGVGSFWTFVFVLLMGMNLRTATAHTKIMNFTSNIISLVVFIAGGHVLFTAGLIMAIGQLIGATAGSHLVITRGVKFVRIFFLTVVALTIIKLIYDTYLAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX9</accession>
    <name>A0A1U9NGX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_00155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="7">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00155"/>
    <dbReference type="EnsemblBacteria" id="AQT67017">
        <property type="protein sequence ID" value="AQT67017"/>
        <property type="gene ID" value="STSP2_00155"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00155"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="9">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="17325" checksum="C7A131E12B14608D" modified="2017-06-07" version="1">MEKIQRIGISLEGSLLDKFDELIHEKNYPNRSEAVRDLIREKLSGEKLQDPETEAVAAVHLVYDHHQTQLTEKLIRIQHSHLLKTISSMHVHIGHHECLEVILLRGKVREITRLGDQIVSLKGVTYGKINLIAAEEFLSEEEHSHGHDHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH93</accession>
    <name>A0A1U9NH93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage IV sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00318"/>
    <dbReference type="EnsemblBacteria" id="AQT67175">
        <property type="protein sequence ID" value="AQT67175"/>
        <property type="gene ID" value="STSP2_00318"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00318"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798472" evidence="1">
        <location>
            <begin position="30"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S55" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="609" mass="65620" checksum="280C3CB63339ED81" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH9</accession>
    <name>A0A1U9NHH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative serine protease HtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">htrA</name>
        <name evidence="6" type="ORF">STSP2_00408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67265">
        <property type="protein sequence ID" value="AQT67265"/>
        <property type="gene ID" value="STSP2_00408"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00408"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041517">
        <property type="entry name" value="DEGP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17815">
        <property type="entry name" value="PDZ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120692" evidence="3">
        <location>
            <begin position="25"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="250"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ_3" evidence="5">
        <location>
            <begin position="351"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="502" mass="55456" checksum="863337058968BF49" modified="2017-06-07" version="1" precursor="true">MKTPTKLLFFALAAILTAAPLLHAAPSIFDTADPKDAVVMIRVVKQDYNYVTPWKQEMMQQGVGTGFVIDGNRILTNAHNVANHRYVQVKKRDQAKRYIAKVAFAGHDCDLAILQIDDPTFYEGITPLPIGDIPAENSTVQTLGFPMGGQHISTTEGVVSRIQMGVYSHSQADQHLQVQTDAAINPGNSGGPVMQDGKVVGVAFQGMTNADNIGYMIPTTVIRHFLADCEDGTYDGFGNLGVSTFTGLHNPAYADYLGIPEGTEGLVVTSVLLNSTAEDILQENDVITKIDDYDIDNDGMIKIHGLTLNMAEAIEQKQIGETIDLTFYRDGEQHTKNVTVGLDEPVIAYSRQFDKAPRYHVFAGLTFVPISRNYLESWGGRWISKVPHTLRYLFIDSRELNDNPDRDDYVVLSQVLTDNVNSYTDDFVDKVIKSINDQPIMSLEDVPTAIAKSGDFLTIKFMGQPTPLILDYPEAAARDSKIRSNYNVTKQSNLEETHEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL6</accession>
    <name>A0A1U9NHL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase RsbU</fullName>
            <ecNumber evidence="2">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbU_1</name>
        <name evidence="2" type="ORF">STSP2_00553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00553"/>
    <dbReference type="EnsemblBacteria" id="AQT67409">
        <property type="protein sequence ID" value="AQT67409"/>
        <property type="gene ID" value="STSP2_00553"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00553"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47101" checksum="4CE70383F4DF3DCA" modified="2017-06-07" version="1">MLGKTNENIELDKILDMATMVAGDFSLQEVLDRLAEAAVKITSTTACSIRLLDEESGDLAMRSTYGLSESWRNKGPVTREDPVVKEAFSGQAVVLDDMRVDGRSQYPQAIADEGLVSQLTVAMTFKNKPIGVLRLYSPEPRRFDEDSVAIARLVATQCAIAITNAKLYSRAIRGAKVSEQMRLGAVIQRRMIPNHAPKMCGLDVAATYQPCFEIGGDLYDFIKINDHTIAIGIADVIGKGIPAAMMMSLFRGAFRAYADKAFEKRSMSEIVDKLNKVAYKECRNGEFITLFFGYIDIDKMEMTYCNCGHEPGLLMRGGKTRDLNTGGLVLGVLEDAHYDIETVKLQDHDSLLLYTDGLIDAMDFDGELWGKERMLEVLDKCVDCSAGQLIKNLLAYRRRFVGLASQVDDTSLVAVKVNTCDCDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN1</accession>
    <name>A0A1U9NHN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67016">
        <property type="protein sequence ID" value="AQT67016"/>
        <property type="gene ID" value="STSP2_00154"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00154"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9833" checksum="9269DC10ED4FEEEB" modified="2017-06-07" version="1">MNEGIEKKLNELVKEIGSIPTPQKKKLFTLIKRTDDCQKKLDKSIDGLQDSLDSLRLSVKYLIFDLEATRRENSQLKKALEDKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ9</accession>
    <name>A0A1U9NHQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Colicin I receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cirA</name>
        <name evidence="4" type="ORF">STSP2_00427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00427"/>
    <dbReference type="EnsemblBacteria" id="AQT67284">
        <property type="protein sequence ID" value="AQT67284"/>
        <property type="gene ID" value="STSP2_00427"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00427"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012662668" evidence="1">
        <location>
            <begin position="25"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="3">
        <location>
            <begin position="411"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="669" mass="75600" checksum="0602EEDC96ADA2EE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT1</accession>
    <name>A0A1U9NHT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">ndk</name>
        <name evidence="5" type="ORF">STSP2_00628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00628"/>
    <dbReference type="EnsemblBacteria" id="AQT67481">
        <property type="protein sequence ID" value="AQT67481"/>
        <property type="gene ID" value="STSP2_00628"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00628"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17330" checksum="AE69E7A783400E77" modified="2017-06-07" version="1">MSERTLIVVKPDGVQRGLAGEIISRFERKGFKLAGSKFMRVSEELARKHYQVHEGKYFYDRLVRYICSGPVLAMVWEAEGIIAMSRKMMGATFGYDAEPGTIRGDYSCSKGNNLVHGSDSVESAEFEIGLWFDEGELVSWEPANEHWLRGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT3</accession>
    <name>A0A1U9NHT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase/HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67483">
        <property type="protein sequence ID" value="AQT67483"/>
        <property type="gene ID" value="STSP2_00630"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00630"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010692723" evidence="1">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="542" mass="60642" checksum="4838A23810260C4F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX8</accession>
    <name>A0A1U9NHX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67116">
        <property type="protein sequence ID" value="AQT67116"/>
        <property type="gene ID" value="STSP2_00257"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00257"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035198">
        <property type="entry name" value="DUF5309"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17236">
        <property type="entry name" value="DUF5309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="384" mass="41411" checksum="1BE54E677531E69E" modified="2017-06-07" version="1">MAFTGKATYSAGTTLPEIAEDVSDLIGIVSPYETPVLDALGDPLRAATSPHHEWLEDELLPNKDSVNDAAISDPTGETAFDVMNGTRFRVGDQIQIEGSGELILVTDVSGNTLSVVRGYAGTTPEAVADGQVVNILGNAALEGDDKPAVRFTNRKRCGNFTQIFTAGVEVSGTDLAASQLGLSDEMDYQKQERLRELIRDLENTVINGGSPVANAQGNNSVRRTMRGIFQSLETNVFAAGDAGLPAGTDLDEEKINYILRSIWENSNGNVDLIVCGGFQKRKINGMLSGMREYAASDTVFRDMVSMYESDFGVCKVVTTRWMPMDSVLLLDSSRISVLPMAGRSFHFKPLSSSGDYECGELIGEYTLELKNEAAHGLIRGLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ8</accession>
    <name>A0A1U9NHZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tRNA (Adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tsaA</name>
        <name evidence="4" type="ORF">STSP2_00373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00373"/>
    <dbReference type="EnsemblBacteria" id="AQT67230">
        <property type="protein sequence ID" value="AQT67230"/>
        <property type="gene ID" value="STSP2_00373"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00373"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
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        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18558" checksum="8139BC9A0F8CB1B1" modified="2017-06-07" version="1">MNTQKIQIQPIGIIHSPFKQLQNMPIQPKGAPDTTGTIEIFEQYAPGLTDLAGFSHIYLLYHFHHARETRLRVTPFMDTVTRGVYSTRAPVRPNHIGLSVVELLEVQQNILTIKGVDILDGTPLIDIKPYIEKFDHPQNTRSGWMNQDQKTINQKRSDNRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI40</accession>
    <name>A0A1U9NI40_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Type III secretion low calcium response chaperone LcrH/SycD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AQT67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="309" mass="36027" checksum="ECDCAD3A9F62466A" modified="2017-06-07" version="1">MTAKKPSDDLTDKGLLLRAMRFCDPISIWECGAILDFRERYDSAKKCFKRILSLPFRDVLSCSDLKRDEVHGIKNDSRLRISQCCLNMSQYDEALKWMNQHIRFREQKYPSAYTDDEAKNILLQIETELESYEASQKLSELIAKEKWDAAEDLIKRELEREPDCAWWYSQLSSVLYEMHKYQQALEYSEMACEIAPCDPLYLWHYAGALNMLGRNREAIKIYKKILAMGPLKVGSIHTSEGIRWAKSLLNDCRYRVGLCYSDLRRKGLAKRWLKSHIENRSPGIPSIYKKSEVIAKLNSLDNAKCNTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI43</accession>
    <name>A0A1U9NI43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
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            <end position="397"/>
        </location>
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        <location>
            <begin position="512"/>
            <end position="557"/>
        </location>
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        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="557" mass="60556" checksum="9F10535DEF39C4CD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI45</accession>
    <name>A0A1U9NI45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67599">
        <property type="protein sequence ID" value="AQT67599"/>
        <property type="gene ID" value="STSP2_00747"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00747"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7603" checksum="46BA25CC7E043AD8" modified="2017-06-07" version="1">MKFSYDLVLEAVSKLRFAFRRPFFRSAALCKTVNRIAMAGFTRLADTKKLLAGKPKAVLKQLLIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI63</accession>
    <name>A0A1U9NI63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chondroitinase-AC</fullName>
            <ecNumber evidence="6">4.2.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cslA</name>
        <name evidence="6" type="ORF">STSP2_00558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.5" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67414">
        <property type="protein sequence ID" value="AQT67414"/>
        <property type="gene ID" value="STSP2_00558"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00558"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030341">
        <property type="term" value="F:chondroitin AC lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
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        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010730125" evidence="2">
        <location>
            <begin position="21"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_N" evidence="5">
        <location>
            <begin position="64"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8" evidence="3">
        <location>
            <begin position="345"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Lyase_8_C" evidence="4">
        <location>
            <begin position="604"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="719" mass="80433" checksum="D8EF6C0016FAA19C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA7</accession>
    <name>A0A1U9NIA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc ribbon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67555">
        <property type="protein sequence ID" value="AQT67555"/>
        <property type="gene ID" value="STSP2_00703"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00703"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27562" checksum="77F4F63B1A45CD02" modified="2017-06-07" version="1">MGPVLQGLMALQSVENRLRAVKSKLTRCRRRVIFQENKLRALKSELAAKKEEIKMTQVQADRLELEMKHRDDHIAKYRAALNTAKTNKEYASILTELNTSKADNSKIEAQVLELMGNIDTDKAACEEIQQQIEEQKEVVDNMRKESEAEASKYEEQIEEIQKEWDEAAKDIAPNALEIFKRVAETYDGEAIAEVEDQGDKSTSFNCSGCYMRIPAEVVNQLMTKDEIIRCSNCTRILVYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII9</accession>
    <name>A0A1U9NII9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">STSP2_00901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00901"/>
    <dbReference type="EnsemblBacteria" id="AQT67752">
        <property type="protein sequence ID" value="AQT67752"/>
        <property type="gene ID" value="STSP2_00901"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00901"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40827" checksum="D953F676C08E2922" modified="2017-06-07" version="1">MSDENSGLLAKLRELDERYAQIEKEMSDPEVASNVEKVVSLSKEQGKLRPMVEKYREYAEAVQGVEESEVMLNDPDVDPEFAELAKAEIEELSAKRDTLIEEIKETLVMADDASIGSIIMEIRAGTGGDEAALFARDLAAMYTRYAEKNGWKVETMEMSANELGGFREVILNIKGDGVWVDFGYESGGHRVQRVPETETQGRIHTSAATVAVLPEPEEVEVDIDPNDVVEHVSRAGGPGGQSVNKTNSAIKLEHVPSGITVSMRDEKSQHKNRSKAWRILRSRLYEHQMQELNQERDQQRKTMIGSGDRSQRIRTYNFPQNRLTDHRINLSLYSLDKVIMGELDEVVAALKEHDKQERLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM0</accession>
    <name>A0A1U9NIM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00736"/>
    <dbReference type="EnsemblBacteria" id="AQT67588">
        <property type="protein sequence ID" value="AQT67588"/>
        <property type="gene ID" value="STSP2_00736"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00736"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640373" evidence="6">
        <location>
            <begin position="28"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="457"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="594" mass="66954" checksum="35EA7B8AA91E4210" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM6</accession>
    <name>A0A1U9NIM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">nrdR</name>
        <name evidence="11" type="ORF">STSP2_00500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00500"/>
    <dbReference type="EnsemblBacteria" id="AQT67356">
        <property type="protein sequence ID" value="AQT67356"/>
        <property type="gene ID" value="STSP2_00500"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00500"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="10">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="20470" checksum="1BCD16E2FFAD4BA9" modified="2017-06-07" version="1">MRCPFCKENEDKVIDSRSSEGGRIIRRRRECLACNRRFTTYEKIAEGFKLTVVKRDRSRVPYDREKLISGLLKACYKRPVSADAIQDLADKVEEEIFRRFDKEVSSIFIGESAMRHLRQIDKVAYIRFASVYMDFKDAGELFEEFRQMMEEGEKAATEDEEKSDEPNSKQPKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ5</accession>
    <name>A0A1U9NIQ5_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="gene ID" value="STSP2_00853"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640372" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1060" mass="113293" checksum="E8FB1FF7D7854AB6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS0</accession>
    <name>A0A1U9NIS0_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_00638"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="NMO"/>
    </dbReference>
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        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="36631" checksum="088A7901CEB9A46E" modified="2017-06-07" version="1">MGVRVSRAMLAAAVAKEGCAGTIASVGLAQYETHPDADFTTMNREALRQEIRTARQLTDGVLGVNVMVAVTDYESLIRICVEEQVDLIISGAGLPLQLPAYTEGTDIQLVPIVSSVRSLKIICRKWARNFNRIPDGVIIEGTKAGGHLGYRIEEIESDMPSLEKTLADVLQFTRSLSVQIPVIAAGGIFSGEDIAYFMKLGASGVQMGTRFVCTEECDVHENFKKAYLNAKSSDLALVKSPVGLPGKVIKNAFVEKLNEGQRLPFKCKFQCLKTCNPATAPYCIANVLAKAAEGKMDEAFAFAGSNAWRCNEIISVKQLINKIEQEYRHVSHDVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW9</accession>
    <name>A0A1U9NIW9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpfC_1</name>
        <name evidence="12" type="ORF">STSP2_01023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67871">
        <property type="protein sequence ID" value="AQT67871"/>
        <property type="gene ID" value="STSP2_01023"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01023"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="356"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="698"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="650"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120221" checksum="479DA676F03808F6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ24</accession>
    <name>A0A1U9NJ24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA_7</name>
        <name evidence="1" type="ORF">STSP2_00873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67724">
        <property type="protein sequence ID" value="AQT67724"/>
        <property type="gene ID" value="STSP2_00873"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00873"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32954" checksum="366121845A141886" modified="2017-06-07" version="1">MEFDNSGSLTRSYVHANAQVLSQDDYTQADPVTGEPNRYYYIHDRLGSVRIVYHPAMAEPINSYTYDPYGQDFASECSPIVYPNQQTQYNPFKFTGQWHDSEFNHYYLRARMYDPFMARFTTRDPVFGKADECLTLHKYLFSLNDPVNNLDPSGKSAINIMAGLEAAATVYATGLTIATVGADLGNLDLIIAGGYVQQLSGLAFAWGYATAGAGDKVVRVSRWGKPGLGKGDWVMKGKANYLNWIFSGKLQPGMTNQFASYKTAQEFLVNSSDLVWPSGFFGFMKGLLGQRRYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ32</accession>
    <name>A0A1U9NJ32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67943">
        <property type="protein sequence ID" value="AQT67943"/>
        <property type="gene ID" value="STSP2_01095"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01095"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8896" checksum="754FA4B11815C763" modified="2017-06-07" version="1">MNNIIARKIDLTDQFQQLSESKTVGTVTVTALSGNSSEVILLGDTGDQVPLVPGEWHTFIRVDLARINVKGSAGDGVTVVGGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ58</accession>
    <name>A0A1U9NJ58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67855">
        <property type="protein sequence ID" value="AQT67855"/>
        <property type="gene ID" value="STSP2_01007"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01007"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8792" checksum="C9F25C7E3EC0B747" modified="2017-06-07" version="1">MENFNPQQLGKLLLIIAAFIALLGLAMILLPRLGLFKLPGDIFIDRKNFKFYFPLATSIILSIILTAIFWLINHFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ61</accession>
    <name>A0A1U9NJ61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67827">
        <property type="protein sequence ID" value="AQT67827"/>
        <property type="gene ID" value="STSP2_00978"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00978"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013228227" evidence="1">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28832" checksum="26936AEB92C3E6C2" modified="2017-06-07" version="1" precursor="true">MRTTLTLSLLFSLSYCTSFAATHVTPITDQPGSDIICTGPAYTYQHDVRHHGIDTNLAISGDAGFVVETDNPYASFYTDTSKGGDPAVLQYTFVAEQGALLADVTVTSLARIFEIGSSITGEYKIGTSEWIQFLSLTTGGTAHPVDEFKNVHDTTFSVRYTIDRTTAYWSNTAQLFRSWGPEPGQPGDFAFTFTASIITDPNCSLADIQGNDAFVNFDDFAALAAEYGQTAEELISDIDKSGTTDIDDLLLLAQSWLCNCYQPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA1</accession>
    <name>A0A1U9NJA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2061 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01047"/>
    <dbReference type="EnsemblBacteria" id="AQT67895">
        <property type="protein sequence ID" value="AQT67895"/>
        <property type="gene ID" value="STSP2_01047"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01047"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018638">
        <property type="entry name" value="DUF2061_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09834">
        <property type="entry name" value="DUF2061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2061" evidence="2">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8558" checksum="BAB26723FC961CE0" modified="2017-06-07" version="1">MESHWRSIFKSLSWRVLATMITFSVALFLIGEVDKAASIGVADTVIKFAIYYYHERLWTKIDFGRFSRAGSEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA4</accession>
    <name>A0A1U9NJA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ntpD</name>
        <name evidence="4" type="synonym">atpD</name>
        <name evidence="6" type="ORF">STSP2_01167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01167"/>
    <dbReference type="EnsemblBacteria" id="AQT68013">
        <property type="protein sequence ID" value="AQT68013"/>
        <property type="gene ID" value="STSP2_01167"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01167"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="23446" checksum="3CE53CFE174E92C9" modified="2017-06-07" version="1">MLNVSATRMELLQLRRRVELAARGHRLLSQKRDEISRQLVKISSSIREIRNSVEKELLETTRRFMMARATMEPEDMRAAIDVPTKKFNLAISFASIMSVKVPELTKDISGDIMCYGFSSTSGELDVALRALERAFDNLIELAEREKQAQLLAQELQKTRRRVNVLEHVVIPEIKETIKYIYDKLGEAERDNASRLMKIADIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF9</accession>
    <name>A0A1U9NJF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oprB</name>
        <name evidence="3" type="ORF">STSP2_00858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00858"/>
    <dbReference type="EnsemblBacteria" id="AQT67710">
        <property type="protein sequence ID" value="AQT67710"/>
        <property type="gene ID" value="STSP2_00858"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00858"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46879" checksum="390237EBC7D921CB" modified="2017-06-07" version="1" precursor="true">MKGDIVKLSTNKFLDLVVVAVCLSIVTGAYAVEDGFGETHAQEVLSESAGPELNLFERPGLEFDVGVTQIYQRNVRGGLSTNSGRGEYSGSFDVELAGDLEELFGFEGWRFYMLNEGSWTDSEGIDAWSVGSWFGVNGDAAGDRAWDVTELWFEKDISDELVLRLGKIDLTGGFECKGCPVSFDGNAYANDETSQFLNNALVNNPTIPFPDNGLGAVLHYYGGGMWYWSIGIADAQADARETGFSTTFHEEDYYFLIAEAGLVGHTHSANGDLLGAARFGLWYDPQDKERFDDGETHRDDRGFYISADQKVYNESHDQSQGLGVFGRYGYASGEVNEVTNFVSFGMAYTGLFEGRDTDRLGVGFASGTFSDDDAQFTDDYERVIEAYYSIDVADWISVSPSVQYVANPGGNDVASDAVVVGLRTQMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG9</accession>
    <name>A0A1U9NJG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00868"/>
    <dbReference type="EnsemblBacteria" id="AQT67720">
        <property type="protein sequence ID" value="AQT67720"/>
        <property type="gene ID" value="STSP2_00868"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00868"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="857"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1036" mass="110607" checksum="6D4A620011E0BCD5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM2</accession>
    <name>A0A1U9NJM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycofactocin system glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68121">
        <property type="protein sequence ID" value="AQT68121"/>
        <property type="gene ID" value="STSP2_01276"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01276"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11226" checksum="BEF96E76A2AB30CD" modified="2017-06-07" version="1">MNFTIIIPVWPKDNRPYGSVSIENLNCAPADIEVIHAKGFGPCRQRNTAAQNANGSILIFFDDDSCPEPDYITRLKHHFTDPTIAAAGGPNPGTITDKFTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM9</accession>
    <name>A0A1U9NJM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvoyl-dependent arginine decarboxylase AaxB</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aaxB</name>
        <name evidence="9" type="ORF">STSP2_00864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvoyl-dependent arginine decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00864"/>
    <dbReference type="EnsemblBacteria" id="AQT67716">
        <property type="protein sequence ID" value="AQT67716"/>
        <property type="gene ID" value="STSP2_00864"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00864"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20528" checksum="B08A4F11F77F8D9C" modified="2017-06-07" version="1">MQDYGGLNGVLVGNRIPKDYFVTEGTGQSDITVHAGSYHLALRNAGIEMCNIMCYSSILPKIARQIDKPAELTHGSVMETISAVATADRGQRATAGIIYGWLRRKDDGEKHGGLVCEYNGHKAEADACAELRSSLKELYTNGYSDDFDMDEIVLHSTSFVPEKRYGTALIALCFVNYVVPMLGNTQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP2</accession>
    <name>A0A1U9NJP2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">STSP2_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67800">
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        <property type="gene ID" value="STSP2_00950"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00950"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="22542" checksum="BB9A2928450DE832" modified="2017-06-07" version="1">MSDQPYKAINDFCKIITQLPDKEMAEEVVYWACYAAGKLPEPTGLEPVPKRKMNAIFWDLTIEDLRNKLIELHEKYRIDQQLLILGELEFVKNHLIGIADPKKLEKNRQLVEALEEQLKLPQNKRIECLADDSILGMMQTARDLISNFDQRRSKAENALSFIIDKQADHFTARYWSLLLEKDLQRKRKKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ9</accession>
    <name>A0A1U9NJQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative segregation and condensation protein B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ORF">STSP2_00895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00895"/>
    <dbReference type="EnsemblBacteria" id="AQT67746">
        <property type="protein sequence ID" value="AQT67746"/>
        <property type="gene ID" value="STSP2_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00895"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36010" checksum="879ED0FED0C5BA08" modified="2017-06-07" version="1">MSEEHKDMAVPQGDDLESTEGLDEGAVGDDAEVAEDSSAADGAGDTVDEQVQAAGDDSGDDANAEAAKALEPDSEEEAAADDEAGEEGSGGVEEKVEIAEQVESGDEVASVDDTADSAEGEEAGEAELSEGAESAETEEGGEIEEAEEKEEEKGPEEILTVEDTEVTVQSVVEAILFASDEAITANRLVSIIEAGSVKQVKAAIRNLNEKYEQTGASFRIEKLAGGFQMMTLNAYNHWLGKLVKVRTDSKLSQAALETLAIVAYKQPIIRADVEAIRGVSSGEMIRSLMYKGLVKITGRAEILGRPMLYGTTKKFLDCFGLASLKDLPKIDELKKPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR1</accession>
    <name>A0A1U9NJR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactosyl-beta-1-&gt;3-N-acetyl-D-hexosamine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.211</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.211" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68161">
        <property type="protein sequence ID" value="AQT68161"/>
        <property type="gene ID" value="STSP2_01316"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01316"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050500">
        <property type="term" value="F:1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="449"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="679"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="734" mass="84042" checksum="0C12A983F4E5CBFB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS1</accession>
    <name>A0A1U9NJS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67988">
        <property type="protein sequence ID" value="AQT67988"/>
        <property type="gene ID" value="STSP2_01142"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01142"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="26208" checksum="BA0DC3817CA2C2CF" modified="2017-06-07" version="1">MAIRPLFIPWPKEKTVITENLQFKWHPGFAVTQKQKSIKSLHDQATSQGYADVLEVSRKSKNKLGRDLSAFNLKIKIGSTDRFITVEAAFQGSKVFESGGPYRDIFGVEGNKAKRDPRLRDSGKLIKFSFNDKDWPLEPKTLFYDWLYLQALKQNPDLSYQLLKFDAFTDIEFNPKKSFNCQARSCALFKSLWVCGNLNECLKDINHYTALMCRHQAPQQKKLFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW6</accession>
    <name>A0A1U9NJW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="M.PbaBD1II"/>
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        <property type="protein sequence ID" value="AQT68233"/>
        <property type="gene ID" value="STSP2_01389"/>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
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    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="489" mass="55301" checksum="C55E4C77F9F63E93" modified="2017-06-07" version="1">MADNSQQIVQRLWNYCTVLRDDGMSYGDYVEQLTYLLFLKMADEQTRPPFSQKAIVPAKWDWSSLVSRDGDELETHYRHLLENLAKESGMLGVIFRKSQNKIQDPAKLNRLISLINDETWMGLSSDVKGDIYEGLLEKNAQDVKGGAGQYFTPRPLIAAMVEVMRPEPGVTICDPACGTGGFFIAAHSYLADPKRFKLDKKQKRKLRYETFAGWEIVDSAARLCVMNLMLHGIDGGEESPVRVGDSLASDPGERFNMVLTNPPFGKKSSITVTNDGGKSSKDSLTYEREDFWATTSNKQLNFLQHIKTLLKMNGSAAVVLPDNVLFEGGAGETIRRKLLQTCDVHTLLRLPTGVFYAQGVKANVLFFDRKPASEKAWTEKLWIYDLRTNMHFTLKTNPLGEADLTDFVKCYNPANRHDRKETERFKAFDYDELMSRDKASLDIFWLRDESLEDTETLPEPELIAEEIVENLQSALALFGSISDELGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK51</accession>
    <name>A0A1U9NK51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68313">
        <property type="protein sequence ID" value="AQT68313"/>
        <property type="gene ID" value="STSP2_01472"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01472"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798477" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="21265" checksum="D42CCC8AF91B42B4" modified="2017-06-07" version="1" precursor="true">MTRLALVSLVACLMAVCAPSHAGLINIDADGFADGVDISNAFAGATLSAVGSYSGLDGKVYAAEDSLASTGDMVFANNLAFGAEWSTDSDLGFALRVDFDQMADYVAIDFIGDDQADSAIVKAYNGQGQLIAAGLSYLLDNGEVAKAQINRPNYDIAYIVAGGLTIDGDAATVHLDNIEANVVPEPATLALLGVGGLTLLRKRRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK74</accession>
    <name>A0A1U9NK74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LexA repressor</fullName>
            <ecNumber evidence="9">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lexA_2</name>
        <name evidence="9" type="ORF">STSP2_01362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01362"/>
    <dbReference type="EnsemblBacteria" id="AQT68207">
        <property type="protein sequence ID" value="AQT68207"/>
        <property type="gene ID" value="STSP2_01362"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01362"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="8">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15686" checksum="712D14896DFC1124" modified="2017-06-07" version="1">MSKVDKICKPEFSEQALPVFTARISAGFPSPAADYEEGKLDLNKHLIKNPPATFFVRVTGDSMEGAGIYDGDLLIVDRSVEPKSGKVVIAVLNGELTVKRLRVYRGKYSLIAENTNYPDIKISRDMEFEVWGVVTNVIHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK99</accession>
    <name>A0A1U9NK99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68245">
        <property type="protein sequence ID" value="AQT68245"/>
        <property type="gene ID" value="STSP2_01401"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01401"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8300" checksum="F3B8B07A18A5C131" modified="2017-06-07" version="1">MGIRAITDNQGKTLDRYTICFCDGSLLNLSHNCDSPQGVFMWGEGCPSTDDKRISFDDLPSNVQRYLTRKGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA3</accession>
    <name>A0A1U9NKA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68237">
        <property type="protein sequence ID" value="AQT68237"/>
        <property type="gene ID" value="STSP2_01393"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01393"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17995" checksum="5372827726510C21" modified="2017-06-07" version="1">MSDNRQQNDSTNWPVPSVEDVELLLSFKDRFKNERTSFQVCHVELPDDAYRKQIYEIHPATNDFFRAVHKGSWVVPGFDYHPWHDEHCNEYRDAKWISTLSLKEIQMWLTYFSRELRWSAFCIEDSISRDIRSGVLPALLRSLSKVRSQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB8</accession>
    <name>A0A1U9NKB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sialidase</fullName>
            <ecNumber evidence="3">3.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nedA_3</name>
        <name evidence="3" type="ORF">STSP2_01343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01343"/>
    <dbReference type="EnsemblBacteria" id="AQT68188">
        <property type="protein sequence ID" value="AQT68188"/>
        <property type="gene ID" value="STSP2_01343"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01343"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052794">
        <property type="term" value="F:exo-alpha-(2-&gt;3)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052795">
        <property type="term" value="F:exo-alpha-(2-&gt;6)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
        <property type="term" value="F:exo-alpha-(2-&gt;8)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030185" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="798"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122257" checksum="B3FC10EBCEF9BE9E" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC0</accession>
    <name>A0A1U9NKC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">STSP2_01422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01422"/>
    <dbReference type="EnsemblBacteria" id="AQT68265">
        <property type="protein sequence ID" value="AQT68265"/>
        <property type="gene ID" value="STSP2_01422"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01422"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="304"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="426" mass="46211" checksum="330A650E6E073B02" modified="2017-06-07" version="1">MSMQDMAKQARLAGIRLAAADSETKNKALQAVIDGLRANTARIIEANTHDMEGAEADGLAKPLLKRLKFDEPKIETVIAGIESLIGLDEPVGKVQSVTELDGGLELSRVACPIGVIGVIFESRPDALVQIGTLCLKSGNACLLKGGSEAAETNRVLADVLIEAGDKAGLPSGWLGLMETRQEVSQMLGLDEYIDLIIPRGSNEFVRHIMDNSRIPVMGHADGICHVYVDEGADIHMAVRIVEDSKCQYPAVCNAAETVLVHSKIADVFLSKMKDTLEARGVDLRGDDRTVELIGCKPASEQDWRTEYLDLVLAVKVVDSLDEAVEHINEYGSGHTDAIVTKEQQSAEKFMQRVDSADVLVNCSTRFADGYRFGLGAEVGISTSKLHARGPVGLDGLMTYKYRLIGNGHIVADYAEGRKKFTHRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD0</accession>
    <name>A0A1U9NKD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68194">
        <property type="protein sequence ID" value="AQT68194"/>
        <property type="gene ID" value="STSP2_01349"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01349"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23829" checksum="06337C2D0828BDC3" modified="2017-06-07" version="1">MIFWLLLITALATAYLCLKNMNFYSMWQISFNLAVSIYLAIISAPLIVNLLRDQEKALPYNLAACMLLIAILSFVVLHIISTAVLGWRIEVTLPAFFETLGVGALGFISGYLIISFLLFTFCIMPITRKPCMDFLNGTKGPKAAFLYPVQATCSFVGQISLQPKENSVLQLAMELVDPGSKFYTPSQQEDSQRPEQEGEWGDKPESKETPISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK8</accession>
    <name>A0A1U9NKK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid A core-O-antigen ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01486"/>
    <dbReference type="EnsemblBacteria" id="AQT68327">
        <property type="protein sequence ID" value="AQT68327"/>
        <property type="gene ID" value="STSP2_01486"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01486"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="45834" checksum="D643901185CE93D2" modified="2017-06-07" version="1">MKKNNSKILIGILFILLFVYAGFSPVYWVPGMSYTVFRIAKICVISTIMIFSLLLGYLNPKRVLSNSIIIAFLFFVTTAFAVALGNEKNSTGAIFGEFSDFAFAGLTVVLFFNLHQRHPNSVNKVFKSGYVLLCFMALFPVLNFLIGWPDIQPPKFGREVLLSFWSTGFAGSRTNWSTGLALFVPISFLFTINYNHRLLVILTRLVLLSPIIASQLFCGSRGGLLATISALGYITVKCFNVRYLLILMAIIGIISICVWPFIVEHLRLGRQDISTGRLQQYGVAIEAISSPSLLGQGIDGSKRVVYHKVYEDHEVHNVVLRAMIDYGPLVYVSVVAFFIILLMRILFSAGTLVDVVCYAIILTILVTSMFEPNGFIGGFQNKFLFWAALGIVVSIEYTEQYKKSKDKRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL8</accession>
    <name>A0A1U9NKL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68337">
        <property type="protein sequence ID" value="AQT68337"/>
        <property type="gene ID" value="STSP2_01496"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01496"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33515" checksum="472089F5DC43B8BD" modified="2017-06-07" version="1">MKVLITGGAGFIASHIVEHFAGKAEITVLDNLRSGYRRNLEGRDVEFIEGSITDRAAVKRAVAGADYVFHLAAMVSVPESMQQPSECVDINVHGLLNVLKESAAADVKKLVFSSSAAIYGDNPTVPKLENMLPEPKSPYAITKLDGEYYCRMFAEEGRLETCCLRYFNVFGPRQDPNSAYAAAAVPIFISKALANEPITIFGDGTQTRDFIYVKDIVAANIYAAANENCRGVYNVAYGKRLSINDLAERIIRLTGSKSEIHYAPERPGDVKHSQACIDQIVQAGFTPDCDFDSGLLATIDYFKNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM0</accession>
    <name>A0A1U9NKM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01295"/>
    <dbReference type="EnsemblBacteria" id="AQT68140">
        <property type="protein sequence ID" value="AQT68140"/>
        <property type="gene ID" value="STSP2_01295"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01295"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="50166" checksum="9B2AF738A98C85BC" modified="2017-06-07" version="1" precursor="true">MKACCEVRCWGNFSFSVSFSISILLGICCIMAGTAEALDLAAANGKSLNRYDLETGVGENVFSSAYASVHGVAFDSRNDDIYYVTTQSWYNDINRNGVSIYGYHDNSIRMSNLAFDPASRNLVIQYDDVRSPSTYFTRYTSVQTRNVDTSATNIVARRGMWTITGWSGYYDPSPIWAKVHDYADVAVDSFNGKVYWTDRLEGTVLRRNLDGSGDVETIYSGLDNPYSLSLDVGSSKLFLSDDTGILSGSMDGAGALSDIVLFTGDRPSSVDVDPFSRELYWTQDGFVKKANYDGSGAADVTNAAGNAIGAMTIALGHDAGRTAGYAFSADVVIDASASFSGVEVNDTVSFFESGFGEGYEFCVEGTSFSSVMLSDLAGGDFEVLLWDGSEFVLDGQVSAGEGYSFAAGVERFRLLGVGLDMSGELPGSIVTGLSFADATAADVSISVVPEPATVMLLGLGGVVLLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM5</accession>
    <name>A0A1U9NKM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiQ</name>
        <name evidence="6" type="ORF">STSP2_01657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01657"/>
    <dbReference type="EnsemblBacteria" id="AQT68492">
        <property type="protein sequence ID" value="AQT68492"/>
        <property type="gene ID" value="STSP2_01657"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01657"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28099" checksum="C72965958ACBA816" modified="2017-06-07" version="1">MHHLKIDRLAMGSSPVHKLDPRTKLAAAIVYSLLVISVPPVSVAVLFVYAVGPFVFLTVAEVPILFVLRQVLYLVPFVAVLAVSSVWYDRSPVAVGFGPFEWETTAGVIRCVNIVLKFAITVSVLMCLGATTRFSDLTAGLDKLGVPSVLVMQLSFLYRYIFVLVDKAAHMLRARRARKMGKLPLRRELRIAGSLIGKLLGESIETAERVNLSMRARGFTGHFRLARVLKLGRGDAVFAGIFAAFTIGLMVMGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ7</accession>
    <name>A0A1U9NKQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01687"/>
    <dbReference type="EnsemblBacteria" id="AQT68522">
        <property type="protein sequence ID" value="AQT68522"/>
        <property type="gene ID" value="STSP2_01687"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01687"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="35180" checksum="22E9961D001123D0" modified="2017-06-07" version="1">MRTEKKFASLRSGFSIVELLTVMGVIAILIALLVPALNMVRDYSKEIQQKSQFHAIEVGVELFKNEFGMYPESGDNMYMDKDGDGALDGAAETYAGANKLAEAMVGWDLLGVHPKSEFMNDGLSPDDSVTIYDTNQQNLEEREEQFIELENANAFELWDIYKTNEGGEFDTNFANYVLCDVFAKGRYSGVKTGMPILYFKAHKDRYEQDSANDFTGSGSNIDDDIYDYSDNFNLVNLGDPVTGNAHPLADGEVGAGTNIAALSGAVNDTNDMADFDDMIVNDKISAISSPYKAKTYILISAGKDGLYGTSDDITNFTKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX2</accession>
    <name>A0A1U9NKX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01629"/>
    <dbReference type="EnsemblBacteria" id="AQT68465">
        <property type="protein sequence ID" value="AQT68465"/>
        <property type="gene ID" value="STSP2_01629"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01629"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32390" checksum="3E178D4415450B88" modified="2017-06-07" version="1">MKSEYRDYLLQGQQAGLRYALFTSGRISQGLAGSNLGSRAGSSLEFMEHRNYMPGDDLRHIDWGVFARSDRLCTKMFREEISPHVEIVIDGSRSMGLAGSEKARACLGLAGLLAQASINSQFTFSAWQTGDFCEKIVNGSESPAAWDGLELESIVSPGEAFKRYPPHFRPRSIRVLISDLFWVGDPRQSLMSLAANASDVVILQLVARRDVEPGDQGSLRLIDSETGQVRELFVDDAAMQRYEQNFSRHQQNWRRACTEFGGRMVTLVAEDVVKDWHLPELIESEILGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL25</accession>
    <name>A0A1U9NL25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinitrogenase iron-molybdenum cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01810"/>
    <dbReference type="EnsemblBacteria" id="AQT68642">
        <property type="protein sequence ID" value="AQT68642"/>
        <property type="gene ID" value="STSP2_01810"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01810"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11218" checksum="7692C8D490D6FA63" modified="2017-06-07" version="1">MICVTSKGSDLQSEVDPRFGRCAYFIFIDPATMEFSAVENTSMNAAQGAGISAGKTVIDGDASAVLTGECGPKAMQTLQSGDVKIYTGLNGTVEQAVQAYNEGSLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL42</accession>
    <name>A0A1U9NL42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fucP_1</name>
        <name evidence="3" type="ORF">STSP2_01820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01820"/>
    <dbReference type="EnsemblBacteria" id="AQT68651">
        <property type="protein sequence ID" value="AQT68651"/>
        <property type="gene ID" value="STSP2_01820"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01820"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="554" mass="60545" checksum="FB6DB56D5AA562CF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL81</accession>
    <name>A0A1U9NL81_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proB</name>
        <name evidence="10" type="ORF">STSP2_01423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01423"/>
    <dbReference type="EnsemblBacteria" id="AQT68266">
        <property type="protein sequence ID" value="AQT68266"/>
        <property type="gene ID" value="STSP2_01423"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01423"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39112" checksum="6412205F17D5A9E0" modified="2017-06-07" version="1">MRNFENARRVVIKIGTNTLSRGEGIDAEYMAQIAEQVAWLTEQDKQVLLVSSGAIGMGAGRIGHVGPVIDTQMRQACAAIGQPLLMHEYHRAFAERGLTVAQVLLTADVLSERKTFLNLRNAVERLLELGVVPIVNENDSVSTEEIDSAFGDNDTLSALVASKVDADLLIILSDVDALYDGDPRERADAKAIDVVWEITPAIVKAAGGAGTMHSTGGMRTKIKAARVAANAGCKIVLAHGRCEDVVRRIVSGETVGTLFMSKRKLNARTRWILNSKAAGTIHVDRGAMDALRRSKSLLPSGVVSVSGTFAAGAVVMVNEEAKAVTSLSSDELTAVAGKHSSEIREVIGADRRDVVAVPEDVVFLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA1</accession>
    <name>A0A1U9NLA1_9BACT</name>
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        <recommendedName>
            <fullName evidence="2">Dipeptidyl-peptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01673</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.</text>
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        <text evidence="1 2">Belongs to the peptidase S46 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01673"/>
    <dbReference type="EnsemblBacteria" id="AQT68508">
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    <dbReference type="KEGG" id="alus:STSP2_01673"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0043171">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="742" mass="83589" checksum="90E4A36EFFC16043" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG7</accession>
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        <submittedName>
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        </submittedName>
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    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT68647">
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        <property type="gene ID" value="STSP2_01815"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01815"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="210"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="486"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="520"/>
            <end position="527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="727" mass="79177" checksum="59950E9386EFAC25" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN4</accession>
    <name>A0A1U9NLN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01917"/>
    <dbReference type="EnsemblBacteria" id="AQT68745">
        <property type="protein sequence ID" value="AQT68745"/>
        <property type="gene ID" value="STSP2_01917"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01917"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364402" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="636" mass="67506" checksum="F0C3EF7BD92C0D1E" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT0</accession>
    <name>A0A1U9NLT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68902">
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        <property type="gene ID" value="STSP2_02079"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02079"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="214" mass="24608" checksum="EC3B68BA1398FF2E" modified="2017-06-07" version="1">MQEIDFLPKWYTTGRKKKVNYRRQYFALGVLFFVLMIWSLAGTYSVSVSKGQVRIMQRSLKNNAPIAAKYSNFEEELRKLRSQMEVIEKLKQKTRYSAALSELSYLIDEDVVLKDLVIEAKEIKRKSDGGADKVRLVGNTEKARKDLSNERKLKVILKGVAVAPSDVANLISRLERSQYFFNVMPGFSRNKVINENPVTEFEIVCHVADYVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV0</accession>
    <name>A0A1U9NLV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68777">
        <property type="protein sequence ID" value="AQT68777"/>
        <property type="gene ID" value="STSP2_01950"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01950"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3451" checksum="6E4EE97A17A576BA" modified="2017-06-07" version="1">MQKNESDRSVANLNKAIKIDESQIQNHLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM21</accession>
    <name>A0A1U9NM21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron transport complex protein RnfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01808"/>
    <dbReference type="EnsemblBacteria" id="AQT68640">
        <property type="protein sequence ID" value="AQT68640"/>
        <property type="gene ID" value="STSP2_01808"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01808"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30800" checksum="AA4EE7C1AE5B3404" modified="2017-06-07" version="1">MKELVVISGKGGTGKTSITACFGALADNGVIADCDVDAADMHLLLGPSVRARHEFVGGKLAVIDREKCTGCGVCARVCIFSAVGKADNVYRVDETACEGCKVCVEFCPVAAIDFVDSVNGDWFISDTRFGPMVHAKLGIAEENSGKLVSLIRKEARKAAEEQGKELVLVDGSPGVGCPVIASIGGADMVLIVTEPTQSGLHDLHRVAELVKHFELPGAICVNKWDINKAMSEQIETEAQEIGMPVVGRIGYDRAVTESQIARKTLVEYSKCETAERITKMWEDVTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM41</accession>
    <name>A0A1U9NM41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68660">
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        <property type="gene ID" value="STSP2_01829"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01829"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="499" mass="56167" checksum="87432F87A9C43638" modified="2017-06-07" version="1">MVDNTKQPLCDQAAIYLYDYLSKDLSADVPPEMRTHIDSCPYCQQQLKLLKQACAADIDESVDGSPNPKALNEMLSLHFEFAGREVRCRDAKPFLPSLADHELRARIVTPITAHVEHCPQCLDDLKTIAQLNLTGEQYGHLSRLLTGDENIKPQSCSDVTEHIENRICEAVPYAGLFNSCFEHNEVPASDQPKDALTDHIENCPACLQKMHELHSKIVAMADRPDSGIVTELTIEDAANDEDGAEPADVLPVHIEVRDDSQNPGEKHSRQHTGKTAAKLQRFNHGKQLMKAAVFLGAVLLIGWSLISVNTAQATDLEKIKQAMAKARNVHMAKHHPYTEEVIYEKWYSQELGIYILKNSDGTKLVDLEEKINIMIDSGGNIEKTKASDGDIENAKRQLRNGFGLVPFSETEKDKNLNWQQISSDERTKTYARKYKKEQYSGPPVPYESKFVVEADTLFPIRYESYSKTRLDRTMSLKTLITAEQISTEQMQKVIDDICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM52</accession>
    <name>A0A1U9NM52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68670">
        <property type="protein sequence ID" value="AQT68670"/>
        <property type="gene ID" value="STSP2_01839"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01839"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="163" mass="19358" checksum="D5C0A8BF30FED01B" modified="2017-06-07" version="1">MADWEIKKPLGKCVCDDQEFEVGQEYFSALLETEEGFERRDYCVECWERDRPDAYCFWKTRMADEKDKNKKIFIDDEMLMAFFERLGEETEQEKLNFRFVLTLILMQKRKLKYQSDAVVDGQEVWYMKVAGQGRTVKVVNPHLSEDQIEELSGQMGQILQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME9</accession>
    <name>A0A1U9NME9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rpsO</name>
        <name evidence="8" type="ORF">STSP2_02091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02091"/>
    <dbReference type="EnsemblBacteria" id="AQT68914">
        <property type="protein sequence ID" value="AQT68914"/>
        <property type="gene ID" value="STSP2_02091"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02091"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10139" checksum="1D98B7AFBAD3AE67" modified="2017-06-07" version="1">MLAKEKKTQIIDDYKTGDNDTGSPEVQIAILTSRINELTEHLKKHKKDHSSRRGLLKMVGTRSSLLKYVKSQDLDRYKEIISKLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI5</accession>
    <name>A0A1U9NMI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02318"/>
    <dbReference type="EnsemblBacteria" id="AQT69131">
        <property type="protein sequence ID" value="AQT69131"/>
        <property type="gene ID" value="STSP2_02318"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02318"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="487" mass="54258" checksum="A042D39763C8B00E" modified="2017-06-07" version="1">MSQTVHFTTRPEDRISISQKTAYAIGMLVNNTQAAALPAMMIILNLGLGVDVMLVGLIGFIPRIFDAVSDPMVGYISDNVRTRWGRRRPFIFVGALAAGLIFALMWQLPDGYSETFYFWVFMAASILFFLAYTIFATPFVAFGYEMTPDYHERTRLQAFANTVGQLAWLGVPWFYAIMANENLFRDKVHGARTLAIAVGIFIAVLGVVPAIFCREKFASFPKVRARKTFSQEMVDFFKGIAVTFKCKPFVKLCAATFLVFNGFQLGISFSLYIMIFYLFNGDDGNAGKLNGWFGMLTSLCTLGVIPLTAWISTKIGKRSTFLITISLSIVGYALKWFGYNPEHPYWLLFAAPLVAFGTGSLFTLMGSMIADVCDYDELKTKQRREGVFGAIYWWMVKVGMALAGLLTGILLKVSGFDETLGNAQSQETLLMLRVFDIGIPLATSLIAIFIIATYDITENRAHQIRLELESRRGKVGENSGELKQAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK6</accession>
    <name>A0A1U9NMK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Magnesium/cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02330"/>
    <dbReference type="EnsemblBacteria" id="AQT69143">
        <property type="protein sequence ID" value="AQT69143"/>
        <property type="gene ID" value="STSP2_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02330"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="37392" checksum="6BC2261F5F1C8118" modified="2017-06-07" version="1">MTVFVYILILAVLVLHGAFFSGSETGVYRLSRFKLRVGAEQHASFYGLLSRTMEDTHALVLSILIGNNLANGMATSIVTLLLVDLVGSEKAAQLYVTLIMTPVLFVFSEVIPKNIYYFRADAIMPRLAPLLWFFHKIFTWCGAVKLLSVLSRLFTRMLGTPSGGETAARAVGRSYMRQIISETHEEGILSPIQTNIMHRLVSVPTVSVGMVMMPASKVVMVNVKSGRDELMKVLEKYSYSRYPVFEHGRNHVLGFINIYETLRNDEDFHNLHRFVHKMPSLPANTSVIQAMTAMREKDQRIAIVTSGNARKSKIVGIVTMRDLVEEITGEFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP8</accession>
    <name>A0A1U9NMP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02263"/>
    <dbReference type="EnsemblBacteria" id="AQT69077">
        <property type="protein sequence ID" value="AQT69077"/>
        <property type="gene ID" value="STSP2_02263"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02263"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527456" evidence="1">
        <location>
            <begin position="26"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="638" mass="68345" checksum="261FDF10C126DA97" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ1</accession>
    <name>A0A1U9NMQ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02388"/>
    <dbReference type="EnsemblBacteria" id="AQT69201">
        <property type="protein sequence ID" value="AQT69201"/>
        <property type="gene ID" value="STSP2_02388"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02388"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="781" mass="89087" checksum="2CEEA7579DB8B92B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY4</accession>
    <name>A0A1U9NMY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH-type transcriptional regulator IscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscR_2</name>
        <name evidence="1" type="ORF">STSP2_02501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02501"/>
    <dbReference type="EnsemblBacteria" id="AQT69312">
        <property type="protein sequence ID" value="AQT69312"/>
        <property type="gene ID" value="STSP2_02501"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02501"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14617" checksum="53BAD3335868A83A" modified="2017-06-07" version="1">MKISRSTGYALVAVGYIAQNYKDGAVLAARVSKEYDIPLEYLLKILQQLVRANVLRSKRGPRGGFFLARPAEEITLLQIIEAVDGPMISHLHLAEQTNNAPFSIKMEEVCRNATEQVKEIFGSAKLSDLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN58</accession>
    <name>A0A1U9NN58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02355"/>
    <dbReference type="EnsemblBacteria" id="AQT69168">
        <property type="protein sequence ID" value="AQT69168"/>
        <property type="gene ID" value="STSP2_02355"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02355"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13251" checksum="B06667794A96E23F" modified="2017-06-07" version="1">MSGIENINDDFKRALLETIPCSVFIIDNAGRIIYWNRSIQQLTGYTADEVLGSGCENLKLTICDEGSPATSICAHLPKDSEHQMECEIRRKDGSVVPVVRTSKPVRDSRGENIGAIEALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN71</accession>
    <name>A0A1U9NN71_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">STSP2_02581</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02581"/>
    <dbReference type="EnsemblBacteria" id="AQT69392">
        <property type="protein sequence ID" value="AQT69392"/>
        <property type="gene ID" value="STSP2_02581"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02581"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="89" mass="8904" checksum="43F4324EA76FB51E" modified="2017-06-07" version="1">MFELMNFLAEVNIDDKGLGMLGGVMGAGLAVIGAGIGIGNIVGKATEAIARQPETGGRIFTTMIIGAALVEGVTLFALVICLLAVLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN82</accession>
    <name>A0A1U9NN82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sulfoacetate transporter SauU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sauU</name>
        <name evidence="7" type="ORF">STSP2_02446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02446"/>
    <dbReference type="EnsemblBacteria" id="AQT69257">
        <property type="protein sequence ID" value="AQT69257"/>
        <property type="gene ID" value="STSP2_02446"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02446"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="48411" checksum="00AC8837A495B708" modified="2017-06-07" version="1">MNSEIKKSNNFPFAPAKWPFFYGWVIVAATTIGTIASVPGQTIGVGVFTDKLINAIGLSRTQLAQAYMLGTVTSSFLLPYAGTILDKLGSRIMVMVSAAGLGVSLLLLSQIDLLTAQIESFAGLLIITAVGFLLIRFFGQGCLTLTSRVTIGKWFNHRRGLATGISSIFIAYSFNASPAFLNYLVTTFTWQQTYIILGLIIGLGITALGWVFYRDNPEQCGLIMDGKKIDPASISINKKVPETVRSFTRLEALKTFPFWIFAAATSWQALMMTAVSFHITSIGKEVALTRDQTYALFPIIGIVTAIVTILAAWISDKTRLKWFLLITLAAQFVAALGAYNISLPILQNLFIAGYAVSGSIFALLLTITWPRYYGRKHLGAISGLVTSMIVFASAIGPYIFSILRDYSGSYDLVFKLSMVVPLLLIVPGFFVVNPQLKFQDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA8</accession>
    <name>A0A1U9NNA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69287">
        <property type="protein sequence ID" value="AQT69287"/>
        <property type="gene ID" value="STSP2_02476"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02476"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="51242" checksum="D044AAF64E9400DB" modified="2017-06-07" version="1">MEYTVDSGTESESASYIYGNYIDEALLMADANGDWTHAYIHNHLYSPVAMIDWTNGAIAERCEYSVYGTATVRLPGPDNTYYALPDDDIIQDEPETANPYLYTGRRLDILDSGSLKLQYSRHRYYDAQTGRFLQKDPAGYVDGLNAYEYVRSYPILAADPTGLFVPPIIILPPGFEPPEIPRQEQYTYKMMAVDALRAFDKYHNTTEYYSTTGFSGLIDTLENTLGWVRTVKYTDKDFLYYQRSRRRLGVTWQLEDFMGKRLIYQKRYGEMLIHELVHAYLHQNGKYQGNYLGDDYYNERLAYATQYLAEGLSQFHKVDTLVKEILNGERQWDQNTKKKLRLYWNNSWRNMNRIATESRGYLNREYHDEWEEMSGIDDGGFLIGPAGVNKVKNEFGITISCRAIAGKYNKLVNGKLTCVEFVCRSPLYSDDIGVTGKLENVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND7</accession>
    <name>A0A1U9NND7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amtB_2</name>
        <name evidence="11" type="ORF">STSP2_02506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02506"/>
    <dbReference type="EnsemblBacteria" id="AQT69317">
        <property type="protein sequence ID" value="AQT69317"/>
        <property type="gene ID" value="STSP2_02506"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02506"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    <sequence length="448" mass="46751" checksum="2D8347558FA41CBF" modified="2017-06-07" version="1" precursor="true">MVKKKVSKQIPILAAVMLCSAGTVQAAESQAQSIADLKVGLDTVWVLLGAFLVFFMQAGFGMVEAGFIRAKNTCNILTKNFLDFCMASIGFFIIGYALMFGDGNGFSGLKGFMLVGAQSGADVPLFAFWLFQAAFCGAAATIVAGGMAERMKFTAYLVYSFIISALVYPIVGHWVWGGGWLAQMGFADFAGSAVVHTTGGVAALVGTILLKPRNGKYGADGKPKVIYAHSIPLAALGVFILWFGWFGFNCASTLAVGDGSLIGRVAINTNLAAAMGGVISMVTVWKRFGKPDLSMAMNGALAGLVSVTAPCAYIEPWAAMVIGGIGGWIVVRGVELLDRFMVDDPVGAFPVHGLCGIWGTLAVGIFGKSALGLAKNGLAYGGSPAQLLIQAAGVAAVAVFVLVSMGLVFKLIDVTIGLRVNDKHELEGLDIAEHGMESYGGFQIFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF9</accession>
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        <name evidence="5" type="primary">cusB</name>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
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    <sequence length="615" mass="67726" checksum="782FB4585E1F4F11" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Sproer C."/>
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            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02516"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNS_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69327.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    <sequence length="682" mass="74544" checksum="1D4A19F49DC5057F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP7</accession>
    <name>A0A1U9NNP7_9BACT</name>
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        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
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            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
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            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">STSP2_02543</name>
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    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02543"/>
    <dbReference type="EnsemblBacteria" id="AQT69354">
        <property type="protein sequence ID" value="AQT69354"/>
        <property type="gene ID" value="STSP2_02543"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02543"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36451" checksum="98AAA815090B8CCC" modified="2017-06-07" version="1">MKIYDSRTALQNLDRTGWALSIGNFDGIHIGHQQILAQARQAANDHNAPGLAVMTFDPHPVAILRPERAPGVLTPLHLKASILESLGVDTLIVIKDSYDLLNLSPTAFVDEFLMRTIKPSVLIEGPNFNFGYGRSGDINTLRELAPDRGFSVIEVPFERFTINHDDRPVNCSSTLIRQLLETGHVKDASRLLTRPYRLIGQVFAGRGIGRKLGYPTANVHPQKQIIPAEGVYAGRVSIAADYASACSADQKLPAVFSIGRAKTFVTDHPLLIEAHLLTDDHPDLYGKYLSLDFVELIRQQQRFPNEDTLKQQIHADCETASKILTLAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV6</accession>
    <name>A0A1U9NNV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02383"/>
    <dbReference type="EnsemblBacteria" id="AQT69196">
        <property type="protein sequence ID" value="AQT69196"/>
        <property type="gene ID" value="STSP2_02383"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02383"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="21660" checksum="AC155CA6FEDB62AF" modified="2017-06-07" version="1">MRALGPKSENLRTQEYIKLLAAHQSQIYAYILSMVVNYTEADEIMQETSMAMWKNFDRFEQGSDFLAWSTTIAYYQVLTFRRDRKRDSKVKFSDKFLFELKDRAPARLDLTNKRTEKLLECVKKLEKGDRELIELRYWQNLRARNIAERLNTGVRNVYYNLSRIQDLLVRCVRRSLAQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP82</accession>
    <name>A0A1U9NP82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminopeptidase YsdC</fullName>
            <ecNumber evidence="6">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ysdC_2</name>
        <name evidence="6" type="ORF">STSP2_02919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02919"/>
    <dbReference type="EnsemblBacteria" id="AQT69723">
        <property type="protein sequence ID" value="AQT69723"/>
        <property type="gene ID" value="STSP2_02919"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02919"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="374" mass="42291" checksum="2E984B8047C392B0" modified="2017-06-07" version="1">MAKTTPGKTPLQQRILKIGKELLDRPTAPFREWEVRSHIRQFCRDRDIDVREDGMGNLIATYGSEYKNDEIAFAAHMDHPGFIVETDSRGGKCRALFYGGVDEEYFKTGRVRIFAEGGDVIGKITRTEFNKKRNIKRVFMQVDGPVKKGDTGMWDLKPFSVRSDKLYSRACDDLVGCVSILSLFDELKRRRIKKKVVGVFTSAEEAGLQGAKYLCMKRKIAKKTTLIAIETSSQLGNAKMGDGVVIRVGDALSVFTPEVTAFLTSTARKLKKKDKSFKFQRKLMDGGCCESTIYQAFGYKNSAVCIALGNYHNRNFKKKQIEEEYVSVTDLEDMVKLFIATVRDVDGLSKALKPQLPKFKEEIRPLGERLFNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB6</accession>
    <name>A0A1U9NPB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-fructofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 100 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02751"/>
    <dbReference type="EnsemblBacteria" id="AQT69558">
        <property type="protein sequence ID" value="AQT69558"/>
        <property type="gene ID" value="STSP2_02751"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02751"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024746">
        <property type="entry name" value="Glyco_hydro_100"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12899">
        <property type="entry name" value="Glyco_hydro_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="409" mass="47146" checksum="501759385316B1D7" modified="2017-06-07" version="1">MNNHQWLEIENAREAAVKVLMNNMHGPCRGLPKTSAWGYYQPYTRDMMICSLGFLLSGRQELIDSLRQMLEVAARNQTSLGHITSLIHDPEDRGASDCTPLFLLGAGLYRQFTNQPDFISPAVQKALTWMMYQSPNDRVLVSQLPTSDWRDEQWVLGYGLFVNTILYACLRLFDHDGRAEQLLWEMNHFTINDHEKCGHVHEGLLLKRKPYYAMWSYKIFRSERFDLLGNSLAILTGMASLSRSRSILAWIEAECRALKEQNKLAVDLCPNLFPYIQPEDPDWQPRYDEFNRPGDYHNGGIWPFIAGFHIAALVAAGRMRMASRKLIALTELIKQKTHPKIEYGFNEWHNAFTGSPCGQDWQSWSAAMYIYAVECVKTGSTPFFDRIRIASGWKDVEKWLQRSIQHAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG1</accession>
    <name>A0A1U9NPG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hef nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02882"/>
    <dbReference type="EnsemblBacteria" id="AQT69687">
        <property type="protein sequence ID" value="AQT69687"/>
        <property type="gene ID" value="STSP2_02882"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02882"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="400" mass="42044" checksum="D593E3BCF7BF82AF" modified="2017-06-07" version="1">MNHSEGVENWLRLVRADGVGPKTFIRLRKHFGTVEDVLGASVHQLTKVEGVGPKTANAIRGSIDNFNAGKELELADKLGVTVITIDDARYPMALKETYDPPPVLYVKGEFARSDSLAVAIVGSRGCSIYGKEQAERFAHVLASSGFTIVSGLARGIDTAAHRGALAAGGRTIAVQGCGLGNVFPPENRKLFELICGRASDGNKKTYVGDANGPGGGNGAVISELPLGFEPLSQNFPARNRIIAGLVMGVIVIEAAARSGALITAKQALTNNREVMAVPGRIDSPRSKGSNGLIKEGARLVDSVEDVMETLGYVGEGLKGHVSACETKTKGKVETPLFDAARLNLSDGEKAVLGSFDGEPVHVEEVIRACGRGAGEVNSALISLRLKGLVKQLPGNVFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ9</accession>
    <name>A0A1U9NPJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsH</name>
        <name evidence="6" type="ORF">STSP2_03037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03037"/>
    <dbReference type="EnsemblBacteria" id="AQT69839">
        <property type="protein sequence ID" value="AQT69839"/>
        <property type="gene ID" value="STSP2_03037"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03037"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14365" checksum="0A2866525063CABD" modified="2017-06-07" version="1">MSLQDPIADMLTRIRNGGRAEMSQVMIRSSKSCQGVAEVLKDEGYIEDYDVIDDGKQGLIRIKLRYTLAGDPVITELQRVSKPGCRIYRGADELPEVLGGLGVSIISTSKGIMSDKNCRKDNVGGEVICTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS2</accession>
    <name>A0A1U9NPS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cph1_11</name>
        <name evidence="7" type="ORF">STSP2_03109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69909">
        <property type="protein sequence ID" value="AQT69909"/>
        <property type="gene ID" value="STSP2_03109"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03109"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="344"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="586" mass="65169" checksum="F567FD96084D2A94" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS3</accession>
    <name>A0A1U9NPS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane transcriptional regulator (Anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69744">
        <property type="protein sequence ID" value="AQT69744"/>
        <property type="gene ID" value="STSP2_02941"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02941"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="37677" checksum="42D9D48B94A05ADE" modified="2017-06-07" version="1">MREFDPKIEEMLSGYIDGELSRREHAEVQRLIQNDPDAASYVARLRKQKLLLNSMPVSDAPATTYDDVRAALEREFILDDTAHTTGEKAGRRHLLVRRFATAAIILVMLGGLTAIIMDIVMPEGGSQPLISNDFSIPEPVAMRDEPSAVAMRSRAAAPEAKAMAVAPEASPFVVRLDLATGEPISVNNFVQQQVFNHDLLENTMPTREEGRTVYKITAGVDRLKGFVGELGQAWPKAVSTKLTLVDPAASETDIFVEDADFRQVMQVVSQDDPQKRVELARVFASGGGLEGSMIASAEADVQGDMPDPGRPELASGDGRQLAAEDDPDAEQAVLILTVLKAGEGQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ25</accession>
    <name>A0A1U9NQ25_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69925">
        <property type="protein sequence ID" value="AQT69925"/>
        <property type="gene ID" value="STSP2_03125"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="531" mass="59697" checksum="A85398A46FD27B42" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ91</accession>
    <name>A0A1U9NQ91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein, rSAM/lipoprotein system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69985">
        <property type="protein sequence ID" value="AQT69985"/>
        <property type="gene ID" value="STSP2_03186"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03186"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="459" mass="51571" checksum="B374C67E832CC2BE" modified="2017-06-07" version="1">MSKLSNDEKGEFFKFRDYVRLAPYHSSTDVSKKVYVDIHNNNAHFEITNYYGHELQIEIGDFSHTIDIDEDDLSDVVINIPTPESFETRKVTFEFVPASPSQPIPDSGKFKVTYKKLPSARYAHSETLDIKTGTAQIKIPTPNRISWQPTKDTNFFFYRDSAKINSASSTIQTIKCYPAGAIFGKFKNTSPNQTRANLGIHVIERSPALPDNRHQTPIVNLNGSVGSIDLRTEGSYYIGPVPLDGEYGITVTVGNYYWLTDPIKLTPKRSICEYDITIPQNAVDLKGTLLDTRRNPITDATISLHIDAPFGGRTHSYGDTIETDQKGRFTIPSVNPDPKLEYSITFTAPGYVKTKHELTPTAHNKLTLEPALTVTGTVIDKKTGKPKPNIRINFWPTTGRDANLKLFEVTTDSNGRFTASQFANTTYNYRLEKDYSYSSKNTGKINPAKTPNTKLYWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE3</accession>
    <name>A0A1U9NQE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">STSP2_03028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03028"/>
    <dbReference type="EnsemblBacteria" id="AQT69830">
        <property type="protein sequence ID" value="AQT69830"/>
        <property type="gene ID" value="STSP2_03028"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03028"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14567" checksum="2FCFDD4C0ABD1CB3" modified="2017-06-07" version="1">MPRIVGVDVPNDKPLWVALTYIHGVGKHIADVIIKEAKVDREMRANKLTEDEVSRIAQIIQNNHVVEGQLRRRVAQNIGRLRDIRCYRGVRHQRGLPVRGQMTQSNARTRKGKKKTVAGKRSVKEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL2</accession>
    <name>A0A1U9NQL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="4">IMP dehydrogenase</shortName>
            <shortName evidence="4">IMPD</shortName>
            <shortName evidence="4">IMPDH</shortName>
            <ecNumber evidence="4">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 11" type="primary">guaB</name>
        <name evidence="11" type="ORF">STSP2_03429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 9">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03429"/>
    <dbReference type="EnsemblBacteria" id="AQT70223">
        <property type="protein sequence ID" value="AQT70223"/>
        <property type="gene ID" value="STSP2_03429"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03429"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="4">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="4 5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="490" mass="52724" checksum="7EBAAFE2313F1B3E" modified="2017-06-07" version="1">MRGDKIVAEGITFDDVLLIPARSDFVPSEADTSTQLTKNVRINIPMISAAMDTVTESSLAIAIAQEGGIGIIHKNLPVELQQREVAKVKRSENGIIQDPVTLSPADTVSRAKQVMDEQNVSGIPIITENRKLAGILTRRDLRFLTDDSAKIDTVMTKNNLVTASADTDLEQAKELLRRHKVEKLLLVNDKNELAGLITMRDVYRVEQYPLSVRDDRGRLRVGAAVGVKNFDRIEALIEAEADVIVVDTAHGHSENVIETVKWTKKNYDIDVIAGNIATKQAAKDLLEAGADAVKVGIGPGAICTTRVISGVGVPQISAVMDVVEVAKQYGAPVIADGGIRNSGDITKAIASGASSVMLGSLFAGLAESPGQTVIYKGRQFKEYRGMGSLGAMVKGSADRYGQKSDTGKEKLVPEGVEGRVPYKGPLSTFLYQLVGGLRAGMGYCGTRTIPELQDRAQFVKVSAATIHESHPHDIMITKESPNYSAAEYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY1</accession>
    <name>A0A1U9NQY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photo-lyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03402"/>
    <dbReference type="EnsemblBacteria" id="AQT70197">
        <property type="protein sequence ID" value="AQT70197"/>
        <property type="gene ID" value="STSP2_03402"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03402"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_7" evidence="1">
        <location>
            <begin position="297"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="486" mass="56301" checksum="23805D767C724F60" modified="2017-06-07" version="1">MAAAIVLPNQLFEDTEAIEKAEKVYLLEEERYFRDFAFHKKKLLLHRASMKAYEAFLRGKGFAVEYRDIGKGANVEDVLRSAGEDEFFTYDPVDQQLRGSMEKTAGKAGVKLHFARSLLFINGTDELRDFFGDSRDHYSMAGFYSHQRKKMGVLVKDGKPVGGKWSFDPENREKLPANIELPNVRKAKANDYVKEAADYVNKRFGGNPGETDGFVFPVTHRAAGTWLKHFLEDRLADFGRYEDSIARDEVFIFHSALSPMINAGLITPGEVVGATLNHADDHKIPLNSLEGFIRQIIGWREFMRAVYELEPERERDNFFDFSNALPDKLYNGRTGVDPVDTVIARVFENAYCHHIERLMVIDNFMLLCEIRPDEVYRWFMEMFIDAYDWVMVPNVFGMSQYADGGLITTKPYISSSNYIRKMSDFDKGSWCDIWDGLYWRFINRHRKVFANNPRMKVMTKQLDRMGKDKLKKRIEPAEEFLKELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ2</accession>
    <name>A0A1U9NQZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70148">
        <property type="protein sequence ID" value="AQT70148"/>
        <property type="gene ID" value="STSP2_03352"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03352"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011464">
        <property type="entry name" value="DUF1570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07607">
        <property type="entry name" value="DUF1570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012437188" description="DUF1570 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1570" evidence="2">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="37502" checksum="5A20AEDDE6CC5EDF" modified="2017-06-07" version="1" precursor="true">MRKNFTRNITLLLVLAFAAVFSFSPEASAKSGDQQLPSRLNGELGKRFAKLETRNFMVVHDSEPDEAARMASLLELLNSQFRDLFKKKGFELRKPSEELTWVSFEDLEDFENYAQKIDRVNLGGIKGYYSSRTNRVAVVKSSFDTSEIAKEDGDRFGSENSSIMAMAAEGDESLTKIQHEAAHQLAFNSGLQKRHVMYPLWYSEGLATYLENGYYNKDNEIRRKRLVELFKEGRLRRLDEFVTEVGVKGDNDEAKDLYAQAWGFFKFMMERKPELLKAYTARLYETEPGWRSEFSLYQELAQSAGSFEKLNAEWLDFVQELTSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR01</accession>
    <name>A0A1U9NR01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriophage protein gp37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69946">
        <property type="protein sequence ID" value="AQT69946"/>
        <property type="gene ID" value="STSP2_03146"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03146"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="38019" checksum="744AD5F536248953" modified="2017-06-07" version="1">MTKSKIEWTDQTWNPVVGCSRISEGCQNCYAERMAGRLANMNVPQYKQVVLFEDIANSRLSPEIKVTGWNGATAFVESALQKPLHWKKPRMIFVCSMGDLFHESVPFEWIDKVFAVMDLCPQHTFQVLTKRAARMREYFKSVKELPVGSPRDMAIFDGWRAVYGTKLNERLWPLPNVWLGVTAENQTRADERIPELLRCPAVVRFVSVEPMLGAVVMPEDGTACEFCGRNYESVTVDCGDWCEEFCAKCRDYDPDAVSTIITNHLGDGQSHINWVICGGESGPGARPLHPNWVRGLRDQCSEAGVPFLFKQWGGANKKKAGRLLDGVLHDEFPEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR37</accession>
    <name>A0A1U9NR37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69986">
        <property type="protein sequence ID" value="AQT69986"/>
        <property type="gene ID" value="STSP2_03187"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03187"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="254" mass="28840" checksum="59BBD0473F73B75B" modified="2017-06-07" version="1">MEISPYEDNRAWPAIDSDGKFSFSTRLKKFYILARPRKDYAITFFGPYKFAPGQTVTDLTLKLKRGFTSSVKFLDQNGRPIPNVQLTGGFPEPPDYSSWRHTIKSESDEQGVAAIQHTTDSPANLTCEAPGYIKDSRHKIDLSPDKPYTWQLNPAPTTQITVLSKKTGQPIPDAAVLLYGDEYQQMGNYYIDRPKWTTNETGLFELKTLAPGEQYRVLLYHPDYQRRYVDITAGDKVTAKLNDFQSITGKLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR69</accession>
    <name>A0A1U9NR69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rsmH_1</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="8" type="ORF">STSP2_03324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03324"/>
    <dbReference type="EnsemblBacteria" id="AQT70120">
        <property type="protein sequence ID" value="AQT70120"/>
        <property type="gene ID" value="STSP2_03324"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03324"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33702" checksum="68ABA21CF7E4BAD3" modified="2017-06-07" version="1">MSDKERSTEHIPVLAGILAEQITVPTDGVMVDATLGHGGHSSLFGSKMSPGGTIIGLDVDEKSLTRAQLELSDLECRVVLIRENFAQIEEILAEQGVEGADFILADLGFCSAQLMDPDRGMSFQENARLDMRLDDRLPTTAADIVNRTDEKDLADIIYRYGEERASRRIARFIVERRKAGPISTTGQLAAIICKALNQPPRGRRFKIHPATRTFQALRIAVNDELGNLEKLLNNAPKVLKKHGKIAIISFHSLEDRIVKNDFKAKADQGVYRIVNKKPLTADRAEIRDNPRSRSAKLRIAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR78</accession>
    <name>A0A1U9NR78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03334"/>
    <dbReference type="EnsemblBacteria" id="AQT70130">
        <property type="protein sequence ID" value="AQT70130"/>
        <property type="gene ID" value="STSP2_03334"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03334"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31084" checksum="09AFE9E8DD86EA2E" modified="2017-06-07" version="1">MFGVIGVIAFLTALGLSLVITRVATVALTMTGLSQQAARFQARSAFTGTGFTTSEAEQVVNHPVRRQIIMLLMVVRSAGFVTIIISLILSFSGPEAEGRRLLLLFWILGGVAVLWLLAVSKLMDKYLEIAIQKLLTKWTDLDTRDYASLLRLSGDYSVNELKMKSDDWLVGKQLKDCRLRNEGVTILGILRADGTYVGVPYPDTEIYEGDTLILYGRSDNLRELDTRPSSPSGDAAHEEAVNTQNRKKQEQDQQEAKSKKAVQAQKELDEQKDDQSANMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR85</accession>
    <name>A0A1U9NR85_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70036.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
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        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="28942" checksum="7BBE359C9E1B2866" modified="2017-06-07" version="1">MHNKKAFTLIELLVVISIIALLLAIMMPALGKVKTMAKRVYCANNIRSHSLYLKLYATDNDGRYHSHGDHSPEYARSNGSNDSLYHAMIPYIDDLDVMLCPVIRSIRSGDSIFKNPEYLHENGAYGGWGSVDLDAGQDPANITSPYMWLANYTYFGEEPKYSFRDDEGNMVNNPVHWPKNDGEATSRTPIFAHRVSNAAGGSGHFWDLSHGGNLVEMDTKFNVFSTATDNPLGYGDGSVTYNKKSEMEPRANAGAAGIIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRF5</accession>
    <name>A0A1U9NRF5_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Glycosyl transferases group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70200">
        <property type="protein sequence ID" value="AQT70200"/>
        <property type="gene ID" value="STSP2_03405"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03405"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022701">
        <property type="entry name" value="GlycosylTrfase_1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12038">
        <property type="entry name" value="DUF3524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3524" evidence="3">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="180"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="374" mass="43152" checksum="1DAAE28173942025" modified="2017-06-07" version="1">MRILALESYYGGSHKAFLDGWISRSRHDWTLLTLPPSKWKWRMRHSAITFAERVNALAESGGGWDAIFCSDMLNLAEFVGLLRPELQRLPRIAYFHENQLTYPVRFESERDYNYVMTNATTALCADAVWFNTHFHRDEFIDEMRKFMKRMPDEKPIKPLDAIPPKSQVKTPGIGVPSPVKNERKPGPLRILWAARWEHDKNPEDFFAAMTKLKKRGTDFRLSVIGEQFRDMPEVFEHAKTEFADRIDRWGYQPSRGEYIEALHEADVVVSTADHEFFGISMVEAIACGAYPVLPDRLAYPEVVSTIETFGQDDFLYDGKVASLVAALDRLAWRIKEDNLWLGNPHRGITAMQRFAWDKRATAMDDAVDEMISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP3</accession>
    <name>A0A1U9NGP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">fliP</name>
        <name evidence="14" type="ORF">STSP2_00042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00042"/>
    <dbReference type="EnsemblBacteria" id="AQT66904">
        <property type="protein sequence ID" value="AQT66904"/>
        <property type="gene ID" value="STSP2_00042"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00042"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341539" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29548" checksum="D43AA3D1BEF29407" modified="2017-06-07" version="1" precursor="true">MAGKMRFLLVGMLLAAVLVPFAGAAEGDEAGQSNVTNGTMPSVPQVLDVIDKATAAENLEEDQAWSGPIKMVIVFAVLAILPSLLIMMTSFTRIIIVLSFVRRALSTQNIPPTIAIIGLALFLTLFTMAPTFSQVNEKAIQPYLNEDMEFADAMTLTGESMKDFMIRQTRKNDLKLFVQMSGIEPPESPEDVAMHVAIPAFIISEFRTAFEIGCLLFIPFLLIDLVTASILLSAGMMMLPPAMISLPFKLILFILVDGWGLLAKSLSLSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU8</accession>
    <name>A0A1U9NGU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pheromone autoinducer 2 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00116"/>
    <dbReference type="EnsemblBacteria" id="AQT66978">
        <property type="protein sequence ID" value="AQT66978"/>
        <property type="gene ID" value="STSP2_00116"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00116"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="40472" checksum="77EE7A362D922A51" modified="2017-06-07" version="1">MADQRNRSDACRFSGPNSTFTAIALFALLVLAVFFMWLLRGLLMPVFIALLLAYVFHPLISWLDKHWSWPAWLSVVALILLTAAIFAGFTVWLLPVAINQTSNFLQNLPDYTERVISPITEEFQLGDEVRNQIEKYSQDPKKLLPFIVKGTMRSLDVLGNFFASSTYVLMYITLMLVFFVIFSMHLGPFAQWFTQFLPASKRDEAMTALNKINDAAYAFLRTRLLVALILGSMFSIGWAIAGVPYWFLLGVISGLLSIIPYAAGIGWIAAVLLNVLEAQNGIAGAIVWPTVVYGVAQMLEGWLLTPYLQGEKLNIHPGVVLFAVLAGGTLAGLLGMLLAIPIVAAAQIIFTDHIKPRMLEWAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH18</accession>
    <name>A0A1U9NH18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cph1_2</name>
        <name evidence="4" type="ORF">STSP2_00173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00173"/>
    <dbReference type="EnsemblBacteria" id="AQT67034">
        <property type="protein sequence ID" value="AQT67034"/>
        <property type="gene ID" value="STSP2_00173"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00173"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="338"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="509"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="585"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="638"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="714"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="809"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1016" mass="116249" checksum="CCC095C58C98D224" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH55</accession>
    <name>A0A1U9NH55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chromosome-partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">parB_1</name>
        <name evidence="5" type="ORF">STSP2_00406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67263">
        <property type="protein sequence ID" value="AQT67263"/>
        <property type="gene ID" value="STSP2_00406"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00406"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34939" checksum="FAEE98392FD94EA7" modified="2017-06-07" version="1">MAKKAPQKRLGRGLDSLLGGPVSTTKQQKSNPAVGPITPAEPDKPAGESVQKVSLGRIKANPYQPRTVWDEEQLAELASSIKANGVIQPILLRKNNGHFELIAGERRLRASQMAELEEIPAIVRDVTDEEMLEIALVENIHRSDLNPIERAHAYQRYIASFNLTQSQAAERLGENRSVIANHLRLLDLPKEIHEMLVNGQLSMGHARAILSLPTDELRRKLANRALAGRLSVREVERLVRKHLEGDKPKPEKSEKPAHITDLEKQLRSVLGTKVSIKARKKGERGKITIDFYSLDEFDRLTEILGLSRDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH68</accession>
    <name>A0A1U9NH68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_1</name>
        <name evidence="8" type="ORF">STSP2_00238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67098">
        <property type="protein sequence ID" value="AQT67098"/>
        <property type="gene ID" value="STSP2_00238"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00238"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="506" mass="54543" checksum="EC076C9EE4D9FF80" modified="2017-06-07" version="1">MAVFDYVIFGLYMCAVLGVGFYHFRRNTDRDDYYVGGRAIKPHHVGLSIVATDVGGGFSIGLGGVGFMMGLAGSWLLFTGLVGAWLSAVLIIPKVKKLDAKHSMMTYPDFLRRRYGPTVALLAALISGIGYLGFTGGQILAGAKLAAGTIFTEAPFGMDPINFSLYVIAVITVLYTVVGGLKAVIYTDTVQWLILLGGLILVTVPATFMQIGGWGALRAELPKEYFNLTNIDSSTFINWMVTIIPIWLIAMTLYQRMYACKDEKDAKKAWYIAGIFEYPIMAFTGVILGMCARVVFPEAEPEMAMPMLIKDVLPIGVTGIVIAAYFSAIMSTADSCLMASSGNFVNDIIERYFCPSISDKGLMRLSQVVTLVIGATAVILAAQSEQVLDAIMTAYGFMVSGLFVPTLGAYFWKRSTGLAAGTGMLGGGITYLLLEFGAIEKLAQRFEWSSWLSLSEKMTALDLDPTCYGIAVSAVLFVVLSLFGPQRQVELSDSDSEDGDAGTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC6</accession>
    <name>A0A1U9NHC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67010">
        <property type="protein sequence ID" value="AQT67010"/>
        <property type="gene ID" value="STSP2_00148"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00148"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9327" checksum="3B38A28471F90E06" modified="2017-06-07" version="1">MDTQVVSFKALRKTKAEEPKTDKFDFQPKNKFFTCPFINAIHAISGYNNTFECETTSCSIIAEKGNVTRSSGYRFFRRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH3</accession>
    <name>A0A1U9NHH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease R</fullName>
            <shortName evidence="5">RNase R</shortName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rnr</name>
        <name evidence="8" type="ORF">STSP2_00526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00526"/>
    <dbReference type="EnsemblBacteria" id="AQT67382">
        <property type="protein sequence ID" value="AQT67382"/>
        <property type="gene ID" value="STSP2_00526"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00526"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="625"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="741" mass="82773" checksum="8B1DA480222C48F5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHR7</accession>
    <name>A0A1U9NHR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00441"/>
    <dbReference type="EnsemblBacteria" id="AQT67298">
        <property type="protein sequence ID" value="AQT67298"/>
        <property type="gene ID" value="STSP2_00441"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00441"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="28426" checksum="2C8FB2A48B4E6F64" modified="2017-06-07" version="1">MINYDMHIHTEYCGHAPGMTVPVILERADELGLETICITDHIFVEEDLELIDKIRDEVERTTSDCTVLVGAEVDVDPDHFDGTLITDRISQLDYVLASLHYVPGVGEFAETPDDNPLEPEVLLERWRTTLLGLAADKHVHAIGHPGRMIGSSLDLDSHYEDILAIFEEVAPVSAKNNTAWELNELTAYRLSDYYRQQWYRIFEIGHAAGVKLIYGSDAHAPEDIGYYEEIKALLAKLPEDALARPTDLLKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU7</accession>
    <name>A0A1U9NHU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaD</name>
        <name evidence="2" type="ORF">STSP2_00226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.19" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00226"/>
    <dbReference type="EnsemblBacteria" id="AQT67086">
        <property type="protein sequence ID" value="AQT67086"/>
        <property type="gene ID" value="STSP2_00226"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00226"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="16"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28257" checksum="57D31C6418AB5882" modified="2017-06-07" version="1">MNQHEKSNPAVSNALDDIASLARLLAEKGWAQGPGGNISYNLGPITADPLTPTAAPVKLGRSFTALAENLIVITATGRTMRDIAANPSDNVCIIRLTPDPDAYELLSPSSGARPTSELPSHLAIHQLYTQKGLKSTAVVHTHPNELTALTHCPQLQNTESLTSLLSSMHTEVIMDIPHGIAFVPYEMPASQAVADATLSALTQTPVCVWEKHGALAVAPTPHKSFDLIDIANKAATIYLLCKNAGIEPQGLTEAQVRQIKDKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY0</accession>
    <name>A0A1U9NHY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00679"/>
    <dbReference type="EnsemblBacteria" id="AQT67531">
        <property type="protein sequence ID" value="AQT67531"/>
        <property type="gene ID" value="STSP2_00679"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00679"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888753" description="Glug domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="5">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="750" mass="79334" checksum="C872B429B0992EB8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY6</accession>
    <name>A0A1U9NHY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67358">
        <property type="protein sequence ID" value="AQT67358"/>
        <property type="gene ID" value="STSP2_00502"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00502"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11383" checksum="A8E598FFA38759AA" modified="2017-06-07" version="1">MTQDKFCSNCPNKHDCKSIYEAMGNTKGESVVLKVIVAFLLPIIIFIAALMLSQELLADKLDGQKTEAVVPALIALGATLTWITVIYVINTILARRSGRSSSQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ4</accession>
    <name>A0A1U9NHZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaX_2</name>
        <name evidence="6" type="ORF">STSP2_00710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00710"/>
    <dbReference type="EnsemblBacteria" id="AQT67562">
        <property type="protein sequence ID" value="AQT67562"/>
        <property type="gene ID" value="STSP2_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00710"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNApol3-delta_C" evidence="5">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="372" mass="41904" checksum="1DDB81566A117B18" modified="2017-06-07" version="1">MSLKDIFCQDKPISTLQNAYAAGRLAHGYIFAGPDGVGRYKTAREWAKVLLCQEPVSGQTEDGKFYDSCGVCESCKLFEGDGHPDFHHVYKELVRFTEKGKNKKTPVQMPIDVIREFLIEKVAAKPKVSESTVYVLSESEKLNAESQNALLKVLEEPPGHCSIILLCSRLEKLLPTTLSRCQVLRFGDIDEQKIVERLAANGVEQTEATFWARFSDGSIGNAMEWAALELKNDSCYKIKQILVKGLARHQLSRSLDFAEWLSNSSKSISAAWADVDENTSKTDLNRRAQKGLIRMMIAFFKDVMRMQAGLEDNLVNSDQMQEVKTMASRIDPDQAAKNIEKACENMIWVEKNVNERLIFEDLLLNYAGCGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI02</accession>
    <name>A0A1U9NI02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">STSP2_00711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00711"/>
    <dbReference type="EnsemblBacteria" id="AQT67563">
        <property type="protein sequence ID" value="AQT67563"/>
        <property type="gene ID" value="STSP2_00711"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00711"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24318" checksum="9CD23B3F2721FF00" modified="2017-06-07" version="1">MCLCGHLKDVEVTNRFDGKFIVLDGPDGCGKSTQAELLAEHIRSNGSEVVGFRDPGTTVIGEKIREILLDVDHAGMADNVEVLLYMAARAQLWKEKIGPALREGKCVVMDRWISSTCAYQGWAGGFGVKKVIKLGEDCLERVWPDVTVVLDVDLETAAGRMNRELDRMEQKGQAYHMKVREGFLELAKMSDTVEVADASRTVEQVQADVVIAVEKHLGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI42</accession>
    <name>A0A1U9NI42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67394">
        <property type="protein sequence ID" value="AQT67394"/>
        <property type="gene ID" value="STSP2_00538"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00538"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="29034" checksum="5F32730BE28C41D9" modified="2017-06-07" version="1">MDTYLYLSVIPESLVMSMLGPEEFGTYLAVGTQKRSKEHAIFFELDKDFKSDYFDLDAAREKCKPHDNGEPKHSVYVSIYRVLEHIPLDAVKDIYLVTNDGRVLKLPQASVPSFDAKYHLYQELAPVHPLIASNLHPPDFRKFITDPSTGFSVPKICFVDLRLGDLAEDCNGSVRDLPYKNIEHLRDCLANLGKDKNTKTVDRIFPQHVPYRMVASGFYLGDQQNMLFYPFPTEEQFRDKYHDWWRSATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI51</accession>
    <name>A0A1U9NI51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein TcrX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tcrX</name>
        <name evidence="3" type="ORF">STSP2_00548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67404">
        <property type="protein sequence ID" value="AQT67404"/>
        <property type="gene ID" value="STSP2_00548"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00548"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14061" checksum="BD947C9B1528D90F" modified="2017-06-07" version="1">MAQRSILVVDDNEEFTELAMMALSVGPFDVLEANSGPEALKIAKKHRPDAILLDVSMPDMDGLKVLAKLKKNRKTKEIPVIMLTGKSKIEDLDAAFELGANGYITKPIEFADMVKIVEYKLEKAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID4</accession>
    <name>A0A1U9NID4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin N-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67508">
        <property type="protein sequence ID" value="AQT67508"/>
        <property type="gene ID" value="STSP2_00656"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00656"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20716" checksum="EC8026A4B4EC1C12" modified="2017-06-07" version="1">MNYDELEKLAGQKEDENWAFRSFLKFYDDLTDQQIDRLVHELTDSVAADIDCTKCGRCCKQLKPTLTTNDQKRLAKALNITSSQLQQSYLEYVQDEESNCWQMKKTSCPFLKNRKCIAYESRPQDCRNYPYLKKPDFTMRTIAMLDRTRTCPIVFEVIEQLKEHLAFDAGNSAGNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH1</accession>
    <name>A0A1U9NIH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00878"/>
    <dbReference type="EnsemblBacteria" id="AQT67729">
        <property type="protein sequence ID" value="AQT67729"/>
        <property type="gene ID" value="STSP2_00878"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00878"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888758" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1463" mass="159790" checksum="3DAA0F3B6ED4E0CF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP3</accession>
    <name>A0A1U9NIP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67376">
        <property type="protein sequence ID" value="AQT67376"/>
        <property type="gene ID" value="STSP2_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00520"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12000" checksum="C1602E2F7DE65B79" modified="2017-06-07" version="1">MLTQLLETLQNLAAPADKQIEYLDGMQVQELVWEFMDASDNLDILVEDGLLTTETYQAIKLLKAKVARLNNSQNQCSHEALKTSPDWQQVRQLAKQILNRLDDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS5</accession>
    <name>A0A1U9NIS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67833">
        <property type="protein sequence ID" value="AQT67833"/>
        <property type="gene ID" value="STSP2_00984"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00984"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211443" evidence="1">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="246" mass="28034" checksum="A0F003FB9A142245" modified="2017-06-07" version="1" precursor="true">MNKINVLVMLSLLHSLSLMCGCTTNELGSKVNLVANAEGRKDFPIISVFVSLTANKTVTSDNLSAGSEALVPQIITCIWPDGTMVYSSNRIEGGSPYYKAALSQKEISSFLNKLETTDFWNADQRQSWYGFDSDRSIIVIIDQSKTKYLSSWHELEEQNQNLVVTDRGVEPLQGRSRKEVMSSCSDEYAQFIAKWKFVRYELEKLIPDEHTNLAENMKFEYAYLSVREIESTAHVNKFFRKQSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT6</accession>
    <name>A0A1U9NIT6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67843">
        <property type="protein sequence ID" value="AQT67843"/>
        <property type="gene ID" value="STSP2_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00995"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="46961" checksum="5BF54199BB2F39AB" modified="2017-06-07" version="1">MQKNESDRSVADLNKAIKIDESQIQNHLGEMVRSTVEQTLNNMLDAEADQLCNAKRYERTSERVNSRAGHYKRNLHTRSGEVKVKMPKLRRAKFESAIIERYRRREASVEEALMEMYLAGVSVRRVEDITEALWGMRVSAGTVSDLNQKMYERIDEWRNRRIEGEYPYVYLDGICLKRSWGGEVRNVSVLVAIGVGKDGYRDILGVVEGGKEDRDGWSGFLRSLKQRGLKGVQLVVSDKCLGLVESLGEFFPDARWQRCTVHFYRNVFSVVPRGKMQEVSAMLKAIHAQEDLAEAKKKAHAVADKLDGMKLRRAAQRVREGAQETLSYYHFPRKHWRQIRTNNPLERIMREIRRRSRVVGCFPDGNSALMLAAARLRHIAGTKWGTRRYMNMDRLREMQNEAIAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ3</accession>
    <name>A0A1U9NIZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcpC_1</name>
        <name evidence="2" type="ORF">STSP2_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67694">
        <property type="protein sequence ID" value="AQT67694"/>
        <property type="gene ID" value="STSP2_00842"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00842"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012662670" evidence="1">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="456" mass="51722" checksum="15E957A0D34D7360" modified="2017-06-07" version="1">MRKVIIILTLISTSYLFAGEQTAKEIAEAARDGSSESLAQLEEMADGGNADAQYELGRMYHDGAGVRLDNGLAKKWFERSVARGNPKALYKLAVMYKYGRGTVRDLDKAQEYFKKAFAGIEEPANQGDAEAQYLFGNMYYHGNGTAVDNRKAYDWFSRAAKVGNYTAQYALGYMYLYGEGVQQDDIKSTKWFSKALPALRKAAEHGDIYAQLDLGNMLYSGYGVPEDETRAAEWYSKAAERGFADAQYELAVMYGAGRGVKADQCKEDELLEKAAEQGHLKAQLRLAKICDWRRQYEQAFKWYRRAAEQVHSGAMYELASMYDAGRGVEQSKEKAAEWCERAAEHGYIQAQSDMGYLYEHGEGVEQDYSKAFEWYCKASERGYPIAQLRLSYLYSKGLGVSVGRVKAYKWCVLSGRDASILDDARKQKELLEKTMSEDEIKEAMNLAEQWYRDYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ05</accession>
    <name>A0A1U9NJ05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EcnA/EcnB lipoprotein family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000189674">
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            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="AQT67931.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8482" checksum="A72C9CB41001C28C" modified="2017-06-07" version="1">MIKKLTKHGNSYAMVIDKPILDLLQATPETSFEIISDGRSLVLTPVRSPEQEKKFHDAVSMIHERFGNAMKKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
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    <name>A0A1U9NJ75_9BACT</name>
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        </submittedName>
    </protein>
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    </gene>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
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        <location>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
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            <end position="131"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AQT67979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16343" checksum="4A751145687042B4" modified="2017-06-07" version="1">MYVREIMTMGVETIGSDATVAEAAKKMKSLGIGSIPVVQDNKIIGIISGQDVIFRCVAEDRDPRESPVNEFMTSELTCISQDERIEEAAKLMEDKHIHRLLVLDSSNNPVGVLSLSDVAVKSKDEHLAWEVLERISEPASPYRRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD1</accession>
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    <organism evidence="1 2">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AQT68021.1"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27436" checksum="7C14D2BFB3FF50F9" modified="2017-06-07" version="1">MEKLKLYFGNGTRSDKYHYNRMLYDGEEAFSFIRVKEHSSIKHGTVIKTFVDEQTDLSPFSFRQSPLAGVIGFCEEGPRSIEKIVGGAKGKVRVHGRQEMKGSQCHVVSIDSKYGYYKLWLDPEHGYNVVRAKFDLDAGDIDRLGKVMPKGTWARRTYAVEEFALIEDIWVPVAYRITDDSILPGGYYNKAKTSFKITSIELNPDHEKMGSFALDEVPDGSLAMISGQRREYVWRDGELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD5</accession>
    <name>A0A1U9NJD5_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Bacteriophage tail assembly protein</fullName>
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        <name evidence="1" type="ORF">STSP2_01087</name>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG7</accession>
    <name>A0A1U9NJG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">STSP2_01026</name>
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PSD1" evidence="2">
        <location>
            <begin position="275"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="538" mass="62260" checksum="89D9631E5B5FBFD1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH1</accession>
    <name>A0A1U9NJH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exopolysaccharide biosynthesis protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">STSP2_01040</name>
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    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT67888">
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        <property type="gene ID" value="STSP2_01040"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01040"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
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        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49363"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="599"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="658" mass="71066" checksum="966703BE8BE1CFDF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM4</accession>
    <name>A0A1U9NJM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67934">
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        <property type="gene ID" value="STSP2_01086"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01086"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6950" checksum="5C28B53BE3141C17" modified="2017-06-07" version="1">MSSNAARITAISPKKAAEILRKSGSKFANTETISADIKAGAPVNEDGTINIVEYAAWLVKEDGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN6</accession>
    <name>A0A1U9NJN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00839</name>
        <name evidence="4" type="ORF">STSP2_01179</name>
        <name evidence="5" type="ORF">STSP2_01249</name>
        <name evidence="6" type="ORF">STSP2_02018</name>
        <name evidence="7" type="ORF">STSP2_02979</name>
        <name evidence="8" type="ORF">STSP2_02981</name>
        <name evidence="9" type="ORF">STSP2_03255</name>
        <name evidence="10" type="ORF">STSP2_03269</name>
    </gene>
    <organism evidence="4 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT68025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67691">
        <property type="protein sequence ID" value="AQT67691"/>
        <property type="gene ID" value="STSP2_00839"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68025">
        <property type="protein sequence ID" value="AQT68025"/>
        <property type="gene ID" value="STSP2_01179"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68094">
        <property type="protein sequence ID" value="AQT68094"/>
        <property type="gene ID" value="STSP2_01249"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68842">
        <property type="protein sequence ID" value="AQT68842"/>
        <property type="gene ID" value="STSP2_02018"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69782">
        <property type="protein sequence ID" value="AQT69782"/>
        <property type="gene ID" value="STSP2_02979"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_02981"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT70053"/>
        <property type="gene ID" value="STSP2_03255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70067">
        <property type="protein sequence ID" value="AQT70067"/>
        <property type="gene ID" value="STSP2_03269"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00839"/>
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    <dbReference type="KEGG" id="alus:STSP2_02018"/>
    <dbReference type="KEGG" id="alus:STSP2_02979"/>
    <dbReference type="KEGG" id="alus:STSP2_02981"/>
    <dbReference type="KEGG" id="alus:STSP2_03255"/>
    <dbReference type="KEGG" id="alus:STSP2_03269"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="21306" checksum="6AB2AAE39510998E" modified="2017-06-07" version="1">MNQPASNGPTISFDEFGPLEIRPQPGRNYCHTDHPKRLPATYTRKHGVQHWLAFYDVHQKKLWGYVRPRKRHQEFLEVLKLTRKKYPANQRIHLILDNFSPHRKDKVLRYCRENNIHLIWTPTNASWLNPIECQFTHVKEFVIRGTNYQNHNELKIALNRYVAYRNKKNQQKLNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK56</accession>
    <name>A0A1U9NK56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH-type transcriptional regulator IscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscR_1</name>
        <name evidence="1" type="ORF">STSP2_01048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01048"/>
    <dbReference type="EnsemblBacteria" id="AQT67896">
        <property type="protein sequence ID" value="AQT67896"/>
        <property type="gene ID" value="STSP2_01048"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01048"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16545" checksum="B82E1E2E7F82A121" modified="2017-06-07" version="1">MAFELENFGRLPKKSEYALRSLYELAARAKAGPVKVRSIAESQKLPVRFLEVILAQLRQGGFVESRRGSGGGYLLARNANDISVGEVLQFMQGGAAVEVGPDKDVPGQAAFSDLWREAHDAVANVFEGTSLGDLVRNEEKRRSEYVGNYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK79</accession>
    <name>A0A1U9NK79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68225">
        <property type="protein sequence ID" value="AQT68225"/>
        <property type="gene ID" value="STSP2_01381"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01381"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3813" checksum="82C7DB45304591D7" modified="2017-06-07" version="1">MSVECYKGFNRFLNVFRCSIMTNYEESPNCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK91</accession>
    <name>A0A1U9NK91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type-1 restriction enzyme R protein</fullName>
            <ecNumber evidence="2">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hsdR_2</name>
        <name evidence="2" type="ORF">STSP2_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01383"/>
    <dbReference type="REBASE" id="190996">
        <property type="entry name" value="PbaBD1IIP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68227">
        <property type="protein sequence ID" value="AQT68227"/>
        <property type="gene ID" value="STSP2_01383"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01383"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="169"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="916" mass="104126" checksum="779E346416D5C401" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB4</accession>
    <name>A0A1U9NKB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68030">
        <property type="protein sequence ID" value="AQT68030"/>
        <property type="gene ID" value="STSP2_01184"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01184"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26293" checksum="9ACF20E16036A31F" modified="2017-06-07" version="1">MSKDPTKTRLYLLIGAIVAAVVAWNVWELYSSGVVGGVSLSNSDGNGREASAGAAEPSSEIEAGEVVEKEAAGGSAESSGNAQAVEQGSEPGVIAKSGRDFWKPFGDVKIKWEGNTIESVSVPEEIRAMDGEVVSLPAICVLTRKGMEKNENGCTVNNFLVVPPFGVVRCCKLTPVTRYEWTVIVDCSDEPWQIEGEIPNAQTMNVRGRFRIAEKHLNEGLFFIEDAEVKPTNEDLIGDEDICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB6</accession>
    <name>A0A1U9NKB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-3-amino-3,4, 6-trideoxy-alpha-D-glucopyranose</fullName>
            <ecNumber evidence="2">2.1.1.234</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">desVI</name>
        <name evidence="2" type="ORF">STSP2_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.234" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01533"/>
    <dbReference type="EnsemblBacteria" id="AQT68373">
        <property type="protein sequence ID" value="AQT68373"/>
        <property type="gene ID" value="STSP2_01533"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01533"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="26062" checksum="CBB4C43A772DA2AA" modified="2017-06-07" version="1">MKKISSTIRKIRQKLLGDPKYVPARYWKKRHAKFGFDMRGVGNKSYSDEQNRQDYAQAETIVLELCSEYVSNWSSLKVLDIGCGTGFYTEMLQRQGVKNYTGIDISDQLFPELRRRFPDYTFRKTDVTSEDLPDKSYNLVLMIDVTQHIVSEQGFARAMENVRSHLSSNGIFIVTSWLADQTHKRTYYELARSFDCYTEQFEGYKISQPVPFRDKYIFVVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB9</accession>
    <name>A0A1U9NKB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67966">
        <property type="protein sequence ID" value="AQT67966"/>
        <property type="gene ID" value="STSP2_01118"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01118"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7641" checksum="448D70EB3670C865" modified="2017-06-07" version="1">MTESYKPHEMYPPQRRAEVARILARAANRLHCKSGGLKLALKKRQELVKSSQTCLDVSGQMRIDVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF7</accession>
    <name>A0A1U9NKF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68413">
        <property type="protein sequence ID" value="AQT68413"/>
        <property type="gene ID" value="STSP2_01573"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01573"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="16338" checksum="33521585C0A6A475" modified="2017-06-07" version="1">MNLKPAIQDNVTDILVKIIEFTRRRDEVLRHNVLAVNDESFEPRDLDVDGFADLMAFAMSEHVSNNRLVFSDNQTIRFCGGGRFETEAVVDRQAKKLFENDISKYLKQQMKKISENMLNRKVAEELLRHKEQRQATVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG4</accession>
    <name>A0A1U9NKG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_01160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01160"/>
    <dbReference type="EnsemblBacteria" id="AQT68006">
        <property type="protein sequence ID" value="AQT68006"/>
        <property type="gene ID" value="STSP2_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01160"/>
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    </dbReference>
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        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="507"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="665" mass="73431" checksum="520B5C84EB99149C" modified="2017-06-07" version="1"> </sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <end position="25"/>
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        <source>
            <dbReference type="EMBL" id="AQT68086.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ3</accession>
    <name>A0A1U9NKQ3_9BACT</name>
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        </submittedName>
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        <name evidence="3" type="primary">nlhH</name>
        <name evidence="3" type="ORF">STSP2_01251</name>
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    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="248"/>
        </location>
    </feature>
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            <end position="322"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38883" checksum="DD4CEE0FBE2AAE4D" modified="2017-06-07" version="1" precursor="true">MKRHEIISILVIAMSAPWTSTGLADVSGSVRTSPNFKEGLTNVNHAWLDRIMFELSQGNLLEATNKPANDTATEGACDSKDASKSIVKLANVTYKKTVDINSNPVALKMYHRYQPKKVSEPLPAILLFFGGGWSSRNLGQMEEFCKYFAARGMICMAPDYRVSSVEGTSPYEAVNDAKSAVRWVRANASNLKIDPDRIIVGGGSAGGHIAACTEIITGYNEPGEDLSVSSKPNLLCLLNPVVDTTKNGYGSRRFTPETDKELSPFHHITPDVCPTIIFHGTDDTTVPFENVERFTQKMHDNSNTCKLVSFDGKAHGFFNHVNFRPDKDPADFKVCAEESFNFFIANDFGRGGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ9</accession>
    <name>A0A1U9NKQ9_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33341" checksum="154ED1A96D4E1B39" modified="2017-06-07" version="1">MDVLNTIAPVFLVILTGYILTKKRFLSDSLVKDLNRICFWIALPALLFGKIVGSTGNFTVVMETFLVVTAGMVACLLGGFVLARLLKVPFTSVGTFVQGTYRGNLAFVGLAVIIYSLADFTPEHAQQVETLAVYVLAPIVPIYNLVAVFLLVAFRQNDNRNAALKKIPVQLASNPLVIACAAGFLVQRFLPSPPLAIMRTLDVLGQMALPLALLGVGGALAHRKIAGRSLYAISASLLKTVLAPAVGLLLAHLMGLSQDEMRVALIFLACPTAISSHTMAERMGGDAQLSAAIVIISSLLSILSLSAILAMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS2</accession>
    <name>A0A1U9NKS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68533">
        <property type="protein sequence ID" value="AQT68533"/>
        <property type="gene ID" value="STSP2_01698"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01698"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24814" checksum="A6019DB6F6FD86A0" modified="2017-06-07" version="1">MRTASTICLCLLLAVIAIPNGGCTILGFLASPTWHEQKIPAEYRIKDQQDRKILVFVDEVSGANVGLTFRRSVAQTFENYLIGRTGVKSTNIVSRRGIDYLRQNRDDFSLMTPAEVGKELGAGLVLYVLIEDYELYGMTEESYYRGSLLSRSVLFDSDTGTIVWPDKKGEPVDAIVELDTNRDSAVQRLAAATARTITNRLFDCPRDEMKVSDIRDEAYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY5</accession>
    <name>A0A1U9NKY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01548"/>
    <dbReference type="EnsemblBacteria" id="AQT68388">
        <property type="protein sequence ID" value="AQT68388"/>
        <property type="gene ID" value="STSP2_01548"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01548"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14750" checksum="AD46C06C7BBC82CE" modified="2017-06-07" version="1">MPNRSGTDHTIFLLTVGALAWIIPGAGHFMIKEKRRGAIICVTILSTFAIGLFVGSIAVVNPNAGGLWYIGQMLVSPLVAMVGQMTASKGLVVYGRESDIGQIYTTVAGLLNLLCVISAVYMAHSGRGEIIGEEEEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ7</accession>
    <name>A0A1U9NKZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68186">
        <property type="protein sequence ID" value="AQT68186"/>
        <property type="gene ID" value="STSP2_01341"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01341"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012098005" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="664" mass="71430" checksum="F0815E88829D4949" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL17</accession>
    <name>A0A1U9NL17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA_1</name>
        <name evidence="6" type="ORF">STSP2_01799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01799"/>
    <dbReference type="EnsemblBacteria" id="AQT68631">
        <property type="protein sequence ID" value="AQT68631"/>
        <property type="gene ID" value="STSP2_01799"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01799"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="679" mass="73434" checksum="E5EDD4B4234F74BD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL23</accession>
    <name>A0A1U9NL23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68609">
        <property type="protein sequence ID" value="AQT68609"/>
        <property type="gene ID" value="STSP2_01777"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01777"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011984732" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21449" checksum="58E12D69DC020418" modified="2017-06-07" version="1" precursor="true">MRFTAGLVLSLILVSGAAAAPVAVDFDSEFGAYHLLGEIVSGECEGMVPGLGIKSAVYTDGESYLYLYQLQNNAGSGVKRVTFAPFSDVSLDTLVGYLQTHDLADFQEDGLAPVLAETGDHERVSPFAGFSFRSYGQGSALLPNEHSAVLFVKSDRRPTMIDANVLFNDGNATGEVYGAVPEPMTILFLASGALMLRRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL51</accession>
    <name>A0A1U9NL51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase (Bacterial type)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01469"/>
    <dbReference type="EnsemblBacteria" id="AQT68310">
        <property type="protein sequence ID" value="AQT68310"/>
        <property type="gene ID" value="STSP2_01469"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01469"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="606" mass="67061" checksum="2EC60B145257335B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL54</accession>
    <name>A0A1U9NL54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68555">
        <property type="protein sequence ID" value="AQT68555"/>
        <property type="gene ID" value="STSP2_01723"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01723"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16357" checksum="A361B707D1691F60" modified="2017-06-07" version="1">MFKLKFDIILMLPIFCLTLFGCNDSRDTVQPNDRLPAHLVGVWASEDAVMEGSALFEGVAVYLGADGVGAIVGGPPAIGCQIIAKFESSNDTILYEMTENGKTVEKGKLLYDPDHRTLTLIQDTCVVLTRRFDELDDNTLTDLGLEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL83</accession>
    <name>A0A1U9NL83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68488">
        <property type="protein sequence ID" value="AQT68488"/>
        <property type="gene ID" value="STSP2_01653"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01653"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31911" checksum="43F2C8CC3F4CD1C1" modified="2017-06-07" version="1">MTRKKCIQYTAPQNKAALSITTKKDRASGSCPPGCAVTHVSSPFVNIELIISYRTDTCLSLPELVPAAQQLSDILLTEHFFSDSNSLPKPTCRKGCSHCCKYLVGISPAEAYYLAELVETYPDARQRFLNNSSVILQACDQLAYIHESRFSHLEQDSKNSEFISNWYSELKLSCPLLENDVCKVYNHRPLVCREHLTTSQPQACRPDSPNEPEILPMPFSVAELLMNVCAELENSMPESILLPLSLPWSHANTTRKTQKWPVKTVLNVLINQLNRITQSQVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE2</accession>
    <name>A0A1U9NLE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01813"/>
    <dbReference type="EnsemblBacteria" id="AQT68645">
        <property type="protein sequence ID" value="AQT68645"/>
        <property type="gene ID" value="STSP2_01813"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01813"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="43036" checksum="D77D61C2A6FB6D88" modified="2017-06-07" version="1">MKKVMVITFHSVPNYGAVLQAYALCNVLRQIGFDVHLIDYQPKSISKGDSDSPLHKKFADFRKKHLPLTPQVFTNLNQLNGVDADVLVCGSDQIWNFAKSKARKNMDAFLLNFGPDSAIRISYAASTGGVGFPKEYHDKISECLASFQNISVRERTSLKDVGEVTDKSIDITVDPTVLCDDYPEADITCYELPEKYIVTYCLQASPVFLDAVHRVKTLYNLPVVNIGDTAAGLADKSLTSLGPDEWICLLRQSECVVTNSFHGTVFSIKVKKNFLSVPLLRKKKNKIYGLQEKLYRKGYRKAWCLPGNSIMRNRLFANWSSKNDRISSFLRLSGLNSRLYDYPDSIDFVGRPIDYDNVMQKIKYEKDESIRFLHKVLKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG6</accession>
    <name>A0A1U9NLG6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tuaD_1</name>
        <name evidence="12" type="ORF">STSP2_01495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01495"/>
    <dbReference type="EnsemblBacteria" id="AQT68336">
        <property type="protein sequence ID" value="AQT68336"/>
        <property type="gene ID" value="STSP2_01495"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01495"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="314"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="450" mass="48970" checksum="E3F36381ACA5FA0B" modified="2017-06-07" version="1">MKVSVVGVGYVGLVAAACLAEGGNHVVCVDNDQKKIDDLNQGVIPIYEPGLTEIVKKNVEAGRLIFTTDLSEGVAKSLLVFIGVGTPSADDGSADISAVLAVAKDVARCMDGYRIVVTKSTVPVGTHKKVSDIISSYTEHPFDYVSNPEFLKEGSAVDDFLKPDRVIIGTTNPAVMEIMKQLYAPFMRKKSRMIFMDPASAEMAKYAANAMLATRITFMNELSGLCDELGADIEMVRHGIGSDGRIGSSFLFAGLGYGGSCFPKDVRALSFMGDGCGCEMTLAKAVQAANYKQQDRFAERVIEYYKNRPETTLAAWGLAFKARTDDVRESPALRCVNKFIAAGIKVKAYDPEAMETAVADIDGKVEMGENAYDILNGCDGLVIMTDWQEFRSPAFDDIKDKLNKAVIFDGRNLYEPPFVAKQGIEYHSIGRVSVFPQGVQQETDSLRMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU2</accession>
    <name>A0A1U9NLU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="6">MTHase</shortName>
            <ecNumber evidence="2 6">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 6">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">treZ</name>
        <name evidence="11" type="ORF">STSP2_01620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 6">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="2 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01620"/>
    <dbReference type="EnsemblBacteria" id="AQT68456">
        <property type="protein sequence ID" value="AQT68456"/>
        <property type="gene ID" value="STSP2_01620"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01620"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="10">
        <location>
            <begin position="113"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="257"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="389"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="607" mass="70034" checksum="AE11C9091DB44AA3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU5</accession>
    <name>A0A1U9NLU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68704">
        <property type="protein sequence ID" value="AQT68704"/>
        <property type="gene ID" value="STSP2_01876"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01876"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22478" checksum="575490DACFCC60D8" modified="2017-06-07" version="1">MTSHTVLPSTRPKVFLGSVDNSGSSGTLDRNGSTRQESAQDGILAFCQTRTAINPDDLFVGIGFNNKERVFCEPVPVCRIDAIRSAVKSLRPRGGTRSAGLEAANYYADHYRKHGCKVSLIILTDGHISMSSKHMKIAESLKSRGVVIDTIGIGGQPRDVDEQLLKDIATTDPDGYIHYRFIDDSETLIRHYENLAAGLRIENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM48</accession>
    <name>A0A1U9NM48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type IV pilus biogenesis and competence protein PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pilQ_1</name>
        <name evidence="6" type="ORF">STSP2_02082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02082"/>
    <dbReference type="EnsemblBacteria" id="AQT68905">
        <property type="protein sequence ID" value="AQT68905"/>
        <property type="gene ID" value="STSP2_02082"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02082"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160467" evidence="4">
        <location>
            <begin position="33"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="5">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="595" mass="65370" checksum="A4F10F03F1F92748" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA3</accession>
    <name>A0A1U9NMA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="7">3.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sacA</name>
        <name evidence="7" type="ORF">STSP2_02114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68937">
        <property type="protein sequence ID" value="AQT68937"/>
        <property type="gene ID" value="STSP2_02114"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02114"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572546" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="6">
        <location>
            <begin position="461"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121118" checksum="B27AB1030EAE8513" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB0</accession>
    <name>A0A1U9NMB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondroitin polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kfoC</name>
        <name evidence="2" type="ORF">STSP2_01814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68646">
        <property type="protein sequence ID" value="AQT68646"/>
        <property type="gene ID" value="STSP2_01814"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01814"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="33246" checksum="085E0588571A0223" modified="2017-06-07" version="1">MPKISVCIPTYNRRDYICETIESILDQTYKDYEIVVVDDGSTDDTKQVLDEKGYPVRYHYQQNCGDAAARNTLIDLADGEYIAFLDSDDLYYPDTLERMIAAAETEKDDVIVYGPYMRIDENGGEISRCKRKLHSGWITDKLFQDILIHSCGSMFPAHILKGRKQFDTSLRVCSDYALWLELSLDYRFIALNEPTFNRRRHSGNLSEISVDNRLTELEVLKRFYYELGGKERINKTDAMRRLSRETYRVAKSARAEGKPDLAKKYFKESFRLKPNMKSFWHCLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB6</accession>
    <name>A0A1U9NMB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide core biosynthesis protein RfaG</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfaG</name>
        <name evidence="3" type="ORF">STSP2_02124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02124"/>
    <dbReference type="EnsemblBacteria" id="AQT68947">
        <property type="protein sequence ID" value="AQT68947"/>
        <property type="gene ID" value="STSP2_02124"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02124"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="43928" checksum="F5CB21299EC97DB2" modified="2017-06-07" version="1">MIKVAIILERADIALGGAERSIFELTRCLRANGVDVTLLAAKGKAQSGEVQILCTRKGKRITFKRFGKLLRRHFAENTYDIIHSTLPYDFADIYQPRGGSYPESIIQNAASYESAFKTRYKKLTHFTNLRRTQLVLAEKRLCRPQCSTIVAALSEYVKSQFVKHYHLSADRVRVIHNGVKLVTKLEPDAAKALQSQVRAKLGIAPGDKATLFLFAANNFRLKGLAQLIQALATVRKIDTEAEPYVVVAGSDSSQKYRAIAKDLNVANRIVFLGSLRSIQNALEITDLAVLPTFYDPCSRFILEALARGKPAITTKYNGAGEAFTDTVHGKRVDDPRNTEQLAQAMTYFCNEDNLRNAKHAIKEDGLAEKVSIDRHSREIIELYKDILKRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD0</accession>
    <name>A0A1U9NMD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69081">
        <property type="protein sequence ID" value="AQT69081"/>
        <property type="gene ID" value="STSP2_02267"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02267"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="168"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="353" mass="39593" checksum="195217A9E6F89DC5" modified="2017-06-07" version="1">MVPLVGSLSKGWMAKHLDVKFDRDYYFDPYRRHKVDLSCNEYAAKELGDLCIFYTESNLGQLEHFTNDQVLVGGIQPNMILGMLIGAEFITSDSMDADISMTPLKGVDPDRLPLPDKMIDHEIIKLFDQQIKEIRSQGDLQPIPPFFWDASGRATLHGTLTTAQKFLGESVFIDLMMQPEKVAKVMDWITESFIVLVKHFSKIADLPITSVHIGECSGCMVNPQMFEDVVVPHASRIARELGPLRFHSCGASTHLLESMKQMDGLHALDLGGDTSISKARELFGPAFPIDVAPMPADFSVDTPEPIISWAKQVIEENDGGRMQIIYHLEPDYKIENIRALQNFLKNAELKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME4</accession>
    <name>A0A1U9NME4_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1936003.STSP2_01932"/>
    <dbReference type="EnsemblBacteria" id="AQT68760">
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR013783">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346508" evidence="2">
        <location>
            <begin position="25"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="690" mass="74690" checksum="3DD16A9E10C2CDE8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG0</accession>
    <name>A0A1U9NMG0_9BACT</name>
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        <submittedName>
            <fullName evidence="9">Nitrogen regulation protein NR(I)</fullName>
        </submittedName>
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        <name evidence="9" type="primary">glnG_1</name>
        <name evidence="9" type="ORF">STSP2_02095</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ST-NAGAB-D1</strain>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="139"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="455" mass="50589" checksum="3E91FC988B4259F7" modified="2017-06-07" version="1">MNKTKGKVLIVDDDKDHADLLVESLQKQCSNAIAAYTAASAKSAIDRDGIDVVIVDYDLRSDTDGLDILQYAKQAKSSTKVILIADQNNTVACEQAIRMGAYEALTKPVDVDSLRLMVSKILPTRGDGKAVEDFEFPGVISRSHYMQGIYKVLRRVAPTNISVLIEGESGTGKELLARAIHENSDRRDNAFKPINCAGLTESLLESELFGHAKGAFTGATADRKGILEQADKGTLFLDEIGDMPLSMQAKLLRVLEDGIVVPVGATKAVVVDVRVVAATNHDLAKLVEEKKFRQDLYFRIKGVSLTIPPLRKRAEDIPELFGFFLRQACEELGRDIHRITESAMSILQSYHWPGNIRQLRHVIRTMVVMCDGDTLDVGDIPPDVHLVKRLSGRVEGQPDMSQDFVAQFTGRSLEEVEREHIRRTLDYTNGNRAEAAKILKIGERTLYRKIKEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK8</accession>
    <name>A0A1U9NMK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectic enzymes secretion protein OutO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">outO</name>
        <name evidence="3" type="ORF">STSP2_02006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02006"/>
    <dbReference type="EnsemblBacteria" id="AQT68830">
        <property type="protein sequence ID" value="AQT68830"/>
        <property type="gene ID" value="STSP2_02006"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02006"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="42621" checksum="E9173D6EB86FDC43" modified="2017-06-07" version="1">MELETIIMIFLFAFGSCIGSFLNVVIYRLPRDKSLVFPPSACPGCDKRIAFYDNIPILSWLLLGGKCRACKQKISPRYIVVELITGLLFLALYVAYFKSGMRRIEIAGDTGFQAFVHGGWFFYLISITLIAAFLAGSAIDLDLWVIPLSLCWFVTAAGFIGSTAAPYIIEANVVRDFHLFPTAGAKTGALAIGSSIGLMISLIGLKLGLLPQSYAFEQDQDADTEIDEESINHRLEAWREIVFLMPVIVLTAVAWIVYRSVPAFQSWCIDITTIPPISGLLGSIWGYIIGAAVVWATRIFGTLGFGKEAMGLGDVHLMGAAGAVIGPVFATVAFFVAPFFGIAWAIYQAFFQKTRQIPYGPFLSLGVFAVMILHDWMVAYWSSRYFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN2</accession>
    <name>A0A1U9NMN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02242"/>
    <dbReference type="EnsemblBacteria" id="AQT69057">
        <property type="protein sequence ID" value="AQT69057"/>
        <property type="gene ID" value="STSP2_02242"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02242"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010415">
        <property type="entry name" value="LpxI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043167">
        <property type="entry name" value="LpxI_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06230">
        <property type="entry name" value="LpxI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="LpxI_C" evidence="1">
        <location>
            <begin position="150"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31102" checksum="E34237AEEC8096A5" modified="2017-06-07" version="1">MPSRTPKQTLGLIAGEGRLPFLVADGARRAGLRVVCVGLADSADPELADHTDVFFEGVVTRPAGWMRKLRKQGVSSTIMVGRVKKTAMYTPWRIIRYLPDWRALRIWYWRLGKTDKRDDTVLNAIAAELASGDIILEDSTMYCKEHIAEKGVMTKTQPGATIKEDIEFGWQIVKRLGELDIGQAVAIREKDIIAVEAIEGTAKMIKRAGELCPKGRWTLIKAAKPHQDMRFDVPCVGPDTVENLAENGASCMVVEAGKTLILDKPETIQLADKLGVAIVGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP2</accession>
    <name>A0A1U9NMP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">etfB_2</name>
        <name evidence="3" type="ORF">STSP2_02176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02176"/>
    <dbReference type="EnsemblBacteria" id="AQT68998">
        <property type="protein sequence ID" value="AQT68998"/>
        <property type="gene ID" value="STSP2_02176"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02176"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28725" checksum="680EC39B2DF182BC" modified="2017-06-07" version="1">MANKIVVPIKQVPETKSVKMDEKTGTVIREGVDSIVNPLDLYAIEAALRLRDRYGGEIVGISMGPKKSVKALKEAVSMGVDSAILLSDRAFAGSDTWATSLILASAIRKIGDFGLVVCGERATDGDTGQVGPGIASFLGIPALTYVSRIQDLSDKLCRAERLIEDGREILETSLPAVLTVIKEAGEPRLPTLRGKKRAKDLDVQIWGNDELGIDPDKIGLKGSPTRVVKIYRPKVARKCTIAEAKDEASVGPAVDRMCGFLADKGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT6</accession>
    <name>A0A1U9NMT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02451"/>
    <dbReference type="EnsemblBacteria" id="AQT69262">
        <property type="protein sequence ID" value="AQT69262"/>
        <property type="gene ID" value="STSP2_02451"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02451"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="175"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="512" mass="56741" checksum="81A7289A4E287903" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV4</accession>
    <name>A0A1U9NMV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lpxD_2</name>
        <name evidence="6" type="synonym">lpxD</name>
        <name evidence="8" type="ORF">STSP2_02243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02243"/>
    <dbReference type="EnsemblBacteria" id="AQT69058">
        <property type="protein sequence ID" value="AQT69058"/>
        <property type="gene ID" value="STSP2_02243"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02243"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="7">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35560" checksum="090C7354C0A5AD81" modified="2017-06-07" version="1">MHGITLRELAEHVDGKVAGDPDLVVESVGTLENAEPNQITFLSNKKYLPLLKTTSAGAVITSEETDSPASLLIAEDPYYAFMQILVLIHGHRKHPSTGISERAFIAESANVGEGTQIAHGATVSENVKIGNNCTIYPNAFIGPDASVGDDCIIYPNVVIYDNTRVGDRVIIQANATIGVDGFGFATHNGEHHKIPQIGRVILEDDVEIGANGSIERGTLDDTVIGKGTKIGDMVAIGHGTRVGPHCLLVPQVGISGSTTLGHHCVLGGQVGVVGHIKIGNMVKIGAKAGVGNDIPDGATVLGTPAVEAGKAKRIMMSSLSLPEMRKRLKAVERKLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN40</accession>
    <name>A0A1U9NN40_9BACT</name>
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        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02405"/>
    <dbReference type="EnsemblBacteria" id="AQT69217">
        <property type="protein sequence ID" value="AQT69217"/>
        <property type="gene ID" value="STSP2_02405"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02405"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="446"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="576" mass="63306" checksum="C75E1B0F5F98D875" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE5</accession>
    <name>A0A1U9NNE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrK_2</name>
        <name evidence="4" type="ORF">STSP2_02609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02609"/>
    <dbReference type="EnsemblBacteria" id="AQT69419">
        <property type="protein sequence ID" value="AQT69419"/>
        <property type="gene ID" value="STSP2_02609"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02609"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="31151" checksum="45090EE84F365A64" modified="2017-06-07" version="1">MAHKIIKKQQLSENVFTVDVKAPLIAEARKPGQFVIVGLDAEIGERIPLTIAGADTEKGTIRLVWQRVGKTTAQMSELNIGDEMGYIAGPLGTPTHIEKFGKVVCVGGGIGNAPLLPIARALKDAGNEIVTVLGARTKNLLILEEDFASISDELIIVTDDGSCGRKALVTEPLEEICKQSPKPDLAMVIGPAIMMKFCSEVTRKYDVPTQVSLNTIMVDGTGMCGGCRVEVGGETKFVCVDGPEFDGHQVDFDQMMKRQAAYKDLEKKAYEQYQHKCRIGLDANNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE8</accession>
    <name>A0A1U9NNE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69264">
        <property type="protein sequence ID" value="AQT69264"/>
        <property type="gene ID" value="STSP2_02453"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02453"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002060" evidence="1">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="55"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="32783" checksum="BE0DFE64286F8871" modified="2017-06-07" version="1" precursor="true">MTSVRIVAAVCVVSLFLTAGCNSTPVSKAERVDDWRLGTSPWSEKLATLDKAKLAEIESLGFDCIEVGLPYAQNEEQFAGANAQAERLAETADEVGIEIWSVHIPYGPAYDPSLVDDAARAKAVANIDSLLGAIEPLGAKKAILHASFEPVKTEERAAKFAACKASLKEIADIAAGHDIAIAVECLPRTCLGNTSTELLELVSVDERLEICCDTNHLLQETTEEFVRAAGHRITTLHIADYDAKDERHWLPGKGVIDWMAVMDALVETGYTGPFLFECRGTSAEEAEVFAKLKAEYMERVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI1</accession>
    <name>A0A1U9NNI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69288">
        <property type="protein sequence ID" value="AQT69288"/>
        <property type="gene ID" value="STSP2_02477"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02477"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17903" checksum="3B35318DE31386AD" modified="2017-06-07" version="1">MKNNDILLVVTIILAIVFLSWFFIREHAEIDARIGNTMKGLTRERLASFEFNAGLRWNQKCPPETLVQMVSCFKEEYDGQEGLGYGLGIDIEKMRVLDYWKQPVRLKIISRYCYQLVSPGPNQTYENGTGDDIVHSFNPYEWDSLKLNCGTSQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM7</accession>
    <name>A0A1U9NNM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69220">
        <property type="protein sequence ID" value="AQT69220"/>
        <property type="gene ID" value="STSP2_02409"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02409"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="225" mass="25589" checksum="B2691D9ECC14B646" modified="2017-06-07" version="1">MYEVYWTRANRIKAAVIAFLLLSVGTAYMYKYNMSILKARLDLFDFIFCLPIAGPFLAIAFYVIFAVKRITSEITPDSVSSVAKAFVWIACVFLSGYVVWLEKRFFDPGTAWSLTGIMLVGILLYAGLRLLLLRLFGLPNAINWRRRRNQAHIFFMIFAILFWGALVGVVGRLVEPEKFYFESPLILAAIVMAWGTYRLGMYLALRNRPVAEDNGDVQAVEPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU4</accession>
    <name>A0A1U9NNU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppiB</name>
        <name evidence="7" type="ORF">STSP2_02593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02593"/>
    <dbReference type="EnsemblBacteria" id="AQT69404">
        <property type="protein sequence ID" value="AQT69404"/>
        <property type="gene ID" value="STSP2_02593"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02593"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18044" checksum="0AF50326B2D56CB6" modified="2017-06-07" version="1">MANQVKLTTSKGDITIELFEDQAPVTTKNFLQYVQDGFFDGTIFHRVINGFMVQGGGMTPDMNQKKTRDPIVNEADNGLANDRGTLAMARTNDPNSATSQFFINHNDNAFLNYQGPANPGYAVFGKVVEGMDVVDEIAEVETGRHGMHDDVPTETIMIEKAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX0</accession>
    <name>A0A1U9NNX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase</fullName>
            <ecNumber evidence="4">2.7.8.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wcaJ</name>
        <name evidence="4" type="ORF">STSP2_02805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.31" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02805"/>
    <dbReference type="EnsemblBacteria" id="AQT69611">
        <property type="protein sequence ID" value="AQT69611"/>
        <property type="gene ID" value="STSP2_02805"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02805"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="246"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="48684" checksum="E952A8AADA3C4B71" modified="2017-06-07" version="1">MRSALKDLGIQFSLLIADTVLIEIVFLASFLIRYGLPLPERNILAYESSSPLLTLIYILMFAICRAFKRRFTCHWDVFKHVACAMAVGTLFSFMAVYLFRFKWMAFPSSIFPISLVLGTIVISVSNMVILRLTGRIKKRVLVLGSKGQDFFFGGKKRLVLIHTHNIVDMPKYKDIDEILICEKIHEDSQLNLLIFLFLKSKVDVIFSPDLYDELLSNNLTEKTSIQFLSTFLGKKSGWEEFLIWSVDIISSIALLILTLPITIPTAMLIKLTSPGPVFYLQRRAGKDGKFFTLIKFRTMVDDAEHKTGPVLAQENDQRVTKLGRFLRQTRIDELPQLINIIKGDMSMVGPRPERPHFAKLHKALRGIRLAVKPGLTGLAQIRSSYDIKPEHKKKYDYLYIQRRSALLNIYLMIKTLPIILLRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX4</accession>
    <name>A0A1U9NNX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine metabolism repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cymR</name>
        <name evidence="1" type="ORF">STSP2_02792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02792"/>
    <dbReference type="EnsemblBacteria" id="AQT69599">
        <property type="protein sequence ID" value="AQT69599"/>
        <property type="gene ID" value="STSP2_02792"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02792"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="16310" checksum="E57B105925D3DC12" modified="2017-06-07" version="1">MKLSTRSRYGLRALLDLAKHVDEGPLQIKSIADREDISSKYLEQLMAILKSAGLVRSVRGPKGGYMLAKKPEEIRLSDVFVTLEGPMTPVECVEHTDYCSRCTDCITRQVWIEIHQAIMTVLESTTLQDLVDRAKSKKKLDFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA2</accession>
    <name>A0A1U9NPA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Zn2+ transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02948"/>
    <dbReference type="EnsemblBacteria" id="AQT69751">
        <property type="protein sequence ID" value="AQT69751"/>
        <property type="gene ID" value="STSP2_02948"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02948"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234089" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31121" checksum="8A7AF92526F4324E" modified="2017-06-07" version="1" precursor="true">MTSIPSKCLLSLLLLTAFIGCTSKEPANPAAEIAVTSTYLQSAILDIYPDANILCIASPGMCPGHFDLKPSQINQLRTSKALLLFDFQKSLLDQLKRVEADGLQCLTVTGRSGLCVPSTYLATCEEVAKQLTSIYPAHSNEFQKNLAMLRQRLAEFNPQTSPSFRPFTDTPVVCSQHQADFARWLGLRVVAEFHPSDAVTPPQIERCIQKARTQNAKLIIANQQEGTDLALSMAKRLNIQVAVFSNFPRISDPQNNFETLVRNNVKNLKKALNPEIPDHASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT8</accession>
    <name>A0A1U9NPT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69807">
        <property type="protein sequence ID" value="AQT69807"/>
        <property type="gene ID" value="STSP2_03004"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03004"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013205475" evidence="2">
        <location>
            <begin position="25"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="777"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="982" mass="106340" checksum="0F1C2C72B690D467" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU6</accession>
    <name>A0A1U9NPU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69961">
        <property type="protein sequence ID" value="AQT69961"/>
        <property type="gene ID" value="STSP2_03161"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03161"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6714" checksum="EA6B30458044049A" modified="2017-06-07" version="1">MMSPPKTTQEKRLAEEIKRLSRWRDELNEHITTLEMRLALQINEREHRQNGEQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW9</accession>
    <name>A0A1U9NPW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69982">
        <property type="protein sequence ID" value="AQT69982"/>
        <property type="gene ID" value="STSP2_03182"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03182"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="385" mass="43701" checksum="E5315BEC0E96B19E" modified="2017-06-07" version="1" precursor="true">MSKKRLVKLRFRKTKSRRGTGGAFFLDFNNPKTGKRVRISLGHGSYERAKRQQLRKEVELGSFDAGGCEGGRQRLSDIMIVYLQANKSMAAMTRDKTIRAFDYLIEVVGDIMLEKFDYSHAEAFQNFFVAKGFAPPTVNSYCKSISPVFSWAIRHQWIFVNPFVSVSGLREAKGFVRVYEPAEFAALWRVVDSDLWRARILAAKTAGLRRAEVLNLCRGDIDERSGVIRVQPKAKTSTTWRWRIKDHDAREVPLVPELAALLKKLGNALDDDQPYLMISGHVYHNKLDARMRGRLSDVARLCPDWQFSAEFSQLCKSAKISNATFHDLRRTVITEWLESGLQPHEVMQLAGHSSIETTMKYYTATRKTLLEKANKASSFALAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY9</accession>
    <name>A0A1U9NPY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toluene efflux pump outer membrane protein TtgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgF</name>
        <name evidence="4" type="ORF">STSP2_03204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70003">
        <property type="protein sequence ID" value="AQT70003"/>
        <property type="gene ID" value="STSP2_03204"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03204"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="387"/>
            <end position="455"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="489" mass="53842" checksum="C8916D2DB3A767A3" modified="2017-06-07" version="1">MTSESTKFALALTAAIGLLLTGCTVGPDYERPETPADTAGSYNAVPAEWHDPNQLPEPVTWWQNFGDPVTEKLVRLALEENYDLKSAAARVIESQAILRQAHGARWPQISYNADRLRAKRSLNTFGFGGSILTTDYSQDINITYIADIFGRLRRAEQAAYADLLSTTHAHYSLAHAIIAQVIRTRVQIATNQRLLDIARANTANWQRNLEIINRRYESGLVTPLDVRLARENLASSKAAEPSIQQALQLQYHSLDVLLGRPAGTTEELTKTLDDLPDLSPVPLGLPIDLLEQRPDVRQAEMQVAAATERVGVNIAQMLPDFTLTGSFGYNSSSFRQLTEAQNQVYSGIISLAAPIFQGGQLVAGVDAAKARVEQAAANYSGTILTAIKEVEDALVTLKNQRTRIAELRTQLDEALKAEELAGQRYVSGVDNILLVLETERRRRQAENQFALAKGNLWQARIDLHLALGGDWQITEIIDPVANKETGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ49</accession>
    <name>A0A1U9NQ49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03263"/>
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        <property type="protein sequence ID" value="AQT70061"/>
        <property type="gene ID" value="STSP2_03263"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03263"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20523" checksum="63D7AB5E9CC05FCF" modified="2017-06-07" version="1">MEPVKTVTYKNHTIEIHYDTTAESPRSWDNICEFHCSHRRYSLGDEGLNYSNPQDCIKAAQAAEKEGDLILPLYMYDHSGITISLSPFSCPWDSGQVGFVIVRRKKMLEEFGRKKFSKSLKEKALQIVEGEVGTYDHYLRGEVYGCIIDGGEESCWGFYGQEECIEEAKSIIDAMIEMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ51</accession>
    <name>A0A1U9NQ51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69740">
        <property type="protein sequence ID" value="AQT69740"/>
        <property type="gene ID" value="STSP2_02936"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02936"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013092486" evidence="1">
        <location>
            <begin position="29"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="538" mass="57272" checksum="ABF669617C4E3225" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ63</accession>
    <name>A0A1U9NQ63_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpoC</name>
        <name evidence="11" type="ORF">STSP2_03056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03056"/>
    <dbReference type="EnsemblBacteria" id="AQT69858">
        <property type="protein sequence ID" value="AQT69858"/>
        <property type="gene ID" value="STSP2_03056"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03056"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="230"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1403"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1425" mass="158871" checksum="9F4E05270197733F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ81</accession>
    <name>A0A1U9NQ81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70092">
        <property type="protein sequence ID" value="AQT70092"/>
        <property type="gene ID" value="STSP2_03294"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03294"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="17131" checksum="BCD647A231321E3F" modified="2017-06-07" version="1">MTDLQILHARLEDLAYHVTEPFCYGCYIKVEGENCPRCGSDDLMRHLDGVGVEYGTEWVIEQLIEDHCEPIDEEEAYSELLDEIYGEVKFDGIVFYPSDIIRELDPVAFRCGCNDYLAAEESDGQLYEVNGRYYRLYDIEEMIADLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ95</accession>
    <name>A0A1U9NQ95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03104"/>
    <dbReference type="EnsemblBacteria" id="AQT69904">
        <property type="protein sequence ID" value="AQT69904"/>
        <property type="gene ID" value="STSP2_03104"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03104"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48831" checksum="6AB5DDDF00B8DFCD" modified="2017-06-07" version="1">MEIKAFKGLRFNPDVVGDAGSCISPPYDVIDEDMQQALYDANPYNIVRVIQGKKSSEDSSDNNQYTRAAEFLKDAQQEQALKQDEKDTIYAYVQDFEINGQQQTRSGFVALGKIEDFGSGVKAHEKTLDGPKADRLNLMRATAAQFGQIFMLFNDPEKVADKIMEKAAQGAPLLSFTDDMNVVHKLFAIDDPADVEAVKNMMGDKQAIIADGHHRYETALNYWKETQNPDAQYRMMTFVNMHNEGLVIQPTHRLVMNMPEFDVEKLVEQLKDDFAVVQFNFNSDEAKQLARKKMFEQMNKAFENEKAALGIYAASGSFYVVTLKDFASMNDFADMSDAAKKLDVNVLHNLILDRAMGIDDAALAKQSNLKYIKDIGDAIERSIDAVDSGQSQVVFFMNPTRIEQVNAVAMAGEKMPQKSTFFHPKVFTGLVINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB5</accession>
    <name>A0A1U9NQB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemE_2</name>
        <name evidence="3" type="ORF">STSP2_03206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70005">
        <property type="protein sequence ID" value="AQT70005"/>
        <property type="gene ID" value="STSP2_03206"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03206"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="541" mass="59613" checksum="A1C3023C54A60CE0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK6</accession>
    <name>A0A1U9NQK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69900">
        <property type="protein sequence ID" value="AQT69900"/>
        <property type="gene ID" value="STSP2_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03100"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11150" checksum="0EE252A5DA263201" modified="2017-06-07" version="1">MDSVEVIRADNGNAGNICGTCVKGGECALKVKPDKPMIECEEFDTGASAEFNNSESGKLSSEPMKVGAVQGQLKGICADCSNRDVCVRAAHTGGIWDCDDYMEVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM8</accession>
    <name>A0A1U9NQM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69816">
        <property type="protein sequence ID" value="AQT69816"/>
        <property type="gene ID" value="STSP2_03013"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03013"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4351" checksum="E5725DDCBC4D97FA" modified="2017-06-07" version="1">MSIEHEDCDVMLCKMFVDAAVINPIALRLWSNLLGGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP6</accession>
    <name>A0A1U9NQP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03459"/>
    <dbReference type="EnsemblBacteria" id="AQT70253">
        <property type="protein sequence ID" value="AQT70253"/>
        <property type="gene ID" value="STSP2_03459"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03459"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12090" checksum="3D7AA1B4544A10EB" modified="2017-06-07" version="1">MPTYDYVCESCGHAFEKFQSITAKPAKKCPECGKMKLNRLIGSGAGVIFKGTGFYETDYRSDSYKQAQKGESTASSSSSDTKKSDSSESKTKSDSTTTKKESPGGDKKKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT8</accession>
    <name>A0A1U9NQT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein, rSAM/lipoprotein system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03390"/>
    <dbReference type="EnsemblBacteria" id="AQT70185">
        <property type="protein sequence ID" value="AQT70185"/>
        <property type="gene ID" value="STSP2_03390"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03390"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131350" checksum="C53FE477232A8321" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV0</accession>
    <name>A0A1U9NQV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70195">
        <property type="protein sequence ID" value="AQT70195"/>
        <property type="gene ID" value="STSP2_03400"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03400"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22894" checksum="D6735FC143C16AAD" modified="2017-06-07" version="1">MSKQSALEVVFNMVNGRQLRFRAHSEEDARNVIQSINPQKFFSERKEVSLFGNASQSSILLDAVAFMVFETPIKLDWPYPIHFSSAKILNRNLFIKAATDELPRVRQILDSNQAGKPIPLFLELVIEGGRHWFLRAESETLMPAERMQIPKTLRDITGFHATGPGGGGVLFNMNRVVSWTLHPPLTDPNSKAWRMAPIRENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV3</accession>
    <name>A0A1U9NQV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gliding motility-associated lipoprotein GldK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70311">
        <property type="protein sequence ID" value="AQT70311"/>
        <property type="gene ID" value="STSP2_03517"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03517"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040698">
        <property type="entry name" value="HZS_alpha_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18582">
        <property type="entry name" value="HZS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HZS_alpha" evidence="2">
        <location>
            <begin position="506"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="836"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120706" checksum="2BF439CBE0AF193C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX4</accession>
    <name>A0A1U9NQX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MscS family protein YkuT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ykuT</name>
        <name evidence="8" type="ORF">STSP2_03392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03392"/>
    <dbReference type="EnsemblBacteria" id="AQT70187">
        <property type="protein sequence ID" value="AQT70187"/>
        <property type="gene ID" value="STSP2_03392"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="305" mass="33569" checksum="90CCB2FD572D5855" modified="2017-06-07" version="1">MAFWEKIKEAFDLQAVLEAAGGILVTVILALIAQLIFSKLLDRLENRLIKKNEVEGEPPSESAKRIGTLIKLIKRGVYIAVWVVALVIVLGELNVEIGPILAGAGILGLAVGFGAQNLVRDVISGFFIILENQIRVGDVAIINGTGGLVEQINFRTTVLRDLSGVVHVFPNGTINTLANMTNEWSAHVFNIGVAYKENTDRVTEVIKQVCAEMREDPEFGPAMIGEEEIFGVDSFGDSAVMIKGRIKTKPILQWKTGREFNRRIKLAFDEKDIEIPFPHVSLYAGEATKPFDLQVLQKTKENASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ5</accession>
    <name>A0A1U9NQZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gcp</name>
        <name evidence="6" type="synonym">tsaD</name>
        <name evidence="8" type="ORF">STSP2_03369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03369"/>
    <dbReference type="EnsemblBacteria" id="AQT70164">
        <property type="protein sequence ID" value="AQT70164"/>
        <property type="gene ID" value="STSP2_03369"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03369"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="30"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="36457" checksum="BD857AEC89DF8E8C" modified="2017-06-07" version="1">MTNKKQINILGIESSCDETAAAVVTNGSRIRSSVVASQEDIHREWGGVVPELASRAHLENIYPVIKKAVDDANIDLHDIDAIAIANQPGLVVSLIIGVTAAKTLALTLDKPLISINHVHAHLQAAILAEENVELPAAALIVSGGHTNLYDCESPLDLRLLGSTIDDAAGEAFDKVASILGLGYPGGPVIDKVAKKGNPTAVRFPRSMMGKDSLDFSFSGLKTAVLYHCQGQDMKGTSQVDKMSEQEIADIAASFQAAVVEVLTRKTELAAQQIKARTVLVGGGVGANSALRESLTRSCEKSGRNLLIAPMKLCTDNAVMIASLAYHKYKAGLFADLTLEPKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR05</accession>
    <name>A0A1U9NR05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="7">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fgs</name>
        <name evidence="7" type="ORF">STSP2_03461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03461"/>
    <dbReference type="EnsemblBacteria" id="AQT70255">
        <property type="protein sequence ID" value="AQT70255"/>
        <property type="gene ID" value="STSP2_03461"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03461"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="83"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="476" mass="52622" checksum="72972B4E4007777C" modified="2017-06-07" version="1" precursor="true">MTKSTKKTKSTKTKKASRGTTSKVRRKKVFKSYTKAIKYLFERTDYEKQRRLRYNVSTFDLTRMEKLLAGVDNPHLKTDVVHIAGTKGKGSTATMLAKMLEANEYKVGLYTSPHVTTLHERIVVNSKMIADKEIIGLLNRLHATIEKLADEDDAPTFFEIMTTMAFMYFADKEADIAIVETGLGGRLDSTNVVQPLLVGITNISIDHQNLLGNSLPEIAAEKAGIIKEGVPVVTVPQHADAMRVIKKRALECGSPLLVTGTDVDFSSRFESSREHGPHTRICLTTPNSRFEHLRVPLPGQHQAVNCGLALAMLDALKSKIEIDDSKAVKGLAEVSMAGRMEIICDDPRIIVDTAHNAASIRALIHAIGQHVPYDSMIIIFACNQDKDVRGMLNQLQFGADKVIFTRSNSPKAVFPQDLADMYTEICGKMCQTAMTLREAVRIAKSAVSREDLICITGSFYLVGQAKDQLQIRTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR12</accession>
    <name>A0A1U9NR12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69956">
        <property type="protein sequence ID" value="AQT69956"/>
        <property type="gene ID" value="STSP2_03156"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03156"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011231">
        <property type="entry name" value="Phage_VT1-Sakai_H0018"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09956">
        <property type="entry name" value="DUF2190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25494" checksum="5179E5E31D8F87AE" modified="2017-06-07" version="1">MELESIFKLGYGRLDYTAGGDGATSGQVVQVAGKAGVVTRDLDDSEAGYADVEGIFQIRAAAVVGNAGDNAWWDEDGDPYGDSDNAGKGALTTIASDGDFWVGTLVEDLAATDGEVKVALNVETPGLPAWTGKTHETKDDDYTVDAQDNGKVLHIATDAKTFTLPATSAGFEITFVNDGADAVVELTVSPNANDKITGVDLAGADNKDIVNTKATAEHGDFITLVGNGGDGWYIKAIRGTWALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR32</accession>
    <name>A0A1U9NR32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ddlB</name>
        <name evidence="7" type="synonym">ddl</name>
        <name evidence="11" type="ORF">STSP2_03409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03409"/>
    <dbReference type="EnsemblBacteria" id="AQT70204">
        <property type="protein sequence ID" value="AQT70204"/>
        <property type="gene ID" value="STSP2_03409"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03409"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="107"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33819" checksum="487E0728C64D3FA4" modified="2017-06-07" version="1">MSPSLENLKVAVLMGGISSEREISLESGSTVAGSLAEAGLDVVEFDVAPDRLSILDDESVDVFFPILHGEWGEDGQLQQILTDRGLCFTGSGPDASRIAMDKVACKKAVESKTDVPLAGHVELTSDTGEDDVRNMLASMGDKFVVKPPLQGSSVGVTVVQGLDSACRCALKTLAEYGNCMVEKFISGRELTVAVLDGQALPIIEIRSKTGFYDFNAKYVDNATEYLFDTIADQALVSRISDMALQCFDAVGCRHWGRIDFILSEDGTPYFLEINTLPGFTSHSLVPMAARKAGISAPELCTRIVEAAIRDHRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR61</accession>
    <name>A0A1U9NR61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03511"/>
    <dbReference type="EnsemblBacteria" id="AQT70305">
        <property type="protein sequence ID" value="AQT70305"/>
        <property type="gene ID" value="STSP2_03511"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03511"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010742141" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29838" checksum="125475ED52C4C323" modified="2017-06-07" version="1" precursor="true">MILLRIFTAITLVSVVPFAMAQGAQEEVDLGGWDFEFTPYFWAAEVEGDMTLRGRTGDVDANFSDIWDNLNIGLMGRIEGWRERWGWFVDGLYLDLESDFTTPGALVSGDVDIDWTILEFGLGYHLIESDGGDGTAAGFDVDLLAGGRYQNIKGELDIVTSGPLADVVSGGSFERRGEWVEPLVGGRLRWEWGRNIAFLCRGDIGGFSVGEASKLTWNILAGIDYELCETTSVRFGYRIFDMDYSNGSGTEKFGLDTRFKGPILGLAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB1</accession>
    <name>A0A1U9NRB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70317">
        <property type="protein sequence ID" value="AQT70317"/>
        <property type="gene ID" value="STSP2_03523"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03523"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13026" checksum="35DAD2EF183F2221" modified="2017-06-07" version="1">MVKVGRWVIFVFVITVVFTLTHIPQVNMPSDLGVGNFDKILHAGAYGVLAFVGIWAVGFGRGWRGYVGLAMMLAGLGVVDELTQPWVGRTCGVDDWAANVVGIVVVLGVVRVAGGWGRGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRJ6</accession>
    <name>A0A1U9NRJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03550"/>
    <dbReference type="EnsemblBacteria" id="AQT70344">
        <property type="protein sequence ID" value="AQT70344"/>
        <property type="gene ID" value="STSP2_03550"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03550"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="501" mass="55740" checksum="07FB47B48C9CE07B" modified="2017-06-07" version="1">MYNGLRKNTLYYLTALVLALLVYIPSTAPGALWQDSGMFQYRVYNGDIEGGLGLALAHPLYHLIGFAVKSIPLGEFGYRVNLISAVCGALTIANIFLLVRIWLRKTLPAAVAAISLALSWTFWQHSAIAEVYTLYTAIFSAELIVLYMFCKTNQPRYLILLGFVNGLSIANHMWGIIPLAVYGCMAIYVLAKNRNTWPVFAAFILAWTVGAFPYEYLIIEQYLETRDLPAVISSALFGSSWASDALNVAITPRIALENVLFIGLSFATPNILLIFAGCYAIRKTAGPAMFKTVIAILLGLFFIFAFRYTVPDRYAFFIPFYCLSAIFMGVGANWLLKRTSSGAIPVIVLIFAFLPPLVYFFVPAMAQKAGVSLGTKRQIPFRNDYEYFLQPWQGGNTGPQQFAESALNQVPEDSIIIADGTTVYALWYAQAVHNMAPSVKVLSNHGDYENPIAFPDVKALEKLLQSHDIYVVSPIPGYTPKFMLENYDFKTAGNLHKVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRW7</accession>
    <name>A0A1U9NRW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD</name>
        <name evidence="5" type="ORF">STSP2_03472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03472"/>
    <dbReference type="EnsemblBacteria" id="AQT70266">
        <property type="protein sequence ID" value="AQT70266"/>
        <property type="gene ID" value="STSP2_03472"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03472"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25424" checksum="1CD0BEAE7CEC5593" modified="2017-06-07" version="1">MPKILKASSIYKSYRMGQAKLDVLKGLDLSIKEGEFVAIVGSSGSGKSTLLHILGALDKVDKGRVQFRGKDLDKFSVMDYARFRNKMVGFVFQFYHLLDELNVLENVLLPSMAGTGMFGWAARKKTAVERAEMLLDKMGLSERLKHKAYQLSGGERQRVAIARALMNNPVLLLADEPTGNLDSVTGNGILESLAHFNAEGQTIVMVTHDDRVAQKADRTIRLVDGKIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGF0</accession>
    <name>A0A1U9NGF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of competence-specific genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00157"/>
    <dbReference type="EnsemblBacteria" id="AQT67019">
        <property type="protein sequence ID" value="AQT67019"/>
        <property type="gene ID" value="STSP2_00157"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00157"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="13011" checksum="FFEEE38E72AEECE2" modified="2017-06-07" version="1">MTVSDEYLEYVLDQLRFVDDVTYRKMFGAIGIYSGPDFFAIIDEDVLYFKVDDHNRPDYESAGTDAFRPYEDPDMTMSYYEVPVDVLESADTLAVWAQKAIAAARRKKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL9</accession>
    <name>A0A1U9NGL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">flhB</name>
        <name evidence="14" type="ORF">STSP2_00045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00045"/>
    <dbReference type="EnsemblBacteria" id="AQT66907">
        <property type="protein sequence ID" value="AQT66907"/>
        <property type="gene ID" value="STSP2_00045"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00045"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT66907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="355" mass="39424" checksum="360F3D344F5DF38B" modified="2017-06-07" version="1">MADKPAGERTEQPTPRRLRKAREDGQAPQSQELPAVASIVALLLAFVAGGSGLFGWFRELIRNACTCNFQALETSGAFMKYASGIIKGMIGAMSPFFIAVFVAGVMSTVVVSGLNFSPKAVKFKLSAISPVKGFKKLFGIQSVIKLVLSVLKLIFVGMLVWFYLDDKLESMASLRWAWPDNLLKILGEPVLGIMIRICIGLIIIALIDVAFQKWKYIRDLKMTKQEIKEERKSEEGSPEVKSKIRQQQMAMASKRMLAEVPKADVVLVNPTHVAVALKYDSKKSDAPVVIAKGGDHLCERIKEVARSYGVPIVRRPKLARTIFANVELDQSIPESLFMAVAEVLAMIQRMRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM4</accession>
    <name>A0A1U9NGM4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">msrB</name>
        <name evidence="5" type="ORF">STSP2_00231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00231"/>
    <dbReference type="EnsemblBacteria" id="AQT67091">
        <property type="protein sequence ID" value="AQT67091"/>
        <property type="gene ID" value="STSP2_00231"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00231"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19802" checksum="92A317523DB09DEA" modified="2017-06-07" version="1">MKLTAIISVIIIALTQSGCRRVEPGSVAAPQPTKGVPMSYEVEKSEQQWREDLTRDQYNVLREGGTEKPFTGKYYKFFEDGVYKCGACGEELFYSKDKFDSGCGWPAFAQPTQRENIEERIDKSHGMVRTEIRCAKCGSHLGHVFTDGPAPTGLRYCVNSAALEFNAMIGTEKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR8</accession>
    <name>A0A1U9NGR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylxylan esterase</fullName>
            <ecNumber evidence="3">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">axeA1_2</name>
        <name evidence="3" type="ORF">STSP2_00086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66948">
        <property type="protein sequence ID" value="AQT66948"/>
        <property type="gene ID" value="STSP2_00086"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00086"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011984735" evidence="1">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="25124" checksum="CFBB8B9E3DE78956" modified="2017-06-07" version="1" precursor="true">MRNVLMSLVLAVIVFGSGCTANKCRPVDTGKFDRPVRVACVGDSITFGSGISNRNVNSYPAQLGDMLGDKWDVKNFGVSGATLLQKGDKPYWVQAAYQQSLNFKPDVVVIMLGTNDTKPQNWKHADQYVPDFKKLIDNYRRVNPDARIWICKPVPAFPGRWGIRESVIKDEMLHMVDEIAEEKNVCEIDLHETLTGKGDLFPDTVHPNAEGARVMAQEVRTALTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ9</accession>
    <name>A0A1U9NGZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fas6_1</name>
        <name evidence="3" type="ORF">STSP2_00342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00342"/>
    <dbReference type="EnsemblBacteria" id="AQT67199">
        <property type="protein sequence ID" value="AQT67199"/>
        <property type="gene ID" value="STSP2_00342"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00342"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="252" mass="28293" checksum="FD29FA9848322569" modified="2017-06-07" version="1">MTIRHRPGNNSHNHKKSMIAGASHMPSEEPWRIFRIMAEFVEGFEELATVGPAVSIFGSARTKPGHPYYELAEETAYEVGKAGFGVITGGGGGIMEAANKGADRAGVMSVGLNIELPQEQVPNEYQNMSLHFRYFFCRKVMFLKYANGFVVMPGGFGTMDEFFESLVLIQTLKQAYFPVILMGREYWADLLKWIEDKMLGAEYIDKDDLNVYTVIDDPREAAKLLVDFREKKGKGGLEEPPGIKRPAGQQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH74</accession>
    <name>A0A1U9NH74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67283">
        <property type="protein sequence ID" value="AQT67283"/>
        <property type="gene ID" value="STSP2_00426"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00426"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025293">
        <property type="entry name" value="YfiR/HmsC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13689">
        <property type="entry name" value="DUF4154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28987" checksum="F21366BCBBDFE72A" modified="2017-06-07" version="1">MIEFVKNPIRFITKWRCHVMGLLRSFLTALIFLGIGCGLAVSAAPLPNAFQTEANSEVSREYKLKAAFIYNFTKFITWPDKAFQDGTSSTGRQKDAPIVIGIIGKSPFGDAFKPITEKKVRGREVKILQIKGPSQLLRNRSNPNHEQINNCIKSEIEKIKKCEVLFIAPSEHKYVGRILKNTAEMHLLTISDFPGFADKGGMINFVKSGRKVRFEVNLAVAKKHKLKISSKLLSLAVRVIQDEPDEKAASPADKPGRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH88</accession>
    <name>A0A1U9NH88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67104">
        <property type="protein sequence ID" value="AQT67104"/>
        <property type="gene ID" value="STSP2_00245"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00245"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12231" checksum="CFA2E679B417F243" modified="2017-06-07" version="1">MCSKKYSSVYDAGDEYLDEENLDSDEELEEIAERSEKILSEGAGTNPESGDDLDEGYESEDEFDEDELDERYAEIDFGDDSFDEDEFGGMDDDFPEDLGDLGLDDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC2</accession>
    <name>A0A1U9NHC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67158">
        <property type="protein sequence ID" value="AQT67158"/>
        <property type="gene ID" value="STSP2_00301"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00301"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7271" checksum="0ABA9A463A11182C" modified="2017-06-07" version="1">MKSSRFTSDNVLHENDEVLLLMIAFGSPPTRKIAADELSRRGRDVSPGDVALAVMTNFYTLGPTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD1</accession>
    <name>A0A1U9NHD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67168">
        <property type="protein sequence ID" value="AQT67168"/>
        <property type="gene ID" value="STSP2_00311"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00311"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11973" checksum="95F6D298406D3232" modified="2017-06-07" version="1">MDAVVKEIIIHARGGFASGFMGVFFLSPRDNTGAAGRGACKESLRDGFIMLGPVSGYGMTILCHHSLVDSKVAWYELVGWVDLADYNRFCGVVVASWADVEGHCGEEGEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH5</accession>
    <name>A0A1U9NHH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67371">
        <property type="protein sequence ID" value="AQT67371"/>
        <property type="gene ID" value="STSP2_00515"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00515"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14951" checksum="DF86BF8AD79475FA" modified="2017-06-07" version="1">MVRIPNSLWGYFWYMVLLTVAVLIVAMLLNLGVDPVAVPVVTVVNEAGGEVRGVELVCGEKAEGRLVMDSKHVGELAAGEQADVVIVPREKFSLAVRWQATDGEEFEREVGEGLVPGEIDRIEIVLKADGEVDMEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI7</accession>
    <name>A0A1U9NHI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67237">
        <property type="protein sequence ID" value="AQT67237"/>
        <property type="gene ID" value="STSP2_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00380"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211444" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10661" checksum="09B2CBEBE2157F5A" modified="2017-06-07" version="1" precursor="true">MGRKIVCAAGVFVLAVLFAGGCADGWERCEAEEGEISPRLGRLKENYEVEGEKQSFEVKWRYRGEGLELSRERVDVYDERRSGMDEFGADGFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT4</accession>
    <name>A0A1U9NHT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00509"/>
    <dbReference type="EnsemblBacteria" id="AQT67365">
        <property type="protein sequence ID" value="AQT67365"/>
        <property type="gene ID" value="STSP2_00509"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00509"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="29820" checksum="653778DE530C7165" modified="2017-06-07" version="1">MFAVISDIHSNIEALTAVLDDIKSKGIEKIYCLGDIVGYGPNPKECLDLIIEKTEFAVQGNHDYAVLYEPTNFNTGAEMAAHWTRNFLEEEKDAANREKWWNFLGEQIMRRSKRMKLGDVDAHIDFVHASPRRPINEYVFPDDVFTLPGKINGLFDMVEHICFIGHTHLPGVFLEDPDFYTPDELGEYYPVIPDEKAIINVGSVGQPRDRDNRASYAYVKENEVYFVRVEYDYEKTAKKIYEIDQLDDFEGERLYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV1</accession>
    <name>A0A1U9NHV1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00323"/>
    <dbReference type="EnsemblBacteria" id="AQT67180">
        <property type="protein sequence ID" value="AQT67180"/>
        <property type="gene ID" value="STSP2_00323"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00323"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27540" checksum="7C1864CBD554D071" modified="2017-06-07" version="1">MNLILVDKCDEVGAGVYRLGDARGRHVRRVLRAGVGDELKVGLINGPKGTAVVRSVGLEAVELECEFAGEMDVPDVEVDLVCGLPRPQTLKKVLQSAATMGVRRVHFVDGKRVEKCYFSASVLDEVNVVGHLLEGMSQGRQTRMPMVFVHRWFRRFFWYTLENLERAEEVKAKRLLTDMAVEDYLAAMDAEGVRRVLLAVGPEGGWVQSEIDMMVDAGFEKFRLGAWPLRVENAVVAALGQLELAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI25</accession>
    <name>A0A1U9NI25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67571">
        <property type="protein sequence ID" value="AQT67571"/>
        <property type="gene ID" value="STSP2_00719"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00719"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="29036" checksum="A3E008936565CCBF" modified="2017-06-07" version="1">MRLGKNDCLMILLCCVFMFMAMGAMGRGSKRAKTLICQSNLRKLGQIATLYAQENDGKGFSLEYANMWCQRLDEYTNAVDSILLCPETVSRDYDEYGSYRYGDSRTPWMWNYNREEQRIGTYAFNGWLYIRESYYGSEEKNFKDFNEIQKPSRTPVFADGNWVDTWPDESDEITAECDLTGEATGHHENGMMVRVTMDRHYGVTNVVFADGHAEAVPLSKLWSLNWHKGWQPKYNVKREDGSPIYKANSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI27</accession>
    <name>A0A1U9NI27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxB</name>
        <name evidence="2" type="ORF">STSP2_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00403"/>
    <dbReference type="EnsemblBacteria" id="AQT67260">
        <property type="protein sequence ID" value="AQT67260"/>
        <property type="gene ID" value="STSP2_00403"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00403"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35912" checksum="7EC8FA164D6FF5C3" modified="2017-06-07" version="1">MSDKVYDCIIVGAGPAGLAAAIYTARDRKSTLMLEKQYPGGQITVTDRIENYPGYDRISGPDLVMKMLEQAQNFGAELKSGVEVTEITKLDDGNTRLDTTEGPFLAHCVILSPGSSFRKLGVPGEEKFRQAGAGVSYCGTCDAPFFRDKKVIAVGGGNTAVEETIHLAKFAAEVTLVHRRQEFRATPVLVEELMDNVNSSDGNIKLVLDSVCTSINGTDKVESATIQNVKTEETSELDCDGVFIFIGTVPNTDFLKDTFEVTESGFLRCDPVFLRTAMPGVFVAGDCRVDAPMQLATAVGDGVAAAMAMKSFCRDPKWWDMPAFDSLTPGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB4</accession>
    <name>A0A1U9NIB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DMT superfamily transporter inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67488">
        <property type="protein sequence ID" value="AQT67488"/>
        <property type="gene ID" value="STSP2_00635"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00635"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="299" mass="31791" checksum="87A305D06E80B4FF" modified="2017-06-07" version="1">MRFRDIFLPAVGFVLLWNSGFIGAEYGLPYAGPFSLLFWRYAALTGILFVSLLVRGRLRWVGWRSAGVNMTVGFLAHGVWLGCVLLALDRGVPAGIVALVVALQPLATGAFSGVTAGEPTGLKRWIGLFIGFAGVAVTVGFRIDLGDAGSVFGYLVPLGSVAAITAASLIQRRLDVRHDAKVLPVDLALFYQCAATAVVMAIPAIFAERLVTEWAVPFVLTMLWLVVGVSLGAYGLMWVLIDRLDATRVASLFYLGPPVTMLMAWGAFGDVPRGMDLVGMVIVFAGVGLSCARGPAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF0</accession>
    <name>A0A1U9NIF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HTH-type transcriptional repressor NsrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nsrR_1</name>
        <name evidence="1" type="ORF">STSP2_00857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00857"/>
    <dbReference type="EnsemblBacteria" id="AQT67709">
        <property type="protein sequence ID" value="AQT67709"/>
        <property type="gene ID" value="STSP2_00857"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00857"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14710" checksum="F2083747847A438F" modified="2017-06-07" version="1">MDVIRRDTDYALRAMAMLAQLESGKAVSTKQISTEQQIPSALAAKLMQKLQAAGLVKSKMGPKGGFSLSKHPQKISIADVVLAIQGPVSINKCLTGSFQCPINAKCPLHKKLGKLQSQMDQYLTETTLADVAAPEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF4</accession>
    <name>A0A1U9NIF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CsbD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00662"/>
    <dbReference type="EnsemblBacteria" id="AQT67514">
        <property type="protein sequence ID" value="AQT67514"/>
        <property type="gene ID" value="STSP2_00662"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00662"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026042">
        <property type="entry name" value="YjbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039008">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="2">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7718" checksum="023A0EBDC6D9D2ED" modified="2017-06-07" version="1">MKATVLKGKWNELKGAMKKKWGKLSEDDLKQVEGSKDKLVGKIQEKYGKSKEQAEREVEEWHEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN0</accession>
    <name>A0A1U9NIN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00732"/>
    <dbReference type="EnsemblBacteria" id="AQT67584">
        <property type="protein sequence ID" value="AQT67584"/>
        <property type="gene ID" value="STSP2_00732"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00732"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="342" mass="38440" checksum="3AB7FCFB2A58BF3C" modified="2017-06-07" version="1">MEILITIVVILTVLVLILLAVLMLSNNASRRDLAAQSASINMLTQQLDSLKGSQDNISQTLEKNLTTGQQNITRTLQASHETLSKLHTQIGHLQGSSSQILQLGTDVRKLQDILKSPKMRGQLGERSLENLLSDILPAGSFNLQHPFKSGKIVDALITLPDYSVPVDAKFPLPSFEAMLAAENDDLKKRLRRQFQSDVVKHIDKIAAQYINPDEGTLDFALMYIPAENVYYETIIKYETDRTDVLNHALEKKVIPVSPNLLYVYLMTIVMGLHGLQIEKQAARIRTNLGKLSGLFDDITQTYTVLGKHLKNAYSQYDEGQKRIDRFSMNLDQITNDHEETPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN4</accession>
    <name>A0A1U9NIN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">yidC</name>
        <name evidence="16" type="ORF">STSP2_00510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00510"/>
    <dbReference type="EnsemblBacteria" id="AQT67366">
        <property type="protein sequence ID" value="AQT67366"/>
        <property type="gene ID" value="STSP2_00510"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00510"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="102"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="656"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="682" mass="75005" checksum="1B44BF48B57C06DD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR3</accession>
    <name>A0A1U9NIR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67819">
        <property type="protein sequence ID" value="AQT67819"/>
        <property type="gene ID" value="STSP2_00969"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00969"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4159" checksum="0B3E211D35D28D37" modified="2017-06-07" version="1">MNDGYVGSLLSKCNEVLNRKLTVDGERESEGFARLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT5</accession>
    <name>A0A1U9NIT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formylglycine-generating sulfatase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67839">
        <property type="protein sequence ID" value="AQT67839"/>
        <property type="gene ID" value="STSP2_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00990"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="33482" checksum="384366CC6ADEAEA5" modified="2017-06-07" version="1">MNNIYSKRFTIMTAIVVCCISTVAFVIYELSELIRLTNLDEPLIGVAFFFAAWYAIQFAAVSLLISWSVVLLLQGSIAFLKKKEIAGVGKAHYLVALLLIASVSLLYGSTVADFIKTVVPVKVIENEGFTNSMGMEMVKLNADYYVSRYETTQEQFEKLMGCNPSHFVGPALPVESVTSAQARTFCEKATELDRQKGKLPKGYSYALPTFDQWQQYVADAALDGSVTPAGSKQYLNSTRPVGSGTVNRLGLYDLRGNVAEISHDGQISFGASWNTARKDFLHPLNQNNFSGDNSETGFRCVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU7</accession>
    <name>A0A1U9NIU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 12">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemB</name>
        <name evidence="14" type="ORF">STSP2_00894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00894"/>
    <dbReference type="EnsemblBacteria" id="AQT67745">
        <property type="protein sequence ID" value="AQT67745"/>
        <property type="gene ID" value="STSP2_00894"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00894"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT67745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35426" checksum="5341EB9C8EC2425D" modified="2017-06-07" version="1">MFPTVRMRRLRNNDATRRLVRETTLNVDDLVYPLFVCPGESVKRPIKSMPGCFHFSPDKIIEEAKEIAHMGIPAIMLFGLPETKDPTGSDASNESGPLCNAIRNIKKSVPELLIITDVCLCAYTDHGHCGVISNGKVDNDRTIALLAKTALAHANAGADMVAPSDMMDGRVNAIRRLLDEKAFEQVGIMSYSAKFASAYYGPFRDAAGSSPAWGDRRAYQMDPANGKQAMREMQQDIEEGADIIMVKPALAYLDIIANARRRFDLPIAAYNVSGEYMMLNAAAEAGLIDHNATIMETMLSFKRAGTDIIITYFAKEVAKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX1</accession>
    <name>A0A1U9NIX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-stereoselective amidase</fullName>
            <ecNumber evidence="2">3.5.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ramA</name>
        <name evidence="2" type="ORF">STSP2_00603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00603"/>
    <dbReference type="EnsemblBacteria" id="AQT67456">
        <property type="protein sequence ID" value="AQT67456"/>
        <property type="gene ID" value="STSP2_00603"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00603"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31989" checksum="14D8A3781088B57C" modified="2017-06-07" version="1">MLKIATCQFAVTGDVDHNAGHIESFVRQAGEEGADLVHLSECCLSGYAGVDHETLEGFDWEHLRDRTRAIMELAKEKQVWVALGSMHELSAGNKPHNCMYLIGPDGKIHDRYDKRFCTEIELPFYTPGDRAVTFELKGVTCALLICFDLRFPEIYRDLYKRGVQFVIQSFYNARQKGPSVHTDIMRQTMQCRAATNFFWISMNNSSAWYSPYPSCFIRPDGKIVKELEWHRDQMMINEVNTDIELYDPMKDFRDIAVAGNLTNGPETIDDPRSKNVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX6</accession>
    <name>A0A1U9NIX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ORF">STSP2_00886</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00886"/>
    <dbReference type="EnsemblBacteria" id="AQT67737">
        <property type="protein sequence ID" value="AQT67737"/>
        <property type="gene ID" value="STSP2_00886"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00886"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="322"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT67737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="47957" checksum="2EE7AF1DA053D19A" modified="2017-06-07" version="1">MRIIALGINHKTAPVELRERLAFDEVAALSALGALKQQNPSGEFALLCTCNRVELYAAIKKDCDLAADDLLSTLAECKGIDASAIQPAVYVLEGVKTVRHLLTVASSLDSMVIGEPQIISQVKDSYRLACRNGFTGKVLNHLFHTAFSTAKKVYSDTSITSRRVSVAGVAVELAGQLFDKVASNKVTVIGAGEMSELLVEHFKQAGCKDISVVNRSPKRGRKLARKYSIEHHGWDQLGEQIRNASILVGAAGSDEGFLFDRDSFADLLSKRRKGSLLLIDIAVPRCFDPAINDLENAYLYSIDDLAGVAQKNVKFREEEVEKAVEMICEQADDFMEWFDIRDVGPVIGKLKHRFEQIQRAEMEKFFTNCSQEHVCRQSMETTVSRVVNKLTHCVIKNIDQVAREQGAADAARLAHRMLAEAEEIAAKAGDKEDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY0</accession>
    <name>A0A1U9NIY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">STSP2_00846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00846"/>
    <dbReference type="EnsemblBacteria" id="AQT67698">
        <property type="protein sequence ID" value="AQT67698"/>
        <property type="gene ID" value="STSP2_00846"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00846"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18719" checksum="D37952064BD4118E" modified="2017-06-07" version="1">MDLKQYIRDIKDFPVQGILFRDITPLLGDKDAMSYAIDAIAEPYKNKNVDYVAAIEARGFIFGAAIAREIGAGFIPIRKPGKLPCRSEAMTYDLEYGSNTIEVHADAVKPGSRVLMFDDLLATGGTMKAACSLMERLGAEIVATAFLVELTDLPGRLMLQKYPIYSVISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ9</accession>
    <name>A0A1U9NIZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67570">
        <property type="protein sequence ID" value="AQT67570"/>
        <property type="gene ID" value="STSP2_00718"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00718"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28450" checksum="A4C73E17C67131DF" modified="2017-06-07" version="1" precursor="true">MFKIKPSRTDMIVTLLCCAVLLAAMGAMGRGSKHAKTIVCQSNLRKLGQIATLYAQENDGEGFNSWYGRVDDYTAKAESIMHCSETKELVVDRTNMYTMGHSRKPWVWTWSLSSYVTGTYGYNGWLYTRSSYSSNEEKYFKNTCSVEKPSLTPMFADAKWVSSTPFVDDCIYPQTDLSGYPNQFYSTKISYFMMDRHYGATNIVFSDGHAESVALEEMWSLYWHKQWKPKHNVKRTDGTPIYRANSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ35</accession>
    <name>A0A1U9NJ35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_3</name>
        <name evidence="2" type="ORF">STSP2_00748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67600">
        <property type="protein sequence ID" value="AQT67600"/>
        <property type="gene ID" value="STSP2_00748"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00748"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="68"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="37188" checksum="4810C14BD3A45281" modified="2017-06-07" version="1">MERRDFLKRGVFTTGLLTMDNLNLFADPKNCPVRTERRPGFIPKRQYGKTDLMLSVIGFGGIVVMGHEQNQANRIVAEAFERGVNYYDVAPSYGDTEAETKLGPALQPYRDRAFLACKTTERTYAGAKEEFEASLKRLKTDHFDLYQLHAITDVEKDVDAAFAEDGVMKLLREEKKNGRIRYLGFSAHSHAAALAAMDRFDFDSVLFPVNFAGYLEGGFSPEVIEKAREKQMAILALKMLARQRAPKEDPVRRQYPKCWYQPITDPDEAKLAMAFTLSQPVTAAIPPGHVDLFRMALDAATELEPVTEQQMRKLKSWAAELNPIFSHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ40</accession>
    <name>A0A1U9NJ40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67744">
        <property type="protein sequence ID" value="AQT67744"/>
        <property type="gene ID" value="STSP2_00893"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00893"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27372" checksum="6F30098067E568B2" modified="2017-06-07" version="1">MTEDARTFDNACGSLANVTNLLREEFSESKCSAIAEAADTVARTPDELMPALCCLTAFQACATPDALEQKQTAVKLAAAMQALDMGLTIHENAFNDSYEQVDKDATYLIVLGDYLYSLAYQLICELKNTELMSLTADTVASVTAAALACEVNQQHDTRAAKQTAFRSYLYALCCGSAGILTNASQNTKAELSRIGTELGKAHDAVISNRPEKDITAHIRRARDAVNANKEILRIEPFYGLIDFIKSLAQQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ43</accession>
    <name>A0A1U9NJ43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00903"/>
    <dbReference type="EnsemblBacteria" id="AQT67754">
        <property type="protein sequence ID" value="AQT67754"/>
        <property type="gene ID" value="STSP2_00903"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00903"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039567">
        <property type="entry name" value="Gly-zipper"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13488">
        <property type="entry name" value="Gly-zipper_Omp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gly-zipper_Omp" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14539" checksum="1729474A0D1E635A" modified="2017-06-07" version="1">MFRNLGLATLVVILSAGVLMMSGCESKSQTGALIGAGAGAGIGQAAGGDTESTLIGAGIGGAAGYLLGKHQEDKQEDEDERDQTYRNIQSDTVTVWVTNSNGSKTPVTLEKENNGYVGPKGEFYETMPSEADLRKVYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ69</accession>
    <name>A0A1U9NJ69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase</fullName>
            <ecNumber evidence="4">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">axeA1_3</name>
        <name evidence="4" type="ORF">STSP2_01136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.72" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01136"/>
    <dbReference type="EnsemblBacteria" id="AQT67982">
        <property type="protein sequence ID" value="AQT67982"/>
        <property type="gene ID" value="STSP2_01136"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01136"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211447" evidence="1">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="272"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="499" mass="55751" checksum="00C02650B63A1090" modified="2017-06-07" version="1" precursor="true">MRKILWLALLLSLIVIPFTNAADQQPAKPRVLIIGDSISIGYTPHVKEMLKDKAIVTRPRTAKGHIINCGNTQRGLDNLTDWLGDTKYDVIHFNWGLWDICYRHPESKEQGRRDKKRGTITAAPEVYEQNLRELVDMLKATGARLIWASTTPVPEKEAGRFVGDEVKYNKIAARIMAENDIPTDDLYSYMLSVADKYYRAPGDVHYTDEGYRHLAKKVVSSIEKALDPEKIDLWPDTPPAQGANSKKVMPTITVYRTTREISKNAAVLICPGGGYGHLAMTHEGSTIAEWLNSVGITGVVLRYRHARDGDHFPAPLEDALRAMRIVRSNAPDWNIDPDKIGVMGFSAGGHLASMVGTKFNEPYGKAGDPADKLSARPDFMMLVYPVITMTQPFMHKGSKRNLLGPRANNDDLARAVSTELQVKTDTPPTFLLHCNGDKGVLPENSVAFYQALRKQNLDAEMHIFRKGSHGFGIRNLDNPIFDWPARAADWLDQILNAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ86</accession>
    <name>A0A1U9NJ86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Antilisterial bacteriocin subtilosin biosynthesis protein AlbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">albA_3</name>
        <name evidence="6" type="ORF">STSP2_00943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67794">
        <property type="protein sequence ID" value="AQT67794"/>
        <property type="gene ID" value="STSP2_00943"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00943"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="69"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="45599" checksum="40580527C8CEA63D" modified="2017-06-07" version="1">MKLRDWVLLTPIFLRCLGKLPLRHLLYLAKQFRNEQPKRHETGLHVNAFFPPYPSKAFDRFLDSVIERRRVPYSVYFAVTDRCPFDCPHCSYGMHQAGEMGTEEAVEVIEQIKSLGTPTIGFTGGEPLLRDDIVELVRACGDELASVMFTTGCGLDSQLADELRRAGLGCIMIGMESSDAGEHDAVRGVEGSFEQAIRTVELSRSAGLYTAVSTVATREKVRSGQIEKLARLAGEYGVHEFRVLEPVPTGSFCKQENEVLGSEESERLADFHKRWNRRNKGPAVSGFSYLESDEMFGCGAGFHHLFIDAVGNVCPCDLTPLSFGNVLDESLESIWLRMGETFELPRCGCLMKDICGQTYVLKNAQELPIDPERSLKVCEAVKKDGPLPKVYKNLLKGRKPVSRPENRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF0</accession>
    <name>A0A1U9NJF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68049">
        <property type="protein sequence ID" value="AQT68049"/>
        <property type="gene ID" value="STSP2_01203"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01203"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="231" mass="26353" checksum="E3BF305671D51B31" modified="2017-06-07" version="1">MIRPVITLRRRRVLIDVDTQKDFFLADGKAPIRNHRRVLINIRRVVAWARLKNVRMISTIWTPIDTSHQFCIPGTSGHEKLSYTTRENHVSFQADGSTDLPRDIFTRCDQIILEKRSPNPFDEPRADRILSELKADEYILMGALNEEAIKKTAIGLLARRKHVTVLTDCLGYHNKDTAEIANRQMEAKGAKLAESKTLLGASPLRLVQACDCDRCRGRMTKKNDAHEKSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU5</accession>
    <name>A0A1U9NJU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01240"/>
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        <property type="gene ID" value="STSP2_01240"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
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            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="415"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="435"/>
            <end position="452"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="490" mass="53448" checksum="FAF9AB0A9A10AE0F" modified="2017-06-07" version="1">MAEPQGAQQSSGNHETPSVPKHEAQQQSSDEFERQPVPEHALLKFKSFIGMYAGEHCAGTELMIGPLFVAAGVSVFDLITGLLLGNALAVLSWMLMCAPIATRARLTLYYQLERICGRHLVTLYNLANGIMFCFLAGAMITVSATAVGVWFDFPMPGLTDLYPNSIGWVLAVAAVGGVIAIVAACGYQVVAKFANIAAPWMVLVFLAFGLIGLRQFMNVSEAEVRNVGDLWALANNHIWKGGDPLPGQVKFTFWHVTFFAWFCNMAMHIGMSDLSVFRYAKKSWFAVASAAGMYVGHFMAWISASILFAYQLHLNPGDTNVLPGPMAYKAAGLAGLVCVIIAGWTTANPTIYRAGLAFQAIVHKWSRFTVTLVTGALATVAGMFPAVAMKLLGFVALYGMLLMPMGAVIFVDFWFMKKLGLQSNYAQISKSPFNLAAGLAWFVTLAVCWWLVQTGRIQIYFVSLPGWFFAAVVYVLISYLIQKRNCALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV7</accession>
    <name>A0A1U9NJV7_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68028">
        <property type="protein sequence ID" value="AQT68028"/>
        <property type="gene ID" value="STSP2_01182"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01182"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="311" mass="35015" checksum="B95B135E1E15648E" modified="2017-06-07" version="1">MELFVGIDVSKYFFDVCCGVDGKVSHFDYNQQAVAECVKMLERVEPTLVVLESTGGYELQLALAVQDSGLSVVIVNPSRVRSFGRACGKIAKTDKIDARTIAWYASALRPQVRGRINRKMCKLKTLTARRRQLVDMRTAERNRLEHVFEKAIRRSVEAVVKTIEREIGKVESAMAEHIDDDPQLREKVIKMRTVPAIGEVTASMIVSELPEIGSLNRRQIASLVGVAPMNRDSGLMRGKRTTGGGRKEVRTRLFMPTLVAIQHNPVIRKFYRRLLQNGKAKMTAVVACMRKLLTIINFMLAKNEEWKPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK06</accession>
    <name>A0A1U9NK06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">czcS</name>
        <name evidence="13" type="ORF">STSP2_01431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68273">
        <property type="protein sequence ID" value="AQT68273"/>
        <property type="gene ID" value="STSP2_01431"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01431"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sCache_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="397"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="614" mass="68693" checksum="2385757F25C5F057" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC1</accession>
    <name>A0A1U9NKC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68257">
        <property type="protein sequence ID" value="AQT68257"/>
        <property type="gene ID" value="STSP2_01413"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01413"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20709" checksum="EC5907B330F9D4A7" modified="2017-06-07" version="1">MCNRRESELSVILRLFTMTKSKEKIVWHFILLMVLFSCSSCERQQPNVRQTLENDYLRNSNETDVKVVRFAHIGKIESKGKSYYVIDLRTVLKGMPAPRGNNQILLYDNNLTKVASFQYDSMPLWCKGSRVYLFGVDTQEGMFGNVWDFSKGVNEGERRLIELPAYGSYKSEQTLGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ7</accession>
    <name>A0A1U9NKJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68462">
        <property type="protein sequence ID" value="AQT68462"/>
        <property type="gene ID" value="STSP2_01626"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01626"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="613" mass="67528" checksum="F2E4E75ED01A0538" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK0</accession>
    <name>A0A1U9NKK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbpI</name>
        <name evidence="3" type="ORF">STSP2_01494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.23" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01494"/>
    <dbReference type="EnsemblBacteria" id="AQT68335">
        <property type="protein sequence ID" value="AQT68335"/>
        <property type="gene ID" value="STSP2_01494"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01494"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="40361" checksum="7FF7C1BF74A24430" modified="2017-06-07" version="1">MKIINVVGARPNFMKIAPLMEAYNKNGQIEPLLVHTGQHYDEKMSDLFFRQLGIPEPDMNLGIGSASHAVQTAEIMKAFEPVCLEHKPDVVLVVGDVNSTIACGLVAVKLGIKLIHVEAGLRSGDRSMPEEINRILTDSISDLLFCTEQSGVDNLLAEGVEDDRIHMVGHVMIDTLLKNLEKAQKSNMLADLESRFGVNGDGYAVLTMHRPSNVDDPVVFSRILDALEVIQKDLPIIFPMHPRTRNNIAGTELGSRIEDMTNLHLLEPVGYLDFLKLTSSAKIVLTDSGGIQEETTVLQIPCITLRENTERPITAEIGSNQIVGTSTESILQAYSVVKSGQFRKPQVPPLWDGKAAERIVKALVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL44</accession>
    <name>A0A1U9NL44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lysC</name>
        <name evidence="16" type="ORF">STSP2_01831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01831"/>
    <dbReference type="EnsemblBacteria" id="AQT68662">
        <property type="protein sequence ID" value="AQT68662"/>
        <property type="gene ID" value="STSP2_01831"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01831"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="414" mass="44237" checksum="F8126CB406B0CB0D" modified="2017-06-07" version="1">MATVVQKFGGTSVADAEKIRRAAGRAIKAYNEGNKVVMVCSARGKQTDELIADAHELNPNPSKREMDMLLATGEQQTVSLMAMALDAMGHKAISFNGAQIGMVTDSAHSKARIQSIDAKRVKKQLDNGHIVIVAGFQGVDEKGNVTTLGRGGSDTSAVALAVAIGADVCEIYTDVDGIYSADPRKFPDAVKLEEISYDEMLELASLGAGVMHGRSIEFGKKYHVPIRVRSSLNDNPGTLITDEVPQMEGILVSGATIQKDLAKIGLLGVDNTPGTAAQIFAHLAGANVVVNDIIQVELSPDKANLSFTISHSDLEDAKKAINEIKKEVNCQSVFVREDIAEVSAVGVGMRSHSGVANAMFNALREAEVNVDAITTSEIRISCLVNEDQAERALVAVCKAFELDKPEEERTYNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL56</accession>
    <name>A0A1U9NL56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinitrogenase iron-molybdenum cofactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01807"/>
    <dbReference type="EnsemblBacteria" id="AQT68639">
        <property type="protein sequence ID" value="AQT68639"/>
        <property type="gene ID" value="STSP2_01807"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01807"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11950" checksum="6EEE9A0D100E8161" modified="2017-06-07" version="1">MRIAVPVSENVLSPHFGHCQEFALFCADENKKITAEERLAPPKHEPGILPQWLGGLSVNTVIAGGMGTRAQQLFTANNIDVVVGAPSQEPREVVEAYLAGQLQCGDNVCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL69</accession>
    <name>A0A1U9NL69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="2">4.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nanA</name>
        <name evidence="2" type="ORF">STSP2_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01851"/>
    <dbReference type="EnsemblBacteria" id="AQT68681">
        <property type="protein sequence ID" value="AQT68681"/>
        <property type="gene ID" value="STSP2_01851"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01851"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32714" checksum="6D73A17DAC5E7FD3" modified="2017-06-07" version="1">MNSRFSGILAAVFSPMDENGKVNTGVVPAIVDSLVADGVSGIYVCGSTGEGPLLAREERMEVAEAYTKACKDKMPVIVQVGHDSIAEAKVLAEHAAGLGADAVAAVPPTYFKCPSVENLVDCMAEISEAAGDAPFYYYHVPALTDGVFSMVDFLRLGEGKIRNLEGIKYSALTVFECQECLNYAEGKYNILFGCDEMLLSGLVVGVPGAVGSTFNFAAPLYNKIMDAYKAGDLERARELQLLSVKMVNTLFKYRGQPAFKAMMGILGVDCGPNRLPLKSLDSDEVAALKKDLEDIGFFDWGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL96</accession>
    <name>A0A1U9NL96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68340">
        <property type="protein sequence ID" value="AQT68340"/>
        <property type="gene ID" value="STSP2_01499"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01499"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012097991" evidence="1">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26963" checksum="79C887426C177FAB" modified="2017-06-07" version="1" precursor="true">MLFSKTKLLQSVCAVLVAVCGFCKADIVEYTGSLSTPGGIETLGSWDSATMDWTVTRDSSDSGIAGWWKYEYTFNITVQNEGQSAISHLTLERSVESSGIDFADFQYWVDGEAVGNITTEFVDYNATSNTDGVGPAAIKFETDDSDISDLGHEFRLSFYSRRNPVWGDFYAKNGKYSGQGQDALFNSAWNISMTDEGLIDYDPITPPSSGSLNSHILVPDTTVIPEPTSLMLAAFGMGLMRLRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB1</accession>
    <name>A0A1U9NLB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xpsE_2</name>
        <name evidence="3" type="ORF">STSP2_01683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01683"/>
    <dbReference type="EnsemblBacteria" id="AQT68518">
        <property type="protein sequence ID" value="AQT68518"/>
        <property type="gene ID" value="STSP2_01683"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01683"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="321"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="577" mass="64507" checksum="995E80B76C3EB213" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ5</accession>
    <name>A0A1U9NLJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68366">
        <property type="protein sequence ID" value="AQT68366"/>
        <property type="gene ID" value="STSP2_01526"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01526"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012052741" evidence="2">
        <location>
            <begin position="26"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="304" mass="34731" checksum="A7B4EAF4EA0C2654" modified="2017-06-07" version="1" precursor="true">MRLVSKILILMFCLCLWAPCGDILAVEESDSKSDPNSLVPDLFKEGYLFKGIEGSVKPVDEDARKWVFVTDEKIEGPRGELYAGDSLRLLPSSTLQRIIANQDKTDEIDVRLWARTANYAFPVKKNQRTYTGYDSRKPQRTQAARRENYLFPVYFLPLSSDEPAESNAEESTTKDNEKTDPGDDDSILPDEIRKALKPKKIVDLAKAKKTVDVEGDMMLINRTGVVRKQGKRYIFEVDALGRNVADLDFELLPCRALERMQRHMGDRPVKLRWKVAGIVTKFNGEYFLLPQRATRVYNNGNFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK8</accession>
    <name>A0A1U9NLK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sensor histidine kinase YycG</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yycG_1</name>
        <name evidence="8" type="ORF">STSP2_01857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01857"/>
    <dbReference type="EnsemblBacteria" id="AQT68687">
        <property type="protein sequence ID" value="AQT68687"/>
        <property type="gene ID" value="STSP2_01857"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01857"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="250"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="501"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="741" mass="83531" checksum="4316F5A473A910EE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM4</accession>
    <name>A0A1U9NLM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase cognate corrinoid protein, Methanosarcina family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01802"/>
    <dbReference type="EnsemblBacteria" id="AQT68634">
        <property type="protein sequence ID" value="AQT68634"/>
        <property type="gene ID" value="STSP2_01802"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01802"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27717" checksum="BE8EDC941B200CB3" modified="2017-06-07" version="1">MLKPNTLERYLDALLKGDRNLCRRVIEETLQSGVPANQVYMDVIWPIMVEIDNLYRRDVINSAQESFATRINRTLVDQLQNKLPRREAQQKKLVICCESTEQGELGGQMIADLFESNGWEVRFLGGCVKDDDVISFIQGYRPDILLMYGVDAKRAPHTRKLIDHIREVNAWPNMRIMLSGGIFDRAEGLWEEIGADLYASNPAEAVQIAGADESEIKQPERIINRRKHSTNDTKTAQKTAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN1</accession>
    <name>A0A1U9NLN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01644"/>
    <dbReference type="EnsemblBacteria" id="AQT68480">
        <property type="protein sequence ID" value="AQT68480"/>
        <property type="gene ID" value="STSP2_01644"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01644"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="414"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="590" mass="64441" checksum="13C5FDAC94D25F1E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN6</accession>
    <name>A0A1U9NLN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68644">
        <property type="protein sequence ID" value="AQT68644"/>
        <property type="gene ID" value="STSP2_01812"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01812"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="240"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="326" mass="36713" checksum="73BCDD2EBFE69E0C" modified="2017-06-07" version="1">MKRFMRGIKCRLRLTRCYLYDLARFKRHSGLLNSCHDRVLADITTTYHIIEKGLSFKDCRPGFGVKKVTKLMNLLTEFERTGGDTSRSQYKAACNVLKAYVGSGQIQSSDDTQLLVADIKSFLEGKPTDNCRFFAGGVRILSKTDCIEASRGDFRKLSQNRYSIRTFAGGNVPMSKIYDAVEMAQKSPSTCNRQTSRVYVYSKKNTINEILAIHKGTRGFTEQIDKFILVAGDQKCCLGVGDRNQVYVDCGIFAMSLLYGLQYNRLGACILHWNVTPKKDLQLRKVAGVADNHTVVCMIAVGRLAEEFKVPVSQRRNLKSICFAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM03</accession>
    <name>A0A1U9NM03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB</name>
        <name evidence="5" type="ORF">STSP2_02116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02116"/>
    <dbReference type="EnsemblBacteria" id="AQT68939">
        <property type="protein sequence ID" value="AQT68939"/>
        <property type="gene ID" value="STSP2_02116"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02116"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="29562" checksum="4AD3F59AF2008549" modified="2017-06-07" version="1">MAKRKPKQVKNKTQDKERLQKVMASAGVDSRRKCEDLILEGAVEVNGVMVNELPAFVDPDKDEIKVSGKRLKRPERVYFLLNKPRGYICTNKDPHGRKKAIDLIDTKERLISVGRLDAETTGALILTNDTGLANLLTHPKYELSKTYEVKLRGSVEGEDLEKLKKGLWLAEGRTNRAAVKVLSRTPKDTIVEITIRQGLNRQIRRMFARVGYKVKRLKRTKIGNIEMKGLPVGAYRTLTKSQVAYLKRVTAGRKGGRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM08</accession>
    <name>A0A1U9NM08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain/BON superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02041"/>
    <dbReference type="EnsemblBacteria" id="AQT68865">
        <property type="protein sequence ID" value="AQT68865"/>
        <property type="gene ID" value="STSP2_02041"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02041"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18708" checksum="F1FFE1F8A312E048" modified="2017-06-07" version="1">MLIRGPFLIIMPRDLKIGILIGFLFATAATVTVSMWPTEDLASRQKRAFEKNQSNNEITIDHSTYEMPADVDDKESQENSLKWGLSEDHPAVAEDDLFDSLDTTKRNSESANPKNEKVHVVTKGETLSSIARDYYGNQSKWKLIQESNDIDDPKAVRPGMELVIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM22</accession>
    <name>A0A1U9NM22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68784">
        <property type="protein sequence ID" value="AQT68784"/>
        <property type="gene ID" value="STSP2_01957"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01957"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8428" checksum="672AF39F642C0C91" modified="2017-06-07" version="1">MKKESVKVKVRRKHAKGETINSGTINWCKTIHSGLRKARQPVVSTMAHIPLGKMTASVRKRSISLGKRCLRKKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM24</accession>
    <name>A0A1U9NM24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scpA</name>
        <name evidence="3" type="ORF">STSP2_02159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02159"/>
    <dbReference type="EnsemblBacteria" id="AQT68981">
        <property type="protein sequence ID" value="AQT68981"/>
        <property type="gene ID" value="STSP2_02159"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02159"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="38150" checksum="1E5BB7EC15668602" modified="2017-06-07" version="1">MSELYRVDLDVFSGPLDLLLYLVRKDEVDIYDIPISHITEQYIHYIEMLKLLDIEVAGDFLIMAATLMEIKSAMLLPKASVEDGEEEEDSDPRAELVRQLLEYKKFKDAANLLESSAEDRSERHTRPDNILTELKQDAEPEVDLEQVSIWDLLEAFDGIMQATGRYADYSSIKDDTPIDLYQIDILHRLQSEGTMSFESIFAGKKNKLVMVGMFLAMLELMRNRLIWVEQSEKQGDIYVRPLTEDAAEEAVQRAIYERTVGEEAAENEQNATVGHADGQPEGAAENASVPAGEGGPGETEEEVNRDMIPIREYSPAQGREEPDEHMVAEGEESGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM26</accession>
    <name>A0A1U9NM26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01712"/>
    <dbReference type="EnsemblBacteria" id="AQT68546">
        <property type="protein sequence ID" value="AQT68546"/>
        <property type="gene ID" value="STSP2_01712"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01712"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34155" checksum="C4BD924F0BF0D47A" modified="2017-06-07" version="1">MKLVSFRQDGSESYGVLNERGVVDVPKMLTGPQPPETLLAMLERPDAVSRLGDIAQQASEVIPLSDVELLAPITRPGKLLALAGNYVKHIVEAGKKLGLSESPRKTTVPRPFLMPPNVLTATNTTIPLPCYSETVDYEIELTVVMGRTAKCVSPEEALEYVAGYTIGNDISARTVTFKEDRSERPWDEFFDWLNGKWSDAFFPMGPCLVTADEIGDPQKLDLELKVNGEVRQKANTKDMIFTVADTVSFLSHIMTLEPGDCIATGTPEGVGMASGVFLQPGDEIECSIEKIGTLTNLVGQRPDHKFKPCQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM62</accession>
    <name>A0A1U9NM62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68680">
        <property type="protein sequence ID" value="AQT68680"/>
        <property type="gene ID" value="STSP2_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01850"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="283"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="499" mass="55142" checksum="4A57A2887FA9940D" modified="2017-06-07" version="1" precursor="true">MRICVNVIILMVVTLAGVSAGAVRLPDIFGDHMVVQRDEELKVWGWAEHGEDVRVSFKGKVAKDTADAAGRWLVDLGKYEASCEPAELKVEGENTVVVKDVLVGDVWVCSGQSNMYFPLKRSANYEALKGSLDNKMIRLMRMVPGAYPSGRQFSDEELAKCVPVEYYEGGWERCSEEAAAEFSAVAYYFGAEIERHVGVPVGLVQNAVGGAPAEAFVSEGTLAEDEVLWDVCGDWLGSEEYAPWCRGRAKLNLGDTAGDAEQGHPFKPGFLFEAGIEPLTDFAVKGVIWYQGESNAPLTVVDESTDMVYNKRLLKTLIGDWRRAWGDSDLPFLYVQLPNMNRRWMEFRQMQLEVLREVPGVGMAVSIDVGDRRDVHPRNKRPVGRRLALIARAKVYGQDVVYSGPLPVDAVVEGAEVAVKLEHAEALQVRSGEKVRGFELVDSAGRWHEAEARIKSDKVFVLSDEVEEPSAVRYSWAPNPEGNVVNGEGLPMSPFIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM63</accession>
    <name>A0A1U9NM63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68596">
        <property type="protein sequence ID" value="AQT68596"/>
        <property type="gene ID" value="STSP2_01764"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01764"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="12486" checksum="97334A3A96D2280D" modified="2017-06-07" version="1">MAEKREKSGEKFVERRKSVVDRRLGLDRRRGPGIRRSLDRKAAEEGEMTDEQFQFLMAIDKYKRANQRPFPTWTEVLDVIKALGYRKVEEPCSLEDLKKQQESVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM91</accession>
    <name>A0A1U9NM91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Modulator of FtsH protease HflK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hflK_1</name>
        <name evidence="8" type="ORF">STSP2_02030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02030"/>
    <dbReference type="EnsemblBacteria" id="AQT68854">
        <property type="protein sequence ID" value="AQT68854"/>
        <property type="gene ID" value="STSP2_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02030"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="7">
        <location>
            <begin position="59"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="422" mass="47113" checksum="190284D855651373" modified="2017-06-07" version="1">MSDKDIKQNEAQIEAEEARPVENDPGMESLKNALAKTFVVLKVIMAFVIVAFIASGVFSVEQNERAIRLRFGAVTGDILEPGLHWAFPEPIDEIVVLPVTKSQTLEIDKLWYNETEREKLTGNKRRPGPTLNPLEDGYCLTRNENVVGSTGGDYNIVHSKWMLTYTIDYPEKFFRNVYVAEAKPGQDVLAVMQDSIEPMLEALTMDAITATLLQYTIDDAIVSKSSISEDAAMLLQEKLNDIDTGIDVESLRVAGQITWPRQVDQAFQRSNQAKQESDAMISQARGYARRILSETGGAGAETILADLQGDELDGEQRAELLTQLAGKSQEVIADARAHKTNIVEAAKANANYLTQLLPEYRKRPELVLQRIYQDAVEEVLDNAQEKIIVQPGKEGTDRQLRILINRDPARVRNNDDEQGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM93</accession>
    <name>A0A1U9NM93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01794"/>
    <dbReference type="EnsemblBacteria" id="AQT68626">
        <property type="protein sequence ID" value="AQT68626"/>
        <property type="gene ID" value="STSP2_01794"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01794"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="421" mass="47069" checksum="18E789E8313B5871" modified="2017-06-07" version="1">MLYYARGSETDNLSSADLQQGLVEALDKLGQREKVLAIPPDITRFYSRAGELTRHAWEYFGDRLTDVLPALGTHFPMTEDEIERMFGDMPKELFRKHDWRNDLATLGEVPAEFVRDVSEGKVDFSWPAQVNSLLVDGGFDLILSVGQVVPHEVIGMANHNKNIFVGTGGVEGINKSHFLGAAYGMERIMGRADTPVRRVLNYASEHFAADLPIMYIQTVIEATENGQAVRGLFIGDDTECFEKAAELSLKVNFQMLDKPIKKAVVYLEPEEFKSTWLGNKSIYRTRMAMADGGELIVLAPGLREFGEDPQIDKLIRKYGYVGTDRVLELVDENADLRVNLSAAAHLMHGSSDGRFGVTYCPGKITQAEIESVNFEYADCGQMMAKYDPTKLKDGWNSVDGEEIYFISNPGMGLWAHADRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA9</accession>
    <name>A0A1U9NMA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69061">
        <property type="protein sequence ID" value="AQT69061"/>
        <property type="gene ID" value="STSP2_02246"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02246"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="30545" checksum="F80995A22C2FAD3D" modified="2017-06-07" version="1">MKKVKLVRRIVVGVLAAVVILLIIFAVAGDGMIRRGVEKGASKTLDVPVTVGDLSLSLFAGSVDISDLDVANPEGFETPTLLEMGNADVDLDTPSLFSDTVTIDTMNFDDITLTIEQKGLTNNLKTVLDNLPKSEKGPEEPTEETKGKNLLIKKLTLSSVKVRAKLLPVPGQADTVELKLAPIEMEDLGTEDKMSVARLSALILTAIAEGVAQQAGDLFPADMVESLKGTLEELPFEQGQKLLEDTLKLGEDTLKNGSDAGKDIMEKGKDIGEGLKGLFDKKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB5</accession>
    <name>A0A1U9NMB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph</name>
        <name evidence="1" type="ORF">STSP2_02234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02234"/>
    <dbReference type="EnsemblBacteria" id="AQT69049">
        <property type="protein sequence ID" value="AQT69049"/>
        <property type="gene ID" value="STSP2_02234"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02234"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23547" checksum="6F77354D57FD7856" modified="2017-06-07" version="1">MNYKYILFDLDGTLINTLADLSNSMNYGLKQLGQPVHSHEECRKMIGSGVRKFAQQALPPTDQDLVDELLNLMRDHYRQNCTVDTVVYGGINELLAELDSICVPMAVVTNKDEDVARAIVRHYFGDRYFKKVAGAKDGVAIKPDPAVTLAIAEELGFSAEETLFVGDSDIDMLTGTACGMKTVGVSWGFRDSELLKQAGADVVVDEPAEIVELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF2</accession>
    <name>A0A1U9NMF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="8">FGAR amidotransferase II</shortName>
            <shortName evidence="8">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">purL</name>
        <name evidence="12" type="ORF">STSP2_02193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02193"/>
    <dbReference type="EnsemblBacteria" id="AQT69015">
        <property type="protein sequence ID" value="AQT69015"/>
        <property type="gene ID" value="STSP2_02193"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02193"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="11">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="9">
        <location>
            <begin position="284"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="411"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="9">
        <location>
            <begin position="674"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="790"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="960" mass="104879" checksum="280A124F3E00466B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG9</accession>
    <name>A0A1U9NMG9_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Heat shock protein GrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68706">
        <property type="protein sequence ID" value="AQT68706"/>
        <property type="gene ID" value="STSP2_01878"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01878"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="195" mass="22294" checksum="F30CA92CB7B76BBF" modified="2017-06-07" version="1">MRINKLLKQFLESATEEDVLKLAVRLDSEDKGDDFSQKIKPIESKLAQLDHKLSLLEANDKVLAQEMAQIRRLIEEYIVESSLKPLFVQVASLTMNLLKVNEGLVETDAESARRISVYLETFLEKLEKRVHLDLIIPEQGSEFDQDLHVAVAAVDTDRQDLHRKIAEVYKAGLIYKDKKLRPAEAAVFRYNSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR1</accession>
    <name>A0A1U9NMR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02399"/>
    <dbReference type="EnsemblBacteria" id="AQT69211">
        <property type="protein sequence ID" value="AQT69211"/>
        <property type="gene ID" value="STSP2_02399"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02399"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012617675" evidence="1">
        <location>
            <begin position="29"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="859" mass="96886" checksum="ABBBA9AD290C04F5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS2</accession>
    <name>A0A1U9NMS2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glgB_2</name>
        <name evidence="8" type="ORF">STSP2_02401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02401"/>
    <dbReference type="EnsemblBacteria" id="AQT69213">
        <property type="protein sequence ID" value="AQT69213"/>
        <property type="gene ID" value="STSP2_02401"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02401"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301703" description="1,4-alpha-glucan branching enzyme" evidence="6">
        <location>
            <begin position="24"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="139"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="677" mass="75801" checksum="7EA6D74F289A34CE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU3</accession>
    <name>A0A1U9NMU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mercuric reductase</fullName>
            <ecNumber evidence="5">1.16.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">merA</name>
        <name evidence="5" type="ORF">STSP2_02430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02430"/>
    <dbReference type="EnsemblBacteria" id="AQT69241">
        <property type="protein sequence ID" value="AQT69241"/>
        <property type="gene ID" value="STSP2_02430"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02430"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="344"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="708" mass="77702" checksum="C5DD2AE9EB0FF692" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV1</accession>
    <name>A0A1U9NMV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69127">
        <property type="protein sequence ID" value="AQT69127"/>
        <property type="gene ID" value="STSP2_02314"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14544" checksum="84A36557B3137092" modified="2017-06-07" version="1" precursor="true">MYDKSLTMLLIVLIFCSPFAGFAVLCHGSDGHVAIEAPGHDHCHCAESDSAGGDHAAEHNGSTIASSHDHCNDSLLTADAIAHRLKLSKTFSQTAESAPLRSYLNAYSQACAVTVPKPRSGLFRYHEPLQSVIIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV8</accession>
    <name>A0A1U9NMV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68940">
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        <property type="gene ID" value="STSP2_02117"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="40204" checksum="E3A81A346E1DB3C9" modified="2017-06-07" version="1">MDTEFHKQISLSFGGVLLRFTLLLLSFTCSLHAFAGRFEPGFKTGTVRCDYMNELSGLAAGRVNNAVLWSHNDSGDTARVFAISPAGECLAIVTLAGVKAADWEDISIGPGPQNGKTYIYVGDIGDNGENRPFVTVHRFLEPAIDPNAVSTPLKIQVKPESARFKYEDAPHDSEAMWVDPTDASLYFVTKRTPVARIYQGKWPKKPGKTTQTLQTPDESKQNPDKSDENTQTVQKPDENKHTLDRSDKSTQILHKVGSIPMKWVTAADISPSGNQIIIRNYNQAMLWHRPEDENIADALAKSGQLVPLEAEKQGEAICFAADGKGYFTVSEKKRQPIYYYACKGVRRDSKATGSAGGESASGKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW6</accession>
    <name>A0A1U9NMW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor YlaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ylaC_1</name>
        <name evidence="4" type="ORF">STSP2_02450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT69261"/>
        <property type="gene ID" value="STSP2_02450"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02450"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="200" mass="23781" checksum="F1014D333939DB36" modified="2017-06-07" version="1">MRTLQQKREYVGVIDKARNGDQHAMEQLIEMIRRRVWPFIYKRVRHEDIAADLMQETYLAVLRKLPELDNTRGFWQWVFTIARSKIIDHIRRRNVRDLTWFSAIDSAQLEDLMSDKYISPASDMAFDEFMLAFQQARSRLHGRARRIFTMRMDLHMTYEDIADDLGCTIPAARVAFMRARKQIAEELTHNCGYGPCEKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ4</accession>
    <name>A0A1U9NMZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69322">
        <property type="protein sequence ID" value="AQT69322"/>
        <property type="gene ID" value="STSP2_02511"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02511"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="196" mass="22597" checksum="E27CA1896D2AB2D5" modified="2017-06-07" version="1">MALQPSRYFLSKRKWCRKDIATKVDHITTANTRIYYYNDNWQVLAEYDGSDSFKRYYVYGNYIDEPLMTSDSTTDLYYAHDHLYSTAALIDTAGNIVDATNTSVASTHPPPLNAHQLPRQRLMYPPVRRHRLERPTLLTARKITDNPARYPSSCHPDFMNFSIAFGLSLFWKACRAGSFVFFILFSSSSRIARISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN04</accession>
    <name>A0A1U9NN04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69215">
        <property type="protein sequence ID" value="AQT69215"/>
        <property type="gene ID" value="STSP2_02403"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02403"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012278990" evidence="2">
        <location>
            <begin position="23"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="350"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="707" mass="75959" checksum="76989BF58A9C52A2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN10</accession>
    <name>A0A1U9NN10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-rhamnose-H(+) transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rhaT</name>
        <name evidence="7" type="ORF">STSP2_02374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02374"/>
    <dbReference type="EnsemblBacteria" id="AQT69187">
        <property type="protein sequence ID" value="AQT69187"/>
        <property type="gene ID" value="STSP2_02374"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02374"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015153">
        <property type="term" value="F:rhamnose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004673">
        <property type="entry name" value="L-rhamnose-proton_sym_RhaT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06379">
        <property type="entry name" value="RhaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0769">Symport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38383" checksum="697E7BB02A8B5FC2" modified="2017-06-07" version="1">MIPANPIAGGTFHGTGAMLAANCYAPQKFIRRWSWETFWIVQASFCWLILPVVGAYLTIPKLGTVLGEAIESHRLPLLLSFGFSLAYGVGGIAFNYSIRYMGFALTYAVAIGLSSVLGTIVPPLVRGQLIDTLTNPGAMWVIAGIGAGTLGIACCGYAGRLKERGLVEREGGKGEFSLTRGLLLSLLAGVLSAFYAFAIEAAAPVIELAAAHGAGHWQGNVAYLTANTGAFVTSAVYALMLARKNRSLGEFVTLPQGKGKASLLVNYMLAALVGTLWYGQFFFYNLGHVRMGQYAFTSWAVHMTMLVLFSSLTGLLFREWKGCSRRTVVWIILGVTILLSSVMMLTYGNYIGSEAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN78</accession>
    <name>A0A1U9NN78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH:ubiquinone oxidoreductase 24 kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02154"/>
    <dbReference type="EnsemblBacteria" id="AQT68976">
        <property type="protein sequence ID" value="AQT68976"/>
        <property type="gene ID" value="STSP2_02154"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02154"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9306" checksum="0A7FDE37E4F06E87" modified="2017-06-07" version="1">MEKVKVEICTGTTCYVMGASEVAGLEELLDEKLRPAVQIKGSPCFGLCKDLQYRGAPYVKVNDVLIEEATVEDVVREIKKQLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ0</accession>
    <name>A0A1U9NNJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hom</name>
        <name evidence="19" type="ORF">STSP2_02487</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02487"/>
    <dbReference type="EnsemblBacteria" id="AQT69298">
        <property type="protein sequence ID" value="AQT69298"/>
        <property type="gene ID" value="STSP2_02487"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02487"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="355"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AQT69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="442" mass="47622" checksum="7221C2B38668EB55" modified="2017-06-07" version="1">MANKVKVGIVGFGTVGTGVAKILLENNDIIKSKSGIDVELVSVVDMDTTTPRPLSLPQGMLSSNLADVIDNDSISIAVELIGGTTVAKDIVIEMLRSGKHVVTANKALIAEHGTELYKVARENNRCIAFEASTCGGTPVIGALRTGLAANQVNALYGILNGTCNFILSNMTDNDIDFPTALKQAQEKGYAEADPTLDINGADTAHKLTILSRIAFGRQIEFSDVYFEGIENTSIVDIRYGRDMGYTLKLLAIAERDPETDKISLRVHPAFIHDDHPLAQIEGPFNAVSVIGHAVGQTMYYGRGAGMLPTASAVVADIIEVALGNSEKLFNGQTLQSREETLEKIDPIENLTTRFYVRVMAKEQPGVVAAYSKILGDHNISISGVLQREEAEHSNIVPVVIATNATKQKNMTAALQEITDLDVITETSTCIRIVDIPEDDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM1</accession>
    <name>A0A1U9NNM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02303"/>
    <dbReference type="EnsemblBacteria" id="AQT69116">
        <property type="protein sequence ID" value="AQT69116"/>
        <property type="gene ID" value="STSP2_02303"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02303"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_92N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="1">
        <location>
            <begin position="270"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="768" mass="87414" checksum="A2CBFF5D44C0B7B2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM5</accession>
    <name>A0A1U9NNM5_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase of the TIM-barrel fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT69328">
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        <property type="gene ID" value="STSP2_02517"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02517"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="41"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="28603" checksum="21994C1A16F35553" modified="2017-06-07" version="1">MITDCHTHIANPTNKAEIEGHLEACSSADACIVLGSVENSIPDYNKQLGEYCKSHKKMTGFGVINPVEDPVKSRAVKNRIRDAGLAGIVLYCSEHRFHPAHSRAMRLYEAAEKLNLPVFFHNSAPYSSGAIMDYGRTFLLDEIARRFPSLKIIIGGMGVPFASETICMISKHDNVFADLTFRPNRVWEVYNLVVTAYEADVMDKLLFGSGYPLSGVNECVETLLGFNRLMADTHLPVVPRQELRNIIERDAFALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN2</accession>
    <name>A0A1U9NNN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CzcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">czcC_1</name>
        <name evidence="4" type="ORF">STSP2_02313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69126">
        <property type="protein sequence ID" value="AQT69126"/>
        <property type="gene ID" value="STSP2_02313"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02313"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775674" evidence="3">
        <location>
            <begin position="16"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="451" mass="50063" checksum="DCB3D26CD51CC5E4" modified="2017-06-07" version="1" precursor="true">MRNFFICNMLAAVFAAGCMGQTAPNDPVAAGRTVKDACKNINIDSAVSFEEPRGELTLARALGLTLVQNPELKSFSLEVRAAQARQLQAGLTPNPELEIEVEEVGGTGESSGFDAAETVIVLSQVIELADKAQKRSDVAAFDKKIAASEYRNKKLELFSDTTSAFIAVLRAQEKLELTRELLNLSKASYDAVRKRVAAGRDTQIESDRAAIELENLKRELGQAERRLESARSRLAHFWGQPKATFSTALGDLEEITELPALEALEKQLPETPEYARWKQMVNKSRAQLKLEKARAVPNIAIGAGMQRFNETDDNAFLFGVSIPLPLSDRNQGSIKEAVYNLGRTRYQQTAAQIELHNELIQAYQELANAHAQVISLRDEILPRAERMFQTSQKAYNAGKIDYLNVLDAQRTLFDVRSEWLESLAEYHLAKTEIARLTGTETSSENLSDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ9</accession>
    <name>A0A1U9NNQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69543">
        <property type="protein sequence ID" value="AQT69543"/>
        <property type="gene ID" value="STSP2_02735"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02735"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21029" checksum="845B59CA25DBF5DB" modified="2017-06-07" version="1">MMLNPVETPWLAVGIAFAVWVIIVSRSVFGGMEKRWWHYVVVLAIVAAGIGVDYLLDSDMEAINKQLEAGRTAVIESRPGDIADLLARDYSDAVHGSKAEFMARCRSVLDRRAVEDIDFGKKVIELDGRHATVELGVFGKPAKGTGYADIAPVFRVEMELELAKNGGEWLIERAELVKVNGQSVSWTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP29</accession>
    <name>A0A1U9NP29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_5</name>
        <name evidence="8" type="ORF">STSP2_02549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69360">
        <property type="protein sequence ID" value="AQT69360"/>
        <property type="gene ID" value="STSP2_02549"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02549"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="676" mass="73316" checksum="994EC9CB19CCAF50" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP34</accession>
    <name>A0A1U9NP34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">STSP2_02868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02868"/>
    <dbReference type="EnsemblBacteria" id="AQT69673">
        <property type="protein sequence ID" value="AQT69673"/>
        <property type="gene ID" value="STSP2_02868"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02868"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="383" mass="42576" checksum="527D0EE52C888240" modified="2017-06-07" version="1">MEQLVTSDFKLGIIAGGQLGKMLALAASRWDVKTYILDSDDHCPASTVCTRFVEGDYRDFEKVYEFGQQVDMVTFEIENVNVEALRKLKQEGKRIYPDPEVLAMIQDKGVQKQFYLEHGIPSPAFVLCDGREQVIKSIGEGVQFPFVQKARKAGYDGKGVVVVRGEGDLGKLLDVPCVVERAVDIDKELAVIVTRNGRGEMACFSAVEMVFNPEANLVELLVSPAEIDADVQDRAIELARQVTEKSGIQGVLAVELFLDTDGELWVNEAAPRPHNSGHHTIESAITSQYEQHLRAIFNFPLGSTDLKRPAVMMNLLGDREHEGPVRYEGLTESMAIPGVKVHIYGKKETRPFRKMGHVTIVSPTTDEAKKHAVRVRDLLKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP77</accession>
    <name>A0A1U9NP77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69410">
        <property type="protein sequence ID" value="AQT69410"/>
        <property type="gene ID" value="STSP2_02599"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02599"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="23420" checksum="F66CB6888A7A6880" modified="2017-06-07" version="1">MKKPYSLLAFGTLMVLASIPPALFFDYAHYYTFFSIGMLLVMMGLYELQTDRGLFSSWKPRQHIVFWGGTIAVCIFLDQFGLDAGYWHYPWYSNVFDEILKYVFEWAVPFVYLGFGLLIGENFLHKRGVGRVTAFLVSLLVFVTALGIFTEFFNLYVYSWKITDMPFTDAKVGGFFVMFQTFGFWAMAIIGYSKHALIRRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB9</accession>
    <name>A0A1U9NPB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ispE</name>
        <name evidence="10" type="ORF">STSP2_02841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02841"/>
    <dbReference type="EnsemblBacteria" id="AQT69647">
        <property type="protein sequence ID" value="AQT69647"/>
        <property type="gene ID" value="STSP2_02841"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02841"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="301" mass="33822" checksum="86F9CABDBEE1B3A8" modified="2017-06-07" version="1">MSPEFKEQFEDIEGGVVVRAPAKINLSLLIAGKREDGFHEIETVMAKVNWYDELLIERIESGIELFCEGPYWAPEGPENLVWRACRRVFDEAGVEYGVRFTLRKNIPAGTGLGSASSDCAAAVMGLDRLFDLGLSRGQQMRIGGELGSDVPFFMGGPVAYCTGRGEKIDEKRCNFFFKTILLLPDVTVSTKKVYENYHHDEDEYRRLHGEISQYIAENRIDLLGSICENMLAASCFDLYPRLSDLKSRSGSLGPGRVCLSGSGSAMYCMVTDVEEHEIEDFQSMLRERMGCESLLLYSNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE4</accession>
    <name>A0A1U9NPE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation efflux system protein CusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cusA_2</name>
        <name evidence="2" type="ORF">STSP2_02671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02671"/>
    <dbReference type="EnsemblBacteria" id="AQT69480">
        <property type="protein sequence ID" value="AQT69480"/>
        <property type="gene ID" value="STSP2_02671"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02671"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1255" mass="138072" checksum="F7591A3F36C40FF0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF4</accession>
    <name>A0A1U9NPF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c551/c552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69789">
        <property type="protein sequence ID" value="AQT69789"/>
        <property type="gene ID" value="STSP2_02986"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02986"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="62" mass="7155" checksum="9F0747139DA04F80" modified="2017-06-07" version="1">MKARYPGKVFGDYFPLAWCHQFDGGRQFYTALGPPKHYKDKNSINHLTGTLKWTLNPKSTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR2</accession>
    <name>A0A1U9NPR2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="2">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mltA</name>
        <name evidence="9" type="ORF">STSP2_03103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03103"/>
    <dbReference type="EnsemblBacteria" id="AQT69903">
        <property type="protein sequence ID" value="AQT69903"/>
        <property type="gene ID" value="STSP2_03103"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03103"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012775678" description="Peptidoglycan lytic exotransglycosylase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="MltA" evidence="8">
        <location>
            <begin position="147"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48211" checksum="1301E2A25370C9DA" modified="2017-06-07" version="1" precursor="true">MRRKGLLVVLALMGLLFAGCQQDQVVEEDEKDYEKPLPPGQLALRKITDPSQIPDFTIAACDTSNLRSAIKNSLNYMAKPSSQQFFPYGDISHRKVVASLQEFVNMLDSGLSGRELAAAIKRKYDVYISVGCDNMGTVLFTGYYTPIFDGSMKRTARFKYPLYSKPDDLVKGANGEILGRRTANGSIVDYPSRTDIEASDMLEGNELVWLSDPFEVYIAHVQGSAKIRLPDGKLITVGYAATNGHKYQSVSKQMLKNSAIPADKMSLKAMIDYFKVHPEEVDDYVSQNPRFVFFQISRGAPRGSLNEPVTPWRTIATDKSVYPRASLVFMSSKMPRSIGGRTVTSNYTGFVLDQDTGGAIRAPGRCDVYLGQGEEAGRLAGQVYHEGKLYYLFLKPEHMPSNVFASPDDSSGAGTGGSSNTWRSRSQSQQREEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU5</accession>
    <name>A0A1U9NPU5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="1">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nnr_1</name>
        <name evidence="1" type="synonym">nnrE</name>
        <name evidence="3" type="ORF">STSP2_02727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02727"/>
    <dbReference type="EnsemblBacteria" id="AQT69536">
        <property type="protein sequence ID" value="AQT69536"/>
        <property type="gene ID" value="STSP2_02727"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02727"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="1">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="25432" checksum="AF252D0610ED3C9F" modified="2017-06-07" version="1">MAKVFNVRKYSPGDSVLSREEVRKFDEWAIEQIGVPSCVLMENAGRGCAEVILEHLGDVENPKVCIFAGIGNNGGDGFVIARHLADAGCDVKVVTCGDQSKIKGDAKTNLDIVCKMEIGVFQLDMGLYGLDKRVEHFAKDSDIIVDALFGTGLKGALRGNYPELIDDINKLGKSVVAVDIPSGLNCNKGVPTEKQLAIKANFTVTFAAAKRGFTSTASREYTGDVYVAGIGIEPVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX1</accession>
    <name>A0A1U9NPX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC, inhibitor of MCP methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03184"/>
    <dbReference type="EnsemblBacteria" id="AQT69983">
        <property type="protein sequence ID" value="AQT69983"/>
        <property type="gene ID" value="STSP2_03184"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03184"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17080" checksum="CC73E84EBC95F6EE" modified="2017-06-07" version="1">MIAEKTLTEPLWQAAEEAFKCMIMLDLDRVDKLEKLDENTPRMVGSITFMGALQGAVVVQCDLDTARMVSRSMLMMGAEDEISDEEVEDALGEVVNLVLGGFKSRIANDLGEIQISVPMVIQAKDPSPGAGTGGEVADVFVKSGEHELQMSVVYKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ6</accession>
    <name>A0A1U9NPZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69979">
        <property type="protein sequence ID" value="AQT69979"/>
        <property type="gene ID" value="STSP2_03179"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03179"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26698" checksum="2FD2DD29EA0D5C56" modified="2017-06-07" version="1">MNRSAMIIWFVIMGMLCSLGGFLGGVLTTRTTQSEIGARMADADKTAVKLDKLRRANTRLEAKQDILVEKTWELGRFAGRIESFARLRNSVCEYFKPTDDDPIDHVKDMMSRPETKNAARLCIGLFSILEPKIDELEQEVTNWGGSHFDNNLSMVAGNLQTAAFWEAKKQSDIVKLLNNSNVWLMSVYTASESADESLAESIETAYDGVVSVWDDKVPGYPETEPLPESLVPPLSVSAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ06</accession>
    <name>A0A1U9NQ06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69798">
        <property type="protein sequence ID" value="AQT69798"/>
        <property type="gene ID" value="STSP2_02995"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02995"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="149"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="529" mass="58398" checksum="B20E426310629D2A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ21</accession>
    <name>A0A1U9NQ21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03233"/>
    <dbReference type="EnsemblBacteria" id="AQT70031">
        <property type="protein sequence ID" value="AQT70031"/>
        <property type="gene ID" value="STSP2_03233"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03233"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011453">
        <property type="entry name" value="DUF1559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07596">
        <property type="entry name" value="SBP_bac_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30321" checksum="6F8355AEA1CBDA15" modified="2017-06-07" version="1">MKKSGFTLIELLVVISIIALLLAIMMPALGIAKERARRIYCSANLKNLSMAWFTYQSENGGKLVGASTVNGADGDWVSLPEDNDGNKIYRDDWDYTDVSVEYKQNGIEQGTLWEYSKNLGSFHCPSDKRDKDPSQQAWRSYQIQTNMNGQSYGPLADTEDIVSRFTQIRNPSSKYVFVETTDWRGMNLGSWRILPNTDERMWRDPLSVRHGSYGCFGFADGHAESHKWVEESTFEMSETQKHSTRLHEDEEGVDLEWARKHAGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ27</accession>
    <name>A0A1U9NQ27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pdhC_3</name>
        <name evidence="8" type="ORF">STSP2_02810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02810"/>
    <dbReference type="EnsemblBacteria" id="AQT69616">
        <property type="protein sequence ID" value="AQT69616"/>
        <property type="gene ID" value="STSP2_02810"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02810"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46512" checksum="D102130CC67761A0" modified="2017-06-07" version="1">MAEKVPMIALSPTMEDGHIVKWVKEEGEQVDTGEVLCEVETDKATMEYESTFEGTLLKIVVPEGESAKVGQMIAVIGEEGEDISELLKEEPSEPEEKEKTEAQKQEPEETAEEEPIEEGAEEQTEPKEQKEEPKEKPKPQPAAAKTKSSPLARKIAQEHGIDIEQIEGSGPDGRVVEADVKKAVEQGTTGKTAPAAAAPAEFTEKTEKVSQKRWLIAKRMTESKFSAPHYYLKVSVQMDDLMASRSRINEKLDGKISLNAILLKLIAQTLTKHPTVNASWNDDSITMHGRVDIGVAVAQKDGLIAPVVRNCETKTIRQIDSELRDLIDKARTGSLSSGSYSNPTFTISNLGAMGIEEFTAIINQPASAILAIGQITPTPIINGSGEFDAAKIMKLTLACDHRVIDGAVGAAFLSELKQTLENPLQAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ71</accession>
    <name>A0A1U9NQ71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70082">
        <property type="protein sequence ID" value="AQT70082"/>
        <property type="gene ID" value="STSP2_03284"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03284"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="17115" checksum="C3EFE544C57449D2" modified="2017-06-07" version="1">MPTKRSDWRTEPMPDEHAVIPYSQRFTPAEHDKLKQGYMPRQQEDKWFIYLKDDTICFHRSWTGFCMYKVELTRQEDGSYTVSQAVVNRCRDQYTETDDAKDVQILATLVNSFLLHKGLPSPGETDALKGWSMFGRAITGDDEQLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ78</accession>
    <name>A0A1U9NQ78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69770">
        <property type="protein sequence ID" value="AQT69770"/>
        <property type="gene ID" value="STSP2_02967"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02967"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15150" checksum="CE59293628E90586" modified="2017-06-07" version="1">MYGRVRKTGRCRGGRRCRGGFTLTEVVVASTLLLLGITPILKALTGSYISSTRIDQKTQSLLLAEAKLDEVKDAVGADHAASVVQSDLQLQDGFYCDIADDTVNSGLRELSVSVGVDADSNARLDDDEVLVSLSTMVARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA5</accession>
    <name>A0A1U9NQA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70089">
        <property type="protein sequence ID" value="AQT70089"/>
        <property type="gene ID" value="STSP2_03291"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03291"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16683" checksum="7F74EF585B5733BC" modified="2017-06-07" version="1">MPISELRLIKNCAEYIPISDISRIPGRTRGIYVLYNHDPKSKMYDVVYIGMAGGEKKASIRGRLRRHRSKKSDEWTHCSVFEVWDNIREEEVRELEGILRHIFRKDQQANKLNQQKAFMKLKHVTAHTKQSDWLLSESNGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH3</accession>
    <name>A0A1U9NQH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70183">
        <property type="protein sequence ID" value="AQT70183"/>
        <property type="gene ID" value="STSP2_03388"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03388"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22790" checksum="25197A9F2900F127" modified="2017-06-07" version="1">MNDRESQLNELFDKISDEPSGRAKHKEALRSEMLERFEPAAIRLRPRERFHKRAKRAILSPATAGLAACVLALLIGHQLATRFVWDTEPAPSLDSAGGVSLKYDFMPSARLKEAETEVGYEDSVDSENGRLEEMLQSKDIDGLVEILQNGSFGDKIAAAKLLSDMGAQEALPELERLGSEWQGGEPNPFSTAAEVIKSSTFDPTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR1</accession>
    <name>A0A1U9NQR1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplP</name>
        <name evidence="9" type="ORF">STSP2_03044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03044"/>
    <dbReference type="EnsemblBacteria" id="AQT69846">
        <property type="protein sequence ID" value="AQT69846"/>
        <property type="gene ID" value="STSP2_03044"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03044"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15870" checksum="2DD76717F45F95A0" modified="2017-06-07" version="1">MALMPKRVKYRKKMRGKMRGNASRGNYVAFGEYGIQALSHHWITGRQIEAGRIAATHFLHRQGKVYIRIFPDHSYTSKPLEVRMGKGKAEVEGWVARVKPGTVLYEISGVPEDVAKAALARVAHKMPVRCRFVTRRHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU0</accession>
    <name>A0A1U9NQU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03485"/>
    <dbReference type="EnsemblBacteria" id="AQT70279">
        <property type="protein sequence ID" value="AQT70279"/>
        <property type="gene ID" value="STSP2_03485"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03485"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30018" checksum="1AEE4A501EED7CC8" modified="2017-06-07" version="1">MRLRKGFTLIELLVVISIIALLLAIMMPALGMVKEKARSVVCRTNLKQLYLGATVYASENGGKLVQYDVQQNGTPARLWISRMSDYVGDVDESRYCGSAKVDESASAGSIGTARKCWAVNVLSNSASQNSGQYNGDGDSSGQGYETECGSYAYNGWLYSPDQNGNVGADTSKSYRGKLYGIRQSASVPMFADAIWYEAWPLAGETIDKNSFNFDDGDAGTSMGRLMIDRHGMKSNLVFADGHADSAGLAEFWSFKWNRGFRTTSEEWGDSERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU3</accession>
    <name>A0A1U9NQU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deoxyribonuclease YjjV</fullName>
            <ecNumber evidence="2">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjjV</name>
        <name evidence="2" type="ORF">STSP2_03508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70302">
        <property type="protein sequence ID" value="AQT70302"/>
        <property type="gene ID" value="STSP2_03508"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03508"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="30180" checksum="BE8C922494D83361" modified="2017-06-07" version="1">MTKTRQQNLTDCHLHLQAFTDDLDAVLDRARAAGVSRYICNATQPSDWPAVKQLAATHPDMIPAFGLHPHFVTDQPENWLDRLEQYLTATPSAAVGEIGLDRHFTRETFQAQRTAFIAQLDLARKLDRPAMIHCLRADGPMIDILTDQPKQPRPILMHAYSASAEMLPRFARLAAYFSFGGAAIRQNAKNAHHALTAVPDDRLLIETDSPDMTPPKKYQSADIPNPDRNEPANLPHILTRIAEIRNTDPEKLTEQIARNTEKFLASLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR42</accession>
    <name>A0A1U9NR42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70214">
        <property type="protein sequence ID" value="AQT70214"/>
        <property type="gene ID" value="STSP2_03420"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03420"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6706" checksum="C5196839719588B4" modified="2017-06-07" version="1">MPVAKRAENSDLQAVSKLFCRLFESNRRLFDQQIVKTHNKSLLVMSSKNTSTQFYGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRD9</accession>
    <name>A0A1U9NRD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70337">
        <property type="protein sequence ID" value="AQT70337"/>
        <property type="gene ID" value="STSP2_03543"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03543"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029468">
        <property type="entry name" value="O-ag_pol_Wzy"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14296">
        <property type="entry name" value="O-ag_pol_Wzy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="498" mass="56589" checksum="17D468A7F683FB7C" modified="2017-06-07" version="1">MNKSTTEIFRVQALTKTSWLYQCWLFFTALLSGVVYGMLHESPQATVKYMVAVYYLIFALHVLHRTKCFRQQANVLSPDILFSILYTLFHLGYITLYALNIVPYESDIIFYKASISKALFVINLGFIGFLSGYEFAAPKMLDFSVLQKPRRIPKQGWLLAGVSLIITSIVMHYGVLLVLGLSIFKSHGYTAVQNLDRYVDSYLINLLWSQNVHVMVLGITIYTAASALRYGKLFYSKFVTVLVSLFLFTIILEGNRGPILMILIPILLVRHYFVRPISLKILVVLAVLLLFVFAAIGVVRTIAFEPEKMMEELEYQAQSEQLTWANPFIEMGGSFLVVNITTHEVPEREPFWHGASWRDAIIHFVPFLSRYTLASGISTWSPSVWITTTFFGKESAGRAFTVAAEGYLNFGFVGAFAELFLLGVFARWLTVKFSRNPSMFWALIMLGCLGPIMMVIRNHLALLTHKITLVVIIAIVIQLFIGDEPVESYDMDLESYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRX6</accession>
    <name>A0A1U9NRX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70350">
        <property type="protein sequence ID" value="AQT70350"/>
        <property type="gene ID" value="STSP2_03556"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03556"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="24848" checksum="96E7163A4D1F675F" modified="2017-06-07" version="1">MKKLAVTLLISAFIYGCSTEDELTISKQESCRWKCNLQSGKALEIEMLLFPRSEFPEQRFSELKTLQENELEHQRKMIKSAPTAELQRSYSEEVRLREAGQWPWKLTGDWNDWPIVFIEPVLLTTSEITKSLVLCRYENYRNDIVFKIYGLGEVDYKTQLECIEQLTEELEQLTANQWAELPVSSTPLYNQDGVIVNPDLIDFFEGSIFPKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH0</accession>
    <name>A0A1U9NGH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67032">
        <property type="protein sequence ID" value="AQT67032"/>
        <property type="gene ID" value="STSP2_00170"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00170"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15113" checksum="9612997872BF22B8" modified="2017-06-07" version="1">MALNSDKLKLAVQIVLIALSAAWLTPAAVIFLPWAWFEPVIKDYGIAGNPSPLQKYWFVMAGAISGFAGGVIISLVKRVEEKIHFVKAVAYFHIGLAVILLTRGLGLNAPVEIVLWDSFFCALTGLVLLAASSRMVAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH8</accession>
    <name>A0A1U9NGH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67039">
        <property type="protein sequence ID" value="AQT67039"/>
        <property type="gene ID" value="STSP2_00178"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00178"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9946" checksum="66059D9D3719770E" modified="2017-06-07" version="1">MKYDRLKFIAGLAVLNVGAFLTTAMFLPQRGGIYRYSSKLELWFIRRHDWHIAWGVLLATLTVSIAGWLIVEAFCEKGRSGEDRPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ8</accession>
    <name>A0A1U9NGQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66938">
        <property type="protein sequence ID" value="AQT66938"/>
        <property type="gene ID" value="STSP2_00076"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00076"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19724" checksum="AEA9D87F901225F9" modified="2017-06-07" version="1" precursor="true">MRSVISIAVIAVSLVLTGCAEMEKPVEIRLTEPAKPAQATTERQRFDGATAQQEAQAASQVYTTRILTEENKELRKQIDELTAEKEALMEDNQVLEKRAVLLKENLAQTEKELEEANELLIDMRMELDKWKENVLGYREELRTVHTEQLRALAKILKLMGAEMVQQEQQSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU4</accession>
    <name>A0A1U9NGU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67161">
        <property type="protein sequence ID" value="AQT67161"/>
        <property type="gene ID" value="STSP2_00304"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00304"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29968" checksum="0B4AA9AB986E9A09" modified="2017-06-07" version="1">MRILKSVLVLAVAMSIFGCENKELVMCQEKNETLLSDVESLEAKVAAQKEQFAEAKQKWDEAQTKAMKAIQTMMQKQQAKSEEMQAKLNAAKTDAKQWRIKAQEAQQEAAKADQKLEETKVMVREVGKKMKEELGGLEEKLASAENAKTELAAEVNELESSNATLEKQVEELKSANEALKKEIEALKAQMEKANAAAESEQAASAKEINALEAKIKQLNAASQAEQVASTKKITELKTANEALKEQLNKLEGRIEKMNASAEDEKVEAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY0</accession>
    <name>A0A1U9NGY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67191">
        <property type="protein sequence ID" value="AQT67191"/>
        <property type="gene ID" value="STSP2_00334"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00334"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19770" checksum="B056AFE4D09501FB" modified="2017-06-07" version="1">MKFGKNVWVVIRAVILLAICGGVVYKLSSSPELAEVDMKMPTPEGWIEYMGATIFVALGIMIFGGFAILASWLYTKFSGKRPKRGDLSWRVYLSKHVMFFGPRHIHFSGTSPVFVFGFISECLGAVAVGFVVAGIIEGLGVLAAGGIFFGVMAASFFVGNRVALRLFGEDDDDGGSSEAVAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ6</accession>
    <name>A0A1U9NGZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67202">
        <property type="protein sequence ID" value="AQT67202"/>
        <property type="gene ID" value="STSP2_00345"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00345"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8307" checksum="9B15D635A4249939" modified="2017-06-07" version="1">MITPGIGGILVLLFIMFGLGLTVLWVWMLVEAATKEPSEGNDKIVWVLVIVLAGWIGALIYLLARRPERIRKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH33</accession>
    <name>A0A1U9NH33_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliD</name>
        <name evidence="8" type="ORF">STSP2_00048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00048"/>
    <dbReference type="EnsemblBacteria" id="AQT66910">
        <property type="protein sequence ID" value="AQT66910"/>
        <property type="gene ID" value="STSP2_00048"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00048"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
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        <location>
            <begin position="452"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="753"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="813" mass="87402" checksum="EC9FAEBA7ADBF2C2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH44</accession>
    <name>A0A1U9NH44_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_00266</name>
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    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5012120703" evidence="1">
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            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15427" checksum="551C18BC4E02B664" modified="2017-06-07" version="1" precursor="true">MSSKAMKWTALLALLAIIAVPAIAAEHNQGRSESTYERSAEFIPNYNTTAAGRWIRRSPAVERQQQQQDLLAGPRKFVGDTGRAIGSGLAGTWKAIQSPFVSKEDLDEETYQAEREDEAEFIPNYDTTAAGRWIRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH81</accession>
    <name>A0A1U9NH81_9BACT</name>
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        <submittedName>
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        <name evidence="8" type="primary">mucD_1</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.107" evidence="8"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="degP_htrA_DO"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="377"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="479" mass="51835" checksum="6A51E92AF07B7BDB" modified="2017-06-07" version="1" precursor="true">MKSLKRTVFLTTLITAFALPSQTFSAEENHGIATLRETSQAFTKVAQKAIPAVVSVQVEKEIQASSRGGMPRGFPFEDDFFERFFGPEFRQRQQQPRIQRGQGSGFIISKDGYILTNNHVVGEADKIKVILTDSREFEAELVGADPKSDVAVIKVESDEDLPVIELGTSEDLRIGEWVIAVGNPFGLTETVTVGVVSAKGRGIGITGAEGYEDFIQTDAAINPGNSGGPLLNIEGKAIGVNTAIFSQSGGYMGIGFAIPMDMAKVIKDQLIEKGKVTRGYIGIYLDNVDADLADYFDLEPGQGVQVTDVVEDTPAKKAGLKEGDIILEVNGEAVEGVQPFRNDVALLTPGTEVELLVMRDGEKREMELTVGSLEDAQMATAMSDIAEKLGLQVQEMTEELAERFDYTAGSGVIVSEVSPASPAARAGIEPGMAIMSVNRQEVNSVEQFNEALAQSENNRVLLLVRDGRFTQWVVLNYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF0</accession>
    <name>A0A1U9NHF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67188">
        <property type="protein sequence ID" value="AQT67188"/>
        <property type="gene ID" value="STSP2_00331"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00331"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="20476" checksum="39B1F307C4246404" modified="2017-06-07" version="1">MDEKLKKYQEIHEPDFRSTVWVRIDRNSEVEKHETLRNLYDDIALIELSSDVPDKIKSQFNIARNLGLYTWYCYSFHQICELKAFSSLEFALREKFAVKRPGLKKLLKRAVSEGVLTDSCFSHVEIKDKNSTSYCERLIDVIPALRNDLAHGSMTLHHHSIVTLRKCADMINGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI0</accession>
    <name>A0A1U9NHI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inner membrane lipoprotein YiaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yiaD_1</name>
        <name evidence="5" type="ORF">STSP2_00347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00347"/>
    <dbReference type="EnsemblBacteria" id="AQT67204">
        <property type="protein sequence ID" value="AQT67204"/>
        <property type="gene ID" value="STSP2_00347"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00347"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012707958" evidence="3">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="28377" checksum="32EF24D5AEE55691" modified="2017-06-07" version="1" precursor="true">MKSCRIVMLLVVAGLLVAGSGCVSQEEYQSLKDQNRIQQETITSLESQVRNAELQVDQMEKQLEALRARMGADTEAQAEEIAALEADIAAKKQLIEQLRAEMLRGGVKLPMGLSLKLRDFAESNDMVDFDEERGVLKFKSDFLFAPGSAQVQQQAMESINLLSDIMTSGDGEEFDVIVAGHTDSDPIKYSKAKHPTNWHLSAHRGIGVLQKMVGAGVDPERLSVRGFGEYRPVASNETKEGKAQNRRVEIYIVPQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ8</accession>
    <name>A0A1U9NHJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00124"/>
    <dbReference type="EnsemblBacteria" id="AQT66986">
        <property type="protein sequence ID" value="AQT66986"/>
        <property type="gene ID" value="STSP2_00124"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00124"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="71"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="272"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="484" mass="54930" checksum="907722019C37E089" modified="2017-06-07" version="1">MPTDLLAQTITAPPPPKKQNNLAFILLQTRNNLDFLRLVVILKLDISFYRGLLLKRAVEKQVLMWKDSSRRKPLIIRGARQVGKTWLVENFLARQFDSFVKIDLEKRRDIHNYFEGDLDPETILPYLELESGRIIPGKTLLFFDEIQACPRAIMALRYFYEQMPELHVVAAGSLLEFAFGEISIPVGRVQYLYMHPMTFYEYLLAMGKETMAEFMLKPPSEVAPEIQRKILSELKSYFFVGGMPECVKTYRDSNSMIEAFNVQSEILDSYRDDFSKYTPSIDITCLDSVFLNVAKSIGEQLKYTRLNAAHSGQMNHKAFDLLVKAKIIHKIPSCDPSGLPLGASANQKKFKAAILDIGLLQRLCQVPVELELKQKNLLAMYRGILAEQFVAQELLAKDGSELYYWARQARGSSAEVDYLAVRNGQIYPVEVKSGAGGSLKSLHLMLAKYSNCPEGIVLYSGTFNELPEQKIVFMPLYSATTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN3</accession>
    <name>A0A1U9NHN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">clpB1</name>
        <name evidence="10" type="synonym">clpB</name>
        <name evidence="12" type="ORF">STSP2_00589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00589"/>
    <dbReference type="EnsemblBacteria" id="AQT67442">
        <property type="protein sequence ID" value="AQT67442"/>
        <property type="gene ID" value="STSP2_00589"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00589"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="412"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="863" mass="96885" checksum="E9153DB8D247C5D8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV7</accession>
    <name>A0A1U9NHV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67511">
        <property type="protein sequence ID" value="AQT67511"/>
        <property type="gene ID" value="STSP2_00659"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00659"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="454" mass="51473" checksum="B3D9D5AC329E63A8" modified="2017-06-07" version="1">MDKILKANLKHLYQRRAMWFFWIIGGMFTVAIAGWIITEKEQGAFALPALWMFVAGVLLSVPPLEVMTKPFSYCLPGHRTIPRKFLFTVNFMLGFLWSLVFLAYPDLSFSTGLFTVLGAFSLFTIAFWAGVLDRIYLRNKTVLLLAVLFVWLPLQELGAAVLYFTVVFPWMLISAGIFINYLIWRHLQLADLPRRYCSARQVELGIQAESKKNNVNEALKEEQASSYLKGICNDVDNFFLRRIRESIGVRRYLLGNIYRIFGPIFLKSRFKAWACLLWLIVVIYLGYMGPASSILFFMPVIMAASLNLGVHSGLLVCNGRGERLWSALTGAVVFGLFVTFVLFLIAAFTKLLSPVMPTFNSNEEVYSFAPLDPRYCLMTLSLIPIGYIGQLIFPRRQMLQMMPAIAVLIFGASFFVPFAGDSFPLLGLTAVVMGGSWGVFVVVLRYVCRWRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY2</accession>
    <name>A0A1U9NHY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase isoenzymes formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypD</name>
        <name evidence="3" type="ORF">STSP2_00691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00691"/>
    <dbReference type="EnsemblBacteria" id="AQT67543">
        <property type="protein sequence ID" value="AQT67543"/>
        <property type="gene ID" value="STSP2_00691"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00691"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="39781" checksum="45F2C4E88E510931" modified="2017-06-07" version="1">MLRRILKAQNLMDCACRKLGRQLNIMEVCGTHTVSIFRNGIRPTLPKSLKLLSGPGCPVCVTDQGYIDVTVELAKRDDVILATYGDMIRVPGKSGSLEQLNRSNVKVVMSSDEALNLARENKDKTVVFVAVGFETTTPATAVAVGQAADENLENFTVLSGHKLVIPAMKALLTDKNNKIDAFLCPGHVSVIIGSDAYKTVLDDFDVPCVVAGFEPMQVIEGIGEICRQIYKDDIKVESIYHAAVKPEGNPTAQKIIDQYFEAFDGPWRGLGNIPGGTLRLKEEYAQFDAFKRFGIDQVPTEELNGCKCGEVLCGLIDPPQCPKFENTCTPDTPIGPCMVSSEGACSAWYKYGRRRRRRRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI12</accession>
    <name>A0A1U9NI12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00709"/>
    <dbReference type="EnsemblBacteria" id="AQT67561">
        <property type="protein sequence ID" value="AQT67561"/>
        <property type="gene ID" value="STSP2_00709"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00709"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="381" mass="43741" checksum="E354CA97661A2D16" modified="2017-06-07" version="1">MSSNEKQKGQKHKKSMLVRFGKMGYVGWFEHGETNISNQRDQVVIKTHRGLELGSIINPHCHKHGQFRCSKEEVNQYYEGASKDYPMTRGGTFVRYATQEDIMEARHLDSSAQKELKTCQEFAKEMGLPMKLVDAEHLLGGERIVLYFTSDTRIDFRELVKRLAREYQTRIELRQIGARDEARLISDYETCGQECCCRRFLKILAPVNMRMAKLQKATLDPSKISGHCGRLKCCLRYEHDTYKDLKKRLPKRGTIVKTEAGEGRVVDTSILTQLVVVQYPNSNREAVPVDEIEIVGKPGSRDKGQAKDGKQDEGRDQKQAGDKGKETEARDTRSEKQQQKPKSKRRRRRKRKDNRNTDRNESSQSNSSGDRPDNSQAKDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI18</accession>
    <name>A0A1U9NI18_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">STSP2_00730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00730"/>
    <dbReference type="EnsemblBacteria" id="AQT67582">
        <property type="protein sequence ID" value="AQT67582"/>
        <property type="gene ID" value="STSP2_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00730"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="40479" checksum="1F8FA1C73E2D9B47" modified="2017-06-07" version="1">MKRISILNGIVGYKKKVGLAPGTLVHVGEEEARTCELSLIQYDADDVHESSIEADTDFGALRKEDKVCWLNVDGLDDVDVIDRIGEAFGVHDLILEDVLNTGQRPKLEEAEEGLFITVKMLQANEGQISSEQVSMIVGDGYVISFQERAGDVFESVRERLRSGRGRVRKAGADYLAYCLLDAIVDNYFAVLEQLGERIEADQVQLMEEPDEEVLAEVHGLKREMIFLRRAVWPLREAINALSKSDSPVIRKETRIYVNDVYDHTMQIIETLETFRDVVAGMFDMYLSSVSNRMNSVMKVLTIIATIFIPLSFIAGVYGMNFNNMPELTTGWMYPLGFWLMVFAVAVGMLGFFKYKKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI34</accession>
    <name>A0A1U9NI34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">STSP2_00552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00552"/>
    <dbReference type="EnsemblBacteria" id="AQT67408">
        <property type="protein sequence ID" value="AQT67408"/>
        <property type="gene ID" value="STSP2_00552"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00552"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidylate_kin"/>
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        <property type="entry name" value="Cytidylate_kinase_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="219"/>
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    <feature type="binding site" evidence="8">
        <location>
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            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24593" checksum="E56D9414E06EC4BD" modified="2017-06-07" version="1">MDKLIVTIDGPAGSGKSTIAKLLAEKLDARFLDTGAMYRAVTFAAMRKNVDLHDEQAILSMIAATEFDFERTDGPMTVRIDGEDVNSDIRTSHVTSHVKYIANSPAVRSELVRMQREYAQKAQRIVTEGRDQGTVVFPDADYKFFLTADARERARRRLKDLEAAGETVDLDKLQQQIETRDAEDENRKVGALKCAYDAMKIDSTKLDIEGVVAAILDHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI41</accession>
    <name>A0A1U9NI41_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Acetate transporter ActP</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">actP</name>
        <name evidence="8" type="ORF">STSP2_00632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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            <dbReference type="RuleBase" id="RU362091"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67485.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="720" mass="76507" checksum="FE3E9894D0C24A4F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI46</accession>
    <name>A0A1U9NI46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane assembly lipoprotein YfiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67186">
        <property type="protein sequence ID" value="AQT67186"/>
        <property type="gene ID" value="STSP2_00329"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YfiO" evidence="1">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="360" mass="40760" checksum="2E0D15A43CCB14CC" modified="2017-06-07" version="1" precursor="true">MKIKDLRRFIIAVLTLAALTCALTETGRADTWRLNPKGEWDNLVDTPEGSQMMEVANAKKLIARGKTKEAKEALLQLRQEVTELQGPDLDAFIDAELQYADGNYDKAAQLYKAFLEDYPDSWLYESALRRTYQIATAYLYGRKRPVLKVFKLSAYEEGADLMHHIADLAGDAPIAKDALTEIAVAAEKRGEYLEAYQAWAEVSATWPTGELGQKALLGMARSLHSSYQGPGYDTTSLVSARTYYVNYKLRYPEAAEENNVQQQIELIDEQLAYKQYKIGEYYVRAEKTQAANLYFQAVIDTWPDTKSAVLAQKQLSPGDDPSVEVKKDWKRKTFEGVEDLLDEWYGLHKIFPELPAPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI71</accession>
    <name>A0A1U9NI71_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Ribose and galactose chemoreceptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trg</name>
        <name evidence="5" type="ORF">STSP2_00663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    <dbReference type="EnsemblBacteria" id="AQT67515">
        <property type="protein sequence ID" value="AQT67515"/>
        <property type="gene ID" value="STSP2_00663"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00663"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cache_3-Cache_2"/>
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        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
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        <property type="entry name" value="MCPsignal_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
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            <end position="628"/>
        </location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="699" mass="74339" checksum="068DB33E4C05C4E5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI97</accession>
    <name>A0A1U9NI97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein STSP2_00810</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00810"/>
    <dbReference type="EnsemblBacteria" id="AQT67662">
        <property type="protein sequence ID" value="AQT67662"/>
        <property type="gene ID" value="STSP2_00810"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00810"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27203" checksum="5C51751DBA01E17E" modified="2017-06-07" version="1">MAGHSHWAGIKHKKAANDAKRGKLWSKIARQLIVAAKAGGGDPSTNLTLRYSIDKAKDANMPKDTIEKAIKKGTGELGAIEYVEVLYEGYAPGGIAVMVDGLTDNRNRTAPEIKKIFERRGGSLGASGCVNWMFKKKGLITVKTDAIPEEDLMDIALTAGAEDMENTGEIYEITCDPAAYEDLRAALKENDIPTETAELSMIPENTVAVNDVETAKKILSLMEDFEDHDDVQNVYANFDIPDDILAQASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB6</accession>
    <name>A0A1U9NIB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67661">
        <property type="protein sequence ID" value="AQT67661"/>
        <property type="gene ID" value="STSP2_00809"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00809"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="52492" checksum="75CB427A3B167767" modified="2017-06-07" version="1">MDRRQFIKSSGLVAGAALQGSVFAAASRPDKKRPNFLMITCHDLGQHLGCYGIKEVESPNIDRLASRGVRFANMFSTSAVCSPARGALHTGRYPQTNGLMGLTHAPWWWKFKNGETHAAQMFRKAGYDTCLCGLQHIFGAGEAGRYGYDKVLGRKKGAEETVQVSSEFLVNRKADDSPFFLKVGFFEVHRRGGSFKHREYDPAKPVHVPGYLADTPVMREDLGRFQEEIRYFDSCVGRILDSLQKSQCAENTIVVFTSDHGIPYPGAKWTIRDAGIEVPLIMYMPGGALSGGKVCDAMISHVDVLPTLLDMAEIDKPANLEGVSFADYLAGRSDAKPREEIFAQFTPAMFRDNESRCVRTEKYKLVRFFSAGRCVKYPIDVDPVRYAMHKERAATNWKPRPFVQLFDVQNDPDELNDIGGEKGNAEIVRDMSRKLYAWMKAVDDPILKGPMESPYYRDSMEDFENAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB7</accession>
    <name>A0A1U9NIB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaE</name>
        <name evidence="10" type="ORF">STSP2_00713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00713"/>
    <dbReference type="EnsemblBacteria" id="AQT67565">
        <property type="protein sequence ID" value="AQT67565"/>
        <property type="gene ID" value="STSP2_00713"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00713"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1157" mass="129222" checksum="A66C07D8A1D5AE36" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF3</accession>
    <name>A0A1U9NIF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67567">
        <property type="protein sequence ID" value="AQT67567"/>
        <property type="gene ID" value="STSP2_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00715"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364396" evidence="2">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21826" checksum="2E62A53B3E8D5A04" modified="2017-06-07" version="1" precursor="true">MIKKSITAALLSVAIILGSGIALAADDGKQDSKEEKAKVKAEEGQKQEVQRPDRPARRQRRSPRDARKMFYEQRLKQLEKELKERTTEHENFIKELEAIKELAKEEDATKTADQVDRLIGKMNRKFEGEIEVYKNRLEQFKKSMEQRLEGRRERPERGRNRQENEQSDGENKQKGRRMGSMKAPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL3</accession>
    <name>A0A1U9NIL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67430">
        <property type="protein sequence ID" value="AQT67430"/>
        <property type="gene ID" value="STSP2_00577"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00577"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301692" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9359" checksum="FA03D3778FF35A72" modified="2017-06-07" version="1" precursor="true">MSRFSIMTLSTVIIAIILSASPAHAAMQEEFIMWYDKPADDYGFKSPLRCWEVENPNRTHKPNPDQAWEKYALPLGNGLYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU4</accession>
    <name>A0A1U9NIU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ispD</name>
        <name evidence="4" type="ORF">STSP2_00792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00792"/>
    <dbReference type="EnsemblBacteria" id="AQT67644">
        <property type="protein sequence ID" value="AQT67644"/>
        <property type="gene ID" value="STSP2_00792"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00792"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26750" checksum="816FEB7383FDF7D4" modified="2017-06-07" version="1">MKNVAVIICAAGAGKRFGGKTKKPFVKIGGRAVFLRSVDFFVNHEAVKQIILAISPEDEESIKINFGATLGFCGVQVVHGGAERFETVENALKEVREDIDLVAVHDSVRCCLKDEWVSGVFKKAGETGAAMLACPVVATIKRVEGDKIVETVDRRGLYEAQTPQVFEAGLLRRAYEKLHEMDKAAISDDAQLVEALGEAVHVVETDSTNVKITKQADMEIAESVIKARDKAKVKKTGSPFFEAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ16</accession>
    <name>A0A1U9NJ16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67777">
        <property type="protein sequence ID" value="AQT67777"/>
        <property type="gene ID" value="STSP2_00926"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00926"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="19300" checksum="3B064061713ACD10" modified="2017-06-07" version="1" precursor="true">MKSLKRTALVTTTICMLLSGCGKSPEQASAETQQIEELRSQVQNLQQQLQQTQQQKQQLEQQLRTATGMLEKITAQLQAAAQENETVQQQMQQMEQTNGQLQQEIQTLKNNRQQETTDFQQSERSLEELKRKLEQYDRKIEEYEERIERLESELERTQTQQSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ28</accession>
    <name>A0A1U9NJ28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67516">
        <property type="protein sequence ID" value="AQT67516"/>
        <property type="gene ID" value="STSP2_00664"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00664"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="764" mass="86633" checksum="319269674CBFBC88" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ47</accession>
    <name>A0A1U9NJ47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01114"/>
    <dbReference type="EnsemblBacteria" id="AQT67962">
        <property type="protein sequence ID" value="AQT67962"/>
        <property type="gene ID" value="STSP2_01114"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01114"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="198"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="405" mass="45408" checksum="AC476F9CC86DD58C" modified="2017-06-07" version="1">MYIERTITGALQRASKHFPVILITGPRQIGKTTCLRHSADQNRSYVTLDDPQARELAIDDPKLFLQRFTAPVLIDEIQYAPQLLPLIKMAVDSGANKGDYWLTGSQQFHLMAGVSESLAGRVGILQMLGFSYTELINQGQTSKPFMPDTRDFYSTKKPIGLKELYEHIWRGSFPAIVTDEQMDRDLFYSSYVQTYLQRDVKSLVNVGDEMAFMKFLRGAAARTGQLLNVAELGRDAGITHNTAKRWLSVLEASGLVFLLQPYHGNFTKRLVKTPKLYFMDTGLAAYLTQWTTPETLEAGAASGAFFETWAMTEIIKSYWHNGKAAPVYFYRDNDQREIDLLIVQNGKLFPAEFKKSAAPGKDDVRHFAALERFNMPVGHGAVVCLTDTVIPLSKNTTAINVSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ55</accession>
    <name>A0A1U9NJ55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67959">
        <property type="protein sequence ID" value="AQT67959"/>
        <property type="gene ID" value="STSP2_01111"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01111"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="23189" checksum="4871C5581CB702A7" modified="2017-06-07" version="1">MSKRIIYYTDNSIDDTRLAKVARKYIRRSSIAVTSVTHKPMEFGDNFVFYNPPSARSILRQVLMGLYTTPEKTVYLCEHDCLYHRSHFALETDGVAFNTNVYRLTNRGFYKKSEWVLSQLIADRDCLIQAIEQKLAQPDPIKLLEPGRGDNWPVELLQSKLPNVDVRHGRNFSHWRPRGKRRCRIPHWGHYAGQVANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ87</accession>
    <name>A0A1U9NJ87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67981">
        <property type="protein sequence ID" value="AQT67981"/>
        <property type="gene ID" value="STSP2_01135"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01135"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="28289" checksum="482BB38053D67295" modified="2017-06-07" version="1">MKRFKWQIFLGVGLVGMSAVLYFVHYLMFHDAHHIFIYLMGDIAFVPIEVLMVTLILHELLASRDRRNKMNKLNMVIGTFFSEVGTELLRFLASHDSNSDMLGEVLDVEGNWTKAEFGSARNDLQGHDFKLSVERNELSEIAEMLVGKRGFMVTLLENPLLLEHDRFTDTLWAVFHLTEELASRRDFSTLSDKDLAHLTGDMERAYSQAAVEWIHYMEHLKSEYPYLFSLAMRRNPFGSSEDAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD3</accession>
    <name>A0A1U9NJD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68043">
        <property type="protein sequence ID" value="AQT68043"/>
        <property type="gene ID" value="STSP2_01197"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01197"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="72" mass="8148" checksum="9BABB7F9BB438B15" modified="2017-06-07" version="1">MKKYNYKTIIAAILILLTVIIIFQNIESVNTKFLFVSIKMPRALLLLITFALGTLTGLLLANKIARKPKDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG5</accession>
    <name>A0A1U9NJG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative neuraminidase (Sialidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68061">
        <property type="protein sequence ID" value="AQT68061"/>
        <property type="gene ID" value="STSP2_01216"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01216"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="680" mass="75877" checksum="F5EA7A358B795BA7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH8</accession>
    <name>A0A1U9NJH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atsA_10</name>
        <name evidence="3" type="ORF">STSP2_01234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68079">
        <property type="protein sequence ID" value="AQT68079"/>
        <property type="gene ID" value="STSP2_01234"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01234"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="52529" checksum="22B17FBA88419840" modified="2017-06-07" version="1">MNRREFLKTAAFTAGSVAAGAAAGKAGEVALSNKVMNMRTGRKRPNVIYILADDLGYADLGSFGQEKINTPTLDRMAAEGMRMTQHYSGSTVCAPARCSLMTGQHTGHCYIRGNATVALRPQDFTVAEMFKQHGYATSCIGKWGLGDLGTTGHPNEKGFDHFFGYLSQLRAHHYYTDYLWRNTEKVPLNGKTYSHDLMTQEALNFVDDNKDNPFFMYLAFTIPHAELLVPEDSLEEYRELGWPETPWPGGHYGAQETPRAAYAAMVTRMDRDIKRLFDRLKEHGIDEDTLVIFTSDNGPHAEGGNDWAFFDSNGPFRGIKRDLYEGGIREPMVVRWPGKIKPGSKSDHISAFWDFMPTCADLLGVEPPSSTDGKSFLPALLGKTQEQHEYLYWEFHEGGGKQAVRKGKWKGIRFNLKNEPNPPVNLYNLDTDPGETTNVASVYPGIAAELKQLMLEAHERSPIFKFYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI5</accession>
    <name>A0A1U9NJI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01236"/>
    <dbReference type="EnsemblBacteria" id="AQT68081">
        <property type="protein sequence ID" value="AQT68081"/>
        <property type="gene ID" value="STSP2_01236"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01236"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="29531" checksum="54D24D357966D834" modified="2017-06-07" version="1">MNRKAFTLIELLVVISIIALLLAIMMPALSMVKEKARGVVGMSRVKQWGLCYQLFSNDHDGSFPEFKTETTNTTFMYDLKDYYSDIDEMRFCPSAKKISQSNPTGMQQGSFFGSTLEAWKVNVQEAIWMEDDDIGAGSYGENSYIRKLEGSSKTWGRANMPRANTVPVLMDARWNNAWPDNNQPLRRSATTDQEFYDAGNWSSISCFVMRRHGDGINMTMADGSAQKVDAEELWQLRWNRQFEREGEKDLSFMKWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ8</accession>
    <name>A0A1U9NJJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68099">
        <property type="protein sequence ID" value="AQT68099"/>
        <property type="gene ID" value="STSP2_01254"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01254"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012278995" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="788" mass="85218" checksum="F98698B2E81F169B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK0</accession>
    <name>A0A1U9NJK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">exo I_3</name>
        <name evidence="7" type="ORF">STSP2_01149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67995">
        <property type="protein sequence ID" value="AQT67995"/>
        <property type="gene ID" value="STSP2_01149"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01149"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="158"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="630" mass="70713" checksum="9C856AAEF924AAC8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL9</accession>
    <name>A0A1U9NJL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68119">
        <property type="protein sequence ID" value="AQT68119"/>
        <property type="gene ID" value="STSP2_01274"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01274"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5509" checksum="20E8ECC8B34848AC" modified="2017-06-07" version="1">MRMHGHLVNKTLGLEGRFWAIFGVEKLGKSRMKVRRNGVKVSKDGVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN2</accession>
    <name>A0A1U9NJN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68129">
        <property type="protein sequence ID" value="AQT68129"/>
        <property type="gene ID" value="STSP2_01284"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01284"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="377" mass="41615" checksum="56F418D482B25618" modified="2017-06-07" version="1">MVSVDGEPVEAGSIVFFRQDVGRVRLVWPPMAPGGEIDGKGRYEIEAIEPGRYVMAVHPDYGARTASAMGENEAGAEEELLEVNMVRVVEIGEGQEVLDVEAGERVLAGRIVDWNGEPVAEGAVYVSPAEAREGWHPLYMSVHSQTDEQGRFAVEHMVDGVYDISVHDAQMGVHLKKGVVVDSEMEELVWELDEVVKVDMDAAELESWERDTIMPYAMVVSRDEPKLMSLRDHGLGVEGFGRAMFRAGEYDVFFMAKRQGYACDGRRVVFEEGMELESPFVESGTVKVVLDGEADEVAGRTVRIRHAGGDELVRLYDPMWSYVPDLCPAVVLPTCSEGVTYISWLEPGEYEVFVEGAGESERIEVEAGEVAEVEMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU2</accession>
    <name>A0A1U9NJU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW_2</name>
        <name evidence="2" type="ORF">STSP2_01347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01347"/>
    <dbReference type="EnsemblBacteria" id="AQT68192">
        <property type="protein sequence ID" value="AQT68192"/>
        <property type="gene ID" value="STSP2_01347"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01347"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18270" checksum="DB1DAC1F428D79A6" modified="2017-06-07" version="1">MAETKATAAKRDKMSSDAEKFLTFALGDEEFGIGIMSVREIIGCMDVTPLPQTPHYVKGITNLRGQVIPVIDIRAKFGMQETEVTDQTCIIVIETTIDGRPFSAGIIVDRVCEVLDIEQNQIDDTPQFGSDVDTDFIMGVGKVNEAVKILLDIDKVIGTSDMSGIPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU7</accession>
    <name>A0A1U9NJU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdtK</name>
        <name evidence="3" type="ORF">STSP2_01172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01172"/>
    <dbReference type="EnsemblBacteria" id="AQT68018">
        <property type="protein sequence ID" value="AQT68018"/>
        <property type="gene ID" value="STSP2_01172"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01172"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="503" mass="55409" checksum="8204D31268363E45" modified="2017-06-07" version="1">MLHKLKNHWSRPAGFREVLVIAIPLILSTGAHGLKTFTDRTFLTWYDSNAISASMLAGMVAFTVMSLFQGVVGYVNTFVAQYTGAKRHDRVGHAVGQGVYLALLAGMVMLLLIPFADYFFALVGHSPQIQQYESAYFKIICISATPALVSIAISCFFTGRGRTRLVMYITLTGTALNIILDYIMIFGKFGCPRLGIVGAAWATVLSATLQMTLFLYFYLAPVYRHKYSTLKGIKPDRLLFARMIRFGLPNGLHFFLSMICWTLFFGLSGKVSETAMSATAVAMQINSLSFMPMFGFAMAVSTLVGQRLGSDQPHLAQRSTWSAFAMTGTYMTTLAVGYIAVPDLFIFPFSSNADPEQFNRIIPIIRTILLFVSVHAICNTANMMFSSALKGAGDTRFVMISSVSLGYLLMAIPAWIAVRAGAGIYTLWALSTLYMLTIACVYFTRFILGKWKTMRVIESAPNAPPANAPSLPVDDIELPYPTDDTTDNPHEESHPQPVSKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK19</accession>
    <name>A0A1U9NK19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rex_1</name>
        <name evidence="6" type="synonym">rex</name>
        <name evidence="8" type="ORF">STSP2_01430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01430"/>
    <dbReference type="EnsemblBacteria" id="AQT68272">
        <property type="protein sequence ID" value="AQT68272"/>
        <property type="gene ID" value="STSP2_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01430"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22856" checksum="3ACA011144631F74" modified="2017-06-07" version="1">MPVNRKCIIRLSRYKNALQRLKALGFVKVFSDNLADAAGATPSQVRKDFSLFGITGNRRGGYVVDELIEQLREILGKNETQKVVLAGVGNIGRALMRYEGFGGGGISILAAFDIDPAKFDENADIPILPLERMHDFISENDVKIGILSVPDVAAQQVSELMQAAGIKGILNFAPIQLRGDDGAIINSINLEVELENLIYFVNAAKKGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK59</accession>
    <name>A0A1U9NK59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atsA_11</name>
        <name evidence="4" type="ORF">STSP2_01352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68197">
        <property type="protein sequence ID" value="AQT68197"/>
        <property type="gene ID" value="STSP2_01352"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01352"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="57267" checksum="B160CF36E7E08B44" modified="2017-06-07" version="1" precursor="true">MDRRSFIKLSGVSAAAFCMQGCAATSMSKLSKARGSKPNIVYIMADDLGYSELGCYGQEKIKTPNIDRIAKQGVKFTQHYSGSPVCAPTRSTLLEGKHTGHSFVRSNYELGGWERGNREGQLPLPADTVTLPKLLKKAGYTTGAMGKWGLGGPDTSGEPHKQGFDYFYGYLCQRQAHNYYPTHLWKDSAAGLEKVELDNEYFSAHQRFPKDKNPNDPENYEQYSGNDYAPDLMTEEALKFVKRNKDNPFFLYLPYTIPHVALQVPEDSLEQYEGMEDDPYLGDQAYLPNRTPHATYAAMITRMDDYVGKVMDLLEKLGLEENTLIMFSSDNGTTFNGGCDADFFDSVEPLRGLKCSVYEGGIRVPLVAKWPGRIPAGTTTDHISAIWDVLPTCTAAAGAPTPDDISGISMLPTMLSKDEKQKKHEYLYWEYNRQIAVRMGKWKAVRRRTDKTVDTPIKLYNLEKDIDESDNVADKHPEVVAKIKKIMKEAHTPSEYFPFPGEPRKKWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK71</accession>
    <name>A0A1U9NK71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67980">
        <property type="protein sequence ID" value="AQT67980"/>
        <property type="gene ID" value="STSP2_01134"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01134"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9776" checksum="46FFC0F5159D4016" modified="2017-06-07" version="1">MQMSKVSKCDVTGCAYNTDNQCHAYAITIGNSGTPKCDTLCMASGKTDDTNSTAGVGACKTTSCKANKGFECTAPEITVGFQGNEADCLSFTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK82</accession>
    <name>A0A1U9NK82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">selA</name>
        <name evidence="7" type="ORF">STSP2_01373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01373"/>
    <dbReference type="EnsemblBacteria" id="AQT68217">
        <property type="protein sequence ID" value="AQT68217"/>
        <property type="gene ID" value="STSP2_01373"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01373"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="51078" checksum="BDEF6A650916BBFF" modified="2017-06-07" version="1">MSNTDKQTLLRNIPSVSAVLEQLKHQIDTQPTLLHSDITRACLDDLRSRILAGNGFEPPADLPQYVLDQVTDRITQLNGIYHARVVNAAGIVLHTGLGRAVVPKPALDHLTSDLAGYSLLQLSTDTGKRSRRDARIEQLLQTLTGAPAATVVNNNAAATSIVLNTIAKDKEVIVSRGQLVEIGGSFRLPDVMAFSGAKLVEVGTTNKTHPRDYLSAITENTAAILRVHPSNYKVQGFSSEVPLDELVDIAHCNDLLMFDDVGAGSLLDFTRYGFDHEPTLVESVNAGADVITSSGDKLIGASQAGIILGKPDIITAIRKNQFARILRVDKMTLTVLEQTLKLFLDQENALKTVPTLRMMLRKPDSIRRQANRIKRKLAAACPNAQLAITKGHSQPGSGSLPAQSMPTSLVTVTAPNYSADQLARKLRKYKTPVFVRIQNEQVLIDPRTLLDGDEKTLIQALTWALSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR0</accession>
    <name>A0A1U9NKR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68387">
        <property type="protein sequence ID" value="AQT68387"/>
        <property type="gene ID" value="STSP2_01547"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01547"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9099" checksum="74DE83BAC76EBC21" modified="2017-06-07" version="1">MFSSLAIILGSFTSPMSIKMDPASLLWMFPLLAAIAIVYKATKMRVLFPAKFIKEVVVLFLTLSVFIVLAGAGLHVIVHFITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR3</accession>
    <name>A0A1U9NKR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general secretion pathway protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspG</name>
        <name evidence="2" type="ORF">STSP2_01688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68523">
        <property type="protein sequence ID" value="AQT68523"/>
        <property type="gene ID" value="STSP2_01688"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01688"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21832" checksum="11290D50C29FAA57" modified="2017-06-07" version="1">MALLESENMRACDRKSGFTLVEALTVIAVIGVLVSLVLGLGKSLKEQADERLANSTIEVLVTAIEQYLEFTSEFPFEADVSFNNASLESVLESQLGLPDGTVTVDAANPPEYASSEALFYVLDNCARSKGFVDSLSGGVTTNKDAAGSALVAEYGDIRIDLVRIVDPWGNALQYTYSAGDVFPELRFAGPDKELFTQDDVTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS7</accession>
    <name>A0A1U9NKS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68116">
        <property type="protein sequence ID" value="AQT68116"/>
        <property type="gene ID" value="STSP2_01271"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01271"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35154" checksum="DCCED22101BA1DB4" modified="2017-06-07" version="1">MEITAGIVLTSFLTIIIAAAALGFVGVPVMIRIRAALAAIVGVVVLGFFAWPMLKPSFPQGAVTLYHGDVSIVSIIACIILAALAGLLAYFAAWPNGRQLAPLAAPAGLAYVAFRSGQMFDLIIVNNGLTQRMDLYSGLKWEGIFWLAIVAAGYLGVFAAMKIKNEKVALTEDESAHKPGFNKGLAIAIALVAAVVIAQFASGIFAQDVRMRDPRLGTVIGQVATSQAALAMIIAFGLAALAVKYFLDISYVITTLATCLLVYWAMTAYGKGDILEYMTQNWPSAFYPRALGSILPLHIVAFGSIGCIAGYWSAVWFAHAKHEHEEHTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX3</accession>
    <name>A0A1U9NKX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fldA</name>
        <name evidence="2" type="ORF">STSP2_01727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01727"/>
    <dbReference type="EnsemblBacteria" id="AQT68559">
        <property type="protein sequence ID" value="AQT68559"/>
        <property type="gene ID" value="STSP2_01727"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01727"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16773" checksum="9A9F996953E04074" modified="2017-06-07" version="1">MATGLVIYHSRSGNTKQMAEIISEAMNEASLPTKCKSIEDVKLDELVKADAIVVGSPTYYGRMAGAVANLFDESVSKHGKLDGKVGAAFSSSANIGGGNETTVLNIVNTLLVHGMVIQGDPQGDHYGPVSIGKPDDRVINQCKRRGKRIAELTIKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL12</accession>
    <name>A0A1U9NL12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">malP</name>
        <name evidence="12" type="ORF">STSP2_01800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01800"/>
    <dbReference type="EnsemblBacteria" id="AQT68632">
        <property type="protein sequence ID" value="AQT68632"/>
        <property type="gene ID" value="STSP2_01800"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01800"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="867" mass="98829" checksum="ACF90A529019B93A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL80</accession>
    <name>A0A1U9NL80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="11">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="11">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">pheT</name>
        <name evidence="14" type="ORF">STSP2_01861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="366"/>
        </location>
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        <ligand>
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        </source>
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        </source>
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        </source>
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    <sequence length="672" mass="74233" checksum="6617C4EF3589932A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC6</accession>
    <name>A0A1U9NLC6_9BACT</name>
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        </alternativeName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="13" type="primary">dmdA_2</name>
        <name evidence="13" type="ORF">STSP2_01530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate = D-threo-isocitrate</text>
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            <dbReference type="ChEBI" id="CHEBI:15562"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT68370">
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        <property type="gene ID" value="STSP2_01530"/>
    </dbReference>
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        <property type="reaction ID" value="UER00718"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:citrate dehydratase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
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        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
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        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
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        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACONITASE"/>
    </dbReference>
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        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="650" mass="69533" checksum="D1598877AA8D61B3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE4</accession>
    <name>A0A1U9NLE4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68751">
        <property type="protein sequence ID" value="AQT68751"/>
        <property type="gene ID" value="STSP2_01923"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01923"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="16404" checksum="5A8D2A285D271856" modified="2017-06-07" version="1">MQKNESTNNEQNLNGVIIINRTQIKDYLGGMVRQNVEETLNAMLDAEADQLCNARRYEHTDKRTDARSGHYKRKLQTRTGQVELKMPKLRKTTFETAIIERWQIELFFKTIKQNFKIKTFVGDLPPWGHPQRTLTRAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ7</accession>
    <name>A0A1U9NLJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialidase</fullName>
            <ecNumber evidence="4">3.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nedA_5</name>
        <name evidence="4" type="ORF">STSP2_01847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01847"/>
    <dbReference type="EnsemblBacteria" id="AQT68677">
        <property type="protein sequence ID" value="AQT68677"/>
        <property type="gene ID" value="STSP2_01847"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01847"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052794">
        <property type="term" value="F:exo-alpha-(2-&gt;3)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:exo-alpha-(2-&gt;6)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
        <property type="term" value="F:exo-alpha-(2-&gt;8)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029456">
        <property type="entry name" value="Sialidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14873">
        <property type="entry name" value="BNR_assoc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956677" evidence="1">
        <location>
            <begin position="28"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="BNR_assoc_N" evidence="3">
        <location>
            <begin position="185"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="367"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="678" mass="74625" checksum="7A4C5DD1E2879BEA" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP7</accession>
    <name>A0A1U9NLP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rarA</name>
        <name evidence="4" type="ORF">STSP2_01576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01576"/>
    <dbReference type="EnsemblBacteria" id="AQT68416">
        <property type="protein sequence ID" value="AQT68416"/>
        <property type="gene ID" value="STSP2_01576"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01576"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="57"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="446" mass="49082" checksum="EF7F1911D30B249F" modified="2017-06-07" version="1">MAKDSKNSLFESAEREKIQQNAPLAVRMRPRDLDEFAGQQHFIGPGKLLRRMLDAGRLTSVIFYGPPGVGKTSLARLIATLTEAKFHYISAPAASVKDIREIIDTAKSRLMSSGPRTLLFIDEIHRFNRAQQDVLLDDVENGVVTLIGATTENPFFSVNSPLISRSTIFNFEPLDQSDIITLLRRAICDPERGFGKLDIDADDDALEYLALMCDGDARRALTALEVAILSQQKTGGRGQKIRLDLTIAQESIQKKSIRYDSDTHYDLASALQKSMRGSDPDATTYWLARMIAGGEDPRFIARRIAVCASEDVGNADPMAVVVAASAVQIAELVGMPEAQLALSQAAIYVACAPKSNASASAIWQAVSDVKAGRTIPVPAHLKDAHYKGAKKMGYGTGYKYPHKSPTGFVPQDYLGEELGKHYYEPKEVGREKTVKQHLQKLRKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM60</accession>
    <name>A0A1U9NM60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68897">
        <property type="protein sequence ID" value="AQT68897"/>
        <property type="gene ID" value="STSP2_02074"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02074"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="14389" checksum="98890C1824BEA948" modified="2017-06-07" version="1" precursor="true">MNPSNKNRNGFTLMESMMATVVLAMVAAGVALPLSSGANVQMEGARLTMAAKLANDLMAEVAATDFDSISSTFDGLSESSGALTEYDGDLLSGPAYEGFSRSVNCSTATVGKVDMLWVTVSVSHDGEELVALKRLFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM65</accession>
    <name>A0A1U9NM65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfA_3</name>
        <name evidence="4" type="ORF">STSP2_02177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02177"/>
    <dbReference type="EnsemblBacteria" id="AQT68999">
        <property type="protein sequence ID" value="AQT68999"/>
        <property type="gene ID" value="STSP2_02177"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02177"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35432" checksum="F43986FBC7692251" modified="2017-06-07" version="1">MKASGIWILAEQKGGKIADVSFELLTRGIKLSEERGCELAAVILGKDLSDADLQELIDRGADRVICIEAEQLDHFLVEPYSNCLLELLGEERPEVLIAAATSTGRTLMPYLAIQANAGLTADCTELSIEKDTGNLLQTRPAIGGNIMATIKTPEHRPQMATVRPRSAPPATRHKGRSGPIERFKPSEGSLGSRVKRLSFLPDADEKPLGDAGVVVAVGKGIKKAENIAIVKELADALGGALGATREVVDRGWLSYPHQIGLSGQTISPKLYVGVGVSGTIQHLAGMQTSEVIVAINNDPEAQIFKIADFGVVGNLFDVVPAMVEKLKAGRGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB8</accession>
    <name>A0A1U9NMB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68975">
        <property type="protein sequence ID" value="AQT68975"/>
        <property type="gene ID" value="STSP2_02153"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02153"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="43415" checksum="CD5BB635E78C275E" modified="2017-06-07" version="1">MQTDKAFVEVDFGQHSKSGQQAAGDVFLSKKIPEEGRTICVLADGLGSGIKAHVLATLTATMAMKYISSDIDIRRASEIIMATLPICSERKIGYSTFTIVDIRSDGRVSVIEYDNPPFRLLRDGVLVDIDKKKLEVATANRGRCEVLYSSFTARQGDRTVFYTDGVTQSGMGRDATPFGWGNDAVGSYIVEQCGMERDISARQLSRSVVEKARRIDGGKAKDDISCAVVNFRRPRKSVVMTGPPLDERKDTEMARILREYGGRKIVCGGTTARIIARELGEEISVDLGCLDSSVPPASNIAGVDLVTEGTLTLSRMAEILEAGEDPDKLKSNAAVRLARYLLDSDIIEFVVGTKINEAHQDPNFPVELDIRRNLMKRIVGLLNTKYLKQANMRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME2</accession>
    <name>A0A1U9NME2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein SoxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soxS</name>
        <name evidence="2" type="ORF">STSP2_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69079">
        <property type="protein sequence ID" value="AQT69079"/>
        <property type="gene ID" value="STSP2_02265"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02265"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="32776" checksum="B8F6F955DA468639" modified="2017-06-07" version="1">MIEWSVDIRTTRYLPSFEVPIHVEVEVQEDESYCHEGRFYKEQKHVIILFTYSGQGLFIDRDGKYELNPGSCLLCYPGATDICYKYPPGHKEPWRFLWFGFAGGSTRDKTSDLLDRFGPVYELTFNSKMIERLELLRAYNDVIYEMSPFEGSRLVLDVLCELGESTSANSVSQSNLLMQRTLKLIDAQLNEKISVNGIARTLKVSREHLSRVFKESTGTTLQKYIIDRKLKIACKLLNETNLSIKQITVRLGFNDQRNFSRTFHKKTGMTPRDFRNANLEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK4</accession>
    <name>A0A1U9NMK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5703_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69182">
        <property type="protein sequence ID" value="AQT69182"/>
        <property type="gene ID" value="STSP2_02369"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02369"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043757">
        <property type="entry name" value="DUF5703_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18961">
        <property type="entry name" value="DUF5703_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527453" description="DUF5703_N domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5703_N" evidence="2">
        <location>
            <begin position="234"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="979" mass="111316" checksum="0E34D42C60F778A0" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML4</accession>
    <name>A0A1U9NML4_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">STSP2_01918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1936003.STSP2_01918"/>
    <dbReference type="EnsemblBacteria" id="AQT68746">
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        <property type="gene ID" value="STSP2_01918"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01918"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="PTHR12872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504944" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="797"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111996" checksum="BE7DC1657B3E2FA6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML9</accession>
    <name>A0A1U9NML9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">barA_2</name>
        <name evidence="10" type="ORF">STSP2_02162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02162"/>
    <dbReference type="EnsemblBacteria" id="AQT68984">
        <property type="protein sequence ID" value="AQT68984"/>
        <property type="gene ID" value="STSP2_02162"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02162"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="313"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="545" mass="59689" checksum="8633522A31AB48CA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW9</accession>
    <name>A0A1U9NMW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-threonine 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02438"/>
    <dbReference type="EnsemblBacteria" id="AQT69249">
        <property type="protein sequence ID" value="AQT69249"/>
        <property type="gene ID" value="STSP2_02438"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02438"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="556" mass="59816" checksum="C4AD9F3E6BF9AF36" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ8</accession>
    <name>A0A1U9NMZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.312</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ligC_3</name>
        <name evidence="8" type="ORF">STSP2_02468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.312" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69279">
        <property type="protein sequence ID" value="AQT69279"/>
        <property type="gene ID" value="STSP2_02468"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02468"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050606">
        <property type="term" value="F:4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="50"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="214"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="438" mass="49065" checksum="AC206B1CD3745355" modified="2017-06-07" version="1" precursor="true">MSKGSGLNRRAFLKRAGAAGAAAIAFPHFVPATAMGKAWAAAPSERIVVGGIGVGSMGTGDLRNFLSRSNVQVVAVCDVDDRFANRAKGLVDKKYGNKGCATTRDYREILERDDLDAVFHALPDHWHSIISVACARKGLHIHGQKPLARTIWEGRQICDAVKEHNVVWQTGSWQRSQQHFRRACELVINGKIGDVKYVEVGLPDGKATGTKSLLDVPDALDWDMWLGPAPKRPYQDFGRGSCHWDWRWIMDYSGGQLTDWAGHHVDIAHWGLGLDRTGPVEIEGRGVYPKDGLYDVPIAYKFRCKYKNGVEMVVANRSQQPRGQGVVWYGEKGWIHVNRGGLWAEKPEVLRESILPNEIQLYDSNDHVGNFLDCVRSGKETITPVEVAHRSISVGLLGEIAMLTRRKLRWNPDTERFVDDEQANRYLSRPFRSPWHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN19</accession>
    <name>A0A1U9NN19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69197">
        <property type="protein sequence ID" value="AQT69197"/>
        <property type="gene ID" value="STSP2_02384"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02384"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16337" checksum="3507A297F59A6908" modified="2017-06-07" version="1">METKEQFKKRLKSEGRWDEFIKLREGLKRDGLSPKEAWAKARREFEPDFESVPVADNCGGCDSGDGAGMDSGDGIRRETFAAKPNVTARAVVQWVFDHIDVADVRPEDAPSSGAWSFLPRVRTYPKLLKEFYRSIWAKRQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN33</accession>
    <name>A0A1U9NN33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Demethylspheroidene O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.210</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtF</name>
        <name evidence="5" type="ORF">STSP2_02541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.210" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02541"/>
    <dbReference type="EnsemblBacteria" id="AQT69352">
        <property type="protein sequence ID" value="AQT69352"/>
        <property type="gene ID" value="STSP2_02541"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02541"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043803">
        <property type="term" value="F:hydroxyneurosporene-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="130"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35040" checksum="575CB9C366AB1CE6" modified="2017-06-07" version="1">MDKGFTYIHELIWGYRTARTLELAVKADIFTAMADGPANLDHICRKCGTKPDMTRKLLTGCQALDLVTESDGEFANTDLAAKYLLPASPYYQGNIIAHAFSVQEYWNSLENELFQQPPAPPTEQARHYHFIMGMDNIARGGRADLFLNSVDLTGRENMLDVGGGPGSYSIAACKKYTKLKSTVFDLPQTTEIAEKVITRENMTDRITTQPGDWNEDEFGSGYDVVLFSNVLHGPNSGAEMKLAKAHRAMQPGALLAIQEFVMNDEDAKPVPAAMFNIMVGAYKLYELMEVIADAGFTGVQVAGSNDEIGCMWITAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN87</accession>
    <name>A0A1U9NN87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nagA_3</name>
        <name evidence="7" type="ORF">STSP2_02266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.49" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69080">
        <property type="protein sequence ID" value="AQT69080"/>
        <property type="gene ID" value="STSP2_02266"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02266"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008456">
        <property type="term" value="F:alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="38"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="590" mass="65865" checksum="7769ECC285CFAC0C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC0</accession>
    <name>A0A1U9NNC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">atpA</name>
        <name evidence="13" type="ORF">STSP2_02578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02578"/>
    <dbReference type="EnsemblBacteria" id="AQT69389">
        <property type="protein sequence ID" value="AQT69389"/>
        <property type="gene ID" value="STSP2_02578"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02578"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="149"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="372"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="507" mass="55667" checksum="1E5E8F195DD15973" modified="2017-06-07" version="1">MKFDVNEISSLIKQEITRYRKEVDVATVGKVLEVGDGIARVYGLDNAMAGEMLEFENGVVGEAFNLEDESVGAVIYGEYEKIQEDSQVRATGKVLTVPVGHEICGRVVNALCEPIDGKGDIETQSKRLVEIAAPGIADRQPVRNPLITGLKSIDSMIPIGRGQRELIIGDRKTGKTAIGLDTIINQKGQDVICVYVAIGQKESTVAEVVRTLRDHGAMEHTVVVSASASESAALQYIAPYAGTAVAEYFMYEHGMDTLCIYDDLSKHANAYRELSLLLRRPPGREAYPGDIFYLHSRLLERSAKLHNDKGGGSLTALPIIETLEGQVSAYIPTNIISITDGQVYLQRDLFLGGIRPAVDVGISVSRVGGDAQPPAMKKVAPKLRLDLAQFRELQDFARLGTELDPAAQAQLDRGLRMVEVLKQQQFSPLSIGEQVVSILAGSTRMLDDIRTDDVLHFLTEMLSWMKLEAPEYITEVNESGDLTDEMRESIVSAIEAYKTIYRFSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC9</accession>
    <name>A0A1U9NNC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69307">
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        <property type="gene ID" value="STSP2_02496"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02496"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18855" checksum="7E93CDC87902AF06" modified="2017-06-07" version="1">MTRYKHKILGFLFAAAICSTFIGCKETSTRQSTSTSELLKGLANLKGYALINCKFTIESERKRDILPAPSDFKVIIRGYADLSQAGMLSLKNDYSFEPIDRNMLPVKLNEIVPPGKLLYSKEFNNTFSSNKPMYYNGFVVIRQNDEKNRVYFLTTDLDHDLKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM9</accession>
    <name>A0A1U9NNM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29830" checksum="2FA5AC889BB9862B" modified="2017-06-07" version="1">MIKCDNWPTGVCSWSASDNLETLGQLRSELGLEHLHLHAVPAIGSEGDKFLRAIKEQGWQVTCTMVSFEQEDYSTLDAIKRTGGIVPDESWDENRQRVLRSIDVTADLGVQLLSFHLGFIDMEDEAYRTKLSERILLLADAAKAKGVRLLLETGQESASELRAFLESLNHDSLGVNFDPANMLLYDKGDPVEAVKTLGGLIEHVHIKDALAAQWGKETPWGDGDVDTQAFLTALKEIGYDGALAIERECGKSRFEDVKKAIDRLVKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN3</accession>
    <name>A0A1U9NNN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem I assembly protein Ycf3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69445">
        <property type="protein sequence ID" value="AQT69445"/>
        <property type="gene ID" value="STSP2_02635"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02635"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011984739" evidence="2">
        <location>
            <begin position="24"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="390" mass="43108" checksum="33F4F4778F61379D" modified="2017-06-07" version="1" precursor="true">MNKALIFLLILAGVWGPAGIAAADWDSVNRDVIEVYARGEYKTALGLAQKALTVSKEEFGASHANTAKSHNNLGLILKQLGQYERAARHYRKSLAIRKSLSGEGSLAATTSMNNLAQLLKTMGRYAEAETLLMESLRIRLANLPPQHPHVMTSRNNLAGLYLVKGAYDRAERIYLTVLQDCRESGNRDIRLAQALNNLASVKIAQQEYVAALEMQRKALGLARELLPYRHPLIAAYMQNLALCLEQTGDYKEAEAYAENAVDILEDIHGPDHPAVAKALNNLAGINHKQGQFADAIGRYSRSLEIIKQKFGAEHPEAIKVCNNLAVGYIEKGNYEQARKILSGAVEYDSSYLRNSDGLLKSILDSLIKCCDELGKTSEAKAYRQRLDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP5</accession>
    <name>A0A1U9NNP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69572">
        <property type="protein sequence ID" value="AQT69572"/>
        <property type="gene ID" value="STSP2_02765"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02765"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24687" checksum="21885EC3037F5A63" modified="2017-06-07" version="1">MLSFLKEQSAGKPENNENAADVSSQSESKQDYLKPSANEKTVKQTTMLLMVLFTVGAGALWFMIKKTVPAEADAATAPKEQMEIETALAQLTGIKDEMNKNMGQIVDRFHQFSDIEQISVSELKKNPFKNELLLDQVTAAKETNSDFEQSKAKIVTEKVNEQAEQLKLWSIMESPKGSCCMINEKILYEGDSINGFEVKKITSESVELESQEVPVTLRMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ3</accession>
    <name>A0A1U9NNQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69364">
        <property type="protein sequence ID" value="AQT69364"/>
        <property type="gene ID" value="STSP2_02553"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02553"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="37512" checksum="9C00B670CDF6C655" modified="2017-06-07" version="1">MKNTGNKFWAASLIWVLSLLIFCGFSYAIIWHPESEPTQEWIDRPADKLIGRWGTNGSCVPISPWHVVTTRHQGGSAGSTSIMIDGKQFGIVKIWNHPTADLRIARVDKRLSGYAQVYRKEDENGKNVVVAGYGDGRKDILSTDGYTYGYSWDNSTNSTLRFGTNLIEEITQTPKGAPLPSELVVIRFNDPDATDYECAIADHDSGGGWFIYEEDVWKLAALSRGVEHVGESLFRDAQRPKQWADPDFCHGVRLSQYVSWISGVLGGDLVEVDCDLNGDRLVDYSDWNHLQECWQRIDCDPVNGHCGGGDVDKDGCVDIIDVANFASQWLCETPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU8</accession>
    <name>A0A1U9NNU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_10</name>
        <name evidence="2" type="ORF">STSP2_02776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02776"/>
    <dbReference type="EnsemblBacteria" id="AQT69583">
        <property type="protein sequence ID" value="AQT69583"/>
        <property type="gene ID" value="STSP2_02776"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02776"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="14836" checksum="8157C7CB2852FDE6" modified="2017-06-07" version="1">MKRKGFTLVELMVVVLIVAILAAVAVPIIRGRIDAAKWSEGKAIMGSIATAIRTYAAEQGTNGTLPTSLDDLGFASGDCTGTYFTDSDFQISVSSLGGGTGDDQYVQFSITCPGGSQTNAPGTPENGYVLTANSDGTMSWAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP33</accession>
    <name>A0A1U9NP33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02750"/>
    <dbReference type="EnsemblBacteria" id="AQT69557">
        <property type="protein sequence ID" value="AQT69557"/>
        <property type="gene ID" value="STSP2_02750"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02750"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165679" evidence="1">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="2">
        <location>
            <begin position="397"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="818" mass="93379" checksum="C7538FB160B6DCA8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC2</accession>
    <name>A0A1U9NPC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69356">
        <property type="protein sequence ID" value="AQT69356"/>
        <property type="gene ID" value="STSP2_02545"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02545"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36956" checksum="6B3048BDB57EC77A" modified="2017-06-07" version="1">MAVKARIKHIGAELKSHAPFTFFGALLGVAFMLLFKNATEYGETTLFRIFHPMHVVLSAMVTASLFKVHKNTKNFLLVLVIGWVGALGVATLSDSLIPYMGETVLGVAVPTHGDLHEGHTEHEEPEGVEDGHAGHDHEQAAHQESEHDGHDHGAAADVEGHAHEYAGLDHEEEEHGEPHNEHAGHYHDEEAAHQEHLEHEEHAGHGHAETDHEEAGGHEGHDHDGGLHIGFIEDWYIVNPAAILGVVIAFWLPATRMPHGLHVLISTWASSAHMLMNTQADFTATLLLGILIVLFLAVWLPCCISDIVFPLLFVKSDIKVCSHCHGKHHDPNSCEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF9</accession>
    <name>A0A1U9NPF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69803">
        <property type="protein sequence ID" value="AQT69803"/>
        <property type="gene ID" value="STSP2_03000"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03000"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="PTHR13572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="43265" checksum="4A4494355AFB4A31" modified="2017-06-07" version="1">MAEKIPEPVADAPAKISVGTYYYPWYIRSKHKWKQAMRLHLRTPQIPKAGLYDSRNPSVIAEHIEQSVRAGIEFWAVSWWGPDESTDRNFKDHILTHPEASKLKYAILYESTGRFGSFKNPDYSNWMDDMRYLKDQYFDNPNYLKINGRPVVFVYLSRVYFRGRGADALEQMRRELPEIYLVGDDVFYGDSTSVYKSEWAKNFDAVTAYDVYGQSISKLGGTQKAVQFLAHNYQQAKQAANSVGTAFIPAIAPGYNDTAVRDGHPGRARYFTDTPDSQPGDIFRAMIRKAAIPNTDPSCDNIIMVTSFNEWYEDTQIEATSGTAPPSKTDDSESGTYYTGGQTYYDYGYLYLDILRQEIEKSFMVTEGLNGTCNGKLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG3</accession>
    <name>A0A1U9NPG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arylsulfatase</fullName>
            <ecNumber evidence="8">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atsA_21</name>
        <name evidence="8" type="ORF">STSP2_02996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02996"/>
    <dbReference type="EnsemblBacteria" id="AQT69799">
        <property type="protein sequence ID" value="AQT69799"/>
        <property type="gene ID" value="STSP2_02996"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02996"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032158">
        <property type="entry name" value="DUF4994"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16385">
        <property type="entry name" value="DUF4994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387311" evidence="5">
        <location>
            <begin position="24"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4994" evidence="7">
        <location>
            <begin position="386"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="56570" checksum="EBD3BF00CFFDC3EC" modified="2017-06-07" version="1" precursor="true">MNRRTFLKNCALTVGAASFSGCAGMTGPSDKPSSASDRPNIVYILADDLGYGDVSCMNKDSKIHTTNMDRLAAEGMIFTDAHAGAAVCTPTRYGILTGRYCWRSRLKKGGIWGDSPPVIEKDRMTVASMLKPYGYHSACIGKWHLGWHWQMKDDNPEQIDFTKPIQQGPTTNGFDYSFCLPASLDIPPYVYVENDKVTAPPNRVVEGKTGKLLMREGPTGADFVHKDVLPDLTEKAVTYIDQRSESNKPFFLYFALPAPHTPILPTEQFRGKSGTNEYGDFVLQVDHTVGQVMRALKRNGLKENTLFIFTSDNGCAPHVNFEELAEYGHDPSYLFRGHKADIYEGGHRMPFIARWPKRVKAKTRCSDTTCLTDLMATAADINGIDLPDSAAEDSVSMLPNLLRTATGPLREATVHQSVNGSFSIRQGKWKLILCPGSGGWSPPRPGSPKIKDLPPVQLYDLSSDIDENENLHAQHPEIVRRLTNLLQSYIDRGRSTPGQPQKNNGKVPIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR6</accession>
    <name>A0A1U9NPR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02903"/>
    <dbReference type="EnsemblBacteria" id="AQT69708">
        <property type="protein sequence ID" value="AQT69708"/>
        <property type="gene ID" value="STSP2_02903"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02903"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="572" mass="64785" checksum="5272D37ED62117AC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT3</accession>
    <name>A0A1U9NPT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase inhibitor YacG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">yacG</name>
        <name evidence="3" type="ORF">STSP2_02924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GyrB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA gyrase inhibitor YacG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02924"/>
    <dbReference type="EnsemblBacteria" id="AQT69728">
        <property type="protein sequence ID" value="AQT69728"/>
        <property type="gene ID" value="STSP2_02924"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02924"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="62" mass="7197" checksum="53AB19B7EAFDB224" modified="2017-06-07" version="1">MTFRCPTCKNPLPDRKGKDKKAQNARKFFPFCCERCKLVDMGAWLDADYRIPVINADEEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW4</accession>
    <name>A0A1U9NPW4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ORF">STSP2_02955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02955"/>
    <dbReference type="EnsemblBacteria" id="AQT69758">
        <property type="protein sequence ID" value="AQT69758"/>
        <property type="gene ID" value="STSP2_02955"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02955"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30073" checksum="A7EE3E07513363C5" modified="2017-06-07" version="1">MPDKITIADLLGMRNAGRKITSVSCYDYTTAKLAAEAGVDMILVGDSAAQVILGHDSTLPVTMDFMVQITAAVKRAAPNLCIMADMPFLSYHTSIADAVRNAGRFIVESGAATVKIEATAAQLDVVKAVSDAGIPVTAHIGIRPQSVVKLGKLKAQGTTADMAFDLITLSDKMVKAGASMLLIEGTAREVAKIITERSPVPVISCGAGPDCDGQILIISDILGLSSGPMPKFAKSYADLATPTRDALRRYADEIRESKFPDDGLCYHVKPGEMEKLGQMMRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ39</accession>
    <name>A0A1U9NQ39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70051">
        <property type="protein sequence ID" value="AQT70051"/>
        <property type="gene ID" value="STSP2_03253"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03253"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="17306" checksum="E3C3F8ECA0B00D52" modified="2017-06-07" version="1">MSAKKMSITKPIVSITEICEMLQLSRSRYYQLVDSGFFPKPLRDEKSKRPYYDAALQKQILEARKTGIGVDGSFMLFYSPRKNESSRPMFKKKKQADPVAQELADILAGMGVEAAFEEVQKALNKLYPDGTEGMDQGIVTRELYRYFKQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA9</accession>
    <name>A0A1U9NQA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR repeat-containing protein YfgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yfgC_3</name>
        <name evidence="8" type="ORF">STSP2_03327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70123">
        <property type="protein sequence ID" value="AQT70123"/>
        <property type="gene ID" value="STSP2_03327"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03327"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="58"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26493" checksum="6ADB453B3169A8E9" modified="2017-06-07" version="1">MSLFYSLGKKLGPKVRKGKWVWQNIAGTQAEAIAAEYDVGKDLAAQALGSVKQVNDDKTTQKLEEIGEKLRKSLRNQERRFSFYLISDPKPNAFALPGGFIFVTDSLVKLCDSDESELAFVMGHEMGHVIKGHSMERLLSHSAIKTISRAAPGGIAAKGWIQQVGVKFLESAYSQDNEHEADQIGAKLILAGKFDRSAPEKLLGRLAKLGKEGNGLSVYFSTHPPARERIAVVKRVISQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB7</accession>
    <name>A0A1U9NQB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase</fullName>
            <ecNumber evidence="2">4.1.2.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xfp</name>
        <name evidence="2" type="ORF">STSP2_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03335"/>
    <dbReference type="EnsemblBacteria" id="AQT70131">
        <property type="protein sequence ID" value="AQT70131"/>
        <property type="gene ID" value="STSP2_03335"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03335"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047905">
        <property type="term" value="F:fructose-6-phosphate phosphoketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XFP_N" evidence="1">
        <location>
            <begin position="69"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="821" mass="91796" checksum="A5ACCA053B81BCE7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG4</accession>
    <name>A0A1U9NQG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70172">
        <property type="protein sequence ID" value="AQT70172"/>
        <property type="gene ID" value="STSP2_03377"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03377"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27723" checksum="95BE8DA3F4ACAAF9" modified="2017-06-07" version="1">MTYKAIKNTTFITAVLSIFIGAIWWFLFPPASRGLKNPMTRKYTLLKLIRRNSISNLPEHFSCDGNADVKYYEATDKNKSTYHLVTVTYDVAGLGDRSYSFVFDSEGKCLLRSKDRPRFDNGSMFDITNDGYIEKVFIYNIDDMAGDFDDISAMDKAIKVWRLSENPELLLHIEFKDEIAHESGGPFGYQIMAIVKDQRVELVSLELNEVFASFSWSAEKEQFVCQDFHPTSIWQVLCPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI4</accession>
    <name>A0A1U9NQI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase KanE</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kanE</name>
        <name evidence="3" type="ORF">STSP2_03397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70192">
        <property type="protein sequence ID" value="AQT70192"/>
        <property type="gene ID" value="STSP2_03397"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03397"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="390" mass="43209" checksum="01EFC9021DF3A732" modified="2017-06-07" version="1">MKIVHIITRLILGGAQENTLITCRLLAEHGHDVTLITGPALGPEGHLYDWTRNSGFETIVVDEMRREIAPRLDRRAYKKIKRLLTELKPDIVHTHSAKAGILGRFAAHRLKGKFGKPGFPKVVHTIHGLAFHDYQAGHLNALYIAIERAAAKRTDAMLTVADTMSEKALAAKLGTPDMYTTAYSAIEEDAYLAHPGQQRIADFRRKYGLSSESVVLATVARLAELKGHEYIIESAKKLASRFPDCTWLFVGDGHLRSDLQQQIQLANLSYRFKFAGMVDPSDIPMVMHASDILVHCSLREGLARALPQAMLAGKPVVSFDIDGAKEVVTPETGRLIPPEDVPALTEACAELIADPNLRRQLGQNARKKVTKQFAPETMVDTIESLYRKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM7</accession>
    <name>A0A1U9NQM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-2,3-diacylglucosamine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03329"/>
    <dbReference type="EnsemblBacteria" id="AQT70125">
        <property type="protein sequence ID" value="AQT70125"/>
        <property type="gene ID" value="STSP2_03329"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03329"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="33276" checksum="221B3E5795BC20C4" modified="2017-06-07" version="1">MSDNSRDIFVISDLHMGDGGPRDNLATEGKESQIDRFLDHVAAEDGELIILGDLFDFWQAHVGNVLALRKNYLDRFAEMGATYVTGNHDADLEALIGTDFLKHPFFERMVGPFERTIGGRKFKFIHGHEVEPFSSYDTPGWGRIFAILVGIMEDKKGSPLLSAGGLGERSMLGLSRVFMGLWNLFVNSFEKTKKRKKTHPHHVEDELTPAQRPEHTKKIVSLFRKHLEENGYDAIIAGHTHRVGSLGDWYFNSGCWVGMRENFLKISPEGEVVVYDWTDDGPVARKGNNQESVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP3</accession>
    <name>A0A1U9NQP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">STSP2_03458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03458"/>
    <dbReference type="EnsemblBacteria" id="AQT70252">
        <property type="protein sequence ID" value="AQT70252"/>
        <property type="gene ID" value="STSP2_03458"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03458"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23721" checksum="7976CFDD330EEFA2" modified="2017-06-07" version="1">MKDEKQNKDKEKSPKSSREDKKAAKKVEQLEEQIEKLEHEKSQLFEQLQRVSADYANFQKRAPKQIADSVAYEKKAIIKSLLPSLDNFGHALAGLEDADENVKNVLQGVKLVFDHMLDALRAHGVEQIDALGEQFNPSQHEALMQRFEEDKPDNVVVEEYQKGYALNGQVIRPSKVIVNKRPEETEDTEEVEKDLPAEDPQSGQPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ6</accession>
    <name>A0A1U9NQQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative efflux system component YknX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yknX</name>
        <name evidence="5" type="ORF">STSP2_03467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70261">
        <property type="protein sequence ID" value="AQT70261"/>
        <property type="gene ID" value="STSP2_03467"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03467"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798479" evidence="4">
        <location>
            <begin position="29"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="538" mass="59602" checksum="1257A77AF9A79F59" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT0</accession>
    <name>A0A1U9NQT0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ORF">STSP2_03475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03475"/>
    <dbReference type="EnsemblBacteria" id="AQT70269">
        <property type="protein sequence ID" value="AQT70269"/>
        <property type="gene ID" value="STSP2_03475"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03475"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="189"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="507" mass="57514" checksum="42E917AC28E90518" modified="2017-06-07" version="1">MLAALFYQNVNLSGFEGDNKLAEQSSMDQYQQQRQEKLNKMIELGVDPYGGRFDDVIPAEKIKADFEDDKEGQRACAAGRIVLLRDIGKLMFVTLRDSSGTIQLGLSKKMLADQWPLCKLLELGDIVGAEGEVGRTRTGEITIWAEKVTILSKSLMQPPEKFHGLTDPDARYRMRYVDLWANPEVLERFRKRSEIVASMRNFLQERGFLEVETPMMQTIAGGAAAKPFITHHNTLDMDLFLRIAPELFLKRLLVGGMERVFEINRNFRNEGLSTRHNPEFTMMELYQAYGDYNAMMDLTEEMVTSLVEKHCDGMELPFGEMTVNYSGPWRRARYADLLKECAGVDIDDIEAVRAKARELEIGESHMDDAVVINEVFEETVEDTLIDPTFVIDYPAELCPLTKRSKADPRYAERFELFIGKMELANAYTELNDPKVQEDNFRTQLDGQEDTMATMDEDFVTALKYGMPPAGGLGVGIDRLVMLLTGATTIRDVILFPLLKPAARSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW8</accession>
    <name>A0A1U9NQW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1936003.STSP2_03382"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
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        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="175"/>
            <end position="196"/>
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            <end position="233"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="564" mass="62803" checksum="16A078C54AF8D160" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX1</accession>
    <name>A0A1U9NQX1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="13" type="ORF">STSP2_03421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03421"/>
    <dbReference type="EnsemblBacteria" id="AQT70215">
        <property type="protein sequence ID" value="AQT70215"/>
        <property type="gene ID" value="STSP2_03421"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03421"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="168"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="821" mass="93153" checksum="DCFDF6FB9B12E027" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY0</accession>
    <name>A0A1U9NQY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03538"/>
    <dbReference type="EnsemblBacteria" id="AQT70332">
        <property type="protein sequence ID" value="AQT70332"/>
        <property type="gene ID" value="STSP2_03538"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03538"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22385" checksum="FAA0B6D0C42AFC53" modified="2017-06-07" version="1">MKCDNYMNMQSIATTHASQVADLHIQGISTGFISSLGPRFVTALYEAIAQSPASFGIVAVEDDTVLGFVTFTTDVKALYKILLRKHGLKFAVLLAGKMLSPSRLKKIFETLFYPAKAETRDLPSAELLSVVVSPQARGKGLARKLIEEGLSQCRQRQIEKVKVLVADHNKPANKLYQTCGFEYATSVDSHGTKSNIYVADLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQY8</accession>
    <name>A0A1U9NQY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative teichuronic acid biosynthesis glycosyltransferase TuaC</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tuaC_1</name>
        <name evidence="3" type="ORF">STSP2_03539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03539"/>
    <dbReference type="EnsemblBacteria" id="AQT70333">
        <property type="protein sequence ID" value="AQT70333"/>
        <property type="gene ID" value="STSP2_03539"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03539"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="393" mass="43926" checksum="D30DC9FD3E18C97C" modified="2017-06-07" version="1">MTNVKRTKPQKHICILASVPVTIWSFYRQLVADMVSDGTKVTVIASEGEELGWLSNECGCSTKAVEIKRRIDVLGDLKSFLKLSKFLFLEKPDMMHAHTPKGGLLGMLSAFFAGCKKRIYTVHGLPMDTATGLKRKLLWAVEWLSCKLATKVLAVSPSLKKRMIEEKLCNKDKITVLNHGSACGIDLSRFKPDSARGPEVRKKLGIPTSAFVIGFVGRIVNDKGVSHLVRAFEVLQKDFDDIWLMLVGDFETVRDSLDPRTAKKIDDNGNITCSNGFIKDIVPYYAAMDMLALPTKREGFGLVLIEAAAMKLPVVATRVTGCVDAVDEDVTGRLVEPESLTELTEALRDLLENSDERNRLGQNGFRRTHEKFDSIQLVKVHLKFYDHLLNEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ1</accession>
    <name>A0A1U9NQZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar transferase EpsL</fullName>
            <ecNumber evidence="4">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">epsL</name>
        <name evidence="4" type="ORF">STSP2_03535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03535"/>
    <dbReference type="EnsemblBacteria" id="AQT70329">
        <property type="protein sequence ID" value="AQT70329"/>
        <property type="gene ID" value="STSP2_03535"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03535"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="23117" checksum="D18CB407D08CA5B3" modified="2017-06-07" version="1">MYLFVKRAMDIVLTLPAVLIASPVLLVLIVAIRLSSKGPAVFKQERAGKNGKPFTIYKFRTMRLDADPYGPSPKSGRDPRLTGIGIFLREHSLDELPQLINVLKGDMTLVGPRPLYVSQMEEWNETQKRRLLVKPGLTGLAQVSGRGGLTREQKLALDVEYVDNACLSLDLRLIMATFKQVLGRQNIYEKRYSETEQTRNADNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR28</accession>
    <name>A0A1U9NR28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70178">
        <property type="protein sequence ID" value="AQT70178"/>
        <property type="gene ID" value="STSP2_03383"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03383"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="952" mass="103570" checksum="69D8E05158FAFF77" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR36</accession>
    <name>A0A1U9NR36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lpxB</name>
        <name evidence="10" type="ORF">STSP2_03393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03393"/>
    <dbReference type="EnsemblBacteria" id="AQT70188">
        <property type="protein sequence ID" value="AQT70188"/>
        <property type="gene ID" value="STSP2_03393"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03393"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="385" mass="43498" checksum="CD7FC6C2BC639F67" modified="2017-06-07" version="1">MKKRIFISACEPSAELHCANLIDTVNAKVAANENAYDHVTEIEWVGLGGEKMSSAGCELIENTVSRAAMIYNVFGQIGWYWKLIGRVKRYFKENKVDLCIVCDSPAFNFHIARAAKKAGTKVMFYVAPQLWAWAPWRIGKLRRLCDKLACILPFEKDWFAARGVDAEFVGNPLLDELDGNIREAYKNYFDYEPGTANVALLPGSRDAEIETLWPAMQDVGLMLREKWPGVRFTTAAVSEEKLAALKEMQFEEFECEYVIDDVPGLARRSDMAMVASGSATLQVAAAGCPMVIMYQSNPWMWHLIGRWLIRTRHLSLVNILAKREAAPEYMPYFRDIEPIYERCVGLLSSKSRLNRMSSDMIGIAEPMAKTHTASRVAELAIEMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRK1</accession>
    <name>A0A1U9NRK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">STSP2_03360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03360"/>
    <dbReference type="EnsemblBacteria" id="AQT70156">
        <property type="protein sequence ID" value="AQT70156"/>
        <property type="gene ID" value="STSP2_03360"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03360"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14129" checksum="5BB4BFCDD56C45FA" modified="2017-06-07" version="1">MVVDGLYYTKEHEWVKVEGSTATVGIADHAQEALGEITYVELPEVDREVSAKDELAVVESTKAASDVYSPISGKVTEVNEALEDEPEKVNEDCYGEGWIAKIEMSDASEVEQLMTSDQYKDFFKDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG84</accession>
    <name>A0A1U9NG84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66939">
        <property type="protein sequence ID" value="AQT66939"/>
        <property type="gene ID" value="STSP2_00077"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00077"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387300" evidence="1">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="212" mass="24263" checksum="986B3FF78C7D7332" modified="2017-06-07" version="1" precursor="true">MTYKSKILALAAISAILPLAGCKVLVAPDTTEPAITYYRNPYADLHRVGKVVLLEPENESAYPQISEDITAQLAESIYKKQIFGLRSLYRSDPAWQSVNIDGEGTYKEDQLELIRNSLGTDAIMYGQVLQYQPYPRMSIGLRLKLVDCHTGELLWAIEQVWDSTDGNVVERIKRFFETQMREGYKPMDWRMALKSPRIFNKFVAYEVAETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGA6</accession>
    <name>A0A1U9NGA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66963">
        <property type="protein sequence ID" value="AQT66963"/>
        <property type="gene ID" value="STSP2_00101"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00101"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16267" checksum="C1AF2EF76F0E8702" modified="2017-06-07" version="1">MAKKKSSGLTPKQLRVIEDLFTGVDEMEILRKHKLSRKVFRRWMDEETFMGELRCRMRSAKLQSEMVISRYAQMAAMKLVQLTDSEKEETARKACLDIISLPMPEDKPVEDADDVRLAEGLTTQMASRLLEVMAGGGKAKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT7</accession>
    <name>A0A1U9NGT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66954">
        <property type="protein sequence ID" value="AQT66954"/>
        <property type="gene ID" value="STSP2_00092"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00092"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010728254" evidence="1">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="346" mass="39199" checksum="F8D019EDE0C3F507" modified="2017-06-07" version="1" precursor="true">MFRHLIRLLLIMTVTMAAGCTIRLEKTAVKDQKLLSLPQINSNGYEKTSDDANSTSFKQLDYSEIRLPEPTRIGYESFYFDHINLIAVPGRLFNGREYSVLLDTGFPGYVLTNSLTVLENKLSVLPLGEADWYSAHMGVCEVPALYIGSAEIVEPPCMYVQMQWEVKVVGLPVWRQKGFLIGLGMLRNFSYVGFDNVSEEVELSAADAFEPDTPADWDSYPLKISDDKLFVEMPFYGRTMELMFDTCGRYGMIVGEKGFETLGLDKGSVDIRKTTFRSGFLGELPCRKARIKNLEIANLKIPSAELIILPENSPYMEAENSISMKFFRNTTVVLDFANERMWVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV8</accession>
    <name>A0A1U9NGV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="11">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cph1_4</name>
        <name evidence="11" type="ORF">STSP2_00314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67171">
        <property type="protein sequence ID" value="AQT67171"/>
        <property type="gene ID" value="STSP2_00314"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00314"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="531"/>
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        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67171.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1410" mass="160611" checksum="9DD76EDAAFCC7D36" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX2</accession>
    <name>A0A1U9NGX2_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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            <begin position="6"/>
            <end position="29"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67182.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37315" checksum="EDDD7067DC519E8F" modified="2017-06-07" version="1">MLGYGYITGLGVRIFFISLVLLSGGVQVLAGESDAKGQGCCATESEQCGKAGEKAWRVVEISDEVREERGLDEWYRKMVDVDGFTVAGSERVSDMALQEAAFIIDKMLTGLDDVRDAMIRTKVKCAVMAVDEFTTMVPEHATLEPADYWNRRARGLGAIKLRPAVSCGEENLLAMEGDPYRTQNILIHEFAHSMHLTGLSVCDRSFDTKLLQAHKGAVDEGLWKGTYAGKNHLEYWAVGVQCWFDTAGENDHVSNEINTREELREYDPRLYAMVKDVFGESQWKYSPPAERAGRGHLKDYDRSKLAKFEWPKRYDHVVKDIDAETAEIQGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH20</accession>
    <name>A0A1U9NH20_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <location>
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            <end position="78"/>
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    </feature>
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            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27493" checksum="10780307D87469A0" modified="2017-06-07" version="1">MQITVPKILQVEQFDPAQLDDPVAARTRWKMIGKGGFNLRHYHFKDVGTNRMELKPGMLALAFEVVFTWVGALIMIVGDYDFRSLIAIACGFLMGFLFVAAERIYYILWPSVFDKTSGWHYEGRKALHAVATMRDEERAGAVQLSSIHALQMLENRHNWCRQYELNLVLQDGRRVSIGWSRQKDHACKAADKLADFLEVPVWSNISDTVRSMRIAGRAVGSLKRRMGLRKNLKCSNGFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH29</accession>
    <name>A0A1U9NH29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">agaA_1</name>
        <name evidence="7" type="ORF">STSP2_00372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67229">
        <property type="protein sequence ID" value="AQT67229"/>
        <property type="gene ID" value="STSP2_00372"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00372"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Melibiase_C" evidence="6">
        <location>
            <begin position="418"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="54730" checksum="0BB8F4930D9983A6" modified="2017-06-07" version="1">MYSRISVAVLGLIAICLTGCGHKVMSRTSHPLSPKINAPYRVGIHPGTPFMHAVGTSGPEPMHYTADDLPEGLRIDPQTGIIRGVIEDAGTYTPTITAENKYGRATRQIEIVAGDTLALTPPMGWMTWNKFQGDISEQLIMEIADAMVETGLRDAGYEYIIIDDLWQGKRDEDGNIQPDPEKFPSGIKKLADYVHAKGLKLGIYSDAAEWTCAGAIGSLGYEQQDADTFAEWGIDYLKYDYCHAPKDVETAKKRYSKISDALDATDRSIVLGICEWGPRKPWLWGREVGGNLWRTTWDIRDTWDAGSYSAGCNGIVQTLDRHTDIADHAGPGGWNDPDMLIVGLYGKGKPSNACGASGCTDREYRSQMSLWCLLAAPLTISCDVRDMTPETRYILTNDEAIAIDQDPLGEPARRVHKDGPIEIWARPLADGSWAVGLLNKHDEEAKDITFDYAMVDLEGTAEVRDVWAHMDMGEFTDSYTDKVEPHETKLIIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH54</accession>
    <name>A0A1U9NH54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_00068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66930">
        <property type="protein sequence ID" value="AQT66930"/>
        <property type="gene ID" value="STSP2_00068"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00068"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20451" checksum="8ADBB827D9B49B43" modified="2017-06-07" version="1">MADEEKKKKDTKEKKRPCLLGHIITAVISLTFAAGGYFVSGLFADTKPQGEQAAEEKKEDPSAEINALLAESTEGSKPWTYELEPVVANLNEPGATRFVRATLIMEISGDMAQEKGKEFLGLKTPYLRDWLTTFLSSLTLDEANGGKNKERIKNLVCDEFNRRLFPDSKPLIKQILLKEFAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG2</accession>
    <name>A0A1U9NHG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67349">
        <property type="protein sequence ID" value="AQT67349"/>
        <property type="gene ID" value="STSP2_00493"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00493"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24934" checksum="C8EADBA7BC76B2CC" modified="2017-06-07" version="1">MKLFAGMSKQRRKDIWELMVFVVLGFGLPVMNWVFMYLAGCELSQEYFMWAGSVLVGLLILPIVGLHFFITQMARAIRKAFKKDWQAAGSACGFVILGIIAAGAWLVFPPGVTPLIGGLERAAEEKLEVESICDWMEKEAEALEARRHIVNQGERPKFIGKLNPAHVFLDKFEGGSVQVKLTWGGPLLHYGYIIGENLSEIDGAKDYERWVVVNDNVIIWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP1</accession>
    <name>A0A1U9NHP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="3">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wrbA</name>
        <name evidence="3" type="ORF">STSP2_00599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00599"/>
    <dbReference type="EnsemblBacteria" id="AQT67452">
        <property type="protein sequence ID" value="AQT67452"/>
        <property type="gene ID" value="STSP2_00599"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00599"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22467" checksum="822ACCB2D01BC9E7" modified="2017-06-07" version="1">MKILIVYYSLYGHTLKLARAAEQGASQIENAEVIFRRVREFPETEVDMPNHPHADKVWQQQKDTPECTLDDLKAADGIIFASPTRFGNMIAQMKRLFDSCASLWMEGALEGKPAGVLTSTASTHGGQETTLVSMMIPILHLGMVVVGCPYSIDGMIHTEARGATPYGPTTLAGPDNSREPHEQDIEIAKQYGKRFATITAKMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ5</accession>
    <name>A0A1U9NHQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00431"/>
    <dbReference type="EnsemblBacteria" id="AQT67288">
        <property type="protein sequence ID" value="AQT67288"/>
        <property type="gene ID" value="STSP2_00431"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00431"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="42575" checksum="1AD160E62425DEB7" modified="2017-06-07" version="1">MARIVYGIAGEGFGHSSRAHLISKALIEAGHDVMFAVFDKSLRYFRQYYPAQVREISGFQFVYQHDKVSLSRTLLRNVHKFPTMVGRNIRVFWGDCARFDPDLVITDFEPFSALWARVKSIPCISVDHEHLLCNCRYEKPAASMLTSYISEKVTSQYLGSNVDKYVVLNFFKAKRTDRQTVVTPPVLRPQVLEQSPSRGDHILCYVTSAQMKEHFLRVCRRFPEQKFVIYGMDSAGSIDNLHFRERSTENFLTDLASCRGIVATAGFSLISECLHFGKKMLLNPVQQQYEQMVNAHHAARLGAAMTTDSLNEKVLADYLDFLKTPLPENENILLPDNELFFKKLDRVLNVLTAGRVSVRPAAKTDNAKLEPVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX2</accession>
    <name>A0A1U9NHX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 69</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhdN_2</name>
        <name evidence="2" type="ORF">STSP2_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00559"/>
    <dbReference type="EnsemblBacteria" id="AQT67415">
        <property type="protein sequence ID" value="AQT67415"/>
        <property type="gene ID" value="STSP2_00559"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00559"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="381" mass="43169" checksum="1272DB76E3638788" modified="2017-06-07" version="1">MIYSDFGKTGAKVSAVGFGGMRFDTKNKSNEENAELLTYAVDKGINYLDTAPGYCDDKSEDIYGLAIKEMADKRDQFYVTTKGMPATYDTADKAREAVEKSLKRLNTDYIDFYHVWCIRRMSEYELAMKPGGQYEGLLKAKEEGLIKNIVISSHLRGDHIAQIMKKKEYEAVLLGLNILNFMYRWEGVQKAHDLGYGVVAMNPLSGGLIPKHEKEFSFLGEEGESATEAALRFIISCPQVNVALVGFENKEHIDMACRVADQAKSFTEEDIERVKANLSDHMNSLCTGCNYCMAGVCPQNIPIASYMQYYNDKPLFGKDEQEMKKKLKFELEWGRLAEKVSRAKDCIECAKCEQVCTQHLDIMNRLAEIAEWRTNLPEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY1</accession>
    <name>A0A1U9NHY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosose isomerase</fullName>
            <ecNumber evidence="3">5.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolI</name>
        <name evidence="3" type="ORF">STSP2_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67425">
        <property type="protein sequence ID" value="AQT67425"/>
        <property type="gene ID" value="STSP2_00570"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00570"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012821157" evidence="1">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33875" checksum="9E426D6ECC6F8181" modified="2017-06-07" version="1">MAKIQPLRTFFFVQFLCIALLLCSCSARQSAKLKNEPFSPKIGVCTSKADSQFMERAGLDYIESSVRGFLVPTKEEDVFQAANRKYEEEGVKTYACNGFLPGSLKSVGPDAKHDEIITYCETAFRRAEEAGVKYIVFGSGASRRIPDGFDPTRAREQFVELLGRMGPVAGKDGVTVVIEPLRSKECNFINRVDEALAIAKDVHHPNIRVLADFYHMMQEGEGPESIIAAGEYLRHCHIAENEGRWYPGKNGEDFTPYLQALKDIGYNGGISMECRWSDFPNEVGQAVDFLEMQIEAVKVSPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY3</accession>
    <name>A0A1U9NHY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67539">
        <property type="protein sequence ID" value="AQT67539"/>
        <property type="gene ID" value="STSP2_00687"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00687"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527451" evidence="1">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="44431" checksum="AD6FB706D63B3A41" modified="2017-06-07" version="1" precursor="true">MKLNLIVVPVLVVVALLTGCSNSQTSNERTFGEDVAFLKDHTETVVLSDSTGQAKIAIVPAYQGRVMTSTAGGDNGASYGFLKYDLIASGETKPHINPYGGEDRFWLGPEGGQYSIFFEPGDPFDLEHWQTPAFIDTEKYEVAVRKDNSVTFIESAELTNYSGTSFEFGVFRQISLIERPLVTDFLGIAIPDSLDVVAFQSSNMLTNQSSTEWTKKDGLLSIWILGMFKHGPKTTVVAPFHPGSKDKLGPIVNDAYFGKVPNDRLTIKDGTVFFLADGQYRSKIGLNPMRAKPVVGSYDPDRKVLTIVQYTKPAGATDYVNSMWEIQEQPYGGDAVNAYNDGPAEPGAEPFGPFYELETSSPAAALAPNESLSHTHRTFHITGPENDLDPIARAILGVSLEQIKNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ2</accession>
    <name>A0A1U9NHZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Negative regulator of genetic competence ClpC/MecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clpC</name>
        <name evidence="9" type="ORF">STSP2_00701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00701"/>
    <dbReference type="EnsemblBacteria" id="AQT67553">
        <property type="protein sequence ID" value="AQT67553"/>
        <property type="gene ID" value="STSP2_00701"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00701"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="423"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="837" mass="94070" checksum="7C79B040FE7AFD0C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ9</accession>
    <name>A0A1U9NHZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00531"/>
    <dbReference type="EnsemblBacteria" id="AQT67387">
        <property type="protein sequence ID" value="AQT67387"/>
        <property type="gene ID" value="STSP2_00531"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00531"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="1">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="168" mass="17739" checksum="A0D98F496BD0ED14" modified="2017-06-07" version="1">MRSTELLLLAVAVSATVLVAGCGGNESLDGSVVSMEGLTAEPVELEGAVGRGRTRIEELVRLRDEAGKIKGYAAVAVVRSKSGRFPIRVRLDESGCVESAEVLSYPYDRGSGVILPTFTGQFEGRCSPEQLTMGQEIQAVTGATVSCGAMAEGVIDVMSMVRKIKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI61</accession>
    <name>A0A1U9NI61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67467">
        <property type="protein sequence ID" value="AQT67467"/>
        <property type="gene ID" value="STSP2_00614"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00614"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012007529" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22610" checksum="8D4570CC0B9F9F67" modified="2017-06-07" version="1" precursor="true">MKRSILLLFVVMFAVSAQAGVSLTTTGNSDGMSRYYRTAGWSPYTSYSEGNITDTVLNGQKDQSYPDYWAYVPVLEFNMSDYNGTAAEITAATLNVYMPTAGSGTIGVKYAGEADGVIDYDSRSGTKIAEFNAATTVGWYTLDVTDQIKEAVENSYGWVGFVIDPDSYGDQVNVAAYESGNGASIMVVPEPATMLLLGIGGLATVRRKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI69</accession>
    <name>A0A1U9NI69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wapA_5</name>
        <name evidence="2" type="ORF">STSP2_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67438">
        <property type="protein sequence ID" value="AQT67438"/>
        <property type="gene ID" value="STSP2_00585"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00585"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMOP" evidence="1">
        <location>
            <begin position="215"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="42593" checksum="F2E8AD706CBBC88C" modified="2017-06-07" version="1">MAKKQDYAIILCKFDYDALGRRIRRIKHDISETRLYYYNDNWQVLEEYECVSLHGTTMVNRYVYGNYIDEVLRKDDGTDAYYYSQDHLYSPVALLDTNGTVVERYEYNAYGKATVYTDKGTDGTWLTADDTTSTISALDNEYTFTGRRLDSLHANQLPLMYYRHRYYDPQMGRFLTRDPLGYYLDGLNLFEYTKSLPLNRLDPSGLFYMVPPHVPKPSPEELCDDWIEDESDDMNWINDIPHCPTNLPCDGSNPDSDIWEDPKDADQKYHPGADKCIRGKYEDIESGQQCCYSEDGNLITDGLGAGTPDRISPVGGIKNIKGVRGHLWEDVRMYKYCKKHLGDDWVEEKYNKVRPPCLGEERCDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB9</accession>
    <name>A0A1U9NIB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67474">
        <property type="protein sequence ID" value="AQT67474"/>
        <property type="gene ID" value="STSP2_00621"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00621"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19451" checksum="B537B58B83ABE5A5" modified="2017-06-07" version="1">MDWVRILVDAGANVDAINTKFDELASKYDSTIVRGSSESKPPVYGRTPLQLAVSGGRLKVAEYLLMQGADVNKPTFQAADRADKEEIPPGLFPDLRGGPISPLHLAISSRMLSENETKMLKMAKLLIKYGAKVNAVCKLPAQLYAPASNSKQQAKEFTPYELALHLGFSRVANYLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG9</accession>
    <name>A0A1U9NIG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase (Contains TPR repeat)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67380">
        <property type="protein sequence ID" value="AQT67380"/>
        <property type="gene ID" value="STSP2_00524"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00524"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="464" mass="53478" checksum="18C482190EADB95D" modified="2017-06-07" version="1">MAGTQTGDDLEKALAFFERAEEVAASDNFDYAIEMYLEGLRRAPDALEQGHLPLRQLALKRQARGGKKPTVVEKMKHMGGKTPVEELVNASYLFAKDPDNTHYAETLLKAAVKGNYRRTAEWIAQLVFEANRASEKPSFATYMLLKDCYIKLQQFGMAVSACRHGVQMKPNDEALQLELRNLSAQMTMQKGKYNGKGDFTGSIKDRERQQELIEAERPRHSEDKKKEVVNQARAAYKENPDSVDNIVSLADAMFGLGTAQGHNDAILFLKRAYEKKGEFAIKKRWHELKMRRLRILIQLAKTKAKQEPENAKRRQDVMALAEQYNKEELRYWEACVEHYPTDLRMKYDYGICLIKNGLYDEAIPVLQEAQREPGKRVAAMDETGLCFFLKGWYQDAIDIFQEAFRLCEVRDSDLAKDIRYNLARSYEEDGQSEKALEYYRKLAQLDFKYKDVSQRVENLRKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII2</accession>
    <name>A0A1U9NII2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antilisterial bacteriocin subtilosin biosynthesis protein AlbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA_2</name>
        <name evidence="7" type="ORF">STSP2_00888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00888"/>
    <dbReference type="EnsemblBacteria" id="AQT67739">
        <property type="protein sequence ID" value="AQT67739"/>
        <property type="gene ID" value="STSP2_00888"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00888"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034480">
        <property type="entry name" value="Heme_carboxy_lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01385">
        <property type="entry name" value="heme_carboxy_lyase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="39"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="417" mass="46771" checksum="BE30E6F8A78EFBA1" modified="2017-06-07" version="1">MINITRLYCDEMTPGDWIRYGRNGHGTTGKTDKLPTSARRRKPIVVWNITSKCNLRCVHCYNDSGCDIKSNEATTSEAKAVLDDLADFGVPSVLFSGGEPLMRDDLFELIDHARDKGLRTVISTNGTLITPERAAKINELGVSYVGISLDGIGEVNDQFRQVDGAFDRAVAGIRNCQNAGVRVGLRLTLTKRNVQDLDALFDFFEQENIERACFYHLVPSGRGKDISDARLTHEQSRHAVNTIIERTAALSKQGRRTDILTVDNHVDGVYLYRKLNAYDCERAEKVWQLLTWNGGGMNSSGIGIGCIDFNGKVHANQFWGHYDIGDIHERKFSDIWTDESDPLLKGLRDRRSNIKGRCRLCKYFDACGGSLRVRADLYFGDTWAPDPACYLTDKEIGLDDAAIQELKRSGELYDMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ6</accession>
    <name>A0A1U9NIJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67568">
        <property type="protein sequence ID" value="AQT67568"/>
        <property type="gene ID" value="STSP2_00716"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00716"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013182898" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21630" checksum="70115F89A271845F" modified="2017-06-07" version="1" precursor="true">MLRTRFSVLMTVLVCCISIPAFSAFVSIDPDAYGDGVDVSDIYSDATLSSVGGYPGLDGRVYAVEDGFASTGTMVFGNNLGFGSQWSADNNLGFALRVDFHQNANSVAIDLIGDDASDSAIVQAYNAQGQLIAEERAYFIGAGQVVRAQLDRPEYDIAYITAGGLTINGQAETIHLDNIEANVIPEPASLLLLGLGAAVLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM1</accession>
    <name>A0A1U9NIM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="13">ACCase subunit beta</shortName>
            <shortName evidence="13">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="13">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">accD</name>
        <name evidence="15" type="ORF">STSP2_00785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00785"/>
    <dbReference type="EnsemblBacteria" id="AQT67637">
        <property type="protein sequence ID" value="AQT67637"/>
        <property type="gene ID" value="STSP2_00785"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00785"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30737" checksum="7017E1CC84D42482" modified="2017-06-07" version="1">MAKKTKSWDGYSLKPRKEMPEGLWLACPSCKEMLFRKTVDKNMGVCPKCEHHFRVDGWTRVNQLVDDGAFEELCSDLASDDPLNFAWKGNNYKDRLEKDRNKGVGNEAMICGKGYIRGRGVMLAVMNFNFLGGSMGLVVGEKLCAAVDQALEEDLPLVVVSSSGGARMHEGVVSLGQMAKTSAALAKFDDAGGLFISVLTDPTTGGVTASFAMLGDVIIAEPKALIGFAGPRTIYQTIKVELPEGFQRSEFLVEHGFVDMIVSRHDLRAEISRLVDYCGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN7</accession>
    <name>A0A1U9NIN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00942"/>
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        <property type="gene ID" value="STSP2_00942"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00942"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30469" checksum="ECEC454BEF722C1C" modified="2017-06-07" version="1">MIISLLRLTRLYYSLPLAGGFIVILSYLTAGNLSPAMNEIIPAFFSVLTIISAGYVLNDVCDVHIDRINCPRRTLPSRRLEPKPALIFSIMLFITGLSLAAFCGIAFFLTSAIVTVLLICYDLVSKRIGVFKDLFVAALMTSLYPLAFALLEPVDTPRLSVLYIHPAWLFFSSLGYEMLKDIRDAAGDSRNSPQPVYYSIRKSFAIASRLSIITASLITLLPFILGLCHEVYLVSSLTAVVLATLAAFSRPTVAIRYVYAEVALITAGSLVDLLVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR5</accession>
    <name>A0A1U9NIR5_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Serine endoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67715">
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        <property type="gene ID" value="STSP2_00863"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00863"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012707959" evidence="2">
        <location>
            <begin position="21"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="472"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="617"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="745" mass="82545" checksum="B25A6299678DBE39" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU6</accession>
    <name>A0A1U9NIU6_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Internalin-A</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT67853">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="418" mass="46374" checksum="DB192B092537F66F" modified="2017-06-07" version="1" precursor="true">MRRLLVFAVILVVSGAVFAVEQEAEDVRSIVEGIENAELREQLLEELEENPESDLSSIGLDGLNDLGGLEELANIETLGLAKSQEVDMSPVSELPSLGCLMLFDCTKILWNSDSLNTSCEVLVISKSDLKEIDFVSKLPNLKMISIRDSSVNDLSSIKALKGLRILSLKNFKGQKNLAFIGEMTSLKGLTIKGVEALKFPSFSKLRHLEWLDIADANSVDVRTINSRNTLRELYLKNDHISNISFLKRLPNIEIAHLDDNPIKDFRPLSALKKLKNVSLSNTGFSDFKVLGGMSELETVYAEGNGIASLDDAEELIGIKSLRLRNNKLKSLAGIKVLSSLTSLDVRDNRLSSIEEVAHLKKLGALCLSGNKIKSIAPVAELSELWFLQLDSKLPNMEEAQQVIGELRERNPDLYVWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW6</accession>
    <name>A0A1U9NIW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67727">
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        <property type="gene ID" value="STSP2_00876"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00876"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="72" mass="8068" checksum="09CE748BB0D139F0" modified="2017-06-07" version="1">MEFDNSGSLTRSYVHANAQVLSQDDYTQADPVTGEPNRYYYIHDRLGSVRIVYHPAMAEPINSYTGACPGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY2</accession>
    <name>A0A1U9NIY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01033"/>
    <dbReference type="EnsemblBacteria" id="AQT67881">
        <property type="protein sequence ID" value="AQT67881"/>
        <property type="gene ID" value="STSP2_01033"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01033"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25664" checksum="FBBC16D86546F7C3" modified="2017-06-07" version="1">MRADQIWQMLDGSMNSGEPVNAVQVLTAVLLSLVLGQVLAWTYFFTHSGLSYSKSFVQSLVLITVVIALVMSTIQNSFVTAVGLLGALSIIRFRNMIKDTRDIAFIFGALMIGMAAGSRRYDISIIGTIAFAGIAAYMHVGEFGAHRPHNGFLRFSLDGHMGADHPVGQVLKKFCRNFTLISAQDSDFDAPTVEYAYQVMIKNTGKNAEMLAQLEELESVSNVSLTMQEQLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY6</accession>
    <name>A0A1U9NIY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00896"/>
    <dbReference type="EnsemblBacteria" id="AQT67747">
        <property type="protein sequence ID" value="AQT67747"/>
        <property type="gene ID" value="STSP2_00896"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00896"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39774" checksum="5B8FDE36AF232259" modified="2017-06-07" version="1">MKVKDIGREINAIAPLGLALDWDNVGLLVGDENADVKNVLMTIDLTKGVLAEAKRKKVDMIMAYHPVIWDGLKKVTASGEGSIVYDLVRSGINVFSIHTAYDIAMGGVNDALAEIVGIGDAEPIGDFVENPAGDFYKVIVFVPAKSVNKVADAMFKAGAGQIGNYSKCSYRSDGQGTFLPMEGSNPAIGEKGRLEYVDEIKVESIVPGGKLEGVIGAMVKAHPYETPAYDVFREYGIGGKMGLGRMGELEKAGRLDDIVANIKKVTGAKALGMIGPEKKRVRKAAVCAGSCGNIVNTVMKAECDMYLTGELKHHQALAAQEAGLTCICLSHSVSERFALKNLAKELKKRLGDVKIQLSRKDADPFRWKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ63</accession>
    <name>A0A1U9NJ63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00704"/>
    <dbReference type="EnsemblBacteria" id="AQT67556">
        <property type="protein sequence ID" value="AQT67556"/>
        <property type="gene ID" value="STSP2_00704"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00704"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="642" mass="67440" checksum="AEAB729C55EA945E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ71</accession>
    <name>A0A1U9NJ71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67837">
        <property type="protein sequence ID" value="AQT67837"/>
        <property type="gene ID" value="STSP2_00988"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00988"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="189" mass="22184" checksum="755D97889A8D6710" modified="2017-06-07" version="1">MTDRNQQNHDITEASKASAYLRLFVTNQKRIQTYILMLVPNHNDADDIFQEVATVMWSKFDQFKPGTNFAAWGIKIAHNCVRAHYRKQSKQSKILEHDVLDIIANRTGELMDQQTDPQSRYVDALRKCLGKLDTKDRKIVQMRYEQGLPPQQIADRFSRNRMGIYRTLSRIHNVLVQCIRHRLVEENIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA5</accession>
    <name>A0A1U9NJA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ntpB</name>
        <name evidence="4" type="synonym">atpB</name>
        <name evidence="7" type="ORF">STSP2_01166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01166"/>
    <dbReference type="EnsemblBacteria" id="AQT68012">
        <property type="protein sequence ID" value="AQT68012"/>
        <property type="gene ID" value="STSP2_01166"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01166"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="5">
        <location>
            <begin position="131"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="52163" checksum="3197EAC208D484C2" modified="2017-06-07" version="1">MLKEYQTVSEIAGPLMLVEGIEDAKYGEIVDIKIADGSTRHGQVLQVENDKVLVQVFEGTEGIDVSRTTVRFLGKPMELGLSSDILGRVFSGIGRPNDGGPEIIAKKKLNINGNPINPYARDYPNEFIQTGISTIDGLNPLVRGQKLPIFSGSGLPHDEITAQLCRQASVRGKGENFAVVFAAMGITFEAAQFFINDLTETGAIERAVMFINLANDPAIERIATPRMALTAAEYLAFEEDMHVLVVLNDMTNYCDALREISAARKEVPGRRGYPGYLYTDLATLYERAGRIKGRNGSITMVPVLTMPEDDKTHPVPDLTGYITEGQIILGRGLHRKGVTPPVDVLPSLSRLKDKGIGEGKTREDHADLYNQLYAAYARGKEAQELATILGEAALSDEDRKYMQFANQFEARYIGQDWYENRTVEQTLDLGWDLLSMFRDNELKRIDDELIEKYMPQFRKQKDQSSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF8</accession>
    <name>A0A1U9NJF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68059">
        <property type="protein sequence ID" value="AQT68059"/>
        <property type="gene ID" value="STSP2_01214"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01214"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012707960" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="218" mass="22486" checksum="DF48005973F73911" modified="2017-06-07" version="1" precursor="true">MIGKKMLLSAVLLVCAAGLTQAGVTYVDADLTNTTLADGTAVNVTTSGSAATANDQWHVRTGFGNGSDVFASHADSDSPVIVTAINGLVAGETYSVSSYFWVAGDGTPGGNQEWDMSAGLSESGIVGFRYGDATQITDSSYFDSSVMLSEGDRRLFEASLGTAVANSAGQIQVFVSDLPGNDDRTWYDGVGASVVPEPATLSILGLGGLLIARRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN7</accession>
    <name>A0A1U9NJN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67958">
        <property type="protein sequence ID" value="AQT67958"/>
        <property type="gene ID" value="STSP2_01110"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01110"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="30501" checksum="7A9F919A622F2185" modified="2017-06-07" version="1">MLTSVILICNKERHLKRTLANLLETAAGEIEILVYFDGLRQRVIPDKRIRTIFHPQNRGRRVVINEAVIHARGDYIFHIDGHCRMLTDGWDLKMIQAAGLRSTAVASILNLRPDKRHLIRHVMHHPKHLANHFWDEKTPQNTVEDMMTLTGCAWMHHRNLWQNFNERYAGWGYMGIEWSLKNWLCGSGPNPILLCSDIVCEHIGRRHRGNPARTDWLKHNLSPGATLRHINKLYRNNKAPDQQRPLSWLIDKFKPVPGWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN8</accession>
    <name>A0A1U9NJN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">icd</name>
        <name evidence="6" type="ORF">STSP2_01181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01181"/>
    <dbReference type="EnsemblBacteria" id="AQT68027">
        <property type="protein sequence ID" value="AQT68027"/>
        <property type="gene ID" value="STSP2_01181"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01181"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="601"/>
            <end position="602"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="617"/>
            <end position="619"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="756" mass="83122" checksum="741F54E98A9A4A0F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR6</accession>
    <name>A0A1U9NJR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endo-alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.97" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01314"/>
    <dbReference type="EnsemblBacteria" id="AQT68159">
        <property type="protein sequence ID" value="AQT68159"/>
        <property type="gene ID" value="STSP2_01314"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01314"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050110">
        <property type="term" value="F:mucinaminylserine mucinaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012097998" evidence="1">
        <location>
            <begin position="23"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_3" evidence="5">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_101" evidence="2">
        <location>
            <begin position="253"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_101C" evidence="3">
        <location>
            <begin position="523"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="GalBD_like" evidence="4">
        <location>
            <begin position="819"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="983" mass="111033" checksum="9BA25E64B3C81C50" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ7</accession>
    <name>A0A1U9NJZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68263">
        <property type="protein sequence ID" value="AQT68263"/>
        <property type="gene ID" value="STSP2_01419"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01419"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11714" checksum="60ECCC575082A9CF" modified="2017-06-07" version="1">MISKKHLFNAVAFVLLGVFLFFSIPFVFVGNILEEGKEDSDRREKEFLEWRFEQDPDLGEKYRKWKSGELELTTEEYLQMEEEIYGSYDDSNSSEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK23</accession>
    <name>A0A1U9NK23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase YtpA</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ytpA</name>
        <name evidence="3" type="ORF">STSP2_01320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01320"/>
    <dbReference type="EnsemblBacteria" id="AQT68165">
        <property type="protein sequence ID" value="AQT68165"/>
        <property type="gene ID" value="STSP2_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01320"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="105"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="350" mass="39575" checksum="0DD71538EC5CD07B" modified="2017-06-07" version="1">MAGKAIKIRLKYAIWLIGAVVFCCFVFGMVKYAKGHAMDEKRHTIQSQLQPLSQANGEYPQAVKEYFDHYGLGAGEGRGQVEHLFGTFESQGYTLAGHIYRPESYKATVVLMHGYLNHCGQLRYIIEYLLDHGFAVAAYDKPGHGLSSGERAAVESFDVYRKALRDFRDEAAKYLDGPYHVVAFSNGACPVIQDVLGDEGGSFERVVLAAPLVRPVAWKQTKFTYPLYSRFVTSVKRLPRCNTNNKEFIRFNRNEDFLHARAVPLVWVKALFDWNDWVERAKPSDKEVLIVQGDRDGTVDWVHNIAFLESKLPNARVELVEGAKHELFNESLGLREQVFGTVVDYLDGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK60</accession>
    <name>A0A1U9NK60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68128">
        <property type="protein sequence ID" value="AQT68128"/>
        <property type="gene ID" value="STSP2_01283"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01283"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="132" mass="13709" checksum="83CC5F8C8F230EA8" modified="2017-06-07" version="1" precursor="true">MLRRSFGVLLMLGIVAWVVLFADCEAGAAGKGKLQGVLVDEAGEVVAGAEVHLLGPDRIGHFTETVTTDGSGAFSFGSVTAGDHVLAYGPLLEQGRWVEVEVGETSEVEFELEDRGVGGLSGTVSVDGECGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC6</accession>
    <name>A0A1U9NKC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68382">
        <property type="protein sequence ID" value="AQT68382"/>
        <property type="gene ID" value="STSP2_01542"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01542"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012617688" evidence="4">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="501" mass="56018" checksum="EF9267EB7DE43894" modified="2017-06-07" version="1" precursor="true">MRLDRRSFLKLSGFAAAAALSSPSSVFSAVNTKPNLLIIHTDEHNFRTLGCYRKTLSQKQAFVWGKNVAVETPHIDSLAENGTLCTSFYATTPVCSPSRSSFVSGRYPQNTPVVTNNIRMNDDIETFAATLQKHGYKTGYAGKWHLDGFGKPQWGPEREFGFADNRYMFNRGHWKLLEDTPEGPRVAARNNKGRPSYSVANATPENFTTDFLADKAIEFVTANRNEPFCYMVSIPDPHGPNSVRPPYETMYQDLDFQPPETSKKSAEGLPSWGKKARPIGPRGMAKYFGMVKCIDDNVGKMVDHLKKLDLLDNTIVVFTSDHGDLCGEHSRNNKGVPYEASAKIPFVISWPKKIKKGNVINHAMSCVDFLPTVLSLMDVPTSGKEDGRDASGLFTGTDGSYKDIAFIRGTGDRNGTEKGDDKDNWFGVVTSRYKLIYAPEDKPWLFDLKKDPDELVNFYEEPAYKDTRKELAKELIAYAKKHNDPRITVATTKKYLAEAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ3</accession>
    <name>A0A1U9NKJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_01265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68110">
        <property type="protein sequence ID" value="AQT68110"/>
        <property type="gene ID" value="STSP2_01265"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01265"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="691" mass="77548" checksum="A5FD680EB1593E46" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN2</accession>
    <name>A0A1U9NKN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-reducing hydrogenase HoxS subunit beta</fullName>
            <ecNumber evidence="4">1.12.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hoxH</name>
        <name evidence="4" type="ORF">STSP2_01452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01452"/>
    <dbReference type="EnsemblBacteria" id="AQT68294">
        <property type="protein sequence ID" value="AQT68294"/>
        <property type="gene ID" value="STSP2_01452"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01452"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047985">
        <property type="term" value="F:hydrogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="48041" checksum="9A73D6A61CB5EECB" modified="2017-06-07" version="1">MSNVNINVHHMTRVEGHGNIVVNASDGTVEKVQWQVPEAPRFFEAMVRGRKFDDIQTIVSRICGICSISHSLVAIKAVEDALSIDISEQTDMLRLLMHYSEQLQSHVLHVGYLVAPDLFNAPSVVPLVGKAPEAVKTIIGVHRVANQMSELLAGRITHPITLVPGGFSKVPSEKELRQLQDTLKAQVKPLQTICDVVASVAGNLPNFERDTEYVSLKQDKTYTFYHGDIASTEGTVKPVSEWESVANEYVVDQSTAKWAKWNRETYMVGALARYNNNAEYLSPLGKEVAGMFGLKKGCCNPFMNNIAQLAEAAHVVEHSIELIDKILSKGIEDERPNISPKPGRGYAAVEAPRGILFHAYEFDENFECTWGNMCIPTNQNHANIQKDFEKFVPENLESGEDNLRQGLEMLVRAYDPCISCSTHFLDVEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU7</accession>
    <name>A0A1U9NKU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">STSP2_01508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01508"/>
    <dbReference type="EnsemblBacteria" id="AQT68348">
        <property type="protein sequence ID" value="AQT68348"/>
        <property type="gene ID" value="STSP2_01508"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01508"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041397">
        <property type="entry name" value="ThiD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016229">
        <property type="entry name" value="TMP_synthase_cyanobac_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17792">
        <property type="entry name" value="ThiD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000512">
        <property type="entry name" value="TMP_PPase_Cyanobac_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiD2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TMP-TENI" evidence="10">
        <location>
            <begin position="148"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="39191" checksum="BC0F980EAB172512" modified="2017-06-07" version="1">MEKSAYRIIDANLNRGREAARVMEEFCRFYLNSSELSGRAKNLRHRLCGAGNQFDISMLVSARDSGADVGRGLAVSDQLKRTELRDCFTAAVKRISEALRALAEVSQTLKPELTPIFEELRFETYTLEKDAVLAASVKSKVDRIRLYVLVTAAQANTDDELLQLTEACCRGGADCLQLRAKGLSDGRTYRLAEKMVSVCSEHQVVSIINDRPDIALASGADGVHLGQDDMPVSKVRELFNRPMIVGLSTHNADQLEQAIRERPDYVGLGPVFETRTKHIEKLAGLEYVEHAVSRLHDTGIGHVAIGGINAVNADDVISAGASAVAVCSAVTGSNDPAAACDELNNILSKAGPENDQLKAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL53</accession>
    <name>A0A1U9NL53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68527">
        <property type="protein sequence ID" value="AQT68527"/>
        <property type="gene ID" value="STSP2_01692"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01692"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="37915" checksum="A566985A0F84ED8A" modified="2017-06-07" version="1">MSFGYKNKGFSLLEVMIAAGILAVGFMLIVAMWPAAIKLTAMSTERTIGAVAADEAAVKMPLYGVANVDQETVDNANIRYQAVAASDKYAYIVPNDVDGTLVTTGVNDVYVDLVDVTGWPWDPLAKDGEGNDIWDFSNETAYPSTETFDGPKHYHWSALCKYNDDVDNFAVTDRTFDAVVFVCRLGIENKVYPYVNVSGNLITSPLPRPMRVFVDYKIQGGLITGFEVSWLTSSDLSYDKKENLKLAKFMTENVSVVDDRAGRLLAISNIEITESADDKSDAVKGDVLTAILAKDFSMTYPSWVDTPGEVEAYLKDWPVWFIPHAIGGGKSPCVGVYHKNMLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL55</accession>
    <name>A0A1U9NL55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yitJ_2</name>
        <name evidence="6" type="ORF">STSP2_01841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01841"/>
    <dbReference type="EnsemblBacteria" id="AQT68672">
        <property type="protein sequence ID" value="AQT68672"/>
        <property type="gene ID" value="STSP2_01841"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01841"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="31154" checksum="A203027EA85C18E6" modified="2017-06-07" version="1">MSERKLLERINEGVFFIDGAMGTELMARGAKMGECNDHLNVTEEGSAIVKAVHASYLAAGSDAVITNTFGANAITLKRHGYADLAGKISEAGAKIAREAADAAGGDRFVFGDIGPCGDFLEPLGMLKRDELLAAFREQAKGLADGGADAIIIETMTAVEEIEVAVEAAKSVCDLPVFASLAYDPAGEEYRTMMGIDAAAAVDRLGNTGVSGIGFNCGTLDMEGYVGLAKAYADAIGDKGLVLLAEPNAGKPELVEDKAIYSLSPDDFAAAGEKIKAVGAGIMGGCCGTSPAHIEALVKKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL72</accession>
    <name>A0A1U9NL72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01412"/>
    <dbReference type="EnsemblBacteria" id="AQT68256">
        <property type="protein sequence ID" value="AQT68256"/>
        <property type="gene ID" value="STSP2_01412"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01412"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120720" description="Rhodanese domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="409" mass="46461" checksum="E64B68E143082379" modified="2017-06-07" version="1" precursor="true">MRKHSILLCSSLLMLFSCAKCLASWDSVALKSCDFSEVGLSRASVEHTCRNIVETSYTGLDLQSLKKRYPDSKLDCYRLKQGTYFLVWALEFDDRGRDITVWAMVDDGKIAINKQAILGGTCQPYVDGDMLFRKKDTSFYRVFLRYHDALYSGSSGGRSYAWEVDMNNLKVMALCAVSWPEVSSRNWPEAPVLDKDTFHLTIKMPTRRFLYGIWGTDWVDINYVGAGVEAYRKSSIYVEMVIPPNLIMNQSIDQDSLIEKNYSQLVYNNPGFAEIGSEELSYLLENYSKRVKLVDTRLADEYEVSKIQDSVLYKDSEGQELISEGNKVLIFYSDIGYRSSVVVKHLLAHVREKKKGDDINVYNLRGGILAWINSGGSVVDSANEKTNKISVDADYRICLPEGYIFVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL74</accession>
    <name>A0A1U9NL74_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lon2</name>
        <name evidence="5" type="synonym">lon</name>
        <name evidence="13" type="ORF">STSP2_01863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01863"/>
    <dbReference type="EnsemblBacteria" id="AQT68692">
        <property type="protein sequence ID" value="AQT68692"/>
        <property type="gene ID" value="STSP2_01863"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01863"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="615"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="796" mass="87988" checksum="BAEBE1FB70327C8C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC0</accession>
    <name>A0A1U9NLC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serA</name>
        <name evidence="6" type="ORF">STSP2_01699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01699"/>
    <dbReference type="EnsemblBacteria" id="AQT68534">
        <property type="protein sequence ID" value="AQT68534"/>
        <property type="gene ID" value="STSP2_01699"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01699"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="4"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="319" mass="34199" checksum="BA8E695A06AC0376" modified="2017-06-07" version="1">MVKILIADKLAQEGIDLLESIDGIKPVVKTGMSEDELCECISEYDGIIVRSATKVTARVLECADKLRGVARAGVGVDNIDIPAATNNGVLVMNTPGGNTIAAAEQTMTLMLALSRNTVPACNSLKAGAWDRKKYMGNQLYQKTLGVIGLGRIGMAVVKMSTGFDMKVLGYDPIAVPNEAKELGVQVVDDLDNIFKEADYISVHVPRNEHTTDMIAKDQFEMMKPTARVVNCARGGIINENDLYDALEAGKIAGAALDVFEQEPPENKRFQDIDNCLVTPHLGASAAEAQVQVAVEAAQILADALTGGEIKNALNQVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH4</accession>
    <name>A0A1U9NLH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68759">
        <property type="protein sequence ID" value="AQT68759"/>
        <property type="gene ID" value="STSP2_01931"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01931"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="276" mass="31226" checksum="C30800A39732FB24" modified="2017-06-07" version="1">MKKKGFTLIELLVVISIIALLLAIMMPALGKVKELAKSTVCGSNAKTMVTAWRLYAEDNDGQMCSSWTYDTRHGWGNTWDWVWAPYELDGSGSADEFDATEKERREGIKRGAIYSYCSDADAFHCPSDKRTNNQQGNAKFRTYSIPDSLGGPEGYYPWRVFTKISQVKQPSRKYAIVEENDSRGYNMNSWILFPDESSPNGFSTTAWCDPYLSAFHNDSSTFAYVDGHVDSRKWSRETIEYLDTPQSEFNNAWGSKVPSTDAGKDDLIWLTNGWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH8</accession>
    <name>A0A1U9NLH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor protein FixL</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fixL</name>
        <name evidence="5" type="ORF">STSP2_01855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68685">
        <property type="protein sequence ID" value="AQT68685"/>
        <property type="gene ID" value="STSP2_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01855"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43661" checksum="732F88775CE805A9" modified="2017-06-07" version="1">MEQCADTASGLLDNLCACIYSAKVSDEVQFEFISRGSERLTGLGAQSVMSSAGGWLSVVHPDDLEEVESCYRRYAENGAGEEIEYRVMHADGSVRYVKDVSAVRNEGREVYVDGIVEDMTAIRRAEADLERTQMLQRIGGLAAGIAHEINTPIQFIGDNLTFLSDSFGSILDLIEKQKEVCDAVSGDIDDESAAVLESLEEAADLDFLKEELPQAIDQSRDGVKRVSKIVAAMRDFSHLDERRMARADINKALESCLVMVRNEVKYVADVRTEMDRALPGIVCCIDELNQVFMNLIINAAQSIEQKIKGTHNRGLITVGTLEEQDSIVVFVSDTGVGVSEEVSGRMFEPFFTTKPRGKGTGQGLAMAKTIVERKHKGKIEFETEPGQGATFKVCLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI8</accession>
    <name>A0A1U9NLI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01867"/>
    <dbReference type="EnsemblBacteria" id="AQT68695">
        <property type="protein sequence ID" value="AQT68695"/>
        <property type="gene ID" value="STSP2_01867"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01867"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="352" mass="40682" checksum="5FF740EBBEC7CE9A" modified="2017-06-07" version="1">MNDFLQKRCFRWIELAALLPGGKMVRGVLAGRDNLEAINNWRKKYGNTNIFTTVQLFEKDDLNSAFIAPVFFDIDSPDDLEKARSDTLKLCELTTDRLEIGTDMLEIYFSGSKGFHVTIPPEVFDAFPSRYIMELYNKMALKACSYGIETIDRTVYTHRRLWRIPNSINSKSGLYKIPLLHKELLHLSADQIAKLAEHPRSEDSFVTAKYSNTAGLWYRKAIRAVAKAACKTTATTQDNSDFKQGWRIPPCIENIQSTTLPDGIRHQTYLALARFYRWINMHPEQIIKRIRTIDSRQPIDDPDFIKRIAFWAHQHPGFAGCTHPVMQKYCSKESCFYYRIKAGRKHGSKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL5</accession>
    <name>A0A1U9NLL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01624"/>
    <dbReference type="EnsemblBacteria" id="AQT68460">
        <property type="protein sequence ID" value="AQT68460"/>
        <property type="gene ID" value="STSP2_01624"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01624"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="470" mass="51085" checksum="8BEEAAEB4EBACC20" modified="2017-06-07" version="1">MPVCDNFLGRLRLKAAALIVLRDISRVTIWWGFVLGFVILVLRALAFVPYQAGFWLLGSGVLLWGAAAFISFRKVPSLESVRALVDKHSGCGGLLIASDQMELGKWADSMPEPKLVLFKWRCRREMVLLFSAVVFLGACLAVPQRYINVSTVKRLNVDADVDRMSKQIDTLEEEDVIADSEAAELRKKLKQIRDEARGDDPVKTWAALDHMQKSLKNAAQEQAMADVSNTEKAAKAEALAKAMEENSGQMGEKLTDEAAAELKETIEKMAANNSALKNAMSDSLKEALASGTAKEGGQLSKEQLEQLRKALQGAQNQMAGRLGKLQDAKLIDGKMVKKAKEGTQIDPAALAAFLAENADGMGVSAAMKAYMPGKGGVSFGRGDAAMTWKDKSSETGTKFEEQILPPGSVEAMKDSKMVGVSVSDPSDTEEVEKNVGGFIDAQGGTGQATKRKILPRHKKAVQKYFEREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT1</accession>
    <name>A0A1U9NLT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophan tryptophylquinone biosynthesis enzyme MauG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01610"/>
    <dbReference type="EnsemblBacteria" id="AQT68446">
        <property type="protein sequence ID" value="AQT68446"/>
        <property type="gene ID" value="STSP2_01610"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01610"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346506" evidence="5">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="364"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="471" mass="53938" checksum="617AF77BE09E518D" modified="2017-06-07" version="1" precursor="true">MRKSFFAVMTLCVLVCAVVFAAEHEGEKMTAEDLPRQTYMPVVLEQDFEEIMASDKAEKDEVMQRQMRLLRRRYDLSDMPAEGVMMSGGRKAVQKGVRVKLPEGVGSWQELAEMSPEEIKEKGLWPRGFLPLPHAKHSTGGQVFPQDQIDEIMRLEDRSLLRFDVEFDLPDHFTPEFPPPIFLTTRPDLGDVSQGKVLSIKNYYDIMLGKLTPVQMEGLRLLLTPFPQQQFNATYDRKVEEPSLGVSCLDCHVNGHTNATFHLNPDTRPQEARFRIDTVSLRGMYNQQIFGSKRSLRSVEDFTEFEQRTAYFDGDHVTAAKKGVHLPDRASQVAMMAQMQIIFDFPPSPKLNRFGRLDPEKATEEEMFGQEVFFGKGKCAECHMPPAYEDGKMHDLKVERFYEPQMINGQFITAEGPIKTFALRGIKDSPPYMHDGRCLTLEDTVEFFNLVTDLKLTEKEKKALVAFMRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT3</accession>
    <name>A0A1U9NLT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">exbB_2</name>
        <name evidence="11" type="ORF">STSP2_01968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01968"/>
    <dbReference type="EnsemblBacteria" id="AQT68795">
        <property type="protein sequence ID" value="AQT68795"/>
        <property type="gene ID" value="STSP2_01968"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01968"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017270">
        <property type="entry name" value="MotA/TolQ/ExbB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037714">
        <property type="entry name" value="TolR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013296079" evidence="9">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="356"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="503" mass="55021" checksum="FF523686BACA141E" modified="2017-06-07" version="1">MKITKIISIILLFAAMQVFGDLTDGDEASVTELQNLADPLVSSEDEPQSEFGKASQSAKRKMEESVAELAELRKQIADKTIPLTRQLNDLEEELSEVRREYQETSRLLDTRTLDLSNLRNEIKARKEEASYISNLMGQFAVNFEARLHIAEIQRYKDTLEHAKTSPENSNLSKREVFKAQSDLIQESLEGFEQAIGGKTFHGKAVDSTGLVNDGKFVLIGPAALFKSEDGQKVGTVEQRFGSLEPTIIPFANEQNKAAASELISNESGRLPLDPTLGNAHVVESTNQTLVEHVQKGGPVMIPILGMAGLAMLVALYKWIALSLIPKPGKRKINKLLDAVESRDPAKAEKAVQSIKGPVGKMLRRGVEHIKEPAELIEELMYETVLDTKLKLERFLPFVAISAAAAPLLGLLGTVTGIINTFKLITVFGSGDVKTLSGGISEALITTEFGLIVAIPSLLLHAFLSRKAKRFANDMEKAAVAFVNQVSKTPVKKNDLPEKVKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV8</accession>
    <name>A0A1U9NLV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68889">
        <property type="protein sequence ID" value="AQT68889"/>
        <property type="gene ID" value="STSP2_02066"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02066"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="33" mass="3663" checksum="AB06F02E30016230" modified="2017-06-07" version="1">MLEYMQETGDMLEVCMVSGYNQKVTGSSILFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV9</accession>
    <name>A0A1U9NLV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcosine/dimethylglycine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.157" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68815">
        <property type="protein sequence ID" value="AQT68815"/>
        <property type="gene ID" value="STSP2_01991"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01991"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052729">
        <property type="term" value="F:dimethylglycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052730">
        <property type="term" value="F:sarcosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31467" checksum="B3F6CAF66DBB93F2" modified="2017-06-07" version="1">MSSSYSKTVSTARDYYNSSDADKFYFNFWGGEDIHIGFYETPDDSISQASRKTVKRMAAKCENLNENSRVLDLGAGFGGAARYLAKTYGCHVTALNLSEVENERDRQMNKEQGLDHLIDVVDGAFESLPFEDGSFDVIWSQDAILHSDQRDAVIKEAARVLKPGGEMVFTDPMQSDDCPENVLQPIYDRIHLESLGSPSKYKKMAKDAGLEVEEFDELTDHLPHHYHSVLKKIENSDRPKKLGISDEYIKNMKKGLQHWVDGGKQGYLSWGIFHLKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM47</accession>
    <name>A0A1U9NM47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transport protein TonB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">STSP2_01971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01971"/>
    <dbReference type="EnsemblBacteria" id="AQT68798">
        <property type="protein sequence ID" value="AQT68798"/>
        <property type="gene ID" value="STSP2_01971"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01971"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="224" mass="25151" checksum="299E15015726E293" modified="2017-06-07" version="1">MRNIKRKKFWLIRELSHRIFVMAGAVAITLAFFLVLPLMQTLSKPPKQDMVVRSVDTGKLEAPDPPPEPEPEEEEPEPEKEPPKLEQNNAPLDLSQLEVALNPGFGDGWAAGDFGVSLNTFASENKDVDALFSIADLDQKPRVLYQPGPTMNAQMRKNAPGKVYVIFIVDKQGRVASPRVQKSTNPVFEKAAISTIKRWKFEPGKRNGKAVRFRMRVPFVFPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM92</accession>
    <name>A0A1U9NM92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial membrane flanked domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68710">
        <property type="protein sequence ID" value="AQT68710"/>
        <property type="gene ID" value="STSP2_01882"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01882"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23664" checksum="EEDA5F5E8340DAEC" modified="2017-06-07" version="1">MQKTISKSETNKYSNDVISSTHKQAYRWMIPKRFKKFLRDDEVILYACRPTLRDLGLRWVAAGFYYLVLGSIILNMLLFHQPADLQKVIFIAFIVGFLTLAAAIFLRWRNRFYMVTEVTTFASKGILHRTIDMIPNSGIQMVSIRTGFVSGLMGLNSVIISISQQGGNNLLTSTLGTCRGSITLRSVPDIDRLTAIYDGLLFRKNSTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA0</accession>
    <name>A0A1U9NMA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01804"/>
    <dbReference type="EnsemblBacteria" id="AQT68636">
        <property type="protein sequence ID" value="AQT68636"/>
        <property type="gene ID" value="STSP2_01804"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01804"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="31189" checksum="FA123E35AFF5B80A" modified="2017-06-07" version="1">MKFDNSKIDGIIRIEKLIKKFDSRVVLDGISLSCEEGKTTVIIGPSGCGKTVLMKHMIALERPTEGQVYFKEQRIDEMHEKKLARLRLNFGFLFQGGALFDSLNVYENIIFPLRQHTKIKDWDAVDELVKQKLALVGMDGYQNHMPANLSGGQQKRVALARAIALNPQVILYDEPTTGLDPIRSDIINELILKLQQELTVTSVVVTHDMNSAYKIADRIIMLHNGKIVADGDAEHIRNHPNDIVQQFINGRVGEAELAALRHGGTKFTTQFKPEDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH0</accession>
    <name>A0A1U9NMH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinoxylan arabinofuranohydrolase</fullName>
            <ecNumber evidence="6">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xynD</name>
        <name evidence="6" type="ORF">STSP2_02296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02296"/>
    <dbReference type="EnsemblBacteria" id="AQT69109">
        <property type="protein sequence ID" value="AQT69109"/>
        <property type="gene ID" value="STSP2_02296"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02296"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112422" checksum="21772F6C90E304A5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH9</accession>
    <name>A0A1U9NMH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Levanase</fullName>
            <ecNumber evidence="8">3.2.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sacC</name>
        <name evidence="8" type="ORF">STSP2_02115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.80" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68938">
        <property type="protein sequence ID" value="AQT68938"/>
        <property type="gene ID" value="STSP2_02115"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02115"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051669">
        <property type="term" value="F:fructan beta-fructosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188776" evidence="5">
        <location>
            <begin position="20"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="202"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="494"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="644" mass="72420" checksum="DAFDFE83C5B5D205" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ4</accession>
    <name>A0A1U9NMJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68726">
        <property type="protein sequence ID" value="AQT68726"/>
        <property type="gene ID" value="STSP2_01898"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01898"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10413" checksum="77CDC64900C3B689" modified="2017-06-07" version="1">MNLTLRKFLVVLLIAAVLVLGNIVVIAHWLDEVGVSPLAERISDDFLTPTAVTIISALLILLVGPSRHAGSTMSCPVCRSRVRRADKYCPECGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN01</accession>
    <name>A0A1U9NN01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02480"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="23620" checksum="0B626D3DEC6353F1" modified="2017-06-07" version="1">MWFQVGFLFMAKNPERRIEYEGLGEVLFAKHRRARRLSISVRPFKGVRVTVPWRVSFAAAVRFFEEHRSWAAKSCAKMARVEAEQRAAVAELPVIDRAEARRVLVGRLAKLAGMYRFSYNRVFVRNQKTRWGSCSGKNNINLNVNLVRLRQELIDYVLLHELVHTRVKNHSARFWRELDKYVGDAKYLDRCLRDEGIPRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN32</accession>
    <name>A0A1U9NN32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulose kinase</fullName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xylB</name>
        <name evidence="3" type="ORF">STSP2_02325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02325"/>
    <dbReference type="EnsemblBacteria" id="AQT69138">
        <property type="protein sequence ID" value="AQT69138"/>
        <property type="gene ID" value="STSP2_02325"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02325"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="259"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="53777" checksum="CDACAC64D886153E" modified="2017-06-07" version="1">MYLLGYDCGTSSIKVTLLDAGSGVPVASATAPSNEMRIRSPKPGYAEQPPNSWWENLKIATTEILSISQVDPSQIRAIGITYQMHGLVLVDKQLEPLRDSIIWCDSRAVEIGSNAFEQLGPDTCLNDLLNSPGNFTASKLKWVKDNEPDIYRKVHKAMLPGDYIAMKLTGQVFTTESGLSEMILWNFRKNCLAQSVLDHYEIDKDILPEAIPTFSDQGELTSSAAQELGLAAGTKVCYRAGDQPNNALSLNVLGPGEIAATAGTSGVVYGVTDVPSHDPQSRVNSFVHVTHKPDSPRYGVLLCVNGTGIQNNWLKNNVAPDLDYAQMNEQAADIPPGSEGLVTIPFGNGAERILANTCPGGSITGIDFNVHSRPHLFRSAQEGIAFALNYGLSIMKNMNVKPQKIRAGNANMFLSPVFRQAFCNITGTTVELYNTDGSQGAARAAGIGAGIYADFYEAFEGLKCTATIEPDQALKQPYKDAYEKWIEILNRHIEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN70</accession>
    <name>A0A1U9NN70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02436"/>
    <dbReference type="EnsemblBacteria" id="AQT69247">
        <property type="protein sequence ID" value="AQT69247"/>
        <property type="gene ID" value="STSP2_02436"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02436"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="42856" checksum="86C0451FB8985971" modified="2017-06-07" version="1" precursor="true">MAAHVKKYILVLVVVSAFLCVLITARSYQSKYSWAYGEVNLAGWRTNVDKSVIALGELVQVGIGKESETALRDPWFETAGSASFWVEDTEPVLVTSIGDTAKAYPLQILVWHQIVNDEINGVNIAVTYCPLCSTAVVYGRDLNDSVYDFYVSGFVRYGNFVMYDDSTETLWQQYTGQGLVGDLAGEYLVRVPSQIITFERFRSAYPDGEVLSQVTGVTRDYGLNPYWSGYDYYYGSYVGPGLFYGQYGYAGRILNVSTERTSKAYSYLLTRNEYVLNDIVAGQPVVIFNNGSTDYGLMDATGVFDRSFDGRVLEFKYEDGDFVDHQTGSRWNIMGHCVEGQYKGRRLDPLNYTDTLEETLETFEPGVEIYQPDGEIEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN72</accession>
    <name>A0A1U9NN72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69285">
        <property type="protein sequence ID" value="AQT69285"/>
        <property type="gene ID" value="STSP2_02474"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02474"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4219" checksum="8C8C4C16080588B7" modified="2017-06-07" version="1">MDKYIGFDIDSKKTVACVVQKGKKIVSRPLRRILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="10" type="ORF">STSP2_02651</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <taxon>Anaerohalosphaera</taxon>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AQT69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Exosortase"/>
    </dbReference>
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        <property type="entry name" value="Hexapep"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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        <property type="entry name" value="Trimer_LpxA-like_sf"/>
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        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="632" mass="70317" checksum="62D90794DAC40E43" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH3</accession>
    <name>A0A1U9NNH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrK_1</name>
        <name evidence="7" type="ORF">STSP2_02251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT69066">
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        <property type="gene ID" value="STSP2_02251"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
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        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33688" checksum="F7666B13A8890BDC" modified="2017-06-07" version="1">MGNGCNHKHTIFTAHVLESIEIGPLYHRTTFQLDEVGSKAFADAVPGQFAELDLTAVSLPPLEKIPPKLVDACKRNIILRRPFSFADIRKDNPGAIEIDILFCVLGPATVRMTSLRPGDSVSVIGPLGNGFSVPEGTKNALLVAGGMGAPPLQHLGFYLRENFPDMNVVAFAGAKSKEDLPYQLLEAPERDTELAEFSRCDVPAHIATDDGSIGMKGFVTQALENWIRTNDPKSGSTVIYTCGPEPMLAQVAKIAISHDLPCQVSMERRMACGIGLCQSCAIEVRTPASEETVYKLCCKDGPIFDARELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI4</accession>
    <name>A0A1U9NNI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02672"/>
    <dbReference type="EnsemblBacteria" id="AQT69481">
        <property type="protein sequence ID" value="AQT69481"/>
        <property type="gene ID" value="STSP2_02672"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02672"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
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        <property type="entry name" value="YHS_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="2">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12571" checksum="04EABDC5672DFB9A" modified="2017-06-07" version="1" precursor="true">MRNLAIVICVLVVGSFVVIGLSGCGENGGESAPVENEQMDHENHEGHDHEAMEEESEAGSEETAQKICPIMGNEIDKGISTEYKGKTVYFCCPGCIDTFEENPEKYVDELPQFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL6</accession>
    <name>A0A1U9NNL6_9BACT</name>
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        <submittedName>
            <fullName evidence="4">PA14 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69425">
        <property type="protein sequence ID" value="AQT69425"/>
        <property type="gene ID" value="STSP2_02615"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02615"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012821160" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1471" mass="160779" checksum="6C5176417C791619" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP4</accession>
    <name>A0A1U9NNP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase YycG</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yycG_2</name>
        <name evidence="4" type="ORF">STSP2_02733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69541">
        <property type="protein sequence ID" value="AQT69541"/>
        <property type="gene ID" value="STSP2_02733"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02733"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="200"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="550" mass="60876" checksum="EF91127E5C6A5F68" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ7</accession>
    <name>A0A1U9NNQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02439"/>
    <dbReference type="EnsemblBacteria" id="AQT69250">
        <property type="protein sequence ID" value="AQT69250"/>
        <property type="gene ID" value="STSP2_02439"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02439"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="443" mass="49013" checksum="3E0468E7A514F4EE" modified="2017-06-07" version="1">MKMFRDLEAKLDSFEKSERVNAINALIQGTGDAGIKMPEPKPTVNLHCHTFFSYNCYDYSPSKLAWLARQKGLTAAGIVDFDVLDGVDEFHRACFMLGLKGFAGLETRVFVPEFSDKVINSPGEPGIAYHMGVGFPTGDVDTECAVFLDKLRTIARERNESLIGRVNDYLSPVTLDYEADVLSLTPNGNATERHICLAYAKKAEEVFGNGEELADFWAEKLQMDRKELDLPDGVGLQGAIRAKTMKKGGVGYVQPDGGSYPTLRETNRFILDAGGIPTMTWLNGLTDGEQLIEEMLDVYMAAGVAAINIIPDRNFTPGVVDEKLEKLHEVIGLAKKKGLPVFVGTEMNSPGQKFCDDFESDELAPFEDTFMQGAYIGYAHSVLQRYLGVGYLSEWADENFDSVFDKNAFFAEVGRKLPVERQPRLTDLSGNDFEPGDIMNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS5</accession>
    <name>A0A1U9NNS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69447">
        <property type="protein sequence ID" value="AQT69447"/>
        <property type="gene ID" value="STSP2_02637"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02637"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3485" evidence="1">
        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="24480" checksum="9026952AFE10257B" modified="2017-06-07" version="1">MSTIENRNLILLSLGTLLMVTGGSIYRQTHTGKHLPGTTKPKDTLNGMIPWDIGDWHGEEIDLIDFQDPDFFADTAFLRRYRNPEKNRYADLYIAETKIPAAMLGHRPDVCYVAGGWVLDETKSLNVETTTGTAIPCSLSVFHNPSDLQRKVVLNFYIYEGDIYRNETAFRGLKWRLDSNRTKSDASLAQIQISSQYESVALEYLQLMGDVLIDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ9</accession>
    <name>A0A1U9NNZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69641">
        <property type="protein sequence ID" value="AQT69641"/>
        <property type="gene ID" value="STSP2_02835"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02835"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32376" checksum="77EB5211B1CE5678" modified="2017-06-07" version="1">MIMKNSYRQNSSKHHAGFSMLEVVTAVVAASIIMIATLTAFNRIRSATHTMHKAIGSRDKVSDVLQLITEDLDTLAMPGSDTRLSVRNHTFRGITRARLTIENRIYDSSNKAHTFESVTWQTDYDPDSQSFILYRAHGGMALEDPILDTVGTEESPSQEDLQDSDLEPFIPVATGLTYFEILGMANGRELQTWASSKLPTAVKIVLSFADPVEVAPGEFEILEEDLVTRVIAVDRTRKIKYSFMKEEYELPDPNDFSYEEDQEDLDEDTEGEMTDQSADELEFEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP03</accession>
    <name>A0A1U9NP03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component PulL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69643">
        <property type="protein sequence ID" value="AQT69643"/>
        <property type="gene ID" value="STSP2_02837"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02837"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="484" mass="53167" checksum="C53EDB2199F1EF63" modified="2017-06-07" version="1">MEHKNSLGLYISNDSATAVVLAGHTSGASLVGAVSVKLTDPENDDQPKSYEQLAVELSKALSQKNLKFDSAAAAVDCSLYTQHTIRSEFKERRQIASTISFDAEEAVATDATRLAVTFNIVAADAIGSYVSTFTAGREEMTDLLKSLLSKSIDPTAIEPDVASLVRFFERYIDDQTPDNSLYVMATETACYLIKPSTEYEASTRSFIVTPTQNKTSVLKRELPLTIASLNEDVDITKLYLIDTTESIDTESLADVTTAQIEPVDLLQLTGASGDLAYDIPEIGHIAFAWGAALGDLTFCRRTDFREDFMPYQGRQKAIRTCLRTMSVCATVILLAIGAHFHLKLKTAEYQADGIQAKLIEQYKGAMHGKPPAGKIPIVSKLKSERNKLKNQKSGLALGDENSMPAKLTFILSALNDENLKNADLTIDQISINENNMTIRGNTPSKIHTLKLYTAIDENENLKRVTDRSSRSGNRDVFTVTLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP05</accession>
    <name>A0A1U9NP05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-inositol 3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshA_3</name>
        <name evidence="3" type="ORF">STSP2_02823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69629">
        <property type="protein sequence ID" value="AQT69629"/>
        <property type="gene ID" value="STSP2_02823"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02823"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="378" mass="42078" checksum="9C5DD647523FB554" modified="2017-06-07" version="1">MIKLLMINYEFPPIGGGGANANLQLLKQFAGNPELQIDLLTSAPEPGVFTEEFAPNVKVTRVGVHKKSLQCWRKIEVIEWLMKADKVCRQMVRSNDYDLAHAFFAFPSGWLCYRNRGKLPYLVSLRGSDVPGLNPRFKLDYKLLAPLFRRIWKNSKLLVACSNGLKERAKNFMPEADYTVICNGVDTDLFKPGRNCSDGTFNLITVGRLSATKRLDLLVEAVGILRDKKHDVRLSVVGTGQLENELREDVAEKGLEHAIELSGHLKPKEVCRLYRKSDAYISGTMSEGMSNSMLEAMACGLPLISTDCEGLEELLDGNGIAVADANPGALADAVERLIAQPEMLKSMSEISRERALRFSWQDSAAQYMSLYNEILAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP65</accession>
    <name>A0A1U9NP65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69306">
        <property type="protein sequence ID" value="AQT69306"/>
        <property type="gene ID" value="STSP2_02495"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02495"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="407" mass="46296" checksum="F78C5414C09DCD40" modified="2017-06-07" version="1">MEYTVDSGTESESASCIYGNYVDEALLMADANGDRTHAYIHNNLYSPVAMIDWTDGTIAERCEYSVYGTATVRLPGPDGSYYTADDITQDAPKTANPYLYTGRRLDILEGGSLKLQYSRHRYYDPQTGRFLQKDPLGIAPFGLILGNSFDPVGQYDGGLLAYSYGRLIPTIAVDFLGLKDYAIGNGPRPDINWDDNYEYDASAKPTLKDYLYWFIFRELLKTLEATGFMPDAARAYRHYRGASGDDLHVKYNKAIKEDAKIRRSFESEIAGAQADIERLHDGETKEFWVYSQEERGTGHPETQNWQKALGGHCIWGEGPVKYDSATCEYSFHISIEMEDWYNFNPAQNDIATGLPDEINGRFQRLGWAKAFFSRGKVERTVKWKRGKASTTTEIDGEPRRRSRRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP93</accession>
    <name>A0A1U9NP93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ORF">STSP2_02937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02937"/>
    <dbReference type="EnsemblBacteria" id="AQT69741">
        <property type="protein sequence ID" value="AQT69741"/>
        <property type="gene ID" value="STSP2_02937"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02937"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="126"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50822" checksum="265D3741F9C3CE61" modified="2017-06-07" version="1">MAKKQKKIYSVSEVNAIVKMVLEANLPPRLTISAEISGWKHHRSGHCYFSLKDPGGIIPCVMWRSNFAKTKFRPEDGMAVLATGYVDVYERGGKYQFYAERMEPAGVGQLQVAFEQMVKRLTEEGLFADEHKKPIPKYPMRIGVMTSESGAAVRDISDSIYNRWPCAELTLFPVPVQGEGAAAKIADAIREVNRRNDKLNLDVLIIGRGGGSLEDLWQFNEEAVARAIYDSQVPIISAVGHEVDVTIADLVADARASTPTKAGVIAVPDVNEVMDALSTTQKRLAMSLRSRLDLARQQLHAIQASVVFRRADWTVNQSRQLLDETTTDLVQSMQGRLAGHRAELDLSRDKIRQIEPHRLLGRKQLHLESLSSSLRSSTKEVIAKRQLQMTAIENKLSALDPKAVLKRGYSMTVNDKTGKVVTNSADAEIGDRIVTELASREKLTSTVKTKQETSRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA0</accession>
    <name>A0A1U9NPA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA</name>
        <name evidence="5" type="ORF">STSP2_02859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02859"/>
    <dbReference type="EnsemblBacteria" id="AQT69665">
        <property type="protein sequence ID" value="AQT69665"/>
        <property type="gene ID" value="STSP2_02859"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02859"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="309" mass="35000" checksum="7164023605FC5E0B" modified="2017-06-07" version="1">MGDKVIVARDVNKSYGAVRAVSDLSFEVEEAKCFGLLGPNGAGKTTMMKMVYGKSVGDKNGVGELKIFGYEPPKEELQIKYLSGVVPQEDNLDEELNIRQNLLVYSKFYDMPEDKAKERIAELLEFMELTARSKARIRELSGGMKRRLVIARALLNRPRLLILDEPTTGLDPQVRHVIWDKIRQLKKQGTTVLLTTHYMEEAFQLCDRLLIMHRGVKVMEGVPRSLLRDNVERYVLELFEHPPVGDLLGKEVLDRVRVEVAGDVTRLFSEDMDLLKTVADEIGGHYYMREANLEDVFLKATGSTLGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB1</accession>
    <name>A0A1U9NPB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity zinc uptake system membrane protein ZnuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">znuB</name>
        <name evidence="8" type="ORF">STSP2_02950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02950"/>
    <dbReference type="EnsemblBacteria" id="AQT69753">
        <property type="protein sequence ID" value="AQT69753"/>
        <property type="gene ID" value="STSP2_02950"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02950"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="27867" checksum="4DC33FC037B1ABC3" modified="2017-06-07" version="1">MDIFFLPVIIAGIMAGASIGLLGVYIVGIRMPFIGTCISHAAMVGAIYAALIDLNSTLGAVIASVTAAASLSLIKPYRTRLDSNVGLSAVFSLMLGLTFLGVGLEQGSRNEMLSLLWGNVLFSDWTTVTITSAATALLLIFALAFNKELKALLFSRSIAAASGIHEQFVYFLLLCITGITLAVNIKAVGGLLIFSLISNPAGAAYQLFTGFRAIILASITAGVLSTLVGFTLSYTLDLPTGACIVLTSTSLLGLALLLRKILKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC7</accession>
    <name>A0A1U9NPC7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_tran_28_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02650"/>
    <dbReference type="EnsemblBacteria" id="AQT69460">
        <property type="protein sequence ID" value="AQT69460"/>
        <property type="gene ID" value="STSP2_02650"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02650"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18250" checksum="0C3008201899D478" modified="2017-06-07" version="1">MIFLTVGAQFGFDRLVKAVDMCVEKGVIKDDLFAQVGNGRYIPRNFPFKPLLNSKQYGEQFANASAVIGHAGMGTIITALKMNKPLLAMPRLKEFGEVVNDHQIAICRRFAAEGLLLPAYSETELPERVVNLAEFVPLKREPQPEKVFDRIREFLKELDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI0</accession>
    <name>A0A1U9NPI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-W factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigW_5</name>
        <name evidence="4" type="ORF">STSP2_02942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69745">
        <property type="protein sequence ID" value="AQT69745"/>
        <property type="gene ID" value="STSP2_02942"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02942"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="23696" checksum="FDAAF6D1FC5B6570" modified="2017-06-07" version="1">MQTQPVNKTDKDTITIDDLTLVRKCKAGDTVAMKHLILRYQDRIYNLTHKICQNPEDAAELTQETFVKVIQSIRKFKENSSFYTWLFRIAVNLTINHCRRKFRISTRSLDAFSEGDEGKARQLKHYLADSSAADPALVAQDRESVEILNASIAQLDEKQRTILVLRDIEGMPYAKIADTLEVEIGTVKSRISRARKSLREILDSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ5</accession>
    <name>A0A1U9NPJ5_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_02721</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="85"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10849" checksum="8E4986B4FDD24669" modified="2017-06-07" version="1">MSDPTKWFVQNSPELGQLFADFYEGCKEKGALDKKTKELLMASLACVFRCPHCVEEHIKGALDAGASKQEVTEALLIAAVEGAGTQLAWKKETFMKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV2</accession>
    <name>A0A1U9NPV2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">STSP2_03153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Sedimentisphaerales</taxon>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69953">
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        <source>
            <dbReference type="EMBL" id="AQT69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7674" checksum="F3AB9088455F1FE4" modified="2017-06-07" version="1">MAVSYQAIIDKIDQAILDGVDGPVKFSLSGRSFEYNSLDELLNARAKYARLNAGKKRPGGVRIAKTVVGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ31</accession>
    <name>A0A1U9NQ31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Phycisphaerae</taxon>
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    </organism>
    <reference evidence="3" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70041">
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        <property type="gene ID" value="STSP2_03243"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03243"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="45" mass="5242" checksum="E665C89F1029F90E" modified="2017-06-07" version="1">MKKRFSGPQIGAKLRQADVLIGQGKTVPGYAKRSRSRHRWRRHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ36</accession>
    <name>A0A1U9NQ36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03221"/>
    <dbReference type="EnsemblBacteria" id="AQT70019">
        <property type="protein sequence ID" value="AQT70019"/>
        <property type="gene ID" value="STSP2_03221"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03221"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572552" evidence="1">
        <location>
            <begin position="24"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="344"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="694" mass="76990" checksum="D98CC6DB921B7077" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC0</accession>
    <name>A0A1U9NQC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transaldolase B</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">talB</name>
        <name evidence="1" type="ORF">STSP2_03336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03336"/>
    <dbReference type="EnsemblBacteria" id="AQT70132">
        <property type="protein sequence ID" value="AQT70132"/>
        <property type="gene ID" value="STSP2_03336"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03336"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="47977" checksum="24239F9FCB6B7F10" modified="2017-06-07" version="1">MSITKHKTDFIKTIQAFVLRDFSPNFDRLSSQFRPDPKWNRLREIGTALWLDTGNIEATLENWTREFSALTVNNTLLNREIQSGVYDDLIPEAFKLLKQEGCEGEQEFKLELAFILNAIHGLKLIEKFDAFVSLEEHTDLAYDLEGSLGYARRYYAICPERVYVKIPFTPAGVLASRRLSKENVPINLTLGFSARQNYVTARLANPAYLNVFLGRLNSFTEKNGLGTGEYVGEKATLASQAAVARLRQHGKTVSQQIAASVRSGQQIVDLAGVDVITMPPKAAKQFAEMEIGIDEIQDRRAHEYAPGIKADADQEKLGFDTLWRVDEKIVACMDDLDNENVDSFTPEDLVGFFSEHGCGDVFVEWDESQKQTSYEEGKIPKLGNWQEALTSGSIGLDSLMNLAGLSSFKADQDEMDEHVFKIIDEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC3</accession>
    <name>A0A1U9NQC3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhdJ</name>
        <name evidence="7" type="ORF">STSP2_03313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03313"/>
    <dbReference type="REBASE" id="191444">
        <property type="entry name" value="M.PbaBD1ORF3313P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70109">
        <property type="protein sequence ID" value="AQT70109"/>
        <property type="gene ID" value="STSP2_03313"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03313"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="319" mass="37261" checksum="93C98FBB4B55B3DA" modified="2017-06-07" version="1">MQNFKNKILCGDCIEMLNGVDEPVADLIFADPPFNIGYEYDKYKDTLKSEKYITWTRDWMGACVNALKPHGSFYIAIGDDYAHHIRLIGEQLGLTLRNWIIWHYTFGQQTKTMFARSHTHIFYFVKDKADHVFNDHAVRVPSDRQLVYADKRANPRGKMPDDVWNTFSRVCGTFKEREGWHPCQMPELLLGRIVSVSSNRGDLVLDPFNGSGTTVAAAYQLERDYCGIDISSNYVENSRKRLEKLAQERQNLQKDGEILDMRQRIELKRFYFEVRKDVSEILRRKSLLEIFTKLYNIRLNEERKFDPQEVATALQGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC7</accession>
    <name>A0A1U9NQC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">blaR1</name>
        <name evidence="4" type="ORF">STSP2_03188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03188"/>
    <dbReference type="EnsemblBacteria" id="AQT69987">
        <property type="protein sequence ID" value="AQT69987"/>
        <property type="gene ID" value="STSP2_03188"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03188"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="132"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="442" mass="48852" checksum="2F5437348668C79E" modified="2017-06-07" version="1">MSAILDIFTDQLIRTATLALAHSLWQGTVIALLLWLYLRSSRSAPATRYAVSFLAIIILAATPILTYSLISLDTPAPSYTTTEYVPRAQKQTQTQTQPQAHANGADLPAEPPISQNNGTNPDTQPASAKPAPAKSSEHHVTASTLTTLKHHWPRILFTAYILGVAAMLIRLLAHLTGTLTLKRSLTPDTDPDRNAVLTALASRARIARNITLALSNRVLVPCTVGLIKPVIILPASLITGLDENQLRAVLAHELMHIKRHDWICTILQMLIEALLFFNPATWWIGRQIRLEREAACDRSALSSRITPRDYARLLFDFASAHKTKAVAPAFSSANPPQLTERIKRLLTPTYRSAAIRPGIIPSVIVIAFFILAFVYFHKATESTLKYVGENLSPQQRAQTMQQISEDYSDNTSLLPEDQKITVSGTITTEDNKPLPNPYLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE1</accession>
    <name>A0A1U9NQE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="2">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">degP1</name>
        <name evidence="2" type="ORF">STSP2_03198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.107" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69997">
        <property type="protein sequence ID" value="AQT69997"/>
        <property type="gene ID" value="STSP2_03198"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03198"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="225"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="360" mass="39038" checksum="FF4D5593B9F35A2F" modified="2017-06-07" version="1" precursor="true">MSKAKWTPRAIVLFIFFLTMLTGLISLTILAPATADNTGPDTAESSKQSPDLPQQNLYDHVAPASVEILVDGRLAGSGCFVAPTGLVITAEHVLAHPDRRIEVITNTRDRIPASVVAVNCAHDLALLQVDSDRENFPYLPIAEKTPPASTPAYVFGAPVFRHGVMLAGRVARNQTAFEWYGSEKEYIEIIHFSALAPQGMSGGPWFDSEGQLIGIQSGGMVLDGGHVGISFVAPARPLRELVKNKKTVQTPTLAIACEEMWEQGSNPLKNGESIEGLIVRIVCEPGPSFSAGLKPDDIITAVEGEKVRYRDELLHAVRSRKTGQTVNLTVISPDNPEPRDVDVTLTALEKEWLDKDAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF2</accession>
    <name>A0A1U9NQF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70007">
        <property type="protein sequence ID" value="AQT70007"/>
        <property type="gene ID" value="STSP2_03208"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03208"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="430" mass="47596" checksum="04922B7F657D43C9" modified="2017-06-07" version="1">MRICLHYGEGEVRVDIPEENLQDVIRPWSAGGEGNCLAMAERMLGRVEGENFSESVAGRNVCVLIADGTRDFPLDDVLPGLVHLLMGAERVSFGIATGTHDADTEANGRIIEQIRRIAEREGLVHYDIFVHDCEGAEFAELGVTSRGTPVRVNEKVLGADVYVVLSDVKPHYFGGYSNPVKYFLPGMCAYETVEKNHALALDELSTFCVHPWCGDEGRRGNPLARDQLEGMEMIVGGREVWAVAIVSSGGKALWGEFGLAEEVSREAFEVSDERNVREVGKADRLIVSPGGLPNDVDLYISQRALELTGQAVRDGGEVLFVSACPGGVGAERTRANFYDRLTQPLEDVLASIDEEYVLFAHKPYKFAQMIRRLRKLWVYSEMDDETIRRAHMEPAGDVQKVVDEWIRQEPGCRITVVDGANKLALRAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF3</accession>
    <name>A0A1U9NQF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70163">
        <property type="protein sequence ID" value="AQT70163"/>
        <property type="gene ID" value="STSP2_03368"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03368"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211453" evidence="1">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32804" checksum="C14A8DF79DAE6DD3" modified="2017-06-07" version="1" precursor="true">MKKRILAILVCAAGLVSGCGDARQKTVSNGKLLEGVTLDAIKPSAPAVPDTKQHHFAVHIIELPAENFPALTTAYDSLTKGRLKHTNENIFNSNGFAVHRADIKQWSQAAQILENAHARSRISRNIILPEQDGHDIRIASSRRPQRVSYVDLTASSVRKTLDPGEIAWRMHARGTDQRGQALVSMEAVFKHFDSAKLRTPGKDPKEDDLVFKFSKFRTLINEGEFILLGPARYEAEARNLANMFFTTHADFIVPAEDSEKNPQDGPIIKRSHIIKKNIPIIKLYLIRCERVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF7</accession>
    <name>A0A1U9NQF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69974">
        <property type="protein sequence ID" value="AQT69974"/>
        <property type="gene ID" value="STSP2_03174"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03174"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16810" checksum="BD9743203A46830F" modified="2017-06-07" version="1">MTTYETLTKAREAAKTIDGARMVIEIDHAAEGRCYIVTKCNLKMLRNALSRKPMAEIDRVVDEHCITEPTEPSETEKLLAKRASLVSRSYSSAHPASAAYAAAMQAAKDLEAFDADNPEIAAQAKQQAAEAAADRQARIESSDRCRRIRNLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK2</accession>
    <name>A0A1U9NQK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">tig</name>
        <name evidence="13" type="ORF">STSP2_03309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03309"/>
    <dbReference type="EnsemblBacteria" id="AQT70105">
        <property type="protein sequence ID" value="AQT70105"/>
        <property type="gene ID" value="STSP2_03309"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03309"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="280"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="54401" checksum="4A2F133C85B07766" modified="2017-06-07" version="1">MAEEKEGTQVENVVKVEDAGPCKKRIAVEIPEEKIQNALEEQYSDLRKEAVIPGFRKGRAPRRLIEKRFGSDVSQQVKVQLLAEASEEAIKDQDLNILGDPDIDPDDIELPDAGPMNFDFEVEVRPEFDLPELEGIEVEKQKVEVTEESVDEELMEMRKRAGVWEPKEDGVVEDGNQVIADVVLSVEGEEEPERKDNVEIYAREKAMVAGVSVEKLNELLAGAKEGDVKKTTVEVPKTYFSERFRGKKVDLEITVKDVKKQVPAEIDDEFLGRFGVEDEEELKERIMEAREQQAEQQQRQQMGDQIYQYLLKNTDFEMPESIVADQATRILQRQYSNMLMQGTPKEQMEQQMQELRASSEEQAKEQMKLFFIMDKIADKLDVDVSGEELNGHIAQAAMYRGRRPEKMREEMLRDGSLAQFSLQVRESKCIEQLLEKAEIKEVEGEKKAETKKTAKKKTAKKKKAAPKKSENKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQK5</accession>
    <name>A0A1U9NQK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">STSP2_03417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03417"/>
    <dbReference type="EnsemblBacteria" id="AQT70211">
        <property type="protein sequence ID" value="AQT70211"/>
        <property type="gene ID" value="STSP2_03417"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03417"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22792" checksum="CB83EAB71543494A" modified="2017-06-07" version="1">MSRRILVASTNPGKMRELSALLDLDIEWLTLKDFPDVPEVVEDGKTFEENSRKKALGYANATGEWTIADDSGLAVDALDGAPGIHSARFSGPKDPAEQRSLIDHRNIAKVLELMKDVPESERTARFVCCICLAAPGRVLVETRGTMEGIITKKEIGTGGFGYDPIMFIPEKNKTAAELSADEKNELSHRGEAIKKLKPSLQDILRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR6</accession>
    <name>A0A1U9NQR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LexA repressor</fullName>
            <ecNumber evidence="2">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lexA_4</name>
        <name evidence="2" type="ORF">STSP2_03479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.88" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03479"/>
    <dbReference type="EnsemblBacteria" id="AQT70273">
        <property type="protein sequence ID" value="AQT70273"/>
        <property type="gene ID" value="STSP2_03479"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03479"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29319" checksum="AF19BCE9152594DD" modified="2017-06-07" version="1">MALGQIIRRRRIELNLTLDEVAAKIGFSKPYVSTVETGKVKNPPSDNFLKRLEEVLQFEKGLLQHIAHLERLPADIRRDYEAIDAENRKFRQLIKNIVEKKTDPGSIGGVVSLEELGLDIEEGAKRPVTAGQLVPVINKVAAGYPVDFDDLGYPAGFADDYVRCPDLHDPNAFAVRVVGDSMEPKFNEGDIVVFSPAADVHSGDDCFVRFTMPHETTFKRVYFEDSGLRLQPRNQNYAPRFVEGDRVNGIYRAVIRYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS1</accession>
    <name>A0A1U9NQS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylaminoimidazole carboxylase, catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03370"/>
    <dbReference type="EnsemblBacteria" id="AQT70165">
        <property type="protein sequence ID" value="AQT70165"/>
        <property type="gene ID" value="STSP2_03370"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03370"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="27839" checksum="E0E7C6A25F7CD9FF" modified="2017-06-07" version="1">MDDKKLTQLLADVKSDQITIDDAVEKLRHLPFEDMGFARIDHHRHIRCGFPEVIYCPGKTTEHIVKIFLLLAKKGNNVIASRADREVYDAIAAQLDHPGLRYEELARMVILDQCDMPPTEHYIAVVTAGTADLPVATEAKLTAETMGQRTEFVCDVGVAGIHRLIGHSRTMEILREASVVIVVAGMEGALASVVGGLVNSPVIGVPTSVGYGANFQGLSALLTMLNSCASGITVVNIDNGFGAGYAASMINARLEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR50</accession>
    <name>A0A1U9NR50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70198">
        <property type="protein sequence ID" value="AQT70198"/>
        <property type="gene ID" value="STSP2_03403"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03403"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="125" mass="14458" checksum="75A9DE613D146AC9" modified="2017-06-07" version="1">MKFTGHEIELARQIKEAGIEWTPEVGQYVFDTHGIIDKPSPFQDHVYFILSMSQFVRIFGSAEEIAANCVWLPTWEQCRQILERRGVTNEQLMENLRRSQAIEKGNERTVLYELILQSCRAKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRR7</accession>
    <name>A0A1U9NRR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03422"/>
    <dbReference type="EnsemblBacteria" id="AQT70216">
        <property type="protein sequence ID" value="AQT70216"/>
        <property type="gene ID" value="STSP2_03422"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03422"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12398" checksum="2635A9AD416B82C2" modified="2017-06-07" version="1">MAEFDDLNNMDDASDSFETVEPIGMRVVIRKDEDKKETKGGIQLPDNIEIPTITGRIVSVSAEVEITAELPLKQYDKVLFNPKGAIPVDFEGDNRLFVVDVENVVAVFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS5</accession>
    <name>A0A1U9NGS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wapA_1</name>
        <name evidence="2" type="ORF">STSP2_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67129">
        <property type="protein sequence ID" value="AQT67129"/>
        <property type="gene ID" value="STSP2_00270"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00270"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="429" mass="48130" checksum="B34FFDAE5AE60A5E" modified="2017-06-07" version="1">MPYHDTTTESFGMDDLGNRGTVGLRDNTTDTYVVQPYAANEYASIDSVSLTYDNAGNMTADHRGFEYEYDYENRLVKVTNPGQSVTVAEFDYDALGRRIRRGKYDSQGWQNRLYYYNDNWQVLEEYSIGSSGSGMVWRCVYGNYIDEPLVRSGGATFFYIQDHLYSTAALLNYNGSIAERYEYDAYGNATIWDASFSTTYDRSPNFNEYTFTGRRLDSLHANQLKLMYYRHRYYDPQMGRFLTRDPLGIVPNSKETVMSPYAAHWLGLNLFTGQNLYEYTYSAPLIYLDPAGLFGQCGPGFIGGIIVPDDPWPFGGANFTEACKAHDDCYGGEGPNGCRADKEECDDAFRDAMYAACDAKYGDEKDWFGNPRADWCKEKIADTYYGAVDDHGDASWEKGQENGNCPDPCPGATPGIGPGGNGGGVIRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW2</accession>
    <name>A0A1U9NGW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluD</name>
        <name evidence="6" type="ORF">STSP2_00315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00315"/>
    <dbReference type="EnsemblBacteria" id="AQT67172">
        <property type="protein sequence ID" value="AQT67172"/>
        <property type="gene ID" value="STSP2_00315"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00315"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="355" mass="40730" checksum="367D710650D436A6" modified="2017-06-07" version="1">MSSKKREEKLRANDQAGQDGNGGDDEDGEDEDELAGEELRFKVGTNLKYRRLDKYLGGRFSQFSRTKLQKLIKEQGVNVNGRPAKPSYKLNPKDEIDLILPPKEVRELIPEDIPINVIYEDDEMIVVNKQAGLIVHPARGYKSGTLVNGLVYYFQNQLSSVDEDYRPGIVHRLDRNTTGVMVVAKNDTAHWKLSRQFQERTTKKFYITVVHGSPELDADMINAPIGVHPHVREKMAVRPGGKEAISFYEVLERFRGYSLLKMGLKTGRTHQLRVHLAYLKHPIVADDMYGGKVVYPWQLEDREAAPEEPVMGRVALHAWKLFIKHPVSDEEMEFTADPPEDMQRFLDELRKYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ5</accession>
    <name>A0A1U9NGZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67203">
        <property type="protein sequence ID" value="AQT67203"/>
        <property type="gene ID" value="STSP2_00346"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00346"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10387" checksum="B6E533AE1BC83159" modified="2017-06-07" version="1">MIKLEWKSLLVGVVIGAGCLIFMGAKLGPVERRIATRPVGRFELYFTEDNALMVDTMTGQVWNRITLTKTGHRIVNQDFYKNKLELKSDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ8</accession>
    <name>A0A1U9NGZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67014">
        <property type="protein sequence ID" value="AQT67014"/>
        <property type="gene ID" value="STSP2_00152"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00152"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9702" checksum="01732262DBE1AF61" modified="2017-06-07" version="1">MKGDWLKRYEPIILVFVLTYLFYVDINTRIVNWLILFYLLAELVRAVIQHKQLEKETLIRRISLSIVVIGILLFVLLRGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH11</accession>
    <name>A0A1U9NH11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67222">
        <property type="protein sequence ID" value="AQT67222"/>
        <property type="gene ID" value="STSP2_00365"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00365"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17248" checksum="246F4F872E7D5C3F" modified="2017-06-07" version="1">MGLWEKVAERCDITITSTVAEDEVDFWEDEAGERHYIDLNESSFKQVDVPLDSVIQFKSRFLGDYFERLDPGEVESLTYLCSSKEHFLICSGDSIVFRILGLIARSGQGISLEELLSKIGLGRQLEWRNTKDFRIKYTKLGEQDSVTGTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH30</accession>
    <name>A0A1U9NH30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase 2</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA2</name>
        <name evidence="3" type="ORF">STSP2_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00385"/>
    <dbReference type="EnsemblBacteria" id="AQT67242">
        <property type="protein sequence ID" value="AQT67242"/>
        <property type="gene ID" value="STSP2_00385"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00385"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="37603" checksum="55F14C1D727FD8D2" modified="2017-06-07" version="1">MTPTGHSALDNRIVIGITMGDPGGVGPEIIVKALSDANLRREAKFIIFGSDEQLQYAADLAEVEPYWIRHQHEKISRDYPRHVVVADYDEYAIPGWIHSPNKVSGEASIKYCVDAIKAAQEGIIDGVVTAPISKVSWTMAGAKWPGHTEMFADQCKSRRKAMMFVGGPLKLALATIHEGLFEIRHHFTMGCVFEPIDLLNTALKEYFGVENPRIGVAGLNPHAGEDGQFGDEEERIIKPTITMAREVGIDCEGPFPADTLFLKAVRGDFDGVVAMYHDQGLIPIKLVAFDKAVNVTIGIPIIRTSPAHGTAFDIAGKGVAREESMKEAIKVAIEMAKTRAARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH38</accession>
    <name>A0A1U9NH38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67054">
        <property type="protein sequence ID" value="AQT67054"/>
        <property type="gene ID" value="STSP2_00194"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00194"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6624" checksum="94B5FC47D1119816" modified="2017-06-07" version="1">MAFMPWILLFLCAMAGEWMFSMAGSAARGAFCRRVCGAAASVLTMVMLISVVMAVVAAAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH71</accession>
    <name>A0A1U9NH71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67117">
        <property type="protein sequence ID" value="AQT67117"/>
        <property type="gene ID" value="STSP2_00258"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00258"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18580" checksum="10E66F719DF5D239" modified="2017-06-07" version="1">MSKADELNREDEAGKAQEDDKLVPVSEAIKYRKRAQAAEQERAELDAKLREMVANKTKVEQDLAEIKCDHELSRKLSAAGAIDLEAAVLMAKSKLAEDESGDVESVVESMRREKSYLFGGVGGVEKTAGVREKAGGGRGNLENLAKRAVKSGRRSDVQEYLRERRKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB8</accession>
    <name>A0A1U9NHB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67323">
        <property type="protein sequence ID" value="AQT67323"/>
        <property type="gene ID" value="STSP2_00466"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00466"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23792" checksum="F536222B1B4979A7" modified="2017-06-07" version="1">MKRLVNCVIAGLLICLIWGIIAYLTGIKAGVFAWAVSASVGICFASGSEGNKSKVFLAIVIASSAILLGKFIETTAENMEFTRKTTADTSENIEHDELMVAYIAHILADDLERQGKKVQWPAVVNNQRWWDKGNFPVGIWEEAKGYWDSIDAKEKQSLRETAKEKIMEDVGEFAFYPEKAGFIFGVSDVLMFVLAGFTTYIISGKNTKSFQKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC5</accession>
    <name>A0A1U9NHC5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">exo I_2</name>
        <name evidence="9" type="ORF">STSP2_00462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67319">
        <property type="protein sequence ID" value="AQT67319"/>
        <property type="gene ID" value="STSP2_00462"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00462"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013115395" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="158"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="CHB_HEX_C" evidence="8">
        <location>
            <begin position="517"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="843" mass="94933" checksum="6987C0272DD7AD71" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH2</accession>
    <name>A0A1U9NHH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rnfC</name>
        <name evidence="11" type="ORF">STSP2_00503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00503"/>
    <dbReference type="EnsemblBacteria" id="AQT67359">
        <property type="protein sequence ID" value="AQT67359"/>
        <property type="gene ID" value="STSP2_00503"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00503"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="393" mass="42334" checksum="F6E472609733B21C" modified="2017-06-07" version="1">MIGTTDAFVSSPVHSPVNGTVKDIALRSHPVLGRTEAIVIDTDEENPGIKTPVADRFDASFDENKFTAQQIGDAIKNAGIVGMGGAGFPTRVKVEPDTEPKKHTMLINACECEPYITCDYRVMLEWTYQFIAGIKLAKKISGCKRVCIGVEDNKTEALQVLKEAIEKASPDFELIPLQTKYPQGGEKQLIKAVLDQDVPLGGIPPQIGLLVMNVATCAAIAEAVVLDQPLTHRALTVTGHGINSPGNFYVPIGTPIQEIIDLCGGLKDSAVKVILGGPMMGFAVGDLSTPVTKTCGSILVLSKDEISKAKFERKQTPCIRCGRCLEVCPANINPTKIAHSVKHNMLDLAEQYHMAACIECGCCSYICPANIEITGHIKTGKVLKARQQKKMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN8</accession>
    <name>A0A1U9NHN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase Do</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67264">
        <property type="protein sequence ID" value="AQT67264"/>
        <property type="gene ID" value="STSP2_00407"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00407"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041517">
        <property type="entry name" value="DEGP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17815">
        <property type="entry name" value="PDZ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866379" evidence="1">
        <location>
            <begin position="24"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="497" mass="55555" checksum="3263033A3C1BA2B7" modified="2017-06-07" version="1" precursor="true">MKLNHKVLTIIAALLLIQSTLLAQPNTSEDAAEGIEKSLLFLEITSSAYENMQPWKKATMSSSYGYACAVGPYEVLTTAWNVTDTAHIKARLHGRNEFVPATVKVVDYEIDLALLELDREEMDAPLTPVTFSNDYAKGASVSSHWLTAGGRHKTGRGYIDRADVYKAPASYTSMLNYIIGNTSNTDSRGRLYCLDEKPVGLACWSDGDSKETGVIPTQIIDRFLADARDGEYKGFGSVGFSITKLIDPAMRNYLDMPDGEDNGVYVNDVYTLGTGSDTLEQGDVILAINGLAMNAYGRYEHPTYGRIQMAQIFAETPVGDNIEFTLWRDGKKITLSAPAEKFTAQDMLVPYYEYGMQPEYFVTAGFVFQKLTRPYMQMWGDDFAGKITPHIYNYYRDTAFSPTEDRQDVIMLSFVLPHQVNLGYHDLRGKIVKSVNGRTIESMQDFVSAFQLNPDAQHDVIEFEQDNPTVVIPRDQAKTADMMIAQRFGVTQQQNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT9</accession>
    <name>A0A1U9NHT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxal phosphate phosphatase YigL</fullName>
            <ecNumber evidence="1">3.1.3.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yigL</name>
        <name evidence="1" type="ORF">STSP2_00313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.74" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00313"/>
    <dbReference type="EnsemblBacteria" id="AQT67170">
        <property type="protein sequence ID" value="AQT67170"/>
        <property type="gene ID" value="STSP2_00313"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00313"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033883">
        <property type="term" value="F:pyridoxal phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32805" checksum="CF322E9411F63962" modified="2017-06-07" version="1">MTADKQKSAPVYISDLDGTLLRDDASLSNYARDTLRKLLRAGVNFTVASARAASSIRYIMKDLPLSLPVIEINGAFITEFATGRHLVINQMPTDLVQDIYRLILRYNCRPFLTTTTGDADHLYYDTIANDGMLWYYENRHKARDHRLQQTDRLQSCFTEHVVGLTVINTGPQLRNLAQHLLDEYKNRLEMHFFENPYSPPWHWLTIHDKTACKSRAIPELLEYANLDPAQLTVFGDNLNDANMFRTAPRAVAVENATDQIKSLATQVIGPNSDDAVIKFINQETNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX4</accession>
    <name>A0A1U9NHX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67529">
        <property type="protein sequence ID" value="AQT67529"/>
        <property type="gene ID" value="STSP2_00677"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00677"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16184" checksum="079284F808D980F8" modified="2017-06-07" version="1">MATANCSNVIRESLVQALETMAFMTAEESMDVPTEENAIVTAVDFEGPVSGRIFLWAGMEFAREFGQNLSGGFEIADEHCVDGLSELLNVTCGLVLPMVASSPTDTFDMRVPRRVAEGNEDWEIFVSGDEVIRLNVEGHPVAVKMVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX6</accession>
    <name>A0A1U9NHX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67367">
        <property type="protein sequence ID" value="AQT67367"/>
        <property type="gene ID" value="STSP2_00511"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00511"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9447" checksum="43741BEF7AACDD37" modified="2017-06-07" version="1">MSREKKVMLSGAGVSCALGLVTIGPPDLISQWFYATVSVAVYFMYVGVLRVVLGRITGIKQAVIFAVMGVLTAYAGTWGFLWIMRGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI82</accession>
    <name>A0A1U9NI82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein YjjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yjjK</name>
        <name evidence="6" type="ORF">STSP2_00453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00453"/>
    <dbReference type="EnsemblBacteria" id="AQT67310">
        <property type="protein sequence ID" value="AQT67310"/>
        <property type="gene ID" value="STSP2_00453"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00453"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="331"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="654" mass="73721" checksum="7274945B8DEE2C40" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI95</accession>
    <name>A0A1U9NI95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67649">
        <property type="protein sequence ID" value="AQT67649"/>
        <property type="gene ID" value="STSP2_00797"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00797"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14347" checksum="A0F6AD13E7B2CD84" modified="2017-06-07" version="1">MNQVETNEQRREARLRYSWPVWYAETLSDMLAQGQMVDVSSQGAAFTCYADRCPKDGDKVTTRFSVPTCDASDPFDLESFVREGSVCRVEELSPFVRKVAMQFAEPLPFNPADAPKDGLLDEELETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID6</accession>
    <name>A0A1U9NID6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immunogenic protein MPT70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67693">
        <property type="protein sequence ID" value="AQT67693"/>
        <property type="gene ID" value="STSP2_00841"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00841"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="PTHR13194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256715" evidence="2">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="200"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="46155" checksum="6B1ED18B858D20BB" modified="2017-06-07" version="1" precursor="true">MRHLRTNAVILLITLFSLSTGIAAESSQKTLFDFTGESAESKWLSVNDTVMGGISEGRARVSEDNTLVFSGNLSLENQGGFASIRSKPTDLNLEAYEAFALRVRGDGRPYYFDIRPSSRNSATSYRATLKTQKDTWKEVRFPIDSFEYTTFGRRVSGVAPPKAGDIQSVGFTLSDKKAGPFRLEVASIRAIKTDAAAKNDKDIVETAVAAGQFETLVAALKAAGLVETLKGDGPFTVFAPTDKAFAKLPKGTVDELLKEENRDKLTAILTYHVLPSKILLASQDSETIQGQTLAIKTSGSFTVNNAKVITPDIPASNGVIHVIDSVLLPATGKKTPRQDAKSVIELAISRGVPVFNAGQFSACAAIYEVTVESLLKSNENGLREAERETLRNALRETREEESPREKAWILRRALDSVYRSLNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE2</accession>
    <name>A0A1U9NIE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67681">
        <property type="protein sequence ID" value="AQT67681"/>
        <property type="gene ID" value="STSP2_00829"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00829"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="28396" checksum="0A98FA9E3713E1C1" modified="2017-06-07" version="1">MDSFTITILFIVASATVGAFFRRRTRDKCLRTFENDTVTYVPKTDGKQIKGVMRLESTGFELEYPPSAQDEHGSSSFIIYKEEYGKFLWLARYHDELSEKGKRDRDKDLRKTYRPWFGRRLKRHIINMFKTVRDSVGEILNVVLSAARKTRGVGVVLTSGDKYVTQMQSEVFAAVGTSFEPLLEKHIGQRVIVEAAQNDAAILLTGVLKDYTSGFLSIMDIENTEQGWGPDGRDVDVVIARQIATVRGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE6</accession>
    <name>A0A1U9NIE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67595">
        <property type="protein sequence ID" value="AQT67595"/>
        <property type="gene ID" value="STSP2_00743"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00743"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="24539" checksum="7A1AA00DAB01A079" modified="2017-06-07" version="1">MKRIIENKQIRGWRTFTLILYRGGPQWIAYNELDFEHRKEWDAFESILLKLSEDKNLLVCGSFSADFRNKAYYFHADAKDCWTGACLAQTESDLHDLLIHHPDEYYSFVVVARDVDAETLTNVLGPHLAKSVPICDLVVGHDEIFCGVEECIDRNRAELVCHVDDYDSIVGLITTLLSEYQVAKKPIIDSSDQVTILSSKALWEQMKKIIFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL1</accession>
    <name>A0A1U9NIL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemN</name>
        <name evidence="4" type="ORF">STSP2_00918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00918"/>
    <dbReference type="EnsemblBacteria" id="AQT67769">
        <property type="protein sequence ID" value="AQT67769"/>
        <property type="gene ID" value="STSP2_00918"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00918"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="387" mass="42860" checksum="F87774978B94684A" modified="2017-06-07" version="1">MTAQPRQPEPAGLYCHIPFCASKCRYCAFYSEPVSRHTTAELVTAMIAHLRRCDPAQPITTVYIGGGTPTCIPPADLLRLIDAIHNHFRITPDSREFTVEANPHHLTPSLLTGLRDHGVNRLSVGAQSFCDRELALLGRTHTADDITAAVRSARDAGYGNISLDLIFALPGSTLADWQRSLDAVLALAPEHISAYSLAYEPRTPFHRALEAGELTATDEETDRRMYELTIDTLTAAGYDHYEISNFARPHRRCRHNLTYWANDPYIGIGPAAASYYKGIRSTNTPDIPAYISALQQNDLPPQTETHTPTDLETACETAVLNLRRTAGIDLAEYKSRTHHDLRDLFAKEIDHNIRAGLLTLKNKSKNLALTPQALPIADKILTDFATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP7</accession>
    <name>A0A1U9NIP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KWG Leptospira</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00940"/>
    <dbReference type="EnsemblBacteria" id="AQT67791">
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        <property type="gene ID" value="STSP2_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00940"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010707249" evidence="1">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="450" mass="50282" checksum="9E1FC960834F5F50" modified="2017-06-07" version="1">MNGYKMVLFAILWSAIFGSTLALSGCSDGIPDVDPDAKMLSASKGHLFKVEMQDGKVGAIDGKGTIVILPDFAGLLGPYEQLDYIVGLHESFYNIFNKQGKLVSMGEGSASPVANDLVFVKNPGLLFGDPTFSPWLFNFKTNDKICKCQDVKPHNDLVCSEYVYNSRYIAVKKADKWGYVNPSGEVLIDFKFDDAENFRDDYAAAKFDGKWGVINTKGEPVIDFAFEEIWERGGPDNQFAVVCTESNRMRVYDMQGNWWQQAEYDLIFLYPRVITAGNEGEPFHAFTYAGTLVSRDYDVQGADSKGIIVKDSHGSHFHLDYSGKPLYDAKFNRLWSFHDGLAKAKTDSDLYGYIDETGSFVIKPQFITAADFNEGLADVIKPVQDGYVHGYINKKGEMAIKVATTETLKEPGVPTMFKFKHGLAKVKTKFWMGYVNAEGSWVWVSEKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS6</accession>
    <name>A0A1U9NIS6_9BACT</name>
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            <fullName evidence="2">Type III secretion low calcium response chaperone LcrH/SycD</fullName>
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    </protein>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="696" mass="79567" checksum="ACFEAC37439B4127" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIZ4</accession>
    <name>A0A1U9NIZ4_9BACT</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_00856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="match status" value="1"/>
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            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18780" checksum="F8ECF4B7B3527D25" modified="2017-06-07" version="1">MNLPAQVQQKMQTYFGSDQRRISHALQVLQIAEQIAVAEKTNLQLVKIAAILHDIGIHNSQRRYNSTAGRYQQIEGPPVARKIMTELDIDNETIEHVCDIIANHHSGGMNTMEFNCIWDADRIVNFAEEYPAHANLTETDYFDQILRTQTGKRIARANYTGIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ45</accession>
    <name>A0A1U9NJ45_9BACT</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="3" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
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        </source>
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        <source>
            <dbReference type="EMBL" id="AQT67941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8811" checksum="FA5A5C1915D66F74" modified="2017-06-07" version="1">MTCNDHQYENVCKDEFAQLTRKIDKLDDAIRGNGELGLKVRIDRLERAQATRNKLVWLITAAVITSSVSLLVQLVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ73</accession>
    <name>A0A1U9NJ73_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Phycisphaerae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_00714"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4551" checksum="145ED767A843EF2F" modified="2017-06-07" version="1">MLHVNESKAKLSICIGVKFWYSPAIYRINECGYFGAKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA7</accession>
    <name>A0A1U9NJA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide heptosyltransferase 1</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaC</name>
        <name evidence="2" type="ORF">STSP2_01155</name>
    </gene>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
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        <property type="protein sequence ID" value="AQT68001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01155"/>
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        <property type="gene ID" value="STSP2_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01155"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="39765" checksum="FA9218952B430432" modified="2017-06-07" version="1">MQKDKEHKRILIMKPSALGDVATALPALQAVRKRWPDARISWLVRPEFAPLLECVPAVDEIILFDRKLLGKFYKKEARRELAGLIRKLRGAKFDLVLDFQGLLRTALLGWISGCRRRYGMKGAREFAWLFYNHHVERPKDSLHVTDYYLKMTDECGARTDKVDYGIQIPEEAVGSAGRLLSHYAIDYGRYVVFICQSAHQWKCWPREKFAELADLVHDELKTPVVAVGTAGEREYIDEIAGMTDSFFVNLAGKTNLPELLAVLGNAKAVVTNDTGPGQIASTFDVPLVMVCGPSNPSRIGPYKREESVAAIDAFDRGEAIRSSYPGHRIECVGVEKVFERLRELIEHGSVSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC9</accession>
    <name>A0A1U9NJC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">STSP2_00774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00774"/>
    <dbReference type="EnsemblBacteria" id="AQT67626">
        <property type="protein sequence ID" value="AQT67626"/>
        <property type="gene ID" value="STSP2_00774"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00774"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17169" checksum="4142C42106AD5D0D" modified="2017-06-07" version="1">MSAGNIEITLNVEAPDVDIDTLRDLVMSVLDRYDATDATVSISIVGDEIITQVHQQFLGDEKTTDVISFDLSEAESENERIFDLVVNYEMASRQAQQRSHDAQAELALYITHGLLHNLGFDDIDPADAEKMHKAEDEILQTAGFGVVYAARPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE2</accession>
    <name>A0A1U9NJE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_01185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68031">
        <property type="protein sequence ID" value="AQT68031"/>
        <property type="gene ID" value="STSP2_01185"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01185"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="394" mass="42445" checksum="35E7A73427B4F67E" modified="2017-06-07" version="1">MLTVLIKTLLEAAPYIVLGFLVAGIIRELVPRDVLSKHLGAKGLRPLLKSVGIGSLLPLCSCGTIPLGIGLYRCGAAVGSILAFITSSPVLSPLVVILSMKLLGFKMAGMLLGFSLLTSFFVGLGGNAIFKGGDRESAGRVKSYEPIRRNESGGAIMRILRWSFRDFGGEASIDILIGLAVASAIISILPSEWISTWLGKQQLSTLIYVIIIGIPVYACSVPSVPIVQGLLLMGATPGAAIAYMLAGPATNLGELNAIRRHMGKWTAGYYSAGLIVFSLFAGLVTDKLIFPDYQYAARLLDNGELVVSQCCVPLIFGTETLGKMRLESVPLWHWPFGVLLAVILVLGAIKRVGEFVTDPCGNCVWREYGENTSCGGRCHVRRKHEWLRKLWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF1</accession>
    <name>A0A1U9NJF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetrathionate response regulatory protein TtrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ttrR</name>
        <name evidence="5" type="ORF">STSP2_01020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01020"/>
    <dbReference type="EnsemblBacteria" id="AQT67868">
        <property type="protein sequence ID" value="AQT67868"/>
        <property type="gene ID" value="STSP2_01020"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01020"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40373" checksum="3F5C102F064F4F8A" modified="2017-06-07" version="1">MNSGENEMVKGLQSVFEGLKGSGDGGRYMAQVLSQVPGGISISDMDGKIVFVNSVFARMFGYTPDEMVGKDVSIYAEHESTPGKAEALRREVKVQGEFKGEIYPKRRDGEQFTALAHMVQLKSPGGEPVGILCSVCEITDYKKTQEALCECESWSRVLVDTVPLGIQELDRDHKIVYCNAPYAQMLQYPREDVIGRKACDFASDEAEQARIEQCLNDIFEKEPAPAIWEGKNKTRQGDIIDLKINWNYRRDNDGKVVGLLAVVEDVTAKRRRKEMEQEWRVKLEGFHERMRRLTPREKEVMYLVAEGKPNKVVAMELDVSPRTVEIHRKRVMDKMEAGSLAELVRYLTKDEDLNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG1</accession>
    <name>A0A1U9NJG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner spore coat protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cotH</name>
        <name evidence="3" type="ORF">STSP2_01030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67878">
        <property type="protein sequence ID" value="AQT67878"/>
        <property type="gene ID" value="STSP2_01030"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01030"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1570" mass="175324" checksum="2C4150158D105ACD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH2</accession>
    <name>A0A1U9NJH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylR_1</name>
        <name evidence="2" type="ORF">STSP2_01238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68083">
        <property type="protein sequence ID" value="AQT68083"/>
        <property type="gene ID" value="STSP2_01238"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01238"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="35082" checksum="8FDFE97B560BF95A" modified="2017-06-07" version="1">MENFFSYLPISENNMRWDLYLTGAGAASIAAEDSYPPQGHPSLYSFRWETGRTLAEYQILLIAEGHGVFESAKNEQTQVKAGDVIFLYPDLWHRYRPDPSSGWKEYWLSWNGERLYRLMKKGLLDPNRGVISVQHPELIAAAFEKILKHVKDHPAENSNVLSAYAMEVLTLAMDDIDIAKVARDTAVPRDHVHSIDDPVVFKALQTIWNHSYRDIRVDDLIEMLPITRRTLERKFKESLGCSIGTEIKRCRLERAKHLLANTTLPIKHIALAVGFSSTDRMGKVFKESLGMTPSQYRKSVKDQHQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH5</accession>
    <name>A0A1U9NJH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00879"/>
    <dbReference type="EnsemblBacteria" id="AQT67730">
        <property type="protein sequence ID" value="AQT67730"/>
        <property type="gene ID" value="STSP2_00879"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00879"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33960" checksum="C7745EDC0679A667" modified="2017-06-07" version="1">MTTIRKIVIAGATGFIGQPLCRLLSNSGYEVIALSRYPDKHPELAKDKIRLVHWNGTDTWPTEALLSEDTAVINLAGENIASHKWTKTQKVRILHSRLQASKAIVEAIQDSHQKPAALIQASATGYYGHRPGEEVDEFAGPGNTFLSSVCVEWEDTMLPLADSPTRCAAARFGPVLSEHGGMLEKMLPAFKYWFGNYPAPGSQHVSWIHLEDTVKAVKLILETPQLSGPVNVTAPNPANAKQLARLISTAMRRPLPMPIPGFVLKLAMGEMAKELLLVDQNVLPRKLTEAGFEFKYPDLPAAIQDLIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI4</accession>
    <name>A0A1U9NJI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="10">APS reductase</shortName>
            <ecNumber evidence="6 10">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">cysH</name>
        <name evidence="12" type="ORF">STSP2_01046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="6 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01046"/>
    <dbReference type="EnsemblBacteria" id="AQT67894">
        <property type="protein sequence ID" value="AQT67894"/>
        <property type="gene ID" value="STSP2_01046"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01046"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="11">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="27037" checksum="111E9BD277C3B30C" modified="2017-06-07" version="1">MTNELIEKLQNIHDADELLAVAGKMFDGRIALASSFSAEDQIITEKIAKAGLAIEIFTLDTGRLPEETYKVIDATRRRYGIDIEVLAPDGDKLSEFVSKNGPNSFYDSVEKRKACCAIRKVEPLKRKLARLDAWICGLRAEQSPTRTDLQTVEWDAGNGLVKISPLAGWSTEMVWDYVRQNDVPYNKLHDMGYESIGCAPCTRAIKPGEDIRAGRWWWENPEHKECGLHLGPKKTETEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI8</accession>
    <name>A0A1U9NJI8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">STSP2_00824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00824"/>
    <dbReference type="EnsemblBacteria" id="AQT67676">
        <property type="protein sequence ID" value="AQT67676"/>
        <property type="gene ID" value="STSP2_00824"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00824"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="30981" checksum="A490EF52CCBA4BF5" modified="2017-06-07" version="1">MKVKVAEKCGFCPGVRNAINLARKTLAENSGGKVYCLGQIIHNNDIVDELSEAGLETVDSIDEIEGGTVLIRSHGATLAEIEELEKKGVRIVDATCVRVKRVQRIARELSKERYKVVVIGDENHPEVKAVVGYAENVAVIGSREDLHKLSGHGKLGVMCQTTQSPDHFSGTVAEIMDYGFSELKIVNTLCSETKKRQDAAVKLCKEVDVMFVLGGLHSANTRKLAELCKKHNNRTFHLQNWRELDKKLVCGIETVGVTAGASTPDRVIDSFVEHVKAFGEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK3</accession>
    <name>A0A1U9NJK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68101">
        <property type="protein sequence ID" value="AQT68101"/>
        <property type="gene ID" value="STSP2_01256"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01256"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5510" checksum="55258F3E0C8724B0" modified="2017-06-07" version="1">MNKFAITLSQVIFLIGLPEFPHHVAYLVVDKNQRVYIGSFQNLFSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL0</accession>
    <name>A0A1U9NJL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">V-type ATP synthase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68005">
        <property type="protein sequence ID" value="AQT68005"/>
        <property type="gene ID" value="STSP2_01159"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01159"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="101" mass="11430" checksum="68135415704F4DF2" modified="2017-06-07" version="1">MEIIKQIKEAEQQAKQIVEDAKAQAAQMHEKARKEQRQQTEQAQDSRRTQINAAVEQAEQDAQSEVEKLKQDGQAEVEQLKQKAGSKMDACVDKVLSHLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS9</accession>
    <name>A0A1U9NJS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67840">
        <property type="protein sequence ID" value="AQT67840"/>
        <property type="gene ID" value="STSP2_00991"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00991"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="16067" checksum="F2BCDD30A4F1422C" modified="2017-06-07" version="1">MRKVVWYIATLFVVAILLLIVWRLTWPLTPENYTLGAQIQTAISDAYKTGNIDTAIASLEEQSVIKPSSPSQVNMNRVLIVNPNPDTPPGEFVAIWHIDLWHSRDKGAAVLTNEGYLKTEINWKKLIKSDMDLKFYKIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ2</accession>
    <name>A0A1U9NJZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68242">
        <property type="protein sequence ID" value="AQT68242"/>
        <property type="gene ID" value="STSP2_01398"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01398"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12909" checksum="673673214A092693" modified="2017-06-07" version="1">MKKKFICEECGGSQIGYQEYVSSVSPVDYVGQEVYYGEPQIDESDSVCADFGFLCLDCGHRLFHAGQRIETEQDLQYYLNADRQVLAQENGAYVNHLEEHIEMLEKCRKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK07</accession>
    <name>A0A1U9NK07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01229"/>
    <dbReference type="EnsemblBacteria" id="AQT68074">
        <property type="protein sequence ID" value="AQT68074"/>
        <property type="gene ID" value="STSP2_01229"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01229"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="21796" checksum="42D612F08301A577" modified="2017-06-07" version="1">MDKMYNENSSNSNRNAEVFLRLLMANRRAIYSFVLSLVGSWSDADDVMQDTVTVMWRKYADFEEGTNFRAWAMQIARFKVFEHQRSKKERTGFDVEILKDLSSQSLRNSEDLDHRIEILQECLDKLAKKDRRLLKLRYEQDFSIKEVAKQTRRPFYGLYKAMARIHTSLLLCVRRGLRLEGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK81</accession>
    <name>A0A1U9NK81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional polymyxin resistance protein ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnA</name>
        <name evidence="2" type="ORF">STSP2_01492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01492"/>
    <dbReference type="EnsemblBacteria" id="AQT68333">
        <property type="protein sequence ID" value="AQT68333"/>
        <property type="gene ID" value="STSP2_01492"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01492"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29243" checksum="893E05936A822A5A" modified="2017-06-07" version="1">MKIIILTQEENLYLPQSFATVCRAFPDEVVCIVASPAMSTHGGAVKGFLKHFQLFGIRGTWIMACRLIIAKLKGRFAKPSSEGPFHSIKQVADGFDIPYYHVPKVREQQFQYILDKYRPDLLISISCPQIIGKKIRERIPMGCINVHGAPLPKYRGLMPAFWVLRNGETETATSVHDLMAKLDDGEILVQKKVAIDPNDTWDSLVTKTKAEGARALVEAIEQIKAGTVQRKPNREEDATYFSFPTAEDRKAFIKAGRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK85</accession>
    <name>A0A1U9NK85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01154"/>
    <dbReference type="EnsemblBacteria" id="AQT68000">
        <property type="protein sequence ID" value="AQT68000"/>
        <property type="gene ID" value="STSP2_01154"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01154"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16352" checksum="0008942675605099" modified="2017-06-07" version="1">MIALGAAMGIFVAFLPPLGFHTLLAIVLAIMFRANKAVTLMGAWLNNPVTCVPLYLSCYFVGSGITALAGESTVGPERVAVILTRFADVGNMWRSEFWRETGRAFLGIAMELTVGGFVLGGVCGAAAYFGVRKAVLVYRRNHPHRRFRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA2</accession>
    <name>A0A1U9NKA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpC</name>
        <name evidence="10" type="ORF">STSP2_01512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01512"/>
    <dbReference type="EnsemblBacteria" id="AQT68352">
        <property type="protein sequence ID" value="AQT68352"/>
        <property type="gene ID" value="STSP2_01512"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01512"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="5"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="271" mass="30400" checksum="D76540E3471D2501" modified="2017-06-07" version="1">MSDILQEIVAYKREFVREQMQKVPLEQVKEQALAMGKSRNFYKAVTKRNRRGINVIAEVKKASPSAGLIREDFDPVEIARTYEKCGADAISVLTDEKYFQGKLEYLTRIKQEVKLPVLRKDFFVDEYQVYEAKAAGADAILLIAEALMPAQLMDLLILAAKLTMTAIIEVHSMDSLLQVRSLEGFPVAGYSVIGVNNRDLKTMTVDINTTGRLADLVEKKRELIAESGVKTREDVRKLKGIGVGAVLIGQTLCQSPSIEDKYKELFWIPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ3</accession>
    <name>A0A1U9NKZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tfp pilus assembly protein PilX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68394">
        <property type="protein sequence ID" value="AQT68394"/>
        <property type="gene ID" value="STSP2_01554"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01554"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="469" mass="50042" checksum="4D36CA53D04E8110" modified="2017-06-07" version="1" precursor="true">MSAKKRKNTRPGFAMVMSMMFLVLFSSLAVGIFTTSSGNVEIADNQREGNLALVSAESGIDITRYWLNGIEVSGSVAPSNRLSEVYNTLTGRLNGASVTNLSVNYNSLEDKIEIPDPSVKDGVVLDGSSGQKFRAELRQLDGDTLELEVTGISGQISRKITTNFSFGQRSSRVFDYGVASKGPIEIKGNADIMGANDPSEASLYIESLDEHEALAMNGNVSIAGDVDIANPDGYVDMKGPGTIGGESGQDAIDNHVDIGVDTVEFPMPDCSEFEAWAVNTVDSSTKVNGNVTLENIRIEAGTNPTFGGNVTLRGVVYIESPNHVKFSGNTDLQGVIVAEGDIDNPVSGDKLEFTGNMDNMGVDELPSDSQFDGLREKTGTFIMAPGFEVEFKGNFDTIDGAIAASGIRFTGNAGGTITNSLINYSDETMTFQGNARVYIDRSDSDPDPSGFEGSYVLEFMQSTYSEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL18</accession>
    <name>A0A1U9NL18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anaerobic glycerol-3-phosphate dehydrogenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01662"/>
    <dbReference type="EnsemblBacteria" id="AQT68497">
        <property type="protein sequence ID" value="AQT68497"/>
        <property type="gene ID" value="STSP2_01662"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01662"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="602" mass="66290" checksum="5D1F7380022A904C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL70</accession>
    <name>A0A1U9NL70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68547">
        <property type="protein sequence ID" value="AQT68547"/>
        <property type="gene ID" value="STSP2_01714"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01714"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012595031" evidence="1">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="262" mass="27557" checksum="413058BCDF7BAB40" modified="2017-06-07" version="1" precursor="true">MKKSLTAVVLILAVSAGTVQAGTSFAGRVVSYDPSTASESGYTNPEAALGQIAVDTGWGATTPFNMPFTSDDFVTIGEGGHLTLELENYLLPGDGFELGVFSYQMFYQDGWPDGGTTDPVDLFRPTQMAVVEVSEGGSDWYALNGGDRIQMDMPAAAYSDAEATIESDFSKPFTVSLSDFDGLGSVQEVLDVFDGSAGGTWLDVSEAGLDRIGYVRFTVPYGDAFELEAVSIASGAIGAAVPEPLSILLLGTGACFLRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH6</accession>
    <name>A0A1U9NLH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dockerin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68346">
        <property type="protein sequence ID" value="AQT68346"/>
        <property type="gene ID" value="STSP2_01505"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01505"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012482497" description="Dockerin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24563" checksum="922B294E2B2C33D0" modified="2017-06-07" version="1" precursor="true">MMKRVLLLALCMLVNASVPAAPNMNVFRADGETPLEYQEIMVGTQLTLVISNDNADYWSGSVALYDPNIPMADITGREYNGFSYDGSCLPASGFGSAVYDWTEQGVRGFDLYAGYTGVTAGDWFVLDYKAVQVGECTVQMHEHNMPDGPAILIDEQTFIHVPTRDFNADSVVDYSDLVVMSRYWGQTDVADPSDVKGADLNEDGAVDMNDLLLFSCYWLEKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP1</accession>
    <name>A0A1U9NLP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase RfbM</fullName>
            <ecNumber evidence="2">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbM</name>
        <name evidence="2" type="ORF">STSP2_02038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.13" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02038"/>
    <dbReference type="EnsemblBacteria" id="AQT68862">
        <property type="protein sequence ID" value="AQT68862"/>
        <property type="gene ID" value="STSP2_02038"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02038"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40498" checksum="3F1C485282643E73" modified="2017-06-07" version="1">MDYAVIMAGGTGKRLWPLSRKSRPKQVLKLIEGNTLLRRCYDRLIPLFDPRNILVLTNAGYADIVRENLPDLPYGNVLAEPAVRDTAGAIGFAATVLSKYDPNARMAVVTADQLIEPTDVFQQALSDGLEYVKKNPDAMITFGIQPTFPSTQLGYIKVGEPHKCESCTNEIFDVDSFSEKPDIATSREYLSSGEYLWNSGMFIWQAKTILKNIEKYLPASKEPLKRIFAAWDGPRQEDVLKEWFIKMPKISIDYGVMEQAENVKAIRLNCSWRDMGSFSALADIISSDENNNIVVAGQSELIDSKNNILVTEDEDHLIAVIGLENMVVAHSPDATLVCPMDEAHRLKELLEVVKQHGGEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ0</accession>
    <name>A0A1U9NLQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c biogenesis protein CcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccsA</name>
        <name evidence="7" type="ORF">STSP2_02048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02048"/>
    <dbReference type="EnsemblBacteria" id="AQT68872">
        <property type="protein sequence ID" value="AQT68872"/>
        <property type="gene ID" value="STSP2_02048"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02048"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="63"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="29467" checksum="8091A6AE735B5C13" modified="2017-06-07" version="1">MEIKTNPLGILIYAAMFCYLAAFVVFVARKRKEGRLIYALGFVVACTAFVYRWVDVNHVPMKNLFEVFILMGVCIFPITYLSKRFLGTSGEAFDMAVGFIVMFPAGFVFDDSSMTLMPALQSPLFAPHVATYMVSYIFMAKAACQAAAQLIKLKPAGRLADYERSSYNMVCAGFPLMTLGLLLGSVWGKFAWGDYWGWDPKELWGLISWLVYVGYLHWRYMYGTKRPKANSVWVLAGFAAIIITLLWVNLSRLFSGMHSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ0</accession>
    <name>A0A1U9NLZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00391</name>
        <name evidence="3" type="ORF">STSP2_01729</name>
        <name evidence="4" type="ORF">STSP2_02021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67248">
        <property type="protein sequence ID" value="AQT67248"/>
        <property type="gene ID" value="STSP2_00391"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68561">
        <property type="protein sequence ID" value="AQT68561"/>
        <property type="gene ID" value="STSP2_01729"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68845">
        <property type="protein sequence ID" value="AQT68845"/>
        <property type="gene ID" value="STSP2_02021"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00391"/>
    <dbReference type="KEGG" id="alus:STSP2_01729"/>
    <dbReference type="KEGG" id="alus:STSP2_02021"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="89"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="276" mass="31674" checksum="1319F415B600A7AB" modified="2017-06-07" version="1">MIGQPRASQRYKSQQQPTNTALTSKIIELAKEHQSYGYRFITAKLRQHGWRVNHKRVQRIWRKEALQVPHRRKGRKTKGNSDNSCSVQKADYKDHVWTYDFVSDQSEDGRSLKFLTVLDEFTRESLTIEVGRSIKSGDVVETLEYLFAVRGVPGFIRSDNGPEFVASAIKKKLGKKNVETLYIEKGQPWENGFIESFNGKFRDEVLNRELFYSVKEAKVIVEQWRMEYNNHRPHSGLDYATPAEFAASCIASASPTAQLQQYTTDEKDNSLTVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM79</accession>
    <name>A0A1U9NM79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY_5</name>
        <name evidence="3" type="ORF">STSP2_02191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69013">
        <property type="protein sequence ID" value="AQT69013"/>
        <property type="gene ID" value="STSP2_02191"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02191"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15301" checksum="0B9CC9D6C8BDE954" modified="2017-06-07" version="1">MKCLIVEDDRSAQKLMQIYLSDFFECSVAENGVEALEEVVSSLESGTPYDLICMDIMMPEMDGMEALEKIRQAESKRGIEGLNCIKVIMTTAKQQSEDIFGAFRKGCEGYIVKPIRRADLIEQIEKLGLIKIEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM94</accession>
    <name>A0A1U9NM94_9BACT</name>
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        <submittedName>
            <fullName evidence="7">Inner membrane protein YrbG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yrbG</name>
        <name evidence="7" type="ORF">STSP2_02208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02208"/>
    <dbReference type="EnsemblBacteria" id="AQT69029">
        <property type="protein sequence ID" value="AQT69029"/>
        <property type="gene ID" value="STSP2_02208"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02208"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="182"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="34384" checksum="5FFD4950F6377D6E" modified="2017-06-07" version="1">MNLFLALLSLAGGIAVLIKGADVLVEGAVGIADKFGVSPLVVGLTIVAMGTSAPEVATSIAAALEGKGDAALGNVYGSNIANLALVGGVCSIIRPISVRLIMLRRELPVMILVALLLWPFLGLNSYLGRIESIALLILFASLITLTIRAERKAGKNRPDTVAAMASEVEEIKSHGVKSLRFYVIMVVIGLVALAVGARLSLLGAVFLGEKAGLSDFVIGCTILAIGTSLPELITSLVAAFKGHDDLSIGNLVGSNIFNTLLVVGCAGVISPFEVSERLAGTDYWIMIAVSIVFLLFAGVGRKISRKDGIVLASIYVGYMVYLLVFTRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF3</accession>
    <name>A0A1U9NMF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69089">
        <property type="protein sequence ID" value="AQT69089"/>
        <property type="gene ID" value="STSP2_02276"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02276"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12867" checksum="AC3F71A9A86FCD21" modified="2017-06-07" version="1">MGENAYYAVITSGGVYLCDTQNLFDYFLRNARATGFASVRRTIVLLSHQLAIPAKHCVRLKQRWHIRLNMPPQDNPFGRQSPPLGISQLQSLAAVVIHELLMKKFNNCRVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN4</accession>
    <name>A0A1U9NMN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68766">
        <property type="protein sequence ID" value="AQT68766"/>
        <property type="gene ID" value="STSP2_01938"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01938"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10686" checksum="824BF67FB11124BC" modified="2017-06-07" version="1">MRLWKVLRKQLKIFPYKNRYCFRAGFALPANISIALARLKLAIVVMADFTGRRTRKEPKADLSLNRHLAVKASNNVVDASIKEMLCASLAKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU6</accession>
    <name>A0A1U9NMU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69272">
        <property type="protein sequence ID" value="AQT69272"/>
        <property type="gene ID" value="STSP2_02461"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02461"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24738" checksum="081616299823CE5A" modified="2017-06-07" version="1">MFEKIAVTTLLITLLVIAGHYVYRLVRGAVKEGVCPACAIMRLPLRMISAMLLEQKLGFLGRVRKLVLLVGLLCFAVLAVTGFWPPLAEGEYLAGYMLMIHATFAPVLAICLAVAAVMYAYDCRFEQADWKGVLRLVKPEGRWEGGEKPAAPFLQRILFWVLMILSLPLMLSIALSMFPLFGTEMQEFLFEVHRYTALTMLICVLLQVYLAAVMPVCCNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW5</accession>
    <name>A0A1U9NMW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen accumulation regulator GarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">garA</name>
        <name evidence="3" type="ORF">STSP2_02481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69292">
        <property type="protein sequence ID" value="AQT69292"/>
        <property type="gene ID" value="STSP2_02481"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02481"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19554" checksum="E9C0A70A288C545A" modified="2017-06-07" version="1">MQVNLVLFKKNGEKKTFPLPSTATIIGRRQDCDLCIPLMMVSRRHCQLYIEDDKLMVRDLGSKNGTLLNNEEIDDETQVNPGDNLKIGPVTFIAQINGEPTQIESPAKPQTKAESDQKAKKHAEDFAGADEMAATANHHSSDDLADLDDLDDLDDDLIEDDDDDLSAELEKELSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY3</accession>
    <name>A0A1U9NMY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69088">
        <property type="protein sequence ID" value="AQT69088"/>
        <property type="gene ID" value="STSP2_02275"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02275"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7484" checksum="BE58D3EA00A56F5B" modified="2017-06-07" version="1">MCKTNSKPFVISKKSVWQAYHLVKSNRGGSGVDRVSLKEFEENLRTFRVTRPASMKTPGRRSDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN14</accession>
    <name>A0A1U9NN14_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcK_2</name>
        <name evidence="5" type="ORF">STSP2_02414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02414"/>
    <dbReference type="EnsemblBacteria" id="AQT69225">
        <property type="protein sequence ID" value="AQT69225"/>
        <property type="gene ID" value="STSP2_02414"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02414"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34539" checksum="3C20B29405348B0D" modified="2017-06-07" version="1">MKEFFIGVDFGGTNLKLGCFDGELNLVTKTSVPSGEDLSPQAVIANISSTIHSVLSQHEIAYDQVKAVGLGIPGQMNLTDGIILSAPNLPFENVPMKRLLSEKLDKTVIMENDANAAAWGEFVAGAGSDVNHMVFFTLGTGIGGGIICDGKLVHGYTDEAAELGHILIYVDGERQCGCGQYGCAEAYGSASATADRANDALKAGVDSSLNELFKKDGSVTCEQVFDHAKNGDKFANEIVDGTAKTLGILCIDMLHVTQPQRILFAGGMIGAGDFLLEKIQKYFDKYIWTMKPESLEICFATLGEDAGIIGSAALAKDHFKVSKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN35</accession>
    <name>A0A1U9NN35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">suhB_2</name>
        <name evidence="7" type="ORF">STSP2_02508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02508"/>
    <dbReference type="EnsemblBacteria" id="AQT69319">
        <property type="protein sequence ID" value="AQT69319"/>
        <property type="gene ID" value="STSP2_02508"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02508"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28685" checksum="0DC341B80DFB6E8E" modified="2017-06-07" version="1">MREFLKNIMIEAGRVALEQKQRLGEVKVDRKSEKDLVTEADVAVEEYLVGQIKERYPDHAIVGEETGEHEGGEYRWIIDPIDGTTSFVHDQPFFSTSVAVEKDGETVLGAVNAPVLGELFMAEKGKGATLNGEAIHVSDRERLIDSVLGTGFACVRQNLEHNNLPYFAEIVTRIRGVRRYGSAAMDLSYVACGRLDGFWELNLQIYDVAAGVLIVQEAGGVVSDFAGGEEGRPFETLATNGRIHEALSRELMEVQMRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN61</accession>
    <name>A0A1U9NN61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">thrS</name>
        <name evidence="12" type="ORF">STSP2_02235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02235"/>
    <dbReference type="EnsemblBacteria" id="AQT69050">
        <property type="protein sequence ID" value="AQT69050"/>
        <property type="gene ID" value="STSP2_02235"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02235"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="262"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="9">
        <location>
            <begin position="239"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="637" mass="72643" checksum="C34D550DC4E8EC20" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB3</accession>
    <name>A0A1U9NNB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-W factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigW_3</name>
        <name evidence="4" type="ORF">STSP2_02590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT69401"/>
        <property type="gene ID" value="STSP2_02590"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="23529" checksum="C8366E19F5ABB6EA" modified="2017-06-07" version="1">MKKKAVADRPSDAELLERYKEGDEDAFQEIVSRYKNPLYAFLRRFLNQQDLVEDVFQETFLQLYASKDKFDPSRPLHPWLFTIAANKAKDALRKQQRTSSLGLGAIADSGGVSVDDVVNLLDSYDLTPDAEATKDETAQRVREVVSKMPENLRGILILAYFEQFSYKQMAEILSIPIGTVKSRLHTAVVHFTKRWKELNRSSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB9</accession>
    <name>A0A1U9NNB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">xerD_3</name>
        <name evidence="9" type="synonym">xerC</name>
        <name evidence="13" type="ORF">STSP2_02417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02417"/>
    <dbReference type="EnsemblBacteria" id="AQT69228">
        <property type="protein sequence ID" value="AQT69228"/>
        <property type="gene ID" value="STSP2_02417"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02417"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
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    </dbReference>
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    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
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            <begin position="125"/>
            <end position="308"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="314" mass="35540" checksum="5F3C52E376976782" modified="2017-06-07" version="1">MSEAQIQKLHNRLGESGIGGEVIKFMHYLTVEAGLSQNTLLGYGRDLLGFAQWCEAEYGLDSISELRAEHIYGYARHVAKNLHSKETSIARILAAIKTFLRFGMSVGLIEDDLTSLIEGPKPWHKLPIVASRDNVLKMLHAPCEEDAFFLRDRALLEVLYATGARASEMVDLRVKNVNLKIGYLRCTGKGNKERVIPLGQSAIRAVEQYLQLERPQLAKPYSRDYLLLTRTGKVLDRTNIWRIVKKYAARVGMPEKVSTHTLRHCFATHMLSGGADLRSLQEMLGHVDISTTQIYTHVDHDRLKSIHKKFHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE2</accession>
    <name>A0A1U9NNE2_9BACT</name>
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        </submittedName>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="362"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69423.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="536" mass="60653" checksum="D2FF9E5730C4BD7F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG8</accession>
    <name>A0A1U9NNG8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">STSP2_02473</name>
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    <reference evidence="3" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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            <end position="204"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69284.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
    <sequence length="322" mass="36912" checksum="CF9EE49F5AAEBE11" modified="2017-06-07" version="1">MKQFLKQQGSRGDRLHLTFEISGQAGYLHDQLRGHVEDVTVSNPTRMTWIYRTSKKNDRIDARKQAVLLSIDEVPKVHMPRLEVRQWRVTIQHRRKMVSRVCQVKNRIRAIIKANGFSRPVESGSWWKSANRLWMRGLACFEADAEQLWRMSLADMLEELNMLESQLKRVTNYLDRYLAGQSGGKLLMSVPGVGPRTAEAILAYTDDIRRFRRTKQYCAYFGLTPKLDESGSTRRLGHISKQGPSVVRWLLVESAWQAIRKSPALKAFYEKVMNGQKGRGKIAAVAVARKLLSIMRAMLVNGELFNEELVGRSCGFDMRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI0</accession>
    <name>A0A1U9NNI0_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Efflux transporter, putative, hydrophobe/amphiphile efflux-3 (HAE3) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_02357"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02357"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MMPL_dom"/>
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        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="962" mass="106835" checksum="C683F8F849A0747B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ8</accession>
    <name>A0A1U9NNJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglX_2</name>
        <name evidence="3" type="ORF">STSP2_02377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02377"/>
    <dbReference type="EnsemblBacteria" id="AQT69190">
        <property type="protein sequence ID" value="AQT69190"/>
        <property type="gene ID" value="STSP2_02377"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02377"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="801"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="930" mass="102145" checksum="494AA264F35060E6" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK8</accession>
    <name>A0A1U9NNK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69318">
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        <property type="gene ID" value="STSP2_02507"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02507"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459823" evidence="1">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="27295" checksum="8962F59A8D9FFB93" modified="2017-06-07" version="1" precursor="true">MVRTIGFSILALALVGIVPSTVQAADDELGFDVTGGFFSKYVWRGQLITDDYVFQPDISVSYKGFTGGVWGNLELTDYSDNEGEFTEVDYYFDYSAATGIDGVGFSVGAIHYDFPSGGGIEGTTELYWGLDFDAPLDPYIVVYHDIDEVSGTYATAGVSKSFANFIEGIDMEVGASIGWGSSEYNEGYWGVSESGFNDLTVSAAWPTALGETGWTFTPSISYVTLVDNDLRDSDAFGTASDHFYTGLSLSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR6</accession>
    <name>A0A1U9NNR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69260">
        <property type="protein sequence ID" value="AQT69260"/>
        <property type="gene ID" value="STSP2_02449"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02449"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17922" checksum="591F958D82A43815" modified="2017-06-07" version="1">MTSEHIFIQEVLATHNISIQQLANAADLAAPTVYEYTGGRRKHIPLCIWRALYALTEDIRILDLIIGEVDRFVCPLPKTPDETHNDTLARLIEKRRKDIECEMAILEILADGQIDAEDRVAVEQYKNAHPESMKLSAQIYYSIIKKYEQAINGKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS9</accession>
    <name>A0A1U9NNS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69166">
        <property type="protein sequence ID" value="AQT69166"/>
        <property type="gene ID" value="STSP2_02353"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02353"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="73" mass="8264" checksum="8B1E86386469EA0A" modified="2017-06-07" version="1">MSANEFGNYIAGYAGVYHLGYGGWIGMRLAGNFYANQGRFWEREDEESIRDIDSGAGDAWGDRLEDDIRRNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT7</accession>
    <name>A0A1U9NNT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pimB_3</name>
        <name evidence="2" type="ORF">STSP2_02752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69559">
        <property type="protein sequence ID" value="AQT69559"/>
        <property type="gene ID" value="STSP2_02752"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02752"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="150"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="378" mass="42453" checksum="39300CB302774058" modified="2017-06-07" version="1">MKVLLMYEYPPYPGGLSTQGDLFAKGLKQVGVDVQQVHFQSAYEKEWYYRWYRPDVAVGIGYWGFTPDLVHHPQKHGIAAVPWLVADGYIADHRETLDSLPLILVTSQWVKEVYMRDGLKGQNIEVLPVGCDTDNFCPRSASDQKVAAVRETLGIDDDTLMILTAGGDAASKGAQEVMHALAMCNSDLPDWKYICKVYPGPRTLNQNELDRRLARELEIDDNVIYAMNVTSREFMPYLLAACDIYAAPSRIEGFGMIQVEAAACGKPVIGIKAMGLLDTMVHGENAYLAGIAQEVKMKETVICGCEGDRKRISFRRPRTVDYRASSYDIAGYLRELMSDPSLRERMGQAGRKRAVEKYDYRVVARQFLDIVKSRLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU0</accession>
    <name>A0A1U9NNU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus assembly protein, PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02766"/>
    <dbReference type="EnsemblBacteria" id="AQT69573">
        <property type="protein sequence ID" value="AQT69573"/>
        <property type="gene ID" value="STSP2_02766"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02766"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="20461" checksum="ACCEBD6562CDE6C5" modified="2017-06-07" version="1">MSTGFRKLIFFIVLIGLAYVAWAYMIKPANEDLKKQKAAVETKRAKLTQLENATRDAEDLSKQLTELDDAMSFFENKLPPKSEIHKVLENITMIAQKQGLKPKTIRTLKQKNTHGYVEQPLSMELSGNFSSYYQFLLEIENLDRISQIKELSLKKKSKFEGETEATFIVSIFFQDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV8</accession>
    <name>A0A1U9NNV8_9BACT</name>
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        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">STSP2_02716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AQT69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02716"/>
    <dbReference type="EnsemblBacteria" id="AQT69525">
        <property type="protein sequence ID" value="AQT69525"/>
        <property type="gene ID" value="STSP2_02716"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02716"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="315"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="542" mass="60785" checksum="7473809C4EA9E653" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP04</accession>
    <name>A0A1U9NP04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69464">
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        <property type="gene ID" value="STSP2_02654"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="15"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="874"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="908"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1391" mass="159883" checksum="54996694F1023E59" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP19</accession>
    <name>A0A1U9NP19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="2">5.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gmhA</name>
        <name evidence="2" type="ORF">STSP2_02539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02539"/>
    <dbReference type="EnsemblBacteria" id="AQT69350">
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        <property type="gene ID" value="STSP2_02539"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02539"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
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        <property type="entry name" value="SIS_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20069" checksum="774D080EAD683824" modified="2017-06-07" version="1">MKDAIQNCINEHKKLIEAFETDCIDSVAAAVDLLTDCFKAGGTVYLCGNGGSAADAQHVAGEFVGRLKHDKIALPAVALSVDCSVLTCVSNDYGFEEVFARQIQALGRKGDVLWAFSTSGTSKNVLKAVDAAKSQGLKIIGFVGRPDSPLEKLSDVCVGVDSQWSCGAQEVHQLAYHIICDLVERTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF5</accession>
    <name>A0A1U9NPF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpC_2</name>
        <name evidence="6" type="synonym">atpC</name>
        <name evidence="8" type="ORF">STSP2_02575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02575"/>
    <dbReference type="EnsemblBacteria" id="AQT69386">
        <property type="protein sequence ID" value="AQT69386"/>
        <property type="gene ID" value="STSP2_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02575"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16483" checksum="A0FD967D9330CF81" modified="2017-06-07" version="1">MVGLIGRKFNLSILTPGKSLMEGKVALLNIPAHDGMRGILYNHCPMLCQLGTGIMEVHEIAGEPDRYYLVEGGLARINENHVTILAYDATNLRDMELEEAKELVRKSRELVAGKGYIQHQKKTEITPEKARLLVHLAELDKFDETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG6</accession>
    <name>A0A1U9NPG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02802"/>
    <dbReference type="EnsemblBacteria" id="AQT69608">
        <property type="protein sequence ID" value="AQT69608"/>
        <property type="gene ID" value="STSP2_02802"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02802"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="674" mass="76942" checksum="2C35525AF9701F94" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH5</accession>
    <name>A0A1U9NPH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-binding protein Uup</fullName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">uup</name>
        <name evidence="9" type="ORF">STSP2_02701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Associates with ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02701"/>
    <dbReference type="EnsemblBacteria" id="AQT69510">
        <property type="protein sequence ID" value="AQT69510"/>
        <property type="gene ID" value="STSP2_02701"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02701"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00848">
        <property type="entry name" value="Uup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043686">
        <property type="entry name" value="Uup"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="320"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="633" mass="71782" checksum="FDDFEFEC78B9CB52" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK4</accession>
    <name>A0A1U9NPK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplW</name>
        <name evidence="6" type="ORF">STSP2_03049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03049"/>
    <dbReference type="EnsemblBacteria" id="AQT69851">
        <property type="protein sequence ID" value="AQT69851"/>
        <property type="gene ID" value="STSP2_03049"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03049"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10742" checksum="37ADC0762E260333" modified="2017-06-07" version="1">MDDHNIVIKPLVTEQSMHFAGKYNAYAFQVNRRANKTQVREAVQRLYGVKVVDVRTMNRKGKPRRRGRNIGSTSNWKKAVVVLHEDHHIDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK9</accession>
    <name>A0A1U9NPK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">STSP2_03047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03047"/>
    <dbReference type="EnsemblBacteria" id="AQT69849">
        <property type="protein sequence ID" value="AQT69849"/>
        <property type="gene ID" value="STSP2_03047"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03047"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9932" checksum="A2084D35E63B9276" modified="2017-06-07" version="1">MGRSQKKGPFVDEKLYYKVMKQVEAGTSEPIKTWARACTIIPEFVGFTFMVHNGKIFNKVFVTEDMVGHKLGEFSLTRTFRGHSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP3</accession>
    <name>A0A1U9NPP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsP</name>
        <name evidence="5" type="ORF">STSP2_03079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03079"/>
    <dbReference type="EnsemblBacteria" id="AQT69879">
        <property type="protein sequence ID" value="AQT69879"/>
        <property type="gene ID" value="STSP2_03079"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03079"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16351" checksum="26FCD835297DA805" modified="2017-06-07" version="1">MAVKLRLTRIGRRHRPFFRIHAIESRNPRDGRILEKIGHYDPIEKDEEKQIVIDLERAKYWIEKGAVPSDTVVDILAKKGVTTKIGEARKKRRQKALEIARKKGKPFTKAEKIAAEKAAEEAAEAAKAAAEAAAKAAKEAEEAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU0</accession>
    <name>A0A1U9NPU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SagB-type dehydrogenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69738">
        <property type="protein sequence ID" value="AQT69738"/>
        <property type="gene ID" value="STSP2_02934"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02934"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="27860" checksum="AC46726EB8D5D653" modified="2017-06-07" version="1">MHPIEKNRKFLRADDWKDLSEIASDQQKGVQAPPVEKPYDENAKLIDLTPADKLDIGHISLFDAIQNRKSHRRFKDEHISLNELSFLLWATQGVRRVTANGVTSFRNVPSAGSRHALETYLVIRKVEGLQAGLYRYLPVEHKLELIRTEKGIEGRLAQACCGQTFIATAAVSFVWTSVPYRMEWRYTVASPKLIALDAGHIAQNLYLAVEAINAGTCAIAAYFQDQVDHVIGLDGKDEFAVYIAPVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY4</accession>
    <name>A0A1U9NPY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02975"/>
    <dbReference type="EnsemblBacteria" id="AQT69778">
        <property type="protein sequence ID" value="AQT69778"/>
        <property type="gene ID" value="STSP2_02975"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02975"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160472" evidence="1">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="194"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="477" mass="51604" checksum="7D2B8357F46FFCA5" modified="2017-06-07" version="1" precursor="true">MSKHTFLSVVTSLFLLTTSTHATTLVVDKTGRGDYTSIQDAINNASDGDVVEVMPETYYEQINFYGRAITVTGTNPDDMGTVYGTVINGGTAGVNTVTFDSGEDRDSILQGITIENGERGIYCYYSDPLIRKCVIRYAKNNEAAGIQGSSASPTIENCEVRENAGYGISWCQGTIENCSIVENSSGGISDCHGLIRDCDISFNGSRGLIDCDGEINNCSVNQNALYGLSDCNGQIRNCEITQNRDQGLNYCRTAEVVNCLVTGNEGNGFYEFSGQIKNCTIVGNQYHGISMTTSNDYGPATIANCIITNNGSYGISNRYPERCPTTLKFNNIWANGLGNYNGLKPGATDTHHDPLFAVAGYWDENSWLEGDYHLQSEAGRWTENGWVNDSVTSSCVDAGDPSGGFYSEPEPNGDRINQGAYGGTELASKSPFGVDPWCTEFLAGDLNDDCQVDFTDLAVLAADWMKCNLEPASACWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ00</accession>
    <name>A0A1U9NQ00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tufA</name>
        <name evidence="7" type="synonym">tuf</name>
        <name evidence="10" type="ORF">STSP2_03066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03066"/>
    <dbReference type="EnsemblBacteria" id="AQT69867">
        <property type="protein sequence ID" value="AQT69867"/>
        <property type="gene ID" value="STSP2_03066"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03066"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="403" mass="44528" checksum="514996045C3B2BBD" modified="2017-06-07" version="1">MAKAVFERTKPHINIGTIGHIDHGKTTLTAAITMRLANRYGFASRKFDEIDNAPEEKERGITINTAHVEYETESRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAASDGPMPQTREHILLARQVNVPRIVVFMNKTDQVDDPELIELVEMELRELLDKYEFPGDEIPIIKGSALAAMECDGKDDEACKPIDELMDAVDDYIPVPERAVDQDFLMPVEDVFSIKGRGTVGTGRVERGMVHTGDEVEVVGLSDDVRKTTVTGVEMFNKTLDEGQAGDNVGLLLRGVEKKELLRGQVVAKPGSITPHTKFIAEVYVLKKEEGGRHTPFFPGYRPQFFFRTTDVTGAVTAIRSREGKEVEMCMPGDNIEMEVEIISKIAMEDGLRFAIREGGRTVGAGVVTKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ12</accession>
    <name>A0A1U9NQ12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump membrane transporter BepG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepG</name>
        <name evidence="6" type="ORF">STSP2_03224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70022">
        <property type="protein sequence ID" value="AQT70022"/>
        <property type="gene ID" value="STSP2_03224"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03224"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="332"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114243" checksum="58394A978039475C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ65</accession>
    <name>A0A1U9NQ65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translocation protein TolB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69874">
        <property type="protein sequence ID" value="AQT69874"/>
        <property type="gene ID" value="STSP2_03074"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03074"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364403" evidence="2">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="509" mass="57308" checksum="9D40CF674D3A7B49" modified="2017-06-07" version="1" precursor="true">MVTKHSIRIIILILAALNAVSANAATSLDRQPAIKPDYASITIPSNIAPMNFAIEEEAASFTVKITSGSDSKGFTVKTSTDTVNIPPAKWTNLLKKATGKNIYFEITAHESDGTTVKFKKITNHVATDPIDDYLAYRFMRPIYNGWAKIQIRQRDLTSFDDSRIIHGKKFGNACMNCHTFPNNEPDQMAMGIRGQYGVGTLLAMDGKVQKLGTKWGYTEWHPNRKIAAYSINKVRQFFHAVGMQVRDVVDLDSGIVYYDVDDQQIRTAPALTKPDRLETYPAWTPDGKWLYFCSAPILWEDRDTVPPKNFDKVQYDLRRVSYDAETDTWGEAETVLTAEETGKSVLIPKISSDGKYLVVCLTDYGCFPVYQPSSDLAIIDLDTGEWRKMPDTVNSEYSESWHSFSSNGRWLTFSSKRIGGLLTRTFFCHIDEQGNLSKAFILPQKDPHFYDSIIQTYSLPQLVKGPVQYSEKELVRAALSDEQIEASLPVTGATPKVKEGDDPWQQVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ87</accession>
    <name>A0A1U9NQ87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion system FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03305"/>
    <dbReference type="EnsemblBacteria" id="AQT70102">
        <property type="protein sequence ID" value="AQT70102"/>
        <property type="gene ID" value="STSP2_03305"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03305"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="297" mass="33383" checksum="BD1B74FA9C9906E4" modified="2017-06-07" version="1">MRLRITQDGRKLNELIFDSGPIYIGRHVGSQIFLPERGVSRKHAVIYEEDNGDWFVEDLDSSNKTFVNDNAVHKSPLNTGDTIGICGFKINVKLMELEKEPAKTPLQLDDTIAHKPASPSSEEIHAEIRNLHSKSAPMLKIPPKRLTELCKAIKCFERCDSIKNLHSEAMSILLSQLAGREAWVGLSDCHGDRFEIEGGRKVSSQRIGRDDLAALEYLEETLEKHHSILIPQLPRAAGGRVVRSVLIAPVLVERKCYGALYVNNSPMHEHYESEDLDYLTLLSVHIAVAVERICEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA1</accession>
    <name>A0A1U9NQA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase/HEAT repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03315"/>
    <dbReference type="EnsemblBacteria" id="AQT70111">
        <property type="protein sequence ID" value="AQT70111"/>
        <property type="gene ID" value="STSP2_03315"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03315"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="36956" checksum="7AC2F9ECA3936F9A" modified="2017-06-07" version="1" precursor="true">MRKLTYLTAVSMMVFLLGCEAEQVSTQNGNALREPVNIRELEPTAIRVVETSLSDENPRIRSHAIETVVKCNRREMMPMIIDRLEDESFPVRFAAAMGLGDANYSAAKESIRPLLKDQNPHVRLSAAYALSRMGEPNHEKLLVKTLKSPDKSLKANAVLLLGKTEKREYINDLYAVAQEPETSEQVIMQALEAIAMIGDKDVYRQLWPLLISKYADDRQIGIRAMGALGTSDAEDAIITMLEDEVTEVRLCAAEQLGRMGNRVGRPEVLDYLKDRQTDAYTISKRRADFTAALAIGRIGGSELTRFLPGLLESDWQHIRLNAAGSVLLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE8</accession>
    <name>A0A1U9NQE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">STSP2_03038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03038"/>
    <dbReference type="EnsemblBacteria" id="AQT69840">
        <property type="protein sequence ID" value="AQT69840"/>
        <property type="gene ID" value="STSP2_03038"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03038"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="61" mass="7129" checksum="C20CAED5CB513322" modified="2017-06-07" version="1">MSTTALENKARSKPKYRSRGYTRCQLCGRARAVYRKFKICRICFRKMANEGKIPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF6</accession>
    <name>A0A1U9NQF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69958">
        <property type="protein sequence ID" value="AQT69958"/>
        <property type="gene ID" value="STSP2_03158"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03158"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010767">
        <property type="entry name" value="Phage_CGC-2007_Cje0229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07087">
        <property type="entry name" value="DUF1353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20538" checksum="FB4367F8A57841EA" modified="2017-06-07" version="1">MSRQISYIPPIVELLDNGNIRLSRGWRVRAGDWSFIARQGFVSDGNSVPWLFRGLVPKFGRNTVAGIAHDWLYYSGEMINSSGRAVQISQRQADMIRLELCRWCSVPWWQRLVSYIGLRIGGWYAWRKHRKRRAGAERRAVTGQRNQASQPDNEDGATGAGRIVKEPAAGPSPRTKSQEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF9</accession>
    <name>A0A1U9NQF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">STSP2_03048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03048"/>
    <dbReference type="EnsemblBacteria" id="AQT69850">
        <property type="protein sequence ID" value="AQT69850"/>
        <property type="gene ID" value="STSP2_03048"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03048"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="31265" checksum="9A908B58D5FDB55F" modified="2017-06-07" version="1">MAIKVYKPTSPGRRNASVIDYRKELTTGKPEKTLCKRIKKTGGRNHHGKTTTRFRGGGARRIYRIIDFKRAKDSSAATVQTIEYDPNRNCFISLVQYEDGEKRYVLAPSRLQVGDKIESGDNVEPRVGNAMPLRRIPVGVEIHNIEMTAGQGGKLVRTAGGTARLVAKEGDWATVILPSGEMRMIRMECRATIGQLSNADYQNVRIGKAGRKRHMGRRPHVRGKAMNPVAHPMGGGEGRSNGGRHPCSPTGVPAKGGKTRKRNKPGSNRIIRRRKTNRGVQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG0</accession>
    <name>A0A1U9NQG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70017">
        <property type="protein sequence ID" value="AQT70017"/>
        <property type="gene ID" value="STSP2_03219"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24257" checksum="BF6380404535AB4D" modified="2017-06-07" version="1">MGGLEILATADGAMVNEVQIVPIDELWAQVAGMNWLTAIMAIAFGSVYLLYGWRIFKALAVIAFAMIGLYAGIMIGRELGSEMWGGVIGVAALGALSLPLMKYAISILGALAGAVLTGALWYAFDLPEMYLWAGALVGLVGGGMISFIVFKAAVMLFTSLGGSAILVMGLLALLNGYEVTTGHEEKLVYHYVHNVSWFLPAILLVPTIIGMFMQHRLIKKSPEWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG7</accession>
    <name>A0A1U9NQG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70171">
        <property type="protein sequence ID" value="AQT70171"/>
        <property type="gene ID" value="STSP2_03376"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03376"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28875" checksum="CD2985971ED6260C" modified="2017-06-07" version="1">MEKLKLYFGNGTSIGAPKVDGTSSISFYSESGDGWVKLHVNGDEKFKLSLPDAGVFKGLFDYKWLTKSASGEIVVEMCDGSKYKKSYKAEKKHYEKNGLKATYGVIENLGLHFVSLEASAKYLAYGNYTGSSKIKWVYGAGVWTNNISIFGDWYYNREAGDARGYLYNDRSPFGTSGNTSDNSNYHSEIKSMPGHWDPPSKPKWGVMAKLIHPTRGKWFVSGIRVSGPAELKVSARLGIGAAAGNGVGIKRKFAFSLPGFPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM1</accession>
    <name>A0A1U9NQM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ORF">STSP2_03415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03415"/>
    <dbReference type="EnsemblBacteria" id="AQT70209">
        <property type="protein sequence ID" value="AQT70209"/>
        <property type="gene ID" value="STSP2_03415"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03415"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
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    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42987" checksum="E8D7CB13E63C7C4C" modified="2017-06-07" version="1">MTTQETIQLFDKYVIANYGRLPRVIVKGEGNYLFDADGNKILDMFPGWAVSGIGHCHPRVVEAIRKQAGELLHIDNTFYNEKQGILASMLSERGFGGKCFFCNSGAEANEAAMKLARKYTAEGKYKFITTEGSFHGRTYATVTATAQPKYHEGFLPMLPGFEYVPFNDVEALQRAFSDEVAAVMVEPIQGEGGINVATPEFMHTIRELCDAHGAAMILDEVQTGMGRTGKWFGYQHFDVEPDIISMAKALGGGMAIGGIMAKPEVAKALVPGTHASTFGGNPIACAAGIAVIEAIEQDNLLQNAVQMGEYAIEKIEALKQKHEIIDHVRSKGLMIGIQLTGPGAAIVDKCLEKGLRINCTQQTVLRFMPSMTVTRDQLDTALEILDTVLTEGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN4</accession>
    <name>A0A1U9NQN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_03130"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4073" checksum="41E6A5FF438668D3" modified="2017-06-07" version="1">MDELVIIVAALLTVLNLCILFLDKKNEDEGQKRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>A0A1U9NQS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="16032" checksum="1218161FEFE8A41B" modified="2017-06-07" version="1">MKSFRKELWFETTKRRQLINITPDVEDCLEKSGIQEGFALVNAMHISASVFINDDESGLHHDFEVWLEKLAPEKPYSQYKHNGFEDNADAHLKRTIMGREVVVAITDGKLDFGPWEQIFYGEFDGKRKKRVLVKMIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR02</accession>
    <name>A0A1U9NR02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15149" checksum="7E2435EA2A07AB2E" modified="2017-06-07" version="1">MDKNDLYAHTQLGKTFRKYKLISIFVFIGACLLNPVIDELAFFIAGAAVVMHGALYHIDKKVRQQMVLAKDARLEKDKLEIYLEEQKCNVVADLEGDCVQKADIQGVEYVSINVPMIICEVDGCIQPANSVKEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR58</accession>
    <name>A0A1U9NR58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein-releasing system transmembrane protein LolE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lolE</name>
        <name evidence="9" type="ORF">STSP2_03473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03473"/>
    <dbReference type="EnsemblBacteria" id="AQT70267">
        <property type="protein sequence ID" value="AQT70267"/>
        <property type="gene ID" value="STSP2_03473"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03473"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="343"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="459" mass="50946" checksum="413D14D57D854EC4" modified="2017-06-07" version="1" precursor="true">MYKFLLARRYFVKRKSTALAVAAVALCVFMVVVVMTVMSGLVREFKEKNHRFFGDAIISSDSLVGFAHYENFLEELVEKDYVLQASPVIETVGILESQMSGSQSGMKIMGFDPARHAKVTAFEESLHYREDEPEMAFVPTYRPNQPGVVVGIDLLRSRQGKMGEYYHEPNPMHIKLNVSCFPLTARGNLARAGIGGGLVNTKAFYYSDDSHSGLVEQDGGYIYMSLDDLQALCGMDGTYPRIHSIFVKYAKGMDVETATARVKRLWDDYVANIAADAETSYEKRLAGLMDHVNVETWKQYRAAMIAPMEKEETMMTLVFLMLGFITVFIIFVVFYMMISSKSKDIGILKSMGVSSGGVLSVFLGLAGIVGTTGTAIGMAGGIALLVKVHAIEDWLFENYQWQLWDRSVYAIGEIPNQIEWQTMVFIAACSVAACLAGAAIPSMQAARRRIAEVLQVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR83</accession>
    <name>A0A1U9NR83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent hydrolase of the TIM-barrel fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03434"/>
    <dbReference type="EnsemblBacteria" id="AQT70228">
        <property type="protein sequence ID" value="AQT70228"/>
        <property type="gene ID" value="STSP2_03434"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03434"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30228" checksum="994AC042324D0168" modified="2017-06-07" version="1">MPSRIIDFHTHAFPDAVAERAMANLQSGATGVEAYLDGTVADLLRSMDAAGIEKSFICTIATRPGQFEGVLTWCDSIRSDRILPFPSLHPKDDDKPQKIQQIAREGFHGVKLHPFYQNFYANDPRMREIYDNICTSQLVLLLHCGYDIAFPRERRVDPAKIRDLAQNWPDLKLVAAHMGGWDAWDEVEQLILGRNIYMDISFTFRSLGVQKTADLIRRHGPQKVLFGTDSPWNDQSQELKLLRDTNLPQADLDLILSQNALRLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRI5</accession>
    <name>A0A1U9NRI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70230">
        <property type="protein sequence ID" value="AQT70230"/>
        <property type="gene ID" value="STSP2_03436"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03436"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="30832" checksum="CB79E2F7C427D803" modified="2017-06-07" version="1">MASFDYDALGQRIRKVDHKTTANTRIYYYNDNWQVLAEYDGSDNFKRYRKAFLKLLLNLRPEIFSAGKACKIGNSRNYGRFCTTQPDGKRAAAKQNEFQNDFPVYGNYIDEPLMTSDTATDLYYAHDHLYSTAALIDTAGNVVERYEYNAYGKATVYNADYTQSWQKPQKENPYLYTGRRLDILDGGSLKLQYSRHRYYDPQTGRFLQKDPLGIVPDANKNSPLAATRQYSDGMNLYNYTSASPITSTDPDGLIRKFICCKQWQIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRW4</accession>
    <name>A0A1U9NRW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-N-acetyl-D-glucosamine 6-dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.136</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">wbpA_2</name>
        <name evidence="6" type="ORF">STSP2_03546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.136" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03546"/>
    <dbReference type="EnsemblBacteria" id="AQT70340">
        <property type="protein sequence ID" value="AQT70340"/>
        <property type="gene ID" value="STSP2_03546"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03546"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047004">
        <property type="term" value="F:UDP-N-acetylglucosamine 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="5">
        <location>
            <begin position="366"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="53300" checksum="0934731A97DB2383" modified="2017-06-07" version="1" precursor="true">MAAKKKTTKKAAKKTAKKKTTKKAVKKTAKKTTRKKAAKKKTTSAKKSDVPLVGIVGMGYVGLPLAREFCLGGAKVLGFDVNPKTVSNLNKGKSPLKHIPSSDVKEMVDTKNFKVTEKMNQLGKPDALLIAVPTPLTENREPDMQFVEKTCETISKYLRKGQLVVLESTTYPGTTKELMLPILEKSGLKAGRDFHLAYSPEREDPGNKSFRTATIPKVVGGYDKKSLDMAVEIYKYAIDTLVPVKSCEAAEAAKILENTYRCVNIAMVNELKMLFDRMGIDVWEVIHAASTKPFGYKAFYPGPGLGGHCIPIDPFYLTWKARQYGMPTRFIELAGEINTDMPHYVVMRTLEALNDHKKSLKGSKVLVLGLAYKKDIDDVRESPSLELIELLREKGARVDYNDPYIPQTHKQRDYDLQMKSKKLTPKMLQKYDAVLISTDHSEYDYNWVVENSQLVIDTRNATEKVRKGRKKIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG32</accession>
    <name>A0A1U9NG32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66889">
        <property type="protein sequence ID" value="AQT66889"/>
        <property type="gene ID" value="STSP2_00027"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00027"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9647" checksum="59D5E1D5A438910F" modified="2017-06-07" version="1">MRIENTQNAAASIKNVDAAANQRKQTDSAKQDKDAVFDSRIKDTLGKLPKIERNSADRIQRAKAMIAAGKLESSTNINAAAANILKFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG51</accession>
    <name>A0A1U9NG51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66911">
        <property type="protein sequence ID" value="AQT66911"/>
        <property type="gene ID" value="STSP2_00049"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00049"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13669" checksum="DFC9F19FB936CC0E" modified="2017-06-07" version="1">MKPENANKTDDLRDIEPAQAVACLEKLLQDQLNHVHQDDDARSSRTTTEAAYVAEFIAENKVLERDEFNDSRQRILNLYRRISAAMFAQKEKTLRQLTKVSKGHKAVSKYNESTKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE6</accession>
    <name>A0A1U9NGE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Foldase protein PrsA 1</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prsA1_1</name>
        <name evidence="4" type="ORF">STSP2_00141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00141"/>
    <dbReference type="EnsemblBacteria" id="AQT67003">
        <property type="protein sequence ID" value="AQT67003"/>
        <property type="gene ID" value="STSP2_00141"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00141"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="146"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="33006" checksum="950A1C973896B62D" modified="2017-06-07" version="1">MALYVNGERVEEKEIQAEVERLKPDYQRVFGDQSPEEQYEQLYAWSKENVIERVLLRQAARAKVTDVDDETVEKAFENLVEQAGGKAELLSQAGLAPGSEDKVRQDIADRMKTEKLIEKITADVGEPTKKQIEKYYQKNLERFTIPEMIRASHIVLHPSPDVDRETQYKEMEETLSKLKKGEAFDTLAQQHSACPENGGDLGYFPRGQMVQSFEDVVFNMKVGETSEIFETEFGYHIAKVTDHKESTPCPLDDVREVIVKELTEQAKQKALEKFVDAQKERATIEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK2</accession>
    <name>A0A1U9NGK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">STSP2_00203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00203"/>
    <dbReference type="EnsemblBacteria" id="AQT67063">
        <property type="protein sequence ID" value="AQT67063"/>
        <property type="gene ID" value="STSP2_00203"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00203"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="44500" checksum="9D456D6FE225AA12" modified="2017-06-07" version="1">MNVLVIGSGGREHAIAWKLKQSKKLGRLFISPGNPGTAGVGINVDLDVNDHDAVVGWAKKNSVGLVVVGPEDPLADGLVDACEAGGIKAFGPSKAAAKLEADKVFAKEIMRANSIPTAESRTFTNFADAKSYIASRDEAVVIKAAGLAKGKGVIVCDEPSDGILAAEKIMVEKAFGEAGEKIIVEEKLLGEEASILAFVDGRNIFVMESSQDHKAVGEGDTGENTGGMGAYSPAPIVTDKVMDQIVREVLVPTVAGMARNGTPYKGVLYAGIMLTKGGPRVLEFNVRFGDPETQPIMMRMKGDLLEVMLAVCDGRLDEVDMGWDERPAICVVMASGGYPGPYVKGKEIGGLDDAGAMEDVVVFHAGTATAEGGSKIVTNGGRVLGVTALGDDLKAAQARAYAAVDKIAFEDAYCRRDIGWKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK3</accession>
    <name>A0A1U9NGK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC, inhibitor of MCP methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00025"/>
    <dbReference type="EnsemblBacteria" id="AQT66887">
        <property type="protein sequence ID" value="AQT66887"/>
        <property type="gene ID" value="STSP2_00025"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00025"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16914" checksum="1CFC3975AAA68D60" modified="2017-06-07" version="1">MIAETCYLEVLVDAAKEVFETMIFMTVDDNPEVDCVEGDALLGSITFKGELEGCMSICCGKDDATLIAATMLGMEPEDGLAEEDIRDAMGEIANMVMGSVKARLLENGLSNLDVSIPCVVSGKELSSSLGDSAVQIKKVVCIDECPAELMLLYRSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM1</accession>
    <name>A0A1U9NGM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_00219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00219"/>
    <dbReference type="EnsemblBacteria" id="AQT67079">
        <property type="protein sequence ID" value="AQT67079"/>
        <property type="gene ID" value="STSP2_00219"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00219"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="14237" checksum="43E55E8FBE4CD60B" modified="2017-06-07" version="1">MYAITIEQNFVATHAVTMPDGQQEKPHHHDWRVRVAVSSHDLDQNNMAIDFIDLKKKLTSILRPISNKILEQLTDFPDSGATAELVAKYIHDSLTQLLPSRVHLDYTEVMEEHNCWARYRPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN9</accession>
    <name>A0A1U9NGN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tol-pal system protein YbgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66927">
        <property type="protein sequence ID" value="AQT66927"/>
        <property type="gene ID" value="STSP2_00065"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00065"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="831" mass="92708" checksum="BEFC235B370FDB74" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGT5</accession>
    <name>A0A1U9NGT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol:disulfide interchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67139">
        <property type="protein sequence ID" value="AQT67139"/>
        <property type="gene ID" value="STSP2_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00280"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="231" mass="23852" checksum="3D1FC42D8BE0D4E0" modified="2017-06-07" version="1">MERLFTELTHAVEGVWWLGLTGAFLWGVVSIVLSPCHLASIPLVVGVISQQKDGGARRSLYISLVFSLGIMLTIGAVGAVTAMAGRLMGDVGPMGTYVVGAVFVVFGLVMMGVVNIPWLSSGQFGAGSGSLGAAFVLGLIFGIAVGPCTFAYMAPMLAVVFECASENAVYAVSLVMLYAVGHCGVIVGAGVSSDAVGRYLGWHERSQIGGVLKKAVGGIIVLCGLYLLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX1</accession>
    <name>A0A1U9NGX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid protease GlpG</fullName>
            <ecNumber evidence="7">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpG_1</name>
        <name evidence="7" type="ORF">STSP2_00195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00195"/>
    <dbReference type="EnsemblBacteria" id="AQT67055">
        <property type="protein sequence ID" value="AQT67055"/>
        <property type="gene ID" value="STSP2_00195"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00195"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="42740" checksum="AE5E0B2C7562D974" modified="2017-06-07" version="1">MNVLIFLVTYIGEHRAPTGEPEVLRAWANEFMLTPIRPQLWQFISYAFLHGSFMHIFGNMYFLYMFGNSVNDRLGNVGYLCFYLAGSIIAGLGHFAFSNSPVLGASGAVAAVTGAYLVLFPKSVITVIYWFFIIGTIEVPAFWFIGLKLIVIDNLIVQTAANVAYDAHLTGYAFGIISIYLLLVLHLQEHEPQDLAIVLKQWYRRRKYKSAVSQGFDPFSGSTETTKKVRAKTRDTKKAHQQKINDQQIKHLRGEIGKNVTERNLPEAARIYAELLELDPGHVMPRQYQLDIANQLMSECKWQLSAQAYEGFMKHYENAEYAEQVELMLGILYSRYLDKPALAAKYFKQAREKLHDPGQIRLCEAELAKLREKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY5</accession>
    <name>A0A1U9NGY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilE</name>
        <name evidence="2" type="ORF">STSP2_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67065">
        <property type="protein sequence ID" value="AQT67065"/>
        <property type="gene ID" value="STSP2_00205"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00205"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19168" checksum="6A15C8D7C42E0101" modified="2017-06-07" version="1">MKHTKTNANKTDKGFTLIELMIVVSILGIVSAIAFPTFKDHVAQAKEAAAKDNLRVLREAINRYAIQHKDVPPGYANSDPSNTPNELAFGFQMIKASTEDGALSNPGTAGYPYGPYLPEIPTNPFNGLSSVTVLTDTDSFPSPPPEDTGWIYKPLIKEIRLNTAGTDSQGKSFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH13</accession>
    <name>A0A1U9NH13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PBSX repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xre</name>
        <name evidence="3" type="ORF">STSP2_00366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00366"/>
    <dbReference type="EnsemblBacteria" id="AQT67223">
        <property type="protein sequence ID" value="AQT67223"/>
        <property type="gene ID" value="STSP2_00366"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00366"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="42144" checksum="AAEC772D0F32C809" modified="2017-06-07" version="1">MPNIAEKLKHLRISSGLTQKQVTDRTGIDDSRLSEYENGRSEPRLGILAKLADVYGVTLDSLFSAQIEPELRVLWRNEPQNKRDIQQEFLTYCRQYHQLEMWTNSKVEKKLPYPEISARRFHYQEVADLAAETRSLMGLGNRPGQTLFSILQEVYGVKIFHLDLEDAGIAACTVSEEFGPAIALNCNCPRWRRNHDIAHELFHILTWEHFGHSSEQLVLTDQEEKYATCFAGNLLMPEETVKAAVNKATDDSGKVSFNRLEMIAREFDVTLESLIWRLHYVYNFDLDETKSWIERSKNLVQKRARDKGEKPELFPERYKALAIGALLDGQISIGKFARFMQISRSAAKDYLSNESIDYAEMPVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH22</accession>
    <name>A0A1U9NH22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67232">
        <property type="protein sequence ID" value="AQT67232"/>
        <property type="gene ID" value="STSP2_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00375"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="26178" checksum="E846BC6686AD10EE" modified="2017-06-07" version="1">MFKWLRRQIEKGRPRPINIDPAQFNDPVAIKTGWEPAYDGPAGNVRIYTLVAQDAHKMVFTMSGASYLFWFVYFLAITSPLIFGLTSDNLKGAIPVIVIFAIPCILLISVGFWAFWYYSRPMVFDKRSGLYHRGKLKSTAYGKRQKKDEKAIPLDDIHALQIIPKLVRDESDYCYNYELNMVLKNGDRKNLLNVDRLKHVMPEANRLASFLEIPAWNAVTETEGDPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA0</accession>
    <name>A0A1U9NHA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent methanol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.244</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdh</name>
        <name evidence="3" type="ORF">STSP2_00265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.244" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00265"/>
    <dbReference type="EnsemblBacteria" id="AQT67124">
        <property type="protein sequence ID" value="AQT67124"/>
        <property type="gene ID" value="STSP2_00265"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00265"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050093">
        <property type="term" value="F:methanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="384" mass="40535" checksum="D8DB42E632CF46DC" modified="2017-06-07" version="1">MSGIGESIFKFVCPEVVFGVGSRGYAARYAFNTGMSSVLLVSDEGVFEAGWGREVVECLEEAGLHVAVYTDVTPNPKDYEVMKGVEIYQYAECDGIIAVGGGSVIDCAKGIGVVVSNGGDIKGYAGVDTIRKPGPPLICVPTTAGTGADVSQFAVITDSFTKEKMCLVSKTLVPDVSLVDPETTCTMDRGLTAATGMDAFAHAIEAIVSNGSSHLTELHATEAIKLIHTYFEKVCENRDDMEATVGMMLASTHAGMAFSNASLGLVHAMAHALAGVVDVSHGVCTAMVLPYVMDYNMAAAEDKYKLAAEAMGVDGDDAEWMEDMSVEVGKLLGNIGESSGLREAGVSEDDIGGMADKAMKDATIVTNPRKPTRQEVEMIYERAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI9</accession>
    <name>A0A1U9NHI9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glyA2</name>
        <name evidence="7" type="synonym">glyA</name>
        <name evidence="10" type="ORF">STSP2_00523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00523"/>
    <dbReference type="EnsemblBacteria" id="AQT67379">
        <property type="protein sequence ID" value="AQT67379"/>
        <property type="gene ID" value="STSP2_00523"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00523"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="418" mass="45955" checksum="80FCC8E59665C1C2" modified="2017-06-07" version="1">MYDRLKTHDPEIYNLLNEEETRQQDSIRLIPSENYVSMAVREATGSCMTNKYSEGYPGKRYYEGQQVTDKIENLAIERAKQVFGAEHACVQPYSGSVANVAVYTAFADPGDTILALSLPFGGHLTHGWKVSVTGKFFNAVHYTLEDDSDLIDYDQIEKLALECKPKVIVSGATAYSRHIDYARFNEIAKKVGAAHVCDMAHVAGLVAAGAHPNPVPHSDAVTTTTHKSLRGPRGALILCKEEHAAKINKAVFPGMQGGPHMHTISAIAVALREAATPEFKQYGQQVVKNAKRFAEKLVELGFDVVSGGTDNHLVLIDLRPKNILGKPLAKALDRAGIVTNYNTIPNDPAKPFNPSGIRMGTPAVTTRGFKEEQMEQIAEWINEITHNVENDEVIEKVHKQVKQLCDDFPVPANFVNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY4</accession>
    <name>A0A1U9NHY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67552">
        <property type="protein sequence ID" value="AQT67552"/>
        <property type="gene ID" value="STSP2_00700"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00700"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9756" checksum="48F935392B72086E" modified="2017-06-07" version="1">MEKHVFDMKLRELVAEMGSFAKKQGKCSEILARNTHRSKNLAGSKESVQDSLHNLTIGVKYLLFDLEATKRENEYLKKIIENSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI15</accession>
    <name>A0A1U9NI15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rnfB</name>
        <name evidence="9" type="ORF">STSP2_00508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00508"/>
    <dbReference type="EnsemblBacteria" id="AQT67364">
        <property type="protein sequence ID" value="AQT67364"/>
        <property type="gene ID" value="STSP2_00508"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00508"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S" evidence="8">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="278" mass="29575" checksum="3E5DB88B95992951" modified="2017-06-07" version="1">MLALGSVFALVLLIASIKLKVEVDPKIEQVHAALPGIDCGACGYAGCASYAEAVVNDPDELGKCSPGGPDCKSKIAAILNLQVSGGGAPQRPIVHCRAHYGDKTYYAKYQGVDSCTSANAVPNVQACRFGCLSFGDCTRACKFDALHIIDGLATVDYEKCTGCAACVKACPRDLIEMVPFSQENMLTVACSSQESGKDTRGMCKVGCIACRMCTKQSDLFEMTGNLARMKYEDYEPSEKTDTAEKKCPTNVIVYRGKTAPAPRAAGEKAQKPKPKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI55</accession>
    <name>A0A1U9NI55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">STSP2_00770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00770"/>
    <dbReference type="EnsemblBacteria" id="AQT67622">
        <property type="protein sequence ID" value="AQT67622"/>
        <property type="gene ID" value="STSP2_00770"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00770"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="29364" checksum="5A354DA479737ED8" modified="2017-06-07" version="1">MTDSFKQKRAAAAERLGVPAESIPRHIAIIMDGNGRWAQQRGLPRFHGHSKGGQIVEKIALYCVDIGVEALTLYSFSMQNWKRPAEEIEFLMGLYSMYLEGIRETLMKNDVRLVHLGREKPLPDKVIETMHGTVDLTKNNKGMALGLALNYGARTELIDAAREIAEEYKAGKLDIDDIDESCFDRHLYTAGLPDPDLLIRTSGEMRISNFLLWQLSYAEFYVTETFWPDFNPDSLDEAILAYAKRARRFGDVNSKSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC9</accession>
    <name>A0A1U9NIC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00831"/>
    <dbReference type="EnsemblBacteria" id="AQT67683">
        <property type="protein sequence ID" value="AQT67683"/>
        <property type="gene ID" value="STSP2_00831"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00831"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188770" description="TGc domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="494" mass="53679" checksum="CB5932AAD6E1DD81" modified="2017-06-07" version="1" precursor="true">MFKKTITFFLLLAICSTPMLAAQSETAPADEEKIYFAVLVDGNKIGHAAMTRLQQDDRVTHTTQMSMTMNRMGTDVGISMSIKTVETSDGKPLSFESSMNAGGFGQQTTGRVNEDGNFVAEITSMGRTEEKIIPLPEDALMDEGIALYVKQHDFEEGDTFTVKYFDPSMLQVVPMHNKLGPIEQIDLFGKVIDARKIYSTIQAPTGSITTENHVVGDDMMPVKVVTAMMGMKLELISCTKEFALSPNDTLDFMNKMLIKSPTRLTNLGDKTRAVYTIESLKKGDLWIPAGPGQSVMQKANGSLIVEVTKATPAGGTFPYTGDDETLLAALESSRYVQSEDETIKQLAQQATKDCETTAQAVKKIERFVHGYITAKDLSVGYASAAEVAQSKQGDCTEHAVLTTAMCRAVGIPSRVVTGLLYVDGLFGSEQVFGGHAWSEAYVNGQWVGLDATRKASRGCSVGRIILGRGDGEPGDFLNIQNTLGYFRITAAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF8</accession>
    <name>A0A1U9NIF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67701">
        <property type="protein sequence ID" value="AQT67701"/>
        <property type="gene ID" value="STSP2_00849"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00849"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="10776" checksum="E78BAD0F721F0509" modified="2017-06-07" version="1">MSLMHDIITTIGDAARLSSDMVKLKLEREAGTVKHALVQVVSFSAALFISTIIFLVGAAFLIFGGYLLLKMVVSPAAAALIMGGGLVLISGIILLMSKASVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK5</accession>
    <name>A0A1U9NIK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00900"/>
    <dbReference type="EnsemblBacteria" id="AQT67751">
        <property type="protein sequence ID" value="AQT67751"/>
        <property type="gene ID" value="STSP2_00900"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00900"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="355" mass="40532" checksum="A62C5426A86D8144" modified="2017-06-07" version="1">MIAVVTGMVGIDKKQYLEEVVRLANERGKQVTLCNVGDMMYAEAPDIAAGRILDIPLQRLRSLRRSIIKDIIAKARNGENIIINTHATFRWRHGLFRAFDFDQMRQLDADYYICMVDSVDALHVRLLAEHPINHTLKDLLVWREEETIATELMKEGVNEDAGYYILARGEDKTTIESCYRMIFEPERKKAYLSFPMTHVMDMPEVLEEIADFRGKMKESFTCFDPGDLEEAYLPYRAKRAAQSGQDFIELHALGRKVRLDLAEAINVEKDISSQTYTRDFALIDQSNMIISYIPHLGEGRAAISSGVERELQHAHEAGKEVYVIWPSPKDPSVFVTQTATKVFRSLDEAAGFFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ19</accession>
    <name>A0A1U9NJ19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH HARE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67932">
        <property type="protein sequence ID" value="AQT67932"/>
        <property type="gene ID" value="STSP2_01084"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01084"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="3">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17884" checksum="28C9F2AB1D405648" modified="2017-06-07" version="1">MKANQLKPGTICSCKVGSNTTQVKLLEAEPKGGWKVESLTSGKTMTIRNADRLEPADTAEKSSKADKSPASKTKGHTGGPKGSEAKRESKRLSLLDSAAVILEVISPLSCKDIVEKAIETNIWQPKSGKTPANTLYASILREINTKGDDSRFRRAQERGKFELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ62</accession>
    <name>A0A1U9NJ62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01127"/>
    <dbReference type="EnsemblBacteria" id="AQT67973">
        <property type="protein sequence ID" value="AQT67973"/>
        <property type="gene ID" value="STSP2_01127"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01127"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="24243" checksum="67F303EA398916C6" modified="2017-06-07" version="1">MYQNREDAGRRLALSLNRYKDEDCVVLGIAMGGMEIGYQVARYLDADFSPLMVRKLSYPKNPESGFGAIAEDGSIFIFPYVGRTLHYRTIDKIVEMEREEVQRRVDLLRDGEPLPDIRQKTVILVDDGIAKGGTIRAATMLCRKKGAQKLVIGTPVANAEMANDMADVGEDSVVLTTPKYFKAIPQVYRQWREVGDQEGLDIMEKWRSQLVHATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA6</accession>
    <name>A0A1U9NJA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01039"/>
    <dbReference type="EnsemblBacteria" id="AQT67887">
        <property type="protein sequence ID" value="AQT67887"/>
        <property type="gene ID" value="STSP2_01039"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01039"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011962307" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25853" checksum="67AB74A667C80355" modified="2017-06-07" version="1" precursor="true">MKMKSIAILCLLVIAPCASASVVGLWEFDDSADTTAATIGNDLSLVGSDTAMVGYDAQDGAVSIDVGSHYVADHGISPAAGEGYVNEWSLLIDFKYPALDWISLYQTNSSNTNDGDCFVRNGAATLGVSASGYSTNTTSTDTWYRMVVTADNDQFYRIFVDGQLWLDSSGQGQDGRFSLDPVLLLFADENGEDNEIHVSTAAIWDSALTADAVADMGAVGNAVPEPMTLSLLAIGGLAVIRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN4</accession>
    <name>A0A1U9NJN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68017">
        <property type="protein sequence ID" value="AQT68017"/>
        <property type="gene ID" value="STSP2_01171"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01171"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="311" mass="34995" checksum="E9DE4EA95F14AB30" modified="2017-06-07" version="1">MELFVGIDVSKYFFDVCCGVDGKVSHFDYNQQAVAECVKMLERVEPTLVVLESTGGYELQLALAVQDSGLPVVIVNPSRVRSFGRACGKIAKTDKIDARTIAWYASALRPQVRGRINRKMCKLKALTARRRQLVDMRTAERNRLEHVFEKAIRRSVEAVVKTIEREIGKVESAMAEHIDDDPQLREKVIKMRTVPAIGEVTASMIVSELPEIGSLNRRQIASLVGVAPMNRDSGLMRGKRTTGGGRKEVRTRLFMPTLVAIQHNPVIRKFYRRLLQNGKAKMTAVVACMRKLLTIINFMLAKNEEWKPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP0</accession>
    <name>A0A1U9NJP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68142">
        <property type="protein sequence ID" value="AQT68142"/>
        <property type="gene ID" value="STSP2_01297"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01297"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="72" mass="8406" checksum="17E66358A4E0A2D0" modified="2017-06-07" version="1" precursor="true">MLLNLFSGLTGISPGNLWMIPIAPAWLILELDRQHGWGYFDQDPINSFLLITTYWLIIGQLITWTIAYRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ4</accession>
    <name>A0A1U9NJQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-acyl-glycerophospho-ethanolamine acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01199"/>
    <dbReference type="EnsemblBacteria" id="AQT68045">
        <property type="protein sequence ID" value="AQT68045"/>
        <property type="gene ID" value="STSP2_01199"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01199"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="24718" checksum="0111AE360A0D92F8" modified="2017-06-07" version="1">MKTVLRYIWFQVLIKPLVLVVLGLNIRDRSRLHKHKQMILVANHNSHLDTMVLMSLFPFKRIQETRPVAATDYFYKSRLRRWFADNIIQIVPVQREIRSVRLDPLASCSQALKKGQSLILYPEGTRGEPEKLENFKTGIAHLSKRFPEIPVVPIFCHGLGKALPKGDFLLVPFYCDIFIGPPIYWQGNRNTFMKSLNQTMQGLAEQGNFKPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK95</accession>
    <name>A0A1U9NK95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein BaeR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">baeR</name>
        <name evidence="3" type="ORF">STSP2_01323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01323"/>
    <dbReference type="EnsemblBacteria" id="AQT68168">
        <property type="protein sequence ID" value="AQT68168"/>
        <property type="gene ID" value="STSP2_01323"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01323"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="71"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21343" checksum="7CC6EDD6369BF5AC" modified="2017-06-07" version="1">MGKMKNLFTTGEAAEICSLSQQTIIRCFDSGRLGGFRIPGSKFRRIPRESLVKFMKENDIPLDSIDTGKKKVLIVDDDTEIVELMVDVLTRDGRFDIKTASSGYDAGLLTQQFQPDVIILDYMLPDVNGNIVCQTIKRNPDFDDTRIIIVSGVVDEDEIQDLLDAGAESFMKKPFSIGELVERISSVLEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA6</accession>
    <name>A0A1U9NKA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase / nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01523"/>
    <dbReference type="EnsemblBacteria" id="AQT68363">
        <property type="protein sequence ID" value="AQT68363"/>
        <property type="gene ID" value="STSP2_01523"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01523"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="645" mass="72553" checksum="2D2B2B15E37A68D3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB1</accession>
    <name>A0A1U9NKB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">xcpT_5</name>
        <name evidence="12" type="ORF">STSP2_01329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68174">
        <property type="protein sequence ID" value="AQT68174"/>
        <property type="gene ID" value="STSP2_01329"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01329"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="11">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15027" checksum="4DA6DA47A3076142" modified="2017-06-07" version="1">MRRRKGFTLIEVLTVVLIIGLLAGFVVPKVINNLGDTKRSIAKSKMAQVEQAVTTFYVNCGRMPRDLDELLEAPSDVEEKWAGPYAKRSQLMDPWDNPYVYVEEGTVNQGSFDIISYGADGEPGGEDENEDIVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB7</accession>
    <name>A0A1U9NKB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01532"/>
    <dbReference type="EnsemblBacteria" id="AQT68372">
        <property type="protein sequence ID" value="AQT68372"/>
        <property type="gene ID" value="STSP2_01532"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01532"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="525" mass="58027" checksum="E95CFC75C98D1CC2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG3</accession>
    <name>A0A1U9NKG3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">xerC</name>
        <name evidence="15" type="ORF">STSP2_01463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01463"/>
    <dbReference type="EnsemblBacteria" id="AQT68305">
        <property type="protein sequence ID" value="AQT68305"/>
        <property type="gene ID" value="STSP2_01463"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01463"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011931">
        <property type="entry name" value="Recomb_XerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02224">
        <property type="entry name" value="recomb_XerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="142"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT68305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="335" mass="38036" checksum="EC46D43C2C1CFEE1" modified="2017-06-07" version="1">MKDCSLTQDFLDYLKFEKHFSDHTAKCYGADLVQYGQWLKPEQESSGSEGTAESGEWAGEGEVATATAVKPAVETSIKELTLTADTDVIRGYLAHLNQKGYSKSTTARKLATLRSFYKFLVRRNFIDSNPVTPVKTPKQEKKLPRFLEYEEVQRLLNAPSTKNWLGARDRAILEVLYSTGMRVSEIVSLNMDDVDFLGEVIHIRGKGKKERIAPIGSNALQAIQRYIEFRNRRMQNDSNFDAKVLFANKHGKRLSVRSVRRKMDKYLIEAGLDPDISPHTLRHSFATHMLNNGADLRSVQELLGHQSLSTTQVYTHLTTTRLKEIYDKAHPLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH1</accession>
    <name>A0A1U9NKH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68421">
        <property type="protein sequence ID" value="AQT68421"/>
        <property type="gene ID" value="STSP2_01581"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01581"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17101" checksum="72D61C20F3828E1B" modified="2017-06-07" version="1">MLYTSRKKSDASQCDLTPIIDIVFLLIIFFMIVCTFISAENFEVEIPDDIETAQDAQVDPPQTVTLTAMLEDGEVVYAVGSARISVPASGELLGSLTDQLDAQLAKLPEDKRLVDLRIDKDIPYKYCQNVLAAINRSSASKINIAVTKEKRFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ9</accession>
    <name>A0A1U9NKJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_1</name>
        <name evidence="5" type="ORF">STSP2_01627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01627"/>
    <dbReference type="EnsemblBacteria" id="AQT68463">
        <property type="protein sequence ID" value="AQT68463"/>
        <property type="gene ID" value="STSP2_01627"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01627"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="309" mass="34599" checksum="2F4B2D094A017144" modified="2017-06-07" version="1">MEVRVKNLKRYFGKTRAVDDISFSFSSGEIVGFVGPNGAGKTTTMKIMCTMDEPTDGDIFIDDTSVVQYPELARRKLGFMPDALPTHRDVSVDDYLDFFARSFGIKNHVRRKVVDDVEEFTNLLGIRDKFLKDLSKGMKQRVSLARAIIHDPHILVLDEPAAGLDPRARIELRELLKALAQQNKAILVSSHILSELAEICDSTVIIEKGKLLRAGRLDSFDTSDLPIKRIYMRSLDPVDEFYRTLLQLPKVQRAKVVGSGVELDLEGTDETISATVANLVGQGCKIVEVRTLKDNLEDIFMNITKGELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS5</accession>
    <name>A0A1U9NKS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-deoxystreptamine glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.284</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kanF</name>
        <name evidence="2" type="ORF">STSP2_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.284" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68328">
        <property type="protein sequence ID" value="AQT68328"/>
        <property type="gene ID" value="STSP2_01487"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01487"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102318">
        <property type="term" value="F:2-deoxystreptamine glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="386" mass="44118" checksum="E53FAC300AAE35E3" modified="2017-06-07" version="1">MHKVAVVYQILAHYREPIFRRLCEQDYGVEFTLFSDSKNTINSVKAIDSEIAKLPVEKGGLRWKFVKNMKLPHHFLWQRGVVKLAFSKKYDTIIYLGDAYYLSTWVSCFLAKITGKRTLMWTHGFLSEENGLKGYVRKHFYDLADGVLVYGDRAKNIMIKKGFDPKSIYVVYNSLDYEKQKSLRSSVGVQKCEALKKRLFPKSVEQPTIFFIGRLIKNKNLKLLLQVAKLLKNSGSEINILFIGDGPERGQLERVTLEYDLKENVCFYGECHEESELAPLIMMSDLCISPGSVGLTAMHALAYGKPVITHDNLDRQKPEVEAIQPGKNGDLFQEGNFEELCAKVESWLDRKVSSCECYDIIDKKYNPENQCRIIMNAIAEVSKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT0</accession>
    <name>A0A1U9NKT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT_1</name>
        <name evidence="3" type="ORF">STSP2_01684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01684"/>
    <dbReference type="EnsemblBacteria" id="AQT68519">
        <property type="protein sequence ID" value="AQT68519"/>
        <property type="gene ID" value="STSP2_01684"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01684"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="372" mass="41456" checksum="6F809C09C46190D5" modified="2017-06-07" version="1">MATVHIDRLLEACIKMGGSDLHIVTGRPPVLRIRGRLRSLDTKVMDPDDTSALMKSITPDKNQQELQETGSTDFGFAFGDKGRFRTAIFKQRSHISMVLRLIPYELLSFEQIGLPKVAAALCRRPRGLFLVTGPTGSGKSTTLASMIDYINTNLDVHIITVEEPIEYYHYHKKAIVNQREVGIDVTSFAEALKRALRQDPDVILVGELRDLETIEAAITAAETGHLVFGTLHTTGCQGTINRLIDAFPVSQQEQIRVQLSTNLIAVLSQTLCPLKGGKGRVAAYEFMLVTPAISNLIRENKTYRIESSIQTGKNVGMQLLDDHLWDLYAEDKIELQEMLDKARNPSELKEKADAKARREGKHLEDIRPIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW0</accession>
    <name>A0A1U9NKW0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpE</name>
        <name evidence="9" type="ORF">STSP2_01750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01750"/>
    <dbReference type="EnsemblBacteria" id="AQT68582">
        <property type="protein sequence ID" value="AQT68582"/>
        <property type="gene ID" value="STSP2_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01750"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005257">
        <property type="entry name" value="Anth_synth_I_TrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF22">
        <property type="entry name" value="PTHR11236:SF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="7">
        <location>
            <begin position="262"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="541" mass="60565" checksum="0F74769C54BA4BC9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX4</accession>
    <name>A0A1U9NKX4_9BACT</name>
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        </submittedName>
    </protein>
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        <name evidence="4" type="primary">nedA_4</name>
        <name evidence="4" type="ORF">STSP2_01538</name>
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    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1936003.STSP2_01538"/>
    <dbReference type="EnsemblBacteria" id="AQT68378">
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        <property type="gene ID" value="STSP2_01538"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160468" evidence="2">
        <location>
            <begin position="25"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="385"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="579"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="741" mass="82840" checksum="06C20DA209D39623" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX7</accession>
    <name>A0A1U9NKX7_9BACT</name>
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        <submittedName>
            <fullName evidence="8">Bifunctional protein aas</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aas</name>
        <name evidence="8" type="ORF">STSP2_01321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01321"/>
    <dbReference type="EnsemblBacteria" id="AQT68166">
        <property type="protein sequence ID" value="AQT68166"/>
        <property type="gene ID" value="STSP2_01321"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01321"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124266" checksum="B79887635A52BB39" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY2</accession>
    <name>A0A1U9NKY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH peroxidase</fullName>
            <ecNumber evidence="3">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbr2</name>
        <name evidence="3" type="ORF">STSP2_01770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.1" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01770"/>
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        <property type="protein sequence ID" value="AQT68602"/>
        <property type="gene ID" value="STSP2_01770"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01770"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
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        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
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        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL11</accession>
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    <protein>
        <submittedName>
            <fullName evidence="8">2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01789"/>
    <dbReference type="EnsemblBacteria" id="AQT68621">
        <property type="protein sequence ID" value="AQT68621"/>
        <property type="gene ID" value="STSP2_01789"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01789"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19699" checksum="14B48D909CE7251E" modified="2017-06-07" version="1">MLKSIKNILDKTLEVTVMVAVAVLVIDVLWQVFTRFVLGQSSSWTEELATFLLIWVALLGSAVALNRGAHLGIDYFVGKFQVRTRIKIEVVVFVLVAAFSILVMMLGGWQLVTRTLELGQKTSTFKNLKMGYVYLAVPISGFFLALYSVIGVIERVQELISGNVDESLHVSDSASEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL28</accession>
    <name>A0A1U9NL28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Demethylrebeccamycin-D-glucose O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.164</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rebM_2</name>
        <name evidence="2" type="ORF">STSP2_01372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.164" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68216">
        <property type="protein sequence ID" value="AQT68216"/>
        <property type="gene ID" value="STSP2_01372"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01372"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102082">
        <property type="term" value="F:demethylrebeccamycin--D-glucose O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29545" checksum="96820FE9DAF14F03" modified="2017-06-07" version="1">MKCNEEISVEDVQEVYSGAEMRLWELLMGEQIHVGGLESSMELAEKAGIQAGSRGVDLCCCTGAGMKFLVRMCGVESMVGIDVTEMMVAEARERAHQEGLAERLEFVHADACATGLADGMYDFVWGEDAWCYVKDKDTLIVEAVRLVRDGGEIAFTDWVEGAVAMNENEAERFLRFMKFANVQDVDGYAGLLEATGCEVEIAEDTGRFAGCCDLYIDSVRRQYMYDALKILGFDMDALGAVAEEMCFLRDMAKAGKICQALFVAKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL82</accession>
    <name>A0A1U9NL82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adhT</name>
        <name evidence="2" type="ORF">STSP2_01489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01489"/>
    <dbReference type="EnsemblBacteria" id="AQT68330">
        <property type="protein sequence ID" value="AQT68330"/>
        <property type="gene ID" value="STSP2_01489"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01489"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="710" mass="77192" checksum="B3506AE5584EE1A4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL93</accession>
    <name>A0A1U9NL93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cas5</name>
        <name evidence="3" type="ORF">STSP2_01884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01884"/>
    <dbReference type="EnsemblBacteria" id="AQT68712">
        <property type="protein sequence ID" value="AQT68712"/>
        <property type="gene ID" value="STSP2_01884"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01884"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="217" mass="25076" checksum="DAD76C8DEEBCBFF4" modified="2017-06-07" version="1">MGVKLKIWGDYACFTRPEMKVERVSYDVITPSAARGILEAIYWKPAIRWVVDRIHVLRPIRFMNVRRNELAGKVSPANVKKAMKDGKTPLLQFIESDRQQRAAMVLRNVGYVIEAHFEYASDEDRNDGKHLDIFNRRARDGQCFMQPYLGCREFPANFRLIEPDEPVPASELKGEQDLGFMLHDIDFADDMQPRFFRPTMVDGIIEVPPFKGSEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB7</accession>
    <name>A0A1U9NLB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretory pathway, component PulJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68528">
        <property type="protein sequence ID" value="AQT68528"/>
        <property type="gene ID" value="STSP2_01693"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01693"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="389" mass="41542" checksum="4FDC8777F7A88AA9" modified="2017-06-07" version="1">MRKGFTIIELMLAMALLLALLVGSGVVFSEAIKAHRAAKATSEVSSKLRAITQQLEADFRGLQETGEVAVAWQAVPLDHDGDGTTDEYVRLDRIMFFADGDFATYGTWRTDTTSTDGQMLNGNLARVCYALASDPGGNSAIDLMPQNRILARSQHLYTAMTVYDKNDNPVDFPDPSGGTLQGATVPFSVPNSFFEFDALTMSGWLNLTFSATGASDKSDLLAQIFAIDLMGSSGDEGGLIVSPNSTVDLFGNATPDGAPVGLHQLLSQGVSEFRVQAWSEVAQGWYPQIDPSGEWDFGDDYSDRFVDAGGSPLDPTLGISSADSPVVLYQPGGTYFTVSGAGAADASTGTLALQEAPGLGRALKFTFTIHDENGFFENGKRFSYIVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC2</accession>
    <name>A0A1U9NLC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01765"/>
    <dbReference type="EnsemblBacteria" id="AQT68597">
        <property type="protein sequence ID" value="AQT68597"/>
        <property type="gene ID" value="STSP2_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01765"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="32004" checksum="9F81F517746CF001" modified="2017-06-07" version="1">MGSHKLAYIETDDLTVMGYSVAGEETVVAVPQLDVCFDIGKAPDQVISIDNLLLTHGHMDHAAGIAYYLSHRKFCGQKPGTVLTPKNTVKPISTIVKAWGKLDGNEIPVYLVGVEDGDECEIKPNIFARAFATKHSRGAVGYSVIERRKKLKEEYLGLSGPEIVDLKKQGVTIDYTVEIPLVSYLGDTEYMDFAQLEHVRKSKILIAECTFLLEEHRERAHAGRHMHIDQFADLVERMDNQTIIVTHLTQRMGIGEAKKILRKRMSAESYKKTRLLMDRKFMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC5</accession>
    <name>A0A1U9NLC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68731">
        <property type="protein sequence ID" value="AQT68731"/>
        <property type="gene ID" value="STSP2_01903"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01903"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9913" checksum="A60A5BF93BAA2F5D" modified="2017-06-07" version="1">MYTNRKMQTRCNPAKAFLFRHLDEDAKDEIDKSLRSRSFPETNEEMLTLTSNSDRKLNRLLANTSKENLKRFEPSAANNENQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE0</accession>
    <name>A0A1U9NLE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">STSP2_01785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01785"/>
    <dbReference type="EnsemblBacteria" id="AQT68617">
        <property type="protein sequence ID" value="AQT68617"/>
        <property type="gene ID" value="STSP2_01785"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01785"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17659" checksum="15A0AAABD4F7CC38" modified="2017-06-07" version="1">MTSKVLTWPPRPYNPGKPALDRLFFRKHQRIKDNAEFRRILSRHCCAGRGFVRVYAWPSKTDTSRLGVSVSRRCGNAVNRNRLKRLARESFRLEQNNIPAPFDYLLIYAPKMSNRGSGACRDLSELTFGDIRCIFLDLARKSAEKAGIKAENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF5</accession>
    <name>A0A1U9NLF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">STSP2_01560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01560"/>
    <dbReference type="EnsemblBacteria" id="AQT68400">
        <property type="protein sequence ID" value="AQT68400"/>
        <property type="gene ID" value="STSP2_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01560"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="288"/>
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        <source>
            <dbReference type="Pfam" id="PF02749"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    <sequence length="290" mass="31748" checksum="04341D223674A0E0" modified="2017-06-07" version="1">MMHEIDLKAVGRLIDLAVDEDYADGDPTSEITVAEDAWGRAGIVSREKIVVCGMSIVGDILGRYSRKLGLQVLVNDGEEAGEGDLLGVIQGPTRSLLAAERVVLNFLQRLCGISTGTKEYVDAVKGTKAKILDTRKTTPGWRELEKYAVRCGGGVNHRMNLGDGVLIKDNHVTEFGDKIAEKLGPMVARARLYPRVKFVGVEVDDVDFQLKQVLAVEGIDVVLLDNMSYKEMRRAVEMRNEMCGERPLLEASGNIRLENVREVAETGVERISVGALTHSAVSVDIGLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH3</accession>
    <name>A0A1U9NLH3_9BACT</name>
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        <submittedName>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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    </reference>
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            <begin position="500"/>
            <end position="528"/>
        </location>
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        </location>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68614.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="528" mass="58142" checksum="CD19F0E522B2CF41" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR0</accession>
    <name>A0A1U9NLR0_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
    <sequence length="350" mass="39661" checksum="A77556330DE9BD7A" modified="2017-06-07" version="1">MSKLRQIIFWLVLTVIAVLIGCSVYGAFIGADRAEIFFNSLPLASFWVLFLLLLAAGFAVFPALWRKPALLLCHLGPILVLIGGLWGSQTAHELRREFGLADKLYKGKIAVLEGEAVNEALLPPEYEESFELPFSLRLKDFRIEYYPIGSLVIQSRPTETRPTKTWNLPAEIGKTYSLTDGETVEIVKVYRNFKITIEDGQVQPKDVPGPAQNPAVEVILRDEEGNEMRKYAFQNFPGHIKPEDQYALRYNRNIKDFISEADILVDGEVQKQAEIEVNHPLYYDGYHLYQSEYRQVGPGSYMSILSVVSDRGLYFVWAGYAALCLGIVWQLWFVKLVSKISRRRGGNSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS6</accession>
    <name>A0A1U9NLS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68785">
        <property type="protein sequence ID" value="AQT68785"/>
        <property type="gene ID" value="STSP2_01958"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01958"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="148" mass="17111" checksum="D298A82ADF025388" modified="2017-06-07" version="1">MTDLQMLHARLEDLAYHVTEPFCYGCYIKVEGENCPRCGSDDLMRHLEGVGVEYGTEWIIESLIENNCEPINEEEAYSELLDEIYGEVQFDGIVFYPSDIIRELDPVAFRCGCNDYLAAEESDGQLYEVNGRYYRLYDIEEMIADLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS7</accession>
    <name>A0A1U9NLS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase (URO-D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68757">
        <property type="protein sequence ID" value="AQT68757"/>
        <property type="gene ID" value="STSP2_01929"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01929"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="41739" checksum="E174E18A1791C019" modified="2017-06-07" version="1">MTPRERVLAILNGQQPDKVPWFGDLDYWATSKIHKGEQPKDFKVSESYIDWHRDLGVGFYLQGYFPFKTIIENCEIKNWHEGHKRYREIRTPKGVLRECWTWLEETCSEGPTEYLVKSVEDLPAYQFVHENTLYEPDYAFAETRLQQIGDQGLFLAYLPKSPLMQMVALDAGIVAVMNILMEDQDALGQTIQAIKKSHDKAAAVALECPAEILMMPENLSAEVVGPYLFNQYMKPYQQEWAAKINESGRFSCIHMDGTLKGLLREECTVGLTFIEAMTPAPVGDLAVEDWEEFTGDKETIFWGGIPGVYFTPSISDEEFDKFVIHVLSVMRSKPRFVLGVADQVPPDGLESRVKHVSELVEEYGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT8</accession>
    <name>A0A1U9NLT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoIID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02045"/>
    <dbReference type="EnsemblBacteria" id="AQT68869">
        <property type="protein sequence ID" value="AQT68869"/>
        <property type="gene ID" value="STSP2_02045"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02045"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459822" description="SpoIID domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="417" mass="45318" checksum="B41CB181851974B7" modified="2017-06-07" version="1">MRVDLRNIFASKSFTAWAVCSLAFLCAVLGSCQKRTTVEPKVVPAEARDLNIRVLLKNNADSAKLSTAGGFDVACTDGTSAHFTPGEVDIVPWNGMIRLGRHSFAGDVDLQVKDTFVTIDGRKYRGDVRIIIDARGGLDVINELDVENYLAGVVGEEMPAYWEPEALKAQAVAARTYCLYIKHRFGTDRQWDVKATEANQMYGGLESESAMVRTALDATAGQVLTCDNGDGPGGIFPTYYSSTCGGHTEDSKNVFGDSYKPLSGVDCQYCKKTAGEKYMNWKPVVLPSSVVTAKITSGYSSLEGLTTVDKIVPTRVSDYGSTGRIAMLKVVDNKGKTGILRGEDLRLTLDPSGKVLKSTWCNISKQPDGSFKFSNGRGFGHGVGMCQYGALGMAREGFGYKEVLSYYYPNSDLVKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY0</accession>
    <name>A0A1U9NLY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycogen debranching enzyme, archaeal type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01758"/>
    <dbReference type="EnsemblBacteria" id="AQT68590">
        <property type="protein sequence ID" value="AQT68590"/>
        <property type="gene ID" value="STSP2_01758"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01758"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006451">
        <property type="entry name" value="Glycogen_debranch_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024742">
        <property type="entry name" value="Glycogen_debranch_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="PTHR10569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12439">
        <property type="entry name" value="GDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01561">
        <property type="entry name" value="gde_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GDE_C" evidence="1">
        <location>
            <begin position="296"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="674" mass="76194" checksum="738A59AB10331CC3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY6</accession>
    <name>A0A1U9NLY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycothiol conjugate amidase Mca</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01920"/>
    <dbReference type="EnsemblBacteria" id="AQT68748">
        <property type="protein sequence ID" value="AQT68748"/>
        <property type="gene ID" value="STSP2_01920"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01920"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346507" evidence="2">
        <location>
            <begin position="24"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="92"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="744" mass="81069" checksum="25B769C2C3CA596B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY9</accession>
    <name>A0A1U9NLY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-4-deoxychorismate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.99.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sgcG_2</name>
        <name evidence="2" type="ORF">STSP2_01768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.24" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01768"/>
    <dbReference type="EnsemblBacteria" id="AQT68600">
        <property type="protein sequence ID" value="AQT68600"/>
        <property type="gene ID" value="STSP2_01768"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01768"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21976" checksum="9AF179DF52D02EF4" modified="2017-06-07" version="1">MGKKVIGIVGSYRENGTIDAAVSAALEGAQKAGAQTEKIFLPNKKIAFCRNCRICTQDENVWPRGSCPIDDDMNDILSKIDAADGLILGSPVNFGTTTAIMKSFIERLVAYAFWPWGKAAPSNRIDKPTKKAVVISSSAAPSILTRLFMRNASTTMRMAAKVVGAKVTRTIYFGMVARTEDWRLDDKRIAQCRRAGSILVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM54</accession>
    <name>A0A1U9NM54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folK</name>
        <name evidence="10" type="ORF">STSP2_02189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
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        <property type="protein sequence ID" value="AQT69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02189"/>
    <dbReference type="EnsemblBacteria" id="AQT69011">
        <property type="protein sequence ID" value="AQT69011"/>
        <property type="gene ID" value="STSP2_02189"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02189"/>
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        <property type="reaction ID" value="UER00155"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="dNK" evidence="9">
        <location>
            <begin position="164"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="39968" checksum="1CB12F425E1034F7" modified="2017-06-07" version="1">MAAYVGLGGNLGDTAVKIRQALQKLDSADTHVVRISSIYETAPLANKDQPSYLNAVAEVRTTLTPQQLFGRLVSIENSLGRARNGRWESRTIDLDLLMHGDQIFESPGLIVPHPQMHLRTFVLKGMCEIAAELRHPTTGRTMQELADRLNGHDFWLDPDRPQLISVAGVIGVGKTTLATKLADKLGCGVLREAYDTNPYLPAACKGDREAALKSQLYFLESRYEQLNADTLPSGKVVLSDYVFAKDSLFAERTLDADQLNEYNTRHAQVERAISEPVLTIYLKDTPARILERVQQRSRPYESSINENSIAELGGDYDEMFADWAHSPLITLDAAQFNCMQNDHVSELASEIRCYICER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM81</accession>
    <name>A0A1U9NM81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Potassium/proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68616">
        <property type="protein sequence ID" value="AQT68616"/>
        <property type="gene ID" value="STSP2_01784"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01784"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="425"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="555" mass="59415" checksum="BAC17C04AF9D46AD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM95</accession>
    <name>A0A1U9NM95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease 3</fullName>
            <ecNumber evidence="5">3.4.24.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrA_1</name>
        <name evidence="5" type="ORF">STSP2_02132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.55" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02132"/>
    <dbReference type="EnsemblBacteria" id="AQT68955">
        <property type="protein sequence ID" value="AQT68955"/>
        <property type="gene ID" value="STSP2_02132"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02132"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="166"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="45742" checksum="C2B1F409656B04E8" modified="2017-06-07" version="1">MEFKKTTLDNGLTIIGEVNPAAQSSAVGFFTRTGSRDENAQINGVSHFLEHMMFKGTDKLSALEVNKAFDRLGAKFNAFTSEESTVYYAAVLPEYLQDVTDLWSQLMRPSLRDDDFEMEKNVIKEEIAMYKDMPQFDVVDKCRELHFGVHPCGHSVLGTNESIDAMTAEQMREYFARRYAPDNMVVSVCGNIDFDAVADLVAQKCGHWQPSNAGREPTWFSGTGECRVEENENLMRAHICLMSPAVSMQDEKRFAASLLGTIIGDTTGSRYFWRLVDNALAETAVVHLDSMDGVGVYYSYVQCDKANVNKVLDIIRDVLAEVHRDGVTQAELDKARNKLLSSMAIRSEQPMGRLVGLGFNWMYLQEYRSLADDVEAIRGVTLQDIDALLAEHSLSEFTQYVLTPPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB3</accession>
    <name>A0A1U9NMB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">STSP2_02044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02044"/>
    <dbReference type="EnsemblBacteria" id="AQT68868">
        <property type="protein sequence ID" value="AQT68868"/>
        <property type="gene ID" value="STSP2_02044"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02044"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="380" mass="41793" checksum="363B002413EFB523" modified="2017-06-07" version="1">MSVFEVLTNDNGSSARRGRLQTAHGTIETPVFMPVGTRGSVKGLTPLQLKDTGSSIVLANTYHMMIRPGAEIVDALGDLHGLMGWDGPILTDSGGYQVFSLSTLNRVGDDGVEFASHIDGRKIYMDAEIATTVQNQLGADIIMCFDECTPFPAKREQIQVAVDRTIRWAEICKKTHSRDDQLLFGIVQGGVDPEMRSLCAEELIKLDFPGYAIGGLSVGEGHENMIRTTQHTAALLPSDKPRYLMGVGMPVDIVAAVHAGVDMFDCVLPTRNGRNAFAFTKNGPIRMRNSMHAQDTGPIDPDCPCYCCRNFGRGTLRHFFNVGEMLGPILVTIHNIVFYQRLMAEIRERIEAGTFSYWALESIELTNALESESISEYKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD1</accession>
    <name>A0A1U9NMD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68888">
        <property type="protein sequence ID" value="AQT68888"/>
        <property type="gene ID" value="STSP2_02065"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02065"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="40686" checksum="B784BCAED2926374" modified="2017-06-07" version="1">MIEFECNKCGKQLRVKDESAGKKGKCPRCRCILEVPAPDFDELIDESPVQRPVEERFPVTHKDATGNAVVRQKPHESGHSPNAPSVNVNMPKRTSSLGVVSLIMGILAFLICWIPLLGLLSIPVSSLGVLFAVIGFLIAIFRKGSGIGWPIGGGVVSALALIIAFTQVAVIGGAAEAIDEAAAKADQTKQEVVTSSGSGNSTSNNSEEANVTNTNNSEEAEEWVSAKYPVRQGDMQLQVKGAVKGKVPLIDSFDESQGSSRDDLLAIYLELINGSQSKKIEYQSWQGQDISFSRDYATLEDNFGNRYKRISFGFGTEIVGNAKSDSIYPGKSLIDVLVFELPVDTAEHLKLELPADNFGGEGMLRLQIPQDMIQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML6</accession>
    <name>A0A1U9NML6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02340"/>
    <dbReference type="EnsemblBacteria" id="AQT69153">
        <property type="protein sequence ID" value="AQT69153"/>
        <property type="gene ID" value="STSP2_02340"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02340"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18078" checksum="85C5023733BCC466" modified="2017-06-07" version="1">MDWWLLLAIFLYLVSAALFVAEVFVPSGGIISIFALTALGGGVALFFRHSTEAGIGGVVLAIVLIPATLIFAYKQFPKTKFGKSVTLQPPTRDRGDAVPDGDRLSKLTGQTGIVLSAMRPVGQCEFDGKRIECVADRAYVPKGKKVKVIRVQGMKVTVRPIESEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT3</accession>
    <name>A0A1U9NMT3_9BACT</name>
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        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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            <taxon>Anaerohalosphaera</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69231">
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        <property type="gene ID" value="STSP2_02420"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02420"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="9026" checksum="2879D8258D0A7BDD" modified="2017-06-07" version="1">MIKFKCSKCSTSLKAPDEYAGKKVRCNKCKKVIAIPSNGEKKKRDIVAVDPNHDSRAEFDSLLEELSRWEKKAPAADLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN36</accession>
    <name>A0A1U9NN36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69020">
        <property type="protein sequence ID" value="AQT69020"/>
        <property type="gene ID" value="STSP2_02198"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02198"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="22101" checksum="800F5FB8E3BA8A10" modified="2017-06-07" version="1">MPENDEFITIVSGLPRSGTSMMMQALEAGGIPILTDHIRSADVDNPRGYYEFEAVKKTKEDPSWLQQAPGKAVKMIYRLLYDLPEDRNYHVIFMDRPLEEVIASQKKMLERLGKKGGGIPDEAMIKAFEKELAAFDSWISTKKNFSVLHIEHRKMIEQPLEQCRLIADFLDGRVDPQKMAEVVDPTLHRNVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN47</accession>
    <name>A0A1U9NN47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69227">
        <property type="protein sequence ID" value="AQT69227"/>
        <property type="gene ID" value="STSP2_02416"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02416"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013069831" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20950" checksum="1A3E7E5B01A16CB6" modified="2017-06-07" version="1" precursor="true">MKKVLFSFLILTFSTLLVGCSASSRTQVPVEPLCGISQTKAHAMQVAEEVLTDMRFEIDKLDTEEGVIITQPLRGGQFFEFWRSDNATAQAAANSNLHSLLRQATLTFNETASGLCVDASVQTQRMVIADKPIAGMARLPRYYTGGDARLQELSVSEAQAEWEEMGHDPALASDILDRIQNKILELEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN73</accession>
    <name>A0A1U9NN73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69178">
        <property type="protein sequence ID" value="AQT69178"/>
        <property type="gene ID" value="STSP2_02365"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02365"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="386" mass="43629" checksum="D268FC19B99556CA" modified="2017-06-07" version="1">MNARENLLSIFRRQGFDYVPSQFYLCPSLCEVFKQRTGSDLSYQDYFELPMREVEFPSVAAQQSIDWGRFYGQEFKNTVTFDEWGIAHESGSKAAAHMTRMHHPMASFDSLEQIQSYPYPDFAAADTTELKKKIDSVHSRGLAVYAAMECTIWETAWYLRDMTRLMMDMAMEDEKAVWLLDKITELACVRTSTFARLGADVIRVGDDVGMQSSLMMSEDFYRSFLKPRLARVIKAAKDIKPDIIIQYHTCGYVTPLINDFIEAGIDVLNPVQPECMSFKELHSEFGDRLSFSGTVGTQTTMPFGTPEEVKKVTLQNLEIAGEKGGLLCCPTHLLEPEVPWENIVAYAQACQEFAKGSNVFQIAKSRRVIGTNPVTKGATGVRAKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN75</accession>
    <name>A0A1U9NN75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69402">
        <property type="protein sequence ID" value="AQT69402"/>
        <property type="gene ID" value="STSP2_02591"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02591"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="45" mass="5082" checksum="4E84B0B911EF5A51" modified="2017-06-07" version="1">MRPACFFCHFAVSIALRLPIIYNVSANSLITGENYEEESSCRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN86</accession>
    <name>A0A1U9NN86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yugI</name>
        <name evidence="3" type="ORF">STSP2_02601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02601"/>
    <dbReference type="EnsemblBacteria" id="AQT69412">
        <property type="protein sequence ID" value="AQT69412"/>
        <property type="gene ID" value="STSP2_02601"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02601"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="766" mass="84902" checksum="B367E782E8C96CDC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH6</accession>
    <name>A0A1U9NNH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N, N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.290</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pglA</name>
        <name evidence="2" type="ORF">STSP2_02639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.290" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69449">
        <property type="protein sequence ID" value="AQT69449"/>
        <property type="gene ID" value="STSP2_02639"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02639"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102335">
        <property type="term" value="F:N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="367" mass="40920" checksum="7633080F1F000F32" modified="2017-06-07" version="1">MKAANDQRLAIAFLLPGRGYSGGVRAGVRMAAEMQKRGHIVKLFYKNKRTPLRRCVKGLKNIIQRTPSDWVGNYAGTVQGFTTLNDQMLDWADIAISVGPDCTEDLETLDNENIVKIFHVHGLTLRNPHLKETAWKSPLLKIAVSDYVKRELNSAGAKPIAGVIGNGIDTSEYYPEPCDQRNGIGTVYGQGVAKSPDTICRTFGLLYENLARQCEFFCFGSCPRPRDLPKFVQYHRLPTIAQARRIYSQCSTWFCASRSEGFAMPLLEAMACGCSVVTFDCGGCRDFIKDGENGLILPEANAEKLAATITRLIYDVPLNNYLAQNAADTASQWTWHEVAKNMETLLWKIVSHQPKEQPVNNPFYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ9</accession>
    <name>A0A1U9NNJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69308">
        <property type="protein sequence ID" value="AQT69308"/>
        <property type="gene ID" value="STSP2_02497"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02497"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="110" mass="12774" checksum="02E7CD0EECD16E81" modified="2017-06-07" version="1">MVYRWGENGVKVGEKRQAVSYLSSGRLERESFHQEGHEGARRKGWRGALSIMIIMINTGWGFDVFAMKYLESVYVFFFFSFWCVRVVREGLWALLCICTVRVFLGVHADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL5</accession>
    <name>A0A1U9NNL5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">STSP2_02576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02576"/>
    <dbReference type="EnsemblBacteria" id="AQT69387">
        <property type="protein sequence ID" value="AQT69387"/>
        <property type="gene ID" value="STSP2_02576"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02576"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="145"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="473" mass="51048" checksum="5567B5FDD1216B8C" modified="2017-06-07" version="1">MSKGRIVQILGSIFDAEFAGDVPAIYNAVKIPGPLADGRKELVGEVQQHLGDGRVRIIALGSTQGLRRGMQVDDTGSSLKVPVGKETLGRVFNLLGDPVDGGAPVRSKEKWPIHREPPKFVELSAKSEVFETGVKVVDLLCPFVKGGKTGLFGGAGVGKTVMIQELIARIATEHGGYSVFAGVGERTREGNDLWLEMQETQIGDTGTSVLENTCLVFGQMNEPPGARLRVPLTALTMAEYLCEMSGAETLLFIDNIFRFSQAGSEVSALLGRIPSAVGYQPTLATEMGQLQERIASTAKGAITSVQAVYVPADDLTDPAPATTFTHLDSSVVLSRSIAEKGIYPAVDPLASSSRILDPNVVGKEHYDVAQQVLEYLQRYHDLQDIIAILGVDELGKSDQLAVSRARRLERFFSQPFTVTMQFTGMEGKYVSAADTVRSCKEICEGKWDHLPEQSFMYVGVVEEAAQQAAQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM4</accession>
    <name>A0A1U9NNM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulation protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nreC_2</name>
        <name evidence="5" type="ORF">STSP2_02625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69435">
        <property type="protein sequence ID" value="AQT69435"/>
        <property type="gene ID" value="STSP2_02625"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02625"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26437" checksum="5865607A07728C80" modified="2017-06-07" version="1">MNQHVKATDVKKARILLVDDHPIVRQGLSELINHEDDMVVCGHAEESYEAMSFIRNETLDMVIVDISLRETSGMELIKDIRAQRPHMPILTLSMHDESLYAERALRAGANGYVMKQEATDVLVGAIRKVMDGELHLSDNMAARMVRKLVGGKMKVESSPIDRLSDRELEVFRLTGQGLGTRHIAERLHLSIKTIETYRAHIKEKLSLGDAAELLQYAIQWVNSEVMSQPPETRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP10</accession>
    <name>A0A1U9NP10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69458">
        <property type="protein sequence ID" value="AQT69458"/>
        <property type="gene ID" value="STSP2_02648"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02648"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="305" mass="34196" checksum="A5599C3B506C189E" modified="2017-06-07" version="1">MDRVILGDNQFFGVSHLSEEKGMERARRFQNIDEIIKVIDYAYSAGIRGFSFSTHAQVEIICDYFRDNQHKYPGIRFYPCVPYAHKYANMVNEQGILGAVSEVVLSDNSASNAFGMMAKAGNFVFTQHPRRIMELLLDAEMKMFRDLNVEVVFLQNIITDLLLGLGWADVFCDFIDYIENNYNARAGFMTLNMPRLLHLLKSNGVESPVICSAINKKGFQMNPGLEAYETALTHESFEPVAMSVLAAGALRPTEAIDYISGFKSIKSVIFGASTPAHITATKELIESAFSQEQRTQPVVAYQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP59</accession>
    <name>A0A1U9NP59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Tyrosine-protein kinase YwqD</fullName>
            <ecNumber evidence="19">2.7.10.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ywqD_2</name>
        <name evidence="19" type="ORF">STSP2_02896</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="19"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02896"/>
    <dbReference type="EnsemblBacteria" id="AQT69701">
        <property type="protein sequence ID" value="AQT69701"/>
        <property type="gene ID" value="STSP2_02896"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02896"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="18">
        <location>
            <begin position="534"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="195"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AQT69701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="740" mass="82961" checksum="018F0044151BF424" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP67</accession>
    <name>A0A1U9NP67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02725"/>
    <dbReference type="EnsemblBacteria" id="AQT69534">
        <property type="protein sequence ID" value="AQT69534"/>
        <property type="gene ID" value="STSP2_02725"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02725"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="26168" checksum="DA05AF972736B4BC" modified="2017-06-07" version="1">MVKLVIFDMDDTLYDEVDYCRSGFNAAARYLSKKSHLPDSVSVQAIADELWHQFTAGNTTRTFNAALDKFDLPYDMDLIKRLITAYREHKPRINLPYDSKMTLDTLSQQYDLALLTDGFLPAQRLKVKALDIEKYFKCIVFTEEMGREYWKPHPAGFEKILKKLAVEPCNAVYFADNVAKDFIAPNKLGMSSIRLIRPNGVHHGEPASPEAAPDHTITDIKDLPGLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI6</accession>
    <name>A0A1U9NPI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferases group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69628">
        <property type="protein sequence ID" value="AQT69628"/>
        <property type="gene ID" value="STSP2_02822"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02822"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="368" mass="41762" checksum="368E9C0A48AE7E5D" modified="2017-06-07" version="1">MNEPIEVCFVSPKSYCLFNHDAKGCIGGAEVDLYYLGTEMARDDDFKVSFVAADFGQAEEESWEGIRVLKSLDFSQNSLAGAMKVWRALKRADADVYVIKTASPGVPLVRFFCLLYGRKFVYRTAHRFECDGTYLRKHTFLGRAFIWALRHADRIFAQNDADAEELRKTTGLESAVVPNGHRMLGVKPGEKEFVLWVGRSIGFKQPRKFFELARRFGTVRFVMICQRATGDTGYAELKAEADEIENLEFVEQVPFHEIEGYFARAKVLVNTSEAEGFPNTFIQACKCSTAILSLNVDPDGFLSEHGCGVSCGGNEKLMAEELGRLLDGEEYLEYGRKGRKYVEEHHDVRKIVEVYKDIFRRLIRSNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ6</accession>
    <name>A0A1U9NPQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric oxide reductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fprA</name>
        <name evidence="3" type="ORF">STSP2_02687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02687"/>
    <dbReference type="EnsemblBacteria" id="AQT69496">
        <property type="protein sequence ID" value="AQT69496"/>
        <property type="gene ID" value="STSP2_02687"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02687"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="44039" checksum="F3B1178C11234622" modified="2017-06-07" version="1">MRKIADNIYSVGAIDWDRRLFDELIPLPDGTSYNSYLIKGQEKTVLIDTVDPEKTEILIDNLVSAGVTKIDYIVAHHGEQDHSGSINDVLLLYPDAKVVANEKCKKMLIDLLCLDESNFLTIKEGDTLSLGDRTLEFIDTPWVHWPETFSTYLQEDKILFPCDFFGSHLATSDIFVENESAIYGPAKRYYAEIMSPFRRQIRGNLKKLEKFNIEMIAPSHGPVYKNPKFIIDAYAKWASEDVKNYVMLPYVSMHDSTRKMVEYFSQSLMDRGVKVDVFNLTDVELGKLAMGLVDAATIVLASPTMLIGAHPSAGYAAFLVNALRPKTKFMSIIGSYGWGSKMVDQLTGMMSQVKAEIIEPVVTKGYPTEDDYAKLDELADAIVAKHKEASLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ7</accession>
    <name>A0A1U9NPQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosortase D, VPLPA-CTERM-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02893"/>
    <dbReference type="EnsemblBacteria" id="AQT69698">
        <property type="protein sequence ID" value="AQT69698"/>
        <property type="gene ID" value="STSP2_02893"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02893"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="36446" checksum="454498C35CE5B14C" modified="2017-06-07" version="1">MTNSDVPVTNTTEVCEDKPKGWGSLATSTYVKTAIIALLIGYLFRNELRSIFNVWQNDASWSHGFLIPLFSLWFLNQRKKDIAELRPRRSYVGLFLLVLCLVFYPLNLVQFKIGYFSRLVILPVIGSVVLFLGGWRLVKYTWLPICYLIFAVPMPDRLYRGATIPLRKFASMISTLIIDALPDVNAVASGVIINVVHRGQELEPLNVAEACSGMRLLIAFVALGVAMAYLHWRPLWQRGVLLLSTVPIAILCNVIRVTLTGMIYIYGDPKYAKGTYHDMMGIAMLFAAFAMYGGIAWFMSNLFEEDDGSGEPKEEEVIVRRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS0</accession>
    <name>A0A1U9NPS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ORF">STSP2_03033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03033"/>
    <dbReference type="EnsemblBacteria" id="AQT69835">
        <property type="protein sequence ID" value="AQT69835"/>
        <property type="gene ID" value="STSP2_03033"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03033"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15688" checksum="D97505B3413FFD67" modified="2017-06-07" version="1">MLSNEITAVAGSDKKRKRIGRGRGSGHGKTSGRGHKGCGSRSGGSVALLYEGGSMPLFRKLPKRGFNNANFARKYEVVNISELERVFDEGTTVSVAEMAKAGLVRSVKSKVKILGDGELTKKLSVTAQKFSRSAEAKISGCGGSVKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU7</accession>
    <name>A0A1U9NPU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69929">
        <property type="protein sequence ID" value="AQT69929"/>
        <property type="gene ID" value="STSP2_03129"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03129"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9711" checksum="1A9FF30E27A8C576" modified="2017-06-07" version="1">MPVKMLKIENEYDGGLFPVAANISEYEISDEEQAHELLEEIIDSVNPVEGGRLNERAHFALSLRDAGVRGRSFLDAMAEFDSKGQADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW1</accession>
    <name>A0A1U9NPW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69972">
        <property type="protein sequence ID" value="AQT69972"/>
        <property type="gene ID" value="STSP2_03172"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03172"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1190" mass="136286" checksum="FD5B9446E71B9A29" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY8</accession>
    <name>A0A1U9NPY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug transporter MdtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdtA_2</name>
        <name evidence="5" type="ORF">STSP2_03203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70002">
        <property type="protein sequence ID" value="AQT70002"/>
        <property type="gene ID" value="STSP2_03203"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03203"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="131"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="185"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="51436" checksum="2D0AB1A655FF1007" modified="2017-06-07" version="1">MKTLTQTIKTVLAHLYFLFMALLIGGAVFGLFMGLKKKPLPQLNVFAIGLPIAIAAALLIFFLCWYLYYGRNGRRRPMLIHASAAIIFIAIGLTAARMLVSMKKAPEKVETEVVAPLLQAQKVHAKDITVTVSGFGTVQAKTTVKIIPQVSGSITELHPNFVNGGFFGADETLVKIDQRDYRNAVQNAQAAVARAEVALEREQAEAEVARREWEQLNPGKEPTSPLVLRKPQIAEAQASLKAAKAQLENAKLNLERTTISLPFNGRVLEESVDIGQYVTAGQSIATVYGTDTVEITVPLEDKQLQWFDVPLAGQSDDTGSPAVVTANFAGGTHTWDGRVVRTEGRIDPRSRMVNVVVQVPQPFENANGRPPLQPGVFVDVDIIGKQLKNVIPVPRTALHKRNELWIANDSRLHIKEVDIIRMDKENAYISAGIPDGTIVITDSLEAVTDNMKIRPRLTDNSDKKEDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ41</accession>
    <name>A0A1U9NQ41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xerD_4</name>
        <name evidence="7" type="ORF">STSP2_03254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03254"/>
    <dbReference type="EnsemblBacteria" id="AQT70052">
        <property type="protein sequence ID" value="AQT70052"/>
        <property type="gene ID" value="STSP2_03254"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03254"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="34116" checksum="D5E00DFED2BB6AD0" modified="2017-06-07" version="1">MSNSRPKKRMINDVILHSSDLTPQDSRTPQSIRPVPIPKQADSDQELVNLWLHGKSKHTQRYYRKDVQRFFEFTNKSLREIILKDLQEFADHIDEQDLVDGSKRRILSSVKSLFAFAHKLGYLPFDVARVLNLPTPKDTLAERILTQKQVRKIIDAENHPRNKLILKTLFFTGIRVSEMCSLCWKDLKERSEGGQVTVYGKGKKTRTLIIPEPLWSELMNFRGFVPEDIFVFRGRNRSTQMHSTTVLRIVKKAAHKAGLKVTPSPHWLRHAHASIACEKAPLHVVPFQLSKFNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ45</accession>
    <name>A0A1U9NQ45_9BACT</name>
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        <recommendedName>
            <fullName evidence="3">Protein-secreting ATPase</fullName>
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        </recommendedName>
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        <name evidence="5" type="primary">epsE_4</name>
        <name evidence="5" type="ORF">STSP2_02830</name>
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    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
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        <property type="gene ID" value="STSP2_02830"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein secretion by the type II secretion system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
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    </dbReference>
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        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="381"/>
            <end position="395"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="563" mass="62361" checksum="A582A62516684343" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ66</accession>
    <name>A0A1U9NQ66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70049">
        <property type="protein sequence ID" value="AQT70049"/>
        <property type="gene ID" value="STSP2_03251"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03251"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256721" evidence="1">
        <location>
            <begin position="21"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25633" checksum="C06BD94EE5547FF8" modified="2017-06-07" version="1">MENLRLAFVLLMGLVPFAFSGPGDYVDFNDGGEHVIDYHVQYSDEILDCSVRVDNDVNNVPGTKIIVESGARIDHRLYLYNNSLANINAGDVWGGLVTYDHSELIVSGGYFDGQHFFHDNSKVTFNGGVFSVNPNVAIWTMHNCETIINDGTFHALFHRDHSSLIVNGGQMNGTILEDDSSVKINQGKIGSIDCKQRGKALVMGGDIGACYTNEYSKLVILVPFQLSKFRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ73</accession>
    <name>A0A1U9NQ73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69868">
        <property type="protein sequence ID" value="AQT69868"/>
        <property type="gene ID" value="STSP2_03068"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03068"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010693675" evidence="2">
        <location>
            <begin position="26"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="739" mass="81686" checksum="858CB0683E3A1417" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB3</accession>
    <name>A0A1U9NQB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69800">
        <property type="protein sequence ID" value="AQT69800"/>
        <property type="gene ID" value="STSP2_02997"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02997"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="32839" checksum="B923540A61AE104F" modified="2017-06-07" version="1">MLAYKRKNKAFTLIELLVVIAIIALLLSILMPSLQKVKESAMAVVCGSNLRQWNIAMSFYTNDNNDTFPDADWDDDGQNDPRGQWWFLPLRPYYEDQPDIMLCAKADKKQDINSAADWVADGRYFPQDRDECWGRKIIDEDHPDYGEWFWSSYAPNSWLMDPSEGTWGAPLPTEAFWRRLTNVKQRSQVPFFVESSAVDVWPHHTDEPNSEEFGVNDGRGSMRALTLLRHGTKTNIVFMDGSLRKVDIKELWGFKWHQQYDRNYPDNPYTQDDAPWPSWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB9</accession>
    <name>A0A1U9NQB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69934">
        <property type="protein sequence ID" value="AQT69934"/>
        <property type="gene ID" value="STSP2_03134"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03134"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14237" checksum="1D18B847125558FA" modified="2017-06-07" version="1">MSERRAAVRFMPERYKRGLGAILIPDCEFPEPNERLHTWLFTGEGTLAKWTNCPGEKLLTAWGVRIPGIGKYRRSVAVDELSRYAGEQGFSLVYVAGVYGPNSFADASAMNVENNIMDNYKKMAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE2</accession>
    <name>A0A1U9NQE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfuration protein SufE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufE</name>
        <name evidence="3" type="ORF">STSP2_03357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03357"/>
    <dbReference type="EnsemblBacteria" id="AQT70153">
        <property type="protein sequence ID" value="AQT70153"/>
        <property type="gene ID" value="STSP2_03357"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03357"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15042" checksum="9A79EC0B00656077" modified="2017-06-07" version="1">MTINEIQDKIIAEMSQLDDWFDVYEYLIELGKSHPAMDESLKTQENALPGCQSKVWLITDKHNSTLHFSADSDSAIVKGLLALLLKVLNDQSPSEIASADLYFTEKIGLTSNLSPSRANGLATIISQIKEHARAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE7</accession>
    <name>A0A1U9NQE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK nuclease superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03247"/>
    <dbReference type="EnsemblBacteria" id="AQT70045">
        <property type="protein sequence ID" value="AQT70045"/>
        <property type="gene ID" value="STSP2_03247"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03247"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26856" checksum="BA9BB0DBEB965DAC" modified="2017-06-07" version="1">MEQIIKISAKNLGALALEDHCPKCFYLKLRMGFKLPYQIFPGIFSSIDSYSKKITWGCCAKNGKVPQWFDSWGEFVKPVPAPHHSKFNYTDQKTGIKLTGVPDDIFLMEDGRYFIVDYKTAKYTGNQDALLPMYQVQLNGYAYIFEKLGMGEVGGIGLCYYEPQGNAPVEQGIGNLLEQDGFVMPFRAYLKRLELDPDGVLSPLLKQVRSMWDGEQVPAGKEGCKDCKMLGEMVKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF5</accession>
    <name>A0A1U9NQF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70162">
        <property type="protein sequence ID" value="AQT70162"/>
        <property type="gene ID" value="STSP2_03367"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03367"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12938" checksum="A7B8A4916A38A3C7" modified="2017-06-07" version="1">MDTVATQNRRMHDRLEMELDVMCQTVGLSGGKLFTGKTVDVSQGGALIELHGQGLHDGQLLSIEMSVPPSENLSEFGGRISNYGRVLRTEDNLSEGFNPGSDMVQRVAIEFCDNSHSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR0</accession>
    <name>A0A1U9NQR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">STSP2_03455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03455"/>
    <dbReference type="EnsemblBacteria" id="AQT70249">
        <property type="protein sequence ID" value="AQT70249"/>
        <property type="gene ID" value="STSP2_03455"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03455"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10317" checksum="21012DF547992937" modified="2017-06-07" version="1">MKLKPLDDRVVVKPQEAEEKTAGGIVLPDSAKEKPLMGEVVAIGTGKLLENGSRGEMSVKKGDTVLYGKYGGSDVEVEGTEYKILREAEILGIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT7</accession>
    <name>A0A1U9NQT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRC-barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03351"/>
    <dbReference type="EnsemblBacteria" id="AQT70147">
        <property type="protein sequence ID" value="AQT70147"/>
        <property type="gene ID" value="STSP2_03351"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03351"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341570" evidence="2">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="3">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="3">
        <location>
            <begin position="259"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="532" mass="60400" checksum="91E3711E665B6119" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW9</accession>
    <name>A0A1U9NQW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-[dinitrogen reductase] hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03515"/>
    <dbReference type="EnsemblBacteria" id="AQT70309">
        <property type="protein sequence ID" value="AQT70309"/>
        <property type="gene ID" value="STSP2_03515"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03515"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27574" checksum="70F4B1E30641A033" modified="2017-06-07" version="1">MIGAIVGDIVGSVFEWRGTKREDFELFGAGCRFTDDTVLTVATAWAILRGEDYGVAYKRFGRKWPGAGYGGNFAKWLRSDSMGAYGSWGNGSAMRVSPVAWAFESVEEVLKEAERSAAVTHDHPEGIKGAQAVAMAVYLARRGFSKAEIVAEVGARFEYDLDRRLDEIRPGYGFDSSCAGSVPEAMIAFGESEGFEDAVRKAVSLGGDSDTQACMAGAVAEAFYGGVPGEIRAEAERRLDVELGEVVREFEGRFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR23</accession>
    <name>A0A1U9NR23_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03443"/>
    <dbReference type="EnsemblBacteria" id="AQT70237">
        <property type="protein sequence ID" value="AQT70237"/>
        <property type="gene ID" value="STSP2_03443"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03443"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12425" checksum="67AA737AC69E6229" modified="2017-06-07" version="1">MRVEESEKVLMRIFVGEADSVGGKPLYHEIVKRLRKEKAAGATVTRGICGFGAKSHMHTARVLDLSHDLPIIIEVVDSKENIDRIAPLIDDMVGDGLITMEKVQAIRYAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR24</accession>
    <name>A0A1U9NR24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase YcgJ</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgJ</name>
        <name evidence="2" type="ORF">STSP2_03481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70275">
        <property type="protein sequence ID" value="AQT70275"/>
        <property type="gene ID" value="STSP2_03481"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03481"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="38101" checksum="9A1035DE344A3D41" modified="2017-06-07" version="1">MFNNFVNRHDFTRFLWGLRHGYGRTILRRLTKGKVGRVKEAWKKKKRRATAWWELPAINRRINKCMTGDENIGQYIYLSRKYFSDKKGLRGLSLGCGKGSRERIWAGLVDFEYLEGFDISDDSIKTAKEEATIAGLDRVLRYRTADIYTVDIPEKTYDVIFVDHALHHFSPLEPLIQKISSSLKNDGLFIVNEYVGPTRFQWTDRQLELANHLRGMFPEEYRKHDIDGSIKKVIKPSRLSMIMKDPSEAIESENIMPLLKKYFDFAEYRPCAGAILHLAFEGIGGNFLNEDETTKKLFEMSFCLEDTLTEIGEVGSDYALVVCQKRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR60</accession>
    <name>A0A1U9NR60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">STSP2_03414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03414"/>
    <dbReference type="EnsemblBacteria" id="AQT70208">
        <property type="protein sequence ID" value="AQT70208"/>
        <property type="gene ID" value="STSP2_03414"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03414"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
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        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
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        <ligand>
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        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31042" checksum="AC3B240A1CE63794" modified="2017-06-07" version="1">MKEAIKKAKALIEAMEYIQEFRGKIVVIKLGGSILDDLELQKKLLKDVVFMATVGMHPVLVHGGGKAITRAMQEAGLAPTWVHGRRYTDERTLAIAEHTLVHKVNAGIAQTLREIGADAMGLHSLSSCVLFAKPLKLTGDNGRKLDVGMVGTIEDVNADLLKTLCESGTIPVIAPVAMNRMGTKLNVNADSAAGEVAAALKAEKLVVLSDTHGIFKDIDDPSSQISSATEQEVEAMVEDGIISAGMLPKVESCFTALKGGAGKAHIIDGRIEHSLLLEIYTEKGIGTQITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR92</accession>
    <name>A0A1U9NR92_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Protease 3</fullName>
            <ecNumber evidence="5">3.4.24.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptrA_2</name>
        <name evidence="5" type="ORF">STSP2_03444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.55" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT70238">
        <property type="protein sequence ID" value="AQT70238"/>
        <property type="gene ID" value="STSP2_03444"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
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        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="947"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="220"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
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            <end position="670"/>
        </location>
    </feature>
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        <location>
            <begin position="683"/>
            <end position="854"/>
        </location>
    </feature>
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        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="947" mass="105176" checksum="29C08D3537C07B5D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG18</accession>
    <name>A0A1U9NG18_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysD_1</name>
        <name evidence="8" type="ORF">STSP2_00019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00019"/>
    <dbReference type="EnsemblBacteria" id="AQT66881">
        <property type="protein sequence ID" value="AQT66881"/>
        <property type="gene ID" value="STSP2_00019"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00019"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="33897" checksum="7C1B86534CD2ED05" modified="2017-06-07" version="1">MDHLDRLESTSIHILREAYANFKSLCMLWSIGKDSTVMLWLAKKAFLGHVPIPLVHIDTSYKIPEMIEYRDRLTKEWNLDMVYGMNHEALKASETFPAGNTDRLTCCKMLKSEALRNTLSGRWPRHRFNHNLGKYEIDKNAEPFTGVIVGVRSDEEGSRSKERYFSPRDRENDWDIADQPPELWNHYKTDFAPGTHVRIHPLLDWTELNIWEYIERENIPTVSLYYNQGDGKRYRSLGCAPCTNPIESEARNVSEVIEELRSGQLSNIAERSGRAQDSEDGGGLESLRRDGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGE0</accession>
    <name>A0A1U9NGE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66999">
        <property type="protein sequence ID" value="AQT66999"/>
        <property type="gene ID" value="STSP2_00137"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00137"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18520" checksum="1BEA8A5B9A93F634" modified="2017-06-07" version="1">MRIGQQGTLTNVWAPKGSRPTAVKQTEYDWVYIFGAVNPVNGKSSAVITPTVNTDYMNHHLRFISEEAGKDVHVVLVLDQAGWHIAKQLVVPKNISLLHLPAYSPELNPIERLWAYMKSHYLSNRIYKNYEEIFNAGTVAWNNITSEMFCSICNTEWTKHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN1</accession>
    <name>A0A1U9NGN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67092">
        <property type="protein sequence ID" value="AQT67092"/>
        <property type="gene ID" value="STSP2_00232"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00232"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5947" checksum="1E939F3EDC27C885" modified="2017-06-07" version="1">MPVSTNRYGITGFVFGSKLIELGSRSYSKERGEPVRVAVWGKRFCLVLQQLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ9</accession>
    <name>A0A1U9NGQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66995">
        <property type="protein sequence ID" value="AQT66995"/>
        <property type="gene ID" value="STSP2_00133"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00133"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10044" checksum="C0588883F7B92C18" modified="2017-06-07" version="1">MPLEKHVIFGVHITDRIHHVDPVQHLFTEFGCSIRTRLGLHEAQKDFCSPNGLIVLEMVGDDDTHKEFIDKLNAIEGVEAQQMVFDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ3</accession>
    <name>A0A1U9NGZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">soj_1</name>
        <name evidence="3" type="ORF">STSP2_00166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00166"/>
    <dbReference type="EnsemblBacteria" id="AQT67028">
        <property type="protein sequence ID" value="AQT67028"/>
        <property type="gene ID" value="STSP2_00166"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00166"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="350" mass="37994" checksum="45F6C719C0B0175E" modified="2017-06-07" version="1">MRTIAVLNQKGGVGKTTTVANTAGALAERGYRVMVIDLDPQAHLTIHLGVDAESDGSGAYDVLCNSANIKEELLHVRENLWLLGANIDLVGAENELVSVVGREIILREALKEVSEFFDYLIIDCPPSLGLLSLNALSAVGEVFIPIQPHFLALQGFGKLMQTVTLVGSRINPSLKISAILLCMYDSRTTLSSDVKSDIEQFLENARGTDQPWADAEIVPIHIRRNIKLAEAPSFGKTIFEYEPACNGASDYQAVAEYLIGGNGDGQTQAETEVAEQSDEDDSSPEAVTEPEPRSVQEAREAAQTASEQTPDPDETAAFEYGADDMSDYERGDLDTNSDEQDLQNRRAMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH07</accession>
    <name>A0A1U9NH07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_3</name>
        <name evidence="5" type="ORF">STSP2_00162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67024">
        <property type="protein sequence ID" value="AQT67024"/>
        <property type="gene ID" value="STSP2_00162"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00162"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="56434" checksum="D2762CA2341BC43B" modified="2017-06-07" version="1">MDRRQFIQIAGTGAALMSLPGSVTMALEGSDKDGRLKGCRPNIILVLTDDQGYGDLACHGHPYLKTPNLDKLYSQSTRLTDYHVSPTCAPTRSAIMTGRAPFKNGITHTILERERMTLQATTIAEVLRSAGYTTGIFGKWHLGDEEPYQPCNRGFDEMFIHGAGGIGQAYPGSCADVPGNSYFDPIIRHNDKFVQTQGYCTDVFFRQALGWVKDNHERPFFAYISTNAPHAPFHCPEKYVKMYENKVDRKHRAAFYGMVTNIDENVGLLLKKLDEWGLSNDTLVVFMTDNGTSAGDYNAGMRGRKGTVREGGCRVPAFFRLPGRIAAGRDVDRLTRHIDIFPTFAELAGAEYDVEVDGRSLLDLLVDPDAQWEDRYTFFHLGRWGKEGVERWRNIKTVDPDEAKYRSFAVRNERWRLVNGSELYDIQKDPGEKENVIEQNFEIAKDMVEAYDKWWDEVRPLMVNEDVPLAEKKPYHVKYRKQKDEVGIPRWKPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH19</accession>
    <name>A0A1U9NH19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="10">RNAP omega subunit</shortName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoZ</name>
        <name evidence="11" type="ORF">STSP2_00362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00362"/>
    <dbReference type="EnsemblBacteria" id="AQT67219">
        <property type="protein sequence ID" value="AQT67219"/>
        <property type="gene ID" value="STSP2_00362"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00362"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8727" checksum="3FC984B0EC440A00" modified="2017-06-07" version="1">MLENLKSSDLIKKVGGRFKLSSLIQKRMKELMEGSRPLIDNPEGMTAMEIAVEEIKQDKIAIDWGEEEEETTEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD2</accession>
    <name>A0A1U9NHD2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">STSP2_00358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00358"/>
    <dbReference type="EnsemblBacteria" id="AQT67215">
        <property type="protein sequence ID" value="AQT67215"/>
        <property type="gene ID" value="STSP2_00358"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00358"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26684" checksum="A129E5EAD8430783" modified="2017-06-07" version="1">MRKPFIAGNWKMNKDSAGSVELAAGLAKELKDVDSVDVAVCPPFVYLQAVSNAVSGSPVKVGAQNMYFEANGAFTGEISTDMLKDVGCTYVICGHSERRHVIGETDELVNKKVKAAIESGLLPILAVGELLEEREADKTNDVVKTQVTKGLEGVSADDILKVTIAYEPVWAIGTGKTATPDQAQDVHAMIRGLIAELYSQDVADKIRIQYGGSAKPANTAELMAQPDVDGLLVGGASLKVEDFSKMIKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD9</accession>
    <name>A0A1U9NHD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atsA_4</name>
        <name evidence="3" type="ORF">STSP2_00486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67342">
        <property type="protein sequence ID" value="AQT67342"/>
        <property type="gene ID" value="STSP2_00486"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00486"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="481" mass="53659" checksum="4E1009E4BA76F4F5" modified="2017-06-07" version="1">MGFSRRDFLKAVGVGAAGVITGGLSGCMAETAKIGGKGGRKPNIIYILADDLGIGDLGCYGQEKIKTPNIDRLAAEGMKFTDHYSGSTVCAPSRCSLMTGRHTGHCYIRGNWEVQPEGQMPLPAEKVTVAEVMKRAGYTTGAFGKWGLGYPGSEGDPINQGFDEFFGYNCQREAHHFYPDHLWHNDKKVILEGNKGDSKQQYSHDLIAEKSLEFVKEHKDEPFFMFVPFTIPHAELAVPEDSLEQYEDKGWSEKVYKGSKHGYGRQEQPRAAYAAMVTRMDSDVGRLMALLKELDIDDDTIVMFSSDNGAHTEGGNDWRFFDSNGPFRGIKRDLYEGGIRVPMIARWPGKIEAGSVSDHISAFWDILPTCAQLAGVDAPPNIDGLSFVPELIGKPQKKHEYLYWEFPVWGGRQAVRMGKWKAVRLNVKKNPEAPIELYNLNKDIGEQNNVADQHLEIVAKMKEIMEKAHTPSEKFKLFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE7</accession>
    <name>A0A1U9NHE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L(+)-tartrate dehydratase subunit alpha</fullName>
            <ecNumber evidence="8">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttdA</name>
        <name evidence="8" type="ORF">STSP2_00378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00378"/>
    <dbReference type="EnsemblBacteria" id="AQT67235">
        <property type="protein sequence ID" value="AQT67235"/>
        <property type="gene ID" value="STSP2_00378"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00378"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="31842" checksum="36E73DA9FDC46387" modified="2017-06-07" version="1">MRRIEYAKIVETVARLAIESAYELPGDVLGAIEEARAAETDERARRILDQLIENARLASEERIPLCQDTGLAVVFVEQGEDVCVEPPKSSREAGASVAGGTHRPAALITAAINEGIADGYGRGLLRKSVVAEPLRERANTKTNTPAVIHHSVVPGDELSIYVMSKGGGCENKSQVRLFNPTDSAETVKGWIVDVVREAGANACPPFVVGVGIGGNFEQACLIAKKSLLRGMGEANADEFYAQMEADLLAAVNELGIGPQGLGGRTTALAVKIETAPCHIASLPVAVNIECHSHRHKHAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF3</accession>
    <name>A0A1U9NHF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66936">
        <property type="protein sequence ID" value="AQT66936"/>
        <property type="gene ID" value="STSP2_00074"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00074"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="79" mass="9407" checksum="6CE2BFBBB17718FC" modified="2017-06-07" version="1">MPDRDINIGRVDSLHHVAGKKNLHNEVENKEHKRKREQKKREQRRRAMQQQLDELVEKELESLSEQTDDDGEGHIDFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ7</accession>
    <name>A0A1U9NHJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67247">
        <property type="protein sequence ID" value="AQT67247"/>
        <property type="gene ID" value="STSP2_00390"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00390"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9988" checksum="360F465B500ACDC8" modified="2017-06-07" version="1">MGNTSRHHHFIPRFYLKGFLFEAEENPRLAVIDLKKKKQFQTNTRNVGAIRDFNRVDVEVTCPRIMYQLLLESCPSHLSCIAVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM1</accession>
    <name>A0A1U9NHM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00557"/>
    <dbReference type="EnsemblBacteria" id="AQT67413">
        <property type="protein sequence ID" value="AQT67413"/>
        <property type="gene ID" value="STSP2_00557"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00557"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010694615" evidence="1">
        <location>
            <begin position="24"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="243"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="454" mass="51490" checksum="D50BA293A728F600" modified="2017-06-07" version="1" precursor="true">MSKLSKSLLIISILAVICQPSFAGEWKKLFNGENLDGWERKNGKAKYYAEDGVLVGQTVAGQPNSFLCTTDTYSDFILEYEMKLGGAINSGVQIRSESKPEYGNGRVHGYQVECDPSDRAWSGGIYDEARRGWLYPLYRGHEGRAAFNPTGWNKFRVEAVGPHIKTFVNGVPCADLVDDMTAEGFIGLQVHSVPKRHDGMKITWRNIRIMTDDLEDELSEDYMAIHQVNLVPNYLSEREKAEGWKLLWDGKTTDGWRGAKLDDFPEKGWKIEDGVLTVMPSGGAESAYGGDIVTRKKYGDFELKVDFKFTKGANSGIKYFVDPKLNKGPGSAIGCEFQILDDRNHPDAKKGVNGNRTLASLYDLIPAWNPWGKREKRNGWNQARILADGKHVEHWMNNLMMLEYERSTQMWRALVDYSKYKDWPDFGEAEKGNILLQDHGNLVHFRSIKIRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM4</accession>
    <name>A0A1U9NHM4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">thiG</name>
        <name evidence="8" type="ORF">STSP2_00563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00563"/>
    <dbReference type="EnsemblBacteria" id="AQT67419">
        <property type="protein sequence ID" value="AQT67419"/>
        <property type="gene ID" value="STSP2_00563"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00563"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="256" mass="26804" checksum="FE1CDE45B5954039" modified="2017-06-07" version="1">MEKLKIADKEFTSRLFIGTGKYSSNADMAKAIDASGSEMVTVALRRVDIRNENDDMLAAVDRDRCVLLPNTSGARDGEEAVRLARLTRAASGINWVKLEVTPDPYYLLPDGGETLKAAETLVNDGFVVLPYINADPILAKKLQDVGTATVMPLASPIGSNQGLTTRAAIEIIIEQATVPVVVDAGLGLPSHAAEAMEMGADAVLVNTAIATAGDPAAMAEAFKLATEAGRTAYLAGKAAISKTANASSPLTGFLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP3</accession>
    <name>A0A1U9NHP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67439">
        <property type="protein sequence ID" value="AQT67439"/>
        <property type="gene ID" value="STSP2_00586"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00586"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="125" mass="14313" checksum="27EC6E854DD602BD" modified="2017-06-07" version="1">MSKDVRKCFLASLVIWNVASIGAWLWIWSLFNMADISRQEKNEVTVIFALTEAWLILTLVYCLGWHTKLFRILSDITNALAVLAGIYYLFMIHPGIVNLLVPAIYLISALFYFCSQHCPVKRQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ2</accession>
    <name>A0A1U9NHQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline-sulfatase</fullName>
            <ecNumber evidence="4">3.1.6.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">betC_1</name>
        <name evidence="4" type="ORF">STSP2_00596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.6" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00596"/>
    <dbReference type="EnsemblBacteria" id="AQT67449">
        <property type="protein sequence ID" value="AQT67449"/>
        <property type="gene ID" value="STSP2_00596"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00596"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047753">
        <property type="term" value="F:choline-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011984733" evidence="2">
        <location>
            <begin position="27"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="483" mass="53748" checksum="1DF1F1659147BA93" modified="2017-06-07" version="1" precursor="true">MRITRRGFLRLCAVGGLSLCVSKAVGAEGALSRKGKRPNVILCMADDLGWGDVGYNGNDVVKTSNLDAMARAGVRFDRWYSASAVCSPTRGSCITGRNPERYGVHYANVGHMRKEELTIAEALKPLGYRTGHFGKWHLGTLTKEIKDSNRGGERGVKNYSPPWENGFDVCFSTEAKVPTYDPMRQPAGEHSNKWWNPVDKEQSKEYGTHYWTGADELVTENLEGDDSRVIMDRAVEFISASAKKDEPFVAVVWFHAPHLPVVASDEHRAIYEGLDGYSQNYFGCITAMDEQMGRLRKLLRELGIEEDTMLWFCSDNGPEGRKGQAPGSTGGLRGRKRSLYEGGIRVPGLLEWPARVKEAHAVKAPCCTSDYMPTVMDAVGGTVKKGPEPVDGVSLLDMINGKTDERGEPIAFEIRRQVALIGDRYKLYSRNEGEDYELYDILTDPSESEDITEKHPDAAQEMIAKLDKWRRSCAESLAGKDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU8</accession>
    <name>A0A1U9NHU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmE</name>
        <name evidence="7" type="ORF">STSP2_00649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00649"/>
    <dbReference type="EnsemblBacteria" id="AQT67501">
        <property type="protein sequence ID" value="AQT67501"/>
        <property type="gene ID" value="STSP2_00649"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00649"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30009" checksum="8BC5F27ED573966A" modified="2017-06-07" version="1">MKINRFYCENITPDQVVLAGSEAHHAIHVMRVKPADKVELFDGKGSFAVGTVVDVGRKTVSLEVGEIEHADLSGRAQVVMAASFAKGQRNDWMVSKCTELGVDHIAGVVFDRTVKQPKGKSADKRNHNLAVTAAKQCKRLTLPKFSMHNGLEDAVAELKNEYPDAVLVFGGWSESAVPVCKVVNDIYNPGGNDLCKEGLPQDSKPFPSKDLHSQGNKKKCRDVIAIIGPEGGFSDEEVEFLKSAGAVEVQLTKTILRIETAAVAFASIFCTARDVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW1</accession>
    <name>A0A1U9NHW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67190">
        <property type="protein sequence ID" value="AQT67190"/>
        <property type="gene ID" value="STSP2_00333"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00333"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045466">
        <property type="entry name" value="DUF6498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20108">
        <property type="entry name" value="DUF6498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25886" checksum="A28772E31146F4E0" modified="2017-06-07" version="1">MSRFIETAAALFRLDPDELRSSRISIIVLIFANLVPLYGLFFLGWQAINILLIYWLEAFIVGFYNLLKLTTARCDDSTEHLRKLLDVPAFAMHFSIYCAVVGFIVFKEFSGYQPPPPENLDVPTYFSLVGIGNDFWTHIKSLFTPGIAVAAVIMFISHGVSFTQQLADRPLYSGRSLTALTFKPYLRVVPIHIVAAAGVAITQATGSTAAIILTLVLAKTAIDLAFFTIEKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI32</accession>
    <name>A0A1U9NI32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00729"/>
    <dbReference type="EnsemblBacteria" id="AQT67581">
        <property type="protein sequence ID" value="AQT67581"/>
        <property type="gene ID" value="STSP2_00729"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00729"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26773" checksum="F8A6D3F3BFF168DD" modified="2017-06-07" version="1">MLTNLILFLSFVVCSFIVVRIGAIAFQLTGVSWPLAKFQSLSCFTGTGFTTRESELITSDPRRRRIATILIVLGHAGLVSMIATFANTIRPSAIKEKLAVPYLPFDVPYQILPWVNIGVIAVGVYVIYRVFTNANFVKKMTRKMRRLLVRQSDVVRPVTFEELMFVSGGFGISRISINRKNSLIGKTLRESRLRRKNITVLAIERKETTTANPPADSILREGDELICFGNLDRMKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB3</accession>
    <name>A0A1U9NIB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsR</name>
        <name evidence="5" type="ORF">STSP2_00474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00474"/>
    <dbReference type="EnsemblBacteria" id="AQT67330">
        <property type="protein sequence ID" value="AQT67330"/>
        <property type="gene ID" value="STSP2_00474"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00474"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9745" checksum="85BA6D11AF8EA28D" modified="2017-06-07" version="1">MAKRRKKRKFATGLREQSQCRFCREKKNYIDYKDIDTLQKLLTNRGKIFSRKRSGNCAKCQRRVKRAIKRARFMALLPYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE5</accession>
    <name>A0A1U9NIE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SOUL heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00860"/>
    <dbReference type="EnsemblBacteria" id="AQT67712">
        <property type="protein sequence ID" value="AQT67712"/>
        <property type="gene ID" value="STSP2_00860"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00860"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31499" checksum="E3A37D7C836ED06A" modified="2017-06-07" version="1">MGFIGKTTGLLGGIAVALGLAGCAVSQQTAYTNAGSTVTKGEVIEEIEKAVDGAEELKGEGETGAARDELAAKAQELGSKLGSSDAGYVLSEAAREEVTMSDEQAFDYLKRRMETAVDALKFEANVSADLPEGWPEPSMVGLVRLKKYPVVRMVKAEGADQGETFGVLFSHIKEREIPMTAPVQMDYEAEGEGMRMEAMSFYYPSEEVGTTGQADQAVVFDSEPMKVVSVAVKGAYNKGTYEPAVEKLKAWLEEQDKYEAVGGVRVLGYNGPFTPWWMKYSEVQIPVSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ8</accession>
    <name>A0A1U9NIQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67614">
        <property type="protein sequence ID" value="AQT67614"/>
        <property type="gene ID" value="STSP2_00762"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00762"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527455" evidence="1">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="329" mass="36508" checksum="BFF6730C906A104C" modified="2017-06-07" version="1" precursor="true">MRLFCTLLISLPIIAICGCGPQAQTAEGDDELLIVEFDPDRPVSYRMVSERVVDVNLGQKTGGGSQTATEKLELIMSYKPQGEINPYGLTTIEATCRSASVQRKTLSGRTENTDAVTFLQGKTFTFKVGPTGKIEDYTDLERVVKELGAKAFAGSADQGNIKNADMISDFVTLQWYLWDSVGKLASANPPVEVGREWQTTQLIPFASPIRGIRRTTYELTDIKTTDEGKKAVFAMSFEPTTGKLENIPVPYDRQYRMRGLFGFLRNYELKSLEGSGKQVFNIDRGVVESETQNYTVKLSASFMLPLQDTEPALTVDQNISIDLIEQPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR1</accession>
    <name>A0A1U9NIR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase pkn1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pkn1</name>
        <name evidence="3" type="ORF">STSP2_00972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67822">
        <property type="protein sequence ID" value="AQT67822"/>
        <property type="gene ID" value="STSP2_00972"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00972"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="576" mass="64517" checksum="49104FD0A7BDDD65" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV5</accession>
    <name>A0A1U9NIV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67851">
        <property type="protein sequence ID" value="AQT67851"/>
        <property type="gene ID" value="STSP2_01003"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01003"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="389" mass="44085" checksum="5A3E02717B556EA6" modified="2017-06-07" version="1" precursor="true">MSGKVTLQMFVVLAVVGCVIALWGGAVLAAEEGSDAGGERAADVMEIAGKEVEFVMFEPVYEWRIEPFERGPVDPGYAAKVMMRTDRDISRNVESIDLVNGILSTEAAEGFSSEQRDFLKYTSAPRCLQRLYARYGAQTWVVFGVSEKDTKLMVKAFAQFARDYGEQFIEEKRQRMEELQGKIAELKDKREKNEKLIEEYRERLEKVKESTIYTSALEAREAATRLTSRMEELKLAIAALGPKAEVYAGTPKELEFKAELKAAENEFEVVKKMRDEAKDLSELPGKIDALSLSVEGIVTRSMPNRPRGRTPNRRTPVRRPPASNTRGLTTFRGTELEGLRHDLEEVEEWLSEPHISLVRSEIYDAVSIQPVEVVETDRRDTPWTPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ44</accession>
    <name>A0A1U9NJ44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">napC</name>
        <name evidence="12" type="ORF">STSP2_00684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="9">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NapC/NirT/NrfH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00684"/>
    <dbReference type="EnsemblBacteria" id="AQT67536">
        <property type="protein sequence ID" value="AQT67536"/>
        <property type="gene ID" value="STSP2_00684"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00684"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019333">
        <property type="term" value="P:denitrification pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024717">
        <property type="entry name" value="NapC/NirT/NrfH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000013">
        <property type="entry name" value="4_hem_cytochrm_NapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_NNT" evidence="11">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="21239" checksum="246758B2C4CB5D5A" modified="2017-06-07" version="1">MLRLVKRIYAFAWRTFRRYGPAFLAGLAFALLAFIGINAAAKPTSASEYCGTRCHEMKVSYRTWELSTHGTNELGIEVDCIECHLPPKEKYFTHMTAKAYAGAKDFYMHYFGPEYDREEIRRKVLEHMPDSRCTYCHDDLLTRPSSSAALKAHKTAINNPDDPENRCVACHESVGHERKRKLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ49</accession>
    <name>A0A1U9NJ49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67610">
        <property type="protein sequence ID" value="AQT67610"/>
        <property type="gene ID" value="STSP2_00758"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00758"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="39889" checksum="F2C5EBB442EB1432" modified="2017-06-07" version="1">MNFQPDYRMILDVLANRRPTRLPLYEHIIAPQVMEKILNRKFSDLENGDANDLGLFFENYCHFFKSMTYDTVSYEVTIADRLPGHGAILGGKPGPIQSRSDFQAYPWDRLPELYWAEAQKRFAALEEMMPEGMKAVGGVGNGVFEISEDLVGMEYLAYLQADDPELHAELYTRIGDLMYKLWDRFLKQFGNAYAVCRMGDDLGFKSGFLISPATIRKHIMPQYKRITDLIHSHGKPFLWHSCGCVFGVMDEMIELGIDAKHSNEDQIAPFDRWIDLYGQRIGLLGGIDVNLLCLETPEYIKSRVQADALRFRQKANGFALGSGNSIPNYVPVEGYLAMVEAAQAVRKDRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ90</accession>
    <name>A0A1U9NJ90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-deoxy-D-manno-octulosonic-acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68002">
        <property type="protein sequence ID" value="AQT68002"/>
        <property type="gene ID" value="STSP2_01156"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01156"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="305" mass="34041" checksum="3B023BFB236B52F9" modified="2017-06-07" version="1">MMMEPGKSGIGSIESHAGKIAVGGGWRGFVATRYRDGESLSMEEWRRVLEDVDGLVDGGAKVLKKGSLVDVVCGELEIGGIKRKVVIKRMLPENGLRGFCRSLLRGKAVRNFRTAMRLVRYGIPTAYPLAGIERRVAGSSRENIFIAEYIPESTNLYNYFHDECGRVSQDAGLKANIGKQVGQILAQMHKGGLWHRDAKGGNFLVEGKGRSRPRVLLVDMDGIKRYGPRRGECRWRPFVKLGATLMASPAIYVSDYLRSFRIYCNLTGVGRDEMQRRFRRISREATGVRLLTAAKAAMKQAREDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB1</accession>
    <name>A0A1U9NJB1_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67905">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="38381" checksum="39D9EA88FCA20A20" modified="2017-06-07" version="1">MSRQDNYNTLGQAVKEYRGAMTQGDLARRMTEDAEQRHYPTRPDGKADTVSQSWISRLEDGKLKRDVSEDRRRWIARVLGADEDLFLRLPIAKQRAGDEHARTAGQTSYVIDFAKKLLSNLEPGSDVWFDSPLQEEPLSARKPEALWCHTQIITEGKSRVFVFSSERERKSVLKMPLLLAMVLGKLENDEDVETDEIIAGNGPFDDSLEICREVVTSFQRWRSDPITLSGQLFSFLQERLVLYHRTRFSDVPERPNPLTLIVVRSDASPTRRDSVPTSLAILAYGLGWADYYDKSEEWVSYFERAIEDGAFTPVTYSKADIAELAENKRIPLTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC3</accession>
    <name>A0A1U9NJC3_9BACT</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01187"/>
    <dbReference type="EnsemblBacteria" id="AQT68033">
        <property type="protein sequence ID" value="AQT68033"/>
        <property type="gene ID" value="STSP2_01187"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01187"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
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    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="182"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="568" mass="62337" checksum="1FFA78515998DE34" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC6</accession>
    <name>A0A1U9NJC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_3</name>
        <name evidence="2" type="ORF">STSP2_01186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68032">
        <property type="protein sequence ID" value="AQT68032"/>
        <property type="gene ID" value="STSP2_01186"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01186"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N_methyl_site"/>
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        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29565" checksum="5146C01874C10B57" modified="2017-06-07" version="1">MKGVEVLRRVRGRSGFTLIELLVVIAIIALLMGIMLPAMSKVKESARFTVCQSGLKQYGLAGKMYLMENSDKFPHSYNWLYKYSKVQSPCAWHDADLNFHKEPDVAGVLWPYLASKDLHVCPTLRGVARDHGADHWGHSGATPIDPQYGYCMNGYFGSWPFDAGNGKKTYVKRSGQVKRPGRKVFFGEENTWTIEKWSDSSLNNNNIVAMTLENGDWKNACAFATFHKTKGNDRNSGISNAVFLDGHVETVNYKQTQELTVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC8</accession>
    <name>A0A1U9NJC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01183"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="850" mass="94386" checksum="B3A5E19D91CA4BE8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD0</accession>
    <name>A0A1U9NJD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67848">
        <property type="protein sequence ID" value="AQT67848"/>
        <property type="gene ID" value="STSP2_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01000"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="19678" checksum="8FA1766EA05DE52B" modified="2017-06-07" version="1">MSRDVKKLVVGVVLFVLGGLVVPVAGFVFFFYPMVSAEPAARFVAPANVRVEIEEAGRYVLWNEYESIYKGQTFAVDEDLPSGISMSFVGPAGVGDVEMDAAMNSSVSTPSTERKSVGVFEVDEPGRYVLSVAGEFEARVFSLRKSVLYRSLMAGLGVLAVSVPLSLAGIGLGVAGIAGMVRSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE4</accession>
    <name>A0A1U9NJE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68052">
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        <property type="gene ID" value="STSP2_01207"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01207"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="418" mass="47663" checksum="0AC54274AC372108" modified="2017-06-07" version="1">MAKAKKNHNLPGAIYKNGNRWWWKVQLPGEDKLRSRPLKPFGSSLATKDHCVAVECAKVLMAKAVFESQQDPEERIENIAELCKAYMAHAREYYKKADGSPGKEVKQIEYSIKPLVNRFGNLSIDEFGPLKLVEVREQMIGRGWCRNLINQRVGRLKRMFKWAVSREIASSVLYNSLATVEGLRKGRTAAKESRPIKPVSEDHVHKSLPYMTKVVANMVELQLLTGMRPGELVIMRPCDIEKSEDIWHYCPERHKNDYRGFKRIISIGPRGQEILRPYLLRSPEAYCFSPAESERQRLSKLHQERKTPPGYGNRPGSNRRPEPKRKPGECFTSGTYGNSVRKAVKAARRDVEKRGGDPDKELPKWTPYQLRHTAATKARKLFNYETAGALLGHSNMSATQIYAERNQGLADMAAQKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF6</accession>
    <name>A0A1U9NJF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein, rSAM/lipoprotein system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01016"/>
    <dbReference type="EnsemblBacteria" id="AQT67864">
        <property type="protein sequence ID" value="AQT67864"/>
        <property type="gene ID" value="STSP2_01016"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01016"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1539" mass="167879" checksum="F3B76EF5BC329D39" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ4</accession>
    <name>A0A1U9NJJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67904">
        <property type="protein sequence ID" value="AQT67904"/>
        <property type="gene ID" value="STSP2_01056"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01056"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="25783" checksum="CA70667486A447B3" modified="2017-06-07" version="1">MPHVNKIIFRKMRREFARFPNLDVSETVKLGKVGFFDNRRAFFNWKTSLDRLNLFISEEPRDDKFPICDELYTSYGGVETQFRVTEEKFGTADFLFRKKYAVAAQAIGTESKALDIDSLEQQIVKGINNGSLKWNKKWVVVTEVFVASAFSLLVGSSSGGMASVRTNIPITQLGFNIADPNLSLSISGAKQMGKQIIARRNVVPFFRVHRVCGNWKSGKLSLEPYGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV1</accession>
    <name>A0A1U9NJV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine betaine/carnitine transport binding protein GbuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gbuC</name>
        <name evidence="4" type="ORF">STSP2_01012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01012"/>
    <dbReference type="EnsemblBacteria" id="AQT67860">
        <property type="protein sequence ID" value="AQT67860"/>
        <property type="gene ID" value="STSP2_01012"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01012"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="35"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36518" checksum="45B61A8ED2F653F5" modified="2017-06-07" version="1">MKKAIIPIVIVVVLIGIYVAMTGTQEGDQKKDTPTVELVYVEWSSEVASTNVVRAVLQEVMGYETEITPVSAAAMWESVGTGDMDGLVAAWLPTTHSHYLENNKDTVVDLGANLVGTKIGLVVPDYAPAQSIEDLKLYADQFDRKIIGIDPGAGIMSKTETAMEEYSLDEYELVEGSGATMTGALANAIANEESIVVTGWTPHWKFTRWDLRYLQDPKNVYGGAEEIHTIVRKGLKDEMPKVEMFLDQFKWEPADMQELMNWNKQESKPYENAKKWIKENPEMVLEWVQGTGFEDQVDEKLAAIDASDAVQLEQDEATEQDADAETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW7</accession>
    <name>A0A1U9NJW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68038">
        <property type="protein sequence ID" value="AQT68038"/>
        <property type="gene ID" value="STSP2_01192"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01192"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="44" mass="5144" checksum="6A8BF0CA862CD9B2" modified="2017-06-07" version="1">MSVYCRVIKLTRLVAKIFANMFWAGGQAERGAGRERFRDLHKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ9</accession>
    <name>A0A1U9NJZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01292"/>
    <dbReference type="EnsemblBacteria" id="AQT68137">
        <property type="protein sequence ID" value="AQT68137"/>
        <property type="gene ID" value="STSP2_01292"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01292"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="76"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35724" checksum="FA23F147B2EB94C7" modified="2017-06-07" version="1">MSIDRRQFIGGAAAAALGAGAAVGAENGRGGKVGKSKSVNAKGAGLMSGRGNPIAISTYSFWRFKEGLKLPIEQCIEEAAEMGFDGVEILHMQMESEKTSYLNKLKKTALVNGVDLCGMSTHQGFVSPDEEKRQRNIDHTIKCIELAYELGIPCIRINTGTWGTSESFDELMENRGIEEPLEGYTDEDAFPWVIGSIEECLKVAEKRGVVLGLENHWGLGRTPEGVLRIVNAIDSEYLGVLTDTGNFLEDPYDKIVKMAPQTVFMQAKTYFGGGLWYTLDLDYDRIAKIMKESGYKGYISLEFEGQADYKEAIPKSLELLRGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK44</accession>
    <name>A0A1U9NK44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01259"/>
    <dbReference type="EnsemblBacteria" id="AQT68104">
        <property type="protein sequence ID" value="AQT68104"/>
        <property type="gene ID" value="STSP2_01259"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01259"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888756" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="348"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="699" mass="74940" checksum="123E74804CE642C5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK70</accession>
    <name>A0A1U9NK70_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ywqE</name>
        <name evidence="4" type="ORF">STSP2_01480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01480"/>
    <dbReference type="EnsemblBacteria" id="AQT68321">
        <property type="protein sequence ID" value="AQT68321"/>
        <property type="gene ID" value="STSP2_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01480"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29391" checksum="C4E902CC3F2D7B34" modified="2017-06-07" version="1">MVSENKFIDIHCHCLPDLDDGPRNMAESIQLCQALVEDGVKEVIATPHWLGRYDGKYGLSEVLTSAEILQKELIKQNIPLDILLGAEVRIDERLMTMIDAGRIPTLGMSGKYLLLELFNEFAFDISPIAEQLHKRNIIPLIAHPERVPAIIRNKSLLYKWHIKGVRLQVTAESLTGAAGPQARDNALEYISNGWVAAVASDAHGLAVRWPAMKEAYGIVCEAFGEEVAQALFITNPGRIASGVDLCIIPPCISPQRSVSGMLKKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD3</accession>
    <name>A0A1U9NKD3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">alaS</name>
        <name evidence="13" type="ORF">STSP2_01519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01519"/>
    <dbReference type="EnsemblBacteria" id="AQT68359">
        <property type="protein sequence ID" value="AQT68359"/>
        <property type="gene ID" value="STSP2_01519"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01519"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="2"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="905" mass="99678" checksum="21F8C5DF006DD55B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD4</accession>
    <name>A0A1U9NKD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">STSP2_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01204"/>
    <dbReference type="EnsemblBacteria" id="AQT68050">
        <property type="protein sequence ID" value="AQT68050"/>
        <property type="gene ID" value="STSP2_01204"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01204"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="23634" checksum="B8F28EE9606A2C45" modified="2017-06-07" version="1">MRKINDYPDVSLTSEELDGRLNFKDIFGRNGAVHLEIGSGKGTFLVHQAKAQPGVNFLGIEWANKYYCHAVDRIGRWGLDNVRITRADAAQFLREHVADESLDCLHLYFPDPWPKKRHHKRRFFNAKNMDEVLRCLVPGGRVNVATDHAGYFSQMEEVTQGLGDRIERVEFVRAAGAEDGEMVGTNYERKYAEEGRQTFTLAFLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK4</accession>
    <name>A0A1U9NKK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68264">
        <property type="protein sequence ID" value="AQT68264"/>
        <property type="gene ID" value="STSP2_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01420"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="101" mass="11516" checksum="BC4B3E533DADC6E3" modified="2017-06-07" version="1">MGLMMILTPVKNGNNMNRPKEKDLKMLIGIFVFLFVIIVLVQGAFISPWFYGLSLAIISAFLLFAYKKKEWKKVEWLSYALVLNLTMIVIGVGLTLLSYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM3</accession>
    <name>A0A1U9NKM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01221"/>
    <dbReference type="EnsemblBacteria" id="AQT68066">
        <property type="protein sequence ID" value="AQT68066"/>
        <property type="gene ID" value="STSP2_01221"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01221"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="203"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="441"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="551" mass="60167" checksum="390C4DF60880FE2F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ2</accession>
    <name>A0A1U9NKQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68377">
        <property type="protein sequence ID" value="AQT68377"/>
        <property type="gene ID" value="STSP2_01537"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01537"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7462" checksum="E24148ECBDE35683" modified="2017-06-07" version="1">MASMCTTFEQIAGSVNDLDKNGLVNKIMNFDGAFPMDFTEGYLKTLNEDQLRHILASAILTKLKHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ5</accession>
    <name>A0A1U9NKQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68170">
        <property type="protein sequence ID" value="AQT68170"/>
        <property type="gene ID" value="STSP2_01325"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01325"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="23519" checksum="341EE0C82D6F6C3A" modified="2017-06-07" version="1">MDDTRYRRIRSLVRKLNRQRHEQAKKIDLLCNDMVGAHREFVLQLENLSAGFTFYESLLGHNDLGQILATTFNYVYRHVNECEVAIFLTDGHNFQVHQAESRTAISKKVEKLWGSFTNETVNEISRANAITELGTMFELGLQGNLRLLNEISAAAVPIGRVNGPLGFILICRDIANPLTSGELAKVNAVSLGLCRSIRSGNCLADPSSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS0</accession>
    <name>A0A1U9NKS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tagO_2</name>
        <name evidence="7" type="ORF">STSP2_01483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01483"/>
    <dbReference type="EnsemblBacteria" id="AQT68324">
        <property type="protein sequence ID" value="AQT68324"/>
        <property type="gene ID" value="STSP2_01483"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01483"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="494" mass="54215" checksum="CD815E1EA8A23EE6" modified="2017-06-07" version="1">MQTYILTISLSFLLSLAITPLVIAWARKLGVVDRPNARSAHKKPVARAGGVAIFVACMPVVVGILAVPNAIGESFREIWPQVTVLLAGASVMFAVGLLDDVFNLRARYKLVVQVLAAVAACAVGIRIEVVEVRDLFTIDFGIYSWPLTLVWIVGVTNAVNLIDGLDGLAAGISAIACGVIAVLSVFFGNAVMTVIMLSLMGSLTGFLFFNFNPARVFMGDCGSLFLGYMLATASVMCSVKSQALVGLALPILALGVPIFDTFFAMLRRFLERRSMFAPDKGHFHHRLQELGLHQRHVVMIAYAVTIAVAALGCFMMATRSLASIVLFIALLAMIVFIFRWVGSVRLRETISGLRQKYSLAQRIKSEIRGFEDVQLHFRNATTFDQWWESVCLAAEQMDFSSISMPLSSRDGTQRILSWHSKSNNVRKDDLISMVVPIKDRRSDSPLRLDIVLHTNGCLESAGRRVTLFGRLMQENGPKTLSGDRDLGDRQAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL73</accession>
    <name>A0A1U9NL73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01743"/>
    <dbReference type="EnsemblBacteria" id="AQT68575">
        <property type="protein sequence ID" value="AQT68575"/>
        <property type="gene ID" value="STSP2_01743"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01743"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032638">
        <property type="entry name" value="Porin_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16930">
        <property type="entry name" value="Porin_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="447" mass="50229" checksum="16545C987746D32D" modified="2017-06-07" version="1">MRKLFLCVVIAVFCGEYARGEQSVEDRLARLEALLQAQQEQIQTQQAEIESLKKELKSSQGGQDDVERADQEDLQLPVQDGAAIGQREIDEMVDKALAEREKDGTPEWLERIKLKGDFRFRHEHIDDEVADRDRDRTRLRFRIGADAKVNDEVDVGFRLASGSDAPTSTNQSFDNSFTSKDFFLDRAYVDYHPAALEGVNIYGGKMPNPYYFPGNSDLMFDTDVNPEGAALTVKNTLADNTEMFGSAGVFYVEERPEDAESSLWAAQAGMKRELFADTSLTAGLGYFDYGNAKGFQAFESSYTGSRLGNTLVNDRYDMDYDIFQMFGQLGWDAGGVPMVVFADYMKNTDATVSGDTAYLFGTGLGKRSKPGTWDVFYNYRRIESDAVIAAFTDANFGGGRTGSKGHKVNFNYQVSKNWVFATTYIWGDFVGSGKDYRDLYFDMKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA8</accession>
    <name>A0A1U9NLA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EIIABC-Fru</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fruA_1</name>
        <name evidence="3" type="ORF">STSP2_01783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01783"/>
    <dbReference type="EnsemblBacteria" id="AQT68615">
        <property type="protein sequence ID" value="AQT68615"/>
        <property type="gene ID" value="STSP2_01783"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01783"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18554" checksum="F62248A5D80EF49B" modified="2017-06-07" version="1">MFIKDDRNSVNADSQSSRPKPGTALVDKACIGFMDKCSKQAALNSLVDLIGKSKDVSDVDEVRTAIFHRETLMSTGIGLGLAFPHARLSSVKKPAMAVGLCREGIDDYESLDNAAVHLVFMIVAGKDQHAQYLRLLASISKKLKVENVRKSLINAPDEDSFYALLKEMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF4</accession>
    <name>A0A1U9NLF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68568">
        <property type="protein sequence ID" value="AQT68568"/>
        <property type="gene ID" value="STSP2_01736"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01736"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36874" checksum="255335931F23A245" modified="2017-06-07" version="1">MNDILDSKAGSPELDCPDSSLNNIPALAFSIAAYAFLSILLLAPYFWKFGPTQLLIPFSLTIAAAGAFLFTTSFSSRSASFLAGLLYAFSPYSLSLLTLHPAAMLIFTCVPWILCLGFTAALPQRTIRQIIAICLLALVTWAFFAYTESLSFYPAPVHLHTGLQPLHELVSLPVNSPTLFSFNLYHIGSVIALYAFCRHILDLPPLLVSAATAGLLLSMSDPILAISPVIWRAIPIAVLCLLTATAFDTLTAQGKSSKKEKWFTLLLLIPIAVTTASNAATLLHTPYAILRLSVTACIIALIIISTWTGRPQKSIVKPILFTALAADMICHAMHLTDHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH7</accession>
    <name>A0A1U9NLH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEP-CTERM protein sorting domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68657">
        <property type="protein sequence ID" value="AQT68657"/>
        <property type="gene ID" value="STSP2_01826"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01826"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11519" checksum="3889C69C1F4EF59B" modified="2017-06-07" version="1">MDFSTTNFSVVSDLSPLRNVKSLERLSFANCVDLDGDEVAELVANLDSLNWLDVTGPWDSWNADVQADLLAWDAAEGNELVVPEPATFALLGLGAIATLRRRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ2</accession>
    <name>A0A1U9NLQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68664">
        <property type="protein sequence ID" value="AQT68664"/>
        <property type="gene ID" value="STSP2_01833"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01833"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="24162" checksum="2F2428B1BAA3F118" modified="2017-06-07" version="1">MTNPEHPPPRSQLPKTHKADHTQTPQPKTKKEKDIHRLQNTSCRKIPNPNPVLIMIIIINKTPLQTFSSCSFVPSAVKLLSKISYLTGRILPVISTLLSPHLCLLLPHFFLVLPYFCPTFHPRKTPKNSRFQPMSYLPGVHAPLIYRHFTPHFTPLTGSFYRLFTQFQYPRPLPSQPLRKLIPLHLLPQPVTLFYRLYHEVFVLLIPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS8</accession>
    <name>A0A1U9NLS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdsC</name>
        <name evidence="5" type="ORF">STSP2_02059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02059"/>
    <dbReference type="EnsemblBacteria" id="AQT68883">
        <property type="protein sequence ID" value="AQT68883"/>
        <property type="gene ID" value="STSP2_02059"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02059"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18721" checksum="C1F34B6B90020CC7" modified="2017-06-07" version="1">MDFSNIKMLVMDVDGVLTEGTVVIHEDGSESKFFSLVDGHGIKMWQRAGFRTALISGRASNATTVRAEQLGIEHVQQGCKKKLPAFEKLLDDMDMNADEVVYMGDDLLDLPLVRRAAFGVAVANAVNELKEHADYVTDKPGGRGAVREVIELVLKSTGHWDELMQRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT4</accession>
    <name>A0A1U9NLT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68698">
        <property type="protein sequence ID" value="AQT68698"/>
        <property type="gene ID" value="STSP2_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01870"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22880" checksum="CE61C7E5C3D63F56" modified="2017-06-07" version="1">MISRTSKLTHSAYTIAKNGTNWEIKEAIDSNPVGLAIVQFGGPFHSPFHKKNNRAAASLINSKELVNVFNRDSGLVGMPALSHKRHIIAYLRHVLVCSDPEIEIPDGYPCIDGKPIFIQESGVFIYPERSASSYPNNCYFCSNKIKLNTPNGTKIIWQNKSKSRGSSIHAALCNRCGSYFVFESRRQATLYLQNTSLRLKKPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY2</accession>
    <name>A0A1U9NLY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin A1 protease</fullName>
            <ecNumber evidence="3">3.4.24.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iga_3</name>
        <name evidence="3" type="ORF">STSP2_01661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.13" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01661"/>
    <dbReference type="EnsemblBacteria" id="AQT68496">
        <property type="protein sequence ID" value="AQT68496"/>
        <property type="gene ID" value="STSP2_01661"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01661"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010740285" evidence="1">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="40459" checksum="440A8B3F0DA1EEC8" modified="2017-06-07" version="1" precursor="true">MKPKPSILVVLIITSLQTLAAGYSGGTGTANDPFQIATPSDWQQLCTTVNDWDNSFVLTSDIDLMAASPQPVGNLTTPFTGSLNGDGFTISGASLQMPDTNFIGLFGVINGGRISNLNITALNVSADRMSGGLVGQLAAGDVINCHISGTVAGTSDIGGLIGSSSGNVEYCSSSATVNDAAYTGGLIGTNDGTITRCSAACEVSGVGEAGGLVGRTGDNSVISSCWSTGSLVCSSSSVGGLVGLNRGIVQDCYSHASVAGTGTFKKYFGGLIGWNYSGSQCINSFSTGTVNGGTAPSYVGGLVGRNSASVTACFWNTETSGIPTSSGGFAKTTDQLMDIYTFTDAAWDMQNTWNMGHHQTYPYIRLWQSSDFNRDGIVDMQDLANLAQQWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM77</accession>
    <name>A0A1U9NM77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68828">
        <property type="protein sequence ID" value="AQT68828"/>
        <property type="gene ID" value="STSP2_02004"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02004"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012052743" evidence="1">
        <location>
            <begin position="26"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="712" mass="78013" checksum="7F18D91A4807B2A2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC6</accession>
    <name>A0A1U9NMC6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein STSP2_02248</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02248"/>
    <dbReference type="EnsemblBacteria" id="AQT69063">
        <property type="protein sequence ID" value="AQT69063"/>
        <property type="gene ID" value="STSP2_02248"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02248"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="10825" checksum="67625049B3432A07" modified="2017-06-07" version="1">MNGRLNITSQADGVHFTVKVVPGSSKTDLAGILGDMIKVKVAAPPEKGKANKCLTEFIAKLFGIRKTDVSVVAGQTNPVKQLCVSGISADKVVETFKSCGISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME1</accession>
    <name>A0A1U9NME1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="2">2.4.2.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnC_1</name>
        <name evidence="2" type="ORF">STSP2_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.53" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02183"/>
    <dbReference type="EnsemblBacteria" id="AQT69005">
        <property type="protein sequence ID" value="AQT69005"/>
        <property type="gene ID" value="STSP2_02183"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02183"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099621">
        <property type="term" value="F:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26120" checksum="6AF1ADFEC9E2366E" modified="2017-06-07" version="1">MTKTSPSISAFFPCYNEQENIEKLVRKTEEVLESLTDDHEIIIVNDGSVDGTAQIADSLAEEISSVKVVHHKTNSGYGAALQSGFEAASKELIFYTDGDGQFDVGELKDILPLIEDCDIVSCYRLKRQEGTIRKINAYCWGVLVNFVFHMKLRDIDCAFKLYRARVFENMPMKSTGALIDTEVLARASRRGFKIVQHGVHHYPRTAGAPTGASPAVILRAFKELFILRKDILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF7</accession>
    <name>A0A1U9NMF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69132">
        <property type="protein sequence ID" value="AQT69132"/>
        <property type="gene ID" value="STSP2_02319"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02319"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="30372" checksum="E4BBFCFCAAA35AAD" modified="2017-06-07" version="1">MKKNAGFTLIELLIVIAIIALLLAIMLPALGKVKQKAQSVVCRNHLKTLGLGNSLYAGSYDSSYVPAVDASVPDEPTWNTSQSFRELVGVEDDEGLEQWVMPDEYLCPTDKHFRNDAFWASTNLSVNRISYGYNMTDWGRDSHDPYNLSGNIAAGDFRGLKEKDVRRPSNKLMFIDAGDIWVRKEGGDYKQYWDVYGHDTDRYKTEAGMWWATYYRHSEGANIVFFDGHVEHMDKEDVFNYTDAGSRDYRVNDRLWFVNPMNKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI8</accession>
    <name>A0A1U9NMI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lacZ_4</name>
        <name evidence="8" type="ORF">STSP2_01986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68810">
        <property type="protein sequence ID" value="AQT68810"/>
        <property type="gene ID" value="STSP2_01986"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01986"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="333"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="7">
        <location>
            <begin position="728"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="885" mass="100568" checksum="BD2CEE1668FC4951" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK9</accession>
    <name>A0A1U9NMK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron hydrogenase 1</fullName>
            <ecNumber evidence="7">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.7.2" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02152"/>
    <dbReference type="EnsemblBacteria" id="AQT68974">
        <property type="protein sequence ID" value="AQT68974"/>
        <property type="gene ID" value="STSP2_02152"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02152"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
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        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="6">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="577" mass="62863" checksum="31AA4C3E3641F3B3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML8</accession>
    <name>A0A1U9NML8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02261"/>
    <dbReference type="EnsemblBacteria" id="AQT69075">
        <property type="protein sequence ID" value="AQT69075"/>
        <property type="gene ID" value="STSP2_02261"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02261"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="273" mass="31117" checksum="EE46C7C3F735FFB1" modified="2017-06-07" version="1">MVIAMGQFVVIKQQNKILEDVKMFKAKGFTLIELLVVISIIALLLAIMMPALGMVKEKAKDVICRTNLKNIQLASLMYAQNNDGKMPPYSFGNALWVNKLGAYSGEMDEVRYCPSTKIRKDTPAGSSWGGPREAWVWFYDGMEEPEQGSYTINTWFYSSGRFGADETRNYRSLDDTRRPGNVPIFADGIWIDSIVDDTDYVPDDYNLDDPTERYGGNMCVFITNRHKDHTNLGFADGSQRPVDFSELWSLKWHKEFDTVKEKTRDDGSPIYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP7</accession>
    <name>A0A1U9NMP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor RpoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02292"/>
    <dbReference type="EnsemblBacteria" id="AQT69105">
        <property type="protein sequence ID" value="AQT69105"/>
        <property type="gene ID" value="STSP2_02292"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02292"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="21865" checksum="78BA50125EB93E94" modified="2017-06-07" version="1">MDQQGQDNSVRDEKGREFVSLLTAQQARIYSYILSMVPRLNDADDILQETTGLMWEKFDSFEHGTDFLAWGKKFAYYLVLDYYRKKKKRNEFYYDHQLIAKLDRNFQRVSDSSKDYQTYLKGCVKKLKGQDRKLLQLRYFENHTAKNLASRFGCSVQYVYRNISRIHQLLLACIQKQVAGKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR5</accession>
    <name>A0A1U9NMR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68890">
        <property type="protein sequence ID" value="AQT68890"/>
        <property type="gene ID" value="STSP2_02067"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02067"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15178" checksum="09EDF808110F7CD4" modified="2017-06-07" version="1">MENLHNWLQAANAVIVIICQFLAMVVIMVGIAKATRIYFADVLTPGRSEAAVKQGRLELGYSFSLALGFLIGASILKTTLAPTWADIGQLAAIIAIRTILNYFLLHDIATQSREGQQLELWSLFHRGKHKDKPSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT5</accession>
    <name>A0A1U9NMT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69038">
        <property type="protein sequence ID" value="AQT69038"/>
        <property type="gene ID" value="STSP2_02219"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013387304" evidence="1">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="681" mass="77109" checksum="9CB5B2332617A4CF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV9</accession>
    <name>A0A1U9NMV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM/Cys-rich domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_02428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69239">
        <property type="protein sequence ID" value="AQT69239"/>
        <property type="gene ID" value="STSP2_02428"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02428"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="DUF3641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_SeCys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="PTHR43728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="DUF3641" evidence="5">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="335" mass="37072" checksum="B282A2FBE16C0F46" modified="2017-06-07" version="1">MAAPKEHYSDKSFQEIVSGISPALLKLDRLETLQVNLGNRCNQQCRHCHVQAGPRGNKIMTRGVMDSIVSFVKKHGDLTVDMTGGCPEMNPHFSYFMEGITEVVNHIIARTNLSVFLENDYDWVPKYYADHGVTIVASLPCYTQDNVDNQRGQGVFDKSIKAIRMLNKLGYGQEDNLELDLVYNPAGATLPPPQSDLEVDYKKHLINDHDIVFNKLFTITNAPIGRFRQILTEQDELDSYIAMLRENFNSEAAQQIMCRKLLSVDYRGIVYNCDFNQALGLPAIDGSGSVITMDNLESAMRGEIRIITGSHCFCCTAGAGSSCTGTLAGSKSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY2</accession>
    <name>A0A1U9NMY2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="12" type="ORF">STSP2_02042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02042"/>
    <dbReference type="EnsemblBacteria" id="AQT68866">
        <property type="protein sequence ID" value="AQT68866"/>
        <property type="gene ID" value="STSP2_02042"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02042"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="97"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1212" mass="134201" checksum="536378AC93CDAE7D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN20</accession>
    <name>A0A1U9NN20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsbV</name>
        <name evidence="4" type="ORF">STSP2_02500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT69311">
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        <property type="gene ID" value="STSP2_02500"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02500"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52091"/>
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    </dbReference>
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        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13324" checksum="D54676D72FF9C9D8" modified="2017-06-07" version="1">MEQSSPKIAVQYVGDVVLVVPTDEKLLEEPDIQALEDSILPLVEDGTGVELVISFENVKFLSSAVLGLLIRLSKKVYENQGKMHLCCIDQKIYEIFKITRLDKVFEIYDSRDEAVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF3</accession>
    <name>A0A1U9NNF3_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Xylose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylR_2</name>
        <name evidence="2" type="ORF">STSP2_02231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    <dbReference type="EnsemblBacteria" id="AQT69046">
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    <dbReference type="KEGG" id="alus:STSP2_02231"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="285"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="43480" checksum="E273D5860D6147AE" modified="2017-06-07" version="1">MKHIPRIGLLIETSRGYGQSLLSGIAIFSRLHGPWSFSRNLPFYRKSPEDAGSSPQLNLVDGIIAHTDDAQTLLPAIDLGIPMIVQGIKDVCQNLPTIIADDTAVGKMAAEHFLDRNFKNFAFCGFDEMYWSQLRKQGFGDAVQEAGYDLHAFAHPQANDKRWQENEQALLVEWLEALPKPVGIFACNDDRSQDIAEACMLAGLNVPQDAAILGVDNDELICELSEFPLSSIALSTEKAGYMAAELLNKMLSGDRIDNAQITIDPLYVVTRRSTDIFAMDDKEVATAARLIKESLHDTIAINDIADQVALSRRAIELRFRREMGCTINNYIQKERVARIKDLLLQTDWTVSQIAEKTGFSSATYMVQVFHKHMKETPLNYRKRHHPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS2</accession>
    <name>A0A1U9NNS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane biogenesis protein BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69384">
        <property type="protein sequence ID" value="AQT69384"/>
        <property type="gene ID" value="STSP2_02573"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02573"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012595037" evidence="1">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40660" checksum="C81CC8446576F859" modified="2017-06-07" version="1" precursor="true">MFKYLVVFAFIVLSAMAPSASAQTQSGMENESDWLVSNDLLQAGGMAMAWQINMPLKADEDIDRIFVFDDYAYVLTDSNFLFCINTKTGTPRFSLELASKGLPVCNPTYAENKLYFIIGNDLKIVDPAVGSIVESQELPAIGRSAYCGIAKTEEMLYVAGSNNRLTAINPETYIKSFQATADDDSPIYSFVASSDYLVFATTPGTVFAIDPLSPEKDWEFIGAEGLKAPLVDEDGSVYISSLDTKVYKLNISNGRSEWPIPFEAGSPLQKSVRLGQDVFYQYAGQSGFYAADKETGKAVWELKGGLEVLTEESGSAYIFTAPGVLTVMDNNAGEKLYSVNFSDVTDYAVNTEDKMYIANDDGRFMAIEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS3</accession>
    <name>A0A1U9NNS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-2-acetamido-3-amino-2, 3-dideoxy-D-glucuronate N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbpD</name>
        <name evidence="3" type="ORF">STSP2_02796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02796"/>
    <dbReference type="EnsemblBacteria" id="AQT69602">
        <property type="protein sequence ID" value="AQT69602"/>
        <property type="gene ID" value="STSP2_02796"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02796"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23768" checksum="6FF525CE3EE4BEB6" modified="2017-06-07" version="1">MTKDYFVHKTSIVDEGASVGEGTNIWHFSHVMKNARIGKNCIFGQNTCVSPDVIVGNSVKVQNNVSIYTGTVIEDDVFLGPSCVLTNVTNPRSQVVRRDLYEKTVIKRGATIGANSTIVCGIEIGRYAFIGAGAVVTQNVPDYALMLGVPAKQSGWMSRHGIPLKDPDENGVMTCPESGYRYKEVQPGKMKCLDLDEEACLPEEKSVGKAPYDDFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX1</accession>
    <name>A0A1U9NNX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase [NADPH] small chain</fullName>
            <ecNumber evidence="4">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gltD</name>
        <name evidence="4" type="ORF">STSP2_02608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02608"/>
    <dbReference type="EnsemblBacteria" id="AQT69418">
        <property type="protein sequence ID" value="AQT69418"/>
        <property type="gene ID" value="STSP2_02608"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02608"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="3">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="166"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="488" mass="53030" checksum="0152B2A6A48516C7" modified="2017-06-07" version="1">MTDDKKLLQELLEKHNNGDLKPKERYEIPPQGMPAQDATERRDNIDEVATGYTETQARLEALRCLQCKNAPCVAGCPVKIKIKDFVSAIADGQYQQALEIIKENSLLPSVCGRVCPQEVQCQEKCTVAKRFKDVDKAVAIGRLERFVADWGEENDSTPKIAPPTGKKVAVIGSGPGGVVVATDCRRAGHDVTVFEAFHKPGGVLVYGIPEFRLPKAIVEREIKGLEKMGVKFECNFIVGRTRTVKQLLEEDGFDAAYIGVGAGLPRFMNIEGEQLVGVYSANEYLTRANLMKAYQFGEGADTPIAVSKKVAVLGGGNVAMDAARTAVRLGAEEVYLIYRRSEAEMPARVEEVHHAKEEGIIFKTLQNPKRILGDGDGYVKSLECLKYELGEPDDSGRRRPVPIEGSEFEIDVDTVIVAIGNGANPLIGQTTPGLEMNKWGNIVVDEDCKTSLDGVYAGGDIVLGAATVILAMGQGRIAAAAMNDYLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP41</accession>
    <name>A0A1U9NP41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02695"/>
    <dbReference type="EnsemblBacteria" id="AQT69504">
        <property type="protein sequence ID" value="AQT69504"/>
        <property type="gene ID" value="STSP2_02695"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02695"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15131" checksum="DF91280643D60308" modified="2017-06-07" version="1">MKLCRPRPKPGMGVNIASLIDVFFLLIIFFMSVSQVTPRQMRIDLPSAEQVNEQSNALRKELVFSVTAGEDIHHLGERITADQFGNLVRNEAETAGTSNVEVHIRGDRTTDWKAVRGLLDICAKAGITGVKVGVIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP56</accession>
    <name>A0A1U9NP56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase EpsJ</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsJ_3</name>
        <name evidence="2" type="ORF">STSP2_02819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69625">
        <property type="protein sequence ID" value="AQT69625"/>
        <property type="gene ID" value="STSP2_02819"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02819"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="37910" checksum="46B80CDE542359E4" modified="2017-06-07" version="1">MTKPSSKPVSVILPAYNAAEHIQTAVSSVLAQTAPPQEIIVIDDGSTDNTAEIVKSFGEKVRYIHQPNAGVSAARNTGIKAASAEWIAFLDADDEWLPEKLEKQFALLDADQSLAFCSANYIRISHDRTRSAPDVDPEKCRTLTSSDNRFDSYYTAFANGITGHTDTMLIRKTILEQVGMFNESISRFEDLDLWFRIAAVTENFGFISEPLAIYTVENPESLSRSTCPIETYADFIRRNLAFAKQHDKLDQFTPCAAKLLRQWIRSMLFDARKNDIRLLLDEFHNLLPNAYIRNMKIMTACPNTTANLCRLASRIIRTFNLRSRVVAKPTPKQSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP72</accession>
    <name>A0A1U9NP72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69713">
        <property type="protein sequence ID" value="AQT69713"/>
        <property type="gene ID" value="STSP2_02909"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02909"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="548" mass="61862" checksum="5422524C7CA6E38F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA6</accession>
    <name>A0A1U9NPA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_13</name>
        <name evidence="2" type="ORF">STSP2_02969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69772">
        <property type="protein sequence ID" value="AQT69772"/>
        <property type="gene ID" value="STSP2_02969"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02969"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSG" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="110" mass="11849" checksum="939B57D78D9AFF11" modified="2017-06-07" version="1" precursor="true">MKRQNLKKGVTLIELLIVVLILAALSAIAIPRISKSATNAKAKACATNVDVLNSAIELYNADNGEYPDKLSTITTDISLFPDGAPVCPIEDAEYPDTLVDNRVDTSDHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC8</accession>
    <name>A0A1U9NPC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen fixation protein NifU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nifU</name>
        <name evidence="8" type="ORF">STSP2_02787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02787"/>
    <dbReference type="EnsemblBacteria" id="AQT69594">
        <property type="protein sequence ID" value="AQT69594"/>
        <property type="gene ID" value="STSP2_02787"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02787"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016217">
        <property type="entry name" value="N_fixation_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010238">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000375">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02000">
        <property type="entry name" value="NifU_proper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="NifU" evidence="5">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31656" checksum="0BDDC75CF0400D66" modified="2017-06-07" version="1">MWEYTDKVMDHFLNPRNVGVIEDADGKGDVGSLACGDALTLTFKLDENGRIADAKFKTFGCASAVASSSVLTEIIKGLTLEEAANVTNKDIAEKLGGLPDQKMHCSVMGQEALEAAIQNYYDKTKTTAPEKEGKVVCTCFGITDTEIRKVVEDNKLNSVEQVTNYCKAGGGCGRCKGDIEKILSEVRGDWIDRAKKKEQPPKRKKLTNIQKIRLVQETISDQIRPALRADGGDIDLIDVEGNKVIVAFRGMCAKCKMADLTMRDVVQAKLREFVSEDLVVEEEKDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD7</accession>
    <name>A0A1U9NPD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02999"/>
    <dbReference type="EnsemblBacteria" id="AQT69802">
        <property type="protein sequence ID" value="AQT69802"/>
        <property type="gene ID" value="STSP2_02999"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02999"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="48863" checksum="029C8116F3AF91E8" modified="2017-06-07" version="1">MMSHKNRLTFIGFFIICLCGFGYCEDGSASGSAAVSAENRDPLRPYDGPSVPGSDPSTLKGKVMTGYQGWFNCEGDGANLGWTHWAKNRNKPFEPNNIAVDLWPDVSEYDDDELYTTGFFHADGTPAKTFSSHNRKTVLRHFKWMQDYGIDGAFVQRFANGLHDKTMRYHKDVVLSSAREGANRYGRTYTIMYDLTGIPDEAITRVFDDWRMLRDKMHITEDPAFQHYNGKPLVAIWGVGFNNQIKRRPGFEQCRQLVKKFKADGCSVMLGIATGWREQNNDALQNPKLHDLLLMADVLSPWSVGRFGDLPGVERHAKKYWRPDAVWAKEHGVGYMPVVFPGFSWHNLKGAELDSIPRLKGKFFWSQVLAVKKAGCEMLYIAMFDEVDEATAIFKCSNNPPTTGGSKFLTYDGLPSDFYLRLAGRAGKLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ9</accession>
    <name>A0A1U9NPQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
            <ecNumber evidence="3">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69825">
        <property type="protein sequence ID" value="AQT69825"/>
        <property type="gene ID" value="STSP2_03023"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03023"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14788" checksum="6B7DA09FF0382FCC" modified="2017-06-07" version="1">MPDCIFCKIVKGEIPSNKLYEDEQVLAFLDIGPLSEGHSLVIPKDHFERFDQCPPDTLAKVIAAANKLAKAVAAATECDGYNVLCNTGRAAGQAVDHVHFHIIPRNQGDGLFDGWPAGEYEPGKAEKVADTIRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT9</accession>
    <name>A0A1U9NPT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69941">
        <property type="protein sequence ID" value="AQT69941"/>
        <property type="gene ID" value="STSP2_03141"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03141"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12756" checksum="8E4B2EC19B3667E7" modified="2017-06-07" version="1">MRDGDIKKYERRVVFGSGELFGVWRIDLNDQGAPDKQEAQRIEQLTGESTAWRCGDRIMTRITCPYRSNAKWSSRESCSTSCAFFHVEQCGVGTKAAKCGDHVIGFIDDEDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ38</accession>
    <name>A0A1U9NQ38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">STSP2_03042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03042"/>
    <dbReference type="EnsemblBacteria" id="AQT69844">
        <property type="protein sequence ID" value="AQT69844"/>
        <property type="gene ID" value="STSP2_03042"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03042"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9877" checksum="F3077FC9599D43B8" modified="2017-06-07" version="1">MDTSIQKRLKRGVVVSRSGDKSIRVQINYLVKHPMYGKYIRRRTKLGVHDPKNVANIGDTVDIAQCKPISKSKSWRLVSVVEKGIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ48</accession>
    <name>A0A1U9NQ48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69945">
        <property type="protein sequence ID" value="AQT69945"/>
        <property type="gene ID" value="STSP2_03145"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03145"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13380" checksum="B1BD7F6A99D200A5" modified="2017-06-07" version="1">MGLDFSHCDARWGYFSFDEFRKRLATQIGIDLDSMVGHGGTRPWEDVDDPLKPFLHHSDCDGELTVEECKQVYPRLEQLLQSWPDGDNPFSHKRKGMELVRGMKRAIAQGEPLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ80</accession>
    <name>A0A1U9NQ80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70091">
        <property type="protein sequence ID" value="AQT70091"/>
        <property type="gene ID" value="STSP2_03293"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03293"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12295" checksum="2A83D2714F123B29" modified="2017-06-07" version="1">MRKVSNKWAKRLSWYCLIPPAMYVLVRLINEEARIYAQDLASTLAGAAFLIGIVWGVYGIACLLSPSWVKCENCAFAELAEDTDKMYCRAKDFQYAIDYSCPKGRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ86</accession>
    <name>A0A1U9NQ86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Chorismate synthase</fullName>
                <shortName evidence="14">CS</shortName>
                <ecNumber evidence="14">4.2.3.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Shikimate kinase</fullName>
                <shortName evidence="13">SK</shortName>
                <ecNumber evidence="13">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">aroC</name>
        <name evidence="13" type="synonym">aroK</name>
        <name evidence="15" type="ORF">STSP2_02871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="14">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="14"/>
    <dbReference type="EC" id="2.7.1.71" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02871"/>
    <dbReference type="EnsemblBacteria" id="AQT69676">
        <property type="protein sequence ID" value="AQT69676"/>
        <property type="gene ID" value="STSP2_02871"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02871"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
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</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03058"/>
    <dbReference type="EnsemblBacteria" id="AQT69860">
        <property type="protein sequence ID" value="AQT69860"/>
        <property type="gene ID" value="STSP2_03058"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03058"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="6">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14263" checksum="862D1DAC0E992DD3" modified="2017-06-07" version="1">MSEQERTWSEDIKDLGDKIVGLTLMQAKELGDYLKEEHGIEPAAGGAVMMAGPAAGGEAAEEEEKSDFDVVLKEAGEKKIAVIKEVRAITGLGLKEAKELVDNAPKPVKEGVAKEEAEEMQKQLEAAGATVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ8</accession>
    <name>A0A1U9NQJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70202">
        <property type="protein sequence ID" value="AQT70202"/>
        <property type="gene ID" value="STSP2_03407"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03407"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20497" checksum="6E6C15D83D54D9CC" modified="2017-06-07" version="1">MAFLELAKTRQSVRSYKTDPVEREKLEYCLEAARLAPSACNSQPWQFVVVDEPELKEKVAKACFGKVISFNHFSLKAPAMVVLVAEKPNLTSKIGSVVKKKRFELMDVAIAAEHFCLAAAEQGLGTCMLGWFAEKPVKELLNVPKDRTVELIITVGYPAKEEVRPKKRKSLDEMRSFNTYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN0</accession>
    <name>A0A1U9NQN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PrkC</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prkC_2</name>
        <name evidence="3" type="ORF">STSP2_03246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70044">
        <property type="protein sequence ID" value="AQT70044"/>
        <property type="gene ID" value="STSP2_03246"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03246"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PASTA" evidence="1">
        <location>
            <begin position="927"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1491" mass="164620" checksum="D26DE280D48301FF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN1</accession>
    <name>A0A1U9NQN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative type I restriction enzyme specificity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03289"/>
    <dbReference type="REBASE" id="191344">
        <property type="entry name" value="S.PbaBD1III"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70087">
        <property type="protein sequence ID" value="AQT70087"/>
        <property type="gene ID" value="STSP2_03289"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03289"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="206"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="382" mass="42999" checksum="CCAE0810E085736A" modified="2017-06-07" version="1">MVKQNTTPDKVPPGYKRTEIGVIPEDWEVIELGSICERITTGRLDANAMAEDGDYPFFTCAREPYRIDKFAFDTEALLISGNGANVGYIHYYAGKFNAYQRTYVLNGFRVNIHFCKWFIDRNLQDRIRVEVKAGNTPYITMSTLSEMKIAVPECVPEQRAIAEALSDVDSLIGSLDRLIAKKRALKQAAMAELLTGKTRLPGFSGKWQTKRLGELAHIKTGSRNNQDKIEDGKYPFYVRSATVEHINSYSYEGEAILVPGEGGIGGIFHYINGRFDVHQRVYKISDFSSSTCGKFVYFAMVNSFGRYALKNTVKATVDSLRLPTFLNFVFAGPEDVAEQRAIAEVLSDMDAEIEALEDRRDKTRQIKQGMMAELLTGRTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ4</accession>
    <name>A0A1U9NQQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69950">
        <property type="protein sequence ID" value="AQT69950"/>
        <property type="gene ID" value="STSP2_03150"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03150"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="372" mass="42072" checksum="E2A4BA83E8EF0EFA" modified="2017-06-07" version="1">MAVENSKLKSKSKLKSKCFQAAEVLKHYSDGPVDVWDEQYGVETDDQRSALLGANAQILYSFFCEQVSLQASECYYAGQVEDLTANLAEHVEKIQQLEKQISEWRRATCANEPKNACSHGEIRDIFREHLAENLKVEIPTDKPIEQWIRGEFIRRENRIAEMSERITQERGRATKFERKMNEVRAELADAQVEIMELKGRRTEPTARGSGGKTEKPKKIGRPRKGNLDARFMKIPATASSQVPAAFGDAVRTSGRGSSVYRGACYYKLKGCWRAQLWVEDNVKTLGQYEIEEEAAAAVQRELSNERLAVEMEEFAQRKKAAFLKGRLDQFYAIETGLKESLGQWMCGGCGHNYEGSRPEKCVKCNGSSFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR3</accession>
    <name>A0A1U9NQR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03478"/>
    <dbReference type="EnsemblBacteria" id="AQT70272">
        <property type="protein sequence ID" value="AQT70272"/>
        <property type="gene ID" value="STSP2_03478"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03478"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117797" checksum="2B4767223A3B3BA7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS8</accession>
    <name>A0A1U9NQS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmGA</name>
        <name evidence="4" type="synonym">rpmG</name>
        <name evidence="5" type="ORF">STSP2_03065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03065"/>
    <dbReference type="EnsemblBacteria" id="AQT69866">
        <property type="protein sequence ID" value="AQT69866"/>
        <property type="gene ID" value="STSP2_03065"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03065"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6626" checksum="1A0D569280BA9809" modified="2017-06-07" version="1">MARSTKREYVWLECKTCGSRNYRTEVNVQGGTPKLQLNKFCKQDRKRTPHKIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT5</accession>
    <name>A0A1U9NQT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">16S ribosomal RNA methyltransferase KsgA/Dim1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03076"/>
    <dbReference type="EnsemblBacteria" id="AQT69876">
        <property type="protein sequence ID" value="AQT69876"/>
        <property type="gene ID" value="STSP2_03076"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03076"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21455" checksum="1A4FD7CFAB19FB29" modified="2017-06-07" version="1">MKKGQSHIVFLSKFFQRPRTIGAVAPSSRHLARQIVGLAGVSDSSRILEFGPGTGSFTREILRQKREEAKVLAVEMDSRLVVHLRKQFPDAVIAAGSAANACRIMEANGFGAADCIVSGLPWAAFDDELQESILNEAREVLKEDGVFTTFAYASMLFLPAAKRFRGRLERAFGSVEVSPVVWRNLPPAVVYRCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU1</accession>
    <name>A0A1U9NQU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70104">
        <property type="protein sequence ID" value="AQT70104"/>
        <property type="gene ID" value="STSP2_03308"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03308"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3410" checksum="73F54D7126B1B7F9" modified="2017-06-07" version="1">MIKGLGKYMMAYGKEFPNGLFCCFEMTSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX3</accession>
    <name>A0A1U9NQX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_03348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70144">
        <property type="protein sequence ID" value="AQT70144"/>
        <property type="gene ID" value="STSP2_03348"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03348"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012730665" evidence="8">
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            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="9">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23037" checksum="8ACBC91831CEA81B" modified="2017-06-07" version="1" precursor="true">MFRNKGAAIALLFAVTLCFTVIPAMAQAEESGSAVQGEDGSLLTDLRWSPYWVGAGIGVLSMFTFVLSDHPIGVSTAYARTAGMVQKLFQRRTVEENAYYQKFPPKVDWEWMFVLGIFIGAFLSAQLSGRFVLRMVPTVWQETAGPSGLLRWIFALVGGAVMGLGARWARGCTSGHGISGTLQLAVSSWIVLISLFASGVLTAMVLYYGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR41</accession>
    <name>A0A1U9NR41_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03491"/>
    <dbReference type="EnsemblBacteria" id="AQT70285">
        <property type="protein sequence ID" value="AQT70285"/>
        <property type="gene ID" value="STSP2_03491"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03491"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="30362" checksum="33D08546738FC4AE" modified="2017-06-07" version="1">MEKRKAFTLIELLVVISIIALLLAIMMPALGMVKEKAKNLVCKSNLRSISLACSIYGEEHNGKLMEYRAYQLFLRQLEPYVGNMDEIRYCPSTKINESNTEAGKNGWGSSTEAWWWWLDDTWEEPEFGSYGMNGWMYTYTDSMGYIVGGERGRMWGNLSAVKQASKTPFFVDAIWVDLWPMDTDTIPGTYKLDTGGGGYDAGGGSTGSPGNHIQRCVTDRHNGSVDMAFVDGHTENIKLAELWSVTWNKGWNVQHDVTRTDDTPIDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRK5</accession>
    <name>A0A1U9NRK5_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative membrane protein EpsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsK_2</name>
        <name evidence="2" type="ORF">STSP2_03544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT70338"/>
        <property type="gene ID" value="STSP2_03544"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03544"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MATE_fam"/>
    </dbReference>
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        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="432"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="518" mass="56974" checksum="6BD7A0EF8EFF9AAE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRQ1</accession>
    <name>A0A1U9NRQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xcpT_15</name>
        <name evidence="3" type="ORF">STSP2_03496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70290">
        <property type="protein sequence ID" value="AQT70290"/>
        <property type="gene ID" value="STSP2_03496"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03496"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="275" mass="31514" checksum="BD94ABABCC4D81EF" modified="2017-06-07" version="1">MKCGDRILRRKSAGGFTLIELLVVIAIIALLLSILLPSLRKVKEVARTVVCGSNIRQWGLIVDFYLNDNEGVFPDKDWDGDTLGDIHGQWWIQPFKQYMKGNSEILLCAQARKHPEDVPDSNVFQPSKETECWGSRDQEPAPTAGEWTWASYAPNAWIMSGAPSWAGRDFAENYWGRRSNIKRASNVPLFLDSRWVDVWPRETDRPEDELFDNSGNGSMTQLCHLRHGGYTNVVYCDGSVGKIKLTELWGLKWHRNYDTSNEMTRDDAEFPVWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG40</accession>
    <name>A0A1U9NG40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar motor protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00039"/>
    <dbReference type="EnsemblBacteria" id="AQT66901">
        <property type="protein sequence ID" value="AQT66901"/>
        <property type="gene ID" value="STSP2_00039"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00039"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MotB_plug" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24458" checksum="BBA7216890D67BC9" modified="2017-06-07" version="1">MARNRSKKPVEDDGDPGAPEWMVTFSDCMTLLLTFFVLLLSFATFDNGEFNSFSNAFGKGNKSVKAASGTPKDGMNEPQQIIPVEEVSKGSRVPSVTKDPTGNMVQQKRLTDYRNQKVFAVSSEDVFVAMGTVLNKDGKAILEDMAKFLELVPARVVISENDGAEPGKADKVGLSRACSVMEALVDKGVDRELISVTASNMLDDTHRRESRQLVITLLEEEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG79</accession>
    <name>A0A1U9NG79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">flhA</name>
        <name evidence="9" type="ORF">STSP2_00071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00071"/>
    <dbReference type="EnsemblBacteria" id="AQT66933">
        <property type="protein sequence ID" value="AQT66933"/>
        <property type="gene ID" value="STSP2_00071"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00071"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="708" mass="76534" checksum="6763709FDF1D8F89" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG97</accession>
    <name>A0A1U9NG97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeZ</name>
        <name evidence="2" type="ORF">STSP2_00097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00097"/>
    <dbReference type="EnsemblBacteria" id="AQT66959">
        <property type="protein sequence ID" value="AQT66959"/>
        <property type="gene ID" value="STSP2_00097"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00097"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13181" checksum="D33693ACEAE50F0A" modified="2017-06-07" version="1">MMGLKTKAAQAYFHAKNEFTTGPVEVDEMIKNDEPIKIIDVRGPQDYAQGHIPGAINLRKGEGFESLSKDKKSVVYCYDEDCHLATEACEELASEGYPVIELQGGFKGWKEHNFPIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ4</accession>
    <name>A0A1U9NGJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basal-body rod modification protein FlgD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgD</name>
        <name evidence="3" type="ORF">STSP2_00063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00063"/>
    <dbReference type="EnsemblBacteria" id="AQT66925">
        <property type="protein sequence ID" value="AQT66925"/>
        <property type="gene ID" value="STSP2_00063"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00063"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16390" checksum="077880E24A4D61CB" modified="2017-06-07" version="1">MSSINSMQSAQQLQMDYMRLLTTQLQHQNPLDPMDNEQMTAQLTQLSQLGQLEQMNTSFAQVLESTKLNYAGNLVGKEVSFMDYSRMGPNNVPGVKVLGIVEKVDVEGENVMLNVGQYDQSGSKVKTHTINMKEVDTIGFNVTDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN3</accession>
    <name>A0A1U9NGN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">STSP2_00233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00233"/>
    <dbReference type="EnsemblBacteria" id="AQT67093">
        <property type="protein sequence ID" value="AQT67093"/>
        <property type="gene ID" value="STSP2_00233"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00233"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10337" checksum="2F93E1885C4FCACE" modified="2017-06-07" version="1">MKIRPLGDKVIIERLEAEAVTAGGIVLPDSAKEKPQRGKVVNVGEGKAMKDGSRSEMQVKKGDEVIFASYAGSEIKVGDKEYLIMDESDIMAVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR0</accession>
    <name>A0A1U9NGR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ORF">STSP2_00263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00263"/>
    <dbReference type="EnsemblBacteria" id="AQT67122">
        <property type="protein sequence ID" value="AQT67122"/>
        <property type="gene ID" value="STSP2_00263"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00263"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="284"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="463"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="697" mass="78302" checksum="5EE311554980ABA1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW7</accession>
    <name>A0A1U9NGW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ktr system potassium uptake protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ktrA</name>
        <name evidence="3" type="ORF">STSP2_00312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67169">
        <property type="protein sequence ID" value="AQT67169"/>
        <property type="gene ID" value="STSP2_00312"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00312"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24551" checksum="5FA7D00E3772D927" modified="2017-06-07" version="1">MKRYAVIGLGRFGSKLAVSLAMSGAEVIAIDKERNIIDTIQDQVSHAVRLDSTDEDALRAQGINKCDTAIVGMAESGKAFESAVLTVVNLKNLGVPQIIARAQTLTAGQVFTAVGANEVVYPEIETAQRWAYRLLAPHIGEKIDFAPGYSMASVDAPPSFQGKSIMDLQLRQKYNVNLVAIKRSEDETAKKPEKSSIINVPLPDTIVKPGDTLMVAGSESDLAKLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH14</accession>
    <name>A0A1U9NH14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-length control protein FliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66890">
        <property type="protein sequence ID" value="AQT66890"/>
        <property type="gene ID" value="STSP2_00028"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00028"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="416"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="562" mass="58402" checksum="8A830EF62296709E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH32</accession>
    <name>A0A1U9NH32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UVR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00217"/>
    <dbReference type="EnsemblBacteria" id="AQT67077">
        <property type="protein sequence ID" value="AQT67077"/>
        <property type="gene ID" value="STSP2_00217"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00217"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18896" checksum="8B9F8CE1187DD818" modified="2017-06-07" version="1">MQCQLCKQNMATIHLTEISNGQRSETHLCEDCAQQQGLSVKAQIPLNELLSTLLASQPEAKEELTAAAEDADLGSATCPACGMTLDRFKKESLLGCPHDYEAFEDQLNPLIEKTQNGRTTHSGKVPEHIPEDNKTQIELINLRRRLEEAVKLEDYETAAEIRDKINHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH34</accession>
    <name>A0A1U9NH34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="7">2.1.1.182</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmA</name>
        <name evidence="7" type="ORF">STSP2_00386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00386"/>
    <dbReference type="EnsemblBacteria" id="AQT67243">
        <property type="protein sequence ID" value="AQT67243"/>
        <property type="gene ID" value="STSP2_00386"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00386"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35920" checksum="2F2C21B996EB5144" modified="2017-06-07" version="1">MQTKHEIQRLLASAGARPNKKLGQNFLIDLNLMRLLIDAADIRKNDVVLEVGCGTGSFTEGLAEVAGRVVAAEYDKILARIAMQQLQDAEHVTIVNTDILESKNKLAPQIVEELARAKAELGGRLLLVANLPYNAGTSVMANLVGGTGEGLQNRPEGAENAVFEGENGVLGGGEKVGGGVGEPGIGLVADAMYVTVQKEVAQRMVAEPGGKLYGILSILIGACGESEILRILPPSVFWPAPGVESAMVSFERQAGKAARIRNMSVFKEIVNLFMGHRRKMMQACTKFAKGSELGGITDWGDIFDEAGVNPQMRPEKVLPDEFVEIANACAVRLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH53</accession>
    <name>A0A1U9NH53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purE_1</name>
        <name evidence="3" type="synonym">purE</name>
        <name evidence="7" type="ORF">STSP2_00276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00276"/>
    <dbReference type="EnsemblBacteria" id="AQT67135">
        <property type="protein sequence ID" value="AQT67135"/>
        <property type="gene ID" value="STSP2_00276"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00276"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="17250" checksum="53B8AA4C9FC42B02" modified="2017-06-07" version="1">MATENKNPQVAVVMGSDSDMPVMESCINQLRDFGLTPTVRVISAHRTPAAADEFAANAAKNGIKVIIAAAGMAAHLAGSIAGRTELPVIGVPMQASTGPCGLDALLSTVQMPPGVPVASMAIGKAGAKNAAIFATQILALSDEAVAAKLSDFRQAQTQKVLDKDAALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH84</accession>
    <name>A0A1U9NH84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein, SPP1 Gp6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00259"/>
    <dbReference type="EnsemblBacteria" id="AQT67118">
        <property type="protein sequence ID" value="AQT67118"/>
        <property type="gene ID" value="STSP2_00259"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00259"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="515" mass="56989" checksum="43C5698C82547B74" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD8</accession>
    <name>A0A1U9NHD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67164">
        <property type="protein sequence ID" value="AQT67164"/>
        <property type="gene ID" value="STSP2_00307"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00307"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20550" checksum="2FC285F70DC147AB" modified="2017-06-07" version="1" precursor="true">MKAIRYRLVIMGLVFLGFTFFCGCDPSAACYVVVEANDLQDSSAAALLSEAEIDRAIEIVDKIMQSREDMQVPQWYIEQKPEGGRWDNMFRVYGARKGASLERVVFYLYKEREGSLLCFEAFEFGGVRNNPRALELQQTVYNRFVNEFGERRVWSCVSSWEDGDDCSRLYRLRDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF6</accession>
    <name>A0A1U9NHF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)-translocating NADH-quinone reductase subunit D</fullName>
            <ecNumber evidence="8">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqrD_1</name>
        <name evidence="8" type="ORF">STSP2_00506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00506"/>
    <dbReference type="EnsemblBacteria" id="AQT67362">
        <property type="protein sequence ID" value="AQT67362"/>
        <property type="gene ID" value="STSP2_00506"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00506"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22510" checksum="45C342D438813A34" modified="2017-06-07" version="1">MANDTNTKMKVFSAGFWRENPVLILLLGMCPTLAVTTGVNASLTMGLTVIFVLTCANIVVSLMRNLLKPHIRILMFTLTISTFVTIADLVLKAYLPDMSDKLGPYIPLIIVNCLIICRAEACASKSPIGTSIIDALGMGLGFTATLVALGAIRELFGTGKLMGFEILHTTANGGWYTPWAGMIMPVGAFVTLGLMLAGVNLVNRKLESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI1</accession>
    <name>A0A1U9NHI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">gmk</name>
        <name evidence="12" type="ORF">STSP2_00361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00361"/>
    <dbReference type="EnsemblBacteria" id="AQT67218">
        <property type="protein sequence ID" value="AQT67218"/>
        <property type="gene ID" value="STSP2_00361"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00361"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="11">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21346" checksum="01DC99532E59B34D" modified="2017-06-07" version="1">MPENANKKGNLVVISGPSGVGKSTICKEIVDRTDAFLSVSATTRSRGEGEVEGKNYYFLSRSEFEKKIQAGEFLEYAEVFGNLYGTPWGPVEKALDEGKTVLLEIDVQGGQKAKKLFKDAIMVFILPPKESELEKRMHGRARGEDRTSAEKRLQSAGNEIAQAWQSYDHMVINDDLEEAVTEIISIIEGKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL5</accession>
    <name>A0A1U9NHL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4-mannooligosaccharide phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00410"/>
    <dbReference type="EnsemblBacteria" id="AQT67267">
        <property type="protein sequence ID" value="AQT67267"/>
        <property type="gene ID" value="STSP2_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00410"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="319" mass="36701" checksum="3E4143E782E41E4C" modified="2017-06-07" version="1">MASFGREKLAQTLFRRYDGNPILTVENWPYPINSVFNPAATRFKGGIMLLNRVEDLRGFSHLTTAFSRDGLSNWEIDDFPTMMPESTTEEQTFGLEDPRIVWLEEQQQYAIVYTSFSEGGAVVSLAITKNFKTFARLGGMVPPEDKDACLFPRRFNGRFALIHRPIVRGEAHIWMSLSPDLKHWGDHRVLLHTRHGYWDGARIGLGCQPIEIPEGWLIFYHGVRRTTANQIYRMGIALLDKEMPWKVLRRSEEWVLGPREMYERIGDVGDVTFVSGAVVHEETNELFLYYGAADDKVAVAIADMDRLREYVMKCPEVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN7</accession>
    <name>A0A1U9NHN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67433">
        <property type="protein sequence ID" value="AQT67433"/>
        <property type="gene ID" value="STSP2_00580"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00580"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="729" mass="81171" checksum="E3FCC1438E33C8AD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU9</accession>
    <name>A0A1U9NHU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="3" type="ORF">STSP2_00529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67385">
        <property type="protein sequence ID" value="AQT67385"/>
        <property type="gene ID" value="STSP2_00529"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00529"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="17394" checksum="5379A122430EEB3A" modified="2017-06-07" version="1">MGRLLEESKVRFDEYLRDKNLRRSARRDKVVDAFLRTERHLSIQELYDLVRKKDKDIGYATVARAVGLMTEAGLCREVDFGEGLTRYEHEYGHEHHDHLVCTGCGAFVEIYSPKLERLQAKLVEEHGYVEESHKLNIFGICPKCQKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI37</accession>
    <name>A0A1U9NI37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component regulator propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00319"/>
    <dbReference type="EnsemblBacteria" id="AQT67176">
        <property type="protein sequence ID" value="AQT67176"/>
        <property type="gene ID" value="STSP2_00319"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00319"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188761" evidence="2">
        <location>
            <begin position="27"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="760" mass="82593" checksum="1F27BB9578F2C82F" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI77</accession>
    <name>A0A1U9NI77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ORF">STSP2_00781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00781"/>
    <dbReference type="EnsemblBacteria" id="AQT67633">
        <property type="protein sequence ID" value="AQT67633"/>
        <property type="gene ID" value="STSP2_00781"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00781"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="371"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="493" mass="55136" checksum="ABDE46985844C53E" modified="2017-06-07" version="1">MGLKLYNTLTRQVEEFEPVQEGRVGMYVCGPTVYGHAHLGHAKSYVSFDVLARYLRYLGYSLTYVQNITDVGHLTDDADEGEDKLAVAARKEHKHPMELAEFYTASYFRDMDELNCVRPDISPRASGHIPEQIALVKKLLEKGFAYESNGSVYFDVARFNEYGKLSGRKLEDMQAGARIDVNPEKKNPADFAVWKKAEPNHIMQWDSPWGMGYPGWHLECSVMSMKYLGETVDIHGGGLENQFPHHECEIAQAEAVTGKPFVKYWLHNNMVTVNGTKMGKSLNNFILCSELFSGEHELLSRGYDPLAVRQLILNSHYRSPIDFSDAALTSAQSGYDRITDAVVAVRKQMGNAAEGEIDAEVAKQLEEAKAKFERAMNDDLNTAVALSVMFDLVKLSNKLLEDEKTTKGTLAAVDGMFRRLGGDVLGIVKDEYAQAGAGDEELLDHLIGMMIEQRQQARKNKDFATADGIRDKLSEFGILLEDKPGGASTWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI94</accession>
    <name>A0A1U9NI94_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tilS</name>
        <name evidence="8" type="ORF">STSP2_00789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00789"/>
    <dbReference type="EnsemblBacteria" id="AQT67641">
        <property type="protein sequence ID" value="AQT67641"/>
        <property type="gene ID" value="STSP2_00789"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00789"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="476" mass="53154" checksum="6F2BFF6BA7D6FA6C" modified="2017-06-07" version="1">MNEFERKIADFVRSEGLIGAGERVLAAVSGGADSVALLRVLQAMRDEGAEFEVAVGHVNHNLRGAASDGDEAFVKVLAERMGVEVRSESVDTVGHAKKHRVSTETAARRLRMEGLGRMADELGCGLIATAHHMDDNAETVVHRLMRGTGYRGLGGIWPRKVFGSGRRYVRPLLCVRRREIVDYCTDKGVEWRHDHTNDELVYTRNRIRHAVLPGLEAESEGDLVRELFGLSTAARGMTERIEREAKRCWGRIVRAESGDRVVMDRAGFAELTRGVRQAVARRAIVRIGCGERDITRVHYESIFELAGNASGRIELPGGYEVVSEGDMVVFGKVREQREAVHPARQVLAVEGVTQFGIWEIRAEVLGADEVDMAAVEGNADRRVEYFDADRVEGEIMVRCREDGDRFRPIWGRGVKKVGKFLTDLKANERERGEVVVFEDSEGDILWVGPLRASEKAKVRADTRRVLRVEMDRAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI96</accession>
    <name>A0A1U9NI96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00655"/>
    <dbReference type="EnsemblBacteria" id="AQT67507">
        <property type="protein sequence ID" value="AQT67507"/>
        <property type="gene ID" value="STSP2_00655"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00655"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20568" checksum="0D93B0C46929B0E2" modified="2017-06-07" version="1">MAKQNKSVKWSDVKKVLSNRDRKELLALIKDLYSLNKQNKTFVQARYSLIDQVRPYKAIIKDCISIDLDRPIDLAGAKKAISQYRKAVGDHEGVLELMVFYVECGNDLTCEYGDINEQFYYSLESVFEKALKTLTQSDDDTVEKFLPRLDAVVEKAQGIGWGYYDTILSLLCDYFPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA4</accession>
    <name>A0A1U9NIA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ORF">STSP2_00799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00799"/>
    <dbReference type="EnsemblBacteria" id="AQT67651">
        <property type="protein sequence ID" value="AQT67651"/>
        <property type="gene ID" value="STSP2_00799"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00799"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019855">
        <property type="entry name" value="CRISPR-assoc_Cas1_NMENI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03639">
        <property type="entry name" value="cas1_NMENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="33613" checksum="91197A12AF929AA1" modified="2017-06-07" version="1">MIKRVVEISSARRHLSIKHEQLVISEGRQECGRIPCEDMGVLLVDHPAVTYTHSVFTKLLECGCAVVLCNGKHHPVGMLLPIESNTLQCERFRNQIDAKKPVKKRLWQQIVRAKILHQAKVISEDELAVSALKGMAERVRSGDPDNVEAQASRRYWGVFAEGIKFKRERFGGPPNNMLNYGYTVMRAAVARSLCCAGLLPTLGIHHRNKYNAYCLADDLLEPFRGFVEARVRVMCNEFEEVEELTQEMKAELLEVLYEQVEIGGYKGPLMVGLHRTAASLQRVFAGEGKCLELPKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII8</accession>
    <name>A0A1U9NII8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67558">
        <property type="protein sequence ID" value="AQT67558"/>
        <property type="gene ID" value="STSP2_00706"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00706"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38464" checksum="61AF6BD2807AD96A" modified="2017-06-07" version="1">MISLLLKILSSVAVAMILKLQAQRRGSRTILIASNYIVASLINFVLWQIKGFEPLSLSATSLAAITGVSYFVAFTLMISSIASVGAALTVAVSRLAIILPMVTSIFFYREIPTAIQIAGITLAAVAMYFFSQARPSNGSASKYVTLREGTILTLLFVCMGINAVSFKIFKENFGDFQMEGFITILFAVAAVFAWTYALAKKEEFRLSDIGLGLTLGIPNGLSSLFLMLALLSLPGIVVFPVNHAGVISLSAVAAILIFREKICRSTLIGILVAIAAIVLMTFQPKQQNAEPPAEPAPASTPDTPVSDPYNDPSPVRADRVRRIRPVYDMHWVRPARISPPAHRARQATVRPWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ1</accession>
    <name>A0A1U9NIJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase isoenzymes formation protein HypC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hypC</name>
        <name evidence="2" type="ORF">STSP2_00692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00692"/>
    <dbReference type="EnsemblBacteria" id="AQT67544">
        <property type="protein sequence ID" value="AQT67544"/>
        <property type="gene ID" value="STSP2_00692"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00692"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8981" checksum="FAD9125F168DA2DB" modified="2017-06-07" version="1">MCLAVPARIIELEDDKAVADAMGNKWNVRTTLIPDLKVGDFVLVHAGFAISTLDEKEARETWDLFKEIEEFDDNSNRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL7</accession>
    <name>A0A1U9NIL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67782">
        <property type="protein sequence ID" value="AQT67782"/>
        <property type="gene ID" value="STSP2_00931"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00931"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="13393" checksum="76C5E001615F302C" modified="2017-06-07" version="1">MHYINRSLAVVTVKQGFVDWLRGLGTGEDFSLEECNRSKTAILLPDFDDETQAERYIRENWEDIVRHEVVMRLADQSRMPEGMDYDRFCDWFGVEITGDVYDMMEDEIDREMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP8</accession>
    <name>A0A1U9NIP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">uppP</name>
        <name evidence="16" type="ORF">STSP2_00766</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00766"/>
    <dbReference type="EnsemblBacteria" id="AQT67618">
        <property type="protein sequence ID" value="AQT67618"/>
        <property type="gene ID" value="STSP2_00766"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00766"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798480" description="Undecaprenyl-diphosphatase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34420" checksum="3D227A7DC8833BBF" modified="2017-06-07" version="1" precursor="true">MLGKTNKMQSAFDSLRKPALIAAFFATALLVLPVFAAETPASAETPPAENNFSTFDAILLGVVEGITEYLPVSSTGHLLFLQKMLGLAETEQAEAAADSYAIIIQSGAILAVLGLYFKRVRQVSVGMFTGDPGRQIGINLIIAFLPAAIVGLLLQSTIKSVLFGPWPIVVAWLAGGIVILAWKRHPDKKASPADTILETMTARQALIIGLIQCIAMWPGVSRSLATILGGLLVGLPLVAAVEFSFLLGGITLGAATVYELVVHGSIVLEAYDPATAFVGFLFSLISAAIAVKWLVTYLKTHSMAIFGYYRIGLAIAAAAYLLWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR7</accession>
    <name>A0A1U9NIR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67823">
        <property type="protein sequence ID" value="AQT67823"/>
        <property type="gene ID" value="STSP2_00973"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14592" checksum="33321546560CA086" modified="2017-06-07" version="1">MKLDTYTYRLLVVYIIIVVVISLFPPFVGKKTSRDGEKFIGMHFMFSSIIKYSSDRQQTVSSYRTVDGEKVLTEEKTYYPKHSYASTRVDIGRLLCELVAVSAIFGWLVLRGVRQRINDEQTRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS3</accession>
    <name>A0A1U9NIS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rimO</name>
        <name evidence="11" type="ORF">STSP2_00550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00550"/>
    <dbReference type="EnsemblBacteria" id="AQT67406">
        <property type="protein sequence ID" value="AQT67406"/>
        <property type="gene ID" value="STSP2_00550"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00550"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="152"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="385"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="452" mass="50080" checksum="153B6BA2852C73B4" modified="2017-06-07" version="1">MAKRKKQKQISVGFVALGCPKNLVDSEKMLAHAGQEGFVLSGDPDNADVVVINTCGFIEPAKQEAIGAICQAVDQKKKGHVRRVVVAGCLAQRMGKELLDEVKGIDAIVGLDERDKIAKVIRNVAAGRGKKVSDQVSRLPEKVSDDRGRLLVTPGHWAYLRISEGCNRKCSFCTIPSIRGMFRSKDEDAVVAEAQELVENGAVELSVIAQDSNYYGKDKGVAHGLSKLLDRLEGIEGLDWIRLMYLYPAGVDDELIERIAASEKVLNYVDMPIQHINNDILRSMKRVDTKEKTVALVEKLRKAMPDVVLRTTVITGFPGEGEKEFEELLDFIKWAKFDALGCFPFYPEPGTLAAELPGQVGESVRQERADEIMRVQQDIAFEKCRELIGKELVCLVDEPLAERQQIGRYYGQAPHIDSVCIVINSDALPGDFVRAKVIDTQDYDLVVEPVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX0</accession>
    <name>A0A1U9NIX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67879">
        <property type="protein sequence ID" value="AQT67879"/>
        <property type="gene ID" value="STSP2_01031"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01031"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8953" checksum="E71905792E233052" modified="2017-06-07" version="1" precursor="true">MRAQKPFCVRRKFRKCLNLVLVNGIMCVWNFYRDLAWCNNKTGFCLFRDSIVKCIDFSEQNVRIMLVLWSGRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ04</accession>
    <name>A0A1U9NJ04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solvent efflux pump periplasmic linker SrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">srpA</name>
        <name evidence="4" type="ORF">STSP2_01053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67901">
        <property type="protein sequence ID" value="AQT67901"/>
        <property type="gene ID" value="STSP2_01053"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01053"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="73"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="41399" checksum="458F4F37AEACE15F" modified="2017-06-07" version="1">MKKILSSKRLGILLGSILLIGGILAVAFISKRRGHEEPPELIRPVKYTVVQEPFVAWRRKYPGRVKASIEVELAFQVDGPIIKFPVKSGDRVEEGQFLARLDPRDYLNSVESAQAEYDKSKTYLERIEKAVKTGAVSRTELTNAQAAFDVAKANLKTAEKALDDTILVAKFDGIVADTFVENFQNVKAKEPILSLQDISEVEILINVTEERVIVAKEGQDIRYAATFEYAPGRRFDVTLKEFSTEADPLTQTYEARFTMPNPEDIMILPGMTATVMEFPPEKKADKAQAFLVPIEAMVISEEGKYYTWSLEPYKEDLFSCKQTTVQAGDMVEDSVIIQRGLEAGQKIVTAGVHLIEDGQTVRLMGKQGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ06</accession>
    <name>A0A1U9NJ06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67767">
        <property type="protein sequence ID" value="AQT67767"/>
        <property type="gene ID" value="STSP2_00916"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00916"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012234084" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18704" checksum="3329D1E6B662DDBC" modified="2017-06-07" version="1">MNRTSILGLILFSFLPAIASANLITGDGIPLVQYNTLTGLVLVDTDGANVTGLGVDFYDSETGQVSEDVNHFFDNSPTNPLFAEYGGIIPEWRTGFVGETIYAELNGVRRPAGTLTPWAQISAGLTTDNFIGAKYWLEGSSRKYTDIQIVPEPATLAMLGIGTLAIRKNIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ74</accession>
    <name>A0A1U9NJ74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coenzyme A disulfide reductase</fullName>
            <ecNumber evidence="4">1.8.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdr</name>
        <name evidence="4" type="ORF">STSP2_00933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00933"/>
    <dbReference type="EnsemblBacteria" id="AQT67784">
        <property type="protein sequence ID" value="AQT67784"/>
        <property type="gene ID" value="STSP2_00933"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00933"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050451">
        <property type="term" value="F:CoA-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="467"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="827" mass="88971" checksum="3DC2C0EB829131B3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ79</accession>
    <name>A0A1U9NJ79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67992">
        <property type="protein sequence ID" value="AQT67992"/>
        <property type="gene ID" value="STSP2_01146"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01146"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6221" checksum="1322E2340A6A8516" modified="2017-06-07" version="1">MKIDQSKILTHSTSHHMAASALRTSKTDHKTLRGSAFMNMSLGMGMGSTGTKGARMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ88</accession>
    <name>A0A1U9NJ88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67798">
        <property type="protein sequence ID" value="AQT67798"/>
        <property type="gene ID" value="STSP2_00947"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00947"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8032" checksum="4794B875170D6E9E" modified="2017-06-07" version="1">MNLFLYLQGGAVEDLSCQIRVYEAVSGFKGRGFRVVRRVLNGCFGVIEAVFQVLRRGVESAAWLVWYICKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA0</accession>
    <name>A0A1U9NJA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67596">
        <property type="protein sequence ID" value="AQT67596"/>
        <property type="gene ID" value="STSP2_00744"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00744"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9895" checksum="8838CEDFDC1BC8E4" modified="2017-06-07" version="1">MADGIFTGYDSEGRLLEIFLTDPTKPLYGRDINITIKDAEKVPSHQGELICVLRHFLKSVQKKPVSDKQVDAMSLAELVDEALKYKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJI7</accession>
    <name>A0A1U9NJI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68089">
        <property type="protein sequence ID" value="AQT68089"/>
        <property type="gene ID" value="STSP2_01244"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01244"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="3">
        <location>
            <begin position="373"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="487" mass="55684" checksum="558CC565BFF53D8D" modified="2017-06-07" version="1" precursor="true">MNKRQSLIKISLILTGLTLIWGCSNDKAKPLASNDWVDSPERPNIIFLLTDDQRNDTLGCAGHPIVQTPNIDSLASEGVRFENCFVTTSICAASRASIFTSLHERTHGYTFGKPAVAEAYTLSSYPALLRQAGYRSGFIGKFGCSMKGSGEMFDYFETVPGPGYLDQPDGSKLESTEVMSNLAQKFIKDNDDRPFCLSVSFHASHARDRNKTPGKGHYPYPEWTSELYDDVSVPSPGLSDPIYFEILPEFLQTSMNRKRFYWRWDTPEKYQTNMRSYFRMISGIDKVVGQLRHLLKELNIEDDTIIIYSADNGYYMGYRGFAGKWTHFEQSLRVPLVIYDPRMPDKFTGQSVDPMVLNLDFAPTILELGRVEVPEHYQGRSLLSAMSGASSIDLEKRDSIFCEHLMDHKDIPKWEGVRTKQYKYARYFEQNPAYECLYDLNVDPTELHNLVLHPDYQTILKQMRSKTDDFVKQYEIKGVVPQNVKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK6</accession>
    <name>A0A1U9NJK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_00909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00909"/>
    <dbReference type="EnsemblBacteria" id="AQT67760">
        <property type="protein sequence ID" value="AQT67760"/>
        <property type="gene ID" value="STSP2_00909"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00909"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
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        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="30368" checksum="97831E80B8F92ECC" modified="2017-06-07" version="1">MHRLNRQIRFSVNPFLEQTPRGSNSFASKPAGEGLAVFLSLWVELCSDLDPDTGFVVNVAEIDTIIRRYGIPVIAGRITERFRRGAHTSLTDLTEILEDAWAAIEDRFDEVTLHSLALDLNPYRKISIISEDAEMIYFTEKFDFAASHQLWNTKFSDEQNFQHFGKCANPSGHGHNYIIEVTVEKPAASPEFSIADYEKVVTDEFIAKVDHKNLNSDVDRFAELNPTVENIAVYAWDCLKDKFATARLAHVKVWESDRTYCKYSGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS2</accession>
    <name>A0A1U9NJS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68171">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5826" checksum="D2AEBC215F545EEF" modified="2017-06-07" version="1">MLQKNNTFFEIVIIGHKSLTYKAIHPYVVGVVHNFIAWVTYDTRNSPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT7</accession>
    <name>A0A1U9NJT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67850">
        <property type="protein sequence ID" value="AQT67850"/>
        <property type="gene ID" value="STSP2_01002"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01002"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="42333" checksum="0096944050E71ED8" modified="2017-06-07" version="1" precursor="true">MSGKVKFRVAVIAAVLCFAGFWGGAGFAVEAVEEAGSRTQDERADAVVGTGLEGVEFVEVEKPYTVGKDSVMDRGPIEPQFMARFHLKYSLGIIEDEFEDKAGEMPSGERFSDEQKKYLKYCDATSSTTGFRPRIEGYRQWRLYAVSERDVKLMVRAFFEYLDYLRRGQIDSLKEQKEGLSGEIERLEGDKKQKQEELSVLEGQLEEVKAESIYTESDEAGQAVGRLTSRMEELKLKIAGLEAKGLAAARAVATFTGMIEEERYADIKTELLKAVVEYEKKKADVQGELSAASGEYRLAEEMRKAASEFARLPGRMDRLQHSIRAFDSELKDERERLERTERSLKRAVEGDGKPQVYDDKIEVFSVEISARHGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX5</accession>
    <name>A0A1U9NJX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="3" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68209">
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        <property type="gene ID" value="STSP2_01365"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013047084" evidence="1">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44646" checksum="BEC8D4615C38E4E8" modified="2017-06-07" version="1" precursor="true">MSKPTKLMMIAILAATLSAPAWADSRAIDLKPEKMTSAQGFRPAFVRPEPAPTEDLTINAEFQASDQFYFNFTYGPDEDKIYSAVLDKQGGARAGVGLLYIDLNNDEILDPEKECITVLVGASYGSPPVHVPLSGFKDGSTRHVALAFNSSKVPDGEYVITAQLTSLTRFEGTTEFAGKKTKIALCDNNGNGTYNDINTRDVATSNDVVLVDTDSDGFFNMSFDSPEMFELNRYVKVHSDWYSFEPSPDGKTLDIQTEDPETGIVIAPDNIDYLELHSPNQDLKLTFTPNNRHVEALAGEYNLAEVRFAAKDDNGRQWFARAYDTSTQSLNFEVKPDEKIELPDLLPLKVSVEPQFKSNGKEIVFEPHTTTANGLQISVFGGDVPSVILKDPDGKILAKPKFEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK47</accession>
    <name>A0A1U9NK47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sialidase</fullName>
            <ecNumber evidence="3">3.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nedA_2</name>
        <name evidence="3" type="ORF">STSP2_01342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01342"/>
    <dbReference type="EnsemblBacteria" id="AQT68187">
        <property type="protein sequence ID" value="AQT68187"/>
        <property type="gene ID" value="STSP2_01342"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01342"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052794">
        <property type="term" value="F:exo-alpha-(2-&gt;3)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052795">
        <property type="term" value="F:exo-alpha-(2-&gt;6)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
        <property type="term" value="F:exo-alpha-(2-&gt;8)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888759" evidence="1">
        <location>
            <begin position="22"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="399"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="718" mass="77678" checksum="7DE14688A23C5B77" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK80</accession>
    <name>A0A1U9NK80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68148">
        <property type="protein sequence ID" value="AQT68148"/>
        <property type="gene ID" value="STSP2_01303"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01303"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323962" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5988" checksum="CC90C781739C5F24" modified="2017-06-07" version="1" precursor="true">MKLTKSITTTVGILLLSTFALLLQGCQCPCEGEEGFSQPEENVLQYTGDLPDQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD1</accession>
    <name>A0A1U9NKD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADP-reducing hydrogenase subunit HndC</fullName>
            <ecNumber evidence="13">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hndC</name>
        <name evidence="13" type="ORF">STSP2_01433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.12.1.3" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01433"/>
    <dbReference type="EnsemblBacteria" id="AQT68275">
        <property type="protein sequence ID" value="AQT68275"/>
        <property type="gene ID" value="STSP2_01433"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01433"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="597" mass="64941" checksum="02B6DA7EE2203EB9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF9</accession>
    <name>A0A1U9NKF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">STSP2_01582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01582"/>
    <dbReference type="EnsemblBacteria" id="AQT68422">
        <property type="protein sequence ID" value="AQT68422"/>
        <property type="gene ID" value="STSP2_01582"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01582"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="47485" checksum="C9F38AA80375472F" modified="2017-06-07" version="1">MAKKSGDGRKVEVCSFCGRSKKQVDAFVEGPGGVFICPECIDLCYNIVRQERRRQKGSSLVMQDVPKPREIKEFLDEYVIGQDEAKKCLSVAVHNHYKRLMHADMEDQEVEIEKSNILLIGPTGSGKTLLAKTLAKILNVPFAICDATTVTEAGYVGEDVENFLLRLLQSADYDVEAAQRGIVYIDEIDKVGKTNQNVSITRDVSGEGVQQALLKMLEGTTANIPPQGGRKHPEQSYIQMDTSQILFICGGTFVGLDNIVKQRLGKRMIGFGSEQKPVNDDEQNEYSQTISKVTAEDVIQYGMIPEMVGRLPIITTLNSLDVDALVQILTEPKNALVKQYKKLFELENAELEFTHDALQLLAKRAIERDTGARALRAITEELMIELMYHLPEQPENGKYVITEAVIEKREDLFEQKQQARKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK1</accession>
    <name>A0A1U9NKK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacillibactin transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">btr</name>
        <name evidence="3" type="ORF">STSP2_01426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68268">
        <property type="protein sequence ID" value="AQT68268"/>
        <property type="gene ID" value="STSP2_01426"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01426"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="31626" checksum="50BAB674A006C622" modified="2017-06-07" version="1">MFEQFATAHGPTTVASLNLNTVWRVDADPTYDIHCDFSRRTSQSLNPLGGQGFIAVRTLDGVGRLYLEDQEPLDLPANTLAVTHWNNLCRYHCRQKNWNFWWFEFFLSGPLHAPLHTCLHIPSSPDELTQLETIFTLLRKQSASDRHLASAQFTHMFYSWLAHYHGKTGESPYKADIDSLIEAIYSDLGRNWTVSEMAAAANMSERNFRKVFAQITGQGPKAFYDNIRLSMAREMLRLQNSSVKQVANTLGYSSEFHLSKAFKKKFGYPPLKAKLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM9</accession>
    <name>A0A1U9NKM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisD</name>
        <name evidence="9" type="ORF">STSP2_01525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01525"/>
    <dbReference type="EnsemblBacteria" id="AQT68365">
        <property type="protein sequence ID" value="AQT68365"/>
        <property type="gene ID" value="STSP2_01525"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01525"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="437" mass="47306" checksum="3BF192E906151082" modified="2017-06-07" version="1">MKCNFEDILLLSSEQNFEQKIENLRGAILDAAYWPDGDDRHGALDNIIKQVKDRGDDALQEFGSRFDGADLMPADFRVTAEELKAAHSSIDGDLLKAIRQSIDNVRKYQSEIFVGDKNSHPGIKYTPISRVGVCVPGASAPLPSTVIMTAVPAQVAGVKEIAVVSPPRYKGNIHPVILAACHEIGVTEVYKLGGAHAVAALAYGTDTIERVYKIVGPGSTWVQLAKRMVFGLRVDIDSIAGPSEVLVVANKDANPDWVAADMLSQAEHAPGSAIVFTDSQRMGHAVLESLSEQVEKLDRSEDTIRCLKEYSGVAVFDSMEQVIEHTNDFAAEHLQIQCGGKSREVADRIDNAGAIFIGPYTPVAVGDYWAGPSHTLPTGTSAKFFSALSSNDFVKSTSIIEYDQKKLAENADDIVRLAMTEGLDAHAKSVKIRLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN7</accession>
    <name>A0A1U9NKN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rex_2</name>
        <name evidence="6" type="synonym">rex</name>
        <name evidence="8" type="ORF">STSP2_01456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01456"/>
    <dbReference type="EnsemblBacteria" id="AQT68298">
        <property type="protein sequence ID" value="AQT68298"/>
        <property type="gene ID" value="STSP2_01456"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01456"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20580" checksum="68E5EAC0412D6DB4" modified="2017-06-07" version="1">MYFRALVFLEKNQKDYISSSELAEFVHIKPPQIRKDFSYFGAFGTKGIGYDIKNLINEIQSILKLDSPQKAALIGAGKLGTALCLFPGFKAYGFEISAIFDKDPDKIGKKIGNTTIEDVATVDSLTQRNIKLAILAVPANTAQSTTAELVQAGITGILNLSPCYLDVPPDVKVVTIDIAMELGALPYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW2</accession>
    <name>A0A1U9NKW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">STSP2_01739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01739"/>
    <dbReference type="EnsemblBacteria" id="AQT68571">
        <property type="protein sequence ID" value="AQT68571"/>
        <property type="gene ID" value="STSP2_01739"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01739"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9639" checksum="D7DC2B68686A7D94" modified="2017-06-07" version="1">MLDSISHLQAFFGLPGGIEWIVVLVIAVLLFGRRLPEIARGMGKSITEFKKGVKEGHDDITKAIEDADEEEPVVDSEEKTEEAKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL94</accession>
    <name>A0A1U9NL94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01669"/>
    <dbReference type="EnsemblBacteria" id="AQT68504">
        <property type="protein sequence ID" value="AQT68504"/>
        <property type="gene ID" value="STSP2_01669"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01669"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888760" evidence="2">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="323"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="642" mass="67787" checksum="3FF68D51E8D4BF77" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF2</accession>
    <name>A0A1U9NLF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose metabolism transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR_1</name>
        <name evidence="2" type="ORF">STSP2_01933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68761">
        <property type="protein sequence ID" value="AQT68761"/>
        <property type="gene ID" value="STSP2_01933"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01933"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="43414" checksum="E0F3E5ED53603E15" modified="2017-06-07" version="1">MNRIANIQLDKNQNKSNPLYQQIRREVQKRIDTNEISAGDVFPSITFLAKEWNVAYRTIKSAFELLEQDGVVSLHKGKCIVANDGSGNGISSQTFAVSYITCHHDDPYYAIASSGIRRFMLEKGIEYAMMDVGNSRRSFLEAIENPGPDIDGLLVLPFELPGYGEAVQRAIDAGKKVVFLDRVLPGVEASSVECDHFSIAFDATTHLLELHGRPVYFLGFADKPSGARDWYKGWSRGMQAHNHFDLEPYFFDFLVGEQELASTLDVGLEYSIKAATRLFSTRKDDVYCIFSGNDFIARGIYIAAENFGLQIGKDVFVVGSNDMPFAAKMQVPLSSVGTVPSAEQLGYQAAKLLYEHLTGAKKNPVRQLLPVELKARQSSLGVGINKIANFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLL7</accession>
    <name>A0A1U9NLL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01897"/>
    <dbReference type="EnsemblBacteria" id="AQT68725">
        <property type="protein sequence ID" value="AQT68725"/>
        <property type="gene ID" value="STSP2_01897"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01897"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021341">
        <property type="entry name" value="DUF2958"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11171">
        <property type="entry name" value="DUF2958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="32217" checksum="111AAD729739F7E4" modified="2017-06-07" version="1">MAWRPNEQFIEGVLDNTRQGKITGWMKFAGIEEKVTFDLDGNFHRDIRGSKVLLRGDGEACDRGKATSRMQGFSMTQKGKAGDMTAGLQPADYVEYPYFEWYSQDNGRVVIELNPDQVELLTRPIPACESDPIDRKEQNQNLTEFVSSTAEILTATEKTSTRAQANNRIRGMELLTEDLREKLPPLGSQDGKGGKALAHCKLFTPDSSFTWWILEAEPVKDRAGNVIDYQMFGLVEGHCKELGYISLQELEELRGPLGLPVERDLYFRPTTLDQIAPEMFKSSQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR3</accession>
    <name>A0A1U9NLR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68678">
        <property type="protein sequence ID" value="AQT68678"/>
        <property type="gene ID" value="STSP2_01848"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01848"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="40688" checksum="1D3B8939C33A116D" modified="2017-06-07" version="1">MISRERVLLALNHIEPDRVPFFYRDVPEAEFHVLKELGLSSRDELLEYLGVDFRWVGPGYVGPKLFDPETGIKRDIWGIEYKYVKLGERNGYWETVSNPLAECKSVEELEEYEWPRVEWFDFSVVTEKVRKYKDYAIMTEPGFASPSLFQCPVQGLLGQERAFMDVISDSEFFEAMVEKVLEFQLPFIDMMLEAGGGRIDLFRIGDDFGTQRGLLMSPVQWRKALRPGLKAMCELAENHHAHIYMHSCGAVRDLIPDLLELGVEVLDPLQVTAHGMVPAELKEAYGDKLCFSGGVDEQHLLREGDERAVCESVVELLDDMAKGGGFFIGPTHNFEADIPVGNILAMYRAAGDWSQSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR9</accession>
    <name>A0A1U9NLR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">thiL</name>
        <name evidence="5" type="ORF">STSP2_02069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02069"/>
    <dbReference type="EnsemblBacteria" id="AQT68892">
        <property type="protein sequence ID" value="AQT68892"/>
        <property type="gene ID" value="STSP2_02069"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02069"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32368" checksum="572665725E906CC3" modified="2017-06-07" version="1">MSGQGEDKVTSWFAQQSRAREERFPIGIGDDMAQVNMGGGSVLVTTDMLLDGVHFDLASAGAEQVGYKAMAASLSDCAAMATRPVCAVVAVALPTGFGEDKLKELHAGIVRAGDMFDCTLIGGDITAWRDNAGRFVINVTMLSECVDCVEPVKRSGAKVGDAVCVTGELGGSIAGKHLTFVPRVEEAIEIARAADVHAMMDVTDGLVKDLSRICAASGVGAIIEAERVPMTHAAKEGNDPLEAALYDGEDFELLFTVSAEDYETLAGEQSIKAGITRVGLITDSGRIELQRGRDREVLDVKGYDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS1</accession>
    <name>A0A1U9NLS1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein STSP2_01600</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_01600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01600"/>
    <dbReference type="EnsemblBacteria" id="AQT68436">
        <property type="protein sequence ID" value="AQT68436"/>
        <property type="gene ID" value="STSP2_01600"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01600"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="315"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="643" mass="72922" checksum="7AE6A4E7822C5C02" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW4</accession>
    <name>A0A1U9NLW4_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Type II secretory pathway, component PulK</fullName>
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        <name evidence="1" type="ORF">STSP2_02076</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68899">
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        <property type="gene ID" value="STSP2_02076"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02076"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42154" checksum="86429C8D72169562" modified="2017-06-07" version="1">MVKLIRQNRTNEKGAALLVVLFVVMAATVLSIGFLSKADSELASGSNFIVRTQMDSVAQSGLEHAKALLSNPQTVDTSVLDYWTGGTGLQIESGDDYYDVTVTRDATTAAYEYVYDITSEAYRLNGSDKVGRSNVQGRLRLHPVIAYWQHDSQTISTAMTINGSTYVWSDCRLDGTVNGDAYAAGQIYGTGTLNGSEHEYEADPLDLPGLSSSDYQMSYYYDGGGAYSVTSIANSYTGSFASAGMNNPAKVYYCSGDLALTDIVGTIQGTIVVSSNLRISSGCSFTIDPVKNMPALIVGDEIHIEGSDQSIAINGLVQVADHIDMLGKTNVQFQVDGAMYLLSDGIKNLWGSGSSVTVTADPVAASVEIWSSTENSRLWSPVGGAVFEAISRPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX7</accession>
    <name>A0A1U9NLX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68933">
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        <property type="gene ID" value="STSP2_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02110"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR013424">
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    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143325" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="135"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32842" checksum="1E488055760C8109" modified="2017-06-07" version="1" precursor="true">MKTKRMICLMALLMVTCSAVASAEIVHHWKMDAWSGDTLYVGGNPVTHGIVDSADAPGQGTIAGNSGDPNPAHDPLYLWGPMEGAGADAISSDVAPSAMLNGITSTGSYNFNHVIDQGGNMFYAADQFGNEYDSGSFTAELFFKSLDNTGGTETLLWSKEGHAASHIQLSTGASGTGGLEFWGWDGTGFASLTVTTDDRQAGFQDGLWHYVAARYDTDTNEMSLQVYSEDGSAYSKTQILDNDMILSGGNNNIIVGRQEGEVNRFAGLIDEVRLSTHAMDDAELMAIPEPATVALLGLGGLALLKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMF5</accession>
    <name>A0A1U9NMF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apu_9</name>
        <name evidence="3" type="ORF">STSP2_02288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69101">
        <property type="protein sequence ID" value="AQT69101"/>
        <property type="gene ID" value="STSP2_02288"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02288"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="780"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="954" mass="101663" checksum="BB67CCAAF5B00A02" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK2</accession>
    <name>A0A1U9NMK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01908"/>
    <dbReference type="EnsemblBacteria" id="AQT68736">
        <property type="protein sequence ID" value="AQT68736"/>
        <property type="gene ID" value="STSP2_01908"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01908"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="369" mass="42226" checksum="07C423B5809C1D54" modified="2017-06-07" version="1">MDLTEYVQRQKHVVAQQSRAVRDFTVFDYNYIPEKPFIRSESKQIIDAMLRFDVSGIATNFAVIGSRGSGKTLTMKYLARVVPAQTDLSMRYVNCRHHNTSFKILARLLNKRCTGLSLDKLFEMFSESITGKTVFVLDEVDLMSAKDKNRDILYLLSRSEKPVMVIMLSNNPHLLRELDAASKSSLQLVQMHFANYNAEQINAILLERAQKGLVSYDYTEVSEIAAMTTKKTNSDTRVAIKTLYYNVTEPQKSVESCFENARKDIVIDVINDLSDQNLLILTAAAQNKSDLTKNIYDLYCRLCRSQCEKPFSYVYYYSNLGYLQSIGLIALVSTKFGRTYTNRVVLTFNHSILFDTCRLRFSRVPAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN0</accession>
    <name>A0A1U9NMN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogen regulation protein NR(I)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glnG_2</name>
        <name evidence="9" type="ORF">STSP2_02172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT68994">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02172"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="473" mass="52345" checksum="592EB94488F0E3DD" modified="2017-06-07" version="1">MERILIVDDDSGIRSELVSIVSSPGREIIEASDGSEALQVLESEMFDLILSDVRMPGMDGFELLAEIRQRWTNLPVIIITAFASTDTAVQALRGGAYDYITKPFSIDDIRNIVSHALEANRLFNEVSYLKGRLGERYSMDNIIGQCPAMQKVFDTIMRVAKAPCNILITGESGTGKDLAAQAIHEYSSRSQNHLVTIDCGSIPEGLLESELFGHVKGAFTGAVSEKEGLVQSANGGTIFLDEIGDMPLSLQVKLLRLIQNRHVQKVGSTKREQVDVRILAATNANLAEKVRNKQFREDLFYRLNVVEIHLPPLRSRGGDVLLLMSYFLKRYSEALGREVCKVDESVKRAFGKYPWPGNVRELENAVERAVTLCDGSLIRLEDIPGNIAQWQNESGAVSGTLSERVDHFEKQCLIGAMEAEEFHAAGAAERLGISLATLYRKLKKFDIPVASTGIVEVERSNTGQTQFTRGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU8</accession>
    <name>A0A1U9NMU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ_2</name>
        <name evidence="1" type="ORF">STSP2_02012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02012"/>
    <dbReference type="EnsemblBacteria" id="AQT68836">
        <property type="protein sequence ID" value="AQT68836"/>
        <property type="gene ID" value="STSP2_02012"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02012"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18083" checksum="C347344B6B88098E" modified="2017-06-07" version="1">MRWIWIDKFLEFKSGESAVALKNVTLAEEHIHDHFPGYPTMPECLMIEAMAQTAGILVGEARKFAEKVILAKVKKAKFYDCVVPGDTITLHAQIESLADEAASTVGKIMRGEETIAEVNLMFSHIDQNLGGLEFPEENFVFTDMFESLITGFTEHNVTEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ2</accession>
    <name>A0A1U9NMZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome hibernation promoting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hpf</name>
        <name evidence="3" type="ORF">STSP2_02052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02052"/>
    <dbReference type="EnsemblBacteria" id="AQT68876">
        <property type="protein sequence ID" value="AQT68876"/>
        <property type="gene ID" value="STSP2_02052"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02052"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13016" checksum="D40AD4462B7B8D2B" modified="2017-06-07" version="1">MLFTITGKHLDVTEAMKAHAEEKTAKLPRYFDGINQVEVVIEGNEGGRTSVEIIARGEHNNIFIAKEAGDDTYACIDIVVHKLQRQLRKKKQKQRNNKHIPGPSAAGIPPESEEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMZ3</accession>
    <name>A0A1U9NMZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline-sulfatase</fullName>
            <ecNumber evidence="4">3.1.6.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">betC_3</name>
        <name evidence="4" type="ORF">STSP2_02285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.6" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69098">
        <property type="protein sequence ID" value="AQT69098"/>
        <property type="gene ID" value="STSP2_02285"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02285"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047753">
        <property type="term" value="F:choline-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="363" mass="41106" checksum="2B70647CF6E8EEE2" modified="2017-06-07" version="1">MRINHNAYNNLRIPSGERTFADAFNDGGYRTSYVGKWHLGGTGNDPVPEYNRGGFTDFIGYENYNDFIDGVLFFDENGDYTPTNDHRTKKTTDIAMERLAGLVDEQFAMVVSYVNPHYPEQPTLKYEKMYENLMPTRRPNCTTDPNFDPYTPISAGTHTVTDGRDDYRYDLDQYLRQYYAMITQLDANLGRLFAELKRLGLWDSTVIIFTADHGDMQGSHGLKNKTVHWEESTRVPFIVRAPGGVKGQVLDYLVSAGIDPFPTCLGFAGLPQEPTTEGNNIAPLVMGERQLDAVPVFSELGGWAMIREGDFKLTVSKSDWQPDYLFDLANDPYEMTNLVNNSGYSSIESDLLAKLIEWRDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN25</accession>
    <name>A0A1U9NN25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">corC_2</name>
        <name evidence="12" type="ORF">STSP2_02331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02331"/>
    <dbReference type="EnsemblBacteria" id="AQT69144">
        <property type="protein sequence ID" value="AQT69144"/>
        <property type="gene ID" value="STSP2_02331"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02331"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="421" mass="46653" checksum="7257F5A80C49814C" modified="2017-06-07" version="1">MKAILANLGQILLMIALLAGSGFMSGSETAFFNLTRRQVQAFRQSSHRLHLAAAHLLGRPRILLTSLLFANMTVNVLYFAISSVLSMNLAKLIHPAMAGVTGIGAFVLLLLFGEMLPKSIAYSHSRQFALAAAPGVYLCTRITAPLLAIFDFIIVSPAVRLLTGGKVGQPIRQVNPKQLKILIDSSFQKGAITPDQSQIFSSVVELGFLKVRHVMRPRVDMVACDIRMPLADIKKTMTDNDLTVIPIYSRDIDNFIGVIYLKDLLLRPDEQPNRLLKRVPFVPEQKSIESLLEFFRESDIEVAVALDEFGGIAGIIDLQDIIEELLGTEETEGMEEPIQQLGPLKYRLSANLPVHEWSQSFGIDLEQSRFATVGGFVTALLRRVPKEGDTAKLGNIKFTVEKVKKHRIESIILELEPLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA1</accession>
    <name>A0A1U9NNA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">STSP2_02558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02558"/>
    <dbReference type="EnsemblBacteria" id="AQT69369">
        <property type="protein sequence ID" value="AQT69369"/>
        <property type="gene ID" value="STSP2_02558"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02558"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="299"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="463"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="621" mass="67684" checksum="F353123F3EC357A5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA6</accession>
    <name>A0A1U9NNA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rmlA</name>
        <name evidence="6" type="ORF">STSP2_02622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02622"/>
    <dbReference type="EnsemblBacteria" id="AQT69432">
        <property type="protein sequence ID" value="AQT69432"/>
        <property type="gene ID" value="STSP2_02622"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02622"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26537" checksum="1CB82D14B6287A25" modified="2017-06-07" version="1">MELKGVILAGGLGTRLHPLTKVTNKHLLPVGRKPMIYYPIEKLTAAGVTEILVVTGLEHMGDVVNLLGSGREFNCKFTYKVQDEAGGIAQALGLAENFAAGSSVAVILGDNIFQADLKPYADAFRKQSEGAKLLLKEVADPERFGVAQVDGDRIVGIEEKPAQPKSNLIVTGVYFYDHRVYEYIKTLKPSGRGEFEITDVNNIYIQKEQLKFEQLSGWWSDAGTFRSLNKVNELVAKEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNB5</accession>
    <name>A0A1U9NNB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Evolved beta-galactosidase subunit alpha</fullName>
            <ecNumber evidence="7">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ebgA</name>
        <name evidence="7" type="ORF">STSP2_02297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69110">
        <property type="protein sequence ID" value="AQT69110"/>
        <property type="gene ID" value="STSP2_02297"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02297"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="351"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="799" mass="89499" checksum="7A1B56D3CBA8DF61" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI7</accession>
    <name>A0A1U9NNI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F0F1-ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69395">
        <property type="protein sequence ID" value="AQT69395"/>
        <property type="gene ID" value="STSP2_02584"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02584"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9553" checksum="4C1BD27AC8C1E51B" modified="2017-06-07" version="1">MSENNDQRDQNDRWAAFAWMGIGIEFCAVVGFFMWLGSKLDKLQDTFPGFMIIGFFVGFALMLYIMIQRAGGLKGDGSKNRGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK9</accession>
    <name>A0A1U9NNK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69200">
        <property type="protein sequence ID" value="AQT69200"/>
        <property type="gene ID" value="STSP2_02387"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02387"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16861" checksum="0708856C87379DB8" modified="2017-06-07" version="1">MQSIDMYIYKINNRRDPMDGVDTKDTQPRAEQTLSISIPDSIPADYAEDFLERHAMLAVDGGLDDYDAAVQAEEEVLARIMHTYTARCYILWGEYHRDKWRSPIDRRVYHNNKPQTICVALTGTDREDALSKLDTDAEEFIEWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL7</accession>
    <name>A0A1U9NNL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69324">
        <property type="protein sequence ID" value="AQT69324"/>
        <property type="gene ID" value="STSP2_02513"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02513"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7582" checksum="5AD969EAF69A8B69" modified="2017-06-07" version="1">MVPTKTFSIDKTGIMEMPGKKIKQFSCVTEAEAKTCIMAWCADFNKKNYCGIHPNCRTFNETATSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN7</accession>
    <name>A0A1U9NNN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pknB</name>
        <name evidence="9" type="ORF">STSP2_02533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02533"/>
    <dbReference type="EnsemblBacteria" id="AQT69344">
        <property type="protein sequence ID" value="AQT69344"/>
        <property type="gene ID" value="STSP2_02533"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02533"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="411" mass="45588" checksum="28C1B5FA18E37BD1" modified="2017-06-07" version="1">MSETNFDTMFGRMAVDQGLVTEEDLKKIISELKAYREKNRAVSLRQLMVKRGLMTSDQAKRLKTYISESKSAAGQIPGYKVIGKLGAGAMAVVYKAKQLSLDRIVAIKVLPKRYSEKPNYIKRFYKEGKLAAKLNHNNIVQAIDVGEVGGLYYFVMEYVEGKTLYDDLSKGKIFDEGEALDIITQVARALEHAHAQGMIHRDVKPKNIMINSEGVVKLADMGLARETSDIKAAENERGKAFGTPYYIAPEQVRGELDIDGRADIYALGATLYHMVTGKVPFEAKTPSEVMKKHVTEPIVPPDHLNTSLSAGISEVIEVMMAKKKEERYTNVAELLVDLDAVKAGQPPVRAHDKFNLSDLSELEQEGEAVELEEGEERMYPASTVTGYKIAVTVLSLIIAILLVVILFMANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ5</accession>
    <name>A0A1U9NNQ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmuF</name>
        <name evidence="6" type="ORF">STSP2_02547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02547"/>
    <dbReference type="EnsemblBacteria" id="AQT69358">
        <property type="protein sequence ID" value="AQT69358"/>
        <property type="gene ID" value="STSP2_02547"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02547"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="315" mass="34387" checksum="032AA83B32D64E03" modified="2017-06-07" version="1">MKTYPLKFKPIFKERIWGGRKLKEAFGKELPEGAKIGESWELADLPEDKSVIVNGELAGKTLAEAIEMMGEAIVGSSSYEPPFPLLIKLLDAQDKLSVQVHPDAQTCKRRGKGDPKTECWYIIDKEPGAVIYKGLKEGVTKEQFAEAIEDGTVAELLVEVPVEVGECHFLPAGTAHAIGAGLLIAEIQTPSDTTYRVFDWNRVDDSGKGRELHVEDAMESITFDQDKSALTVNNVGRLVDSESFKVDKGHQAKGCEMILQSGPLKVLMMLSGTGEIRFGEDSQLPVEAGDTVLLPAAFEGVMIFGEESEYLVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT5</accession>
    <name>A0A1U9NNT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69612">
        <property type="protein sequence ID" value="AQT69612"/>
        <property type="gene ID" value="STSP2_02806"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02806"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54288" checksum="20894CC82196FB90" modified="2017-06-07" version="1">MHAFNDLKIEKSGDSLKITILICVALAIGLYLIATTVVIAKDGVGYIEDAKDLAATGSLGSRVYGPGYPYMISAWYRVLGFVVMPDSLVGWTTAAQSVTLLCKIAAIIPLYFVGKLVVGAGKSFWAVLILLILPAPAKYGSDVLREWPYILFLGLGLLLLMLGSRRQNIWAFAGAGICAGVGQMIRPEAVLLMLVVGGWAVAVFAGLNQGTGKGKTALMALAALAGFAIPSIFYVKVGGDLVAPQLRGLFAVCQMNRNLSHVSGHLQWVCAQTQTGVLESSWEVLEVIGQTVNYVFVVPLLLGAAKSFRRGKDLLRDEWFFIWCLMGIYFGMLVLLHVTHGYVSSRHCLPMIAFAVFFVPVGGIDIAKWLHSKLNFASVRMYALFLLAAAIAVCLPRLFRPINFDKQQFLQAAEWLDENCPEDALIGVLDARLGFYSSRQWEVFVRDVPSDADYVAIEAKDYDRMENPSARRVKTFSGDAEKEGVYVYKLRAEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP73</accession>
    <name>A0A1U9NP73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ_8</name>
        <name evidence="10" type="ORF">STSP2_02709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69518">
        <property type="protein sequence ID" value="AQT69518"/>
        <property type="gene ID" value="STSP2_02709"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02709"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012437187" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144053" checksum="07BB21B473EF4026" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC9</accession>
    <name>A0A1U9NPC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyl transferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02851"/>
    <dbReference type="EnsemblBacteria" id="AQT69657">
        <property type="protein sequence ID" value="AQT69657"/>
        <property type="gene ID" value="STSP2_02851"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02851"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="360" mass="40764" checksum="457EA9C4349B3A7A" modified="2017-06-07" version="1">MKISKLLKSVRLYGAARWGADRFLSAGEFLKRWVYRSVCRRELREREVLEERPAVLVVMCAGGIGNVIEATPLVQALRIRWPKCRLTILTPYEDMFGEWCIVDEVCSDRAELAGRRFDYTFVPFWGWHGFPENEVGDGFERGEVFVSRPALGKWFLRNERDYNVDLARRLGYRGPAPWSYVNVRKPAVADELAEPWLCVLPGGKTDDRWRWKRWPNYAELIGVVRKEWQGCRVCVVGTEDDEVDERVFEDEMVVDLRGKLSLAESAWVLKHSAGVVGNDCGPMHMADAVGARAVAIFGPTCVVKNGGRGKNVVITAGEGCQPCQYGEELTECEAGECMRELGAERVFAMVRDVLGRYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPI7</accession>
    <name>A0A1U9NPI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02902"/>
    <dbReference type="EnsemblBacteria" id="AQT69707">
        <property type="protein sequence ID" value="AQT69707"/>
        <property type="gene ID" value="STSP2_02902"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02902"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="73"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39654" checksum="4D8CACA8C1F814C5" modified="2017-06-07" version="1" precursor="true">MNNRKLAILGLLAVVIVVLAVAVDKVTHRGPQGSGTGGYLIEGMDPAKIARIEISGGESDVVLVRGNGGFVVETKGGYPAKTSEVNNLLTRSMDIALAEKITSDEKNYADLGVSEEEASTIVKFITEDGSLLTGIVIGEAVEGGEGKYVRLLNGEDVFVSLGSPWINKNAIGYVEQTLVSAEKDNIESVAVNAGDESYRIVRKDNNEIGLSTVPEGKEVKEDELDKVFNAATSIRFDDVLREVEGVSFNDKFVVRMEDSTVYRFDIGRKDDAVYGKVTAEFTDTEPVTMTKGVQVDEEELKQKEAKLVARDKAQAFAAKNEDWIFEIPSYKADNMTKPLSDLLEDKAVEEESGDEADQPAEAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP5</accession>
    <name>A0A1U9NPP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Colanic acid biosynthesis glycosyltransferase WcaL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69757">
        <property type="protein sequence ID" value="AQT69757"/>
        <property type="gene ID" value="STSP2_02954"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02954"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="41818" checksum="BF5898C59C7F9F67" modified="2017-06-07" version="1">MDNGSSKTSKSGKVPVRPAIFVDAYAIRDYATGLQHLLAGLAEKSHEAALVCPPDVNIDAVMGPTATAMCYPVFKLPFLCRQNRNMLVDRLGKFKPSVLHAFSSSRFKITRQVAHIMDLPYVLSVNRLALRPSANYMKDEHCTSVVASSRKISEAMCKKSPYAEEKLEQINIGTFVEDSTACFSGEHAVTSIILAQDLHKEQDFKALLNAIRHLVIDGYEFVLAILGKGKAERAIHRQIHSLELSQIITLVGEVEPIRPLFAGADVFIQPQPRREFNSRLLEAMSVGMAVATSRHIKDDMVIPDETAVVFDPYDELSVYSALQKILEDKDRARCMAQNGQDYLRKYHSVSRMADSLTDTYIGAQVKHKNLGAGEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR4</accession>
    <name>A0A1U9NPR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannosylfructose-phosphate synthase</fullName>
            <ecNumber evidence="2">2.4.1.246</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mfpsA</name>
        <name evidence="2" type="ORF">STSP2_02793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.246" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02793"/>
    <dbReference type="EnsemblBacteria" id="AQT69600">
        <property type="protein sequence ID" value="AQT69600"/>
        <property type="gene ID" value="STSP2_02793"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02793"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103011">
        <property type="term" value="F:mannosylfructose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="793" mass="90273" checksum="773D77F08F01FB7A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW3</accession>
    <name>A0A1U9NPW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69650">
        <property type="protein sequence ID" value="AQT69650"/>
        <property type="gene ID" value="STSP2_02844"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02844"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346510" evidence="1">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="40280" checksum="7ED98F11C302017C" modified="2017-06-07" version="1" precursor="true">MKTKFVTFAVLALAILAMSGCSSQTGPRHSTSQPMTTPAGMIEYLDCVPALQNAQVWQNSYSDGLILNTEHYKVYTTLLDPLMLRQVPAFLESAHREYQKQTPATLETHSPFVIYLFKDREQWENFTKEFTGKQSDLYLKIQRGAYYLNGACVAYNIGRSRTFSVLGHEGWHQFNSRHFTYRLPSWLDEGLATLFEESSYINNRFVFRPNQNLGRLGSLRKTLIDENAIPLKTLLALNPGEVVHYQDSEDVMAFYAQAYALVRFLREDNYGQRYAQFQNLLSDAIEGTWPLSQDEQKIASNRNIPFTTSWNRYVSPKLFNQYIEGEIGLLQKDYSRFCRKIVYNIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX8</accession>
    <name>A0A1U9NPX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.127</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kduD</name>
        <name evidence="1" type="ORF">STSP2_03194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.127" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03194"/>
    <dbReference type="EnsemblBacteria" id="AQT69993">
        <property type="protein sequence ID" value="AQT69993"/>
        <property type="gene ID" value="STSP2_03194"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03194"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047001">
        <property type="term" value="F:2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008678">
        <property type="term" value="F:2-deoxy-D-gluconate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011286">
        <property type="entry name" value="2-deoxy-D-gluc_3_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01832">
        <property type="entry name" value="kduD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26652" checksum="3899B3ED212E94ED" modified="2017-06-07" version="1">MILDKFKLDGKTAIVTGAARGLGQGMALGLAEAGADIAAVDILDMDDTRAKVEALGRKCVTIPADLSDKACVDTIVTKTVDELGGIDILVNNAGIIRRAPLAEFTEADWDDVMNINIRTLFFLSQAVAKIFTKQGRGGKIINTASMLSFQGGIRVPSYTASKSAVMGLTKLLANELADQNINVNAIAPGYMATDNTAPLRADPQRSKEILGRIPAGRWGTPEDLAGAAVFLASPAADYIQGYTLAVDGGWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY2</accession>
    <name>A0A1U9NPY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC</name>
        <name evidence="2" type="ORF">STSP2_03192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.92" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03192"/>
    <dbReference type="EnsemblBacteria" id="AQT69991">
        <property type="protein sequence ID" value="AQT69991"/>
        <property type="gene ID" value="STSP2_03192"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03192"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39787" checksum="1C9982E80602026A" modified="2017-06-07" version="1">MSVLNIKPAQNCKYDILSLGEIMLRFDPGDTRIHTTRSFRVWEGGGEYNVARGLRRCFGKRAAVVTAIPDNPVGRLLEDLILQGGVNTEYIRWQPFDGIGRDTRVGLNFVEKGYGVRAALSCSDRANSAASQIQPGQIDWNSIFANDGVRWFHTGGIFAGLAENTAPVIIEAARAAQANGTIVSYDLNYRASLWKSIGGQQKAREVNRAIAPYVDVMIGNEEDFSASLGFEVPGLDANLSKLDPSNFKKMIENAVAEYPNFKVVATTLRNATTATRNDWGAVIYADKQFHEATMRPQLEIYDRVGGGDSFASGLIYGLLEDKSPAQAVNYGAAHGALAMTTPGDTTMATLPEVERVINGASARVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY6</accession>
    <name>A0A1U9NPY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69969">
        <property type="protein sequence ID" value="AQT69969"/>
        <property type="gene ID" value="STSP2_03169"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03169"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="530" mass="58349" checksum="E6BC805D82271D8A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ70</accession>
    <name>A0A1U9NQ70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69965">
        <property type="protein sequence ID" value="AQT69965"/>
        <property type="gene ID" value="STSP2_03165"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03165"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28186" checksum="0DDDE37E3D0B32CB" modified="2017-06-07" version="1">MILTRPTITYMLDGTTLTAAVTSSYDVQMYVKSDADADWTDAGLVTGPSDADELVIADLDASRVYAALGVARSDSLAAISAPTAAKIFRPVATETEVTATGAFGKAAAALRDMIAASSTFQNDIGAVGTDEEKQAQAKQYIHIALYDPDTEFERPFVLISPTDSDRSELYAEAAYAGSGQLKVEFERSIPTAYQAAEQTANAELDFHNFVDGVIDDCQKLSSEPGYLLTREWNRIMQPARYAHDIEAYLTAFHVLWGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ74</accession>
    <name>A0A1U9NQ74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70059">
        <property type="protein sequence ID" value="AQT70059"/>
        <property type="gene ID" value="STSP2_03261"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03261"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="32160" checksum="178450F0E527DB08" modified="2017-06-07" version="1">MGKKNDFKHGDKEMKNVILIIAVVLIVLTAIVGIPKMRSYWSVGRENLVNTIDNALGEFRVKRAESSEGIQGLEKTVRKLKEGQIRCEVQAERLVTKLNDLTQKRDKAVHSLKRLRELISEGEPAVLGGREYSVTELQEMAEDLMRTHESIKAQMDSITDARDLLEKNAYSLKEKAGHAKRTVSSMHAQLEEIDAKIVSLDTMRKAAMIAGGKDETLATNFDSVKKQLDQLYVEVEIGLRMEQADWKASSTAEANIDEIFIETQDADETLERIDDVLGMNTEVTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ94</accession>
    <name>A0A1U9NQ94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70079">
        <property type="protein sequence ID" value="AQT70079"/>
        <property type="gene ID" value="STSP2_03281"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03281"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="110" mass="12295" checksum="60B7BF32231241ED" modified="2017-06-07" version="1">MEKYKTPEMFACLGAAVFLFIGVGRMPYDYYTFLRLVVCGCAGFLAYRGFAMKKEPAAWVLIAIAVVFNPFAPIHLSKEIWQVVDLITAVGFIAFVPYLGKEPDQESEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA4</accession>
    <name>A0A1U9NQA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ORF">STSP2_03317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03317"/>
    <dbReference type="EnsemblBacteria" id="AQT70113">
        <property type="protein sequence ID" value="AQT70113"/>
        <property type="gene ID" value="STSP2_03317"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03317"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37624" checksum="02424391AFCB7E85" modified="2017-06-07" version="1">MILDTILGWFSTDMGIDLGTCNTLVCVRHEGVVLNEPSVVAVRKGTNIVLNEGEAVGLVARDMLGKTPGSITAVRPLKDGVISDFEITERMLSYFIRKVHGRRGFMRPRVVISVPSGITAVERRAVIDSAERAGAGKVYLLDEPMAAGIGAGLPITEPTGSMIVDIGGGTTEVAIMSLGDISTCESVRVGGDNFDEAIINHLKRTYNLLIGEPRAEQVKIQIGSAAPLEQELTMEIAGRDTISGLPRKIVITSEEIREALREPIAGIIEAVMQTLEKAEPELAADLIENGVHLCGGGSLLRGMDKVISNATGLKVIAVEDPLSCVARGTSVFLENLHLWKDTLDQEGYAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB8</accession>
    <name>A0A1U9NQB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectate lyase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03007"/>
    <dbReference type="EnsemblBacteria" id="AQT69810">
        <property type="protein sequence ID" value="AQT69810"/>
        <property type="gene ID" value="STSP2_03007"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03007"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346512" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="251"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1463" mass="154464" checksum="3949AB0844553E01" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC6</accession>
    <name>A0A1U9NQC6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rho</name>
        <name evidence="12" type="ORF">STSP2_02912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02912"/>
    <dbReference type="EnsemblBacteria" id="AQT69716">
        <property type="protein sequence ID" value="AQT69716"/>
        <property type="gene ID" value="STSP2_02912"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02912"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="320"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="332"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="574" mass="64925" checksum="14D3A5FB541278D9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD6</accession>
    <name>A0A1U9NQD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69938">
        <property type="protein sequence ID" value="AQT69938"/>
        <property type="gene ID" value="STSP2_03138"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03138"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11891" checksum="950B5D9D4176B838" modified="2017-06-07" version="1">MVGGELGYFVKRCGVDGYQIPVFFVVRGEELAARIFWHPAAGDYALTTKEDMSMTRETLARCLEIMNTQSLRIMRRKSERLQKNYLLKRQSEKAKRRDKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH5</accession>
    <name>A0A1U9NQH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69978">
        <property type="protein sequence ID" value="AQT69978"/>
        <property type="gene ID" value="STSP2_03178"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03178"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6659" checksum="A15C79BE568BF7F0" modified="2017-06-07" version="1">MDKRSSVSAVSAPRRTDERTARDLDFARERLLKNIQERLREKDTLYLIALHDWLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI0</accession>
    <name>A0A1U9NQI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70037">
        <property type="protein sequence ID" value="AQT70037"/>
        <property type="gene ID" value="STSP2_03239"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03239"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="493" mass="54799" checksum="3C3DF560F7B94934" modified="2017-06-07" version="1">MISDDQRIALCKLIMGLMDGSITDHGLSVLNQQLAQSPEALEFYREFMKNTALLKNGIDLSQSSLSDPISSDFWAELSKYEMTAPAVVVSEQEEGRNIIQKVEYPQREKHKLSKFQIVTLIISSAALLFVVFILNFVRPKEGSIKVATLVDQVDAEWTDEGVRWTNGVGFWTGDSPYLLTKGFARILSNNGADVIIESPAKFEMRDTDEIFLYYGKVACSVPPKAYGFKIQSADFEITDLGTEFGVTVRQNQSSEVSVFDGKVEMASLYDKHYDNVLTAGQAKQVSYGSGTVSDIPCDRYAYKQTWKDVLTSVEVKGSIDFLRASPKSLEQDAFESDSKMFLIEERKSVPLQNEITGLISSGQYTSQDLTLDTEAIPGQVDKPVDSFLLHIDRVGGTSFEQNLVLNGTIAFRCPIVGVLVDTDKIIESDSLFGNPNVDYSDDINRGITGESSTWREIDESTLDVLTLSEDRKTLMVKMVAGNFDQIRILVESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ3</accession>
    <name>A0A1U9NQQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_5</name>
        <name evidence="5" type="ORF">STSP2_03468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03468"/>
    <dbReference type="EnsemblBacteria" id="AQT70262">
        <property type="protein sequence ID" value="AQT70262"/>
        <property type="gene ID" value="STSP2_03468"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03468"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="235" mass="26303" checksum="806104AE633DA7ED" modified="2017-06-07" version="1">MSTPRTIDNSVINLQNIRKIYEMGDQQVRALDGVDVAFEPGSFWAIMGPSGSGKSTMLNILGCLDRPTSGSYHLHQEDVSRMDDDHLSEIRLKHLGFIFQSFNLIPQLSVQRNIELPLFYLGWDEKESRERSVELAHKVGLEGRLNHRPAELSGGQRQRVAIARALANDPKILLADEPTGNLDSVTGAQILELLDELYQNGKTVIMVTHESEIAAHARKILHMRDGKVQKIEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW0</accession>
    <name>A0A1U9NQW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03372"/>
    <dbReference type="EnsemblBacteria" id="AQT70167">
        <property type="protein sequence ID" value="AQT70167"/>
        <property type="gene ID" value="STSP2_03372"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03372"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12230" checksum="85372F58C9932829" modified="2017-06-07" version="1">MANQAKDFYGEWKHKTKKMQEMAPDTVKGFAGMFEKIMGEGALSVREKELVALGIGLSEQCQPCIYLHVQKCLAAGATKEQIMEAASVSVVMSGGPAFTHLPEVIEALEALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR34</accession>
    <name>A0A1U9NR34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal bacterial protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03453"/>
    <dbReference type="EnsemblBacteria" id="AQT70247">
        <property type="protein sequence ID" value="AQT70247"/>
        <property type="gene ID" value="STSP2_03453"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03453"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="26192" checksum="AC144EF225541BF6" modified="2017-06-07" version="1">MTQKHEPGITLAVDTSGRAGSVAVGVGKDLWASRPFSGALRHNAELFPTIQDLLREFNENPARIAYIGITSGPGSFTGIRIAVTLAKMIAMANNAAIVTTRSSDALIRNLQNEGGYEYAATIIDAKRGMFFTAVFQNIEGKWVKIVDDRLIQPQEFVELAEGYSGKICLLGEGLEYYSDRFAGEKIEIAPKDLWSVRADNVYRIAQDLIEASDFVEPEKLKPFYLRRADAVKKSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR79</accession>
    <name>A0A1U9NR79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sucC</name>
        <name evidence="9" type="ORF">STSP2_03493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03493"/>
    <dbReference type="EnsemblBacteria" id="AQT70287">
        <property type="protein sequence ID" value="AQT70287"/>
        <property type="gene ID" value="STSP2_03493"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03493"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate_bind" evidence="8">
        <location>
            <begin position="261"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="414" mass="45268" checksum="57198831A923D82D" modified="2017-06-07" version="1">MAAQITELTFLEHLAGRFKLPVPEYVTAESGQTKVRELLKKWGGKAIVKPDVLAGKRGKAGVLRQVNDYVDAQRELKIIQGTEVQGQLPRTSYMVEFIPSEMEVYSAITYDSRYLGPSITISLDGGMDVEEIGEEKKVTLPLDIYKGLGAYQASEVLEQLGCPRKVISPLSRSLVDLWDMFISTGMRMCEVNPWRITPAGKPYACDFKAIFDESNFKFKNIGFDLPEYPANATLFEEEMAAWNASSHRGQAHVSELGGKTILPLLFGGGASTIITETLMQNGGDPIFLSDFGGNPPYERMYGTAKLCFEHNLGKAGMLLILGGKANNTLIDVTFKAIADALQNYVDEHGPINIPVVVGRGGPRLLQGLLTLKDTLDTLGMPYVMFGPDTPVTQVAEYAAKLANNWGEVMVGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR87</accession>
    <name>A0A1U9NR87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligosaccharide amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03344"/>
    <dbReference type="EnsemblBacteria" id="AQT70140">
        <property type="protein sequence ID" value="AQT70140"/>
        <property type="gene ID" value="STSP2_03344"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03344"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="759" mass="85895" checksum="3E0AEA9877E5B6AD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC0</accession>
    <name>A0A1U9NRC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxyphenylacetate decarboxylase activating enzyme</fullName>
            <ecNumber evidence="11">1.97.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hpdA</name>
        <name evidence="11" type="ORF">STSP2_03490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03490"/>
    <dbReference type="EnsemblBacteria" id="AQT70284">
        <property type="protein sequence ID" value="AQT70284"/>
        <property type="gene ID" value="STSP2_03490"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03490"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31876" checksum="CA7EB574E2EE45CC" modified="2017-06-07" version="1">MGVVFDIKKYAIHDGPGIRTTVFLKGCPLRCVWCHNPESWRLRPEVGVRSGRCVRCGACVQACEKGAAEPGRGVDGEVCSVCGGCVTACASGAREVIGEEKTVEQVVREVEKDIIFYDESGGGATFSGGEPLMQAEFLAECLEQLRRQDIHTAVDTTCYADAEVLRAISGDVDLFLCDIKHMDSGKHRSSTGVGNELILANIEMLAGIGKQMYVRVPVVPGFNADEENVARTAEFVSGLKTVRRVDVLPYNLGGVEKAGRLGHSGGIERFEMPQDEDMSKILDVFAAFGLDARVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRD1</accession>
    <name>A0A1U9NRD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maritimacin</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70294">
        <property type="protein sequence ID" value="AQT70294"/>
        <property type="gene ID" value="STSP2_03500"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03500"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28416" checksum="E0A7792411D09DDA" modified="2017-06-07" version="1">MSEKFLHRDEAPFSPAVWQMIDETVVGAAKAQMCGRKLLHTEGPFGLGLKSISTGDNEVTSQEGISAYAGCCTPLVMISSSFKVPARDIAAFESNGAPLSMAQAAQAAIKCARMEDTVVFNGSKELGTQGLLTAKGGGSHKIGNWQEVGKAADDVISGATLLDKQGFVGPYVLALSPTLFENLYRRYPDGDMTELEHIKQIATGGIIKANSLEKGGVMMQTGKQFASIVLGQDLMTGFIGPEGTSYEFSISETAALKLNRPEAVCVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRK7</accession>
    <name>A0A1U9NRK7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groL_3</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">STSP2_03456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03456"/>
    <dbReference type="EnsemblBacteria" id="AQT70250">
        <property type="protein sequence ID" value="AQT70250"/>
        <property type="gene ID" value="STSP2_03456"/>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="538" mass="57094" checksum="50A69EC76E52D8B6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRL1</accession>
    <name>A0A1U9NRL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nnr_2</name>
        <name evidence="6" type="synonym">nnrD</name>
        <name evidence="7" type="ORF">STSP2_03371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03371"/>
    <dbReference type="EnsemblBacteria" id="AQT70166">
        <property type="protein sequence ID" value="AQT70166"/>
        <property type="gene ID" value="STSP2_03371"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03371"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="29560" checksum="225A3788D0A4582D" modified="2017-06-07" version="1">MQEIKTLPTLKPRAQDSHKGTFGRVLVAGGSWGMSGAPAMTALSALRSGAGLVKVACPDSVLPTIASISPCYTTLSLADDDGAMAGEAVGPLLAETEQNDVIAFGPGVTTARGVRDCLTALLREKDLKIVLDADGLNCLAKIHSRHEKVSASAVLTPHPGEMKRLWKALVREDQPADRIEQAAKLASSTGTVVTLKGAGTVVSDGERYYVNETGNPGMSTGGTGDVLTGIIAALIGQGLDNFDASVLGVHLHGLAGDIAAERTGQISLIATDVIDALPQAFRKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG37</accession>
    <name>A0A1U9NG37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliE</name>
        <name evidence="5" type="ORF">STSP2_00031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00031"/>
    <dbReference type="EnsemblBacteria" id="AQT66893">
        <property type="protein sequence ID" value="AQT66893"/>
        <property type="gene ID" value="STSP2_00031"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00031"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11403" checksum="2BD50C477AB6D728" modified="2017-06-07" version="1">MINFNPNISQIQQTNRINQPNGPTKTGEGSDKFQNTVKQYTDKVNELQNNADDNVKDLLAGKTEDVNSVVADVAKADMSFKALVGVRNKIIEAYKETMRMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGD6</accession>
    <name>A0A1U9NGD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00013"/>
    <dbReference type="EnsemblBacteria" id="AQT66875">
        <property type="protein sequence ID" value="AQT66875"/>
        <property type="gene ID" value="STSP2_00013"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00013"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="161"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="46310" checksum="0FEE9E90D05CA0DF" modified="2017-06-07" version="1" precursor="true">MGRAVILFMMAVGVCVGVSGGAEYRTFNDSIESIAEGKGLPTPPKPVEPEKLEIVSAKYGAEDKWLDVTDELRSRVDSNRLSIYVSNNIAGDPFFGHPKHLVVTYILDGVEKEVRVREGKQLQIPRPSDPMDALSVIETPRDLTALAKVCPAEVGFYGINLNTGATLGYRSEQPACLASIVKLFVLLEIMRQQDAGGLKLSESVEIDRGGEKESCTITEAIDKMIGVSDNEATTALARRVGYENVDALAKKLSIEGLSMTVWPRPGGLEEQLDKRVFGAKVLPKDKFLPQHGTARSVVEFFKLLHEGKLFNKAVSEKVLASLMRNPKRFAPRGTPAGCESVGKGGSIIWKRPPRPQYNMLGWGLYVFDEKRAAAFCVWFEWFPESMPENKRWAWANGFSDCVVDLLLNEEKQASLKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGF6</accession>
    <name>A0A1U9NGF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67013">
        <property type="protein sequence ID" value="AQT67013"/>
        <property type="gene ID" value="STSP2_00151"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00151"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22562" checksum="90147939F3F58BDE" modified="2017-06-07" version="1">MSSESGKTNQSARRSQANFTIGGIVLVIFVMIAGILQLCGCEPKDNRQTYEKGCIELLGGIVDEKVKYHKLQIGNAAEPLYAMADIPEIYIEKLNGELISLKEVTAEYLQRNADTTIPANELNGWPPNTTNFKFTERASFKVSEDGRILGLTCGALWTKDGFLEPSVLWNSGKTKRYVFPLNHKEAIELFGQPDKVKKGFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS6</accession>
    <name>A0A1U9NGS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66967">
        <property type="protein sequence ID" value="AQT66967"/>
        <property type="gene ID" value="STSP2_00105"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00105"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15991" checksum="2DE03F512AC6FBD7" modified="2017-06-07" version="1">MSKVTVDLNKIEASDGRGSVFAGRIDMLRARAEVLSGKDRAIMEMYLDHGETFSKMARVAGVNEATIARRINRLVARLINSEYLTCLRNRSSLEGFELLVARDYFLEGLSQRKIARKRGTSVYRVRKALMNIQRLVKPGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGV3</accession>
    <name>A0A1U9NGV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiesterase, family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67163">
        <property type="protein sequence ID" value="AQT67163"/>
        <property type="gene ID" value="STSP2_00306"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00306"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="325" mass="36718" checksum="75403BB76F3AD504" modified="2017-06-07" version="1" precursor="true">MHYKNITRRTFLRTTAAGVLASALPGCTSRTLTRPNTPAVSFGICADVHKDLVPDADQHLAEFITEANKRNVDFVIQLGDFCRPYDKNKKFLDIYHSFQGPAYHVLGNHDTDGGFTREQTLAFWNSPAKYYSFDCNGVHFVVLDGNDIKPNRAPGYPRYIGPEQQDWLARDLAATNLPTITFSHQSLNASDDHIENAAELRAILELANKPKRKILASFNGHEHADYVETINGIHYVNINSTSYQWLGGSYQAKRFSPEIEKEYPYISYTAPYRESIYAFVTIHPDHSIRIEGKTTEFIPPTPADLNHPNANTKRSTPKISNRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH01</accession>
    <name>A0A1U9NH01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00186"/>
    <dbReference type="EnsemblBacteria" id="AQT67047">
        <property type="protein sequence ID" value="AQT67047"/>
        <property type="gene ID" value="STSP2_00186"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00186"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="466" mass="53292" checksum="6074209E2293C88D" modified="2017-06-07" version="1">MDRRDFLKLSGAAAGSLMLGACQSEYQKVRAAEVDLPMPTAAQLAWQQAEIGVLVCYELHTFNEDRYVQSRERRRPIKDVNQFNPERLDTDQWVRAVKNMDARFAILTASHESGFRLWQSDVNPYCLKAVEWGRGKRDIVGEFVASCRKYGVKPGIYLGTRWNSHLGVWDFKVTDRSPLTQQEYNELIEKETEEICSRYGDLFELWYDGGAYGPDKGGPDVLSIFEKYQKDCIFYHNHQRADVRWGGSETGTVGYPCWAMMPYDGWSKHNTELAKDRFWLLKHGDADGKVWCPAMSDAPLRNHEWFWEPNDEHKLYSLDALMNMYYKSVGRNSTLILGLTPDTRGLVPDADVERCKELGDEVQRRFGEEIASTSGYGKQVVLELEPGTVINHVVIQEDIARGERIRQYSVEAKQAGQWKQVRKGRSVGHKRIEKFAPVEADAVRLTVLDSVADPLVKRLAVYNCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH85</accession>
    <name>A0A1U9NH85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dmdA_1</name>
        <name evidence="6" type="synonym">leuC</name>
        <name evidence="8" type="ORF">STSP2_00436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00436"/>
    <dbReference type="EnsemblBacteria" id="AQT67293">
        <property type="protein sequence ID" value="AQT67293"/>
        <property type="gene ID" value="STSP2_00436"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00436"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="420" mass="44924" checksum="1CF17A89E087889A" modified="2017-06-07" version="1">MGMTITEKIFAKAAGKESVKAGDIVNAKIDVIMCHDVTTPPAISMLKEKGIDTVFDPDKIVVTPDHFQPAKDIKSAELHKRLDTWCKEKGITNYYKLGKAGVCHALLPEQGHIRPGEVIVGGDSHTCTYGAFGAFSSGIGSTDLAAAIATGELWFKVPASLKFILNGKLSEGVYSKDVILEVIRQIGTDGALYMAMEFVGDALKDMTMEARMTITNMAIEAGGKSGIIGVDEVTKKYLTETLKDTSEYDVFESDGDAEYVKTIKIDCGALEPMVAKPHLPSNGAPISECAGLEMDQAYIGSCTNGRIEDLRIAAEILKGKEVAIRTIVVPATPEIWKQCIDEGLAEIFYDAGCVVSAPTCGACLGGFMGILAEGERCVSTTNRNFVGRMGHPKSEVYLASPATAAASAIEGKLTDPRKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC4</accession>
    <name>A0A1U9NHC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthesis protein FliR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00044"/>
    <dbReference type="EnsemblBacteria" id="AQT66906">
        <property type="protein sequence ID" value="AQT66906"/>
        <property type="gene ID" value="STSP2_00044"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00044"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27390" checksum="D1C0DDBF1EE0ECA4" modified="2017-06-07" version="1">MTFTSATLLGFVLVLTRLSVFFATAPIFSWITIPVRIKVGLALFCSFFFSLSLSPPEIGAGVGLLEVVLMFMMEGIYGLSLGLILTMLYSAVKVCGRILEMQMAMSMAQEMDPFRGERQQPLSILFEIIFLLLLLSANVHHMFLELLHTSFEAFGPGEFPGVAGMTQAVIEAGSMMLVFGLRLAIPALVVFTILMVVLAVMARIAPEMNILFLSLPFKVGLGLLIAAYLVPYIQTYVSEYANAVGRMLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH6</accession>
    <name>A0A1U9NHH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67373">
        <property type="protein sequence ID" value="AQT67373"/>
        <property type="gene ID" value="STSP2_00517"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00517"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527447" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18128" checksum="7394F9619CEB10CC" modified="2017-06-07" version="1" precursor="true">MKFKTLTLITFALFATTTASANLITGDGIPLIQYDSFSGLVLVDDDGANVTRIALDFHETTNEDTGLKSSKPQVDSVNSYSVRRVILDWPSLDFLSVLAEMLGFNEPLEAWAHISPDLVPEDFAGARYWVEGSTEEYQTDIHVVPEPATLALLTIGTLTLRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHI8</accession>
    <name>A0A1U9NHI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">iolG_1</name>
        <name evidence="8" type="ORF">STSP2_00114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66976">
        <property type="protein sequence ID" value="AQT66976"/>
        <property type="gene ID" value="STSP2_00114"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00114"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="55"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="461" mass="51839" checksum="D5CA048D8C14892F" modified="2017-06-07" version="1">MLASRMFHDVKMEGYDMAAANIGRRDFLKGAAAATGLVILPSGVLAGENAPSNKLNIALIGCDGRARAHYGVLKGENVVALCDVDEEHIAHAAKTFPNAKHYVDWRKCLEQKDLDAVVCCTLDHTHAFIANWAMNRGLHVYCEKPLANTVEEARVVRDTYLKNRGKIATQVGTQRHQYPNFERVRELIRDGAIGELQDARAWGNRQLRKDGYLPGKGKPPKNLHYDLWLGPAQHHPYNPGYFDGRPGANCLNWNMYWDFGTGQVGDMGSHTMDIIWNAIDAGRPETAEAKGEKYDPEVTPVELQMTWRHPANDWRGPINVMWYQGGMMPNSPRKYVNLNRIGHGAMFKGTKGFIVCDFNSRLVIPWGPDADMTYFEPRKEEEVAEPMGHFQREWIDACKGDLKTSCDFDYAGLMIEQMMLGLVAYRAGEKIEYNGETGRTNNAKANSLLAKEYRKGWTLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL9</accession>
    <name>A0A1U9NHL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67244">
        <property type="protein sequence ID" value="AQT67244"/>
        <property type="gene ID" value="STSP2_00387"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00387"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="17337" checksum="376060C694F584FD" modified="2017-06-07" version="1">MTKGLNNLVDNGLLELAMYYRPGDKYAFCFYVQTSGRVPVKNLLEDLNRTGKLHESESKGWGGKNVVARLFRTIGNLAQGKVVSRSFYKKLDKTLWQFTCYDIRFLAFHDGNAIVLVSGFEKKTQETPEKEKKKARKRHKEYLKRKRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT2</accession>
    <name>A0A1U9NHT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">der_1</name>
        <name evidence="7" type="synonym">der</name>
        <name evidence="11" type="ORF">STSP2_00447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00447"/>
    <dbReference type="EnsemblBacteria" id="AQT67304">
        <property type="protein sequence ID" value="AQT67304"/>
        <property type="gene ID" value="STSP2_00447"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00447"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="177"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48268" checksum="0D6FC4704643B422" modified="2017-06-07" version="1">MALPVVTIVGRPNVGKSSLLNSLAGEMISIVESTAGVTRDRVSTLVELNGRYVELVDTGGYGIVDEGELTRHVEEQINNAVAMADVVLFVVDIRDGIMPLDQDIAQMLRKHDLDVILVANKADSPKQLGSAGEFQRLGFGEAIPISATNFVNRAELLEKVSDNLSHMPVELPKRERVRIAVVGKRNAGKSTFINSVVGETRVIASDIPGTTRDAVDVIFDYKGEKFCLIDTAGVRKKRKMSNSIEYYSYTRAARSIKRADVVLFMVDSTLPLSQPDKKLAAMINEEYKACILVINKWDLANDAADPDDYLDYVDKMLPGMRHCPIAFTTATTGENLENVLHLTTEVFQQASTEVPTPKLNKAIETISEARIGGSKRGIPKIYYATQVAVRPVSLLLFVNDPGLFNNTFKRFAINKLREMLDLEEVPIRLMFRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW8</accession>
    <name>A0A1U9NHW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">STSP2_00669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00669"/>
    <dbReference type="EnsemblBacteria" id="AQT67521">
        <property type="protein sequence ID" value="AQT67521"/>
        <property type="gene ID" value="STSP2_00669"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00669"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="467"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="589" mass="65642" checksum="FBAF97B7EF4F2720" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW9</accession>
    <name>A0A1U9NHW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67523">
        <property type="protein sequence ID" value="AQT67523"/>
        <property type="gene ID" value="STSP2_00671"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00671"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7580" checksum="6D9D418A3FE21E14" modified="2017-06-07" version="1">MVISVVEATDGARVMTVLWVLQPVAWVVDLKGSQRLTGLFVVVGGRLGVNVCKRPALVSTGLEDVFAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY5</accession>
    <name>A0A1U9NHY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose--fructose oxidoreductase</fullName>
            <ecNumber evidence="2">1.1.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gfo_1</name>
        <name evidence="2" type="ORF">STSP2_00521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.99.28" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67377">
        <property type="protein sequence ID" value="AQT67377"/>
        <property type="gene ID" value="STSP2_00521"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00521"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047061">
        <property type="term" value="F:glucose-fructose oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="38827" checksum="FF5EC01456C648AD" modified="2017-06-07" version="1">MAEKLKTAIMGLSPVGVKLLEAADRTSLFELRAVADSDGEQAQKIAAIYDCQPHNDYRQLVIQPDLQVLLVAEPMHLCREHLRVAIKNNCNILKLLPPALDFEQAADMIRTAEKQKVKFDVASRIRVAPGFRKVKEYIRAQGREKFHLITAVCHLPAQQLEPNERWLADPQLAGGGVILQKCYELLERVVDIFDIPQQIYTLLTSHAPDRKQRLSTTEDTALITMKFSDTLLANVTASRVLGPPALMLRIHSKENYIKATPDSMTLFDNQGEILEQYNYIQQPDNSLETMLTEFAHSITNPPKPPTEPTYHPIIETMSLIESAYVSARTAMPEPTQRILKLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHZ1</accession>
    <name>A0A1U9NHZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase 3</fullName>
            <ecNumber evidence="3">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoB</name>
        <name evidence="3" type="ORF">STSP2_00582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00582"/>
    <dbReference type="EnsemblBacteria" id="AQT67435">
        <property type="protein sequence ID" value="AQT67435"/>
        <property type="gene ID" value="STSP2_00582"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00582"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012662671" evidence="2">
        <location>
            <begin position="29"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="50160" checksum="247D68C87C24FBE3" modified="2017-06-07" version="1" precursor="true">MYLRGVKKLSVVFACVGVVFFAAGVCPAEEAGRAASPKNIIIMIADGCGFNHVDTASYYQYGHKGRQVYEQFPFKIAMSTYAAGQTYEPEQAWKYFNYVEGGGYARCTDSAAAATAMSTGTKTYKGAIGVDLDRFDLANILEAAEKSGRATGVVTSVQFAHATPAGFSAHNVARGNYAEIAREMIYESGLEVIMGCGHPLYDENAKSVEEPKDFKFVGGADAWADISDGEVEGADADGDGKRDSWTFVDTGDGFEKIGEGDTPKRVLGIPRVRSTLQYNRAGGREQEEPYAVERNKGVPALATMVRAAINVLDEDEDGLCMMIEGGAVDWAGHGNNLPRMIEEQIEFNRAVETVVDWVEENSNWQETMLVVTADHETGYLTGPGSGANEDGPVWKEIVNNGKGKMPGGEWHSGGHTNSLVPFYVKGRAGREFVMRADGFDPVRGHYIDNTDIADYVFELLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI53</accession>
    <name>A0A1U9NI53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67601">
        <property type="protein sequence ID" value="AQT67601"/>
        <property type="gene ID" value="STSP2_00749"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00749"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15301" checksum="72B8EEDCF66496F8" modified="2017-06-07" version="1">MPTLFKPICVTIICSFVGALISYAIIVFGDLYYGMASREVFIGIGGVVLSIAGIHAYSLIGRHKPKPLMLALVPIITFVCVMISSLAYGFLCYLVASITPINDIFWGLMVYIAFYAPSNVFVLYYLLIHRHTMPLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI79</accession>
    <name>A0A1U9NI79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA_2</name>
        <name evidence="4" type="ORF">STSP2_00634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67487">
        <property type="protein sequence ID" value="AQT67487"/>
        <property type="gene ID" value="STSP2_00634"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00634"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7208" checksum="7AC09A916BF4AD5E" modified="2017-06-07" version="1">MSTGKVKWFDDSKGFGFITPDDGGSDLFVHHSEIQAQGYASLQDDQAVEFEVGQGKKGPCATNVKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI81</accession>
    <name>A0A1U9NI81_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">top6A</name>
        <name evidence="7" type="ORF">STSP2_00673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00673"/>
    <dbReference type="EnsemblBacteria" id="AQT67525">
        <property type="protein sequence ID" value="AQT67525"/>
        <property type="gene ID" value="STSP2_00673"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00673"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="6">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="364" mass="41222" checksum="72AF9D30920CC60D" modified="2017-06-07" version="1">MAKRKNIPIEERIIENARGVHGKIVKSQKPTMSTPVRSLSNVKYDTKKGFFQIMGKSKLRTLTVSTCKAFAQTLKMMALSKELIDTDDIATKREAYYISKNWGKAGFSDQPESDTIMDDVEAMFTVNREQLKFVPEEKGGDIAGNLIVMDKDSKGRKLKIDCTKFGSGAYSIPSSVEELKFKSDAKFILAIETAGMFQRLVKYDYWAKQNCILVSMGGVPTRACRRFIRRLSDELKIPVYAFVDGDPYGYFNIYRTLKVGSGNAAHINEFFCVPKTRFLGVTPQDIKDYGLPTHPLKEVDIKRAKDALKNDPFVKHHKKWQAAINQMLKMGVRVEQQAFAKHGLDFVVNEYLPAKLKKTSSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI93</accession>
    <name>A0A1U9NI93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium transport protein MgtC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00463"/>
    <dbReference type="EnsemblBacteria" id="AQT67320">
        <property type="protein sequence ID" value="AQT67320"/>
        <property type="gene ID" value="STSP2_00463"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00463"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16554" checksum="64B4E65E9F243D14" modified="2017-06-07" version="1">MDMNFDMQELIGLLMAFTLGGLIGIEREINGKPAGLRTNIIICVGAAAFTVLGRHFAGEATEEVPEAFARLAAGIITGVGFLGGGVLIREGSTVHGLTTAASIWLVTSIGIACGIGSYALAITVTLLALVVLLGLSPVAHRIRDVKDEEHRRDSRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB5</accession>
    <name>A0A1U9NIB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cheY_3</name>
        <name evidence="5" type="ORF">STSP2_00675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67527">
        <property type="protein sequence ID" value="AQT67527"/>
        <property type="gene ID" value="STSP2_00675"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00675"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="4">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="145"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31285" checksum="32C028437DE57858" modified="2017-06-07" version="1">MGEPNLSGLKNGVFPRVSSVDRSEIIGDLWEFYVDSTTSLLTDLEAAAISLESEGSVEEDAADIRRILHSVKGDSGVSGLNDVYSLCHEVEGLFDEMADEPRAAADMILRVKDWISNVIEFIASGEFEEPEFEQSQAESEPGKLRALVVDDDPLCRKRVEMIISPYFHCDFAVTGLEGLQKFERSLGSGNRYDLVTLDINMPELDGHHTLQAIRSLESKNGIEGLDGVKIIMSTSCDESEHVFSAFRQGCEAYVIKREMGEKLPEQMVKLGLLKVTPTYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE1</accession>
    <name>A0A1U9NIE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpoD_2</name>
        <name evidence="8" type="ORF">STSP2_00847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00847"/>
    <dbReference type="EnsemblBacteria" id="AQT67699">
        <property type="protein sequence ID" value="AQT67699"/>
        <property type="gene ID" value="STSP2_00847"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00847"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30419" checksum="DA1D82D7FD1CF5D0" modified="2017-06-07" version="1">MAFDVTLKDYLKEIDESPLLTWEDEKELARRIHEEDDPLARERMVCSNLRLVVNIAKRFNGRGLTLGDLIEEGNIGLLRAVDSFDPEHGVRFSTYAAWWIKQGIKRSLLMNAQPIHIPTYMVELVNQYRQVSDKLKDELGRPASLKEMAEEMGLPQKKAKAVRDVVDMVDAGFQGDAASEENSGLDETLKDDKITVPDEILGSDEELAKAVDMLSEIDEREARILTLRFGIGGQEPLTLKEIGKVLGLTRERVRQIQASGLAKLNELMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF7</accession>
    <name>A0A1U9NIF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67528">
        <property type="protein sequence ID" value="AQT67528"/>
        <property type="gene ID" value="STSP2_00676"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00676"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15456" checksum="B7E26E91CB78DE71" modified="2017-06-07" version="1">MDQMKDSDMSNNILIVDDSVLMRAALKRTIDMVDLEIGSVFEAGDGEEALAVIEKERVDLILSDLNMPNIGGVELVEKLKHDERYAQIPIVVISTESSEVRVEDLMEQGVSDFLHKPFRPNEFRDVLIKNLGVCHGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL6</accession>
    <name>A0A1U9NIL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">15-cis-phytoene desaturase</fullName>
            <ecNumber evidence="2">1.3.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pds</name>
        <name evidence="2" type="ORF">STSP2_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00490"/>
    <dbReference type="EnsemblBacteria" id="AQT67346">
        <property type="protein sequence ID" value="AQT67346"/>
        <property type="gene ID" value="STSP2_00490"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00490"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="470" mass="53201" checksum="045239BBFF2D298C" modified="2017-06-07" version="1">MSQISVVILGAGPAGLSAGYELAKKGVAVNIVEKDSIVGGISRTVEHNGFRFDIGGHRFFTKMDRVNKLWDEILGDEFLTRPRISRIYYNHKFFDYPLKISNTFKNLGPIKSFEFFLSYLGSKIQPYPREDNLEQWVSNRFGRKLYRAFFKTYTEKVWNIPCDQIEAEWAAQRIKGLSFSSAVRAALLGNSNGKIKSLIDEFKYPRLGPGQMYETMAEKIREIGGKMIMNTRVTKLTKTDNTLASVEVTDSDGTTQTLTADHILSSIPLTELVQIIDDSVPDHVCRAAEKLSYRSLLTINLMMNRPESFPDTWIYIHSPKVKVGRVQCFKNWSPHMVPDSDQSSLGLEYFCTEGDSLWNAADADLVELGKNEIAQLELADPTTVFDAFVIRTPKTYPVYMANYREHLAAIKDYVTPITNLQCIGRNGMFKYNNMDHSILTGLLAADNILGADNDLWTVNTETAYHEQTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN6</accession>
    <name>A0A1U9NIN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67685">
        <property type="protein sequence ID" value="AQT67685"/>
        <property type="gene ID" value="STSP2_00833"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00833"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12512" checksum="BE1EF83FDA0C0035" modified="2017-06-07" version="1">MGENAVRDVFGRGELPWDRVARVFALLFAATLLLAGAGGIWITGQNRTLINSNEALTETNKSLTAEVERFSGELAEREAEIERLEERVDELEGEVLRLKVQNASLRAKAGEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIS8</accession>
    <name>A0A1U9NIS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuR</name>
        <name evidence="1" type="ORF">STSP2_00796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00796"/>
    <dbReference type="EnsemblBacteria" id="AQT67648">
        <property type="protein sequence ID" value="AQT67648"/>
        <property type="gene ID" value="STSP2_00796"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00796"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19515" checksum="F53566ABFFC25043" modified="2017-06-07" version="1">MGGMIEKGLVQIYTGAGKGKTTAAFGLAVRAAGHGNRVLIYQFLKPDSLVLGERKSAEKLGIEVRVLEHCWDMRRSLDDAAAVAEVREEVGAVLAEVGRLAAEKAYEVIVLDEIVFCVNSGLAEFAAVKEVVERRADGVEIVMTGRGASEELISAADLVTEMREVKHPFERGVGARKGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW7</accession>
    <name>A0A1U9NIW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00914</name>
        <name evidence="3" type="ORF">STSP2_00953</name>
        <name evidence="4" type="ORF">STSP2_03528</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67765">
        <property type="protein sequence ID" value="AQT67765"/>
        <property type="gene ID" value="STSP2_00914"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67803">
        <property type="protein sequence ID" value="AQT67803"/>
        <property type="gene ID" value="STSP2_00953"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70322">
        <property type="protein sequence ID" value="AQT70322"/>
        <property type="gene ID" value="STSP2_03528"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00914"/>
    <dbReference type="KEGG" id="alus:STSP2_00953"/>
    <dbReference type="KEGG" id="alus:STSP2_03528"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="41022" checksum="706DD031ADA01AF7" modified="2017-06-07" version="1">MDKYIGFDIDSKKTVACVVQKGKKDCFSTFETDPEKMKQFLKQQGSRGDRLHLTFEISGQAGYLHDQLRGHVQDVTVSNPTRMTWIYRTSKKNDRIDARKQAVLLSIDEVPKVHMPRLEVRQWRVTIQHRRKMVSRVCQVKNRIRAIIKANGFSRPVESGSWWKLANRLWMRGLACFEADAEQLWRMSLADMLEELNMLESQLKRVTNYLDRYLAGQSGGKLLMSVPGVGPRTAEAILAYTDDIRRFRRTKQYCAYFGLTPKLDESGSTRRLGHISKQGPSVVRWLLVESAWQAIRKSPALKAFYEKVMNGQKGRGKIAAVAVARKLLSIMRAMLVNGELFNEELVGRSCGFDMRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ51</accession>
    <name>A0A1U9NJ51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67817">
        <property type="protein sequence ID" value="AQT67817"/>
        <property type="gene ID" value="STSP2_00967"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00967"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5738" checksum="D78A3BFF029155AA" modified="2017-06-07" version="1">MKNGSQIRLDFNNSRYQAGDAIVSEADWVPGQLGEWVLKEWDSAVMRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ70</accession>
    <name>A0A1U9NJ70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67961">
        <property type="protein sequence ID" value="AQT67961"/>
        <property type="gene ID" value="STSP2_01113"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01113"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025579">
        <property type="entry name" value="DUF4357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14267">
        <property type="entry name" value="DUF4357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="48"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="32858" checksum="1220E61D2DAC7260" modified="2017-06-07" version="1">MAGKTIKLFLTEGKPNGLTVAELQQWTGIALACPRSELPKLNQRPEADKPGVYILTGQDEESQLPVAYIGEAENIRNRLREHHRSLDFWDRICFFTQKDDNLTKGHVRYLESRMIQVASDAKRTPLKNGSSPSPANIPLPESDLADMEYFLEQMQMVLPVLGVDLLQPQPVVTAEDAAENTAESPLFEFKARDAAASAKLMNGEFVVLEGSMARKESTASMHAYMEKMRRELLATGVLEEANGEQYRFTKNYAFGSPSTASGVIAGRASNGRKEWKVKDTRQTYGEWDEARLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ89</accession>
    <name>A0A1U9NJ89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate-selective porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01009"/>
    <dbReference type="EnsemblBacteria" id="AQT67857">
        <property type="protein sequence ID" value="AQT67857"/>
        <property type="gene ID" value="STSP2_01009"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01009"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012821158" evidence="1">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="422" mass="48084" checksum="9DE10A5419490727" modified="2017-06-07" version="1" precursor="true">MRHYLVLFLVVFGLVLTPASFAEQDQENDTNVEIVEPKEYGEQTPVEKSWDEQLIPLQFGKVKVGGAFRFNYYNKDWNDDTEGDVDLDTLRVNFDLVDADPWIGSAEYRWYIPQNRGGTGQSYSFIHHAWLGYEFTDEEQIQAGVQQVPFGILPYASHNWFFQLPYYVGLEDDYDLGFKYIKNDGDWNMQLAYYPMDEGQGRGYSKDSARYSYDVVESDSLNSANEERHQFNGRVAYTAQHGPDAVSELGFSGQYSAIKNNDTDQYGEHYALGLHLDGQYGPWDAKLEAIRYDYNLDNPAGVSEDIVVMGAYDAPYNVAATGTMLVAGIQKTIPVNWGEIEEINVYNDYSVLFKDDSDFENSYQNVIGMSFALNRFFVYVDFAMGKRHPWLTGGWTNSLADGSGADGGDWQTRFNVNVGYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA3</accession>
    <name>A0A1U9NJA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-ATPase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpC_1</name>
        <name evidence="4" type="ORF">STSP2_01163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01163"/>
    <dbReference type="EnsemblBacteria" id="AQT68009">
        <property type="protein sequence ID" value="AQT68009"/>
        <property type="gene ID" value="STSP2_01163"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01163"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="345" mass="39469" checksum="3A68FFA465FF3E0D" modified="2017-06-07" version="1">MKAIDEQSAIEFHRYPPIGGEDWSFAFATARARVLDTTLLTRSTFMDMINAPSFSEALAALSSTDYAMGESIDNFAQVEQRLLEVRTETRSTYANLLPEDYVELLRAREDFKNMRLAIRRIVTERPIGTEYSNDGNVPAEDFEDIFEKEDYSRFPLYLQEGVEQAILGYYNTKDIRQIDYGIDRAQAAYNIDKARELDSVFLLSLARMNIDLDNIRTMLRLKMAERSERDLFIEGGFVDISKFVQGLDAGYDTLGTIFFSTPYVEIIEEGVNYLNSNHSFLGLERKCEEYKLGFLQSTSSIAAGPQPVVAHFIRKESEIRAVRMVLSGKHNGMDTQLIKDRLPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC0</accession>
    <name>A0A1U9NJC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dgt</name>
        <name evidence="3" type="ORF">STSP2_00764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00764"/>
    <dbReference type="EnsemblBacteria" id="AQT67616">
        <property type="protein sequence ID" value="AQT67616"/>
        <property type="gene ID" value="STSP2_00764"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00764"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="41516" checksum="5FDE985502F99EE7" modified="2017-06-07" version="1">MLAQYAIIPDISRGRKYDTKPHPYRGDFERDRDRIIHSQAFRRLEGKTQVFVAGVNDNYRNRLTHSIEVAQIGRTIARALNLNESLTEAICLAHDVGHSPFGHAGEHTINEIMAPHGGFEHNLQAMRIVDLIEHPYPDFQGLNLMYETRLGLALHSSPYDKPETMSEFAELRCSLEGQIANVADRIAYNCHDLEDGLRSRFIEEPDLTGIELFDRARELINAPAITDIVVRKIRTAKAVIDMLVSDCIATSTRAIADANIATVRDVYRHTDPLIILSDDADAKLQKLESFLMKNMYKHDDLIKGFDTASGWLRGLFEKLCEDPEQMPSYYRGFIESEGLQRVVCDYIAGMTDRYCEQMVRRLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJC2</accession>
    <name>A0A1U9NJC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">murD</name>
        <name evidence="17" type="ORF">STSP2_00818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00818"/>
    <dbReference type="EnsemblBacteria" id="AQT67670">
        <property type="protein sequence ID" value="AQT67670"/>
        <property type="gene ID" value="STSP2_00818"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00818"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="119"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT67670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="457" mass="49093" checksum="F2508EFEAF2C6E82" modified="2017-06-07" version="1">MDRESLRGKTVVVMGLGRFGGGVDSAVFAAQAGANVIVTDLAPKGALDAAVKRLGEYENISLSLGGHVEREFATADVVIVNPAVDPRNQYVELAKRAGAVVTSQMEIFFQLCPAKIVGITGANGKSTTTALTYHILDKAAGAADKKYRKVWLGGNIGNRPLLGTLGEVAAEDVVVLEISSFQAEQLDRIGAAPWVSLLTNLTPNHLDRHGTFAAYCAAKESLFANQELSEDEPAVSIFCGEDPVAMKLYHKYEGQAGRKCVTFRAKDVHKGVRERFRLAGRMNLTNLAGAMRAAEQFGIGEEAVAKVIGGFEPLAHRLEFVGRVQGVGYYNDSIATTPVSTMAAIDAFDEEKVLIAGGYDKNIPFEELGLKIARKVKAAVLIGQTADSIAEAIKADMKAKTLVRVVDSLKEAVECASRLAERGDVVLMSPACASYDMFDNFQQRGELFKEYVGQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM1</accession>
    <name>A0A1U9NJM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68133">
        <property type="protein sequence ID" value="AQT68133"/>
        <property type="gene ID" value="STSP2_01288"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01288"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9380" checksum="4FD1800F60480CDA" modified="2017-06-07" version="1">MSSFKAVATITFIILIAGCAKYEMPAPATSHPAHPDAQTTPLDPVATTLAIDEENLPQTPPEFKRHKEHIQNKKSQQMDTPQQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM8</accession>
    <name>A0A1U9NJM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67944">
        <property type="protein sequence ID" value="AQT67944"/>
        <property type="gene ID" value="STSP2_01096"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01096"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12622" checksum="9774CAD16B2886C5" modified="2017-06-07" version="1">MPHRGDVFAPGMIIMWSGLLSDVPRGWSVCDGSNGTPDLRNRFVRGASSVGGIGGSQSHVHCHGGCTAFEGGCPVYVEFGCTYPVPFYGHSHGASPITETFEDNLPPYYDLIFIRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP7</accession>
    <name>A0A1U9NJP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c-type biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00885"/>
    <dbReference type="EnsemblBacteria" id="AQT67736">
        <property type="protein sequence ID" value="AQT67736"/>
        <property type="gene ID" value="STSP2_00885"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00885"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
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            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="2">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="31444" checksum="0B2BC85DA0096A06" modified="2017-06-07" version="1">MQNISLIENAFLFAGAAFYLAAAVLGMVRLYKEVNMPAGLLAVLIAFGSVMLAGVLFARGFEKGQVPLVDTFEFVLALTVVFSLAEFFTPHNLRKGWFEAVLSLLLFALTVTGFSLAGPVGTLDPAVKTPWVLVHGISMLVAAAAIFFSAAMAYLLLVGRSKLKSKNPLHVIGKMPSIEKLAKLNMLGLRLCTAAMTFGIVSGIGMALSQAEAIDMTAGDWLVDGKIILIMLVWVLLIIILLMNVFAGISSRAIAYVTIGAFLLALLAIVGVAVLGGGAHDFLAYAGSFRTEGGVLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR7</accession>
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    <reference evidence="5" key="1">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <property type="entry name" value="PEP-CTERM"/>
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    </dbReference>
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        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888757" description="PEP-CTERM domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30676" checksum="E9BB908150973C58" modified="2017-06-07" version="1">MTFEKFLTGIITITILTSCAHAGVWDTFDVPGAEGTRLAGIDGETILGHYLDSTGDWNNFLFDGDSYTTFAAPGATSTIARGIDNGRIVGNFQDGAGSGHGFIYDESGWTTLDAPGATSTEARGIDGENIVGTYWDSEGAHGFIFDGTNWTTLDMAGSTYTHLYDISGDNIIGNSEHDTYVYDGNQWSVLDGPDSPYGLNARGIDGDRIVGSLGYAGFFFDGKDWLELQVPGADPGLEWANDIEGDTIVGSYYDNGIKHGFIYTIPEPATFGLVGLGGLLLARRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJY5</accession>
    <name>A0A1U9NJY5_9BACT</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="3" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ST-NAGAB-D1</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VI_effect_Hcp1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012052742" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22475" checksum="1F4979A7A85A2DE4" modified="2017-06-07" version="1" precursor="true">MKRTALTLIVALLLCTSTSFAALNAYLRATGETQGNIAGSVTEPGLEGSIAVIGSIHEVVSPRDAASGLPTGKRQHKPFKITKTVDKASPLLANSLTSGEHFTQFELQYWQPAPDGTQILAYTIRLHNAQVCGIKQQISDTFTEQVSLTYDSIEWIWEPEAIAAQDDWDYQSSDIRLTDLSGDGIVDIIDLAILASDWLERTEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ8</accession>
    <name>A0A1U9NJZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68068">
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01223"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="DUF6259"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19773">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866386" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="799"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="3">
        <location>
            <begin position="799"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1279" mass="141101" checksum="8AAC3C836404F90A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK01</accession>
    <name>A0A1U9NK01_9BACT</name>
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        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00987"/>
    <dbReference type="EnsemblBacteria" id="AQT67836">
        <property type="protein sequence ID" value="AQT67836"/>
        <property type="gene ID" value="STSP2_00987"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00987"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="561" mass="62136" checksum="1E0C80D2FDF87CE2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK08</accession>
    <name>A0A1U9NK08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="gene ID" value="STSP2_00998"/>
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    <dbReference type="Proteomes" id="UP000189674">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AQT67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="26312" checksum="3271C46627E7BC7A" modified="2017-06-07" version="1">MGITARYYGWHCAGDFRRAAAGLFLLAVVFYGGGCYPEFVSPISTSLSRQMDDRVLGNWVRRIGGREVQQVSFFPRELSDWVDIVFVYGIDLRERYGGANVEVYQGYRALIDGDDYLCFRRRVKDEPNVLPEERVFYIVGYEVDDDVLTIRMLSLDEIEDVIDDGDLEGEVVVRNPDEGVFYDTILVTSSSERVTRVIDDEGIDRLSEDDDFHTKVFYRELDSWRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK67</accession>
    <name>A0A1U9NK67_9BACT</name>
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        <submittedName>
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    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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    <reference evidence="6" key="1">
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            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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            <end position="465"/>
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            <end position="502"/>
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        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK68</accession>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15487" checksum="865CAA7078882919" modified="2017-06-07" version="1">MASKYDDALNILAVFHFVIGGLMLFFASVPMVMVLVFNFANWFGGMHGPRMHDAVPATIFMTFMGFVVLSVVVLGICVISAGRCLMKKRGYVFCMVVAAILCIFFPLGTLLGVFTIIVLMQDEVRRMFEGGRSGVVESEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK76</accession>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </reference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01502"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22367" checksum="5D6FC1EFF558E778" modified="2017-06-07" version="1">MKEMTKKIIDIANQKGRITSADLVDIGASRTSLAYLASRGILRRIARGIYVPAGRIADNETFQSVSLAIPHGVICLLSALQFHEITTQMPVEVWIAIKRNQTVPKYKDNPLRIVYVSETHFACGIEEHQMQGVTVRVYSPAKTVVDCFKFRNKIGIDVAREALKESLAQGKANVDEIYRYAKICRMLNVMRPYLEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKD2</accession>
    <name>A0A1U9NKD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_12</name>
        <name evidence="5" type="ORF">STSP2_01353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01353"/>
    <dbReference type="EnsemblBacteria" id="AQT68198">
        <property type="protein sequence ID" value="AQT68198"/>
        <property type="gene ID" value="STSP2_01353"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01353"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="56709" checksum="1C804B475EBAD6E5" modified="2017-06-07" version="1" precursor="true">MNRRDFLKNCAAAASIAAAGPMAKLAQAKPATVKKPNVVIIYGDDVGYGDVGAYGAEKIPTPNIDKLAEQGLMFTDGHCTAATCTPSRFSLLTGIQAFRYGARVLPPNAPLIIPTDIMTMPKVFKQAGYKTGVVGKWHLGLGKKGEETNWNEEVKPGPLEIGFDYSFLLPYTNDRVPCVYLDGHKVVNLDPDDPISIGRKKKYEQSTEYPDGKKNREAMTYYESSHGHNNSVINGIGRIGYMYGGKSALWDDEGMADVFVDKMKDFVAENKDEPFFLYFSSQDIHVPRTPHPRFQGKSELGYRGDAMVQFDWSTGQIMKTLEEHGLTENTIVIFSSDNGPVYDDGYKDGTTVRTSTKPVDRGHRAAGPFRGGKYQIYEGGTRVPFIVRWPGKVKPGVSEALVNQVDLLASFAKLLNVELQTNQAQDSIDTLDAFLGKDKTGAPNIIEEARPLALRQGKWKYVRRNKNPELYDVENDIAEANNIAEKHPDRVKQMEARLAELIEKGRRKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE1</accession>
    <name>A0A1U9NKE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68285">
        <property type="protein sequence ID" value="AQT68285"/>
        <property type="gene ID" value="STSP2_01443"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01443"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="36" mass="3837" checksum="1F8AA733D0A5B859" modified="2017-06-07" version="1">MVTLLSQIVPTQPLIVFGSAAALVVIALTAWAIHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF3</accession>
    <name>A0A1U9NKF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68070">
        <property type="protein sequence ID" value="AQT68070"/>
        <property type="gene ID" value="STSP2_01225"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01225"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="28835" checksum="7DEC778027C3D366" modified="2017-06-07" version="1">MRKKGFTLIELLVVIAIIALLMAIMLPALGMVKEKARTVLCASNQKQTGLILFTYATDNEQEIPEPVMWERVSQGSGWTTWGDRMFYEFNYMDMTEQLYCPSTKVPPECTKKWDPDLTPEDFWNAGHFEWSGLRTFGLRVPVFDQATDTPIRLNQIKRPSNHYLLTDCSHEIEGGQMIASEKYQYYLFDYYHSFFMLHSAGANVLMADGSVSRKRETEIASDIKRGVIGPFLNDPFIYPSGETKRLEDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG1</accession>
    <name>A0A1U9NKG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01235"/>
    <dbReference type="EnsemblBacteria" id="AQT68080">
        <property type="protein sequence ID" value="AQT68080"/>
        <property type="gene ID" value="STSP2_01235"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01235"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="PTHR12872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002074" evidence="2">
        <location>
            <begin position="26"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU" evidence="3">
        <location>
            <begin position="127"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="NAGLU_C" evidence="5">
        <location>
            <begin position="456"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="744" mass="85152" checksum="07B44B33ADD45951" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG8</accession>
    <name>A0A1U9NKG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68433">
        <property type="protein sequence ID" value="AQT68433"/>
        <property type="gene ID" value="STSP2_01597"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01597"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025130">
        <property type="entry name" value="DUF4056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13265">
        <property type="entry name" value="DUF4056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="375" mass="42208" checksum="CB148CB2E5BCC25F" modified="2017-06-07" version="1" precursor="true">MNRSSRKTLVVPTILTILSIALLASGCSLTGKPRPRYGNVAADVAGTKFIELDDLGSHSRALPFGEHNGILYTARGGHIDTAHLRIAVDHTRWLHDEIHDHLTDGDTRFKFKMNVEPTRHYVNLEYPENWDTLSPAEKERIIDEISLDFSQYMAYNMVNWHEVLTWFKFKSLVFFSEFQSAFSWEDTYSNLLGTRIGAIALQDKTRSFDDAVTYALNRELQFLDVQSSKVAHDASESVKNKWYKGYLACDTIRRNMDIGVDDGYVSPALVPGVCGDPEPVSYPAPTIDSLVANGFKVDIEIKTNWLGWNKIARLVYDDPAGKPIKPLLHWPTILQYIHNDAIAQGCLATPTNRIHAAADEPRAPTTFKASKIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP5</accession>
    <name>A0A1U9NKP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68304">
        <property type="protein sequence ID" value="AQT68304"/>
        <property type="gene ID" value="STSP2_01462"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01462"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8686" checksum="838AEB6780B16F5D" modified="2017-06-07" version="1">MKRTKQLVLNKGSEKYIFRYEHGCEGELLDSLVAKASDADCPFDWFDAAVLSFKLTQKLIGEADKLLHNDPSDTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR2</accession>
    <name>A0A1U9NKR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68532">
        <property type="protein sequence ID" value="AQT68532"/>
        <property type="gene ID" value="STSP2_01697"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01697"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16505" checksum="0B69A40D529E2F2D" modified="2017-06-07" version="1">MSPSQHTNLIKRFSKASIGERIAAAAVFFAVIGGFYLLWLGATDRIEVGAITGVCGFKQKFGIPCPGCYITRSGEAFVQGHILEAFRVQPAGGVLFSFAALIGGISLIIAVLGIKFRLLDTNTFGRLVSYSVLFLVFVLACGWAVTLARDLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT6</accession>
    <name>A0A1U9NKT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein, PEP-CTERM locus subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01493"/>
    <dbReference type="EnsemblBacteria" id="AQT68334">
        <property type="protein sequence ID" value="AQT68334"/>
        <property type="gene ID" value="STSP2_01493"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01493"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="271" mass="30846" checksum="A903CFF99A66193E" modified="2017-06-07" version="1">MMKILEMLAETGTKATFFWLGWMAERMPQLVRRCADEGHEIASHGYGHILAYKAGRQAFREDIRKAKLILEGIVGQPVQGFRAPGFGITEKASWAFDVIKNVGYEYDTSVFPASRGHGGLLDAPLGLHFITTESGPLPEVPMSMVELFDKRFSIFGGGYLRLAPQGLIRWGIKQLHKQGQPLIIYVHPREVDPDHPRLPLGLVRRFKSYVNLRSTMPKLNWLCHNYSFFTMRELVADYVKSADREKLLKKLGNSEDKDWFDSVFFLKGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY4</accession>
    <name>A0A1U9NKY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00578</name>
        <name evidence="4" type="ORF">STSP2_00643</name>
        <name evidence="5" type="ORF">STSP2_00646</name>
        <name evidence="6" type="ORF">STSP2_01272</name>
        <name evidence="7" type="ORF">STSP2_01544</name>
        <name evidence="8" type="ORF">STSP2_01655</name>
        <name evidence="9" type="ORF">STSP2_02064</name>
        <name evidence="10" type="ORF">STSP2_02280</name>
        <name evidence="11" type="ORF">STSP2_02283</name>
        <name evidence="12" type="ORF">STSP2_02878</name>
        <name evidence="13" type="ORF">STSP2_03424</name>
    </gene>
    <organism evidence="7 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67431">
        <property type="protein sequence ID" value="AQT67431"/>
        <property type="gene ID" value="STSP2_00578"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67495">
        <property type="protein sequence ID" value="AQT67495"/>
        <property type="gene ID" value="STSP2_00643"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67498">
        <property type="protein sequence ID" value="AQT67498"/>
        <property type="gene ID" value="STSP2_00646"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68117">
        <property type="protein sequence ID" value="AQT68117"/>
        <property type="gene ID" value="STSP2_01272"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68384">
        <property type="protein sequence ID" value="AQT68384"/>
        <property type="gene ID" value="STSP2_01544"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68490">
        <property type="protein sequence ID" value="AQT68490"/>
        <property type="gene ID" value="STSP2_01655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68887">
        <property type="protein sequence ID" value="AQT68887"/>
        <property type="gene ID" value="STSP2_02064"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69093">
        <property type="protein sequence ID" value="AQT69093"/>
        <property type="gene ID" value="STSP2_02280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69096">
        <property type="protein sequence ID" value="AQT69096"/>
        <property type="gene ID" value="STSP2_02283"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69683">
        <property type="protein sequence ID" value="AQT69683"/>
        <property type="gene ID" value="STSP2_02878"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70218">
        <property type="protein sequence ID" value="AQT70218"/>
        <property type="gene ID" value="STSP2_03424"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00578"/>
    <dbReference type="KEGG" id="alus:STSP2_00643"/>
    <dbReference type="KEGG" id="alus:STSP2_00646"/>
    <dbReference type="KEGG" id="alus:STSP2_01272"/>
    <dbReference type="KEGG" id="alus:STSP2_01544"/>
    <dbReference type="KEGG" id="alus:STSP2_01655"/>
    <dbReference type="KEGG" id="alus:STSP2_02064"/>
    <dbReference type="KEGG" id="alus:STSP2_02280"/>
    <dbReference type="KEGG" id="alus:STSP2_02283"/>
    <dbReference type="KEGG" id="alus:STSP2_02878"/>
    <dbReference type="KEGG" id="alus:STSP2_03424"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="2">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT70218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="189" mass="22215" checksum="BC89EB7509697D80" modified="2017-06-07" version="1">MHISEIKYGDLQKLKEKARIETNAKQRDRYRVVALALEGWQTKAIMTKLDRSKNFVQRWCYFYRDGGIEAIAPKRQSGRPTKLPRKKEPELIKRIQDGPTDSDGGVCVLRGRDIRRILEREFGVKYSLFGVYDLMHRLGLSCLKPRPKHRKNDPEKMQQWLEQAPFLSKKSEQKTPKRKLRSGSRTKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL20</accession>
    <name>A0A1U9NL20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68206">
        <property type="protein sequence ID" value="AQT68206"/>
        <property type="gene ID" value="STSP2_01361"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01361"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8861" checksum="ECAB08F433B1AB32" modified="2017-06-07" version="1">MNNQVLRIFIALVVLGGGAAVWYFGAEINAATLFPKEGTAGEPATVAEPVIVKQVTIGGVERDEEGKLRKTYGEAEEAPEACPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD1</accession>
    <name>A0A1U9NLD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AQT68607"/>
        <property type="gene ID" value="STSP2_01775"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01775"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="47582" checksum="D44DEFAD3613DECD" modified="2017-06-07" version="1">MDSVVNFIKKYRSFIIPACILVVALILFVPLSMVRGSLAEKLEESARMGSKVSQLINSAPSELQAQVEQAYQDQHAAEVKKVDTIATQSTKRDLVSARLRNYILPEPAEPNPRLFDKFAAAYLDELRSLLDSMNALDAPSESEIDAELAKMSPGSYSRRNYGGRSRNSRNADDSQEAIIDALCEERAASISVYAGPEAFRWYDYWDNFEFDGINNALDDCWYSEISNWVYRDIVDTIKTVNAGSNSVQQSDVKRLIGVSFSSYADYPKKRETKFSNDWPDYVVDYTPGIFGVTPWTARKCDDNIDVIQFSTAVLINSKAVPDFLNALCSEKDHTFSGFRGDQEEQTFEHNQITVLEYAQGAIDPDAEVHDNYRYGDSPVVRLDLVCEYIFYKKGYDEIKPKSIKDYLKKATEEKKQTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD8</accession>
    <name>A0A1U9NLD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68729">
        <property type="protein sequence ID" value="AQT68729"/>
        <property type="gene ID" value="STSP2_01901"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01901"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11936" checksum="7D08E01B78132BAD" modified="2017-06-07" version="1">MNTQMNERMNGQINGKMNRPKARFQAGSVTVAVWENEFEFNGKPTRALRASIERRFKAKDGQWKSSSTFSRNDLPLAIHCMQKAFDYMVPNGFAGQKEVRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE6</accession>
    <name>A0A1U9NLE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone H1-like protein Hc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might have a role analogous to that of eukaryotic histone proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01726"/>
    <dbReference type="EnsemblBacteria" id="AQT68558">
        <property type="protein sequence ID" value="AQT68558"/>
        <property type="gene ID" value="STSP2_01726"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01726"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010886">
        <property type="entry name" value="Hc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07432">
        <property type="entry name" value="Hc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6518" checksum="938B2C834D181CF4" modified="2017-06-07" version="1">MQEYDQLKQLVSEIEDDVNKAEGGNKAAGTRVRKQMQTIKQAAQEVRNRVLELRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ1</accession>
    <name>A0A1U9NLQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01899"/>
    <dbReference type="EnsemblBacteria" id="AQT68727">
        <property type="protein sequence ID" value="AQT68727"/>
        <property type="gene ID" value="STSP2_01899"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01899"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15135" checksum="8B8944FD275EBD81" modified="2017-06-07" version="1">MKQIVHLKEPAGAITSPAMVFERVSSIDIDFDQENFLILTFTARQQVISAEVLFKGGIDTVIMDPRIIFKKALLDNAAGFLVAHNHPSGHLDPSDEDLQATRAIREAADLLKIRFCDHVIFNKSHYYSLNRSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT2</accession>
    <name>A0A1U9NLT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68694">
        <property type="protein sequence ID" value="AQT68694"/>
        <property type="gene ID" value="STSP2_01866"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01866"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9971" checksum="1318F96F7F5C9BA2" modified="2017-06-07" version="1">MDLREQNEYDWPPRPHVFPELMTPVEAAMFLRLDQTGHTPKSARRTLNYWRDRGELCATKYARRVWYLKSELEAFLSVKTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX2</accession>
    <name>A0A1U9NLX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68486">
        <property type="protein sequence ID" value="AQT68486"/>
        <property type="gene ID" value="STSP2_01650"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01650"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012188766" evidence="1">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35926" checksum="D4586C5710DB5F2B" modified="2017-06-07" version="1" precursor="true">MKKAMICLVLALTAGYTIAGPVNLHLINNDAKWAMHLDLAKARQTVAGKLLSLKADSKYPEEASEAVTEFEKYAGQGAAKLVEGITIFSTSEKPRSGIAILSGRLDQQFIDQQLKSEGLELTKYDGKNLYTKQNEDKGGVAFANKDLIVLGSDIEMLKRALDAISGKTPNAGSGDGLPALRNWEQGTFFGLDFDDLTPMRNVKPDADFLKSPEQMSFSAGEADGKLSLWANVRTPDPQRAMKIKQIAQGLVALAAIKTSELPELADMVESVQVWSQGSNVSASFDYPAQKLVELAAKYVTMHQEKIDCQIELSVEVEPKKPDEGSETNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY4</accession>
    <name>A0A1U9NLY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor CnrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnrH_4</name>
        <name evidence="4" type="ORF">STSP2_02139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02139"/>
    <dbReference type="EnsemblBacteria" id="AQT68962">
        <property type="protein sequence ID" value="AQT68962"/>
        <property type="gene ID" value="STSP2_02139"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02139"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="21143" checksum="655FBC35FAEF7117" modified="2017-06-07" version="1">MGNIPADNSNEKIGSPERFIKLVYRDQRRIFAFILTLVPNYSDAEDVMQDCLGVMWRKFGDFEPGTDFAAWGMKVAHYLVMDYRRKKAKKTIQFNDKLFRDVAEKAAENSRQTDKRVEALRNCIKRLRERERKLVNLRYFHGVRPQEIAKKLGLSLNSVYKSLSRTNSKLLACVEMKMGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM09</accession>
    <name>A0A1U9NM09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adhE</name>
        <name evidence="6" type="ORF">STSP2_02149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02149"/>
    <dbReference type="EnsemblBacteria" id="AQT68971">
        <property type="protein sequence ID" value="AQT68971"/>
        <property type="gene ID" value="STSP2_02149"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02149"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="29"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="5">
        <location>
            <begin position="478"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="880" mass="95348" checksum="E75A073096E086F0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM37</accession>
    <name>A0A1U9NM37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA_2</name>
        <name evidence="9" type="ORF">STSP2_01734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01734"/>
    <dbReference type="EnsemblBacteria" id="AQT68566">
        <property type="protein sequence ID" value="AQT68566"/>
        <property type="gene ID" value="STSP2_01734"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01734"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="186"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="44950" checksum="1560DD8FBFD667E1" modified="2017-06-07" version="1">MSQAANSLLSTSVYNFDKAAERLGLEAGIKRRLLGPKEKIELDINPILPCGKLINAKVFVVRHHDALGPAKGGIRMTPTVTLDDVCGLAMEMTWKTSLIGVPFGGGKSGIRLDPSKLSETDKEVVVRAFARGASHHIGPEWYVPAPDMGTNEMDMAHIRDCISYSQGVSITRGCFVTGKPVILGGIVGRREATGKGVVYTVAALCERIGRNLEGLRVAVQGFGNVGSVAAAEIGRLGAKVVGISDIGGGIVNDKGIDVQSLVGYAKETGSIQGFEGCADVDRDDILEIPCDVLIPAAAQSQIRSDNVDKIAADIIAEGANAPITPEADEVLKEKGVRIIPDILCNAGGVFVSYLEYTQETQRDQWTLREVEGRLRDRMSERFNEVYDYSREKNLSMREAAMDLAVGHVAEGVYARGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH7</accession>
    <name>A0A1U9NMH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="8" type="ORF">STSP2_02339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02339"/>
    <dbReference type="EnsemblBacteria" id="AQT69152">
        <property type="protein sequence ID" value="AQT69152"/>
        <property type="gene ID" value="STSP2_02339"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02339"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="359" mass="39129" checksum="D27F881724C26961" modified="2017-06-07" version="1">MLDALTTVLAASAAGRIFFIALAIIVGVFLLIFAFVIAVFFKLWLQAKLSRADVRFSELIGMYLRKVEPRTIVLSKITAIQAGIEISTRELESHYLAGGRVPNVVRALIAANRANIELTWNTATAIDLAGRDILDAVQTSVNPKVIDCPNPTQGRSTVDAVAQDGIQLKAKARVTVRANIERLIGGATEETIIARVGEGIVTTIGSAVNHKSVLENPDNISKAVLEKGLDAGTAFEILSIDIADVDVGDNIGAQLQKAQAYADQERAKAEAEKRRAMAIARKEEMKALVHENRAKVVLAEAEVPKAISQAFRDGHLGIMDYYRMKNINSDTAMRDAIAGTSDEEQQEQQKRRQGEREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK3</accession>
    <name>A0A1U9NMK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69027">
        <property type="protein sequence ID" value="AQT69027"/>
        <property type="gene ID" value="STSP2_02206"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02206"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="96" mass="11503" checksum="4FD401BF0CE9D7C0" modified="2017-06-07" version="1">MIQCKDCELCEIGEDGRRTFKCNPFSNVKEPECLQKWQILKLDMLLAGYRSMLGFQQKMAPMQDRIMKYVQRELDDIDESESWKFDDEDESDYDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN5</accession>
    <name>A0A1U9NMN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cycloisomaltooligosaccharide glucanotransferase</fullName>
            <ecNumber evidence="5">2.4.1.248</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 66 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.248" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02400"/>
    <dbReference type="EnsemblBacteria" id="AQT69212">
        <property type="protein sequence ID" value="AQT69212"/>
        <property type="gene ID" value="STSP2_02400"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02400"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14745">
        <property type="entry name" value="GH66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025092">
        <property type="entry name" value="Glyco_hydro_66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13199">
        <property type="entry name" value="Glyco_hydro_66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956675" evidence="3">
        <location>
            <begin position="26"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="662"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="785" mass="88207" checksum="CEA9650349CB5C7A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN9</accession>
    <name>A0A1U9NMN9_9BACT</name>
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        <submittedName>
            <fullName evidence="4">Putative Ig domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">STSP2_02378</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02378"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadg"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010735672" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="609"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="871"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1323" mass="142802" checksum="63AA70B30517D7C2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69034">
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        <property type="gene ID" value="STSP2_02215"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02215"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012120708" evidence="1">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="578" mass="64642" checksum="20F9F12A37BC874B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW0</accession>
    <name>A0A1U9NMW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69074">
        <property type="protein sequence ID" value="AQT69074"/>
        <property type="gene ID" value="STSP2_02260"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02260"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="393"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="542" mass="59107" checksum="A4D82CB762B618B0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX4</accession>
    <name>A0A1U9NMX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD-box ATP-dependent RNA helicase CshA</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cshA</name>
        <name evidence="11" type="ORF">STSP2_02452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
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    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02452"/>
    <dbReference type="EnsemblBacteria" id="AQT69263">
        <property type="protein sequence ID" value="AQT69263"/>
        <property type="gene ID" value="STSP2_02452"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02452"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="226"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="392" mass="43968" checksum="94D9B025887AC9E8" modified="2017-06-07" version="1">MKIDELNLKPQILNGLKKMGFSDLTPIQEATYEHILAGRDLVGLAETGSGKTAAVGIPVVQSVDPDLDAVQSLIIVPTRELALQYVSEVSDIAKLTDVAAFAVYGGFDMNIQLGKLEHGVQILVATPGRLIDLLYNSPLRLNEVRTLVLDEADEMLNMGFVTDIEFVMSCLVHEHQTLLFSATMPKEIKQLTSKYLKDPVEVELIEERQSPQSLEHQFEQVSKNDHFDKLLNVLKQDDLEQAIVFCNSRRTCENVFKKLKHKIDSAEIIHGGIDQSKRTSLFNRFKKKKVKVMIATDIAGRGLDFSHTSHVINYDFPKGPEPYTHRTGRTARMGRRGVAVTFYGRGDLRALKSIIRKTHIKPVWRGEAPDLDKIGGGRGRSGGRSQKRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN53</accession>
    <name>A0A1U9NN53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">STSP2_02123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02123"/>
    <dbReference type="EnsemblBacteria" id="AQT68946">
        <property type="protein sequence ID" value="AQT68946"/>
        <property type="gene ID" value="STSP2_02123"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02123"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23697" checksum="4847495508AA5CA3" modified="2017-06-07" version="1">MNPSYITFIVASYLIGSIPFGVLIAKAHGKDLRKIGSGNIGATNVSRALGKNWAYICFALDVLKGLAPTLAFSFVIERPPSLVQLWVWLAVGAAAVIGHIFPIYLRFKGGKGVSTSLGMILGLYPYYTMTGLLVFVIWTAAVLAWNYVSLASIIAACCFPLILLVAMLAHSQWDITQLWPLIVAAVVMSALVILRHRTNIKRLFAGTENKIMQKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN83</accession>
    <name>A0A1U9NN83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
            <ecNumber evidence="1">5.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaM</name>
        <name evidence="1" type="ORF">STSP2_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02375"/>
    <dbReference type="EnsemblBacteria" id="AQT69188">
        <property type="protein sequence ID" value="AQT69188"/>
        <property type="gene ID" value="STSP2_02375"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02375"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="13450" checksum="73EB9FE77394E5B8" modified="2017-06-07" version="1">MRRFGWVIGLKEDRIEEYKKLHAAAWPEVLEMISECHFTNYSIYLRKLPDGKYYLFSYLEYTGDDFEADCSKMAADETTQKWWDVCKPCMEPLPDRAEGEWWADMEEVFHCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND3</accession>
    <name>A0A1U9NND3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-W factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigW_2</name>
        <name evidence="8" type="ORF">STSP2_02205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69026">
        <property type="protein sequence ID" value="AQT69026"/>
        <property type="gene ID" value="STSP2_02205"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02205"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="188" mass="21769" checksum="4D3733F87E50DCD6" modified="2017-06-07" version="1">MDHSKVDAIIQGCKRGNKDDFSRLVDIYAGPCYGYFYRLTGDKSLSDDLLSELFVKLIDRIQSYNGGSFKSWLFTIASNLWRDHLRSQYRRKRLAEEKSLYVSEFGHGDTEKVELHDELQVALKQLDPDTAEIIVLRYYSEMSFKELSKARKEPIGTTLAKVHRGLKKLKQIMGEPNENEQRKSENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF6</accession>
    <name>A0A1U9NNF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase YvaA</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yvaA_2</name>
        <name evidence="4" type="ORF">STSP2_02463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69274">
        <property type="protein sequence ID" value="AQT69274"/>
        <property type="gene ID" value="STSP2_02463"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02463"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211450" evidence="1">
        <location>
            <begin position="30"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="182"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="448" mass="50836" checksum="643620D00E19A88B" modified="2017-06-07" version="1" precursor="true">MSDKMNRRDFMRSTAAVSAGLAIAPGLFAAEAKEKADDINVAILGAGSQGQVLLDSCLRIPGLRFKAVCDIWEQYNLRKVHRLLMKYRHENNAYIDYREMLDKEKDLDAVIIATPDFWHSEHAIACMEAGLDVYCEKEMSNTIEGAKKMVEAQKKTGQLLQIGHQRRSNPRYLYCKDKLMTNDEILGQVTMINGQWNRSARPDLSAPERYHIPQKVLKQYGFDSMRQFRNWRWYRGLGGGPIVDLGAHQIDVYNWFLGAHPKAVIANGGTDYYDKETHEWYDVVMAVYEYETKKGTVRAFYQTGTTNSNGGYYETFMGDKGTLTISEASSRGALYPENLADIKVAQKWEKFVSSGLVKEPVKEDTGGDEDALLDVRETVAPPAYEIPVTMEKKYHQPHLENFFDAMRGKVELNCPAEDGYASAVTVLKVNEAIQAKKRLEFKPEDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH9</accession>
    <name>A0A1U9NNH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00138</name>
        <name evidence="4" type="ORF">STSP2_02483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67000">
        <property type="protein sequence ID" value="AQT67000"/>
        <property type="gene ID" value="STSP2_00138"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69294">
        <property type="protein sequence ID" value="AQT69294"/>
        <property type="gene ID" value="STSP2_02483"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00138"/>
    <dbReference type="KEGG" id="alus:STSP2_02483"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="2">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="189" mass="22187" checksum="BEC28779381122BF" modified="2017-06-07" version="1">MHISEIKYGDLQKLKEKAQIETNAKQRDRYRVVALALEGWQTKAIMTKLDRSKNFVQRWCYFYRDGGIEAIAPKRQSGRPTKLPRKKEPELIKRIQDGPTDSDGGVCVLRGRDIRRILEREFGVKYSLFGVYDLMHRLGLSCLKPRPKHRKNDPEKMQQWLEQAPFLSKKSEQKTPKRKLRSGSRTKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI6</accession>
    <name>A0A1U9NNI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose--fructose oxidoreductase</fullName>
            <ecNumber evidence="2">1.1.99.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gfo_2</name>
        <name evidence="2" type="ORF">STSP2_02703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.99.28" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69512">
        <property type="protein sequence ID" value="AQT69512"/>
        <property type="gene ID" value="STSP2_02703"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02703"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047061">
        <property type="term" value="F:glucose-fructose oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="335" mass="38207" checksum="60A74EED0485A0D3" modified="2017-06-07" version="1">MLLGFDSKEVRVCIAGMGKMGGYHLHALEQLMAGQYEPYYKGDVEKQLSKIRIAGVCDVDEEHLASFPQYDHYVDYAKMLDDSKPDIIVIAVPTKLHFEFVAAALKKGIHVLVEKPLVTRKAEMDELVRLAKENGCKLISGHVERYNPVAIKIVSMIRERQVNPQSYSFRRTQKHHERIPDDIIVDKVVHDLDLARYFFGPVKGVNVERSRRFEGQVYEAQINVEHQSGVQGELFVSWLVEADAKERTVRIECEDCEVRGDFKEKKLRVDGKEVDCEVPGWITPSNNQIKDELVDFIMYCSESTEQARLVEPLLSLGEVEESISLIEQIARSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM8</accession>
    <name>A0A1U9NNM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69334">
        <property type="protein sequence ID" value="AQT69334"/>
        <property type="gene ID" value="STSP2_02523"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02523"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012753018" evidence="1">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="215" mass="24431" checksum="0FBB4D9EA8A1ED90" modified="2017-06-07" version="1" precursor="true">MRKTLLSVLFIAVCVSIPVGLCNAYPKPAVVQDLDEWTLDVQFDQPKQIVVDLPNVGKQRYWYTILTVTNNTGSEVPFYPRFELMTDTFQVIPAGRKYRRGVFAQIKRLNQGKYPFLEAMDDIVDHKVLAGEDNTRDIAVIWPDFDPNAKNVKLFFGGFSNETAVVQHPTKLNEQGEPAKIHLQKTLELNYSIGGDPSLRSQAGLAFKNKQWVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS8</accession>
    <name>A0A1U9NNS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69270">
        <property type="protein sequence ID" value="AQT69270"/>
        <property type="gene ID" value="STSP2_02459"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02459"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160474" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="138"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32723" checksum="A5DFF5A0BB854591" modified="2017-06-07" version="1" precursor="true">MTKRILTTFVMFGFLCAAVVTLSSCGKSEPAAEEETQTTTQGETETEEAAVEETPEEPAKEAEAEEAAEAEEEAEEVAEEPAAEEVTDAVEPEAGTPSTDLVPLPLELPQPMFQGTPADIKVPGGKLEKPRGKPRPDFLAPEGVKNVALNKPVSASDEFPIIGEIEMLTDGDKEAADGSYVDMGPFHQYMTIDLEDTYEIYAIVLWHFHKQPRAYYDVVVQVSNDPEFAEGVTTLFNNDHDNSIGLGAGDDYHYVETSEGKLIDAKGVEARYVRFHSNGNSSNDQNHYIEAEVYGKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX3</accession>
    <name>A0A1U9NNX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrate/nitrite sensor protein NarX</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">narX</name>
        <name evidence="4" type="ORF">STSP2_02624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02624"/>
    <dbReference type="EnsemblBacteria" id="AQT69434">
        <property type="protein sequence ID" value="AQT69434"/>
        <property type="gene ID" value="STSP2_02624"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02624"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="691" mass="77283" checksum="AF3897FA1CCF8621" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY5</accession>
    <name>A0A1U9NNY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE_1</name>
        <name evidence="10" type="ORF">STSP2_02415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02415"/>
    <dbReference type="EnsemblBacteria" id="AQT69226">
        <property type="protein sequence ID" value="AQT69226"/>
        <property type="gene ID" value="STSP2_02415"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02415"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35977" checksum="DF1C3218A35ACB01" modified="2017-06-07" version="1">MNILVCGGAGYIGSNMTAMLARHGHNPVVYDNLSKGHKSAIRNAQFVRGDLADYDLLVETIKKYSIDAVMHFAAFIEVGESVADPLGYYYNNFCNARNLLQAMVDTGVNKFVFSSTAAVYGEPETIPITEDIAKQPINPYGDSKRAVELMLSFLSKTGKMNYAALRYFNACGAGEDGTLGEDHQPESHLIPLIIQAAMGKREDIKIFGNDYPTHDGTCIRDYIHIEDLCKAHLLALDKLDDEAELIFNLGNGKGYSVLEVIETVKKVSGKDFTVITGDRRPGDPPVLTADASRARQQLGWTTDFPELEIIVESAWKFHNANPDGYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP40</accession>
    <name>A0A1U9NP40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase, monofunctional class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02559"/>
    <dbReference type="EnsemblBacteria" id="AQT69370">
        <property type="protein sequence ID" value="AQT69370"/>
        <property type="gene ID" value="STSP2_02559"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02559"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="73"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16341" checksum="20ED9CEA7B63E248" modified="2017-06-07" version="1">MMYLETQFSVFMINKPGVLAQLLDEFARSNVNIQALTMMDSVEHGVLRVVAKNHKKVCQLLTDLNMQFSETDVLCVNLSNKSGALAEITNKLAKAHINISYAYCTAGARGGRTTGVIKVADVKKAMKVLQGGGKTTTKKKKPVKRSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP68</accession>
    <name>A0A1U9NP68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69699">
        <property type="protein sequence ID" value="AQT69699"/>
        <property type="gene ID" value="STSP2_02894"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02894"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30650" checksum="0051BBBFC574537C" modified="2017-06-07" version="1">MKENLKEYMKPAFLVCVAILAVAAFSKEAVVKYTGVKLNKKALPLQASFSELDKSDMGRYKVVDKSDIPKEIEDELGAQDYIKWVLEDTEAEEFSPTRFCLLFITYYTGNPDQVPHVPEECYVGGGNSRRESKVVTLDLAKSNGEAGSIPAELETKLLMFARESKDIFRTSTEFPVMYFFKTNGQYASGRGGVRAIMGRNFTSEYSYFSKVEWNFYGGNAGRLIYPDEEQTIEASENLMKTLLPLFEKKHWPDWEKANSESDDADEFQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP80</accession>
    <name>A0A1U9NP80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69645">
        <property type="protein sequence ID" value="AQT69645"/>
        <property type="gene ID" value="STSP2_02839"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02839"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10770" checksum="1AA58D7748FAD34B" modified="2017-06-07" version="1">MNSTDCDRVKRLRTDPPSEKRLTEVFQQESERFADELHKNLNHTPLGKLLGMIAALPEVRHEKVLRARDRIETGEIDKDLDAAMDRMLEDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP96</accession>
    <name>A0A1U9NP96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ORF">STSP2_02620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02620"/>
    <dbReference type="EnsemblBacteria" id="AQT69430">
        <property type="protein sequence ID" value="AQT69430"/>
        <property type="gene ID" value="STSP2_02620"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02620"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30113" checksum="EA4643855FA37020" modified="2017-06-07" version="1">MLGRDLMEELRKCGYDARGFDLPELDICDEDALKRVIQPESLIINCAAYTNVEKAESEPELAYKVNAEAVARLGKIAADMKSRVIHISTDFVFNGKSETPYTEDDEPDPVNVYGASKLEGEKLLKQSGCEHLIMRVQWTYGRHGSNFITKLLELAKTRDRLKVVDDQKGSPTSTIEAVKTICKLITLDRFPKGIFHFAALGYASRFEVARFIFVHAGSNVEIEPCDSSEFPTAAQRPLNSCFDCGKLTALVGEPARSWQEPLAEFIDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB2</accession>
    <name>A0A1U9NPB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">STSP2_02535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02535"/>
    <dbReference type="EnsemblBacteria" id="AQT69346">
        <property type="protein sequence ID" value="AQT69346"/>
        <property type="gene ID" value="STSP2_02535"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02535"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="376" mass="41890" checksum="6A4AAED6EC230FF8" modified="2017-06-07" version="1">MKAILLLEDGRVFEGRGFGAKGTTCGEVVFNTSMAGYQEILTDPSYNEQIITMTYPQIGNYGTNDNDWESDRVQVAGFIVKENCDYPSNWRSNRSLSDYLKKNKIVGLEGIDTRALVKHIREKGAMRGVISSAELNVQKLQAKLDKYPGLVGRDIVKNATISKPFVWKEGLWDVEADKPEDTGKPKYKVVAYDFGMKHNILRNLASRGCEVHVVPADTPAGRIMQRKPHGIFLSNGPGDPAAVAYAVENIKKLLGKAPIFGICLGHQLLSLALGGTTYKLKFGHRGANHPVKNLRTKEIEITSQNHGFCADLESLKETDVELTHMNLNDNTLEGIYSKKLGAFSVQYHPEASPGPHDASYLFEEFTRLMDEWKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB4</accession>
    <name>A0A1U9NPB4_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Putative membrane protein EpsK</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">epsK_1</name>
        <name evidence="2" type="ORF">STSP2_02640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69450">
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        <property type="gene ID" value="STSP2_02640"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02640"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="525" mass="57657" checksum="B5DDECA9D0B87774" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE3</accession>
    <name>A0A1U9NPE3_9BACT</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69588">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="24647" checksum="A3C0D79EBFBABF86" modified="2017-06-07" version="1">MYKINLINKKKHKKKARILPTIMWTILLAVPIGGAVYIALEYWATEYKITIANSQLNDVEADLQKWHEDIEFLQQANTTIHASNKQLTELAALLERQVQWTSILGDLVDILPEKMIMQELTVSRISKTIRTEKENPFTGKKEKELIERGLCSSLVCQNSDAADQDVKIYIKKLWLSEELGNAVKDIRMTSLQDTKEKGVNGSKYEIECILSPGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT0</accession>
    <name>A0A1U9NPT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69923">
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        <property type="gene ID" value="STSP2_03123"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03123"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6989" checksum="2D8A9CDD8F4781A5" modified="2017-06-07" version="1">MTIRIHHPTKSKPQNNKHDSPAQKSANYDLTREPLIQDIVTQLRNKDILYLIALHEWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV3</accession>
    <name>A0A1U9NPV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_22</name>
        <name evidence="6" type="ORF">STSP2_03014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69817">
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        <property type="gene ID" value="STSP2_03014"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="535" mass="61857" checksum="096019B58FD1ACE8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ20</accession>
    <name>A0A1U9NQ20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atsA_23</name>
        <name evidence="7" type="ORF">STSP2_03235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70033">
        <property type="protein sequence ID" value="AQT70033"/>
        <property type="gene ID" value="STSP2_03235"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03235"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012866388" evidence="4">
        <location>
            <begin position="29"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="395"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="508" mass="56649" checksum="EF1FBB143C83D506" modified="2017-06-07" version="1" precursor="true">MNRRDFLKQTCMLGASAVLAGSAMTSRAYGGANAKKPNIIFFFIDDMGWQDTSEPFHTEVTALNQRYHTPNMEQLADSGMKFTQAYACAVCSPSRISLMTGMNAARHKVTNWTLRPNASPDHPHPTLNPPAWNVNGISPVPDVDRTAYVKTLPMFLQKTGYHTIHVGKAHFGADGLAGEMPENLGFDVNIAGHCAGGPGSYHGTNNFSAAFRNGSRIWDVPDLEEYHGQDIYLNEALTIEALEAVDQAVAADKPFYLYMSHYAIHAPWEKDNRYYQKYIDAGLDDFDATYASMIESMDKSLGDICSHLKSKGIDDNTIILFMTDNGQPSQADRNLPLRGHKLTPYEGGSRVPAMVKWPGVVEPGSVCDDYIIIEDIFPTILEMAGLKDCPQIGGKVDGVSFVPLLRQKPGYPKDRAVFWHFPHNYGTGKPYSSIRKGDWKLIYFHADQRYELYNLAEDIGEANNLFTQRKDIAQRLVEELRLFMIDAEAQMPTYKTSGKPVPLPAFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ35</accession>
    <name>A0A1U9NQ35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar transferase, PEP-CTERM/EpsH1 system associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69626">
        <property type="protein sequence ID" value="AQT69626"/>
        <property type="gene ID" value="STSP2_02820"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02820"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="38491" checksum="5D7F17B1B0680ACE" modified="2017-06-07" version="1">MTQKHIKIAALTAGKNTPSTRFRIRQYAERLESHGVTVEEHIPFFEKSCGLPSPFKAAARIPALFRSRSADLIWIGKELVQGYPTFEKLLKRPRVLDADDAIWLNFPLGRVAAPFIARNMDTVVAGNSYLADHFSQYNQNVHIVPTAIDLNRYTPRQIDTEPETFTIGWTGLACNNKYLDDIEQPLKEFLTAHQNTRLVVLSNKPWKHNSLPPDQVEFIRWTPENEATTLHRFSVGIMPLPDNKWTRGKCSFKMLQYMAAALPVIASPVGMNKDVFQKGEIGFPADTPKKWRQALEDLYKNWNAQKQMGQTGRLIIEQNYNADTIAAQLAKIFHTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ56</accession>
    <name>A0A1U9NQ56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor YlaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ylaC_2</name>
        <name evidence="4" type="ORF">STSP2_03241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70039">
        <property type="protein sequence ID" value="AQT70039"/>
        <property type="gene ID" value="STSP2_03241"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03241"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="21063" checksum="5BE1CE627CF4DDC1" modified="2017-06-07" version="1">MSESSQNNRNREFFELYGQSQTRILSFLFAMVHNESDAQDLLQDTAAAMLENFSRFERGSNFTAWGITIARNKALNFLRKNSKSRPLLNPDLYTRIAELEMSEMEEEERLAERLAVLKKCRKKLDGRDQEILSLKYYQGYPMSKIAEVLGRSKTGIYHTLARIHNLLYRCIQNNLATGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQG6</accession>
    <name>A0A1U9NQG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69968">
        <property type="protein sequence ID" value="AQT69968"/>
        <property type="gene ID" value="STSP2_03168"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03168"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17929" checksum="EB5BCECB1801C3AD" modified="2017-06-07" version="1">MIVMELEMRGSLEGKKMRFKSATKAALKTVVKSWHKQALPKHFKSGAKRRYDYDARHPRYARYKRRKGLPPLVFSGRSKKQLTRTIKVVDSGGVVKGKFVTDNRVRYFWMTPPGHPKKGEELIATSKSEQRDMAAAITEMIEDDLEKVNDKKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL6</accession>
    <name>A0A1U9NQL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03427"/>
    <dbReference type="EnsemblBacteria" id="AQT70221">
        <property type="protein sequence ID" value="AQT70221"/>
        <property type="gene ID" value="STSP2_03427"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03427"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024787" evidence="1">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30172" checksum="33C9F8567D7167D0" modified="2017-06-07" version="1" precursor="true">MKHCIALLIVILVTATPVFAGTQENTQSGSLLDEDYQASFDEVKPLDALWDDIWTLPDVIEENTVEILDNPDYVNALLMAGGASIAMHASGADDDIADNFEDHQALRDDWADEGTYLVGGPGFHFAATGLWYLFSHANQDEINKKNAWTMMKALSVTGFWTLTAKVIRNNDTPNGKDLAWPSGHTSSSFTVAAVLDELYGPNVGIPAYLGAGFVGFRMMDSGDHWGSDVVFGAVLGYIVGHHVAGEDKLPQVGGFDVIPFSGVDGKEEYMGIGLHRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP2</accession>
    <name>A0A1U9NQP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03435"/>
    <dbReference type="EnsemblBacteria" id="AQT70229">
        <property type="protein sequence ID" value="AQT70229"/>
        <property type="gene ID" value="STSP2_03435"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03435"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="223" mass="25860" checksum="3C79FB7C2579FA55" modified="2017-06-07" version="1">MPRQKRIAKGNIVYHVLNRANGRLRIFKKDDDFRAFEQILAEAAERFDMRICGYCIMSNHWHLVLWPRADGDLSAFMKWLTGTHSHRWHAAHRTVGIGHLYQGRYKSFPVQDDTYYLTLMRYVESNPLRAKLVKRSADYLWSSLANRLGKDSPLELSDGPMPLPRRWTKLVDGAADLPEDEIKTCIQRGRPFGDSDWTHQTAKALSLESSLRPRGRPRKTTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR16</accession>
    <name>A0A1U9NR16_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70227">
        <property type="protein sequence ID" value="AQT70227"/>
        <property type="gene ID" value="STSP2_03433"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03433"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6352" checksum="1E1100591A931288" modified="2017-06-07" version="1">MFGIESKGVLLAYLLCIVSTLICVVYGLITWNRGDEEVEPDDVQWAQEEASIEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRE6</accession>
    <name>A0A1U9NRE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor YtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytrA_2</name>
        <name evidence="2" type="ORF">STSP2_03494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03494"/>
    <dbReference type="EnsemblBacteria" id="AQT70288">
        <property type="protein sequence ID" value="AQT70288"/>
        <property type="gene ID" value="STSP2_03494"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03494"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="40333" checksum="1E80BC3290688E67" modified="2017-06-07" version="1">MIVNIGLKYQAKVFGDIRMAAEEIQISIERKRGVALYTQIKDAICEAISRSPDTKRLVLPPQRDLASRLGVSRNTVSMAYAELEREGIVASYVGKGTVVLRGVTEVEDHSRRELLERTIRHSVEESLAMGFTLQDYRECVEHFLKDKEEKFGHLKLIFVECNREQLLYFSEHLLSDPGVSVVPLLLRDIRSKNKDVMAELKDAECVVTSFYHKEELENLLPDKGPPIVGIHLQPEMSTIVQIARIPRSHTLGVVAGSKQFLDEMFRTLEDMELKEDMMEVYHRPEGGEPLRNFVDRMDSLLVSPSRKDEVKKFSKDKPVVEFLFAPDKTSINSIRVALLELRQHGDNGEDLKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRM1</accession>
    <name>A0A1U9NRM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70176">
        <property type="protein sequence ID" value="AQT70176"/>
        <property type="gene ID" value="STSP2_03381"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03381"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="21887" checksum="50A91BB792368B38" modified="2017-06-07" version="1" precursor="true">MAEFLFSTVIISLSGVMAPGAMTAATLAHGTRHRHAGALITAGHAVVELPLIAFLLIGLATFLQNPAVKIAVGIAGGGFLCYMGYGMLKDMRNAEFKAGSMGSQKPLTAGIILSATNPYFLIWWATIGVKLALEAKEFSMLALVLFATLHLTCDLIWLEFLSHASYQGSKIMGDKLQKWVLGICGTALLFFGIKFLYDAATDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRS5</accession>
    <name>A0A1U9NRS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQQ-dependent catabolism-associated beta-propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_03516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03516"/>
    <dbReference type="EnsemblBacteria" id="AQT70310">
        <property type="protein sequence ID" value="AQT70310"/>
        <property type="gene ID" value="STSP2_03516"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03516"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012888763" evidence="5">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="386"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="503"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="601" mass="63798" checksum="CBD0CBA3BFEF8507" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM2</accession>
    <name>A0A1U9NGM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar export protein FliJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66898">
        <property type="protein sequence ID" value="AQT66898"/>
        <property type="gene ID" value="STSP2_00036"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00036"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="17417" checksum="3BF06D98A1F988F7" modified="2017-06-07" version="1">MARFVWRLDKVLNAKGKLEQAKEAEIHAVAAEIVRVDRQIGSIRSKLRVMGGKLGELGGAERLQKQQMYLSHAQYSEQEITQLGHKRGELEKIRQEKTAELAEIRRSIKVLEKLREKAKQEWTEEQEKIEQKETDDLNNTRSARRLAGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGM8</accession>
    <name>A0A1U9NGM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66908">
        <property type="protein sequence ID" value="AQT66908"/>
        <property type="gene ID" value="STSP2_00046"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00046"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3590" checksum="EB12035BB0A52CC9" modified="2017-06-07" version="1">MGAGFEYNACVLNGKTVQAGSDEKERISGQSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY9</accession>
    <name>A0A1U9NGY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67189">
        <property type="protein sequence ID" value="AQT67189"/>
        <property type="gene ID" value="STSP2_00332"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00332"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18861" checksum="0F3FA910B1427676" modified="2017-06-07" version="1">MRTQHKHTLCHPGPRAGIQRTLRARMHAQKHFSTTCNATASIAPHRTHTKSCHYEERSDPATSTRCLSSAEGGPRDHHEHTCTHKTLLHNLQRHRIHSVPSNPHTKSCHCDQRSDTTISNAQKSWHAHNKHNRPSDKVVIRLRRTQHKTNRSLPPSSRTPIRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH28</accession>
    <name>A0A1U9NH28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00183"/>
    <dbReference type="EnsemblBacteria" id="AQT67044">
        <property type="protein sequence ID" value="AQT67044"/>
        <property type="gene ID" value="STSP2_00183"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00183"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013092473" evidence="1">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="681" mass="76998" checksum="29899B7B1B2E5AD2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH78</accession>
    <name>A0A1U9NH78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pcm</name>
        <name evidence="3" type="ORF">STSP2_00298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00298"/>
    <dbReference type="EnsemblBacteria" id="AQT67155">
        <property type="protein sequence ID" value="AQT67155"/>
        <property type="gene ID" value="STSP2_00298"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00298"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24524" checksum="DBA4158584533EE3" modified="2017-06-07" version="1">MVSINAKAKHAVERRKMVQHQLAARGINDPAVLEAFEDIPREIFLPPQYESQAYHDNPVPIGSGQTISQPYIVALMTEKLQLDKNCDVLELGTGSGYQTAILATIARRVYTIERYNQLSETAQANIAHLDLPNIEYCIGDGSKGWPEHRRFDRIIATAAMPKIPQPLIDQLKPDGLIIAPVGTMTAQELILARKTDQGLKTHQITPVRFVPLLGEYSFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA8</accession>
    <name>A0A1U9NHA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67299">
        <property type="protein sequence ID" value="AQT67299"/>
        <property type="gene ID" value="STSP2_00442"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00442"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="32166" checksum="9E5383F69B5F326F" modified="2017-06-07" version="1">MRHKLGIFSFFGYRLSLTTRVKLIRQAGFEMTGLWWHEFAKGAEPLKDRPRIVRDHGLELDNVHIPYRGAKALWSREKSRRQRYVDYCRECLEDCARHDIGKMVMHLSVGNKYVQPNGHGLDTLRQLAEFAENVGVDIAFENTRHIEMLDAVLDQIDSPAVSFCYDTGHDNVWGEPAGQIAVDWAERMSITHLSDNRGIMDWHSPIGEGNYDWPFLAETLSRCEYAGPLMLEVFTRDRELPPRVFLDNCFHGLRNFAKMVAEQSVYQKQETRTYDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC7</accession>
    <name>A0A1U9NHC7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rplI</name>
        <name evidence="11" type="ORF">STSP2_00475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00475"/>
    <dbReference type="EnsemblBacteria" id="AQT67331">
        <property type="protein sequence ID" value="AQT67331"/>
        <property type="gene ID" value="STSP2_00475"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00475"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="10">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18700" checksum="984580186E76DDC9" modified="2017-06-07" version="1">MKILLTQDVENLGYLGDVVDVKDGYARNYLLPYGIATVPTEGNIKSLADEKAKRAEERRLVREQLERAAEKVEGAEAVIASKANEQGHLFGSVTERDIAENLREQGYEIADDMIKIDHHLKEVGGHDVEVKLAADLSAQIKVTVISLEQAEEAANAPAEEAETEEAETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ1</accession>
    <name>A0A1U9NHJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">pheA</name>
        <name evidence="22" type="ORF">STSP2_00357</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00357"/>
    <dbReference type="EnsemblBacteria" id="AQT67214">
        <property type="protein sequence ID" value="AQT67214"/>
        <property type="gene ID" value="STSP2_00357"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00357"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="87"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="273"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AQT67214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="356" mass="39261" checksum="A53F0C13E466960D" modified="2017-06-07" version="1">MSLEDLRKKIDDIDSKLVELLNERARVVVKVGKYKDKNGGPIYAPHREKAVLEKISRANTGPLPDKTLTAIWREMMSGSFFLERPLRIAFLGPEGSFSHSAAMLKFGQSVDYEAVADIRTIFNEVSKGHSDLGIVPIENSAGGGIDESLDAFVDSDVYICAEVYMAIHHNLLANCKLEDVKEVYSKPEVFAQCRKWLSDTFTGAKTIAVASSARAAQMAAEKPYTAAIGSTAAADLYGLKIVCENIEDVPNNVTRFLIIGKQDTPPTGDDKTSLLFSTAHKAGALVDVLEVFRDHGLNLANIESRPSKKREWEYYFFVDFVGHKSSEQAQKALEAAKKHCLQLSVLGSYPKNDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ1</accession>
    <name>A0A1U9NHQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67130">
        <property type="protein sequence ID" value="AQT67130"/>
        <property type="gene ID" value="STSP2_00271"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00271"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010744782" evidence="1">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21545" checksum="E3CE2648EB519B05" modified="2017-06-07" version="1" precursor="true">MICTRNLLTVVACCVFIVPVCGCWPGADLIGTYEKDISGKQAFWGGYSEGQTYVLLHDIFLKRDPPETYNSKIRMYAGVPPRELTYCVRGLIYSSPDSIEQYRDAPEEWPQIKGIIKAGTKLECTKIIGWGTLMWPMSHTIYATVKDGDYTGKLIDIKDLSLRSRVKIGFDEEYVLHPNPDLLKKENEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI33</accession>
    <name>A0A1U9NI33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67475">
        <property type="protein sequence ID" value="AQT67475"/>
        <property type="gene ID" value="STSP2_00622"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00622"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="38" mass="3984" checksum="F1008E485EB14058" modified="2017-06-07" version="1">MVVAEGAADHFDIGRVAVEVVNAVGAVGAVVFWPDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI35</accession>
    <name>A0A1U9NI35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ORF">STSP2_00750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00750"/>
    <dbReference type="EnsemblBacteria" id="AQT67602">
        <property type="protein sequence ID" value="AQT67602"/>
        <property type="gene ID" value="STSP2_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00750"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="339"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="469"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="580" mass="63870" checksum="82B5650257A0F04A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI73</accession>
    <name>A0A1U9NI73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">purA</name>
        <name evidence="12" type="ORF">STSP2_00769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00769"/>
    <dbReference type="EnsemblBacteria" id="AQT67621">
        <property type="protein sequence ID" value="AQT67621"/>
        <property type="gene ID" value="STSP2_00769"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00769"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
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</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="12">ST-NAGAB-D1</strain>
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        <source>
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</entry>
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            <fullName evidence="4">Trehalose and maltose hydrolases (Possible phosphorylases)</fullName>
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        </lineage>
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    <reference evidence="5" key="1">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="1007"/>
        </location>
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        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111426" checksum="C99FD6817323E390" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ2</accession>
    <name>A0A1U9NIJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin N-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67607">
        <property type="protein sequence ID" value="AQT67607"/>
        <property type="gene ID" value="STSP2_00755"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00755"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15840" checksum="E2316992E5CC195D" modified="2017-06-07" version="1">MTMRSDVVAQVREVYDWLELKLADRKPVCGACGNCCDFAGFDHRLYVTLAELEYFRAAMGPDILEMSEGRCPYQQDSKCSVYDHRFAGCRIFNCRGDENFQSELSEETIRKFKRICRDTGMEYLYMELGAALKLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN3</accession>
    <name>A0A1U9NIN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67789">
        <property type="protein sequence ID" value="AQT67789"/>
        <property type="gene ID" value="STSP2_00938"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00938"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="184" mass="21607" checksum="D73D05484234B8B1" modified="2017-06-07" version="1">MRQIDITAQPQFFSVIKAQMITLWFGWPRRVLGFTPLLVLACFVIYDKYPDARYLAWLIVGALALVWTVILVRYTTAAVKYYRGEELRGRRFEHFYKYINDQGLGIESDEYEIFFRWSAFEYMIETRNFIFLTTKPVRVSIIVFKSLLPPETSAAVIEVISKTQIENKKFHGKPWIKTKSGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT2</accession>
    <name>A0A1U9NIT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroB</name>
        <name evidence="10" type="ORF">STSP2_00845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00845"/>
    <dbReference type="EnsemblBacteria" id="AQT67697">
        <property type="protein sequence ID" value="AQT67697"/>
        <property type="gene ID" value="STSP2_00845"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00845"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39701" checksum="AC028F69F19FE363" modified="2017-06-07" version="1">MTQIKVNIPAKPAQAYTITIGSGQLADLWPELTERYAGKSMFIVTDANLVKAGHLEKLTGTNEVQSCVIDPPGEKSKHIQTVVNIIEAMEKEFMGRDSVIVALGGGTVGDIAGFAAAIFKRGVDVVQIPTTTVAQADSSVGGKTGVDSTLSKNAFGAFWQPTEVCIDVETLKTLDDREYLAGLAESIKHGLIADADYFEFLEQHITELRAKDTATLEQIAERNCRIKAAVVEEDPTEKNKRRILNYGHTIGHAVESASNYELLHGECVGIGMVGAAMIEAKMGIGDKGRVAKIEYILTRLGLPVSIPAELDKDQLIDIIRRDKKAVAGWPKFVLLDQIGTALCKNNQWAHDVPPEIVEQTLTEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ48</accession>
    <name>A0A1U9NJ48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pepA</name>
        <name evidence="10" type="ORF">STSP2_00907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00907"/>
    <dbReference type="EnsemblBacteria" id="AQT67758">
        <property type="protein sequence ID" value="AQT67758"/>
        <property type="gene ID" value="STSP2_00907"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00907"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="507" mass="53184" checksum="8272E141B186D1FE" modified="2017-06-07" version="1">MPKRAIDISVKTRKADPSQIKADILAVGIFSDSKKPAGLAKDIDKQLNGEIGNLLGMEDFTGGFGKTAVLYTNGRITAPRVLLVGLGEKKELASCKLRKAAAHAADKAVNLKARTLALAIHQDLPAKFDLTDVGQTLTEGIYMGGYRYDEFVSKKDSRLNKLNVLLTDADQSAARKLGKGAKAGNIIGQAQSFARTIANRPGNIINPKTLASTARKMASDIPGLTCTVITEKQLKQKKAGGILAVGGGSATKPCMIVLKYSPTGKTKSKRNIALVGKAVTFDAGGISLKPSAGMHDMKFDKGGGMCVLGAMQAISKLKPAATVYGIIPAAENMPSGTSYRPGDIVTTMSGKTVEIQNTDAEGRMILADAIHHATQLKCDTIVDVATLTGACVVALGKHMAGLMSSDDKLIDQLKQAADKSGERVWHLPSGPEYLEQMKSKIADLKNTGGKGGGACTAAAFLKEFAGDAKWAHIDIAGVEIFTDGSKIGSPGSPGFGVRLLTEYVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB7</accession>
    <name>A0A1U9NJB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan endo-1,3-beta-glucosidase A1</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glcA_1</name>
        <name evidence="3" type="ORF">STSP2_00989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00989"/>
    <dbReference type="EnsemblBacteria" id="AQT67838">
        <property type="protein sequence ID" value="AQT67838"/>
        <property type="gene ID" value="STSP2_00989"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00989"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211446" evidence="1">
        <location>
            <begin position="23"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="275"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="56914" checksum="41C7A245A252FA83" modified="2017-06-07" version="1" precursor="true">MKNTLFIAAILALTCLSTARSAENTLIAHWTFDQTDYAKGLYLDVSGNDHHAAANTPPPNFVPGVNGNTTGALDLYANPAAWATAGTFDPGQTLTISAWVKLNPNASGDTCITAKRSDSAHWDDAKWEFLVQADTAGIWANLSTNLAAPGILDPPGQWQHLCLTIDANGTATLYKNAVKMRTFEDRAPGPDDSGTVAIGARANGTIPLHGTLDDVRIYNYPLPYEQIAQLYVDQAGGEICADRPSMDFNNDCIVDYSDLMIFASHWLEDGYGPLTDDGSLPYLPPDKTWTLVFNDEFEGTDIDLTKWTIQGDWQRKGGWWTKDNSYLDGQGNLILRVRKDGDRYTSGAVWTKDKFEHKYGYWEARCKLPHQPGHWSAFWIQCAGTGSIGNEGTDGTEIDVMEWPYRDGRVQHALHWDGYGEEHQSVGQITNYPAALEGWHRFGVWWTPTEYIFYIDGNEVWRTSAGGVSQVPEYVYLSEEIGSWAGDITQANLPDYFTVDYVRVYDVTDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL5</accession>
    <name>A0A1U9NJL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67997">
        <property type="protein sequence ID" value="AQT67997"/>
        <property type="gene ID" value="STSP2_01151"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01151"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="363" mass="40967" checksum="01EF578047796491" modified="2017-06-07" version="1">MKRYITGMDSNALSKRDNIVRAIRFDRPEYIPMTFHINEACWGHYPAEFLEELMAEHSFLFPAAKRKQARPELEQQVPERVGRPHVDPWGCKWETAMDGIVGTVTEHPLADWGAFESFIMPDPAVTDGKVGVDWGEISSSIEKAKAAGEFTVGGLIHGHTFQRMVDLRGYEDLLFDMFDGHADLQRLIEMVERFNAEIVQRYVDLGVDMMCYAEDLGMQSGPMVSPEMFKKYIGPVYERLMEPAREAGCIIHMHSDGCVRELVDELVRDGVEAVNIQDLVNGIDWIRDNLGGRVCVDLDIDRQEVTVHGSPGDIEKLIREEVTKLGSPQGGLMLIYGLYPGVPRENVRALADAMEKYAFHFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN0</accession>
    <name>A0A1U9NJN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68132">
        <property type="protein sequence ID" value="AQT68132"/>
        <property type="gene ID" value="STSP2_01287"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01287"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010699963" evidence="2">
        <location>
            <begin position="24"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="52679" checksum="BED84C72EA0F589A" modified="2017-06-07" version="1" precursor="true">MKRNILIFLLTAAALLTGCSSNSTDPAPAFQDVRGVIKQRTTYDVSWDTVNPAGQKIQQQIDTMLDHELISAHAVQIALLNNPRIQAVYEELGIAQAELVQAGLFKNPVFDFSIRFFEGSNDDDIVEMSLVQNFMDILLTPLRVDMEQAQLQITKAHVTLKVFELVAQTHKAFYSYQSAAQINAMYEDILFSTEAAYEAAQRLHDAGNITDLELARHRQLYEQTKLNVADSQNALLQARETLNAKMGLWGERAAKWTARPKLPGIPENDLPTDNIESLAINNSLNLGVIQKQIEAVAARMDIEVTEKMFAEFRTGISSERESDGTWTTGPAFATGIPIFDLGQAAEARGAAKIRQLLDNYTAAAIDLRAAGRSAVYRLKNAKRQASYYKKILVPLSEQITLETHLQYNAMQVGLFHLLDAKRDEIQTQLRYTTSLRNYWIARTQVELLLNGYMTEPAAQTMTPDPAQAMGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJT0</accession>
    <name>A0A1U9NJT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67766">
        <property type="protein sequence ID" value="AQT67766"/>
        <property type="gene ID" value="STSP2_00915"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00915"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323973" evidence="1">
        <location>
            <begin position="22"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="39056" checksum="D32C00472941CE7F" modified="2017-06-07" version="1" precursor="true">MNKFLTLVFCFVMPLASCSEASDNYRIEGYSKDVKAVTKAMLDVQDLGVFSEEGLLGAAEFVFSCVGSTSFEEERMLEKLDVFLNEWDSRAAGKEVLPYHAKRAALIRFMASLDDNAKAKQTPTDLLELCPDNGFVWMIAAEDAWRKGEWTECKNSCEKAFNSETVTTYARGFKARIHTAVQEMGLLGDRTAKFSAFQRTSPVEMDFLIRHLCLLNNLKFIQDFAYSVEELESPELAARKYLSLLSDSLPVGSLGIGNALHKKLLMDCTTALCQKEKELVEEEYQLIKLRIKVRKMLINGGNPEALKAYLDDDIDAYVQDVTGQPTQRLNWKQFWERNWPTKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU8</accession>
    <name>A0A1U9NJU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68189">
        <property type="protein sequence ID" value="AQT68189"/>
        <property type="gene ID" value="STSP2_01344"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01344"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29777" checksum="6C9B367703309044" modified="2017-06-07" version="1">MKKRKTQRAGFTLIELLVVIAIIALLLSIMMPALSMVKKRAKLVVCGSNQKQLLTGVLSYATENEGKFPPKIHTNDSWPSYLNYKWGAGVDQGRYMYEYLGSYLPTVDVYICPLGPNPDGYDLQERYADYREPGVIPNYPSGGGTVVSSNFLWGGFSFSGATGSETGRTFVGPKRQSSKSAKLLVSDVFTEWVGGEWLTAHQGDLNAAKGPVEDRHYGNNLSALWLVEGVDEGSIDLTMNAGYIDGHVERFDADETEAFGWQRIPQDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK45</accession>
    <name>A0A1U9NK45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-iminoacetate synthase</fullName>
            <ecNumber evidence="6">4.1.99.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiH_3</name>
        <name evidence="6" type="ORF">STSP2_01437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.99.19" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01437"/>
    <dbReference type="EnsemblBacteria" id="AQT68279">
        <property type="protein sequence ID" value="AQT68279"/>
        <property type="gene ID" value="STSP2_01437"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01437"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036355">
        <property type="term" value="F:2-iminoacetate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024021">
        <property type="entry name" value="FeFe-hyd_HydE_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034422">
        <property type="entry name" value="HydE/PylB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43726">
        <property type="entry name" value="PTHR43726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00348">
        <property type="entry name" value="FeFe_hydrogenase_maturase_(Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03956">
        <property type="entry name" value="rSAM_HydE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="350" mass="39478" checksum="180949442A09F9C3" modified="2017-06-07" version="1">MSDVRAVLNRVYTADMPDLRDIEYLLSLEDADQIDELYKFADNVRREQVGDGVLLRGIVEFSNYCRNTCAYCGLNKYNKQIRRYRMAHDEIMACLDKIVSCNTKTVVLQSGEEDELDAAWLQDLLFKIKDKHDIAVTLSLGERSDQEFEMWRNAGADRYLLKIETSDKQLYEKLHPEMSFDRRVECLRKLGSMGYQLGSGCMVGLKGQTTASLARDVQFFVREKIAMIGIGPFIPHSQTECANHACGDVELVCKMTAVTRIATKNTHMPATTALGSLGNGDMRLKALACGANVLMPNFTPVEYKKLYEIYPGKRCVNEPTGACSGCMEKMVKSIGRYVDWARGDTLKSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK52</accession>
    <name>A0A1U9NK52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01269"/>
    <dbReference type="EnsemblBacteria" id="AQT68114">
        <property type="protein sequence ID" value="AQT68114"/>
        <property type="gene ID" value="STSP2_01269"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01269"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="166"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="251" mass="28198" checksum="F5F2CBC7CB68745B" modified="2017-06-07" version="1">MAGCFSDRMIFIPPPSSYTDSDQVIKIPVGEHESKSDNENISAFHLPNGKAEYTILYSHGNAEDIGHNDYLLARFRDHGYSVFAYDYRGYGTSEGKPSTKHAYEDADAAFKYLTGELGTDPGKVIVYGRSVGAGLATYLAEKHDVGALVIQSGFVTAFRVITHYPILPFDKFKNIDRIKNINCPVFITHGQKDKIVKPWHGKKLYEAANDPKLKLWVPNTGHNEDLIHIAGERFWDKMDELEKAINQNQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK83</accession>
    <name>A0A1U9NK83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pimB_1</name>
        <name evidence="4" type="ORF">STSP2_01491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68332">
        <property type="protein sequence ID" value="AQT68332"/>
        <property type="gene ID" value="STSP2_01491"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01491"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="228"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="417" mass="46949" checksum="C49433415CAC06A8" modified="2017-06-07" version="1">MSKNNSKRILFLTHYFPPESNAPASRVYEMTKRWVAAGHDVTVLTCAPNVPNGIVYEGYKNKFRQTELIDGINVIRVWSYMAANKGTLRRTLNYLTYMLSAIFWGLFVKKPDVIIATSPQFFCGWAGVWLKRLRRVPFILEIRDIWPETVVAIGAIKNRNLLRLFEWLEIKMYKASDIIVTVGEGYRQKLLERNVSSKKIVIVSNGADLNFFKPSDPDSQLLESIGIKDKFICSFIGTVGMCSGLKVIVDAAKLLSQKGYSELVFLVVGDGAVRQELQAESEKLKLSNIVFTGRRPKIEMPKFIASSDVCLAHLQKKDLFKTVIPSKIFEAAAMAKPIVLGVEGFAAKLLNEAKAGICIEPENYVELADALILLYEDPNRKTQYGQSGYSYVLKNFNRDKLAKDYLNTIECLVGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK90</accession>
    <name>A0A1U9NK90_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">acpS</name>
        <name evidence="10" type="ORF">STSP2_01309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01309"/>
    <dbReference type="EnsemblBacteria" id="AQT68154">
        <property type="protein sequence ID" value="AQT68154"/>
        <property type="gene ID" value="STSP2_01309"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01309"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14134" checksum="66433BDCBF6C157D" modified="2017-06-07" version="1">MKIVAHGIDLVELGRIAEVLERHGERFLDRVFTQREQADAAGVKRRVEKLAGRFAAKEAVLKLIGTGWRGKIAWTDIEVVNGEMGEPVVNVSGEVKRIADEMGVEQMTLSITHTAELAMASVVALRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK93</accession>
    <name>A0A1U9NK93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67936">
        <property type="protein sequence ID" value="AQT67936"/>
        <property type="gene ID" value="STSP2_01088"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01088"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12257" checksum="575DF57ACF29EE49" modified="2017-06-07" version="1">MFAKESNFPISKEIFAGTKFFFAFFANLPVCRVRNKCEINFERWRMSDSLEQNLEQNAQGPKKVRGDAGEVEQHGLTDQIAVDRYLASKKAARSKGLGIQMSKMVPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB5</accession>
    <name>A0A1U9NKB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68361">
        <property type="protein sequence ID" value="AQT68361"/>
        <property type="gene ID" value="STSP2_01521"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01521"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31027" checksum="A8178C283BE6CBDA" modified="2017-06-07" version="1">MLDFLTSLIAWLVMTADSIGSVLFGWIAIVPGWLSNTIIASITGVLMLLVFKYTSNQDAIGRVRDRIKANMLALKLYKDSLYVTFKSLGGLFAGAGSLLLHALRPMGVMIVPMVLLLGQLALWYEHRPLAIGEEAIVSVQVQETQARPSVRLIEAEGVEVVVDRSWFEKKNAYYWKVRATEPGEYDMLFDVDGFDVEKKLVVGEGLAKVNVKRAGWDMSDMLMFPGEISFAESSVVQGISIEYPQREGIAGGAFWWMVWFFGVSMIAALIFKPVFGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC5</accession>
    <name>A0A1U9NKC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Teichuronic acid biosynthesis protein TuaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tuaB</name>
        <name evidence="8" type="ORF">STSP2_01531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68371">
        <property type="protein sequence ID" value="AQT68371"/>
        <property type="gene ID" value="STSP2_01531"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01531"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="503" mass="55918" checksum="B7125173C9FF556A" modified="2017-06-07" version="1">MQNKEPKPQKEHHDLFKKSAKGVFWKTVLKISTELLFAVRLVIFTHFLTTEQMGVAVVGWLVMGGLEIFTKTGFQSAIVQRHGDIEGYLDTVWTIEAARSVLLYLLAFLAAPYAAVFLSDPSVADLAVKVIRVSAICLIFRGFSNAAVIKYTRELQFNKLFHIEMWGRLLGILVGVVLVCVYKSVWGVVAGRVAEEFSRFLLSHILTKRRPTFALVFSKASELWKFGRHISVGILLTFLLTQGDDYFVAAFLGPAALGLYQVAYKISNLPSTEITRVVGQVAFPAYSKIQNDIPRLRDAYLKVFTLISFISVPVSVLIFLFSESVVKVAFDEDWQAIAPLIKVLVVFGFARSLGASRGPLYVAVGKPNIAARLQMLNLIVLAAVIYPLARTYDVLGVALSLALMQTVAQPVGFWMVARITQSKLVDCLKPLLIPVIASAGMLFSVVLIRLLPFEPSQIWFLALQVMSACGTYCFLAYLIDKKSRRPALTAIARQLMDIRAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI1</accession>
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        </submittedName>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
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    </feature>
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            <dbReference type="EMBL" id="AQT68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18093" checksum="C158556500B18CA0" modified="2017-06-07" version="1">MLYVYVFLLVILNAFWLMFTFLALPGNWLVVLSTWGFAWWTWEERVFSVATLVVITVLAVIGEIIEFFAGMGGAKKAGASWLGAVGAIIGMVFGAVFGTVLLGVPFVGTLAGACVGAGIGAWGLEMMRGKEFEESFRFGLGAGIGTLIGTGSKFVLGVVIWIIVAVAGFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ8</accession>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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        </source>
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            <dbReference type="EMBL" id="AQT68429.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="246" mass="24415" checksum="F07E751255000CA8" modified="2017-06-07" version="1">MDTVLAGTLVSLIAGCAMGVGGAFVYVVRRPSDRTLDTLRGFGAGVMLAAVCFGLTVPAVDLGGIRPVIAGIAAGAALVMFAERAVAHMHFGGREVLVAGRTVFLAAAGAVIRSLSAGVAVGAAFGRQGALEAGWPIAIGIGAANIAEGLPIVFVLVGEECKRGRAIGIVLCAGGAAGVGGLVSVSVVSFVPWLLPAGLAFAAGAMLYVVFEEIVPETYAGGSARPATMGLVAGFMLMLMLESVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP4</accession>
    <name>A0A1U9NKP4_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">atsA_15</name>
        <name evidence="6" type="ORF">STSP2_01677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT68512">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF4994"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16385">
        <property type="entry name" value="DUF4994"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
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        <location>
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            <end position="384"/>
        </location>
    </feature>
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        <location>
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            <end position="486"/>
        </location>
    </feature>
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        <location>
            <position position="89"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="531" mass="58548" checksum="D2F953061E3D0E5A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR5</accession>
    <name>A0A1U9NKR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68180">
        <property type="protein sequence ID" value="AQT68180"/>
        <property type="gene ID" value="STSP2_01335"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01335"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034756">
        <property type="entry name" value="T2SSM_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10741">
        <property type="entry name" value="T2SSM_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20990" checksum="D81CB092CB8190E3" modified="2017-06-07" version="1">MAVTITERDKRTLKIGGIAVAAILLYFLVLEPWFVGWGSVRTQLAERQEEIELTGQGGGQAKLLGVMKVVPAFEMPAKAPEQKVLFRDKFAEQLQRARINYKSFKIFEPAKTDSFASHKTIKMQVQATCKYPQVIDVLAALRENPYFAAVDELKIKQQDRKKRLIDIDLTVTTLCETNNENENTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU3</accession>
    <name>A0A1U9NKU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">murJ</name>
        <name evidence="10" type="ORF">STSP2_01718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01718"/>
    <dbReference type="EnsemblBacteria" id="AQT68551">
        <property type="protein sequence ID" value="AQT68551"/>
        <property type="gene ID" value="STSP2_01718"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01718"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="528" mass="57571" checksum="8DA5E33EBB3101C4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU6</accession>
    <name>A0A1U9NKU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68136">
        <property type="protein sequence ID" value="AQT68136"/>
        <property type="gene ID" value="STSP2_01291"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01291"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="285" mass="32479" checksum="F2EB7DD16F97C53F" modified="2017-06-07" version="1">MKNLIILTMLTAALIIGCEDRSQDQLIDQMTEEAQQADIPVTREQIEQMAKASRENGTEPLCDFTPFLAALKNNDPQNAFTFLSDDLKTLWPENKFTADITQLRQQIGSDWQPSLMEFMNYPQNDLPVCTAQYQLTSDFQYTIKMMALPADSDSDLQILHVNLIRPYAGPDAPAFRDTAAKFLSAVDELDLKKARQLMADQYKDQLQLSNLQSFKDALYSETEKQKQYEKILGPIQITTSDGRTFFRILADSQIHPFMKLEILMQKPADQINIAGLKLKGRIKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ4</accession>
    <name>A0A1U9NKZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68398">
        <property type="protein sequence ID" value="AQT68398"/>
        <property type="gene ID" value="STSP2_01558"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01558"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47213" checksum="2413EF3A1AFD5D3B" modified="2017-06-07" version="1">MIKNIFRITKFAFITGGILLTFFIFIELIRAYQTLRDMHPIAGYVYLAILAGSLAYVIIYVARTLKNHPPSLKRPKIKDTSNASPRRLRKYARYLNRYIARLATSPALDEHQQEVAQTGRTTLTEHVNSASDTECILTAIRRAEESTVNPLLEIIDDYAARHVRNCMRDVMIAVTLSPYKAADLIIVLYRNLMMVTGIIKAYNSRPRLREQLSIMVDVLAIVATVNYINMGKNLIEGLASRVPGIGKFVDDIAQGMGAGFMTTVCGHAAMQRCRAFTGWDAEAAKRNIFNNITDFYADVKNVFWKDIWPALRVRAGEVSTDMKDKIAATLDDTQAAVSKIVKSPFTAAYTATSSAVNVSTNGTKVVVNSAGKVVTTAGNVTYKTARSVVKTPGKLFRFGKKTATSAASSLRRKPKKLPPETDNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL68</accession>
    <name>A0A1U9NL68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68478">
        <property type="protein sequence ID" value="AQT68478"/>
        <property type="gene ID" value="STSP2_01642"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01642"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13084" checksum="95F56FD8AE3EFE62" modified="2017-06-07" version="1">MADKNRKKLLKKQAKYDKKASKAALKRQKKSGESGDISEVNPGRQSLGSRLVTFAQGVRGVLFLILAISIMIAVVLADKGYIVNLEDIFDSIVAIKAGKAVLAIIAVAFFVLGLKNLRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL99</accession>
    <name>A0A1U9NL99_9BACT</name>
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        <submittedName>
            <fullName evidence="10">Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB</fullName>
            <ecNumber evidence="10">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mtaB</name>
        <name evidence="10" type="ORF">STSP2_01773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01773"/>
    <dbReference type="EnsemblBacteria" id="AQT68605">
        <property type="protein sequence ID" value="AQT68605"/>
        <property type="gene ID" value="STSP2_01773"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01773"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="166"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="463" mass="52188" checksum="0989BD06783F162D" modified="2017-06-07" version="1">MRTFAIKTLGCKVNQYESQQVRELLESHGLEQTSAETAPDLVVINTCCVTHVASAKSRQLTRKTKKTNPHSVVVVAGCLPAGQTEELKGLEKQAIIVEQKDLLVQTLKSLLANSTEASNRTTTGSRTLKSAKIKHKNDSKNAETPTPNKSTSHETNDSELPDLKSYKGQTRAFLKIQDGCDGFCTYCIIPKIRNKISSKPSETILQEARDLVYAGHKEIVLTGIFLGAYGQETVRRRKWEKESTGKLPELLDKIAQIQGLERLRLSSLEPGDVTEELLEVMCKHDNITHHLHLPLQSGSGRVLKRMCRQYNEKEFIAAIDLLCDRLDRPAITTDIIVGFPGETDSDFQATLNMAEYARFAKIHVFSFSERQNTPAVKMRPKIASDKIKYRSQELRELDSKLQLQFRQQFAGTEMRMIVENAQKQTGRTDRYFEVQIKDNRKYETGELVTGFLSKDAQSLQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD7</accession>
    <name>A0A1U9NLD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane biogenesis protein BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68548">
        <property type="protein sequence ID" value="AQT68548"/>
        <property type="gene ID" value="STSP2_01715"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01715"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911333" evidence="1">
        <location>
            <begin position="18"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="55015" checksum="54F7E1D507B03C2D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH1</accession>
    <name>A0A1U9NLH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68783">
        <property type="protein sequence ID" value="AQT68783"/>
        <property type="gene ID" value="STSP2_01956"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01956"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="385" mass="46007" checksum="71404C48083D0CCD" modified="2017-06-07" version="1">MEKKKIIKRAQVLYLEMVKILGSENEEDMIERCENLLDELEDAWDSFVELGEELRVQLTDECDYFSLLFEETSKRYDLPDCSSTFFMIVVKGDDYLFPQLSKFRQIACTGLDSKSNTQFVCLTEEARIFTELYKNLSEYIQIEDSQRYHYYKHQRHLIDQLIRFWPILCVIAQESGIFLKKYKDNLSTLFEGLIYRRQTFRDLLFDKLSYHTTPEDPYMSELKTPTNSDIQKAIEELAEEQERLLEELRLLMALIDPSIAEEFPLSYLQTFNVDKSAALSSEPWEKYFITSKEMKDLHPRSKFNRSKLQKLQENACKSDGLIMVKYGEKRHADETWEAYNFRHSRQNTLFKCKKQLFFPRQWWKKMYGLHKESLYRKGNGNSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK1</accession>
    <name>A0A1U9NLK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nodulation protein NolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nolA</name>
        <name evidence="2" type="ORF">STSP2_01786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01786"/>
    <dbReference type="EnsemblBacteria" id="AQT68618">
        <property type="protein sequence ID" value="AQT68618"/>
        <property type="gene ID" value="STSP2_01786"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01786"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9348" checksum="B2DC9A3CE3756121" modified="2017-06-07" version="1">MTNKNDLVQIGKAAEQAGVSRQSLQYYLMVGVVEPTEVTDTGRRLFDGDAIEKIKLVRKLNESGYPLRAIRDLFMQGKFGQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN2</accession>
    <name>A0A1U9NLN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">metK_1</name>
        <name evidence="11" type="synonym">metK</name>
        <name evidence="17" type="ORF">STSP2_01995</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01995"/>
    <dbReference type="EnsemblBacteria" id="AQT68819">
        <property type="protein sequence ID" value="AQT68819"/>
        <property type="gene ID" value="STSP2_01995"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01995"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="122"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="240"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AQT68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="399" mass="43740" checksum="C0E0A0BB116BB691" modified="2017-06-07" version="1">MSKINVDHVFTSESVSEGHPDKVCDQISDAVLDACLAKDPASRVACETMVAHDLVANSGEITCSGWEDIDTEKIAREVVKKIGYDHEDLKFWHDSFEYISRLHGQSPDISQGVSEGEGLFKDQGAGDQGMMFGYAANENPELMPTPIALSHRLLLELESIRKNKKLDYLRPDSKSQVSVKYTDGKPDYITCVVISHQTDDVPLDKVRRDLVEIAKEVLEPTGLLRNETEYFVNPTGKFCLGGPYADAGLTGRKIIVDTYGGVGSHGGGAFSGKDPSKVDRSAAYYSRYAAKNIVAAGLAEKCEIQVAYAIGVARPLSINVDTYGTGKVEDSQLQSVLESGSIFDFRPAAIVQELNLLKPDGWSYAQSAKYGHFGRDIFPWEKTDKAEDLKNAVKEMVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV5</accession>
    <name>A0A1U9NLV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xcpT_9</name>
        <name evidence="3" type="ORF">STSP2_02109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68932">
        <property type="protein sequence ID" value="AQT68932"/>
        <property type="gene ID" value="STSP2_02109"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02109"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="297" mass="33029" checksum="909D66E648F03145" modified="2017-06-07" version="1">MQVVRKAFTLIELLVVIAIIALLLAIMMPALQTVKESARVVVCKTNLHQYGLAMELYTLDNDGYFPFVYNWLYSQPNLTKISQGQYLQSDGSYEPGPPCPPQCVWHNERAHPDGGLWPYLKNEDIHRCASFEGYAKQDGAGHHPGHEPAIPMNPQYSYSMNYWLGVESYKWNPNDTSMPPPAGAPGSPEANGRSLRASNVKRPGSVLAFAEENAWTIDGISNFGLDDNSLYILKSMPVNFLATFHKSGGDLETGKSNGVFLDGHAETMDFGDMIADDSLDRRDILEEVFELVWPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ1</accession>
    <name>A0A1U9NLZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannosylglycerate hydrolase</fullName>
            <ecNumber evidence="7">3.2.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mngB_2</name>
        <name evidence="7" type="ORF">STSP2_01926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.2.1.170" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01926"/>
    <dbReference type="EnsemblBacteria" id="AQT68754">
        <property type="protein sequence ID" value="AQT68754"/>
        <property type="gene ID" value="STSP2_01926"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01926"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1496" mass="166496" checksum="CFC3D10AC1DE2E52" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ2</accession>
    <name>A0A1U9NLZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rex_3</name>
        <name evidence="6" type="synonym">rex</name>
        <name evidence="8" type="ORF">STSP2_02150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02150"/>
    <dbReference type="EnsemblBacteria" id="AQT68972">
        <property type="protein sequence ID" value="AQT68972"/>
        <property type="gene ID" value="STSP2_02150"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02150"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23425" checksum="B562B76D515B4802" modified="2017-06-07" version="1">MSQDKPVSVSHPTIRRLPAYLNILRKAQDENKTHISSTFIADKLGYEPIQVRKDLAGLGITGQAGVGFDAAELIDAILGFLGWDNATDAYLIGAGNLGSALAGYKGFKDYNLNILACFDSDLRKVGTEIHGKKVFGMERLAELIERTGVNIAILTLPDKAAQEITDKIVEAGIRAIWNFTTVKLDVPDGVIVERVDLAASLALLSRRTAEAMKNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLZ4</accession>
    <name>A0A1U9NLZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional protein HldE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">D-beta-D-heptose 7-phosphate kinase</fullName>
                <ecNumber evidence="9">2.7.1.167</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">D-beta-D-heptose 7-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">D-beta-D-heptose 1-phosphate adenylyltransferase</fullName>
                <ecNumber evidence="9">2.7.7.70</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">hldE_2</name>
        <name evidence="9" type="synonym">hldE</name>
        <name evidence="12" type="ORF">STSP2_02128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 9">Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.</text>
    </comment>
    <comment type="function">
        <text evidence="2 9">Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.167"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.167" evidence="9"/>
    <dbReference type="EC" id="2.7.7.70" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02128"/>
    <dbReference type="EnsemblBacteria" id="AQT68951">
        <property type="protein sequence ID" value="AQT68951"/>
        <property type="gene ID" value="STSP2_02128"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02128"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01603">
        <property type="entry name" value="HldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023030">
        <property type="entry name" value="Bifunc_HldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="10">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="11">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribokinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylyltransferase" evidence="9">
        <location>
            <begin position="360"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="53818" checksum="46B3888512CCB755" modified="2017-06-07" version="1">MYKKLIKAVTNLGTPRVLLVGDFILDSYIYGDALRISPEAPVPVLKVVDREHSCGGAASVAADLAVLGAKTTCLGVVGKDSNGKLLKDLLEKQGADPAGLIEATDRPTINKLRMVGLAQHRHRQQLLRVDEENTEPLTRADSQRLLEVFESRLAEADVVCLQDYRKGVLSEQFCRKAIELARKAGKRVLVDPPMDKNYDKFKGASAMTPNRYEASAAVGFDINTIDDAARAAQMLTSKLDLEAVVITLDKEGAYLRSPVHTGHIPTVPRTVYDVTGAGDMVLAMLAASLAGGCDYETAVHLSNIAGGIEVEKFGVATVSIDEIVNEIIANNKHKTGKIHTVESLQKELSFHRHQGESIVFTNGCFDVIHRGHIEYLGFCKQQGDILVVGLNSDRSVRELKGPERPINNQHDRAAVLAGLASVDYITIFDEPDPLALIKQVGPDILVKGEDWAEKGVVGREFVESNGGKVVLAPLVDGKSSTSTINKMKELDGNDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM16</accession>
    <name>A0A1U9NM16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01940"/>
    <dbReference type="EnsemblBacteria" id="AQT68768">
        <property type="protein sequence ID" value="AQT68768"/>
        <property type="gene ID" value="STSP2_01940"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01940"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_38N" evidence="1">
        <location>
            <begin position="246"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38C" evidence="2">
        <location>
            <begin position="720"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123669" checksum="48765E2D45F87181" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM45</accession>
    <name>A0A1U9NM45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rtcB</name>
        <name evidence="5" type="ORF">STSP2_01744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01744"/>
    <dbReference type="EnsemblBacteria" id="AQT68576">
        <property type="protein sequence ID" value="AQT68576"/>
        <property type="gene ID" value="STSP2_01744"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01744"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="324"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="476" mass="51068" checksum="AB571CD69B5CB97B" modified="2017-06-07" version="1">MDTNRLTRISKNEWRIEPHGKMNVPGIIYATAELIEAMDDKVFDQVRNVAQLPGIVQASYAMPDAHWGYGFCIGGVAAFDPDKGGVVSAGGVGFDIACGVRTLHTNLTAEDIASVRKELAEALFRHIPAGVGSTGKVKLSMHSIDDVLTGGAKWAVEHGYGLTDDLRFIEENGCMPDADQSKVSDHAKKRQLEQVGTLGSGNHYLEVQVVDKIYDPKTAKAFGIHEGDVKISIHCGSRGLGHQIGTDYLKSMATAANSMGIDLPERELACARLDSPIGLDYLGAMAAGVNCAMANRQVITHLVRQAVEKVLPKANIRLLYDVSHNTCKREKHTIQDGKKSLYVHRKGATRAFGPGDPSLPREYKDLGQPVLIGGTMGTASHILVGTEKSRELSFGSACHGAGRTMSRRSATKRWQGKSVVNQLAGEGVLIRSKSLRGVAEEAPGAYKDVDAVVESAQNAGLANRVARLVPVICVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM72</accession>
    <name>A0A1U9NM72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01774"/>
    <dbReference type="EnsemblBacteria" id="AQT68606">
        <property type="protein sequence ID" value="AQT68606"/>
        <property type="gene ID" value="STSP2_01774"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01774"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="783" mass="87604" checksum="313DE5C3D7EE129C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA6</accession>
    <name>A0A1U9NMA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02268"/>
    <dbReference type="EnsemblBacteria" id="AQT69082">
        <property type="protein sequence ID" value="AQT69082"/>
        <property type="gene ID" value="STSP2_02268"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02268"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="273" mass="30847" checksum="64A6B58D70ABFA04" modified="2017-06-07" version="1">MRRPRKDNAFTLIELLVVISIIALLLAIMMPALGMVKEKARSLVCRTNVRQMTLAMAMYAEDNKGSSVPMIHSVGEYWFHQIAPYLGDNDYKDNPEKNIEGSMEVTFCPSTKRPSSADAYWFGGLNKSWKYLGGEGSYGMNLWLQSGKSGSFGTNPPLSNYPGNWFKKYSTVRGSVPVFSDSVWVGSWPFEQYEPVNDFMGSGYGTPNSPSFPDMETAYMARFLIDRHNMAVNVGFTDTSVGTLKLDEMWSVKWHQNFRTTKSIDLTKPYRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC0</accession>
    <name>A0A1U9NMC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="2">3.2.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagA_2</name>
        <name evidence="2" type="ORF">STSP2_01912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.49" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68740">
        <property type="protein sequence ID" value="AQT68740"/>
        <property type="gene ID" value="STSP2_01912"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01912"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008456">
        <property type="term" value="F:alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="48642" checksum="16537A78DCCF4B69" modified="2017-06-07" version="1" precursor="true">MVRFDRRSFIKANAGLVAGLSIPGLAGSAFGAEHEGDMPLRIGAVGTGNRCRYLMSVVLGLGGVEMPAVCDIDPKALAAAKKVVTNAGQPEPKGYSGPTDYKKLMDRDDLDAVIIGSPWDLHTPMSVYAMKAGKAVGCEVPIAYTMEECWELIETWEKTGTPCMQLENWSFRSDNLAILNMIREGLFGTITHAHCAYSHDCIDHWYFERGTGDSRWGAKFLVEHNRAQYPTHQQGPVLSWMDIGCGDWYDTITSTATDQFAIHDYFKRNFPDHPNAKRKYKQGDIVTTVVKTKKGKTIVINFDMQSPRPYDNRWMVQGTRGIYNEQRNALYVTGKSPQYHSWEPFPPYHNKYKHEWAKNAFGGHDGADGIMLTQFIKSLRENKPLPLHLYDGVLMAASGPLSEMSIEKNNQPIEVPDFTRGKWKTRKPYFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC7</accession>
    <name>A0A1U9NMC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01062</name>
        <name evidence="4" type="ORF">STSP2_01825</name>
        <name evidence="5" type="ORF">STSP2_02024</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67910">
        <property type="protein sequence ID" value="AQT67910"/>
        <property type="gene ID" value="STSP2_01062"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68656">
        <property type="protein sequence ID" value="AQT68656"/>
        <property type="gene ID" value="STSP2_01825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68848">
        <property type="protein sequence ID" value="AQT68848"/>
        <property type="gene ID" value="STSP2_02024"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01062"/>
    <dbReference type="KEGG" id="alus:STSP2_01825"/>
    <dbReference type="KEGG" id="alus:STSP2_02024"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23769" checksum="2AE4678BE9D41A45" modified="2017-06-07" version="1">MHHRRKGRKSKGNSDNSCSVQKAEYKDHVWTYDFVSDQSEDGRSLKFLTVLDEFTRESLTIEVGRSIKSGDVVETLEYLFAVRGVPGFIRSDNGPEFVAHAIKKTLGKKNVETLYIEKGQPWENGFIESFNGKFRDEVLNRELFYSVKEAKVIVEQWRMEYNNHRPHSGLDYATPAEFAASCIASASPTAQLQQYTTDEKDNSLTEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML3</accession>
    <name>A0A1U9NML3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69149">
        <property type="protein sequence ID" value="AQT69149"/>
        <property type="gene ID" value="STSP2_02336"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02336"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="534" mass="60066" checksum="946E8ED3D9DF6A79" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN7</accession>
    <name>A0A1U9NMN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01976</name>
        <name evidence="9" type="ORF">STSP2_02282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68803">
        <property type="protein sequence ID" value="AQT68803"/>
        <property type="gene ID" value="STSP2_01976"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69095">
        <property type="protein sequence ID" value="AQT69095"/>
        <property type="gene ID" value="STSP2_02282"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01976"/>
    <dbReference type="KEGG" id="alus:STSP2_02282"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="137"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="39362" checksum="A9C42C73CEBD20EA" modified="2017-06-07" version="1">MMQAGLFDWQTRFEQLDNSGDPLVKLNEIVDWEQFRKTLEVVRDKKRKSNAGRKPFDVILMFKILILDSLYNISDDQLEFQIRDRISFMRFLGLGIGDRVPDAKTIWLFREQLTEAGLVENLFTQFDEFLRKNGFSAKKGQIVDASIVAVPKQRNTRDENKSIKNGEVPENWSDTKKRQKDTDARWVQKNGVNYYGYKNHIDIDVKHKFIRSCEVTPASVHDSNVFEDLLDANNSSKDVWADSAYGSTEKRDNIKEEGYRGQIQRKGCRYKKLTQRQIEANYKRSKTRSRVEHVFGIQKMRAGNLIIRTIGIARAKTKICMRNLAYNIDRYCLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMN8</accession>
    <name>A0A1U9NMN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02356"/>
    <dbReference type="EnsemblBacteria" id="AQT69169">
        <property type="protein sequence ID" value="AQT69169"/>
        <property type="gene ID" value="STSP2_02356"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02356"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8866" checksum="E2496C0F9F2AC4B3" modified="2017-06-07" version="1">MTLVQLCKPEYAADILTTDRHTSCFMPCTMSVWEDDSGKVYLSKINLGLMGKMFGGNIAKVMGGQVVKDEHEILKGLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ7</accession>
    <name>A0A1U9NMQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02302"/>
    <dbReference type="EnsemblBacteria" id="AQT69115">
        <property type="protein sequence ID" value="AQT69115"/>
        <property type="gene ID" value="STSP2_02302"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02302"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504947" evidence="1">
        <location>
            <begin position="26"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="373" mass="43037" checksum="F661AC3CAAA1B000" modified="2017-06-07" version="1" precursor="true">MMRNCTTTIMVILIAGTTACCTAGADSKFARWGRQTLEVIERDHRIEGQSGYYEDQSREDVSFTWGNAILLLAYAEAAKVDPAYEEPLENLHKHIQAYWVVDKGIGGYDALPEPREKVDRYYDDNAWIAMAQIDAYHATGKDKYLQAARRSIQFSLSGMDTESGGIWWRETWERPRRKSKNTCSVAPTAFACLRFYEVTKEKSYLENAKDLLIWLDENLKDEDNIYFDSVRPSGRIGRRKWSYNSAMPMRCYIVLHKLTGENKYLEKAVEIAVAAHKRWFDSSTNAIKCESMFAFTLVEGWIKLSEATRNPKWKQFAENAMVYVHENVKDPVGRYSKRWDDKNTEPLNRWNLLFPAATARAYWALVAANTSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU5</accession>
    <name>A0A1U9NMU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69048">
        <property type="protein sequence ID" value="AQT69048"/>
        <property type="gene ID" value="STSP2_02233"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02233"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="420" mass="46364" checksum="242B7E9C73D4A573" modified="2017-06-07" version="1">MVNHRELVRKSLDHVDPGKVVVDFGSTPVTGMHVLCVARLREHYGLEKKPVKVSDPYQMLGEIEPDLLDAMGVDTIGLAPPATMFGFKNNNWKEFTTPWGQEVLVGGDFNVTKDSNGDLLMYPQGDTDSMPSGRMPASGYFFDTIIRQEPIDEDKLDPADNLEEFGPISDEDLNYYKKQAGKLADSGRAVVSSLGGTAFGDIALVPAPFLKNPKGIRDITEWYMSTAMRPDYIHAIFSKQSEIAIDNLARLHDAVGEAIDVLLICGTDFGTQTSSFCSTETFDKLYAPYYKKLNNWIHANTTWKTFKHSCGAVANFMEHFIECGFDIINPVQCSAAGMDPKTLKESYGDRIVFWGGGVDTQKTLPFQTPEDVRQEVLSRCETFAPGGGFVFDAIHNVQANAPVENVVAMIEAVKEFNGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV6</accession>
    <name>A0A1U9NMV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnulokinase</fullName>
            <ecNumber evidence="4">2.7.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaB</name>
        <name evidence="4" type="ORF">STSP2_02440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02440"/>
    <dbReference type="EnsemblBacteria" id="AQT69251">
        <property type="protein sequence ID" value="AQT69251"/>
        <property type="gene ID" value="STSP2_02440"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02440"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="256"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54623" checksum="0AE48B0C03729D22" modified="2017-06-07" version="1">MGKNYIAVDLGAESGRVMLGNVSNDKLELKEIRRFENGAVDQDGTLRWDFARLFCEIKKGIGEAIEAAGGKVEGLAVDSWGVDFGLLDAEGDLVEYPYCYRDSRTDGMLEKAFELMDKRAIYANSGVQFMQINTVYQLLSMKLNNSPALARARTLLFTADLISYLLCGRKYAEYTLASTSQLMNMETGQWSQEIFDGLGLPIELMPEVVTPGIRVGELSPEICSELNCEPVPVYAAGSHDTASAVAAVPASDENWAYLSSGTWSLLGVEVPEAIVTDDAFEMGFTNEGGVGGTIRFLKNIMGLWLLQECRRDWKEQGRELSYGELAEMAGNAEPFFGFLDVNYDEFLAPGDMPAKINRYLEKTGQKTTEDKGQMARLILDSLAMRYRREIQKVEKASGRAVEVLHVVGGGIKNELLCQLTADAIGKKVVTGPAEATASGNILVQAMGAGQIDSVETARRIVTNSFDLAEYLPRDTAIWNEKYAEFIQLQERDEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX2</accession>
    <name>A0A1U9NMX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein YxlF</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yxlF</name>
        <name evidence="6" type="ORF">STSP2_02032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02032"/>
    <dbReference type="EnsemblBacteria" id="AQT68856">
        <property type="protein sequence ID" value="AQT68856"/>
        <property type="gene ID" value="STSP2_02032"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02032"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="46945" checksum="BDC2DD45711E1577" modified="2017-06-07" version="1">MSDKNGQYAVETVSLTKIFPDWWGRAKVIAVDDLNLQIKHNEVYGLLGPNGSGKTTTLKMLLSLLHPSKGMAFLLGGSSRDTNISSRVGYLPEESYLYKYLSAKETLEFYGKIFGLPRSVRKSRIESLLEMVGLAGMANRPVGTFSKGMARRIGLAQALINDPDLLILDEPTSGMDPIGTRQMKDLIMKLAQRGKTILLCSHLLADVEDVCDRIGIMYGGKMHVEGEVNSLLQHRDEVQIKTGQLSENAMSRIREIVQQDQGECEIEKPMDKLEEFFVRTVAEAQKAKQPTSGAVNSESATGFLTEEEKTEEEKESVLDGLVGSKKPDQPKQQSEAETTSAGSETEQVSREKDKSDKPAQKDAILKDLTGGKSEQAETEKVSKSKPEEVKPESTEDIKDDLLRGLMDRGDGATDKPKKDEQGGSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN02</accession>
    <name>A0A1U9NN02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02063"/>
    <dbReference type="EnsemblBacteria" id="AQT68886">
        <property type="protein sequence ID" value="AQT68886"/>
        <property type="gene ID" value="STSP2_02063"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02063"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="343"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="54247" checksum="274C4C5CF21C1524" modified="2017-06-07" version="1">MAYRYGDRYQRSLFPQSIDDYVPADSPVRAYDAFLDSLDFDELGIEINTGKVGCPQYDPVSMLKLLLYGYSYGVRSSRKLEREANYNISFIWLTGGLKPDHKTIAEFRRKNRGALKKVLRQCARLCIKLDLIKGNTLFIDGTKVRANASNKNTWTKEKCQRRLKSIDKRIKQILSECETVDRKEVNQGSWIKMDEELSDQKKLRSKVESIMEQIQAEDSKSTNMTDPDCKMMHSIQGSHSSYNVQSAVDDENGLIVNSDVVSDNHDYKQFADQVDKANDTLDNDCETACADAGYSSVDELEKIDEKGIEVVVPSKKQAEKKKKDDNPFDRSKFEYDKKNDCFICPEGHVLKYSYTNKTKKAKVYRGGAACRKCRHFGKCTDQQRGRSVSRLLNADVQEKLEARYEQPRAQEVYKRRKQKVELPFGHIKRNLKVDSFLLRGLEGVRAEASLLASCFNVARMMSLLGVEGLISTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN45</accession>
    <name>A0A1U9NN45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68936">
        <property type="protein sequence ID" value="AQT68936"/>
        <property type="gene ID" value="STSP2_02113"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02113"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640379" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44578" checksum="4F4F26624B51BC49" modified="2017-06-07" version="1" precursor="true">MIPLIRAALIFVCTTSFACLAQTTARWSMQWSHISNPVVRDSAFGLGEGPLGGAGGPIVEFDHLWYFGNAGFTASHEQPPQSLFSSGFFPHGTSYNAGAQFGDGILFFPQDQYGNEFDYHDSFTVEGFFKTHGNQSAAGIQQILLQGENDYSYGITINEGGPGWLCFGVNVTGDGIVTVKANAKNYADGSWHYFAARYDDPADTIELMTASTDGRTENKSVQLSSGTELITGGAGNMLIGRETFQGARQFAGLIDEIRLTNGYWANAHLMGRITAKYSPQPAPRQTGVTLMPQLQWDDGEDVFAYNVYFGQTDPPAYRSHQSGTTYYIPAELEPGTTYLWRVDRLLQNGTTIRGELWSFTTHYTECDGPMPHDYNGDCTINMQDLSHFAAAWLDCGLVPETSCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN51</accession>
    <name>A0A1U9NN51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stage 0 sporulation protein KE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF</name>
        <name evidence="6" type="ORF">STSP2_02561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02561"/>
    <dbReference type="EnsemblBacteria" id="AQT69372">
        <property type="protein sequence ID" value="AQT69372"/>
        <property type="gene ID" value="STSP2_02561"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02561"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36126" checksum="FFB1A8654AE45D31" modified="2017-06-07" version="1">MVSTNKYLVEVEGLKTHFPIKKGIFKKTVGHVKAVDGVSFNVPAGKTLGLVGESGCGKTTVGRTMLGLIPHTDGVVKFEGENVFDLSKKQMRLLRRDMQMIFQDPYGSLNPRMNVGTIVGEALEIQGLMSGRERRIKVAELLDRVGLAPQYASRYPHEFSGGQRQRIGIARSLALDPKLIICDEPVSALDVSIQSQVINLLQDLQNELGLTYLFIAHDLAVVEHISDFVAVMYLGKIVEYADAKTLYANPLHPYTQALMSAIPEPEPIKTKQRIVLSGEVPSPSNPPSGCPFHPRCQYAEDRCKEELQVLDTQEPGHMAACWKCKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN96</accession>
    <name>A0A1U9NN96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ORF">STSP2_02174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02174"/>
    <dbReference type="EnsemblBacteria" id="AQT68996">
        <property type="protein sequence ID" value="AQT68996"/>
        <property type="gene ID" value="STSP2_02174"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02174"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="329"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="396" mass="43428" checksum="0A73A23265755EF8" modified="2017-06-07" version="1">MKVLVINAGSSSIKYQLYQMPEANVLAKGVVERIGEAGSVLSQKSDSKEHVFETEIKNHKQGMNLILETLATGESKVIDDIQDIQAVGHRVVHGGEEFSGSVVIDDDVIASIEKFADLAPLHNPPNLTGIKAAQENLPNAKQVACFDTAFHASIPKVAYMYGLPYDIYEKYRVRRYGFHGTSHNYVARRAAEVLGKDFKDVKLITCHLGNGCSITAVKDGKSIDTSMGLTPLEGVMMGTRCGDIDPAIIFYLKDKGYDVDEINKMCNKQSGLLGISGKSNDMRNLLEAVDEGDKQAELAVDMFSYRIKKYIGMYFAVLNGVDAIIFTGGIGENSTPVRERICTDLSAMGVKMDTALNDETVRKEGKISTEDSSVNVYIIPTDEEYAIAHDTFELTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC2</accession>
    <name>A0A1U9NNC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02600"/>
    <dbReference type="EnsemblBacteria" id="AQT69411">
        <property type="protein sequence ID" value="AQT69411"/>
        <property type="gene ID" value="STSP2_02600"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02600"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29534" checksum="657A09C887E265B3" modified="2017-06-07" version="1">MALTFQTLISSSKGNCLVLSSRTTRLVIDCGFRSQKAVRAAFDQQFGLDGGPDAVLVTHLHGDHINYSALKVLQQRMVPLYIHEESVDLLPGKHFRGYRFAELDVNSYAARSFVIGDLTVRPIEVPHAPGHLTHAFEIAHDGRRIVVAADFFDAAAIRDVMIDADFVYIESNHDLQLLRENWNPNSRWHMPNPITAELICEVADISEKPPTAVMLGHLSEQRNRPEIVLDEMHTAFKRKRLNMSFDLTVAPLYEASHVIQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND4</accession>
    <name>A0A1U9NND4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02602"/>
    <dbReference type="EnsemblBacteria" id="AQT69413">
        <property type="protein sequence ID" value="AQT69413"/>
        <property type="gene ID" value="STSP2_02602"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02602"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="529" mass="57389" checksum="6E7A8F2720B1C7E3" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN4</accession>
    <name>A0A1U9NNN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69531">
        <property type="protein sequence ID" value="AQT69531"/>
        <property type="gene ID" value="STSP2_02722"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02722"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="72" mass="8021" checksum="79474018765FAEC1" modified="2017-06-07" version="1">MDVWVLKASSITRRKQMVLRSRLDALLKVALLGEIQTKVATSGRLEGTATKNGVTSVWQIKKKRVKAKERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV0</accession>
    <name>A0A1U9NNV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphodiesterase YaeI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02479"/>
    <dbReference type="EnsemblBacteria" id="AQT69290">
        <property type="protein sequence ID" value="AQT69290"/>
        <property type="gene ID" value="STSP2_02479"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02479"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33880" checksum="D5DC148C8CC219D6" modified="2017-06-07" version="1">MRKISEQRRLVETEGVEHAVVRGRIGRWHFENMPRLQKVLYGMLKMSGTEGFGRRHAMEVQVVEVEFEFDNLPGAFDGYRVLFLSDFHIDGLPELAEIVLEAAGKVEYDLCVLGGDYSFDHHEECDEAKGLMRQVGGVLAERSRVVGVMGNHDRYSMGEVLAECGVEMLLNESVRVERGGEAIWVAGVDDYHYFGAHDFDMADEGIEEGAFKVMVCHTPEGWREAAKRGYSLFLAGHTHGGQVCLPGGVMLVRGATVRRGMLRGAWRDGEMAGYTSRGVGVSGIPVRHWCRPEMTVLTMRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW8</accession>
    <name>A0A1U9NNW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02797"/>
    <dbReference type="EnsemblBacteria" id="AQT69603">
        <property type="protein sequence ID" value="AQT69603"/>
        <property type="gene ID" value="STSP2_02797"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02797"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="31046" checksum="68CA00CA17DCD097" modified="2017-06-07" version="1">MPYEKRIIIGGLPRSGSTLLRFMLDAASTIISGPETAFFTQPLFQQQATIARLAQRLADKLNICPERLTEAVITAPTSCQAYDSISDLMGENAGISKPCWAEKSPRNCFSYHRLHAENPNFYFISTIRHGLDVVTSVVKNHPNNANQYWCPIQRYVDTMLAIYSFKSPRHLIVKYEDMVTSPQKTMNQIFAFLGLKYEDHIIQSFRQPASTRDLTKVHQPKLKQEISSDWINRWKALQHSERVNEFMQHSKAVYWLEHSGYELPQRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP45</accession>
    <name>A0A1U9NP45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69286">
        <property type="protein sequence ID" value="AQT69286"/>
        <property type="gene ID" value="STSP2_02475"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02475"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23498" checksum="BC7970E115CFF26E" modified="2017-06-07" version="1">MGKSKGKWDIDWKKIGRNMGKVTEPDQGVGTGKSCRDETEETGGVRAARVSTPQRPMVPRERGAESEAQGGTAVMIADEGVEAEQRDEFESGEIDMDMVTKNEPVRVNDAGNVEPNRFAGNGGQESQGGSNAGGRDTESGMDLLSVDFMLGVVESTAGSDENDVVMRKLSFNELLRVGARGEIDSRALQVYAVDAAGLYGKDIQRQAMEELALRTGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP99</accession>
    <name>A0A1U9NP99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69627">
        <property type="protein sequence ID" value="AQT69627"/>
        <property type="gene ID" value="STSP2_02821"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02821"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346509" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36442" checksum="1DC67387BD85FF9E" modified="2017-06-07" version="1" precursor="true">MKVANFSLFVLVVVSANAFCSTAVVFDSNYRSEVYATYPSSKSLGQVGGMEFDSEGNLFVSHYGAEFEGNDGSIYKITPDGNANEFVSGLHFPGNMVWTGGTDYGDYLYVGDGTRPTNGRRGGIYRVDMQGNISPFATAGNEPYALGFDEEVGMMFAGTRGDDHLDKVLSDGSTQLFSGFPYGMNGGGPAGIDINNGDKYPGYMYLSNDGKGENYSGVFKLDENGSASRVAEGILTSFRLGFDDVGDFDNSLFATGISREHPGLWSLYKIEEDGTYSLFATGGDMHLNVFTFGPDGAIYAATRAWYSDKVTISRISLIPEPATLALFGVGVGAILRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD1</accession>
    <name>A0A1U9NPD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">epsF_7</name>
        <name evidence="9" type="ORF">STSP2_02970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02970"/>
    <dbReference type="EnsemblBacteria" id="AQT69773">
        <property type="protein sequence ID" value="AQT69773"/>
        <property type="gene ID" value="STSP2_02970"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02970"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="399" mass="44004" checksum="89491073112A9159" modified="2017-06-07" version="1">MATFEYKAKDESGSVFSGVYTDVENTNELRSGLEKMGFDLVKAKKVKSASGNKKLKIKTTEIVSFAYEFAGMYQAGLSVMRCLQTFEEQTENEDFKSVIADIRHNIETGATLRQAFGKYNYVFSDFFCGMLDSGESSGKLAESLEMAAVYLDKQNELKGKVKQALTYPVVVCVMCLLIVTALVIFVIPVFQKLYSQLHITLPMPTQVLITLSNITRNYWFIALPVCLAVGYGVPKLCKMPSLRGKIDMLKLKLPVVGQLNRMLLVSRYVRTFAMMSASGVPIIQSLELAREVAGNSSVDPITDALQERIQTGGSVSAAMSEYDLFPPVIVQLAGAGEEAGVLPEMLIKGVEFYDRKIEKTIKSVLVKIEPALSVLLGLIVGSIMLGVYLPMFDYMGQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG4</accession>
    <name>A0A1U9NPG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_02828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69634">
        <property type="protein sequence ID" value="AQT69634"/>
        <property type="gene ID" value="STSP2_02828"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02828"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSC" evidence="7">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="36487" checksum="212663E273324ED4" modified="2017-06-07" version="1" precursor="true">MIRLLRIATFICIILAVATMAWVGFNAFKYKPAEHAIMQEPGPVEIMKKIALDTGNKDTVSPLVKQAKAFKLRIDPPEPPKPDPEERTQNRQIAENPNPEPQPRPEPKRVNVTRANFKLVGTCRYIDQPQKSLALIDLPAEGQKWVRLGETVRHHVIAEIGDDMVVLDQNGRKSNLYAPEKNSVSLLKNPPADSTTTSTVTAKAANIEHKAVPNQTRPSTQANANRSRGRKPPVSARKAPVKRQTPQERKKMLDSNIADIQQVMKRSSNVDATPEQKKQEMQAWSSLLKLLEEDRKRVEKQTQQSDNDKEQPEPKQAESEDKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG8</accession>
    <name>A0A1U9NPG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">STSP2_03030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03030"/>
    <dbReference type="EnsemblBacteria" id="AQT69832">
        <property type="protein sequence ID" value="AQT69832"/>
        <property type="gene ID" value="STSP2_03030"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03030"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="27774" checksum="B8406E4093977FBF" modified="2017-06-07" version="1">MAITLRSRREIDLLRNAGAIVAKALSKLQQAVEPGISTGELDDMATAVAAEAGAATLFKGVESPYASQPFPGAICASINEQVVHGIPSHDIKLSDGDILSVDFGVKLNGYCGDSAMTMAVGNISPEKQRLMDVTQRLLDIAVETCKPGVKWSEVAGAMEKCALDAGFSVVEEFVGHGIGTEMHEEPKLQNFVNKELLRNDIMLKEGMILAVEPMVNMGKKSVKVLKDGWTVVTRDRKPSAHFEHTIAVVKGGCEVLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPG9</accession>
    <name>A0A1U9NPG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69813">
        <property type="protein sequence ID" value="AQT69813"/>
        <property type="gene ID" value="STSP2_03010"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03010"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013182903" evidence="1">
        <location>
            <begin position="22"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="510" mass="54304" checksum="30E9037C0C79D52B" modified="2017-06-07" version="1" precursor="true">MRREVVMCLAAILLMGGFAAANTVWDPESNPDPDAIVNGTANWDVAENWSNGLPGDIDQKPVFNDAGAAVECQVTTDTLTFSSNLVIGDGGDAGILRVMDGGVITKTGGSWCAIAYNAGGTMIVEEGGQVLLDSHLWFGMNAGAVGELILDGGFVDVDDAMDLGRGGGTGLITINNGTLRMRYYPDDFDSETSVCDIKFGTLAIENNYATPPSKLWSRIDAGTIVGFGGLGTLNVERVDGLTLVTATSPMQPSPAYGESLLIDENTTTMLDLNWTNLDPNTPGDDVYVDVWFGTDPNKLDNQVYSQKVTAGQNTTTVQVPVEVIGTPPTKYYWQVDSYIYGADKINEENMIEGELFEFEVTDDAPPTVVIETPDTVTWVGEPVQLDATITDTGGSTQYIEWTASDASVSFSLDNTVEDPVVTAAAAAGEVTLTCTVWDELNGIEEANSDSIILHVAEDACAAAEVIGVAADYPMDVAEPFCVVDLNDLAAICADWLTDYELTEPTVIPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH6</accession>
    <name>A0A1U9NPH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69821">
        <property type="protein sequence ID" value="AQT69821"/>
        <property type="gene ID" value="STSP2_03018"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03018"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21412" checksum="F397DD3744238D50" modified="2017-06-07" version="1">MSKGLKNSHKNCGVLVLKLFATAASLTLPLVPLTYIAYSNTLSASGGAVVFFCLSLVAAASAFCYRPTYKVIILFAALVLASMLSSLMGPILLFFMCIFAGAFGVNLLPTKWNRFSIWIIPYVIARAVLAGIVFFLVASKIQLNECVLLTSKFDSLCSFTAIFILALLIFDLCGLGLRYCFRGYSLSRQTNSSDEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK2</accession>
    <name>A0A1U9NPK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pimB_2</name>
        <name evidence="3" type="ORF">STSP2_02626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.57" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69436">
        <property type="protein sequence ID" value="AQT69436"/>
        <property type="gene ID" value="STSP2_02626"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02626"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="82"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="46382" checksum="9F26C3DC439C5E42" modified="2017-06-07" version="1">MMGPSLKIVFVSSFKPRKCGIASFTSDLISSTKMLQGERFFPEVIALESDGEFQYDKPVTLRLRKNAEYHYVYAADYVNMSDVDMVCIQHEYGLFGGEAGSHLSIFLERVKKPVITTLHTILDKPDVKQFELLKEICGRSDKVVVMSYRGATLLKELYRVPARKIIHIPHGIPDFPFSESTSWKRELNLGDRRIITTFGLLSPNKGIEIMLKALTTIIKTDPSVLYMVLGTVHPEIVRREGYTLQTDLAKKAKQLGVAGHVAFYNRFVSDRELLTFLGATDVYVSPYLHPEQVSSGTLAFAIGFGKAVVSTPFYAAQELLADGRGKLVDFGNSEELADTVIDIITHPGKLWDMRRRAYAYGREMRWSKVSRAYWDLFLSCLENRTESYNIVTTDETRLPFLPHNARNKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM1</accession>
    <name>A0A1U9NPM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00619</name>
        <name evidence="2" type="ORF">STSP2_00654</name>
        <name evidence="3" type="ORF">STSP2_02982</name>
        <name evidence="4" type="ORF">STSP2_03249</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67472">
        <property type="protein sequence ID" value="AQT67472"/>
        <property type="gene ID" value="STSP2_00619"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67506">
        <property type="protein sequence ID" value="AQT67506"/>
        <property type="gene ID" value="STSP2_00654"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69785">
        <property type="protein sequence ID" value="AQT69785"/>
        <property type="gene ID" value="STSP2_02982"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70047">
        <property type="protein sequence ID" value="AQT70047"/>
        <property type="gene ID" value="STSP2_03249"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00619"/>
    <dbReference type="KEGG" id="alus:STSP2_00654"/>
    <dbReference type="KEGG" id="alus:STSP2_02982"/>
    <dbReference type="KEGG" id="alus:STSP2_03249"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="19083" checksum="65DF7B06CD076F1D" modified="2017-06-07" version="1">MCLYARDLSTSEGQQIQRILRSSKSRIKIRRGQVILASNQGYKVPAIAELVHYSPHHVRVIIKDFNQRGLKALEPKPRPGRPPEFTEDDKAIIAETAKCPPDLLDCPFKRWSLEKLREYLVQEKIVPTISIETLRTILREKKVKLRRTKTWKECNDPNLKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP7</accession>
    <name>A0A1U9NPP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol:disulfide interchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03101"/>
    <dbReference type="EnsemblBacteria" id="AQT69901">
        <property type="protein sequence ID" value="AQT69901"/>
        <property type="gene ID" value="STSP2_03101"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03101"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798485" evidence="1">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="38185" checksum="80C33F73DA57EC8A" modified="2017-06-07" version="1" precursor="true">MSKPKQILIQTLLAAALISSAFAEETEKGQKVVITAAPARRLAGARIKKEVTWPDNYKQAISKAKRQKKDLLIAFTGAKITQPAALLTAKVLYKEDFYEKASRSFTMLNIDCPPNAKLNEYLSEQLYVLTNKYKVDNLPTLFITSPDGTPYQVTGFIPKTATPEKYLQHLLELKKKKNEMVDLFEKAEDEDSATKKAKLLDRALSMTNPALARNFHNEKIDFIITADKDNSLGLRNKYAVPRQLEKAYRAIETRDYKLAKTIIDTTIRELRPDGPLLQQLYYARSQAQFHLENPQGQLDSLNRALQAAPQSPMADQIKRTIAYYFTAPTENSTQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU2</accession>
    <name>A0A1U9NPU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate import ATP-binding protein PstB 3</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB3</name>
        <name evidence="6" type="ORF">STSP2_02717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02717"/>
    <dbReference type="EnsemblBacteria" id="AQT69526">
        <property type="protein sequence ID" value="AQT69526"/>
        <property type="gene ID" value="STSP2_02717"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02717"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="49"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32942" checksum="69CB71EDA5ED8663" modified="2017-06-07" version="1">MPFDIAGTRQMQKRASSANKKAEKMPQIKINSSNQPDPEPRPVKDKPIITSEDFCLYYGSKAGVQDISMEIYPTSVTAIIGPSGCGKSTFLRSINRMNDLIPHTSAKGQLRVNGSNVYDKQINLVNLRQQVGMVFQKPNPFAKSIYDNIAYGPRLQGIRNRARLDEIVETCLKSAALWKEVKDDVNKSALALSGGQQQRLCIARTLATEPKVLLMDEPCSALDPIATGRIEDLINELKDKYTIVIVTHNMQQAARVSDMTAFFCMGELIEYDQTDRLFTNPAEKQTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV6</accession>
    <name>A0A1U9NPV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69973">
        <property type="protein sequence ID" value="AQT69973"/>
        <property type="gene ID" value="STSP2_03173"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03173"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="34940" checksum="E6D08A5DEC927BAA" modified="2017-06-07" version="1">MAKKYWYGGATDHLGEWDYDNAAGGYTGSNWRLVADDTGCAKPAAGDEVFIDNRAAYNDTDGRYQDIDTNIDATGTGTPDLAAVTISADYDGNIGADGSYLELECSGDAVIEGEGSVYLKVSAGTGVNADVDRLVVNKAQGTLYLSGAENDGSNVAKFAEILAISGTLSIADSTAVDKLTSFEAATISAGSGCKDVLNGTLADLIIVGGTVTWNSPIDTVDIFGGMLRWGSDGDTATGLDCNLANIYPAGRLIWQTADTDVSILKKFVCCGGTLDAQQPTNSQYRKQIGSGASEVSEAWYNSNLRLAARTLSLASGSSIKNYGARITAPAGDSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX2</accession>
    <name>A0A1U9NPX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">epsE_5</name>
        <name evidence="3" type="ORF">STSP2_02971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02971"/>
    <dbReference type="EnsemblBacteria" id="AQT69774">
        <property type="protein sequence ID" value="AQT69774"/>
        <property type="gene ID" value="STSP2_02971"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02971"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="587" mass="64343" checksum="D7E903D5A733FB04" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ4</accession>
    <name>A0A1U9NPZ4_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_03095"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22855" checksum="27494635A14E172F" modified="2017-06-07" version="1">MDWDCNGLLALIAIIPIFILVGRQKVKKDGYLWKRKFKGIATKSIRKRMRKSDIFIAACALVYLTINVLFSLKLLSLSSGEEQKNVESFVLLSSAWAFWFPVLGLQIPMLSFFEVRLTTTKRLFLGVWFLIPLGMSIFAALITGEIQLIREGLISSSILLLFCGPAIIVGKDFLRFYSGLCGKIVMLGLDRDKYRLYGEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ37</accession>
    <name>A0A1U9NQ37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">obg_2</name>
        <name evidence="5" type="synonym">obg</name>
        <name evidence="9" type="ORF">STSP2_03097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03097"/>
    <dbReference type="EnsemblBacteria" id="AQT69897">
        <property type="protein sequence ID" value="AQT69897"/>
        <property type="gene ID" value="STSP2_03097"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03097"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="159"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35771" checksum="0ECCF7B6F19F4DF1" modified="2017-06-07" version="1">MFVDEAKIWVKAGDGGHGCVSFRREKFVAKGGPDGGDGGKGGDVYFLASQEIDTLVDFAGKHHWRAKNGMPGEGSNKAGAGGEDLVIKVPVGTIVYDTDIDMMIKDMDTPGMEVRIVRGGRGGRGNKSFASSTNQAPRMATDGKVGQERNLRLELKLIADVGLVGLPNAGKSTLVSRSSHARPKVANYPFTTLEPVLGIVELPGFRRFVMADIPGLIEGAHDGAGLGHDFLKHIERTRILLHLLDIQPDDNSDPVGNYHKIKNELAMHSKTLAEKPEIIAVNKTDLDPDGEYTQDIIDRLGVDGVMGVSAVTGEGLDELNEKLWRVVKGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ50</accession>
    <name>A0A1U9NQ50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III PolC-type</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">polC</name>
        <name evidence="2" type="ORF">STSP2_03264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03264"/>
    <dbReference type="EnsemblBacteria" id="AQT70062">
        <property type="protein sequence ID" value="AQT70062"/>
        <property type="gene ID" value="STSP2_03264"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03264"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
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    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="321" mass="36134" checksum="18D75AEC6A3FA577" modified="2017-06-07" version="1">MAAVKGIKELSIYETPIAVIDFETTGLTPGVDRVVEVSVYRMEPGKKPVLAFDTLVNPQRPMSATEIHGITEDDVANAPVFSDIAGGLVDSLSGCVVSAYNVYFDIKFLAYELNQLGIPQTPPHFCLMYMRPMLGLGKRCNLEKACEYHNVDYKAVHIASSDAEASASLMERYLEEMTKQKVRTFGDLARLKKYKFTESFVASPMNGAGGLRLTKSERFLSRSGFQSSIEINPERQALAEYWEALRMVVADLEVTDEELAQMLQLRKEIHLPKEKIRMLHAKAFASVISQFIDDKWLDDKEVLKLRRLKRCLSRLGWAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ90</accession>
    <name>A0A1U9NQ90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIE_2</name>
        <name evidence="3" type="ORF">STSP2_03147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03147"/>
    <dbReference type="EnsemblBacteria" id="AQT69947">
        <property type="protein sequence ID" value="AQT69947"/>
        <property type="gene ID" value="STSP2_03147"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03147"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ftsk_gamma" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7530" checksum="8575CA5C77029D3A" modified="2017-06-07" version="1">MNESEKDKLFDEAVRVVREADRGSVSLLQRRLGIGYARAARLINSLEEAGVIGAYRVGKAREVLKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA8</accession>
    <name>A0A1U9NQA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69696">
        <property type="protein sequence ID" value="AQT69696"/>
        <property type="gene ID" value="STSP2_02891"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02891"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25516" checksum="34CEE16E35569DCD" modified="2017-06-07" version="1">MKRSILYVLVIFLVFAASGCGEPEREENVLKPSLACSGMKLKGETVVRYFNADGSEYITEQDHDFCVSNRSMLVTASEPTGDYIWKLKGGTFRTRPEGGQSEELLSRLEAEAINMSMLAGAGFVSLDGVHTGEPVRLSGRWYTPIEIKGLFAGQISKTVYVNRTSRKVDMVRVEDLKSGEVVSTLVFNYGYINKLDQPVPMKIEVYSTDVDSIDPKKVISFEYSKLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC9</accession>
    <name>A0A1U9NQC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cysteine protease YraA</fullName>
            <ecNumber evidence="3">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yraA</name>
        <name evidence="3" type="ORF">STSP2_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03345"/>
    <dbReference type="EnsemblBacteria" id="AQT70141">
        <property type="protein sequence ID" value="AQT70141"/>
        <property type="gene ID" value="STSP2_03345"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03345"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18498" checksum="5DE432533C5453A5" modified="2017-06-07" version="1">MKALILVAGGVEDMEFYYPFYRLKEAGIPVDVAGPEKGKVHGKHGYPVDINESLSSIHADDYDLLILPGGKSPETVRLYSRALEVTRQMMEAGKCVAAICHGGQVLVSADVLKGRRATCYKAIRDDLKAAGATYVDEEVVVDGNLITSRVPDDLPAFFREINNMCAAHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE6</accession>
    <name>A0A1U9NQE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69948">
        <property type="protein sequence ID" value="AQT69948"/>
        <property type="gene ID" value="STSP2_03148"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03148"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9371" checksum="49A9A961E6CD53F5" modified="2017-06-07" version="1">MDKTMKRKIEGLASIACGLLLWAVFGLLVLSCHLWWQDEWTSEVYTSAKFGPMLFFGITGIILIVGSLGLVAFGVIRFFDVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN7</accession>
    <name>A0A1U9NQN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ORF">STSP2_03024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03024"/>
    <dbReference type="EnsemblBacteria" id="AQT69826">
        <property type="protein sequence ID" value="AQT69826"/>
        <property type="gene ID" value="STSP2_03024"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03024"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16502" checksum="8D369B1060163035" modified="2017-06-07" version="1" precursor="true">MRHRVAGRKLSRTSSHRLAMRRNMVASLFEHETISTTLEKAKEVRGFAEKLITLAKKGTLPARRQAIALLNNRDIYEEQDGENQKVGTVIGKLFTEIGPRYLDRPGGYTRIIKLSKRRLGDNGQLVLLQLVGEEAGSKKETEKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ7</accession>
    <name>A0A1U9NQQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70058">
        <property type="protein sequence ID" value="AQT70058"/>
        <property type="gene ID" value="STSP2_03260"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03260"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="390" mass="44206" checksum="5EA40BEA0EE3A668" modified="2017-06-07" version="1">MSPSVPSEYVGRRHKIPRYPAVYPSEFKYDEWEGEWICGLHLIIAPILTIVLFVILGIVGTFSWGLLFLTFIGVEIVLGGITALAVVSSENEEKKKYYERHCNRLLKEASEAIDVNNGWYDYLTTYDILSEIEFVPRNSLTSFEIIGRRGAEIAVACQDYEYATAFYGLLIDVTDSERARTCLALLHQRINRETDSEASKTGLMKILAFITLIFLVLVIIGWAGWFFHQNKEAQPVGAENRQGQELLQNARGSLQRVSHELENNVEPSIARLDQDRKNLVLKLRGMGVRESEDIKGNYKGAVLAKELAEVVQYLDGLNEKKEAYLQSKFELGVLIRRLKRQEIALDAGLSQEEIKQVDISLRTIDARLSEIGENDPIEIETVLEQELVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR8</accession>
    <name>A0A1U9NQR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper-exporting P-type ATPase B</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">copB</name>
        <name evidence="8" type="ORF">STSP2_03331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03331"/>
    <dbReference type="EnsemblBacteria" id="AQT70127">
        <property type="protein sequence ID" value="AQT70127"/>
        <property type="gene ID" value="STSP2_03331"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03331"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="680" mass="73840" checksum="721B3F3BD21FE921" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS3</accession>
    <name>A0A1U9NQS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_03488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70282">
        <property type="protein sequence ID" value="AQT70282"/>
        <property type="gene ID" value="STSP2_03488"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03488"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012414399" evidence="2">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="149"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="46187" checksum="8AA9C61078F16724" modified="2017-06-07" version="1" precursor="true">MDRRKFLSTTLAAGTIAALKPVSSFAAETEKEQPKTTDMQFLAGPYLQAPTETSMTIMWITDKKSTAEVHWGEDESLGKKAISITDGQIDANERIHKVTVTGLEPGKKYFYKVSSREITNYGPYRVDFAGTRESGIHSFTTLDTNKESFTFIVLNDIHSLADAMKKRLELLDDIDCDLVMLNGDIIQDPKSEQQIIDYTLKTLTDAFAKEIPFVFIRGNHEARGVYSRLLEKYIATPNDKYYFTFEHGPAQFLVLDGGEDKEDSHWAYSGLNAFDQYRVQQAHWLEQKIELGEFKNAPYRICLTHIPLFGSGDAHGTLDCRDKWADLLQQANIDLHISGHTHRPNILAPSEEHNYPIFIGGAPQYGRGTIVQVDVTKDKMQVKMIEDNGEVFGTYQIKPDRKPFLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR19</accession>
    <name>A0A1U9NR19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">asd</name>
        <name evidence="15" type="ORF">STSP2_03399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03399"/>
    <dbReference type="EnsemblBacteria" id="AQT70194">
        <property type="protein sequence ID" value="AQT70194"/>
        <property type="gene ID" value="STSP2_03399"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03399"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="14">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36217" checksum="87AE82C2A792CA8D" modified="2017-06-07" version="1">MGKRLAIAGVTGAVGQEFLQILDQRDFAFDSIKMLASKRSAGKKVTFKGKEYTIEELTEDSFGDVDIALFSCGGSRTKEFGPAAVKAGAVVVDNSSAYRMDPEVPLVVPEINAEAMKQHKGIIANPNCSTIIAIVPVWPLHKANPVKRMVVSTYQAASGAGMAAMRELEQQARQVLNGEEVTCDALKYQLAFNCYNHDSQTAPNGYNAEEMKMVNETRKIFDCPDIGISATCVRIPTLRAHCESINLEFESPITPDEVRELLSTAPGVTVMDDPENNRHPMPTDASGKDDVFVGRIRQDESVPDNCGINIWVAGDQIRKGAALNAVQIAEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRC9</accession>
    <name>A0A1U9NRC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03533"/>
    <dbReference type="EnsemblBacteria" id="AQT70327">
        <property type="protein sequence ID" value="AQT70327"/>
        <property type="gene ID" value="STSP2_03533"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03533"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28244" checksum="CD81B4410C8A1A26" modified="2017-06-07" version="1">MKLAKRHKYVLMALGFYWPAIFIATHLPKVPNWVGEARMADMTWHFLAYLVLVTLIWLAVSPNKRVDWRRAKAWLILAGVIWYGVMDEWLQGFVGRGVEMQDFVGDVAAAVTALVLFTLFEFWMGLMWVTAIILFSVVNLSRIDTVCNSEMMNSAFYFLGYAFMTLVWVQWIDQKTDLRRDAVKWFAAGMGLPIAYGTFVELWSLAIGKNVWWMDCVTGISAVAAVVAISYATCHCGEEWKRISEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRE8</accession>
    <name>A0A1U9NRE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clpP_1</name>
        <name evidence="5" type="synonym">clpP</name>
        <name evidence="8" type="ORF">STSP2_03310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03310"/>
    <dbReference type="EnsemblBacteria" id="AQT70106">
        <property type="protein sequence ID" value="AQT70106"/>
        <property type="gene ID" value="STSP2_03310"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03310"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23857" checksum="64E279A48D1CE594" modified="2017-06-07" version="1">MHLSYPQHQVPKNIEQHMQVSSGYQRTREMTLSDMLLENRVVFMVGEINYPLATDVIMKLLYLDNTKPGSEISLYINSHGGAVDDTMAIYDTMRFIKSPISTFCIGRAQSGAAVILAAGAEGQRHALPHAKIMLHQPWGGVTGQAADIKIQAEEILKAKAEINKILARHTGLNADQIQEETERDKYLSADEAKEYGLIDEVLHEPEEEKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRF7</accession>
    <name>A0A1U9NRF7_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03504"/>
    <dbReference type="EnsemblBacteria" id="AQT70298">
        <property type="protein sequence ID" value="AQT70298"/>
        <property type="gene ID" value="STSP2_03504"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03504"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30883" checksum="085657047B84D84A" modified="2017-06-07" version="1">MQINELTQKIIAEKPRTILVLGACDTGKTTFTLDLAKRLVQHSPTAILDSDTGQSHIGLPSTIAYANLTPGTTDYQSLTANAPAFIGDVTPTGHLLQFCAALHNCLRSAREHAHTVLIDTPGYISDSTARALWHETYRLIAPDLIIALQKENELEHILASLPKNARITRIIAPSHIPAKTPAARRAYRSNLFRRYFNNARTWTVDLKTTPYQSRSNLTPQNIANRVLALRNYNSHDTALAIAKEYDPRTRQLTILSPATPCSDIAALIFGDFTLEPAAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRH5</accession>
    <name>A0A1U9NRH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70220">
        <property type="protein sequence ID" value="AQT70220"/>
        <property type="gene ID" value="STSP2_03426"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03426"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4343" checksum="BC2088229AF72BFC" modified="2017-06-07" version="1">MGLKSSISALKINFSFENLSKLIPHTAESVKLMYAKMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRU7</accession>
    <name>A0A1U9NRU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xpsD_3</name>
        <name evidence="6" type="ORF">STSP2_03452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03452"/>
    <dbReference type="EnsemblBacteria" id="AQT70246">
        <property type="protein sequence ID" value="AQT70246"/>
        <property type="gene ID" value="STSP2_03452"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03452"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012459825" evidence="5">
        <location>
            <begin position="35"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="576"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1336" mass="146055" checksum="27C07AC86DCAC3C5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRZ0</accession>
    <name>A0A1U9NRZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sucD</name>
        <name evidence="4" type="ORF">STSP2_03492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03492"/>
    <dbReference type="EnsemblBacteria" id="AQT70286">
        <property type="protein sequence ID" value="AQT70286"/>
        <property type="gene ID" value="STSP2_03492"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03492"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_CoA_lig" evidence="3">
        <location>
            <begin position="168"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="691" mass="74775" checksum="91AC95C19EFD6581" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG56</accession>
    <name>A0A1U9NG56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose synthase subunit BcsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66912">
        <property type="protein sequence ID" value="AQT66912"/>
        <property type="gene ID" value="STSP2_00050"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00050"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="211" mass="23338" checksum="598CDF450D911913" modified="2017-06-07" version="1">MKENNKLNFPASLRLTDQSAEEGFTALTELGDCYLSVGDHQQAQLCYDQAADIDPDRAEPYVGIGAVAFQNGNTDEAENAFKVALRLDRTNAKAHCGLAMIYHNAGAYTEAFDRYLKCLEQDTDNLSALLGLFQTSCQMGSFEKVTHYLEVYLSMHPDDHSVMFCVATLYMRDGKLQKAQRALNAVLKADSDNTDAAALLEEVEHQLAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGC3</accession>
    <name>A0A1U9NGC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_1</name>
        <name evidence="6" type="ORF">STSP2_00119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66981">
        <property type="protein sequence ID" value="AQT66981"/>
        <property type="gene ID" value="STSP2_00119"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00119"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="395"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="499" mass="55666" checksum="7A75494319CA0482" modified="2017-06-07" version="1" precursor="true">MNAGRYNRRDFLKLAGFAAGAAVTGCTGAAQNAGSNGGKSGKPLNFVFILADDLGWKDLGVYGSEFYETPNIDRLASEGMLFTDGYAACPVCSPTRASIMAGKYPARMDTTDWFGAPQPHNVRGHWLKKPLLPAPYVPQLPLEEVTIPEALKQHGYKTFFAGKWHLGHEGFYPEDQGFDVNIGGYFRGGPYTGKRYFSPYDNPKMENGPEGEHLPIRLGKETAKFVTENKERPFLAYLSFYSVHTPLMTTEELKKKYQQKKKEMGLEAEWGKQGERRERLVQEHAVYAGMVEAMDTAVGIVLDELEEQGLAENTAVMFMSDNGGLSTSEGHPTSNVPLRAGKGWIYEGGIREPWIVKWPGVTKPGSTCDEPVISTDFYPTMLDMAGLPLMPEQHKDGVSIVPLLEGGDSLDREAIFWHYPHYGNQGGSPSAAVRAGEYKLIEWYEDDSVELYNLEKDISEEHDLSEKMPEKTAELRMMLHEWQEEVDAKMPKRNPNAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGD3</accession>
    <name>A0A1U9NGD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66991">
        <property type="protein sequence ID" value="AQT66991"/>
        <property type="gene ID" value="STSP2_00129"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00129"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25617" checksum="2574B6C7DFDE9079" modified="2017-06-07" version="1">MHTNTNNEKPNDIRLHEMSTAGQDKAGRVFKHKICVVATRWDEVNALAEDMYKPIGAVEWRCTNTSRLPATDEQKRKYNSEGPYCAHSEPIHQNLGYEKDYHRAGWAIIGLGIIAALGSKPALCGGIIILVILVSAGLIISNDRNLLFAKVMLAFFSLCTAASILAVIDDLLDRDPATISWQTITTEENVFLTFLLAWLLITVTLLTRLIWRAHRCKTKSSSSKNAPGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH5</accession>
    <name>A0A1U9NGH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67042">
        <property type="protein sequence ID" value="AQT67042"/>
        <property type="gene ID" value="STSP2_00181"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00181"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6972" checksum="00DD14C1D8081097" modified="2017-06-07" version="1">MKAVKIVIGSLFAVYAVLQLLTLFGRLAGDNDTAYAQSALFGNISAIAIGAVIAFACFRSAFKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH9</accession>
    <name>A0A1U9NGH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgK</name>
        <name evidence="9" type="ORF">STSP2_00053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00053"/>
    <dbReference type="EnsemblBacteria" id="AQT66915">
        <property type="protein sequence ID" value="AQT66915"/>
        <property type="gene ID" value="STSP2_00053"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00053"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="615"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="662" mass="70328" checksum="1399C6DFB1A95DFD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGI5</accession>
    <name>A0A1U9NGI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptidase</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00192"/>
    <dbReference type="EnsemblBacteria" id="AQT67052">
        <property type="protein sequence ID" value="AQT67052"/>
        <property type="gene ID" value="STSP2_00192"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00192"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="145"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40626" checksum="8B88080A43588DF6" modified="2017-06-07" version="1">MNEQVAKARLKAVRKQMKEKGFDALVLLCNENLTYMTGFTGHESALVIARSGMTMVTDSRYTEQAMGECFACKYYEHAKGLAKGVGEVLARFKNIETVGLETRCSYAAFDLLKKEIRKATKAKVKPASGLPEAVRRTKNDDEAKNVQRAGKIAFKALEETLGQVRVGITEKELGGLLDFTMRKMGSQAGFETIMAFGPNCSRNHHQPGSRKLRKNDTILIDWGARYNSYTSDTTRSLAVGKVNKQHEKIYYAVLEANLAGIEACKPGASLREVDAACRQVLRKHDVPVFKHGTGHGLGLEVHEAPSFSPRAKGVLKAGDIVTIEPGCYIAGKMGVRIEDDVLITDKGHKVLTKDKGFSFAKEKLQVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN8</accession>
    <name>A0A1U9NGN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cold shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA_1</name>
        <name evidence="4" type="ORF">STSP2_00244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67103">
        <property type="protein sequence ID" value="AQT67103"/>
        <property type="gene ID" value="STSP2_00244"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00244"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7436" checksum="3B1E00F088619C62" modified="2017-06-07" version="1">MNEGTVKWFSDQKGYGFITPDDGSDDLFVHYSEVQMDGFSTLKENQKVTFEVGQGRKGLCAKNVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR3</accession>
    <name>A0A1U9NGR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apu_1</name>
        <name evidence="3" type="ORF">STSP2_00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67119">
        <property type="protein sequence ID" value="AQT67119"/>
        <property type="gene ID" value="STSP2_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00260"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010742140" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120083" checksum="4CC5ADDCD7C2F30D" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR6</accession>
    <name>A0A1U9NGR6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metX</name>
        <name evidence="2" type="synonym">metXA</name>
        <name evidence="5" type="ORF">STSP2_00095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00095"/>
    <dbReference type="EnsemblBacteria" id="AQT66957">
        <property type="protein sequence ID" value="AQT66957"/>
        <property type="gene ID" value="STSP2_00095"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00095"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010743">
        <property type="entry name" value="Methionine_synth_MetW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07021">
        <property type="entry name" value="MetW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02081">
        <property type="entry name" value="metW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="53"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="609" mass="68143" checksum="3B6C249EE658D25E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH04</accession>
    <name>A0A1U9NH04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease III</fullName>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdg</name>
        <name evidence="4" type="synonym">nth</name>
        <name evidence="7" type="ORF">STSP2_00356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00356"/>
    <dbReference type="EnsemblBacteria" id="AQT67213">
        <property type="protein sequence ID" value="AQT67213"/>
        <property type="gene ID" value="STSP2_00356"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00356"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="247" mass="27777" checksum="4ABD16712537B197" modified="2017-06-07" version="1" precursor="true">MAKKAAKKKVKKTKKKAAGKKTHRKKIKVDPAQAKKRVEKIFPVLVEAYPDARVSLNFSNPLELLIATILAAQCTDARVNIVTADLFKKYRSAEDWANADEEELQQDIRSCGFYRNKAKSIQKTCRAIIDKFGGEVPYTMEGLLELNGVGRKTANVLLGNAFETQGIVCDTHVIRLSRRLALSENRDPVKLEFDLMQIVPKEKWGGWTMFSHVLVFHGRAICNARKPDCENCPIAKHCPSAGKPELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA7</accession>
    <name>A0A1U9NHA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67138">
        <property type="protein sequence ID" value="AQT67138"/>
        <property type="gene ID" value="STSP2_00279"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00279"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6844" checksum="6B7B442E2A1E68CD" modified="2017-06-07" version="1">MTEKEIMEWMEKKVQTEGFSDAAALAKEFLQSHSITNSTDPDFPKVLDAGFKIAQQVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ2</accession>
    <name>A0A1U9NHJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arylsulfatase</fullName>
            <ecNumber evidence="11">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_00371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67228">
        <property type="protein sequence ID" value="AQT67228"/>
        <property type="gene ID" value="STSP2_00371"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00371"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012075419" evidence="8">
        <location>
            <begin position="30"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="10">
        <location>
            <begin position="406"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="481" mass="54749" checksum="ACCF5E3D7B8B94AC" modified="2017-06-07" version="1" precursor="true">MNRRAFLKKSCLSLTAIAASGCLSSQVKANPSQPNVLMICIDDLNDMIGCMKGHPQVKTPNIDRLAEQGTLFINAHCQAPICGPSRASLMSGLRPSTTGIYGQIYDNKIRNASDATRKCTYLHEYFQQNGYMTMGIGKIFHHHVPRGTLDVSGGRKKGFGPMPEEAMNWKGKGTVTDWGAFPARDEQMPDYHTAKWTIDKLKQKHEKPFMLIAGFLRPHVPWHVPQKWFDMYPLDEIETPAYLPGDQDDVPEIGRRIAEVPMMPTAEWAKENDEWREIIQAYLACVTFVDHYVGEILDALENSDYGDNTIVVLWSDHGYHLGEKNRFAKHSIWERATRAPLIIRHPGGKGGQRCSKPVQMLDIYPTLLDLANLPANSQNEGHSLTPLLRYPEGDWPYAAVTTYGRNNHAVRTERYRYIHYEDGSEELYDHKSDDNEWHNLADKEGYEQVKARLKKYLPEKNVPWSPAAFLGVNEYFRKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHJ5</accession>
    <name>A0A1U9NHJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="3">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="3">ADP-hep 6-epimerase</shortName>
            <shortName evidence="3">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hldD</name>
        <name evidence="5" type="ORF">STSP2_00546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="3">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67402">
        <property type="protein sequence ID" value="AQT67402"/>
        <property type="gene ID" value="STSP2_00546"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00546"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="37102" checksum="1456DBC769AAD24A" modified="2017-06-07" version="1">MIIVTGGAGFIGSALVAELNAQNQNDILIVDRLESDEKWKNLRKLRFADYVEADDFYDMLAAGDIDWPVQAILHMGACSDTWETDCSYLVRNNYECTKVLANWAVEEGIRFIYASSAATYGNGELGFTDDEDTIEDLKPLNMYGYSKQLFDLWAKRTGVLENIVGLKYFNVFGPNEYHKGSMRSFIIKAYEQIRDTDQVKLFKSYHPDYADGEQRRDFVYIKDAVDMTLFFLANPDVNGLYNVGTGNARTWVDLANAVFAAMDKKPKIEFIDMPDHLREKYQYFTQADMQKLSHADYKLDPTSLEDAITDYVQNYLQKDEFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL2</accession>
    <name>A0A1U9NHL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glyoxalase II</fullName>
            <shortName evidence="5">Glx II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gloB_2</name>
        <name evidence="5" type="synonym">gloB</name>
        <name evidence="7" type="ORF">STSP2_00555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00555"/>
    <dbReference type="EnsemblBacteria" id="AQT67411">
        <property type="protein sequence ID" value="AQT67411"/>
        <property type="gene ID" value="STSP2_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00555"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="6">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26518" checksum="EC0B1BB5136BE250" modified="2017-06-07" version="1">MHNVVILPALGDNYIYLYRYDGQRVFVVDPGDAGVVLENLQKHALDLTHVLITHSHGDHSAGAKKLKAETGATIFSPDSSAIRETDCDITDGQTLALPGSPVVVIGTPGHTSSAVCYYVPAGLDRPQPLLFTGDTMFIGGCGRIIGATARDFFDSLCRLKKLPDETLVFPGHDYTVENYEFALQVEPGSKVHEKRLAELRKISKQADMVPSSIGREKRENLFMQAGSAEEFAELRRKKDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHY8</accession>
    <name>A0A1U9NHY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00267"/>
    <dbReference type="EnsemblBacteria" id="AQT67126">
        <property type="protein sequence ID" value="AQT67126"/>
        <property type="gene ID" value="STSP2_00267"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00267"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011465">
        <property type="entry name" value="DUF1571"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07608">
        <property type="entry name" value="DUF1571"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32731" checksum="DB44E89974C1633A" modified="2017-06-07" version="1">METFRRSLCFGLSGGVEVGIAFLLLLGAAVFAGSEQDVRARRHLKFWNEREGVSAEDARGGVDPNIIELAKMDQISLYKKAIKHYDETIRDYTGKLMKHERVNGELRKKQVVRFKFKEDPFSVYMEWVKNAGSADKVLYVEGENDGNMVVHPTTLFGLIKSVERAPDCKEAMEENRYPVTMFGFRRMMANSLAMYEMADEKGELETVFLGITDVDGRKCLAIEGRLPDKKRYDRARVVVQLDVERLVPLNVISFNWDGELLGRYKFSDLKFNTGLSEAEFEAENNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI36</accession>
    <name>A0A1U9NI36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67437">
        <property type="protein sequence ID" value="AQT67437"/>
        <property type="gene ID" value="STSP2_00584"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00584"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="34903" checksum="0434CB5095A5B037" modified="2017-06-07" version="1">MRRLPLILILCVIGFVLIYIALRTDIFTRHKSKQAISREEYLARLNKPDISVEKLINEIEYATDDWQERYRNQLDYYLSRRYARLIAFLVEQMAEEGHFRLRFDEEWRKAIYEDHKPYKMEDPFDIEPIWRYTGKRTCFEVLKEDYGPGNESILQAVREEIADCSEKQCKPHFIYFLLKLFNEKLKADRYVYTDDDGAIIQVFNKYRTYRAEYVYQDIQRLLEIYKQYEKWPKIRNEVYFAILFVTLDFDLRDELLQEVDDHGLISAYQMLDSYKDQIWQKSKIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC0</accession>
    <name>A0A1U9NIC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00821"/>
    <dbReference type="EnsemblBacteria" id="AQT67673">
        <property type="protein sequence ID" value="AQT67673"/>
        <property type="gene ID" value="STSP2_00821"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00821"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="556" mass="61669" checksum="7E9409D7792AF9B1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID2</accession>
    <name>A0A1U9NID2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">murF</name>
        <name evidence="12" type="ORF">STSP2_00837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00837"/>
    <dbReference type="EnsemblBacteria" id="AQT67689">
        <property type="protein sequence ID" value="AQT67689"/>
        <property type="gene ID" value="STSP2_00837"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00837"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="308"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="517"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="310"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="656" mass="67942" checksum="6DC0217B345E7976" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE4</accession>
    <name>A0A1U9NIE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein YrrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yrrB_3</name>
        <name evidence="3" type="ORF">STSP2_00652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67504">
        <property type="protein sequence ID" value="AQT67504"/>
        <property type="gene ID" value="STSP2_00652"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00652"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
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        <property type="entry name" value="TPR_1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19892" checksum="559BEDB29FE19054" modified="2017-06-07" version="1">MKAYEEAIRLDPTFSFAWDNMGDALYKHCRYNQALEAYEEAIRFNPTFSCPWSGKGNVLNSLSRYDEALEAYDEAIRLDPTNSDPWNGKGYAFDSLGRSDQAFDAFDEAIRRDPTNSSPWTGKGNLFDKLGRYAEALEAYQKAIRIEPTCVAPWNGKGNALVNLVPFQLSKFRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG6</accession>
    <name>A0A1U9NIG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AP-4-A phosphorylase</fullName>
            <ecNumber evidence="5">2.7.7.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.53" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00763"/>
    <dbReference type="EnsemblBacteria" id="AQT67615">
        <property type="protein sequence ID" value="AQT67615"/>
        <property type="gene ID" value="STSP2_00763"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00763"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="19543" checksum="7BE4BA14037CEF4D" modified="2017-06-07" version="1">MERKNLWAPWRMKYIKGLTEEHECFICHHLQDKDNDRQNLVLWRGQHSVVLFNRFPYNNGHMLIAPNRHIPDMNAATDEELFEITKLTREIQNALSDTIHPHGFNVGLNFGRCAGAGLPGHMHAHIVPRWNGDTNFMAVCSDTDVISQDLIELYDLLKQISVEKGYPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH9</accession>
    <name>A0A1U9NIH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiE_1</name>
        <name evidence="4" type="synonym">menG</name>
        <name evidence="6" type="ORF">STSP2_00882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67733">
        <property type="protein sequence ID" value="AQT67733"/>
        <property type="gene ID" value="STSP2_00882"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00882"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27069" checksum="27B8B50E0CFBB5CC" modified="2017-06-07" version="1">MSSGKSKLDIKKLFDDLACRYDLINRVLSAGTDMHWRKKAIEFAAPSAGMRILDMCCGTGDVVFAFDEHLDRKAELVGCDFSEEMISIAKKRTTKKYGGAENAHPRHIEWLVGDCQSTDLDGGSFDIVSCAFGVRNMNDRQAGLREMHRLLKPGGRTCILEFSLPQNFLFRFLGLTYLSVFLPIIGGIFSGRIRAYRYLSRSIRTWDREVDLTAELQQAGFSRTDVHRLGIGMAAVHVAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL0</accession>
    <name>A0A1U9NIL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67772">
        <property type="protein sequence ID" value="AQT67772"/>
        <property type="gene ID" value="STSP2_00921"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00921"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20163" checksum="BBA4481F789AEA8C" modified="2017-06-07" version="1">MRKNTITISVTIAALASFLLMVPIVRQNLRNKKVQSFLSDLAAFNDSIEIHGYEVPPPSDEYSIKIKSGPELDIFRKDLSTVISSHVTKAGPRLFCECDAQHKIDFHSPTHAFELHVKHLPNFKFDQPLDPATIINGCDLVYINRKSSTEGTLKLDRQATAEIVKLIQKTAEEYEVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL2</accession>
    <name>A0A1U9NIL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">corC_1</name>
        <name evidence="10" type="ORF">STSP2_00775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AQT67627">
        <property type="protein sequence ID" value="AQT67627"/>
        <property type="gene ID" value="STSP2_00775"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00775"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="48068" checksum="90B0AC4B08D8B7B8" modified="2017-06-07" version="1">MDDVGWSGLLIALLCGGSLFFSLHVVALRTFSRVRLAESFKARGKEDRFDDFLDNAERYTQACSLYRLACNLGLLILSVTLFPDTPVIAVIVAVIVIGILTIAVPHSWAKYTGEWVLARTWSILKLTTWLLSPIVWLLKLHDQLVKRLAGVPESTIEEMHEEKQEEFLSVVEQGRLEGIVDEEELEMIENVLELNDSTAAEIMTPRTDLIALDIKSDREDVLQTISKAGHSRIPVFEENIDSIIGMVYAKDLLAEVGKEPTEFRLADKIRKAYFVPETKPVRDLLHEFQNQKLHIAVVLDEYGGTAGIVTIEDILEELVGEIVDEYEEAQPEPIVELTEDTFEVDARTPIDDLNNECDLDLPEEEDYDTVGGFVLSHLGYIPKAGNTFVYEDLKFQVSDAEARRIRRIKIERMHPQEGKSKQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL8</accession>
    <name>A0A1U9NIL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfatase</fullName>
            <ecNumber evidence="4">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atsA_6</name>
        <name evidence="4" type="ORF">STSP2_00722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67574">
        <property type="protein sequence ID" value="AQT67574"/>
        <property type="gene ID" value="STSP2_00722"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00722"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010698189" evidence="2">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="490" mass="54804" checksum="5DB55AFAEA4BA308" modified="2017-06-07" version="1" precursor="true">MLNRRSFLKLAGVSLASAAVPSLAKAAEAGKPGSSPNIVLIYMDDMGYADPVCYGGKGYSTPNIDRLAKQGMLFTDFHVPQPVCSASRASLLTGCYSNRVSIEGALFPDSKKGLNPEEETIAEILKKRNYKTGMAGKWHLGHHREFLPLQHGFDEYLGLPYSNDMWPVDFNGNPAKSGWKKDCPPLPLIEDNEQVDTIDTLEDQDTLTTRYTERAVKFINENKRRPFFFYLAHTMTHVPLGVSEKFKGKSEQGMYGDVMMEIDWSVGQVMKALENNGLEEDTLVIFTSDNGPWLNFGNHAGSAEPLREGKQTTWEGGCRVSCIMRWPGQIPADSECDKLASTLDILPTIAEITGAPLPEKKIDGVSILSLLKGDENANPRKHLCYFYQRRLCAVREGNWKLVFPHTYQSYEGVEPGMDGHWGPRVKRKAELALYDLKNDIEETEDVKDEHPEVVKHLQKFATKARAELGDRLKNVEGSEVRPPGLHKQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP6</accession>
    <name>A0A1U9NIP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67695">
        <property type="protein sequence ID" value="AQT67695"/>
        <property type="gene ID" value="STSP2_00843"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00843"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6735" checksum="EE58A87CBF3F2030" modified="2017-06-07" version="1">MRRPDKFRRGVMLVWFGVLAWIWLSLGDGQVLYTGLLATLLVYPGVVLIGDAFWPPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT0</accession>
    <name>A0A1U9NIT0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1638 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00648"/>
    <dbReference type="EnsemblBacteria" id="AQT67500">
        <property type="protein sequence ID" value="AQT67500"/>
        <property type="gene ID" value="STSP2_00648"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00648"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012437">
        <property type="entry name" value="DUF1638"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07796">
        <property type="entry name" value="DUF1638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1638" evidence="1">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="28133" checksum="D5802DC013ADBF23" modified="2017-06-07" version="1">MRLKFIVCKVLQREAYWCAARSHNQVDVVLMPQGLHDTPDKLREELGKELVKTEDVQGRKYDASLLGYGLCSNGVLGLSCEIPLVVPRAHDCITLLLGSKERYQEYFDGRKGIYWYSPGWVESNCQPSKSRYDRTLQEYTDKYGEDNAAYLMEMEQNWMKEYEWATYVGWELTDGEQSYKDYTKEAAEFLGWKYDELIGKSLLVQKLVDGDWDKDKFLTVQPGQKVGEDLTSDGIIRAEDNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIY9</accession>
    <name>A0A1U9NIY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="16">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="16">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 21" type="primary">metG</name>
        <name evidence="21" type="ORF">STSP2_00708</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="16"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00708"/>
    <dbReference type="EnsemblBacteria" id="AQT67560">
        <property type="protein sequence ID" value="AQT67560"/>
        <property type="gene ID" value="STSP2_00708"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00708"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16 17" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="20">
        <location>
            <begin position="569"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="16">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="16">
        <location>
            <begin position="327"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AQT67560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="670" mass="76181" checksum="57D1F2D28EF186C6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ02</accession>
    <name>A0A1U9NJ02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR_1</name>
        <name evidence="12" type="ORF">STSP2_01065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01065"/>
    <dbReference type="REBASE" id="191332">
        <property type="entry name" value="PbaBD1IP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67913">
        <property type="protein sequence ID" value="AQT67913"/>
        <property type="gene ID" value="STSP2_01065"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01065"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="309"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1044" mass="119763" checksum="02D1CA6D90D5F7BB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ09</accession>
    <name>A0A1U9NJ09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atsA_8</name>
        <name evidence="7" type="ORF">STSP2_00728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00728"/>
    <dbReference type="EnsemblBacteria" id="AQT67580">
        <property type="protein sequence ID" value="AQT67580"/>
        <property type="gene ID" value="STSP2_00728"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00728"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="387"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="494" mass="55306" checksum="0A8A58D3DB55BAF4" modified="2017-06-07" version="1">MLNRRSFLKGVGVGVGASLLGGDLLLAGEEPKRRKPNFVFIFIDDMGWKDYGAGGSTFYETPNLDRLASEGMRFTDAYAASPVCSPTRAALMSGKHPARLHITDWIPGNRSRKKLDQMDFEQQLPLGEVTIAESLKEAGYRTTYVGKWHLGGEQYWPEKQGFDVNIAGNHKGGPNTRGKYNGYFSPYGLKNLEDGPEGEYLPNRLADEAMQFMEENKDEPFYVQLSHYTVHSPVQAKPELLGKYREKKEQMDTPDGPKFVKEGPDARNREWQDNPAFATMIEAMDANVGRVLGKIDELGIADDTIVIFCSDNGGQSILFANWGPPWGSNRPLRAGKGWCYEGGIRVPMVVKWPGVTKAGSVCSEPVITMDFYPTMLEMAGLELKPEQHVDGLSLVGLLKGGESLGREALHWHYPHYHGSGHRPSGAIRVGKWKLIEFFEDMRVELYDLEKDPGEHNDLSGKMPEKTATVRKMLHQWREEVGADMPEPNPAWKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ31</accession>
    <name>A0A1U9NJ31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00946</name>
        <name evidence="5" type="ORF">STSP2_02352</name>
        <name evidence="6" type="ORF">STSP2_02362</name>
        <name evidence="7" type="ORF">STSP2_03513</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67797">
        <property type="protein sequence ID" value="AQT67797"/>
        <property type="gene ID" value="STSP2_00946"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69165">
        <property type="protein sequence ID" value="AQT69165"/>
        <property type="gene ID" value="STSP2_02352"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69175">
        <property type="protein sequence ID" value="AQT69175"/>
        <property type="gene ID" value="STSP2_02362"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70307">
        <property type="protein sequence ID" value="AQT70307"/>
        <property type="gene ID" value="STSP2_03513"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00946"/>
    <dbReference type="KEGG" id="alus:STSP2_02352"/>
    <dbReference type="KEGG" id="alus:STSP2_02362"/>
    <dbReference type="KEGG" id="alus:STSP2_03513"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="155"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="403" mass="46787" checksum="AFC7DD77A7BF1320" modified="2017-06-07" version="1">MTGQHLIKKLGQWEGYRVGTVGPAKKGREFWVELIPENGFGTCDGCGQECSSVHETVQRWIRDLPVFDKTTHLLVHRRRLLCPRCGPKLERISWLDRYSRHTTRLVESVARLCDVMSIKHVSEYFSLSWSTVKDIHKRHLKKKLGPVDLSNVELLAMDEFAIQKGHRYATVIIDPTCKKVLWVGRGRSRASIRPFFEMLGDRCKDIKAVAMDMNASFEQEVQLHCPQAEIVYDLFHVVAKYGREVIDRVRVDQANRLRDDKPARRVIKGSRWLLLRNRENIEKPEDLVRLDELLAANESLMTTYVMKDDLKLLWNLSDRKAAESCWGQWLDRAMQSGIEPLMKFAKRLSKYAAGIIAHSRWPLHTSLLEGINNKIKTIKRQAYGYRDDEYFFLRIRAAFPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ50</accession>
    <name>A0A1U9NJ50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00997"/>
    <dbReference type="EnsemblBacteria" id="AQT67845">
        <property type="protein sequence ID" value="AQT67845"/>
        <property type="gene ID" value="STSP2_00997"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00997"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="71"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="26932" checksum="A91F7AFCE77D3A30" modified="2017-06-07" version="1">MTLSYYPTMINKYKKRSKISEAKFRQIVKLFALDIEASKIAELTGLSRKTINTILYKIRIRIAEYCQQQSPFDVGEIEIDESYFGARRVRGVRGRGAKGKHIVFGLIKRGGKVYTQVVKNCSKSTLMPIIKQKVNKDSTVYTDGFKTYDGLVDFGYKKHYRVKHGENEFAEGRNHINGIENFWAIAKGRLNKFRGISKGTFALHLKECEFRFNHRHDDLYKLLLKILRKNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ52</accession>
    <name>A0A1U9NJ52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">strE_1</name>
        <name evidence="8" type="ORF">STSP2_00913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67764">
        <property type="protein sequence ID" value="AQT67764"/>
        <property type="gene ID" value="STSP2_00913"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00913"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36739" checksum="21B5CA11C4478DA9" modified="2017-06-07" version="1">MKALITGGAGFIGSHLAEKLVQQQHSVTVVDDLSTGRAQNLAKLHAGPDFEFVKANACDADLMAPLIESCDIVFHLAAAVGVKLIVEKPVHTIQTNIHGTETILDLASKHRKKVLITSTSEVYGKSEKVPFREEDDTVLGSTMFSRWSYACSKAIDEFLALAYHDQFGLEVIITRLFNTIGPRQVGQYGMVVPRFVQAALANEPINIYGTGKQTRCFTYVGDVVDALIALVTTEGTEGRVYNIGSTEEVTIEELANMIIARTNSSSRKNYIPYQKAYGRPFDDMLRRVPSLERIRRTIGYQPDTDLNQTLDSVIKWCKANPLPGNPNDLSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF7</accession>
    <name>A0A1U9NJF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67955">
        <property type="protein sequence ID" value="AQT67955"/>
        <property type="gene ID" value="STSP2_01107"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01107"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="574" mass="61580" checksum="C86EBEB34D0E6613" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJL3</accession>
    <name>A0A1U9NJL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01266"/>
    <dbReference type="EnsemblBacteria" id="AQT68111">
        <property type="protein sequence ID" value="AQT68111"/>
        <property type="gene ID" value="STSP2_01266"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01266"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fucosidase_C" evidence="6">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="468" mass="54396" checksum="F312B3F9984B9B89" modified="2017-06-07" version="1">MADQIFQGQEHPFQKSDYIAPEDPLVEANLERWQDLKFGLMMHWGLYSQLGIVESWGLCSEDQPFQDRGGMPYTEYKKMYFELISEFNPQNFDPAPWARAARYAGMKYMIFTTKHHDGFSMFDTKQTDFKITSPRSPFHTNPKANVAGEIFRKFAEEGFINGVYFSKPDWHHPCYWSPLWATPNRCNNYDTRKYPQMWKEFCNFTYNQIEELMTGYGKIDILWLDGGWVRPNSTINDEVRSWGYDIPQWEQDIDMASIVKMARAHQPDLIVVDRTVQGPYENYRTPEQTVPNEVLGFPWESCITMTQSWGHNFAPEYKSSRFLIHTLVNVTAKGGNLLLNVAPTPDGTFEQEAYDRLSEIGDWMAINGEAIYNSRPEEPYKRDDIYYTQNRRTGDIYAIGLLNEDDSMPNEVHLRILKNIEVANVSLLGTSKPLRSCKENGGISVEIPAELRDERQFKYAWAIKLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJM7</accession>
    <name>A0A1U9NJM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage major tail protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67948">
        <property type="protein sequence ID" value="AQT67948"/>
        <property type="gene ID" value="STSP2_01100"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01100"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011855">
        <property type="entry name" value="Phgtail_TP901_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06199">
        <property type="entry name" value="Phage_tail_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15268" checksum="47D9B4B2066E1573" modified="2017-06-07" version="1">MADFILGMNAKLYQGDAGADVATMTENSNVKDVTLSLEAGEADISTRGNSGWRATAPTLRECNCEFEMVWRPGDAQFDAIKTAFLSSGTVGMAVLTGDSTVTGSEGPAGDWSITNFSRNEPLEEAVTVSVTAKLAKFTEWFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP9</accession>
    <name>A0A1U9NJP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01122"/>
    <dbReference type="EnsemblBacteria" id="AQT67968">
        <property type="protein sequence ID" value="AQT67968"/>
        <property type="gene ID" value="STSP2_01122"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01122"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="35"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="32009" checksum="AB1D9A67E8E7C9BA" modified="2017-06-07" version="1">MAQRVIDLCKRGAEQNNKAKYRQGNVILLPEAAEVVVTGDLHGHRRNFERITQYADLETNHNRHIIFQEILHGGPEDECGGCLSFRVFADIIEYQLRYPDRVHLIMGNHDTAIINDRDVLKNGKEMNRALTGAMQRCFGDQYEEVSTALDEYLFSQPLAVKSPNGVWISHSLPKDRFVDDFDPSIFERPLTSEDLHRPNSVYLLTWGRRHSESTLQTLAEMLGVDIFILGHQAQDSGWCKAGKNLIILASDHDRGCMLKFETDKTYTANELAEAIIPLASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJW4</accession>
    <name>A0A1U9NJW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_13</name>
        <name evidence="5" type="ORF">STSP2_01354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68199">
        <property type="protein sequence ID" value="AQT68199"/>
        <property type="gene ID" value="STSP2_01354"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01354"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="479" mass="54076" checksum="C87270D396FE0249" modified="2017-06-07" version="1" precursor="true">MNRREFLKNAAFAASVAAAPGLTKSASAKPAKKPNVIYILADDLGYRELGCYGQEKIRTPYIDKLAEQGMKFTNHYCGQAVCAPSRCALMTGKHMGHAYVRNNRPVGGGYQLPLPEGTTTIGTLFQKHGYKTGAMGKWGLGGPDSVGRPNNQGFDHFFGNIGQVQAHWYYPPYMYRNTTKIEYPENKKHTGNKYSHDLMEKEALDFIKDNKDNPFFLYLPFIIPHVSLQVPDDEILQSYLDKGWEEKPYKGGHYTGSDTPKAVYAAMITRMDRSVGRVMSLLSELGLEDDTLIMFSSDNGTTYCCGVDYEFFNSVGDFRGLKGSLYEGGIRVPMIAKWPGRIKPGTTTDHISAFWDVLPTMCDVLNADKPADTDGISFMPILLGKPEHQKPHEYLYWEFPSYGFQQAVRMGDWKGYRRNLKKDPDPKLQLYNLKTDPSEQNDVADQHPEVVKNIETIMKEAHTPSEKFPLLHEEFQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX2</accession>
    <name>A0A1U9NJX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67806">
        <property type="protein sequence ID" value="AQT67806"/>
        <property type="gene ID" value="STSP2_00956"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00956"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19708" checksum="5D9998CAA899EA52" modified="2017-06-07" version="1">MKFELNAGDVCVSLYECDSRSELEERLRRVDGVVLLDEEQSGSRFVLVEVQRCGGEEVRAWGMDIVEHGPSPQMVVHGEECLRWVAFGSSLWLVDVWEARVVKYNRLDCVFWDIVRMDSGAAAVVHELGVTAYDAAGERLWDVSGSDMLAGFEVEDERILCRFDDGTSAERKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX3</accession>
    <name>A0A1U9NJX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannosylglycerate hydrolase</fullName>
            <ecNumber evidence="6">3.2.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mngB_1</name>
        <name evidence="6" type="ORF">STSP2_01262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.170" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01262"/>
    <dbReference type="EnsemblBacteria" id="AQT68107">
        <property type="protein sequence ID" value="AQT68107"/>
        <property type="gene ID" value="STSP2_01262"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01262"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="522"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119325" checksum="73FB3A85600563E6" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX7</accession>
    <name>A0A1U9NJX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppdK</name>
        <name evidence="14" type="ORF">STSP2_01202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01202"/>
    <dbReference type="EnsemblBacteria" id="AQT68048">
        <property type="protein sequence ID" value="AQT68048"/>
        <property type="gene ID" value="STSP2_01202"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01202"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="519"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="860"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT68048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="903" mass="99884" checksum="5C1BE512B913A027" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK58</accession>
    <name>A0A1U9NK58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68323">
        <property type="protein sequence ID" value="AQT68323"/>
        <property type="gene ID" value="STSP2_01482"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01482"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14008" checksum="36C66BB7625304E4" modified="2017-06-07" version="1">MGLLDFIKSNDRANTVLVICARDKEKALAGFTARVLFADDCEEALEILKDIDVDVVVARWSINGHPDGDILIKVRSAIPSLPLIAIVDSMDNGCERAARASGMTAVITEEIHAHQLRYKLTHLINRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK69</accession>
    <name>A0A1U9NK69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase D</fullName>
            <ecNumber evidence="4">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phoD</name>
        <name evidence="4" type="ORF">STSP2_01293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01293"/>
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        <property type="protein sequence ID" value="AQT68138"/>
        <property type="gene ID" value="STSP2_01293"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01293"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012550048" evidence="1">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="139"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="52818" checksum="67C991CA572198E7" modified="2017-06-07" version="1" precursor="true">MRIFCAAAGLFVAVSFCQAQTKSGISLSQGIMAGEVGEESVILQARLTGGGADGLGGMAGVGRFEVSKSEDFEDVVRSEWLEARESCDHIVKACIKGLQRDTEYWYRLRFGADKSDVSVSEVGRFETLGGADAAEPVSFAVVAGMNYNKFHSSERVSGEDKRLGYPGLEAIRSAGPDFFVGTGDNVYFDHPRKPAAKTLEEMRGKYHEQFSQERYKRLFREVPTYWEKDDHDFRYNDCDLTGDRLPSVEDGIYSFREQLPVVCPGDEDAVTYRTYRVTKDLQIWLVEGRDYRSPNDMEDGPGKTLWGAVQLEWLKDTLLASDATFKVLISPTPMIGPDDAYKKDNHCNTGGFRYERDEFFAWLSENGFDSGNFAIVCGDRHWQYHSVDPSGFEEFSCGALVDANSRVGRLPGDKRSTDPEGEIEQPYCMTEPSGGFLLVSVLPSLNETAVKLGFKFYDEKKNVLYEHCKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKB3</accession>
    <name>A0A1U9NKB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbB_1</name>
        <name evidence="2" type="ORF">STSP2_01498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68339">
        <property type="protein sequence ID" value="AQT68339"/>
        <property type="gene ID" value="STSP2_01498"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01498"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="350" mass="39372" checksum="4CE067B1E896829A" modified="2017-06-07" version="1">MKILITGTAGFIGYNLAKKLIARGDEVVGLDSINDYYDVRLKYGRLVETGIAADEIEYNKLVTSSTFSNYSFIQLNLEDRTSLERLFSEQKFDRVCNLAAQAGVRYSLENPHAYVDSNIVGFVNILEACRHNEIEHLAYASSSSVYGLNEQMPFSTSDNIDHPVSLYAASKKSNELMAHTYSHLFGLPTTGLRFFTVYGPWGRPDMALFLFTKAILEGRPIDVFNHGNMKRDFTYIDDIVEGVTRVIDNPPAGNPDWSGSNPDPSTSRAPYKVYNIGNSSPVQLMDFIEAIEKALGTKAEKNMLPIQPGDVPATWANVDDLVQNLGYRPNTPIQEGIDQFVKWYRWFYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF4</accession>
    <name>A0A1U9NKF4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 20" type="primary">uvrB</name>
        <name evidence="20" type="ORF">STSP2_01561</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01561"/>
    <dbReference type="EnsemblBacteria" id="AQT68401">
        <property type="protein sequence ID" value="AQT68401"/>
        <property type="gene ID" value="STSP2_01561"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01561"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="429"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AQT68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="674" mass="76962" checksum="073A18ACF745AA86" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI2</accession>
    <name>A0A1U9NKI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68026">
        <property type="protein sequence ID" value="AQT68026"/>
        <property type="gene ID" value="STSP2_01180"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01180"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="94" mass="11019" checksum="C9795C4E785E884E" modified="2017-06-07" version="1">MVRAESKTEAKRILRSRGYRWCRVWRKGTVPWWSSRSWGAKEGGCDWMHFPLRKVHEDDSTVVYKSYNSIAGNIIGTLFVAMLVPFQLSKFNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK2</accession>
    <name>A0A1U9NKK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cdsA_2</name>
        <name evidence="9" type="ORF">STSP2_01200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01200"/>
    <dbReference type="EnsemblBacteria" id="AQT68046">
        <property type="protein sequence ID" value="AQT68046"/>
        <property type="gene ID" value="STSP2_01200"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01200"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="314" mass="35264" checksum="C7A04354338C3331" modified="2017-06-07" version="1">MTEFINTNMHLLIAFAGIFLVLLIAGTTAAILKHRNPQKDYSNLQQRIKTWWYIAFFFAAALLLGKGFFVIFMAFVSFLAMKEYFSLIPTRRVDRRVLLWAYIAVPVQYCWIHIGWYGMFIIFIPVYMFLLTGLRLVLVGRTDGFLRSAGTIHWGMMATVFSLSHIAGLFLVTTPDHPQVSGQTLVFYLLFLTQINDVAQYIWGKSFGKRKVVPQISPGKTWAGLIGGVATTTVLAVLLAPYLTPMNLIHSIFAGIIIGLAGFFGDITISALKRDLKIKDSGSFLPGHGGILDRIDSLTFTAPLFLHFVRYFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN5</accession>
    <name>A0A1U9NKN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Energy-coupling factor transporter probable substrate-capture protein NikMN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nikMN</name>
        <name evidence="9" type="ORF">STSP2_01656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01656"/>
    <dbReference type="EnsemblBacteria" id="AQT68491">
        <property type="protein sequence ID" value="AQT68491"/>
        <property type="gene ID" value="STSP2_01656"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01656"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="342" mass="35330" checksum="844807C41FC7AE44" modified="2017-06-07" version="1">MHMANELINPAVAGGSAVIAASWLGWICKKARKVIDHDKFALMGLMGAFVFAAQMINFPLPLMPGTSGHLVGAVLLAIVFGPFAGAIIISSVVIVQCLVFQDGGILALGCNVINMALVPSFLGYAIYRSIAGGSSVSQSRVYVGAITASVVSLLAGAVLVVAQAAISGVVLVPVKTFMVTMLGVHTVIGLMEGGITAAVLASILNTRPDVMGFEGVGSARVSHSGLHAGLAVATLLVAGSLSWYASGNPDGLEWSYAERPDQPEFEAMVQNDNETIHAADKLHSDYSLMPDYGPRDASSAATLGLSRAWTSFAGVTGSIATMGVVYVSALLLRKRKGTHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP1</accession>
    <name>A0A1U9NKP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_01668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01668"/>
    <dbReference type="EnsemblBacteria" id="AQT68503">
        <property type="protein sequence ID" value="AQT68503"/>
        <property type="gene ID" value="STSP2_01668"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01668"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010747562" evidence="2">
        <location>
            <begin position="21"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="332"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="3">
        <location>
            <begin position="487"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="701" mass="76592" checksum="4C4626CD834414B1" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS6</accession>
    <name>A0A1U9NKS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stalked cell differentiation-controlling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pleD_2</name>
        <name evidence="2" type="ORF">STSP2_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01575"/>
    <dbReference type="EnsemblBacteria" id="AQT68415">
        <property type="protein sequence ID" value="AQT68415"/>
        <property type="gene ID" value="STSP2_01575"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01575"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="222"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="39432" checksum="6D264B0E48B299BA" modified="2017-06-07" version="1">MEDNRPKQNSHDPLKCSGQVCRLESITPLARKLNCLDMKQIADICVTDMPKLVGARLASLYILDDTSDILHLEKNNHPFLINNIVSLNQKPPSPMVAAVRSKNLILVGDIDDIKKPSSNKISRAFSKNYNTKSCIIAPLICQNRVVGVLNLSDKADGGTFGRADVAAIELFRQLIGASIGNVKLFEKSQRLAQTDGLTGMYNHRTFYETLEAELRRAERYGGQISIIMADIDNLKPINDNYGHRAGDLAISQIARRIRACIRQIDIPARYGGDEFAVILPNTTLSDAERVANRIVSMVKGTPMYWEQNEIPLSISVGVGQYNSRSAPGDVTKATDQAMYAAKQAGKGTVKVFETQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA5</accession>
    <name>A0A1U9NLA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulatory protein CseB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cseB</name>
        <name evidence="6" type="ORF">STSP2_01859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01859"/>
    <dbReference type="EnsemblBacteria" id="AQT68689">
        <property type="protein sequence ID" value="AQT68689"/>
        <property type="gene ID" value="STSP2_01859"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01859"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24742" checksum="E198A374AC9FF1C5" modified="2017-06-07" version="1">MEKILIIDDVLDLLETLSLALEQEGYEVRTAETGGEAMACIRTDTPDLILLDVMLEDISGIDLAARLKGNPETAHIPIIMLTARDTEADIIVGLKMGADDYITKPFSTAVLLARIETILRRAKLTSGGMREILSAGDVKVHLNKRSVRAGGKEIDLTEGEYNILVALMEAGGAVLSREDLKECLGERAKGEKERIVDVHIAAARKKLGEHKDIIKTVHGRGYRIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB3</accession>
    <name>A0A1U9NLB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01689"/>
    <dbReference type="EnsemblBacteria" id="AQT68524">
        <property type="protein sequence ID" value="AQT68524"/>
        <property type="gene ID" value="STSP2_01689"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01689"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="313" mass="35406" checksum="3C81545D6E7C672E" modified="2017-06-07" version="1">MTAERHLRYKVRSGFSLMELLVVIGIIMLLIGVLVPGMHAFSKRAKALKQKAQIHSMEVGLELFKKRHGSLPESKAVQDPATSKWVYGAQHLAEALVGRDERGFDPKSKWHVGDEASIASLYRNDETTDIGRRSLNRRYPPSFPLDDSVAIEVDELYDTYGTGSGTDVVHCSDEEWNSGPVLTDTFDLRRITYGGEKVKVGTPVLYYKANRGSSRHAKDVSGITDPTIFNDWIYNYNDNSGLMPLGHLEATQDLLSNDDYTHKLTAVKFYEMITNPRSREDYYRPYNKDGYILWSAGYDGLFGTKDDVTNFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD5</accession>
    <name>A0A1U9NLD5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68316">
        <property type="protein sequence ID" value="AQT68316"/>
        <property type="gene ID" value="STSP2_01475"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01475"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364410" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30139" checksum="E673CD177B4B2D00" modified="2017-06-07" version="1" precursor="true">MKVSKFVFICVVALICSCQAFANYHVKYDFNNQWTGDYAPGWENTDFAGGEDPTGVMMQFAYAGLQGSGAVRIIATDTPDDSYWWADVNPTNVDEAAMAKQYNPWVSAWYWDEGYNSESGNTEGLHRGGQIFAVPDTQAGSGDWSDTQLGAGINSGDQYYYAYADNGGTTVAGTDTVRSEGWHQLKLQLSSDDGKIHYYIDGQEVGATVRDDYDNLLGFGLSTVFTNPLSEWSYNYPWSVWDDFEYGSSIPEPTTIALLGFGSAIFIRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE5</accession>
    <name>A0A1U9NLE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68390">
        <property type="protein sequence ID" value="AQT68390"/>
        <property type="gene ID" value="STSP2_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01550"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32207" checksum="76A005A7679382A5" modified="2017-06-07" version="1">MNDKQGPHDIVDTTDCFEAISVFKSAKNFLFMIILICLLLTQGVFWLKEVGYIEAAPDDEPEVALLAFADTDPDPLPQPEPEQNSDQAQDDAAQDILKDTPAQIEEKARQAADQLLGETASEDQPTQEGEQVEQGDAAEETQDASEPSENRLSIIKPGKKHIIAAVKIANFILVLASVTYCLLLLMSVKISLAGRMGGLTHISRAFLCSLYFLVFLLPWQTLLPGVVTGTIYAPAELMTGWQNVDDSTGTQILYYLRFVGMWVLVLILLLNAQIRSARWSRTTLRRLGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG1</accession>
    <name>A0A1U9NLG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68771">
        <property type="protein sequence ID" value="AQT68771"/>
        <property type="gene ID" value="STSP2_01943"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01943"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="188"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="398" mass="46569" checksum="C418418921DF1A00" modified="2017-06-07" version="1">MAHTRVSVNRNYYGKVPLDKTGKPIPKNLWAKRRKSSWEVRWYDSEGKRLSKSFKDRKEAYDYARSIQDKVDIGKSDKPRQITLRDFTKEHKKLMKGQVAHSTLKDQMRALDLFKKHVNESILLEKITPRCAESFVSERLSQGLSPATVNKDIRTLKSIFNRAISPRGYLPEGANPFEKIKQRKVADKPVKYVSAEEFSKVFDVANNLWWKTFLSVAYTTAGRKDELLNLTWADINFENNEVSFAPKRETDTLLSWEPKDHESRIVPAPESVMQYLADLQNEADEFSPYVFITSRRLMHILERRSKNKWDENSEIINNMLTRLKRFCRQAKVSEFCFHDLRRSCMTNWAKVLPIHVVQELAGHSKIETTRKYYLSVGTPDREMARKIQEQLLGELTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ6</accession>
    <name>A0A1U9NLJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68440">
        <property type="protein sequence ID" value="AQT68440"/>
        <property type="gene ID" value="STSP2_01604"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01604"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="382" mass="42824" checksum="683686BE4C80BA0E" modified="2017-06-07" version="1">MTYRTDKNQVFAKCDIYGNYIDEVIYSYSGATGSMNFYLHDHLYSPVAIVNKATAEIAERCEYNAYGRTTFYTDKGADGNWLTTDDTKARSSSVGNAYTFTGRRLDTLDNGNLELMYYRHRYYDPQMGRFLQQDPWGMDPAANSTRYFNPRSQYKDSNNVYQYVKSWPVISVDPSGLVHVAFPGGSSGSNETVCSRMPCMETCTSDGGEYLDCWDKCSEAYNKFKDWLDGPHPDFEELNDLPCPCELKICTIPGGFGAGQQYPVPPEGWTVIEQLYYIAYLGKYHPGANWDMRSKGCPSQQCTYDHNGDLITHGTGAGTADAHNATRCSHSGGHKKHDKWPADWAMLLDGDSGKWPSSDGGCFKDYISKRPINNGNGCEQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT6</accession>
    <name>A0A1U9NLT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">etfB_1</name>
        <name evidence="2" type="ORF">STSP2_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01706"/>
    <dbReference type="EnsemblBacteria" id="AQT68540">
        <property type="protein sequence ID" value="AQT68540"/>
        <property type="gene ID" value="STSP2_01706"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01706"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33046" checksum="C7911880C8292433" modified="2017-06-07" version="1">MAYNCVVLVKQVPDTTRITGEAMNPDGTVNRGALPAIFNPEDLNALELALDIKDKFGGKVTAITMGLPTASTVLKEALYRGADEAILVTDRRCAASDTLATSYILSCAVKKLDPDIILCGRQAIDGDTAQVGPQLAEKLGVAQITYVEKLLQLEEDRIAAKRSFGNGWQEVRGKLPVLLTVVEEANEPRVNVAHRMMKYKNAMSKADVEKQIRAENPDMDDEAFNNAVNAEVTKLENKGILIKQWDLDFLAADLQWCGRDGSPTKVHRIQSVVLAAKGAKDVEATDQGITDMVHELIEDNTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLW9</accession>
    <name>A0A1U9NLW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68825">
        <property type="protein sequence ID" value="AQT68825"/>
        <property type="gene ID" value="STSP2_02001"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02001"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="558" mass="62940" checksum="E6F4B4E3BCC34C21" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLY7</accession>
    <name>A0A1U9NLY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">STSP2_02120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02120"/>
    <dbReference type="EnsemblBacteria" id="AQT68943">
        <property type="protein sequence ID" value="AQT68943"/>
        <property type="gene ID" value="STSP2_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02120"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="492" mass="53254" checksum="3CC1D466B37EB50A" modified="2017-06-07" version="1">MANEILNLTCKQLRDQIADGTVKSTKAVEAVFAQIEKAEPKIKAFLRTHKEEAMQKAADIDEKIANGDKVGSLAGVPIAVKDNICTSFSKTTCASKILEDFEAPYDAHVIEQLNAADAIIIGKCNLDEFAMGSSTENSGLQQTVNPWDADRVPGGSSGGSAAAVAGRMAFGSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAYGSSLDQIGPFTRNVEDAALMMNVIAGHDGRDSTSVTEKDAPVPDYTADIDKPIEGLKIGIVPRFNEGASDEVGKAVKASLDTYKSLGAEIVEIDMPYFDYAVATYYVIATAEASSNLARFDGVHYGHRTADPHDYVEVYSKSRDEAFGDEVKRRIMLGTYALSSGYYDAYYLKASKVRNLIRQDYTKAFEKVDCIMMPVSPTTAFKFGEKTDDPMQMYLADIYTIAANLAGVPGISVPCGFDSQNLPVGLQIFTPAFSEERLLRIARMYEKENDHNIVMPPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM36</accession>
    <name>A0A1U9NM36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-reducing hydrogenase subunit HndA</fullName>
            <ecNumber evidence="1">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hndA_2</name>
        <name evidence="1" type="ORF">STSP2_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02151"/>
    <dbReference type="EnsemblBacteria" id="AQT68973">
        <property type="protein sequence ID" value="AQT68973"/>
        <property type="gene ID" value="STSP2_02151"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02151"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9820" checksum="DDF0DFDE25B2C718" modified="2017-06-07" version="1">MFRRKKKLEITICMGSSCFSRGSRDSLEVLQKYLEEEGLEEKVDLRGALCMGNCKKGPNMVVSDEEYENVTPGTVVDIVKHHLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM46</accession>
    <name>A0A1U9NM46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">STSP2_02161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02161"/>
    <dbReference type="EnsemblBacteria" id="AQT68983">
        <property type="protein sequence ID" value="AQT68983"/>
        <property type="gene ID" value="STSP2_02161"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02161"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
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            <begin position="222"/>
            <end position="224"/>
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    <sequence length="605" mass="68716" checksum="C77ABC02F1EA0B47" modified="2017-06-07" version="1"> </sequence>
</entry>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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</entry>
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            <authorList>
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                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="gene ID" value="STSP2_03245"/>
    </dbReference>
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            <end position="250"/>
        </location>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT69788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="276" mass="31698" checksum="EC2AF41413E0D0AB" modified="2017-06-07" version="1">MIGQPRASQRYKPQQQPTNTALTSKIIELAKEHQSYGYRFITAKLRQHGWRVNHKRVQRIWRKEALQVPHRRKGRKTKGNSDNSCSVQKADYKDHVWTYDFVSDQSEDGRSLKFLTVLDEFTRESLTIEVGRSIKSGDVVETLEYLFAVRGVPGFIRSDNGPEFVASAIKKKLGKKNVETLYIEKGQPWENGFIESFNGKFRDEVLNRELFYSVKEAKVIVEQWRMEYNNHRPHSGLDYATPAEFAATCIASASPTAQLQQYTTDEKDNSLTVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG8</accession>
    <name>A0A1U9NMG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013047088" evidence="1">
        <location>
            <begin position="25"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="544" mass="57574" checksum="7A35558DBC400771" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI9</accession>
    <name>A0A1U9NMI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide core heptose(I) kinase RfaP</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfaP_1</name>
        <name evidence="1" type="ORF">STSP2_02125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68948">
        <property type="protein sequence ID" value="AQT68948"/>
        <property type="gene ID" value="STSP2_02125"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02125"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="33146" checksum="28326F2D739108A6" modified="2017-06-07" version="1">MSPQSGLFTQTSPGVFIAGEFLDIFTEAGLTDLDSIFAFEQGKNLVKANLAKHRQRIRFDLAGRTFFMKRYTGTPIKQQVKNWTSHHVRASTAEYDIRPCGQLAKVGVATPKIAAYGFEWGLFSEKRSFVITEQIPQGESLERELPPFCTATHNKTNTRKKREFIARLADFVRRFHATGYRHRDLYLAHIFLGERERLYLIDLHRTFKPWLLGERFRVKDIAQLHYSTPGRHFTATDRMRFYKHYAGIERLTPKDKRFIRRVSTKAARIARHDVKHGREVPYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML5</accession>
    <name>A0A1U9NML5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_16</name>
        <name evidence="6" type="ORF">STSP2_02016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68840">
        <property type="protein sequence ID" value="AQT68840"/>
        <property type="gene ID" value="STSP2_02016"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02016"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012256697" evidence="4">
        <location>
            <begin position="25"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="463" mass="52511" checksum="F53AF67E13DEC1A3" modified="2017-06-07" version="1">MDRRSFIKAAGVTALSLTASRSFAAPQRRKPNIIYILADDLGYGELGCFGQKLIKTPNIDRIAQKGIKFTQHYSGSALCAPSRCTLMTGKHTGHCYVRNNYRLPQEGNIPIPAGEVTVAEIMKKAGYKTACIGKWGLGFPHSEGDPNNQGFDHWFGYNCQRQAHNYYPDHLWRNQQKVMLEGNKGPKQEQYSHDLLTQESLQFIETSKDKPFFLYLPYTIPHTKFQVPDLGQYAEKDWKQKHKIQAAMISRMDADVGKIVDLLQKHGIEDDTLVIFTSDNGPHGAAGTIDKFKSDGGLRSRKGRLYEGGIRVPMVAQWPGMIEPNTTTDHISAFWDFLPTCAELAGTKCPDDIDGVSFAPTLLGKKDKQKEHKYLYWELGRRQAIRKGDLKAIRRIKKDRSKDTVELYNLTEDLTEQNDISKERPELVKEMVAIMENAHKPSTVYPLYPSEKSERPDSVKHMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM3</accession>
    <name>A0A1U9NMM3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">acpP</name>
        <name evidence="11" type="ORF">STSP2_02350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02350"/>
    <dbReference type="EnsemblBacteria" id="AQT69163">
        <property type="protein sequence ID" value="AQT69163"/>
        <property type="gene ID" value="STSP2_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02350"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9482" checksum="56ADF785889D6377" modified="2017-06-07" version="1">MADIDVAQIEAKVIEIVSEQMGVDKSEVTRDTSFINDLNADSLDTVELVMEFEDAFDTSIPDEEAEKIQTVGAAIDYIVKVANENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ5</accession>
    <name>A0A1U9NMQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02056"/>
    <dbReference type="EnsemblBacteria" id="AQT68880">
        <property type="protein sequence ID" value="AQT68880"/>
        <property type="gene ID" value="STSP2_02056"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02056"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20846" checksum="AEF119AEF33FB259" modified="2017-06-07" version="1">MIERALIRADIPVKFSQGFNPRPRLSLPLPRSVGTACERDLACVGLDAAEPDERLIAEDLARELPAGADLLEIEIREGRISPHASAATYVIPAGKLMEDREFVDAVALLEAKLRKGEPVVVIRRSKKGRTVQKDVSQFIARIENRGGEICIETLITDAGSVRVDELLTLLGVDMTRLAGPITRTNVVWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT9</accession>
    <name>A0A1U9NMT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02304"/>
    <dbReference type="EnsemblBacteria" id="AQT69117">
        <property type="protein sequence ID" value="AQT69117"/>
        <property type="gene ID" value="STSP2_02304"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02304"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="472" mass="54418" checksum="5DBDE9C40CC3695B" modified="2017-06-07" version="1" precursor="true">MVTRIMQFSIIAFLMSILMPLGTIQAFESKRPPADERTFVSEAVDKKIEEIKDFIKDPEVAWMFENCYPNTLDTTVDYEVIDGKPDTFIITGDIDAMWLRDSTCQVWPYMPLVDQDPKLRKMIEGLINRQVKCVLLDPYANAFFKDLTRESEWNEDKPELKPGVHERKWEIDSLCYVVRLANEYYQITGDASVFNENWDKAMRLIVKTFKTEQRKDGTTPYRFIRSTSRMTDSPVFQGTGRPIKPVGMICSMFRPSDDATVLPFLIPSNLFAVQSLRQLADIYTNELDDPAFAKECTQLADEVHDAVMKWGTAEHLKFGRIYAYEADGFGNMLFMDDANVPSLISLSYLGFHQRGDAIYERTRNYLVSDYNPWYFKGEAAEGYGSPHTGKESIWPMGIILRALTSNDKQEIAKCLHMLKTTHAGTGFMHESFNKDNPSNYSRSWFAWANTLFGELIMEVYQDYPELLQQSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX6</accession>
    <name>A0A1U9NMX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02460"/>
    <dbReference type="EnsemblBacteria" id="AQT69271">
        <property type="protein sequence ID" value="AQT69271"/>
        <property type="gene ID" value="STSP2_02460"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02460"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="424" mass="44162" checksum="928851402D6CD4B5" modified="2017-06-07" version="1">MSTVVVLASLFGLGMCFSLLGSISVKLMPRLEIDQGKFGTLVSIFMFSCLVASLVMGVAVDSVGYKPIALFGFLMTAGCIFYLANSKSYKLITIPCLLLGFGAMAMNVVGNTLAKHVLFGGQNEAAALNLGNVFFGLGLFVTPIVVSFLFQKTTYEKAVASLGVLIIVPAILVFSATFPDKSPGFAFEQAVQLLGNPAVLVSALVLFCYISLEASFCNWLPMFGKDVIKKDAPSMDATAADASAQRLLSLFAIGMMASRLAASFLASKVTIVKDNPAAFFIVGAALVSGILIVAMINTRKTRTAQVLATLAGIAFAPVFPTVVGVTFGKFSSDVHGSVLGIIFAIGLAGAVIAPKAIGNLSRGSSVQKSLKLLVPVCGVLLLLGLAITAVKNPASDSQGDDMADDVQVEQAIDDAEAELPAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX7</accession>
    <name>A0A1U9NMX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69185">
        <property type="protein sequence ID" value="AQT69185"/>
        <property type="gene ID" value="STSP2_02372"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02372"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="49977" checksum="A384C4171DA418E7" modified="2017-06-07" version="1">MLHDPSHHTPPPVAAEIELADKDIDVLRCLAAEVAEIASLPVHKEKARLWTKLNDLQSERPMVWINEICWNEMNVNDELTLQCEHPWARDQEDQLRKTIYQWKHMPVDMVVNDFLVCPLAIHSTDFGIIENVDIVKTDETSDVVSRHFNIQIKEPEDVDKIKLPKITHNEQATEFSYQAMCKVYEGIMPVKKQGQTHIWFTPWDYLIRWWGIEEAMMDMIMRPEMVHAAVGRMVDAWMVELDQFEEQNLLALDNNNTRVGSGGYGYTSELPGANYDSDYVRPHNMWGCSNAQIFSEVSPDMHWEFAIKHDMRWLERFGMTYYGCCEPLDKKMHILRRIPNLRKISTSPWCNIERMISEVGSDYVISQKPSPAILAETEWNPRQARQSIREVLQKADGKCHVEFIMKDISTVRYEPQRLWEWSQIAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN09</accession>
    <name>A0A1U9NN09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_8</name>
        <name evidence="2" type="ORF">STSP2_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68896">
        <property type="protein sequence ID" value="AQT68896"/>
        <property type="gene ID" value="STSP2_02073"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02073"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
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        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16371" checksum="6148F96026AF6953" modified="2017-06-07" version="1" precursor="true">MYNKKSGFTLVEILIVVVILGILAGIVLPGLGQASEDAHETNLKSNLQTVRMQIQLYKTQHDDLLPGQSTIGGNITQADFKAAILSTDAQGYGPYMHDMPKNMLLNDAAKQDDITIVNSDGAVPTGAEGTGWWLNAANGDFRACDSADHINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN44</accession>
    <name>A0A1U9NN44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69030">
        <property type="protein sequence ID" value="AQT69030"/>
        <property type="gene ID" value="STSP2_02209"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02209"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="155"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="403" mass="46801" checksum="F52CAB84761519ED" modified="2017-06-07" version="1">MTGQHLIKKLGQWEGYRVGTVGPAKKGREFWVELIPENGFGTCDGCGQECSSVHETVQRWIRDLPVFDKTTHLLVHRRRLLCPRCGPKLERISWLDRYSRHTTRLVESVARLCDVMSIKHVAEYFSLSWSTVKDIHKRHLKKKLGPVDLSNVELLAMDEFAIQKGHRYATVIIDPTCKKVLWVGRGRSRASIRPFFEMLGDRCKDIKAVAMDMNASFEQEVKLHCPQAEIVYDLFHVVAKYGREVIDRVRVDQANRLRDDKPARRVIKGSRWLLLRNRENIEKPEDLVRLDELLAANESLMTTYVMKDDLKLLWNLSDRKTAESCWGQWLDRAMQSGIEPLMKFAKRLSKYAAGIIAHSRWPLHTSLLEGINNKIKTIKRQAYGYRDDEYFFLRIRAAFPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN93</accession>
    <name>A0A1U9NN93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69198">
        <property type="protein sequence ID" value="AQT69198"/>
        <property type="gene ID" value="STSP2_02385"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02385"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28244" checksum="77E620CB5BB0ACF4" modified="2017-06-07" version="1">MHSVTLTGMISQPSQSTRKAILYARFSPRRNADQCESIETQFDLCTDYCVNNNYEITAKFSDKALSGSDEDRPGLWSAMDSLKRGYCLVVYRLDRLVRSVYLSDIIERTVKKKGASIISISGEGTWSDNDEDWLVRKILQTLAEYERKVIAARTKAAMLRHQANGKRMSKHPPYGFTVDPLNPGRLIEHETEQQIIQQIITMKESGLSLRAICRELQDSGISCRDKCNWHHSTVQRIIQRIDSSSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN94</accession>
    <name>A0A1U9NN94_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02570"/>
    <dbReference type="EnsemblBacteria" id="AQT69381">
        <property type="protein sequence ID" value="AQT69381"/>
        <property type="gene ID" value="STSP2_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02570"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="207"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="411" mass="46912" checksum="277000EBE341240F" modified="2017-06-07" version="1" precursor="true">MAHKFLLITAFICVLGVWGCVEDADGGTYSSPAQSETTSNPAPSQAQPTISLINSPAEPLASDPNDNSAPPAQTPPEGENDEVKDSGKESDSPDKQSPSEDTDGTESREKGENATEVGNKEGKTGSDETGRDESDAASDKDESDRERAITILNEKLARYLNNCNKLFKTYVDEDGRVDYALLRRKRIDLIEVHRTLNDISNAEYMAYSRDEKICFWINTHNLLTLKLVVDNYPIQPRWYMLTYPDNSIMQIPGGREKVLFEVWSNKTEHTLQEIEERLMKKFGDLRIAFALSYASRGSAFLRNEAFYPKKLDEQLDEQVQKFIDSSRGVVFDVADNEIKLSDVFNRYKQYFANSKYAEIKRYRDRSDFVRSCLNFLLEYADDGERAILLDKDFKVTFIIYDWHLNEQPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNA4</accession>
    <name>A0A1U9NNA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">atpF</name>
        <name evidence="15" type="ORF">STSP2_02580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02580"/>
    <dbReference type="EnsemblBacteria" id="AQT69391">
        <property type="protein sequence ID" value="AQT69391"/>
        <property type="gene ID" value="STSP2_02580"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02580"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527460" description="ATP synthase subunit b" evidence="14">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="69"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23362" checksum="DF53FAD5532AB752" modified="2017-06-07" version="1" precursor="true">MKVRSVCAVLLLWACNACALAAEEAPAHGEGESEAPSIFTGYLGESFWTVLAFFLLLAVLWKIAWKPLLASLTARQEHIKKEISDAEKIRNQANEVLQDYKNKLAKADEEGKKIVVAHTSKAEKQSKEILTKARQEVEQMKEKAAEDIERSRIEAQAQLWDQAGEMVLRLGHEVLGKSLTTDDNSRMIDQAIEKLKSEQTRKEENVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND9</accession>
    <name>A0A1U9NND9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sorbitol-6-phosphate 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.140</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">srlD</name>
        <name evidence="1" type="ORF">STSP2_02437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.140" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02437"/>
    <dbReference type="EnsemblBacteria" id="AQT69248">
        <property type="protein sequence ID" value="AQT69248"/>
        <property type="gene ID" value="STSP2_02437"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02437"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009010">
        <property type="term" value="F:sorbitol-6-phosphate 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30438" checksum="DFA7FC00FC8E8B7B" modified="2017-06-07" version="1">MIDRSQISEETPRTVYSDDLKDKVAIVTGAGSGIGKGLAVGLARAGAKVALVDLDEKAANEASEEINVEMPSADVMPVICNVAEEDSVADAYEKIMAKWDRLDALVNAAGIAPAGPLVDIDVKKWRLALEVNLTGYLLMAQAAARIMIDRERGGNIINISSKSGLQASKNNTPYNATKAGEIHMARGWALELGEYGIRVNSICPGNVFKGSKIWNPEYIKICAAKYKIKPEEVIPFYISRTALKREIIGQDIADSVVFLCSEKARVITGQTLVVDSGQVMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM0</accession>
    <name>A0A1U9NNM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)-translocating NADH-quinone reductase subunit D</fullName>
            <ecNumber evidence="8">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqrD_2</name>
        <name evidence="8" type="ORF">STSP2_02680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02680"/>
    <dbReference type="EnsemblBacteria" id="AQT69489">
        <property type="protein sequence ID" value="AQT69489"/>
        <property type="gene ID" value="STSP2_02680"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02680"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23051" checksum="929622D1550836B5" modified="2017-06-07" version="1">MTNGEQAKTTGGIMVQGLWYNNPVFRQILGICSTLAVTNVVMNTLVMCVSLTLVLTFSALTVSALRKVTPHSIRMMVQTLIIAFYVIIVDVILKGYWPEMSENLGPYVGLIITNCIIMGRCEGFARSNPIWPSIVDGFSNGVGYSMLLLVIATSRELLGMGSILGYPMPYFSTIWDKWTIMVMPPGAFFALACTIWLCRSFKPREEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP51</accession>
    <name>A0A1U9NP51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase YcjS</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjS_2</name>
        <name evidence="3" type="ORF">STSP2_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69514">
        <property type="protein sequence ID" value="AQT69514"/>
        <property type="gene ID" value="STSP2_02705"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02705"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="37316" checksum="C7BE85A3E5B58A46" modified="2017-06-07" version="1">MVKIGIVGLGFMGKMHYGCYSSLDNAKIIAICDIDENRFKNTGETAGNIAGAEGELDLSDKTLYTDFDEMVEKEDLDGISICLPTYLHPEYTKKALKAGLNVLCEKPMALSTELCEEMVAAANDAGKRLQIGQCIRFWPEYVKLKEMIESKEYGELKVLTFQRLALTPTTGWQNWYLDGNKSGGAALDLHIHDSDFVQYVFGMPKAVVTTGMTGPTGDYDHMVTQYRYDDDKVITAEGGWMMQASWGFEMSFNAVFEKATVSFDVTKDPMFRVCPADGDQFTPDVLPGTGYSQEIAHFVNAIAGEDVPEITTSQASKESVRLVLAEKESAKTGSKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP66</accession>
    <name>A0A1U9NP66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69400">
        <property type="protein sequence ID" value="AQT69400"/>
        <property type="gene ID" value="STSP2_02589"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02589"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="38695" checksum="39259E759C0906EB" modified="2017-06-07" version="1">MKSLSKEEKDIILDFYFRCGSQERIDRARDLIASDKRAAELFSKLQETLDPLGHVREEPCPDELAEITVARLKLAASAERTREQVEIEQTEPAAVGSAGRRWWSNITDVAAVAAIVLAVISLGIPSLNRIRQASWEKACQANLAGVGVGLKSYAQDSNGSAPCFGNAAGQNPWWKIGEQTERKNSNTQPVWVLVKKGYVDPENLICPARKEHEPVDVSKQQMAELVDFPARKNLSYSFAFMCEKGAQKALRKQFVLFGDLNPIFESVLQKDPRSGQYIFREVVLNDDLQRAMSRSHGGRGQNLLFGDISVSFNRDRKVNGDDIYTVQGVTDYSGTEVPKSADDIFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP70</accession>
    <name>A0A1U9NP70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_3</name>
        <name evidence="5" type="ORF">STSP2_02907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02907"/>
    <dbReference type="EnsemblBacteria" id="AQT69711">
        <property type="protein sequence ID" value="AQT69711"/>
        <property type="gene ID" value="STSP2_02907"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02907"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26503" checksum="58A6B5C86943881E" modified="2017-06-07" version="1">MTAVMEQNDGALLRLEGIQRIYAMGVERVHALAGVDIDIEPGEYVAIMGPSGSGKSTLMNVLGCLDKPTAGRYELAGKDVSKLSGGELAHIRNTQIGFVFQSFELLPRINAMRNVELPLIYSKKTGFRKRRKLVHEALQRVGLGGRMNHRPNQLSGGEKQRVAIARAIICGPSILLADEPTGNLDTKTSESILELFDKLHGEGQTIIMVTHEEDVAQRSKRIIRMQDGGVMSDELTARGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD2</accession>
    <name>A0A1U9NPD2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">feoB</name>
        <name evidence="13" type="ORF">STSP2_02555</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02555"/>
    <dbReference type="EnsemblBacteria" id="AQT69366">
        <property type="protein sequence ID" value="AQT69366"/>
        <property type="gene ID" value="STSP2_02555"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02555"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="690" mass="76283" checksum="09BBED3919D6E61C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF0</accession>
    <name>A0A1U9NPF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ORF">STSP2_02911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02911"/>
    <dbReference type="EnsemblBacteria" id="AQT69715">
        <property type="protein sequence ID" value="AQT69715"/>
        <property type="gene ID" value="STSP2_02911"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02911"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="22431" checksum="971061143D630749" modified="2017-06-07" version="1">MVNGKKIIGILGAVGSGKSTAARLFGELGCAVIDADRIAHAMLDTEEVKQELAAEFGNGIFDEQGEVDRKSLGDKVFNDPQKVQAINAIIHPRVMEEVETRIADRSRKEEVRAIVLDIPLLAEVGWHERCDSLVFVKCDEKIRRDRTHKRHGGRDIEAKKREKFQISLDKKAKIADYILVNNSEVSALADQVQRVFTGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH9</accession>
    <name>A0A1U9NPH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose metabolism transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR_3</name>
        <name evidence="2" type="ORF">STSP2_03016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69819">
        <property type="protein sequence ID" value="AQT69819"/>
        <property type="gene ID" value="STSP2_03016"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03016"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="388" mass="44039" checksum="1505535751C38380" modified="2017-06-07" version="1">MAKQRAEKKIKHQYIYDVLCQDIIKGVYRPGQSLPTEKELAKRFKASRPTIARAMHELQHEGLIVRRQGQGTFVRQIQKTEKKTLGLLVHWQLWSENHRPDQSTTIFGIMIPEILRVASQFNYSLLLNDIPEGLVDPVERARSVCRRLVDSRVSGVFFTPLELIENSDAINKEIAAIFRDAGIAVVLLDRDITDSYHRSDLDIVGINNEQASLVLTHHLIESGCKKIDFISSSIHTTAINDRIRGYRIALEENGMEFDSNRVHLLESKLLRKSASEDSGHELIRLVREKQVDAFICVNDDTASDVINFFLQNGVRIPEDVRVVGFDDLPTSQNQQVPLTTIRQPIQALALESIRTMLSRIENPEMAARDILVKTELVVRDSCGSKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ8</accession>
    <name>A0A1U9NPJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS-type transporter YhjX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhjX</name>
        <name evidence="7" type="ORF">STSP2_02869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02869"/>
    <dbReference type="EnsemblBacteria" id="AQT69674">
        <property type="protein sequence ID" value="AQT69674"/>
        <property type="gene ID" value="STSP2_02869"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02869"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="408" mass="42193" checksum="830D47EF7CF8FE63" modified="2017-06-07" version="1">MKNRWVVLAAGIVIQIVLGGVYAWSTFTPALVENYGLDNGQCGLIFGLIIAVFTVAMTQAGRVLQKKGPKLTAGIGGLLFLAGYFAASFSGGNFIVLLLSLGVVAGAGIGFGYVCPLSVGMKWFPNNKGLVTGIAVAGFGGGAIAFASGGQAMLDNGYDVLTIFRLIGLVLGGLVFAAAMLLAEPDGEKKAGGEDGEGIKRFVFSRNFGLISLGMFAGTFAGLLVVGNLKSIGLWRGLTAQQAVFAVSLYSVGNAIGRITWGQIHDRFGYRTIVLSLSFMAIVLAALLVPMGANAFVAVACLIGFGFGACFVVYAATVVNEYGTELFAKLYPICFLGYGLAGLVAPGVGGRIYDVTQSYSGAVVLSAVIVVAATGVIGLWLRPGKQLVVESGEVKETDLEPGEDMKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM0</accession>
    <name>A0A1U9NPM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">STSP2_03061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03061"/>
    <dbReference type="EnsemblBacteria" id="AQT69863">
        <property type="protein sequence ID" value="AQT69863"/>
        <property type="gene ID" value="STSP2_03061"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03061"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15170" checksum="DE17DD8C112B18E1" modified="2017-06-07" version="1">MAKEVVGKLKLQAPGGQATPAPPIGPALGQHGVNIGQFVSQFNERTSDMNGMTVPVEINIYNDRSFDFIVKSPPAAVLLKKEAGLAKGSGEPNKDKVGKVTKEQVRKISEMKMKDLNAFDPEHADRIIEGTARSMGIEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ5</accession>
    <name>A0A1U9NPQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69767">
        <property type="protein sequence ID" value="AQT69767"/>
        <property type="gene ID" value="STSP2_02964"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02964"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="22398" checksum="618B6C685153DBF9" modified="2017-06-07" version="1" precursor="true">MLPNNVYKTTPSSRILIGVSSVCLIAFAAYNWIVSPQTVCLKAAQQQYHMLQNSGKKAMVIRAKVSKKEREITDLKDSLEVQSQYFFTTNDAREFFYSVETMLEEAGCSILALTYINTATDKANKKEEGGISPVTQKTAKLRFSGSYAGLMQFLGSLDDMPQEVVVRDILMSVDQLNKGKLECSMKITINILQDREALSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY1</accession>
    <name>A0A1U9NPY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative KHG/KDPG aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eda</name>
        <name evidence="2" type="ORF">STSP2_03193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03193"/>
    <dbReference type="EnsemblBacteria" id="AQT69992">
        <property type="protein sequence ID" value="AQT69992"/>
        <property type="gene ID" value="STSP2_03193"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24167" checksum="DC8669D0D5A0DDA4" modified="2017-06-07" version="1">MARYSRMQTLTLIKQIGLLPLFYHPDSDTAKKIASACLAGGARVIEFTNRGDRAIEPFTELVKHRDTDSPDLVLGVGSVLDAPTAAAYIAAGADFIVAPIFCPETARLCNARKIPYLPGCGSLNEIHTAHQAGVEICKLFPANTVGGPAFVKAARAPMPFTDILPTGGVSPDPENLREWFTAGAAAVGMGSKLVSKQLIAAGDYASLTDTVRKTLETINTIRIELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ08</accession>
    <name>A0A1U9NQ08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69814">
        <property type="protein sequence ID" value="AQT69814"/>
        <property type="gene ID" value="STSP2_03011"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03011"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8319" checksum="ADD3A7A05760EEA2" modified="2017-06-07" version="1">MVKLMGNSIDQVPYKIYAKALSSNSLPSTPTQAPGLNPTVLPGNFAPQHLQANPQHPNCTQDALALNVASFGNCFMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ11</accession>
    <name>A0A1U9NQ11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toluene efflux pump outer membrane protein TtgI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttgI</name>
        <name evidence="4" type="ORF">STSP2_03223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70021">
        <property type="protein sequence ID" value="AQT70021"/>
        <property type="gene ID" value="STSP2_03223"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03223"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="496" mass="53584" checksum="8B53DE53A06CC981" modified="2017-06-07" version="1" precursor="true">MNKLSLLATIILVLVAGCSPVGPDYEKPALTDPDFGDVLAARTPAAEKANPVTAEDIAAWWDSFDDQTLNDLITEALIQSPSMKQAYARIVEARARLGIAEAGLAPRIDLGGSYTRSQASENIAGPGQASRARDIYQTGFDAAWELDVFGGVRRAVQASQASLQSEHENLKAIWVSLAGDVSSTYIELRTLQQRLRVARENLAIQEETLELVESLYESGLSDELAVQQARYNLETTSSTIPTLQSNIEEVANALCVLTGQMPGRLNQKLKEADQIPSPAIKNVTAIPANTLRNRPDVKRAERDLAAQTARIGVATSELYPRFTLGGSIGLESLKSSTLFQSDSSAYGFGPSFSMPIFEAGAIRNNIKAQTAIQEQVMASYENTVLSAAKEVRDALIALANEQRRYDRLASAVESASQAVQIAEDQYKNGLSDFNNVLLAQQSLLSLQENLVISQGTKSNNLVRLYKALGGGLQPLDGYEEGLFSEQKAPAKDDGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ18</accession>
    <name>A0A1U9NQ18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69824">
        <property type="protein sequence ID" value="AQT69824"/>
        <property type="gene ID" value="STSP2_03021"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03021"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="154"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="359" mass="42024" checksum="B1F54247777DDCA9" modified="2017-06-07" version="1">MKEKLWLGVVACLAYCIDKELYHAIDYLKEQVRVLVEQQEKQNKRILLTNRQRMRIAAKAKRLSRKMLDQTTVLFSPDTVMGWYRNLIADKYDGSKHRGKVGRPQVDDEIIALVLELKKQNRRWGYQKITDQIVYLGYRISKSCVRNILVENGFDPEPDLTVRSTWHEFIQSHWEVLAACDFFTVELLVKNRLVRCTVFFVIEIASRKVFFAPVKPQPDGDFMKQMARTLTNCEDGFLKGKTYLIHDRDPLYRTDGFHALLKSSGIEPIRLPAHSPDLNVYAERFVRSVKSECLDYLILSSVEQLEYVLDEYSNYYHHERIHQSLGRIIEPKHQLDETADIRCIERLGGLLKSYHRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ68</accession>
    <name>A0A1U9NQ68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70081">
        <property type="protein sequence ID" value="AQT70081"/>
        <property type="gene ID" value="STSP2_03283"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03283"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843870" evidence="1">
        <location>
            <begin position="30"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="607" mass="68472" checksum="B9ECCCF22C18A5D0" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ99</accession>
    <name>A0A1U9NQ99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreduct_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69790">
        <property type="protein sequence ID" value="AQT69790"/>
        <property type="gene ID" value="STSP2_02987"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02987"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032459">
        <property type="entry name" value="Oxidoreduct_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16490">
        <property type="entry name" value="Oxidoreduct_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013115400" description="Oxidoreduct_C domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreduct_C" evidence="2">
        <location>
            <begin position="179"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="457" mass="51500" checksum="595796C1C8A75407" modified="2017-06-07" version="1" precursor="true">MIQKISMALIGALILMAGCSANSNISQSEDQVSFITLDPGHFHAALVQKTMYEGVSPTVNVYAPEGPDVKDHLKRIEGFNTRTQAPTNWTEKVYTGDDFLQKMIDQKKGNVVVVSGNNSKKTDYIYKSVDAGFNVLADKPMVIIPEKFDLLLEAFDTAEKNDVLLYDIMTERYEITTILQKELSQIEPLFGGLVAGTPDNPAVTKESVHHFFKYVAGNPIKRPGWFFDPEQRGEGLSDVSTHLVDLIQWECFPGQIIDYKSDIKMLDARRWTTSMTKEQFSKVTGLEPYPDYLSQYVEGDKLNVYSNGEMNYVINGVHAKVSVAWNYQAPEGAGDTHYSIMRGNRADLIIRQGEKEGYKPTLYVEAVNGSEIAAQLKKAVQQTLQNKYPGIALEQLTDGKWKVVIPDKYRVGHEAHFAQVTEKYLNFLEQGRMPEWEVPNMIAKYYTTMQALETASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB1</accession>
    <name>A0A1U9NQB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">STSP2_03326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03326"/>
    <dbReference type="EnsemblBacteria" id="AQT70122">
        <property type="protein sequence ID" value="AQT70122"/>
        <property type="gene ID" value="STSP2_03326"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03326"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="159" mass="18015" checksum="0CD5522956DA459E" modified="2017-06-07" version="1">MLMLTGEYEHTVDGKGRLFVTNKLRSQIDSEEYGSDFYLVLGANGILCLYPEKCFKKIALAGAPGTAAPDEAVAFERLSFALASKVELDRQGRLLLGDKIRRRARLSDSITLVGARDHIEVWNTEDWEQYLADNLAQYQQQMMQARKSVLQNESRELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQB4</accession>
    <name>A0A1U9NQB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70121">
        <property type="protein sequence ID" value="AQT70121"/>
        <property type="gene ID" value="STSP2_03325"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03325"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7390" checksum="9E82979F464D3FF3" modified="2017-06-07" version="1">MIAAKSNELEIVRDAISNARNNDEAVQASVSVLAERLERLKKRCNLFADVEFSSDVQRLAENAVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQC2</accession>
    <name>A0A1U9NQC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sensory/regulatory protein RpfC</fullName>
            <ecNumber evidence="15">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rpfC_2</name>
        <name evidence="15" type="ORF">STSP2_03118</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69918">
        <property type="protein sequence ID" value="AQT69918"/>
        <property type="gene ID" value="STSP2_03118"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03118"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="389"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="653"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="832"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="774"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="7">
        <location>
            <position position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="934" mass="104127" checksum="D597C2664A081AC5" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQE5</accession>
    <name>A0A1U9NQE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sufS</name>
        <name evidence="8" type="ORF">STSP2_03356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03356"/>
    <dbReference type="EnsemblBacteria" id="AQT70152">
        <property type="protein sequence ID" value="AQT70152"/>
        <property type="gene ID" value="STSP2_03356"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03356"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="28"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44758" checksum="A25036399B5588CE" modified="2017-06-07" version="1">MNQDFNIEKIRQDFPILSQQVYGKPLAYLDNAATTQKPRSVLDAITDYYTTTNSNIHRGTHALSEKASGAYETARKTVRHFLNADQPEEIIFTSGTTASINLVAGSFTDKFVSPGDEIIISQMEHHSNLVPWQILCKKTGAILKTIPLQDSSALSLNAIEELISDKTKLIAVTYVSNVLGTTNPIKRIVDLAHSHGKPVLVDAAQAVQHMPVDVHELDCDFLAFSGHKIYAGTGIGVLYAKSKWLESIPPWKGGGGMINSVSIRKTFYADPPLKFEAGTPNIAGAISLAAAIDYIQSIGIEKIAAHEAEVLNYMHDKLSSLPGLTIYGSKSNRHGAISFNLEDVDNYDAGLILDKMGVAVRTGTHCAEPLMQHYGITGTIRASIGMYNTKEEVDRLYEGLKKVQAMLQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQF0</accession>
    <name>A0A1U9NQF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP-mannose-dependent alpha-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mgtA</name>
        <name evidence="3" type="ORF">STSP2_03343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70139">
        <property type="protein sequence ID" value="AQT70139"/>
        <property type="gene ID" value="STSP2_03343"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03343"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="423" mass="47333" checksum="27B38BBEF76104EF" modified="2017-06-07" version="1">MMTNTYAPYFGGVDKSIRTFTQCFREKGHQVLIVAPKADQDYKEEGVVRVSAIKNFNDIGFPATLPLPGSLHKHIEKFQPEIVHSHFPFLIGSTAMRIAARYDLPLVFTYHTMYERYIHNVNLTSDRVRQFVITFTKGYANLCDQVIAPSNSVADVLRKRGVKTPITVIPTGVDTDKYAQGDGARFRQQVGLDPDDFVVGHVGRLAEEKNLKFLCQSAKKFLQAKPDAKLLIVGDGPSRKNLESLFDGTDVADRAVFAGMKSDQDLIDSYHAADVFAFSSLTETQGMVLAEAMAAGCPVVALKAPGVNDVLEHGSNGYLLEEDSDCDRFARMLSKYHDLSEDEKGSMRSAARQTAEDYSMNNCSDKMLAEYESVLSHKRRDPEKRERNWTLLLESLKAEWDLFLKYANAAGEMFSSHATVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI9</accession>
    <name>A0A1U9NQI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clan AA aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69776">
        <property type="protein sequence ID" value="AQT69776"/>
        <property type="gene ID" value="STSP2_02973"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211451" evidence="2">
        <location>
            <begin position="31"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="57957" checksum="E0BE5436D28A2D6A" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR2</accession>
    <name>A0A1U9NQR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70074">
        <property type="protein sequence ID" value="AQT70074"/>
        <property type="gene ID" value="STSP2_03276"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03276"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="35230" checksum="8A7C49780978A922" modified="2017-06-07" version="1">MEYDLETLLYIWQNKPRRYLINLRGCSREEKEWLKREVIRLSREGKSAKEIAAVYPMNIVTIQEWIHKAPPSLKMWKKRGRKPLRVINPTNHKRILKDVFLEIYNKQEEDVIFWSYSDIQRLVNEHISGHLEEYKKKKRISTLDRKFRYMPVAKELSRYHVKKVVSELLEPPSLAKIRHVFAQEYREPGGERIRYEPNSSIRWCYITGTYFRYFYERPNSRRGSNLNFWTIYSPRGDMRLASKKHSCDHILQALLSRGKNWIALINGTYIGPEVIAKYARTGKIYFLKPYRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV7</accession>
    <name>A0A1U9NQV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease D</fullName>
            <ecNumber evidence="2">3.1.13.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnd</name>
        <name evidence="2" type="ORF">STSP2_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.5" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03201"/>
    <dbReference type="EnsemblBacteria" id="AQT70000">
        <property type="protein sequence ID" value="AQT70000"/>
        <property type="gene ID" value="STSP2_03201"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03201"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="387" mass="44424" checksum="57712238885B581E" modified="2017-06-07" version="1">MPDVEHTNFTYVDTDEGMAEVLPALERAPSIAIDIEADSLHHYFEKVCLIQITIEEENYIVDPLTDMDLDPFLQVLAHKTLILHDAGYDLRMLKNSFGFETKAPVFDTMLAAQLLGYKRLGLVALIKHFCGVSLSKHGQKSDWSRRPLTPNQLQYASDDTYYLHVLAEKLHNQLEQLGRLEWHDQACKKMVRSATAEKEPPDPDRIWRIKGTSKLDPLRLTLVKHIWHWRNDEARKADRPAFHFMHNKDILKLADWVASHPHASIRKSGLLPDNCRGSRRAALENAVHQALSTPPDQMVAKQKRKKSAPAIPYCQQIIEDLRERTRKKGEQLNLPPQIIASRATLTHIGRDRISDFDRLVEEVGMLPWQADILLPDIKETLAKYPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG12</accession>
    <name>A0A1U9NG12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66869">
        <property type="protein sequence ID" value="AQT66869"/>
        <property type="gene ID" value="STSP2_00007"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00007"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25479" checksum="090D4923ABB5B864" modified="2017-06-07" version="1">MQVLPILIAVLVASGVGTLTGFGTSTLLVPVMVLFYPVPETLLFVGIIHWFGNVWKLVLFREGFRWGLVLSFGVPGLVATAIGAKLVFDIPSVILSRVLGGMIAAYVLYLFVQSSFRVRPTVVTGAVGGALSGFFAGIFGIGGAVRSLFLTAFDLPKAVYIATAGAIALVIDTTRLSVYASEGVRLPSSLLWGLIVFIPGSFAGAKIAQRLVDRIPQKNFRKVVAVFLLLIAVKLIVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG19</accession>
    <name>A0A1U9NG19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66873">
        <property type="protein sequence ID" value="AQT66873"/>
        <property type="gene ID" value="STSP2_00011"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00011"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16236" checksum="284AA692BA73D316" modified="2017-06-07" version="1">MGRNLQRCVAGVVLAGLSVLGGCSKESDDWLIGEWVYDGQATKANLPANIKAAGVPDDVAEELGAELVGKLMSQLEDVRIRFTADEITFFTAEGDKTRDYEVIKRPDANTIVVESPETARLTRSGKYLCIPSTGDVDFKMYFKPVECGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG74</accession>
    <name>A0A1U9NG74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar motor switch protein FliM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00069"/>
    <dbReference type="EnsemblBacteria" id="AQT66931">
        <property type="protein sequence ID" value="AQT66931"/>
        <property type="gene ID" value="STSP2_00069"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00069"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="2">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36904" checksum="99626ADAF0FA425A" modified="2017-06-07" version="1">MTEAMTENMISKDQLKALLAKAKQNLPVEEPDVDAVEYDWTRPHHFSTRHHRRLKEFTDELDIELAEQFMSVYSDEVTVTIPGIEEHFATKLQNIQNNTRGCHYLTFGEEGGAPIGMVILPKRSAVHWAAKILKDAIPENVDEAELSQLEMSLLTDHVKKIISVLSNCFTRHNLPALKSGHELTFEEWPLENITDFEEMSVLEFAVADGEEQTSASFAMLSRSFDSMFDISSEQKNLTAKQIQDLIVGHLNNIPLEMECQLGTASAAVADLMTVEEGDVLVLDQTVDAPVELKIDGSVFYHGKLGQSMNRYAVTITDIVKKPANSIIQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGB9</accession>
    <name>A0A1U9NGB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66973">
        <property type="protein sequence ID" value="AQT66973"/>
        <property type="gene ID" value="STSP2_00111"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00111"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012391823" description="PEP-CTERM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18003" checksum="FEA04E31BB76FE85" modified="2017-06-07" version="1" precursor="true">MRINILLSVMALLAFAGTAAAGPYFDLGPQKADVSLSLDEVPPVAEPLPRADEYVFVPRMAEDPNTTGAVNENSQSTSDTTQTVADLSVPESLFQEFDDADATGEATAGGSNLVPSTGFYPGRGISPASGGTPIYFGGDDDDPFYPVIPEPATIALLGIGMLGMSATRKCKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGC7</accession>
    <name>A0A1U9NGC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66983">
        <property type="protein sequence ID" value="AQT66983"/>
        <property type="gene ID" value="STSP2_00121"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00121"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29748" checksum="685669068F27FA4C" modified="2017-06-07" version="1">MRRQDRPKAFTLIELLVVIAIIALLLSIMMPALGIVKEKAKAVVCQSQVRDWGLAWTLYANDHDGTNLNHESAYFWFYKIAPYFSSSNFADNRGSAEGAMEVLVCPSTKPWSDAGNNSFGWGGYGRADMCWEWRRSADQGDDGSYTQGSYIASNWMMSNTGNANAYENISEAKSDAPILADGGFLRVSPTSEEAETSTELVNLQGDGKGDNLPMSDSIERLLLDRHGMATNVVFADAHAERVDLEDMWSLKWHKSFERVDKLELPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGI8</accession>
    <name>A0A1U9NGI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipopolysaccharide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00188"/>
    <dbReference type="EnsemblBacteria" id="AQT67049">
        <property type="protein sequence ID" value="AQT67049"/>
        <property type="gene ID" value="STSP2_00188"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00188"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="372" mass="41806" checksum="495D39810FE7AEEA" modified="2017-06-07" version="1">MKILDRYVAKNFLIGYFIVAAVLIGLIIVVDLFVNLDEFAEASDAGAATVLSNIFKFYSAQSAIYFRDTAGFITVIAAVFSLGKMTKNNELIAIMASGVSLKRVIAPIILLAIALTGLLVVDQELIIPRLAPTLVRDHDAIAGNESYDVWFMKDSKDSLICTPNYTEADQTMHQPTFILRKETAPGRWQVTGMINAEKAKYDPENSRWELANGRLIKLHGNLEDINFGQRPEPVRYYSSDITPYEIPLRRQESYKQYLSTSQLTALERFGGPNIKDLAELILQKQTRITDPIINFIMLLIALPVLVCRDPKQMKSAILKSFLITTACFITAIACKMIATEVIFNQVKPELWAWLPVMIFLPVAFLQLDSMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ8</accession>
    <name>A0A1U9NGJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsmA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00202"/>
    <dbReference type="EnsemblBacteria" id="AQT67062">
        <property type="protein sequence ID" value="AQT67062"/>
        <property type="gene ID" value="STSP2_00202"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00202"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA_2" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118326" checksum="63D17DC6A3A11AB1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS4</accession>
    <name>A0A1U9NGS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redox-active disulfide protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00282"/>
    <dbReference type="EnsemblBacteria" id="AQT67141">
        <property type="protein sequence ID" value="AQT67141"/>
        <property type="gene ID" value="STSP2_00282"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00282"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005243">
        <property type="entry name" value="Redox_disulphide_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36450">
        <property type="entry name" value="PTHR36450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037031">
        <property type="entry name" value="Redox_disulphide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00412">
        <property type="entry name" value="redox_disulf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8093" checksum="C7579B3F5F2F2DBE" modified="2017-06-07" version="1">MKKIKVLGTGCPKCKKLAENAEAAAKTAGVEYELEKVTKLNDIMAFGVMVTPGLVIDGEVKASGKVPSVDDIVAMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX3</accession>
    <name>A0A1U9NGX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67183">
        <property type="protein sequence ID" value="AQT67183"/>
        <property type="gene ID" value="STSP2_00326"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00326"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19693" checksum="9C32CEF7ECD4AB11" modified="2017-06-07" version="1">MPPPPKTRTAYILHSHKRLVNCFSHLLNASLLICHPWEGRNPESITSTPVRSHRQRSNAPTCHPKPDLGSREQIAKPHPTNNLNSTSKTACNQTNRKRRLSRERPGLAGRISTTTTSPHLPHQNPCTDPLHRTDHQTTFHPRTASQDHPELPFLRLPSPSSLHCVFAQQPEAQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH51</accession>
    <name>A0A1U9NH51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="5">5.4.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kamA_1</name>
        <name evidence="16" type="ORF">STSP2_00237</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine = (3S)-3,6-diaminohexanoate</text>
            <dbReference type="Rhea" id="RHEA:19177"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57434"/>
            <dbReference type="EC" id="5.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00237"/>
    <dbReference type="EnsemblBacteria" id="AQT67097">
        <property type="protein sequence ID" value="AQT67097"/>
        <property type="gene ID" value="STSP2_00237"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00237"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022459">
        <property type="entry name" value="Lysine_aminomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00283">
        <property type="entry name" value="L-lysine_2_3-aminomutase_(LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03820">
        <property type="entry name" value="lys_2_3_AblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="121"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT67097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="435" mass="49803" checksum="188E138284039B12" modified="2017-06-07" version="1">MKALTNRQKEMVNIIDDDACGSNWRDWKWQIRHSVKDLDTFEELLGTKLSDEEREKFKKVTEKFPMSVTPYYMSLIDTEDMHNDPVFKQAFPAMSEMTLQKCEMSDPLSEDKDSPVEGITHRYPDRVLFLVSNVCSMYCRHCTRKRRVGDVDFIPDRTVMRKGIDYIKETPQVRDVLLSGGDPFMLDNDLLDWVLSELHKIEHVEVIRIGTRMPVVLPYRINDGLIDVLKKYPPIWINTHFNHPREITSSSRQALKKLADAGIPLGNQSVLLAGVNDCPRIMKALVHKLVANRVRPYYLYQCDLSEGLSHFRTPVGKGIEIMESLIGHTSGFAVPTYVIDAPGGGGKIPVTPNYLVSWSTNKVVLRNYEGVITTYKEPDSYEPWFCNRECGDCKLTLKLEDASEHKCVGIGKLLSDHDKTISLVPENNSRHERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC8</accession>
    <name>A0A1U9NHC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaC</name>
        <name evidence="13" type="ORF">STSP2_00476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00476"/>
    <dbReference type="EnsemblBacteria" id="AQT67332">
        <property type="protein sequence ID" value="AQT67332"/>
        <property type="gene ID" value="STSP2_00476"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00476"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="453" mass="50818" checksum="2CD0265186D38BF7" modified="2017-06-07" version="1">MAETSVGQNTYMGKRMPESLEAEAAVLGSMVIDSACIGQVVQTVTAENFYHPQHQPIYEALAALYERGGQIDLVLLRDELKKKNKLEEIGGVDYLVKVAESVPSAANFEYYAEIVHEKALLRQLIHASKEIMDKAFEEGEVAEKLNYAEKRVFEVTEKRMTGAALPMKNLLAEAFELIEAREGQRITGLPTGYWELDDLLCGMQHGEMSIIAARPSMGKTSFAMNVAEHIAADNNTPLVMFSLEMGKHQLVERMLCGRARVDAQKVRRGTLSTEETAILTETASELFEAPIFIDDTPGLTPLEMLGKCRRLKAQHDIQAVFIDYLQLMSLGGRVESRQQEVSTISRQLKSLARELDVPVVVLSQLNRAAEGRDGHRPRMSDLRDSGSIEQDADVIMLLHREDYYHRGDPEWEENNTAEIIVAKQRNGPTDTVKLTFNGQYTRFDNQSHADEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG5</accession>
    <name>A0A1U9NHG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">rnfA</name>
        <name evidence="9" type="ORF">STSP2_00507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00507"/>
    <dbReference type="EnsemblBacteria" id="AQT67363">
        <property type="protein sequence ID" value="AQT67363"/>
        <property type="gene ID" value="STSP2_00507"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00507"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21132" checksum="3074FD05F7D4268A" modified="2017-06-07" version="1">MDTLQTLILGFLGVVIVNNLVLTKFLGICPFLGVSGRIDMAFGMGLAVTFVVTLAGTLTWIIDHGLLMRYESLVVLRYVAFILVIASAVQLVEMYVRKFFPPLYQSFGIFLPLITTNCAILGLCLFLNLWAVESLLEAVVLSFGAGIGFTLAICIMAGIRENLLLADVPECMKGAPITLVTAGLLTLAFMGFAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK9</accession>
    <name>A0A1U9NHK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuB</name>
        <name evidence="2" type="ORF">STSP2_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00438"/>
    <dbReference type="EnsemblBacteria" id="AQT67295">
        <property type="protein sequence ID" value="AQT67295"/>
        <property type="gene ID" value="STSP2_00438"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00438"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38785" checksum="2FC1943E508C6CAF" modified="2017-06-07" version="1">MAKYNIAVIPGDGTGPEVTREAVKVAKAAAEKFGFELALTEYDFGATRYLKTGETLSDESLEELGGYDSILLGAIGDPKVAPGILEKGVLLKARFGLDQYINLRPVKLYPGVSCPITGKGPDEIDYTVVRENVGGLYTGTGGFTMKGTQHEVAVQSCVYSRYQVERCLRYAFEYARKYGKKARGKGENNTLALVGKTNVLTYVFDLWERAFNEIGDADYPDVKREYYHVDAVCLYMIQSPEMFDVMVTSNMFGDIVTDLGAITQGGLGIAAGGNINPEGVSMFEPIGGTAPSFTGQNVINPLAAICSGAMMLRSLGEDEAATAIEDAVKWGTANKFKSMAAGEMGYGTDEVGDMIAAKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL3</accession>
    <name>A0A1U9NHL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">STSP2_00567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00567"/>
    <dbReference type="EnsemblBacteria" id="AQT67422">
        <property type="protein sequence ID" value="AQT67422"/>
        <property type="gene ID" value="STSP2_00567"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00567"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21633" checksum="FE09D427D65FCDA7" modified="2017-06-07" version="1">MNQAYTESLNKLIEEFSNLPGIGPKTAERLAFHILKADAKEALGLADAISSVKKNTRHCSVCYNLAEGEKCAICADPKRDHSVICVVEQSKDIINLEKTGLCKWVYHVLGGHIAPLEGIEPTDLTIDALLKRVRSGEVKELVMATNPNMEGDGTALYIGSLVKPLGVKITRLARGLPSGSSIEYSSGSILAEAILGRSNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM9</accession>
    <name>A0A1U9NHM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67315">
        <property type="protein sequence ID" value="AQT67315"/>
        <property type="gene ID" value="STSP2_00458"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00458"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="169" mass="19004" checksum="931D9F89BAA39A15" modified="2017-06-07" version="1">MPSYERIIESLTSLLQPYVPGITSEQVSQLLLVLLIGGVVLIITAIVVQILYLLTLAKALKKCSPANREMPPGLVWLELIPVFNLIWRFFNVINVSDSLGREFRSRNMNEEASPARTSGMLYSIFSCGGVIPLIGSFLVLILAPIFWMIYWVRIRKYSKKLDPPPLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP5</accession>
    <name>A0A1U9NHP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">STSP2_00590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00590"/>
    <dbReference type="EnsemblBacteria" id="AQT67443">
        <property type="protein sequence ID" value="AQT67443"/>
        <property type="gene ID" value="STSP2_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00590"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="PTHR10617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12 14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="513"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="554" mass="59954" checksum="EF264D7C5391EF66" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP8</accession>
    <name>A0A1U9NHP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67297">
        <property type="protein sequence ID" value="AQT67297"/>
        <property type="gene ID" value="STSP2_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00440"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7241" checksum="90EE5D1273A02367" modified="2017-06-07" version="1">MECKKEKNLDFCNCSYPCGTKGVCCDCLHKHLRSKQLPACCFPDEVEKTYDRSFDAFARAWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ4</accession>
    <name>A0A1U9NHQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">ywrD</name>
        <name evidence="5" type="ORF">STSP2_00600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00600"/>
    <dbReference type="EnsemblBacteria" id="AQT67453">
        <property type="protein sequence ID" value="AQT67453"/>
        <property type="gene ID" value="STSP2_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00600"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="563" mass="60893" checksum="3187BBB33A1697DA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS9</accession>
    <name>A0A1U9NHS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67479">
        <property type="protein sequence ID" value="AQT67479"/>
        <property type="gene ID" value="STSP2_00626"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00626"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012278992" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26012" checksum="53DAD19C9685963E" modified="2017-06-07" version="1" precursor="true">MRTIITIPAIIAISFLAGCAATTPTADIPEPNRERIEWCDIWITNANQNDLPRVLMIGDSITRGYFPHVEAQLKETANCARYTTSRDLADPVFYDELTLVLKQYPYAVIHFNNGLHGRPSTEAEYAAAFPRMLETLEKYAPQARLIWATSTPVQPTGAFADFVDRVPARNKIAAEHIAASDKPIAINDLNALITGHPEYFLPDGVHYTNEARKLQAEQVARAITAQLPKHKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHU5</accession>
    <name>A0A1U9NHU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">STSP2_00660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00660"/>
    <dbReference type="EnsemblBacteria" id="AQT67512">
        <property type="protein sequence ID" value="AQT67512"/>
        <property type="gene ID" value="STSP2_00660"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00660"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="218"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="543" mass="58525" checksum="1D9F552AA8E2141D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX5</accession>
    <name>A0A1U9NHX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accB</name>
        <name evidence="7" type="ORF">STSP2_00681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00681"/>
    <dbReference type="EnsemblBacteria" id="AQT67533">
        <property type="protein sequence ID" value="AQT67533"/>
        <property type="gene ID" value="STSP2_00681"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00681"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17586" checksum="216775D8209A08D3" modified="2017-06-07" version="1">MADKKKETDVKKVRELVEMMKENDLVEIEIVDGENKILLKRPQPTQPVVNQVPMPAAPAAPQAPAPQAAAPAPAQAEAAPAQDEGLDEIIAPMVGTFYTAPSPDSDPYVKVGSKVDPDTVVCIVEAMKVMNEIKAETTGTIVEVLRKAGEAVEYGQPLFKVKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI52</accession>
    <name>A0A1U9NI52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67457">
        <property type="protein sequence ID" value="AQT67457"/>
        <property type="gene ID" value="STSP2_00604"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00604"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011962323" evidence="2">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26125" checksum="D49A2B637E2CDBFF" modified="2017-06-07" version="1" precursor="true">MRIFVCLVAAVCLAAAGSASADLVVISGNTSSSADAYVNGGSSDFFSDSATVSPSGGSTSSFATSMGTIDDPGDPGDPGDPGDPGMWTVEGGPMGDAMGDVSLTVGDNSFSLMGNSHAGITTGPGNASASAQITFLFELTEESDLAITAFNDFSNSNFEISASSSLYLRDSANQNIISLTSQYSNLDVTVRLDAGIYSVYGTTSSDADIYTPVSQMMWDASGGFEMDVTATTVPEPATVSMLGLGLLGVLRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA2</accession>
    <name>A0A1U9NIA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00601"/>
    <dbReference type="EnsemblBacteria" id="AQT67454">
        <property type="protein sequence ID" value="AQT67454"/>
        <property type="gene ID" value="STSP2_00601"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00601"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39441" checksum="62887D8B4E578104" modified="2017-06-07" version="1">MDTFVRRAAGSNAEEIFINLAPTPDTELADQLEELYSTAKELLAASNAKVLQERFFGTDSAAQQASTARARLLADFDDGVPPTYLSVPAGIRGEISGIHIHAVTGDCTVTPIEHEGKKVGRICTTLDRKFMTVSGITGDPSTDPATQTQQMLTAAEAILKQNNVDLLAVPRTWMWLGDILDWYDDFNEVRTAFFVERGMIAKGKPSRMPASTGIGIGPAGPCICAMEFTAVLEPAGGLEYLDAGGNQHSAFEYGSAFSRAASALTPAGETIYVSGTASIDESGATTNIDDAPAQIDATIENIQAILRDEGTSENGITFGFVYCKTAEIERQFCEKWSNFDWPAFTMIADVCRHDLLFEIEATAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID8</accession>
    <name>A0A1U9NID8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67585">
        <property type="protein sequence ID" value="AQT67585"/>
        <property type="gene ID" value="STSP2_00733"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00733"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="587" mass="66409" checksum="296355D33F846DF7" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII1</accession>
    <name>A0A1U9NII1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Stage III sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spoIIIE_1</name>
        <name evidence="12" type="ORF">STSP2_00459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00459"/>
    <dbReference type="EnsemblBacteria" id="AQT67316">
        <property type="protein sequence ID" value="AQT67316"/>
        <property type="gene ID" value="STSP2_00459"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00459"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="11">
        <location>
            <begin position="446"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="463"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="834" mass="92258" checksum="A9B315A9EFAF96F1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP9</accession>
    <name>A0A1U9NIP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67470">
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        <property type="gene ID" value="STSP2_00617"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00617"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="100" mass="11088" checksum="F11E94A140B06748" modified="2017-06-07" version="1">MPQKTKAACSIVITIAGWGIFFASLIYRNTAPIQNEFSSLANYAVSFYGIIIASVVQLISFICSICFLQKPACRKTSAITIISTLVFAIYISVAFYHHWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU2</accession>
    <name>A0A1U9NIU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl tripeptidyl peptidase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptpA_1</name>
        <name evidence="5" type="ORF">STSP2_01004</name>
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    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
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    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01004"/>
    <dbReference type="EnsemblBacteria" id="AQT67852">
        <property type="protein sequence ID" value="AQT67852"/>
        <property type="gene ID" value="STSP2_01004"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01004"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05468">
        <property type="entry name" value="pVHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022772">
        <property type="entry name" value="VHL_tumour_suppress_b/a_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="255"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="788"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125705" checksum="CFF43C7348024A21" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ29</accession>
    <name>A0A1U9NJ29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67942">
        <property type="protein sequence ID" value="AQT67942"/>
        <property type="gene ID" value="STSP2_01094"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15820" checksum="B9999073562F816E" modified="2017-06-07" version="1">MSVSIKLADAIVAELNGHQFSKAFTAERKLLPEFSLAQLKDLTVTVVPRSVDTTNASRAMRQYEHQVDVGIQKKLTGKVDDELPGLMTLTEEIAEFFACLALPDVPNAVWAGCHNEPIYSPSHLSEHRTFFSILTLTYKVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ53</accession>
    <name>A0A1U9NJ53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xpsD_1</name>
        <name evidence="3" type="ORF">STSP2_00694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00694"/>
    <dbReference type="EnsemblBacteria" id="AQT67546">
        <property type="protein sequence ID" value="AQT67546"/>
        <property type="gene ID" value="STSP2_00694"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00694"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="634" mass="70675" checksum="C6706FA5253B7DBA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ3</accession>
    <name>A0A1U9NJJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01246"/>
    <dbReference type="EnsemblBacteria" id="AQT68091">
        <property type="protein sequence ID" value="AQT68091"/>
        <property type="gene ID" value="STSP2_01246"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01246"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="456" mass="51616" checksum="8CC7F53816FB1E33" modified="2017-06-07" version="1" precursor="true">MILRNIFSNIFLASAVLIIMVSGCTAQNQSPNIVLIISDDQAWTDYGFMGHPVIQTPNLDRLSEEGVLFPRGYVPTPLCRPSLMTMATGLYPHQHGVTGNDPSPKRYTGDAAREANLKLENFIDNYVTIPEALAERGYLSFQSGKWWEGDYQNGGFTHGMTTQGRHGGPGLKIGRQGMDPLYEFVDYAVEQEKPFFVWYAPFLPHTPHNPPQRLLDKYTTEGRDPALAKYYAMCDWFDETCGQVVDYIEQKKIRENTVFVYVCDNGWIQRTADTEVPHGYRQRFAPRSKQTTYEGGIRTPIFFNCPDHFSASKRSEMVSSIDLYPTILAIAGSETPDDRPGLNLLPAVEGGKAIKRDTIFGEGFSHDIADLDNPEKSLLTRWCIEGRWKLILSYDGENERYKAVHKYPGPVQLFDVISDPHETQNLADEYPEVVARLKAKIKAWWPVKEATLISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJR5</accession>
    <name>A0A1U9NJR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67820">
        <property type="protein sequence ID" value="AQT67820"/>
        <property type="gene ID" value="STSP2_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00970"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14719" checksum="E744B3E44C3BC00C" modified="2017-06-07" version="1" precursor="true">MERIRFGKIWRVLVAVALLVVTVEAVSLAAEKAGINLWSWTSSSVHTGTKRDVLVCENIESATACRGEVIEMVWEAVVHDKEWRDRCSLEAKKDGEYMYVNRDFQGLNAKQMEEFHKAWKAVEQIVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU0</accession>
    <name>A0A1U9NJU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01158"/>
    <dbReference type="EnsemblBacteria" id="AQT68004">
        <property type="protein sequence ID" value="AQT68004"/>
        <property type="gene ID" value="STSP2_01158"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01158"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26570" checksum="CA08F76A75A9C69B" modified="2017-06-07" version="1">MGKPTLSSYIRENLDDLGKKTEPGPFVTISRQFGCDGYELGDLLLEKLNILEPDTPWRLFKKEILRDLAEETGLAEEVLEHERMAKPSLIKDFFRGMKRNNIPDGYEIRNKITLMVRTVAFEGHAVIIGQGGTAATADLENGLSVRIEGPRDWRIARVSRRQSLDRKAAVQAIEDVEKQRKTLRKVYEQQNPKEPAFNLTIDNSVFNKEQAVDLIIFALEQKGLIKPEKPAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV2</accession>
    <name>A0A1U9NJV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-rhamnose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rhaA</name>
        <name evidence="4" type="ORF">STSP2_01242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01242"/>
    <dbReference type="EnsemblBacteria" id="AQT68087">
        <property type="protein sequence ID" value="AQT68087"/>
        <property type="gene ID" value="STSP2_01242"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01242"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01748">
        <property type="entry name" value="rhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="422" mass="48064" checksum="07806837F200E277" modified="2017-06-07" version="1">MNQTQIEKAYKLAKERYAAVGVDTEAVLKKLQTIPVSINCWQGDDVGGFEQVGGSELSGGIQTTGNYPGKARTISELRSDIEKALSLIPGQHRLNLHASYLDNGGTFVDRNEIDPGYFQSWIDWAKDRLHGIDFNPTFFSHDKAADGFTLSHPDKSIRDFWIEHAIACRRIASEMGKQLGTPTVTNFWVPDAYKDIPADRVAPRERLADSLDEIFAEEIDPSLNLDAVESKLFGIGGESYTVGSHEFYMGYAISRQKLLCLDAGHYHPTEKISEKISSVMMFCPELLLHVSRPVRWDSDHVVCFDDELQQIAKELIRSDNLDKIHIGLDFFDASINRVAAWVIGTRNLLKALLFALLEPIEQLRRAELNMDYTQRLAYFEELKSMPWNAVWDYYCLKQEIPVGLDWFDEVKQYEKEVMSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK29</accession>
    <name>A0A1U9NK29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase 2 maturation protease</fullName>
            <ecNumber evidence="2">3.4.23.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hybD</name>
        <name evidence="2" type="ORF">STSP2_01451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01451"/>
    <dbReference type="EnsemblBacteria" id="AQT68293">
        <property type="protein sequence ID" value="AQT68293"/>
        <property type="gene ID" value="STSP2_01451"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01451"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18839" checksum="81D6481A902CC784" modified="2017-06-07" version="1">MNTDPFPAILLRLFLSGLTMGKDTIVIGLGNPLMCDEGIGITLIEYLTKKQDEHPDVDFIDAGTGGMQLLHYISGRKKAVLIDCAFMGTEPGTIKRFTADEVKSIKKLSHLSLHEVDILKVIELSEQLGEAPDEVVFFGIEPAAVEDGMELSDTLAGKIDDYLQTIDAELGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK43</accession>
    <name>A0A1U9NK43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01340"/>
    <dbReference type="EnsemblBacteria" id="AQT68185">
        <property type="protein sequence ID" value="AQT68185"/>
        <property type="gene ID" value="STSP2_01340"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01340"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012030186" evidence="1">
        <location>
            <begin position="25"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="658" mass="70624" checksum="DF705227786A2972" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK62</accession>
    <name>A0A1U9NK62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stalked cell differentiation-controlling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pleD_1</name>
        <name evidence="3" type="ORF">STSP2_01124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01124"/>
    <dbReference type="EnsemblBacteria" id="AQT67970">
        <property type="protein sequence ID" value="AQT67970"/>
        <property type="gene ID" value="STSP2_01124"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01124"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="187"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="353" mass="39903" checksum="37511823A64747B5" modified="2017-06-07" version="1">MKTVEDNSTARSSKVLFVGNPLAAFENVEQTLEHDFKRCENMLDAINAAAHQPYETIYVVMSCFTNKLESAIRTLRRVNGSARIVLLARMHEEFQARQLVATPVNRGGVADDYMICPVKVDEVFGEKTAESYERTSAKDADVDRQKDARIRELEKLAIQDDLTNLKNRRYVREFLGQILKKAQELDLWVTLLVFDIDNFKHYNDAYGHSVGDKVLIEAGEVIKNCCREHDVIARIGGDEFAVVFWDRPGDRLGEETVDASGERRRPSKGEHPDNAYQIAERFRRQISATKHEFLGPEGKGVLTISGGLASYPRDGQTVEQLFEQADMAMLEAKRSGKNRVYLVGPEGKYNPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE2</accession>
    <name>A0A1U9NKE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase IV</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dinB_1</name>
        <name evidence="5" type="ORF">STSP2_01363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01363"/>
    <dbReference type="EnsemblBacteria" id="AQT68208">
        <property type="protein sequence ID" value="AQT68208"/>
        <property type="gene ID" value="STSP2_01363"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01363"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025188">
        <property type="entry name" value="DUF4113"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13438">
        <property type="entry name" value="DUF4113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0741">SOS mutagenesis</keyword>
    <keyword evidence="3" id="KW-0742">SOS response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="47209" checksum="21CA32EC53D0227A" modified="2017-06-07" version="1">MSDIFALVDCNNFYASCERVFQPSLKHRPVVVLSNNDGCIVARSNEAKALGIAMGTPYFKAEDIIKKYNVAVFSSNYALYADMSNRVMQTLSRFTSEMEIYSIDEAFLALDGIQGSLDSYGRQIRSTVLQWTGLPVSVGIARTKTLAKIANHLAKKSDKAAGVLDLTQQRYIDHALAKTDVEDVWGVGRRIAAKLRRAGITTARKLAECDIDWVLRTFSIMTVRTVLELRGQKHFGLEEVPEPKKNITVSRSFGKEIETVEQLQQALTQYASRAGEKLRCQNQYAQILTAFAMSNRFDKKNAYYGSASYIFDSATDSSLDLVGAANKLVDEIYRDGVKFKKAGVMLNKLATSKNFQRNLFADREAISRDRRLMQVLDRINERGKQVAFASEGTVKPWQTKFDHRSPCYTTRWDEFVTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE8</accession>
    <name>A0A1U9NKE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagA_1</name>
        <name evidence="3" type="ORF">STSP2_01150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.49" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67996">
        <property type="protein sequence ID" value="AQT67996"/>
        <property type="gene ID" value="STSP2_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01150"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008456">
        <property type="term" value="F:alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012143334" evidence="1">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48757" checksum="5DAE052C438686DC" modified="2017-06-07" version="1" precursor="true">MNGKMDRRSFIKANAGLVAGLSIPGLAGSAFGAAEDNDKPLRIGAVGTGNRCRYLMSVVLGLGGVEIPAVCDIDPKALAAAKKIVTNAGQPEPDGYTEPEDYKKLMDRDDLDAVIIGSPWDLHTPMSVYAMKAGKAVGCEVPIAYTMEECWELIETWEKTGTPCMQLENWSFRSDNLAVLNMIREGVFGTITHAHCAYSHDCIDHWYFERGTGDSRWGAKFLVEHNRAQYPTHQQGPVLSWMDIGCGDWYDTITSTATDQFAIHDYFKRNFPDHPNAKRKYKQGDIVTTVVKTKKGKSIVINFDMQSPRPYDNRWMVQGTRGIYNEQRNALYITGKSPRYHSWEPFPPYHEKYKHEWAKNAFGGHGGADGIMLTQFIKSLREKKPMPLHLYDGVLMAAIGPLSEMSIEKNNQPIEVPDFTRGKWKTRKPYFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKG5</accession>
    <name>A0A1U9NKG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin HigB-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">higB-1</name>
        <name evidence="1" type="ORF">STSP2_01384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68228">
        <property type="protein sequence ID" value="AQT68228"/>
        <property type="gene ID" value="STSP2_01384"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01384"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="104" mass="12306" checksum="66B87036B2797727" modified="2017-06-07" version="1">MEWDFKDKNLIKLYTTGKSPKHRGLPKNVVVNFVARVNEIDAAVDIYDLWKKPALKFEKLKGKKDYCSVRVTGKWRLEFKVDWEDEEHTRGFCWITALSNHYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKH7</accession>
    <name>A0A1U9NKH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosol non-specific dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pepD</name>
        <name evidence="2" type="ORF">STSP2_01465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.18" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01465"/>
    <dbReference type="EnsemblBacteria" id="AQT68307">
        <property type="protein sequence ID" value="AQT68307"/>
        <property type="gene ID" value="STSP2_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01465"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103046">
        <property type="term" value="F:alanylglutamate dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="485" mass="52895" checksum="7F6319F2E16F25ED" modified="2017-06-07" version="1">MKLSDAKAQNVWDIFRRISQIPRPSKHEEQICQWLKDFANKHRFKWQSDHVNNIVIHVPATPGMENSLPVTLQGHVDMVCEKTPDSTHDFSKDPITIIEKDGWATADKTTLGADNGIGVAISLALATDDTVKHPPLELLFTVDEETGLTGAAELQANFIKGRKLINIDTEDEGVFTIGCAGGIQTEIALPVNFVSADPKAVQMTIEIDGLAGGHSGVNIHEQRANAIKLLGRVLSSINDELNINICHLQGGSAHNAIPRNASAMIAFAEDQKYALDKKINDLQTSLANELGPRDSKLKILVHDPSTPSEKTLDTDSTKSTIDLIIALPDGVDRYSFDVEGLVETSNNIATLSTDIEDGMINIMSSQRSCIDSALSRITGRIEATAKLAGANPVTNGKYPGWEPNPDSDLLNISREVYKKVRGKETKIEAIHAGLECGLLGEKFEGMDMISIGATIENPHSPQERVNIESVDHLWNFLKALLPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL1</accession>
    <name>A0A1U9NKL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-reducing hydrogenase subunit HndB</fullName>
            <ecNumber evidence="1">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hndB</name>
        <name evidence="1" type="ORF">STSP2_01432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.12.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01432"/>
    <dbReference type="EnsemblBacteria" id="AQT68274">
        <property type="protein sequence ID" value="AQT68274"/>
        <property type="gene ID" value="STSP2_01432"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01432"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12956" checksum="10DF4B5BE3180AD8" modified="2017-06-07" version="1">MATPLDIVKKKRAQAVSKIISKGYLSTKRVYVGMATCEIAAGSKEVMAVFKDAMAKGLTDVYLSQKGCAGRCNLEPTVEIVEEGKIPVKYGKVDEKKAREIIERHIKNGEIIEEWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS4</accession>
    <name>A0A1U9NKS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Autoinducer 2 sensor kinase/phosphatase LuxQ</fullName>
            <ecNumber evidence="11">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">luxQ_2</name>
        <name evidence="11" type="ORF">STSP2_01345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01345"/>
    <dbReference type="EnsemblBacteria" id="AQT68190">
        <property type="protein sequence ID" value="AQT68190"/>
        <property type="gene ID" value="STSP2_01345"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01345"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <source>
            <dbReference type="EMBL" id="AQT68643.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL58</accession>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53223"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="203"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
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            <position position="115"/>
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            <name>substrate</name>
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            <position position="166"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="241"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="378"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="446" mass="48641" checksum="70CC06854370DA3E" modified="2017-06-07" version="1">MASQFTESIMEITTSRNPAESEFHQAVREVAESVEPVIARHPELARAKVLERMIEPERQVMFRVPWVDDKGNVQVNRGFRVEFNSAIGPYKGGLRFHPSVYLGIIKFLGFEQIFKNALTTTPIGGGKGGSDFDPKGKSDMEVMRFCQSFMSELFRHIGPDTDVPAGDIGVGGREIGYMFGQYKKLTNTFTGVLTGKGLDYGGSLVRTEATGYGLIYFVTEMLKARNTDWNEKKVVISGSGNVAIYATKKAHELGAKVVALSDSGGYIVDESGIKLETVRRIKEVERGRISEYVDEHPNAQYTEGWQGIWTVPCDVALPCATQNELDKSAAEALVKNNCIAVGEGANMPSTPEAVDIFLDNNISFGPAKAANAGGVATSALEMSQNAARLNWTFEEVDNRLKIIMKSIYTQCVEASDEYKMNGNLVAGANIAGFLKVANAMNAQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL63</accession>
    <name>A0A1U9NL63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68468">
        <property type="protein sequence ID" value="AQT68468"/>
        <property type="gene ID" value="STSP2_01632"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Pilin-like"/>
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        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="449" mass="50427" checksum="B689B30FD42E9579" modified="2017-06-07" version="1">MSDKQSKTQGFQLKFRHVVVFLLISAVVLFICFRLSLKRRLNAEYARIRAQGYPVNARELDDFYSIPSDAKNGAEVVEDALIKKVTWSGDKADKLPVSGSVSFDTRTDILKGESLKLVAEYMEENREFLEMLYELRDYNYARYDTDLSRGFAATLEHLSPLKKAAETAMEESIYRTSIGETHNAIRSTETMFALGRTLSKEPTLISYLVKLAIDRMGAASLERTVNMCELDRKQLDRLNALVKSAKNSNVFSRAIAGERAFGMSAFRSQQDMVSVTGMPGPLYLLYAASGLKDKDELLYIDLVSMFLDASKKPFVQRNTAFRKAVRDTKNGVSVWNFGAYIIMPALSKVSDLSLEYLAQLDATKVGLAIEKYRLDKDRLPEKLADLTPTYLDEVPVDPFDGKPMKYLKKGDTNYVVYSIGKDGTDNGGTEPKGGALRSMYDVTFTVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC3</accession>
    <name>A0A1U9NLC3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gndA</name>
        <name evidence="10" type="ORF">STSP2_01793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01793"/>
    <dbReference type="EnsemblBacteria" id="AQT68625">
        <property type="protein sequence ID" value="AQT68625"/>
        <property type="gene ID" value="STSP2_01793"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01793"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="183"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="486" mass="53337" checksum="C16E1F57C3356689" modified="2017-06-07" version="1">MTATAKADIGVVGLAVMGENLILNMESKGFTVSCYNRTVEKVDRFMDGRASGKNIIGARSVEEFVQTLKRPRKVMIMVKAGAPVDKFIEQVLPLLEEGDIIIDGGNSHFPDTIRRTEYVESKGLLYIGTGVSGGEEGALKGPSIMPGGSPAAWEHVKPIFQKISAHTESGEPCCDWVGENGAGHFVKMVHNGIEYGDMQMICETYQMMKEGLGMSNDEMHKVFAEWNEGELDSYLIEITRDILGYKDEDGNYVLDQILDTAGQKGTGKWTAIAALDVGQPLTLIGEAVFARCLSAIKDERVAASKVLSGPDAKFDGDKMQMIEDLKLALYASKIVSYAQGYQLMRAAAAEYGWNLNYGGIALMWRGGCIIRSVFLGKIKEAFDNNPELTNLLLDPFFKGAVENAQAAWRRVVSKAVEMGVPTPAISTALAFYDGYRHDRLPANLLQAQRDYFGAHTYERVDKPRGEFFHTNWTGRGGDTAASTYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD2</accession>
    <name>A0A1U9NLD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnose operon regulatory protein RhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhaS_2</name>
        <name evidence="5" type="ORF">STSP2_01913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01913"/>
    <dbReference type="EnsemblBacteria" id="AQT68741">
        <property type="protein sequence ID" value="AQT68741"/>
        <property type="gene ID" value="STSP2_01913"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01913"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="188"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32925" checksum="3EB0769C363C4399" modified="2017-06-07" version="1">MTDLSGNIRKKFEQVQCLSDRLRQLGWASFTKPVRDRENLPRHVHPDTFEICCIASGNVEWWVEGQIYNAKAGDLFITLPGESHGGLNDIMNPCELYWAQIQLQADTGIGGLKPDELKTLKLELIDAQCRVFTGSAKIEQAFAFLISEHEKPDRFARAKVETTLAQLLIEVARACQAGHANQISPTIQRACDMINAAFNQPIRMEEIARELGLNLSAFYKQFAEQLHEKPTEYLTRLRIAHAKELLRQTDQTITQIAHASGYSSSQYFATIFKRSTGLSPRIYRKNVKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ8</accession>
    <name>A0A1U9NLJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaK_2</name>
        <name evidence="4" type="ORF">STSP2_01877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01877"/>
    <dbReference type="EnsemblBacteria" id="AQT68705">
        <property type="protein sequence ID" value="AQT68705"/>
        <property type="gene ID" value="STSP2_01877"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01877"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="512" mass="55502" checksum="8060AD5186DF673F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK2</accession>
    <name>A0A1U9NLK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68789">
        <property type="protein sequence ID" value="AQT68789"/>
        <property type="gene ID" value="STSP2_01962"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01962"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4147" checksum="35B028BCF91FCFD3" modified="2017-06-07" version="1">MNEYLLQGLLVHAGLADDLTLADALDRIFRKTHLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLS5</accession>
    <name>A0A1U9NLS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68530">
        <property type="protein sequence ID" value="AQT68530"/>
        <property type="gene ID" value="STSP2_01695"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01695"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165671" evidence="2">
        <location>
            <begin position="26"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="790" mass="86463" checksum="62C86C35F2EA474E" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU7</accession>
    <name>A0A1U9NLU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">STSP2_02099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02099"/>
    <dbReference type="EnsemblBacteria" id="AQT68922">
        <property type="protein sequence ID" value="AQT68922"/>
        <property type="gene ID" value="STSP2_02099"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02099"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="617" mass="68557" checksum="21F7338846D1A633" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM13</accession>
    <name>A0A1U9NM13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">acpXL</name>
        <name evidence="7" type="synonym">acpP</name>
        <name evidence="10" type="ORF">STSP2_02013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02013"/>
    <dbReference type="EnsemblBacteria" id="AQT68837">
        <property type="protein sequence ID" value="AQT68837"/>
        <property type="gene ID" value="STSP2_02013"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02013"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14610" checksum="1827B33D2AFAD9C0" modified="2017-06-07" version="1">MAMTRDEIFDEVQEVLVDALGLDDDEVTPEATLMGDLGAESIDFLDIVFRLEKAFGIKIPREELFPAESLMSNPEYVSNGKLTDKGLAELKDKMPHTDLSDFENDPDVNKIADLFTVDSIVNFVELKQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM39</accession>
    <name>A0A1U9NM39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68895">
        <property type="protein sequence ID" value="AQT68895"/>
        <property type="gene ID" value="STSP2_02072"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02072"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15729" checksum="38D50651ED33EB33" modified="2017-06-07" version="1">MMRRNGKGISIPEVLIVGLVICIIGAIVGPAFTKASAEAKLTNLVDRLELVRSQIERYKAEHNGLLPGQLKHGCGIRSDDFVQALTESTSSTMPYLNEMPENPFNGSNEVKIGDGSKGTIGGAGWFFDFKTGEFRADNSRIHAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM57</accession>
    <name>A0A1U9NM57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sporulation kinase E</fullName>
            <ecNumber evidence="10">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kinE</name>
        <name evidence="10" type="ORF">STSP2_02171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02171"/>
    <dbReference type="EnsemblBacteria" id="AQT68993">
        <property type="protein sequence ID" value="AQT68993"/>
        <property type="gene ID" value="STSP2_02171"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02171"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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</entry>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="239"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT68884.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="479" mass="52096" checksum="6D52B295AFE10CE4" modified="2017-06-07" version="1">MKYQNNAQRIKTTLLIETARLAFEGKLQREIDRVPVNLYPRDRTGARCCVYKDRAITKYRLMAIMGHAVETETDELKMLGEYAVDADKREKPADPILTVIDEACSACLKGRHYVTNVCKGCVARPCTVNCPKDAIQVVNGQAIIDDDKCVNCGLCVNVCPYHAIVYVPVPCEEACPVGAIAKGADGREHIDYDKCTFCGKCMQACPFGAIMERSQMVDVIGKLKSDRKVVAMLAPAMAGQFPAEFGKLCAAVRAMGFDNVMEVAEGAAITAEHEANELADRLGDGEQMMTSSCCPAYMETVRKHVPEMAKFVSDTPTPMHYAAKLVKDREPDAVTVFIGPCVAKRHEAMSDELVDYVLTTDELGAMLVGQELDIDEFIAADLGEGPGSEAREFAVTGGVTGAIRAKCGDNRVKAMQVDGIGKKELKMLRRYAKAGCDANFIEVMSCQGGCVAGPCNISKPKAAERRVRKFVEQSKGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ0</accession>
    <name>A0A1U9NMJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB_2</name>
        <name evidence="7" type="ORF">STSP2_02240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02240"/>
    <dbReference type="EnsemblBacteria" id="AQT69055">
        <property type="protein sequence ID" value="AQT69055"/>
        <property type="gene ID" value="STSP2_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02240"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="37901" checksum="B5727FB9BFFA691D" modified="2017-06-07" version="1">MNSVLVTGGAGFIGSNFVRMVLAEHRECKVINLDKLTYAGNLENLAGFMEDSNHEFVRGDICDGLLVERLLEEYSVDAIINFAAESHVDRSIMEPGVFIETNVKGTVALLKAALDKGVGKFVQVSTDEVYGSLGPEGLFTETTPLSPNSPYSASKASADHMVAAFGHTWELDYNITRCSNNYGEYQFPEKMIPLMINNALNDKPLPVYGDGMNVRDWLYVYDHCTAIWQVLTKGRSGDIYNIGGNNEKTNLEVVKRILDRLGKSEDLITFVKDRPGHDRRYAIDSSKIMSELGWKPSVTFEEGIGKAIDWYLENRKWLEHVVSGEYEKYYDQMYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR4</accession>
    <name>A0A1U9NMR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar phosphate isomerase YwlF</fullName>
            <ecNumber evidence="3">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywlF_2</name>
        <name evidence="3" type="ORF">STSP2_02196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02196"/>
    <dbReference type="EnsemblBacteria" id="AQT69018">
        <property type="protein sequence ID" value="AQT69018"/>
        <property type="gene ID" value="STSP2_02196"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02196"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16682" checksum="73E688DCEB4D1E2F" modified="2017-06-07" version="1">MKIAVASDHRGIKAVEQIKATVAELDHEYIDLGCCNDHPVDYPDVAYLAAEAVSSGKVDRAVLVCGTGIGMSIAANKVKGVRAALCFDELNAKISRQHNDANVLCMSGDLLGNTMLRKMVETWLTTEFLGGRHKRRVSKIAAIEEGKDPRTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN00</accession>
    <name>A0A1U9NN00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02364"/>
    <dbReference type="EnsemblBacteria" id="AQT69177">
        <property type="protein sequence ID" value="AQT69177"/>
        <property type="gene ID" value="STSP2_02364"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02364"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012640380" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1648" mass="178668" checksum="9AC855AA7C2E59BE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN07</accession>
    <name>A0A1U9NN07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69293">
        <property type="protein sequence ID" value="AQT69293"/>
        <property type="gene ID" value="STSP2_02482"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02482"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18533" checksum="A5AACAF18B695699" modified="2017-06-07" version="1">MRIGQQGTLTDVWAPKGSRPTAVKQTEYDWVYIFGAVNPVNGKSSAVITPTVNTDYMNHHLRFISEEAGKDVHVVLVLDQAGWHIAKQLVVPKNISLLHLPAYSPELNPIERLWAYMKSHYLSNRIYKNYEEIFNAGTVAWNNITSEMFCSICNTEWIKHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN23</accession>
    <name>A0A1U9NN23_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69342">
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        <property type="gene ID" value="STSP2_02531"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5749" checksum="22823BE24D856C35" modified="2017-06-07" version="1">MSKREIIDFIMELNRGAKPEFLAQFSREELDTYLEHLMEVDLSEMALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE4</accession>
    <name>A0A1U9NNE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
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            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69036">
        <property type="protein sequence ID" value="AQT69036"/>
        <property type="gene ID" value="STSP2_02217"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02217"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="957" mass="108358" checksum="96CD648B0370B31B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG5</accession>
    <name>A0A1U9NNG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfbF</name>
        <name evidence="3" type="ORF">STSP2_02629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02629"/>
    <dbReference type="EnsemblBacteria" id="AQT69439">
        <property type="protein sequence ID" value="AQT69439"/>
        <property type="gene ID" value="STSP2_02629"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02629"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="33401" checksum="77AB1DA91231C505" modified="2017-06-07" version="1">MGHEPTLSAMKVAILAGGLGSRLAEETHLKPKPMVEVGGKPILWHIMRHYSYYGFRKFAIALGYKGDYIKKYMTDYCMMHSDLTVDMHSGSVKVHNGGSLDWLVELVDTGLHTMTGGRIKRLEPLIGNQTFMLTWGDGVSDIDLRKLLAFHRSHGKLATLTAVHPTARFGHLDLDGDSVVEFSEKPQTREGWINGAFFVLEPEIFDYIDGDGTQWEKEPLERLAMDGQLMAYKHTSFWQCMDTLRDKRLLDSLWDSGKAPWKVWESGPAAERRIREISDNSPNQRSKQTYEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNI3</accession>
    <name>A0A1U9NNI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02262"/>
    <dbReference type="EnsemblBacteria" id="AQT69076">
        <property type="protein sequence ID" value="AQT69076"/>
        <property type="gene ID" value="STSP2_02262"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02262"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012617682" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1570" mass="170317" checksum="0D77891F71179081" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK4</accession>
    <name>A0A1U9NNK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69501">
        <property type="protein sequence ID" value="AQT69501"/>
        <property type="gene ID" value="STSP2_02692"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02692"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="784" mass="87895" checksum="A252B1DA9F30D2BF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNP6</accession>
    <name>A0A1U9NNP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">nadE</name>
        <name evidence="10" type="ORF">STSP2_02537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02537"/>
    <dbReference type="EnsemblBacteria" id="AQT69348">
        <property type="protein sequence ID" value="AQT69348"/>
        <property type="gene ID" value="STSP2_02537"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02537"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="549" mass="60871" checksum="4B81C07C14977356" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU7</accession>
    <name>A0A1U9NNU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69515">
        <property type="protein sequence ID" value="AQT69515"/>
        <property type="gene ID" value="STSP2_02706"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02706"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30692" checksum="8BC7C34F68D81705" modified="2017-06-07" version="1">MKIGASYWMFEGGLEAKKPIAEAMQEAKDLGFDSIELAIASEGVLTHETTEQECKDIVATAEKIGIEISSVASGESWGCSPTSNDPAEREKIVEFTKKALQVTKWLGTDAYLFVPGAVHVFFLPEGDVIPYDIAYDRAKEVVAKLVPTAEQVGVTIAIENVWNKFLLSPLEMRDFIDSFDSNRVGCYFDVGNVLLTGYPDQWIKILGDRIARVHIKDYKMVGTAEGFVDMCEGDVDFESVKKALGEIGYDSYLTAEMLPYEPGRPEKTADAMKKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV4</accession>
    <name>A0A1U9NNV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lepB</name>
        <name evidence="7" type="ORF">STSP2_02603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02603"/>
    <dbReference type="EnsemblBacteria" id="AQT69414">
        <property type="protein sequence ID" value="AQT69414"/>
        <property type="gene ID" value="STSP2_02603"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02603"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="102"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="500" mass="56880" checksum="0C107F0DA595D221" modified="2017-06-07" version="1">MGKGFRENQPGSQFEPRYNTTLAGVVNTFEWLLIAVVLAFVFRAFVVEAFRIPTGSMAETLRGDHYHLRCPRCGYEYDLGTDEVSELPHARCPSCAYWASPEVMPAVTNGDRIFVSKAAYQFKEPDRWDVVVFKYPIRPEENYIKRLIAKPGETVELIDGDVYIDGLIRRKPPKVQDELWMPLYINDYQPGGRADRLAAALEDKGPYTNQVWQQPFENVDGSIWNTSVENSAVFSLVSPQSRINTLHYVDRTGHDFEARYAYNSNPIAIRPEVSDLRVVFNVTSASDDGMIGAGLKKNNVLYRGWVDFAGQMIIDRFTGEQREVLVQRDIPGVSVWNGSEFSFEIVDHMVVLRIGENVLKYDAGRQRGDMGVHRRDYKPGVEIYGASNIDISHIEIWRDMYYGSNVLRPRPNEPFTLDEDEYFMAGDNSPISHDSRMWRGPGIGNEGRTYREGIVPRGYLVGKAFFLYWGDAYKPFEGALPIVPNLGKMKPIYGGVDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX8</accession>
    <name>A0A1U9NNX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative stress protein (General stress protein 26)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02807"/>
    <dbReference type="EnsemblBacteria" id="AQT69613">
        <property type="protein sequence ID" value="AQT69613"/>
        <property type="gene ID" value="STSP2_02807"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02807"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16756" checksum="6D787ECC2080AE8B" modified="2017-06-07" version="1">MTPQELTNKLDEIIDHSRTAVLATTDANKQSHMRWMTPAMLKFRPREIFAFSIPGSAKLDHIHTNHNVQWMFQSRDLREIITVEASANIIDNPSIKTELMEIIGHRLGIFWKANVGAEEFVVLETAIKHATYFLPMKGIRQNVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNY3</accession>
    <name>A0A1U9NNY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dapB</name>
        <name evidence="12" type="ORF">STSP2_02748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02748"/>
    <dbReference type="EnsemblBacteria" id="AQT69555">
        <property type="protein sequence ID" value="AQT69555"/>
        <property type="gene ID" value="STSP2_02748"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02748"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="126"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27947" checksum="80098EF0995F7D57" modified="2017-06-07" version="1">MKPKLVVTGAAGRMGKRVLNAAVESGEFEIAAATEADGNPTLGKDAGLTAGIGELGVPITTEGPADADVVIDFSLPQATDKVIDYCVQNNVALILATTGLSDEQLKKVDEVSAKIPIIQQTNMSVGMNTLFAVVGKVANMLGEEYDIEITEAHHRFKRDAPSGSAMTLAENVAKETGRDFPDCLVHGRYGKEAVREKGTIGMHAIRGGDITGEHSVIYSSLGETITISHSAHNRDNFARGSVRAAKWLAGKPAGRYSMADALGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ0</accession>
    <name>A0A1U9NNZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69438">
        <property type="protein sequence ID" value="AQT69438"/>
        <property type="gene ID" value="STSP2_02628"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02628"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17347" checksum="74EC2C448BBAA6D6" modified="2017-06-07" version="1">MNCVEFLENAGAHFSRSERISAFTSQQAVAEKCQIAGIAKAVAQALRIDDEIFLFVYPEDHAIDMDSVRDEFGAESVHRVNQQELLSLEHIKSSSLTPLGSMYGLLTFVDRKIGMQDYLVFSDPETGVDLCMELPEYRRLTHPRMFSFAYSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ6</accession>
    <name>A0A1U9NNZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC_2</name>
        <name evidence="3" type="ORF">STSP2_02708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69517">
        <property type="protein sequence ID" value="AQT69517"/>
        <property type="gene ID" value="STSP2_02708"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02708"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="299" mass="34546" checksum="29D7D04776E88F5E" modified="2017-06-07" version="1">MEQTHKDISNIVRANVQSLPRDIVAQSRYFFYETESTTRQPLEIVCGGYERCGPAFFIDRTDYPFHVIKFTITGKGMFMINGSHHKLEGGVITSFSPGDRHTYRSDPHNPMEHIFVTFTGTRANELLRSSTLSKTKIMQISEPASTLQMLHQILQAGLEKNEYSQQICCNYLEILLLKQASALANTNSPHSLAFDTYRKCKKYIDDNFSAIRTAQQVANSCDVNVRYMSRLFKKHNYISPYEYLTRLKMNKAINLLLHSQMPVSQIGLEVGFEDQFHFSRVFKKYQGLSPQNYRQRHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNZ7</accession>
    <name>A0A1U9NNZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02644"/>
    <dbReference type="EnsemblBacteria" id="AQT69454">
        <property type="protein sequence ID" value="AQT69454"/>
        <property type="gene ID" value="STSP2_02644"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02644"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="457" mass="51769" checksum="B8F23B275203CFEE" modified="2017-06-07" version="1">MSISTLKTDSRIKAKGIQSMLIKRTLGPFRKRRKWLARTQWMTAEQINELQTSLMISLIENIFHNIPFYRSIMDSAGLTPSNFQTLQDIQKMPILNKDTVRNNLDAMINTAVSPAMLHKASTGGTSSHPLPVYRDWRSIGNEHAFVRRQFDWAGLKLNDRCAYLTWRKVSSVNDKNSKYFAYDPAMHELILSTYHLSQETAEQYLHAICRFKVKALVGYPSAIYSLAKFLGHTCRKAQLKAVLTSSEVLDDDIKAAIESRFGCPVFDFYGSAERTCYIHTCEKGSYHIIPEYGITELIPSSKPYEAFYKIVATGFWNNAMPFIRYDTQDMVSVSDNTCTCGRNYPVIDKIIGRESNTVTTRSGRKIGSTAMYRLCKNACSQIAKLPVTDIGVRSTKDGSLTLEYVPADSFSPSDRRKIHNIVVTELPNELSLSTRRVSQLTKTKNGKCLSIIYPVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP98</accession>
    <name>A0A1U9NP98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02925"/>
    <dbReference type="EnsemblBacteria" id="AQT69729">
        <property type="protein sequence ID" value="AQT69729"/>
        <property type="gene ID" value="STSP2_02925"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02925"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="47324" checksum="7873B79B276632A5" modified="2017-06-07" version="1">MIEEKHFGQLWDNLAFTKLFRSFRLAVGPSKLIIAFGVIALVCLFGCAMDLITGSVATQEVKVPTERISQTITELDVYIASPEKIEDFKRANGAYSKGHGVFSTLLSYLADRFNDAFVPLLKLDTSNIFANVVNVFRNIGLAGKAFMWAIRYHPIYSVIFLAFSLVCFCIAGGAICRCAALEFARGEKPGIFEAIRFSFAKFGSLIATPAIPALAMIALGLPILALGLLANIPYGGPILLGIGLPLALIIGLLLTAAMTGSVFGFNLMFPTIAYQGSDSFDAISRSFMYVLTQPLWMIIYSFIAMVYGTLSYLVVRFFSFLLLTVTYNLIRAGIISNGWENGRLSRLWPQPAFADLLGTSPTLPLTLTESISVFFINLTLFFVVGLIAAFVLSFYFCANTIIYVLLRKKVDGTPTDDVYVRLIEANSESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD9</accession>
    <name>A0A1U9NPD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queF</name>
        <name evidence="2" type="ORF">STSP2_02861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02861"/>
    <dbReference type="EnsemblBacteria" id="AQT69667">
        <property type="protein sequence ID" value="AQT69667"/>
        <property type="gene ID" value="STSP2_02861"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02861"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027377">
        <property type="entry name" value="Nitrile_oxidored_QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13712" checksum="50F14609C3D46CBB" modified="2017-06-07" version="1">MSDKPVLEFFDNPRPERDYTITIRCPEFTSVCPKTGHPDFGTITIEYIPEAKCLELKALKYYMQSYRDKGIFYERLTNEILDDLAAGCEPRWMKITASFTPRGGITTDVVAETSAEMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE0</accession>
    <name>A0A1U9NPE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gliding motility-associated ABC transporter permease protein GldF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02900"/>
    <dbReference type="EnsemblBacteria" id="AQT69705">
        <property type="protein sequence ID" value="AQT69705"/>
        <property type="gene ID" value="STSP2_02900"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02900"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26932" checksum="577710A23868FF5B" modified="2017-06-07" version="1">MNGFLSVFKREFKGYFATPLAYVFLVIFLFFSGYMTFRDGFFEIRQADMSIFFRNLPLLFVFMVPSTAMRLWAEERKSGSIELLLTLPITVTQAVLGKFFAAWAFLGIALVLTFPMPVTVAYLGDPDGGLIATGYLASFLLAGGFLSIGMFFSVVSKNQVISFVLSVVACAVLVFAGMPTTLDYLSSFLPGGLVATVEQMSFQGHFESMQRGVLSFKDLSYFALLIVGWIVCSSYMLEERKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH2</accession>
    <name>A0A1U9NPH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CotH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69809">
        <property type="protein sequence ID" value="AQT69809"/>
        <property type="gene ID" value="STSP2_03006"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03006"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="296"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="1421"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1724"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1757" mass="193296" checksum="5FEFBA884A51AFFB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL9</accession>
    <name>A0A1U9NPL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rplS</name>
        <name evidence="5" type="ORF">STSP2_03082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03082"/>
    <dbReference type="EnsemblBacteria" id="AQT69882">
        <property type="protein sequence ID" value="AQT69882"/>
        <property type="gene ID" value="STSP2_03082"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03082"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="122" mass="14113" checksum="9E021760BE50F756" modified="2017-06-07" version="1">MKTEILESVESKSLKQELPHFEVGDTVQVHCKIKEGEKERIQLFSGTVIARNGRGINETFTVRRMIGDEGVERVFPLHSPNVVTVEPMRSSKVRRAKLYFLRERRGKGVRLAQRRSDHTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP4</accession>
    <name>A0A1U9NPP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xpsE_4</name>
        <name evidence="3" type="ORF">STSP2_02773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02773"/>
    <dbReference type="EnsemblBacteria" id="AQT69580">
        <property type="protein sequence ID" value="AQT69580"/>
        <property type="gene ID" value="STSP2_02773"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02773"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="582" mass="65264" checksum="2C43F96A08C27264" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ2</accession>
    <name>A0A1U9NPQ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mutS</name>
        <name evidence="11" type="ORF">STSP2_03093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03093"/>
    <dbReference type="EnsemblBacteria" id="AQT69893">
        <property type="protein sequence ID" value="AQT69893"/>
        <property type="gene ID" value="STSP2_03093"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03093"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="627"/>
            <end position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="871" mass="97541" checksum="AA789213F14ADFA9" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS4</accession>
    <name>A0A1U9NPS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-beta-1,6-N-acetyl-D-glucosamine synthase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgaC</name>
        <name evidence="3" type="ORF">STSP2_02804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02804"/>
    <dbReference type="EnsemblBacteria" id="AQT69610">
        <property type="protein sequence ID" value="AQT69610"/>
        <property type="gene ID" value="STSP2_02804"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02804"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="353" mass="39185" checksum="A9E36E4D03904229" modified="2017-06-07" version="1">MTISIKPSQDHPDVSIVMPCRNEEAHIAQCIQSVLDQDYPADNYELLIVDGMSDDQTRKIVHDNFGNTENIRVIDNPARTTPHALNAGIKNARGQIIMIMGAHAHYASDYVSKCVKSLLSTDADNVGGICRVLCDDKNLLHRSIAAALSSPFGVGNSYFRIGTAERRYVDTVFGGCYRKEIFEKIGLFDTDLLRGQDTEFNARLRKNGGKILLDPQIVSAYVARDTLKKLVKMEWQYGYFKPLVIKKVGGLFTLRQTVPPAFVLTLGILLVTSFFSLLSFYILLSLLLLYLSVNIPASTSIALRKGIGQILFLPVIFAIIHFCWGTGFLAGTIDFILLSKESKEGLTDISLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPT1</accession>
    <name>A0A1U9NPT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69919">
        <property type="protein sequence ID" value="AQT69919"/>
        <property type="gene ID" value="STSP2_03119"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03119"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011460">
        <property type="entry name" value="DUF1566"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07603">
        <property type="entry name" value="DUF1566"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012007531" evidence="2">
        <location>
            <begin position="24"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="473" mass="50335" checksum="8EDF5720C7C915F5" modified="2017-06-07" version="1" precursor="true">MKLFGKFAFFGVVLGFCGGVVFAGGLSSAVVDTGQDVCYDDSYELSVCPGAGDAFYGQDAQYAGDGPSYTDNGEGTVTDNVTALMWAKSSDMDGDGDIDAADKMSYADALAGADSFGLAGYSDWRLPTIKELYSLIDFRGEDPSGYNGTDASGLVPFIDTDYFDFAYGDTSAGERLIDAQFATSTLYVSTTMGGAETMFGVNFADGRIKGYPKGVMPGQTEAKTFYVLYVRGSASYGTNEFADNGDGTVSDAATGLMWAKADSGTGLDWSEALAWAAAKNAENHLGYGDWRLPNVKELQSIVDYTRSPDITGSAAIDTVFECTQITNEAGQADWPCYWSGTTHRNWTQRPGESGAYVAFGRAMGYMRGTWMDVHGAGAQRSDPKAGDPADYPTGHGPQGDAIRIYNYARLVRDMGCGDPGYDSKLAGDLTGDCYVDLEDFAELCRGWTVDYGMAELAEMAGNWLGCVGPGCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV0</accession>
    <name>A0A1U9NPV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA_2</name>
        <name evidence="6" type="synonym">fusA</name>
        <name evidence="8" type="ORF">STSP2_03053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03053"/>
    <dbReference type="EnsemblBacteria" id="AQT69855">
        <property type="protein sequence ID" value="AQT69855"/>
        <property type="gene ID" value="STSP2_03053"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03053"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="693" mass="76220" checksum="3D869BB027A43C26" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPW7</accession>
    <name>A0A1U9NPW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">exo I_5</name>
        <name evidence="9" type="ORF">STSP2_02749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69556">
        <property type="protein sequence ID" value="AQT69556"/>
        <property type="gene ID" value="STSP2_02749"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02749"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211457" description="Beta-N-acetylhexosaminidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="8">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="7">
        <location>
            <begin position="155"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="820" mass="91959" checksum="3CEC0F77FC78F200" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPY5</accession>
    <name>A0A1U9NPY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69885">
        <property type="protein sequence ID" value="AQT69885"/>
        <property type="gene ID" value="STSP2_03085"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5932" checksum="188CBC84CD59194B" modified="2017-06-07" version="1">MMEFENLVMVFVGFFLLVLMLVALFGIKNSFAKIQADIHKIAAKMDQQSGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ40</accession>
    <name>A0A1U9NQ40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.135</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pglF</name>
        <name evidence="4" type="ORF">STSP2_02926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.135" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02926"/>
    <dbReference type="EnsemblBacteria" id="AQT69730">
        <property type="protein sequence ID" value="AQT69730"/>
        <property type="gene ID" value="STSP2_02926"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02926"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="319"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="653" mass="73265" checksum="A568D1F84487BC39" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ76</accession>
    <name>A0A1U9NQ76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69666">
        <property type="protein sequence ID" value="AQT69666"/>
        <property type="gene ID" value="STSP2_02860"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02860"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18436" checksum="E38E9E62EF355F4E" modified="2017-06-07" version="1">MTIGFECESCGKKVKAPDNAGGKKGKCPFCSHQCYVPAGDDAGEELKLEPIEEEEERRQRELDRKAFAIQQGILGETSMGEESGEAEEGYNQRELLRNIILYLREMAGGELNKASERLGEIRKWSEQAKQITASMMRTDQTEAELADISPRVLVGLLKDLRAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH7</accession>
    <name>A0A1U9NQH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I restriction enzyme EcoKI subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03277"/>
    <dbReference type="REBASE" id="191339">
        <property type="entry name" value="PbaBD1ORF3277P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70075">
        <property type="protein sequence ID" value="AQT70075"/>
        <property type="gene ID" value="STSP2_03277"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03277"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="337"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="557"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120906" checksum="A4696CAE643E8ADE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP5</accession>
    <name>A0A1U9NQP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">STSP2_03457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03457"/>
    <dbReference type="EnsemblBacteria" id="AQT70251">
        <property type="protein sequence ID" value="AQT70251"/>
        <property type="gene ID" value="STSP2_03457"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03457"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="377" mass="41687" checksum="09D0FB216765C5F2" modified="2017-06-07" version="1">MAKRDYYDVLGVKKDASADDIKRAYRRLAMKYHPDKNPDDKQAEEKFKECAEAYEVLSNPEKRQRYDQFGHEGLRGTGMHDYSHMNVQDIGDMFGDIFGDFFGGGRRRRTARPNAPTRGYDLETTVELTLSEIAEGAEKSIEFTRQDLCPECQGKGTAKGKKPATCNMCGGGGQVQKAGLGGFFQMVSTCPQCQGKGTVITDPCRKCHGKGQVPKKRVVTVKIPSGVHEGQGIRVTGEGEPGKNGGPRGDLYCYVRVKAHPFLMRDGNDLVATVPISFTQAALGARIDVPSLNGTKHLKVPPGTQHGNVFRIKGEGLPDLRTNRKGDELVKVAVEIPRNLTNEQEKLLREFAESENNDVLPESRGFFDKLKKYFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP7</accession>
    <name>A0A1U9NQP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00653</name>
        <name evidence="4" type="ORF">STSP2_03250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67505">
        <property type="protein sequence ID" value="AQT67505"/>
        <property type="gene ID" value="STSP2_00653"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70048">
        <property type="protein sequence ID" value="AQT70048"/>
        <property type="gene ID" value="STSP2_03250"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00653"/>
    <dbReference type="KEGG" id="alus:STSP2_03250"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="21337" checksum="6AB2AAE3862543BE" modified="2017-06-07" version="1">MNQPASNGPTISFDEFGPLEIRPQPGRNYCHTDHPKRLPATYTRKHGVQHWLAFYDVHQKKLWGYVRPRKRHQEFLEVLKLTRKKYPANQRIHLILDNFSPHRKDKVLRYCRENNIHLIWTPTNASWLNPIECQFTHVKEFVIRGTNYQNHNELKTALNRYVAYRNKKNQQKRNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQQ0</accession>
    <name>A0A1U9NQQ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP_2</name>
        <name evidence="2" type="synonym">clpP</name>
        <name evidence="5" type="ORF">STSP2_03311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 4">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03311"/>
    <dbReference type="EnsemblBacteria" id="AQT70107">
        <property type="protein sequence ID" value="AQT70107"/>
        <property type="gene ID" value="STSP2_03311"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03311"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22131" checksum="E56C9CA605352DEC" modified="2017-06-07" version="1">MEMNQLVPIVIEKTGRGERSYDIYSRLLKDRIVFLGGPVDDNAANLIVAQLLFLSNEDSKSDIHFYINSPGGAITAGLAIYDTMKFLRCDVATYCVGQAASMGAVLFAGGTSGKRYMLKNGRVMLHQPLLSGIMQGPATDLEIEAKEIIRLRERLYQILAEHTGRDAEKIERDCDRNLWLEADEAIEYGLADSVLEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV5</accession>
    <name>A0A1U9NQV5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ORF">STSP2_03410</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03410"/>
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        <property type="gene ID" value="STSP2_03410"/>
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    <dbReference type="UniPathway" id="UPA00219"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-bd_PCMH"/>
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        <property type="entry name" value="MurB_C"/>
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        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AQT70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31980" checksum="E001A52731B3AA36" modified="2017-06-07" version="1">MNIFSGLQEIVKTDSDLSNYTWLGLGGRAEYFVTPRSVEELQTVMVRCRENSLPVHVLGFGSNLLVSDEGVRGAVIKLESDEFTKTEYEGEQLTAWAGVNLSKLVLECVRKGLGGLESLTGIPGSIGGAVRMNAGGNWGDIGACVDSVTLMSREGEIFEKAKPELIFDYRSVNITAPLILNAKMKLVESDSDQLLRTVKEIWIYKKNSQPLNTKNAGCVFKNPRGLSAGALIDRAGLKGLKIGGAQVSEQHANFLVTEKGCKSADVKKLIDIVRNKVQEEFDVQLELELEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW6</accession>
    <name>A0A1U9NQW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">polX</name>
        <name evidence="21" type="ORF">STSP2_03338</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03338"/>
    <dbReference type="EnsemblBacteria" id="AQT70134">
        <property type="protein sequence ID" value="AQT70134"/>
        <property type="gene ID" value="STSP2_03338"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03338"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="21" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="21" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="2"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="341"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AQT70134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="574" mass="64778" checksum="59D7EF1C8F8236FD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQZ0</accession>
    <name>A0A1U9NQZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tuaD_2</name>
        <name evidence="12" type="ORF">STSP2_03548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03548"/>
    <dbReference type="EnsemblBacteria" id="AQT70342">
        <property type="protein sequence ID" value="AQT70342"/>
        <property type="gene ID" value="STSP2_03548"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03548"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="314"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="431" mass="47566" checksum="FE3211A7E107E7A0" modified="2017-06-07" version="1">MKVAAVGVGYVGLVAAACLADAGNDVMCVDNDPQKIDLLRDGEIPIYEPGLTEIVKRNVTAGRLKFTTSIKEGVDESLLIFIGVGTPSAPDGSADISAVLEVAEQVAESMTDYRIIVTKSTVPVGTHKLVSEIMASKTDHPFDYVSNPEFLKEGSAVDDFLKPDRVIIGTENPAVREIMKQLYAPFMRKSKRIIFMDPASAEMAKYAANVMLATRISFMNELSGLCDTFDADIEQVRRAVGSDSRIGSAFLFPGVGYGGSCFPKDVRALTYMGDQKDCPMTIAQAVRDANYHQQDRFADRVLNYFKDKKDITIAAWGLAFKAKTDDTRESPAVRCIQKFLDAGFKVNAYDPEAKPAELEGRIKTTTRSYDALENADALVIFTDWQEFRNPNFDLITEMLNSPVIFDGRNLYDPSFIKKYGIEYHSIGRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR06</accession>
    <name>A0A1U9NR06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00579</name>
        <name evidence="4" type="ORF">STSP2_00642</name>
        <name evidence="5" type="ORF">STSP2_00647</name>
        <name evidence="6" type="ORF">STSP2_01273</name>
        <name evidence="7" type="ORF">STSP2_01543</name>
        <name evidence="8" type="ORF">STSP2_01654</name>
        <name evidence="9" type="ORF">STSP2_02279</name>
        <name evidence="10" type="ORF">STSP2_02284</name>
        <name evidence="11" type="ORF">STSP2_02879</name>
        <name evidence="12" type="ORF">STSP2_03423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67432">
        <property type="protein sequence ID" value="AQT67432"/>
        <property type="gene ID" value="STSP2_00579"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67494">
        <property type="protein sequence ID" value="AQT67494"/>
        <property type="gene ID" value="STSP2_00642"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67499">
        <property type="protein sequence ID" value="AQT67499"/>
        <property type="gene ID" value="STSP2_00647"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68118">
        <property type="protein sequence ID" value="AQT68118"/>
        <property type="gene ID" value="STSP2_01273"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68383">
        <property type="protein sequence ID" value="AQT68383"/>
        <property type="gene ID" value="STSP2_01543"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68489">
        <property type="protein sequence ID" value="AQT68489"/>
        <property type="gene ID" value="STSP2_01654"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69092">
        <property type="protein sequence ID" value="AQT69092"/>
        <property type="gene ID" value="STSP2_02279"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69097">
        <property type="protein sequence ID" value="AQT69097"/>
        <property type="gene ID" value="STSP2_02284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69684">
        <property type="protein sequence ID" value="AQT69684"/>
        <property type="gene ID" value="STSP2_02879"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70217">
        <property type="protein sequence ID" value="AQT70217"/>
        <property type="gene ID" value="STSP2_03423"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00579"/>
    <dbReference type="KEGG" id="alus:STSP2_00642"/>
    <dbReference type="KEGG" id="alus:STSP2_00647"/>
    <dbReference type="KEGG" id="alus:STSP2_01273"/>
    <dbReference type="KEGG" id="alus:STSP2_01543"/>
    <dbReference type="KEGG" id="alus:STSP2_01654"/>
    <dbReference type="KEGG" id="alus:STSP2_02279"/>
    <dbReference type="KEGG" id="alus:STSP2_02284"/>
    <dbReference type="KEGG" id="alus:STSP2_02879"/>
    <dbReference type="KEGG" id="alus:STSP2_03423"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18532" checksum="1BEA8A5B8B63F634" modified="2017-06-07" version="1">MRIGQQGTLTNVWAPKGSRPTAVKQTEYDWVYIFGAVNPVNGKSSAVITPTVNTDYMNHHLRFISEEAGKDVHVVLVLDQAGWHIAKQLVVPKNISLLHLPAYSPELNPIERLWAYMKSHYLSNRIYKNYEEIFNAGTVAWNNITSEMFCSICNTEWIKHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR51</accession>
    <name>A0A1U9NR51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03501"/>
    <dbReference type="EnsemblBacteria" id="AQT70295">
        <property type="protein sequence ID" value="AQT70295"/>
        <property type="gene ID" value="STSP2_03501"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03501"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13768" checksum="CFE55A4CFA58ED53" modified="2017-06-07" version="1">MPEFPNPFSGKVPDRKLTDSELARAIRLNIAAELEAIHLYEAHADATDNALAAAVLRDVADEERVHVGEFQKLLKILLPDEQAKLDEGEEEVEELAAGEHEEEEGPAEEEETKEVPTIGDIRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRB3</accession>
    <name>A0A1U9NRB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4405 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03464"/>
    <dbReference type="EnsemblBacteria" id="AQT70258">
        <property type="protein sequence ID" value="AQT70258"/>
        <property type="gene ID" value="STSP2_03464"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03464"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025517">
        <property type="entry name" value="DUF4405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14358">
        <property type="entry name" value="DUF4405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4405" evidence="2">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12057" checksum="BF58BAD5C55F01CF" modified="2017-06-07" version="1">MKRSSWNFAIDLFAFLVLLALTATGVVIRFVLPPGSGGRGQLQTGGRGREHIQELLGMTRDGWGSIHFYISLLFIVLMLAHLFLHWNWVKGYMKNCFRRDECEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG48</accession>
    <name>A0A1U9NG48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar biosynthetic protein FliO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_00041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00041"/>
    <dbReference type="EnsemblBacteria" id="AQT66903">
        <property type="protein sequence ID" value="AQT66903"/>
        <property type="gene ID" value="STSP2_00041"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00041"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT66903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15194" checksum="537F7276BA9272BB" modified="2017-06-07" version="1" precursor="true">MLEAIEKAKYLFIMLVFTACGVGFAAEDGGEGPDFGMKDGGDSYIGEILVSIVLVGVLGWLAWWLSKKYAPKLRSMRGKHMNVVETMYLGPNKTVHLLEVGAKTLLIGSTNENIRLLDDVTGTLADELDVENPEVFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG94</accession>
    <name>A0A1U9NG94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66952">
        <property type="protein sequence ID" value="AQT66952"/>
        <property type="gene ID" value="STSP2_00090"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00090"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32105" checksum="ADA04923A3A5FEB4" modified="2017-06-07" version="1">MRFKGVFLGAVLIAAVGGFSLAGVETSYDISVYYGYDNQFESDSATDGSPVSYDGRWAGYEPGQIIIAGSTWDATAAAEIDTVNGTYRTKASAMAYVDDSSAEDDYWVMSEGVINIRETLTFSQATTVTLTGSVHGNLAAQVSHSWNGNASASTDISWNFENPEIWTEDRWFGYYSDGWSADVIWNDDGTASTLPGTVPSTPDINETFSVEVDVPAGTILFNMEIESAAMAQAYLYGDATSANADALSDFGNTVLFEMQFEPGVTVTSEGGLFPVNVVPEPASLVFVTAGAACLIRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGA0</accession>
    <name>A0A1U9NGA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar phosphate isomerase YwlF</fullName>
            <ecNumber evidence="3">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywlF_1</name>
        <name evidence="3" type="ORF">STSP2_00100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00100"/>
    <dbReference type="EnsemblBacteria" id="AQT66962">
        <property type="protein sequence ID" value="AQT66962"/>
        <property type="gene ID" value="STSP2_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00100"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15982" checksum="41A3D742E1305B44" modified="2017-06-07" version="1">MNIAIGSDHAGYRYKERIKKLLEEKGHIVKDFGTYSEESVDYPKFIRPVAKAVAAGKFERGIVLGGSGNGEAMTANRVKGIRCAIAWDLRSARLSREHNDANVLSLGQRMLAIEEVLEIVELWLETEFEAGRHVQRIQQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK4</accession>
    <name>A0A1U9NGK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigD</name>
        <name evidence="8" type="ORF">STSP2_00073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00073"/>
    <dbReference type="EnsemblBacteria" id="AQT66935">
        <property type="protein sequence ID" value="AQT66935"/>
        <property type="gene ID" value="STSP2_00073"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00073"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="249" mass="28214" checksum="54F404AC59A24E3B" modified="2017-06-07" version="1">MQLKSLAARKYAQQQKQPNADQRVTQFLPMVHKLVSKVTSYLQPPLTRDDLVSAGTIGLIKAAHDYDSTKNAEFQTYAYIRIRGAIIDELRSWSFAPPSLNKQLQEAQTIHDEVMAHTGHSPSDEEVAKKMGIGVDKLYKTYEQGRARYFLSMSGYTEDEPALANVLAGSESGQPEQRIEREELVHDLADAIERLPQKQRQIVILYYQQELTMKEIAEVLEITESRVSQLHSSAVFKLGSLLKDHDNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGL1</accession>
    <name>A0A1U9NGL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67073">
        <property type="protein sequence ID" value="AQT67073"/>
        <property type="gene ID" value="STSP2_00213"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00213"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9951" checksum="168F7974323789FB" modified="2017-06-07" version="1">MEFKSSVEVADDAIRKMNERITDEVFLTIQNDRELMGAYLRAVQEEGLDRVNQTVGRAVKKAYGLENKEREGEPESTLIRSHMMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN4</accession>
    <name>A0A1U9NGN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloB_1</name>
        <name evidence="2" type="ORF">STSP2_00241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00241"/>
    <dbReference type="EnsemblBacteria" id="AQT67101">
        <property type="protein sequence ID" value="AQT67101"/>
        <property type="gene ID" value="STSP2_00241"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00241"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23074" checksum="65E110D16DAAAC45" modified="2017-06-07" version="1">MLIEQVVLGVFETNSYILRASAESKDCVVVDTGLDAGPLMNMLAAKRLNPLAILLTHGHADHTKGIDDLRQKYPDILVVMHKDDAPMLTSPVRNMSVLAKDIITHEPADILIKQEGPIEYAGLKLYVLHTPGHTPGGVCFYSEDDHVIFVGDTLFHNGIGRTDLPGGNHDQLIESIKSKLIPLHDKTVVYPGHGPKTSIKEEKQFNPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP7</accession>
    <name>A0A1U9NGP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66937">
        <property type="protein sequence ID" value="AQT66937"/>
        <property type="gene ID" value="STSP2_00075"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00075"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT66937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8062" checksum="85C8B49901CCE81D" modified="2017-06-07" version="1">MLTKPAARIIKKKNITIDGKISLDSAGNATAAGTQQSAPKPGAKATAKIIETTQTYATIEVTCGCGTKSYIQCNYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR7</accession>
    <name>A0A1U9NGR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67005">
        <property type="protein sequence ID" value="AQT67005"/>
        <property type="gene ID" value="STSP2_00143"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00143"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346505" evidence="2">
        <location>
            <begin position="23"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="56030" checksum="4B17E6B9B158BB60" modified="2017-06-07" version="1" precursor="true">MTLRYKILAAALVVLISFVTFAQPQRGSNRSHLLNPTQPVTAGQRGLRRSTSEIDYQNRNLLITGNVAGNRNFRGNVPYQSQYEFRGSLGSDDLNDFIRRSADPIYDRNPGTYTPYYLPSQTVTTLQRSGQSGLQSPTLLDPSVMNVYQVARPQDLESLTFTGTRDYFTGSTDDLERELDLQLSVLQVDEYQERELSPTDITSLVERDDLKPQRIEDMDEDEQDLRRGELERLERKFDESLEPIEPDEPLEPLTPEEMVEMQKEGRVIRERREAVEPEVLDEEEGDGMEVLPEEKMEEAEPEEGEEPVEEPELTPSQKARAREILEEYGSFEAFAEERYDKHMSRANGLLEEGKFYKAADAFDLAAIYKSKEPDVYAGKSLALFASGSYVTSSYLLQRTLKMEPGYVEEDVDLEELMGGKAKLSERVKDLQSWYDRNNAPELALLLSYVHYQMGDYDQARAILEQAGETVEGSEAVQLIEGAIEKAVKSSGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGX7</accession>
    <name>A0A1U9NGX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic 3',5'-adenosine monophosphate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67008">
        <property type="protein sequence ID" value="AQT67008"/>
        <property type="gene ID" value="STSP2_00146"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00146"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31548" checksum="8D305F85A35CAE3E" modified="2017-06-07" version="1">MQEFDFAVIADVQYADKEAEGSRYYRQSMAKLLQCAEELNKVEPAFVVQVGDLIDGSDNSLKDLQNVNAVLAQMKAPVYHVTGNHDFEGLSRSEFMAYTGMQDPYYTFSYAGWRFVFLDTMDLAVQGGWDKSSENYRKGMIMLEETADAGEEFAREWNGGIGAEQVAWLREVLGRAKREGEKVVVFGHIPVYPAGDKHNLWNSRQIVDVLEAPGNVAAYICGHNHAGSYGENNGVHYMTMPAMVDGESQNSYAIVHVSSDKLVITGRGAVPSREIAVDKPYGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ0</accession>
    <name>A0A1U9NGZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67201">
        <property type="protein sequence ID" value="AQT67201"/>
        <property type="gene ID" value="STSP2_00344"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00344"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13714" checksum="4DE7DCBCB700FCB5" modified="2017-06-07" version="1" precursor="true">MRYEWIALLIIVAGSLFCGFAQADVSGPDAEFNAPMRVQFDHRQGPVMKRNIFCGLPCCFLPIGLIALVLWIWALVDCVTKEPSEGNDKIVWVLVIVLTNWLGALIYLLVRRPQRKREIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGZ7</accession>
    <name>A0A1U9NGZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaK_1</name>
        <name evidence="6" type="synonym">dnaK</name>
        <name evidence="9" type="ORF">STSP2_00215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00215"/>
    <dbReference type="EnsemblBacteria" id="AQT67075">
        <property type="protein sequence ID" value="AQT67075"/>
        <property type="gene ID" value="STSP2_00215"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00215"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="650" mass="70476" checksum="8FA505851677D0CF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH57</accession>
    <name>A0A1U9NH57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG nuclease superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00214"/>
    <dbReference type="EnsemblBacteria" id="AQT67074">
        <property type="protein sequence ID" value="AQT67074"/>
        <property type="gene ID" value="STSP2_00214"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00214"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="12238" checksum="41E55CD8E58B4CA1" modified="2017-06-07" version="1">MLLFIGGGVKSYFVYILASKRNGTLYVGVTNNLRRRMWEHKNGLAEGFTRAWGVGRLVYFERFDHVDCAIRREKQLKKWRRRWKLELIEKDNAGWEDLAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH62</accession>
    <name>A0A1U9NH62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66940">
        <property type="protein sequence ID" value="AQT66940"/>
        <property type="gene ID" value="STSP2_00078"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00078"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9705" checksum="A190B81068544983" modified="2017-06-07" version="1">MNINPANRISTHMQDLLNNDRPGQKSRNSKALESTIGKDYSGTIERARNLGTVDRTAVAQARSLLQSGELETRQNIEATARRILTVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH79</accession>
    <name>A0A1U9NH79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66960">
        <property type="protein sequence ID" value="AQT66960"/>
        <property type="gene ID" value="STSP2_00098"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00098"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9395" checksum="4EC0971892BDB257" modified="2017-06-07" version="1">MKLNVKAFALACGLIWGLGVLLMTWYMIAIEGPSDDKFFLGRFYLGYNLTALGSVIAMVWGFFDALIGGAIFAWLYNFLSRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK0</accession>
    <name>A0A1U9NHK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial membrane flanked domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00428"/>
    <dbReference type="EnsemblBacteria" id="AQT67285">
        <property type="protein sequence ID" value="AQT67285"/>
        <property type="gene ID" value="STSP2_00428"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00428"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="241" mass="27278" checksum="4947FAF94DDC9886" modified="2017-06-07" version="1">MKRPNSVDSKQCPFCGETIRMEAIKCRFCAEFLNDDHAGIEPTSRFGGDADKRSDADETDSQDEGILYFGSPSVLSMMRTFVKFILFIAVAVVLLVLPLEDYLQKAVGERGGMTDNHHVLIEAIRHGAGIVLIVLAVLWLFWKIAVLKSTYYEVTADRIEWARGVFNRKVDNIDMFRIVDLSLQRTFFDCIFGIGTVHVITSDKTDPNFAFYKVPDARYLYDTLKHLSTGADQKRGVVHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL0</accession>
    <name>A0A1U9NHL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_00377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00377"/>
    <dbReference type="EnsemblBacteria" id="AQT67234">
        <property type="protein sequence ID" value="AQT67234"/>
        <property type="gene ID" value="STSP2_00377"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00377"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013002082" evidence="3">
        <location>
            <begin position="22"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="696"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="831" mass="93366" checksum="725BB70D867C18A1" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHN9</accession>
    <name>A0A1U9NHN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">exo I_1</name>
        <name evidence="7" type="ORF">STSP2_00164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00164"/>
    <dbReference type="EnsemblBacteria" id="AQT67026">
        <property type="protein sequence ID" value="AQT67026"/>
        <property type="gene ID" value="STSP2_00164"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00164"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013092514" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="616"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="756" mass="85145" checksum="59708FF176A08587" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT5</accession>
    <name>A0A1U9NHT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67502">
        <property type="protein sequence ID" value="AQT67502"/>
        <property type="gene ID" value="STSP2_00650"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00650"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7190" checksum="6258A44BD90486BB" modified="2017-06-07" version="1">MLWMYKTAKVKATGGFLGGKFNAGKLEVKLNELGKDGWELSTSFTTNKNYGETRDAVLVFKRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW2</accession>
    <name>A0A1U9NHW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">STSP2_00680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00680"/>
    <dbReference type="EnsemblBacteria" id="AQT67532">
        <property type="protein sequence ID" value="AQT67532"/>
        <property type="gene ID" value="STSP2_00680"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00680"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="447" mass="49686" checksum="45FC5A2E55CA21B3" modified="2017-06-07" version="1">MFSRILIANRGEIALRIIRACKELGVQSVAVYSEADKDAPYLKLADEAVCVGPANALESYLNIPRIISAAEITDVEAIHPGYGFLAENDHFAEVCEDCGIGFIGPSAESMRMLGDKVAAREIAKKAHVKTVPGSEGEIKDENEAIKLANKIGYPIILKAAAGGGGRGMRVVHNDISMRTAFQSAKAEAEASFSNGKIFIEKFIVQPRHVEVQVVADKAGNALHFFERDCTVQRRHQKLIEEAPCPVLDDKLREDLCKAAIKVVKQTEYAGAATVEFLLDKDKNFYFIEVNTRIQVEHPVTEMVTNQDLIKWQLKVASGQTLDIRQKDIKLQGSAIECRINAEDPDRNFAPSPGRIETFIPPGGPGVRNDTYLHQGMMISPYYDSMVCKLIVHQNTRAETISTMTRALDEFVVDPIKTTIPLCREIINHRLFSKNDFDTSFIEKHMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX1</accession>
    <name>A0A1U9NHX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory histidine kinase AtoS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00343"/>
    <dbReference type="EnsemblBacteria" id="AQT67200">
        <property type="protein sequence ID" value="AQT67200"/>
        <property type="gene ID" value="STSP2_00343"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00343"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="373" mass="41077" checksum="812ED5BAAB97E3FD" modified="2017-06-07" version="1">MSIQQTRTEFAPPDRAAAETIKSQVRTLQDCDFLHKLYDAVSEFVFIVNTHRQIIFANRAFLDFLGALDVEEIFGRRPGEVVGCIHARKNPAGCGTTNNCSACGAVNAVLTSINGKVSQQQCSITRETHGDDLELQIRTSPIKIGSQSFVVAAVSDISHENRRRILERIFFHDILNTAAALKLGTQGKFTSRTAKKAIAAAENNAARLIEEIRAQRDLLNAESGDLSINPESINSLSLLTDLRDTYHNPKGPAVILDPASQDIPLLTDPTIFSRVLRNMVKNAVEASDPDHRVTLGCTKNQTNARFTVHNPTHIPETDQLKIFQRSFTTKGKGRGLGTYSMKLLTERYLKGKVTFTSTPEKGTTFTAEIPLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI72</accession>
    <name>A0A1U9NI72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67300">
        <property type="protein sequence ID" value="AQT67300"/>
        <property type="gene ID" value="STSP2_00443"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00443"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="43136" checksum="80D00F490620396A" modified="2017-06-07" version="1">MIDNKPSLRLQWGQLLAVSGAHFLVDVYAGMMPAILPAVRDKFNISLTMGVALISTLYISCNIMQIGTGHVRAQKDKPLLMYIGLALGAVLCSFAAFPAQEAGVEASIYIKLTLILLVIIAASGLAMVHPEGLRAVHRLDGIQPAMSTAVFMAGGFMGFASGGYIATLLVEAFGFKGLYFLCLGSAAGIAAIYLLRVRLAVEKTPTEVVEQKVAKVTQLPFWPLMMIAIPATTATTVFCSLLPSRLEELGYALSYGGIATLIYGGGSAIGSFLWAPIAHRKGEMKLCAVLHLAGLPFLFAYLGMMDNGYAVILLAAAGFLSSSAYPLVVTMARSAKGLTLGLRMGLVVGGAWGLAAVPLQVLGPVAEEFGIQIVLWYTPIGYVIAGVAALMLAARGKAKMKIKNEATSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI92</accession>
    <name>A0A1U9NI92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA_1</name>
        <name evidence="7" type="ORF">STSP2_00591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00591"/>
    <dbReference type="EnsemblBacteria" id="AQT67444">
        <property type="protein sequence ID" value="AQT67444"/>
        <property type="gene ID" value="STSP2_00591"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00591"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="26"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="365"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="698" mass="75804" checksum="3F7B0BB1C3BBD21C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC1</accession>
    <name>A0A1U9NIC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purB</name>
        <name evidence="12" type="ORF">STSP2_00399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00399"/>
    <dbReference type="EnsemblBacteria" id="AQT67256">
        <property type="protein sequence ID" value="AQT67256"/>
        <property type="gene ID" value="STSP2_00399"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00399"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10397">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
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    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="372"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="477" mass="53253" checksum="1A079DB4533648B4" modified="2017-06-07" version="1">MAKDTSVYVSPLVQRNASPEMSALFSPDKKFGTWRRLWLELARAEKELGLEITDQQIQEMQSHLDDIDYDKAAEYEKKFRHDVMAHVHTFGDVAPTAAPIIHLGATSCYVGDNADLIIMREGLRILSEKLACLIDRLGNFAAEYREMPALGFTHYQPAQLTTVGKRATLWAYEFAMDLEELEYRDENMPFRGVKGTTGTQASFLALFNGVHDKVKALDEKVAAAFGFKKRCAVTGQTYQRKIDTLAVNALASVAQSAHKMCNDIRLLANLKEMEEPFAKSQIGSSAMAYKRNPMRSERATGLSRLVLSLASSPAMTASEQWFERTLDDSANRRVSIAEAFLATDGILEILINVASGLVVYPKVIEARVNSELPFMATENIMMAAVKAGGNRQDIHEHIRVHSHEAAAQVKQHGKPNDLIDRLKANPAFEKVDFNAVMDPSAYIGRAPQQVDEFIADIITPIRTKYQQSLDRQVELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC7</accession>
    <name>A0A1U9NIC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67671">
        <property type="protein sequence ID" value="AQT67671"/>
        <property type="gene ID" value="STSP2_00819"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00819"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17979" checksum="16184126E762DD08" modified="2017-06-07" version="1">MTEHIKRPLSLKIIAALFIVDGVLRILTMFVTRFQNSPITPIIGIITLFAGCGLLTLSSGWRTFILVILWFYMIYIPSIIAISIKYNIYKLTPVNTEIFQRPLFYIMAYLLCLFLFVLWMYRVLTRPEVRKLFTQKQTPKPQTEQPLTDQPTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NID3</accession>
    <name>A0A1U9NID3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xpsD_2</name>
        <name evidence="4" type="ORF">STSP2_00695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00695"/>
    <dbReference type="EnsemblBacteria" id="AQT67547">
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        <property type="gene ID" value="STSP2_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00695"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="639" mass="71489" checksum="158A323170F30E31" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG7</accession>
    <name>A0A1U9NIG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67524">
        <property type="protein sequence ID" value="AQT67524"/>
        <property type="gene ID" value="STSP2_00672"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00672"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15013" checksum="282FC3549346C7AA" modified="2017-06-07" version="1">MAKMNKTMMNELQATMDKAGKFDQLADLQAKRSELMEKVTKIDSQINDLIGTPSAKPKATRKRKTRGRGRAKKAKPDMPEKGTGPYKLVEVMGSKPMKKEEIAKKTGLSPATVSVYLNKFNCFSNVRGKGYTVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM4</accession>
    <name>A0A1U9NIM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low-density lipoprotein receptor repeat class B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67771">
        <property type="protein sequence ID" value="AQT67771"/>
        <property type="gene ID" value="STSP2_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00920"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="DUF5050"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5050" evidence="1">
        <location>
            <begin position="364"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="908" mass="100065" checksum="CE8CA4EBB2A94FF2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP1</accession>
    <name>A0A1U9NIP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rplM</name>
        <name evidence="5" type="ORF">STSP2_00607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00607"/>
    <dbReference type="EnsemblBacteria" id="AQT67460">
        <property type="protein sequence ID" value="AQT67460"/>
        <property type="gene ID" value="STSP2_00607"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00607"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16057" checksum="3E15CE6DC921D43C" modified="2017-06-07" version="1">MKSYVAKKEEVARSWKLVDAEGQILGRLASKVAMILMGKTKPTYTPNVDTGDYVVIVNAEKVKVTGNKELKKEYDRFSGYPGGRKVSSYAEVLERHPERILTNAIRLMLPKNRLGKEMLDKLKVYAGPEHNHSAQKPEKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP4</accession>
    <name>A0A1U9NIP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67799">
        <property type="protein sequence ID" value="AQT67799"/>
        <property type="gene ID" value="STSP2_00949"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00949"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="258" mass="29098" checksum="23A732E56D3E65BA" modified="2017-06-07" version="1">MVHLRREVFERYIKSVNDAYLKGDATEHTYRPAMQGLVEGLGENVHATNEPSRIRCGAPDFVVTRSRYGNHQTVGYIECKDLGADLRKIEKSEQIKKRYLPSLHNMILTDYVKFRWYVGGELRETAELAREGAGGKFVLSDEGVERVGEMLGQFMNVGVERIGSSKELAKRLGGMTRLMREIIKQTFEKESEKGSLHGQFDAFRKVLLHDLGEDEFADMYAQTIAYGLFAARCHINDVAAYGGKKGRAEGEKVSDPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR4</accession>
    <name>A0A1U9NIR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsA</name>
        <name evidence="7" type="ORF">STSP2_00825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00825"/>
    <dbReference type="EnsemblBacteria" id="AQT67677">
        <property type="protein sequence ID" value="AQT67677"/>
        <property type="gene ID" value="STSP2_00825"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00825"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002111">
        <property type="entry name" value="RpsA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="213"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="298"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="473"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="600" mass="66723" checksum="B0AEE6027F315B49" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT4</accession>
    <name>A0A1U9NIT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67831">
        <property type="protein sequence ID" value="AQT67831"/>
        <property type="gene ID" value="STSP2_00982"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00982"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13981" checksum="8CD6408DD6BE7751" modified="2017-06-07" version="1">MSKNRSFVPSDFSLRHVPLFIVVCIIMSVICILLGLALQTLPEFWRGLLFGVALSQIVTLTWLFPHKKIDINSLPQPSAEVRAKCNDPNCSFVEAVKLYREETGSSLSEAAAVLKAYRAERNTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIT7</accession>
    <name>A0A1U9NIT7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00884"/>
    <dbReference type="EnsemblBacteria" id="AQT67735">
        <property type="protein sequence ID" value="AQT67735"/>
        <property type="gene ID" value="STSP2_00884"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00884"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17894" checksum="D4C6FD915779FB25" modified="2017-06-07" version="1">MSKSLSKKQLKVLSVIQKGMPLSAAPYADMAESIGMATEEFLDVLRQWKDDGTIRRAGAVVNHLRMGVAGGIMVAWDVPDDSVESVGHLFAAFKQVSHAYERPRVPGWKYNVFTMVHGDTPKAVETTIDRMSEKSGITDFRKLRTVRELKKTPPVYVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU9</accession>
    <name>A0A1U9NIU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA_4</name>
        <name evidence="1" type="ORF">STSP2_00583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67436">
        <property type="protein sequence ID" value="AQT67436"/>
        <property type="gene ID" value="STSP2_00583"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00583"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="447" mass="51179" checksum="D78A456C69CD8B34" modified="2017-06-07" version="1">MTKIPFITSSTPYNDYDYDDIDRVSGVTYHDTTTESFGMDDLGNRGTVGLRDNTTDTYVVQPYAANEYASIDSVSLTYDNAGNMTADHRGFEYEYDYENRLVKVTNPGQSVTVAEFDYDALGRRIRRIKHDISETRLYFYNDNWQVLEEYDDSNVMKKLYVYGNYIDEVLAAGGTSSVYYLQDHLYSPVALLDTNGSTVERYEYNAYGQATVYTDKGTDGTWLTADDTTSPISALDNEYTFTGRRLDSLHANQLPLMQYRHRYYDPQMGRFLTRDPLGIDPGVMSFPNLFAVRTQYMGGLNLYEYVGSTSILYTDPYGLCKAGETNVCTKTWFLNKDFKFRYRGQIDPWGWFPSIGYIKEIFVRAIWDEKTVTLSVPCDSCTGKWDYANSERKEDVESKKGTEHSSNDAVTYPVKGRTEEVKAALREYARPDLPTEDSTDWSCVIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV4</accession>
    <name>A0A1U9NIV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">murG</name>
        <name evidence="14" type="ORF">STSP2_00802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00802"/>
    <dbReference type="EnsemblBacteria" id="AQT67654">
        <property type="protein sequence ID" value="AQT67654"/>
        <property type="gene ID" value="STSP2_00802"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00802"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="12">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="13">
        <location>
            <begin position="244"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT67654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46706" checksum="CB90E4D5A014894D" modified="2017-06-07" version="1">MLKTGFCVMAEGDVRHYFFAGGGTGGHIYPALAVAQQLAKIDPDAKIHFFCSTRDIDAQILSKSGFSYTPVEARGLSSRPVDMAKFVVSLVKGRKFATCQLRSVRENSVVIGVGGFASAPVVLAAKGLSIPVVMLNTDLVPGKANRFLARYAQRIFVQFEDSAKYFKTNATIEVTGCPLREELLEACGAHRRQNSSHTSQGSNAGADAKDQQGGDTSRGHGPPYINDYKKRAYEKFGLDAGKKTLLITGASSGCVNINKAMSRILYRLGKFADEWQIVHLAGRANYDEVRGYYENEPLECKVLDYCDEMGELYAAADLLVGRAGAVSVAEYAACGVPAVCLPYPYHKDKHQYLNAQKLVDAGAAVIVDDRPDDNIKTADELFIQLEKLMSDYKLREQMGEDSIKIARPDASLKIADCVADILKTLCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW8</accession>
    <name>A0A1U9NIW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Choline-sulfatase</fullName>
            <ecNumber evidence="9">3.1.6.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">betC_2</name>
        <name evidence="9" type="ORF">STSP2_00836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.6" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67688">
        <property type="protein sequence ID" value="AQT67688"/>
        <property type="gene ID" value="STSP2_00836"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00836"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047753">
        <property type="term" value="F:choline-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="483" mass="54412" checksum="AFC91610D2DF20E0" modified="2017-06-07" version="1">MCDWVVGRREFLKGLGLGAVCLGLSPVLGAVGGSSGKKGKPNVLFIAVDDLRPELGCYGQGHIKSPNIDRLADTGTLFRRAYCNVPVCGPSRVSLMTGLRVGSGAWKTAGIKREFTSLPAYFKRNGYTAVSNGKIFHHMHDREEDWSREPWRSVPIYHGGNWAKYNKNGLWQDEESGEHINPSKGRGPYYECADVEDDAYQDGKLAEKAVRDMRELASADEPFFLACGFWRPHLPLNAPKKYWDMYDAEEIELADNRFRPKNLPKQVRNSGEIFQYSEVREGFNSYEFHRRTRHAYYACVSYVDAQIGKLLDELDRLGIADNTIVVLWGDHGWHLGEHDFWGKHNTLNNALQSPLIVRDPRGEAGATDSLAEFVDVYPTLCELAGVAVPDHLDGKSLAGVMKDTDVRIHDAVFARWGDAVAMKTDRYLYTEWVKGGETTGRMLFDHKNDPEENINIAEKPENAELVKRLSGKVHEHLRILSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIX7</accession>
    <name>A0A1U9NIX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_00924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67775">
        <property type="protein sequence ID" value="AQT67775"/>
        <property type="gene ID" value="STSP2_00924"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00924"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="20688" checksum="1271F011FCF77135" modified="2017-06-07" version="1">MANQFVNTYLTIFFLLTPFFATSMFISLTQSFDGRGRMRMAAQTTAAALVVVLVMFLWGGSIFRVLGIDVYCFQIGAGVLLFLTAVSLVRGGKEDLKVAEGEDISLVPLAIPVIAGPGTIGTLVVMGSDISAAGRKAVAICAIVAAVLTVGVLLLTANRLEKLLGAKGLSALTKITGLVLSALAAQVVFGGVRNYLGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD2</accession>
    <name>A0A1U9NJD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67680">
        <property type="protein sequence ID" value="AQT67680"/>
        <property type="gene ID" value="STSP2_00828"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00828"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="46" mass="5282" checksum="EA15BC6FA8CF120D" modified="2017-06-07" version="1">MLELHPGFIIAIKVATSPAETIFTEIEPQYIPLSSFHFHPFHVMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE1</accession>
    <name>A0A1U9NJE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine transport ATP-binding protein OpuAA</fullName>
            <ecNumber evidence="8">3.6.3.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">opuAA</name>
        <name evidence="8" type="ORF">STSP2_01010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.32" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01010"/>
    <dbReference type="EnsemblBacteria" id="AQT67858">
        <property type="protein sequence ID" value="AQT67858"/>
        <property type="gene ID" value="STSP2_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01010"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="339"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="396" mass="43763" checksum="1FDA9163FE54A8D6" modified="2017-06-07" version="1">MSLLRIEKLAKIFGSHPKSALPYVEEGLNREDVREKTGQTIGIADVSFEVEKGEILVVMGLSGSGKSTLVRCVNRLIEPTSGRVYIGDDEITSMNRKQLLDIRRRKLGMVFQHFALLPHRTVLENSEYGLEIMGVEKSQRTNKAMEALEMVGLKGWENQLPRQLSGGMQQRVGLARALAVDPEIILMDEALSALDPLIRTDMQNELIDLQRKLGKTILFITHDLSEAVNMGDRIVLMKDGKVVQIGSAEEILTNPASRYVERFVEDLEKSKVLRAETIMRPIHEVAHTGDGPRTVLHKMREVGVSTLFVTDVHGVLQGIVRAEKASECAKAGDKDPAHMHDSDVKSVGLDANLQDVLGMMVENREPVAVVDDDKKLKGVIVIGHLLGALSEEGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJF5</accession>
    <name>A0A1U9NJF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein, lambda family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01089"/>
    <dbReference type="EnsemblBacteria" id="AQT67937">
        <property type="protein sequence ID" value="AQT67937"/>
        <property type="gene ID" value="STSP2_01089"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01089"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006429">
        <property type="entry name" value="Phage_lambda_portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05136">
        <property type="entry name" value="Phage_portal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="475" mass="53348" checksum="77D49D17A14577B2" modified="2017-06-07" version="1">MKLLNTIFNRTTEKKSASASELRRGPARIRGRYDAAQTTNENQKHWAAADGFSADMAASPEVRKALRERSRYEVANNSYARGIVLTLANDTIGTGPRLQMLTEDACLNREIENEFSSWSQSIGLAAKLRTMRMARCQDGESFAVLADNPSVGHPVQLDLQLIEADRVTSELSFNQSDDEIDGIRLDAFGNPVSYRVLRYHPGGAALDYQQKAVIIPASSMIHVFRSDRPELHRGIPEITPALGLFAQLRRFTLAVLTAAESAANFAGILYTDAPATGEADAVEPMDLIELERNMLLTMPGGWKMSQLDPKQPATTYAEFKKEILNEIARCLNMPFNVAAGNSSGYNYSSGRLDHQTYYKAIRIDQAFTASNVLDRILQSWLLEYSMFRGDRFASLPTHQWFWDGMEHVDPYKEANAQAARLKSKTTTLAYEYARQGRDWEEELRQLAREKKVMTELGLIEIKPKPAQESFQESNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ5</accession>
    <name>A0A1U9NJJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01131"/>
    <dbReference type="EnsemblBacteria" id="AQT67977">
        <property type="protein sequence ID" value="AQT67977"/>
        <property type="gene ID" value="STSP2_01131"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01131"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="39875" checksum="2A56D3687D7EFE74" modified="2017-06-07" version="1">MKKKRRYITFAMVAILALIAVIVIIQYRVRPSTAEAGSGRTLILEYTAEISGVPASNNPMKIFIPVAMDDEGQTLHGFEVAGDWDYEIVSEAEYENRFILINTTTEEYRANDEPVQVRYFVTRYDVSPVTAEGSRWPLTTEKERKYLTGTRMLPTTGKIAEEASSVAGNSYTDLTKARILYNHIVDTVEYDKSGEGWGRGDAMYACNVRKGNCTDFHSLFIAEARALGIPARFIMGLPLPADKDAGVIEGYHCWAEFYTDEKGWLPVDASEASKNPGKRDAYFGRLDRNRVAFTIGRDIRLPESKAEPLNFAIYPYVEIDGREHKDVEAAFEFEETTMSYVQIMLEGERNNDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJQ5</accession>
    <name>A0A1U9NJQ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">STSP2_01304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01304"/>
    <dbReference type="EnsemblBacteria" id="AQT68149">
        <property type="protein sequence ID" value="AQT68149"/>
        <property type="gene ID" value="STSP2_01304"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01304"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="574"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="756"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122124" checksum="708ED8A090C65ADA" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK72</accession>
    <name>A0A1U9NK72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-2-hydroxyglutaryl-CoA dehydratase subunit beta</fullName>
            <ecNumber evidence="2">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hgdB</name>
        <name evidence="2" type="ORF">STSP2_01371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
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    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT68215">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68215.1"/>
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    </evidence>
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        <source>
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    <sequence length="407" mass="43894" checksum="042AB54FAF20B638" modified="2017-06-07" version="1">MSTNCGCGAGGGNGQDERSGGCGADDGCGGASGPLGHFENMISNCYEYATAAKESGRGIVGIMCEYTPREVIMAAGALPVCLCGGSAEKAVEAHRELPANLCPLIKSTYGYVMDGSNLFLKMADVVVAETTCDGKKKMYELMARKKDMIVLELVQKPGEEGALARWTAEVVKLRDRLGEKLGVEITDEKLWEAVRVMNRERRLRRRIAELMEAEDPPLSGSEVLAMKSTISGIEADLVKYEEAAEYYGSGAAGSVGENRVRVLLTGVPTVHGAEKVVKLIEEAGGVVVCMENCTGVKPILEDVDEEAEDAIEAIAAKYLHLPCSVMTPNAGRLESIERLAKQYRADCVVDLVWQACLTYDVESRLVKELAEGELGLPYLKIETDYSPSDAARIAVRLEAMFEMVEGN</sequence>
</entry>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
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        </source>
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        <source>
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    <sequence length="893" mass="102087" checksum="54DC8D130D4ED16B" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="STSP2_01319"/>
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        <source>
            <dbReference type="EMBL" id="AQT68164.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
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    </evidence>
    <sequence length="35" mass="3508" checksum="A5322A9CCAA8FFD9" modified="2017-06-07" version="1">MLNAEVLIAAVAIWVVGIVWGCSCGDNAASGNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI3</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="STSP2_01400"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="15008" checksum="0F53923177EADFCB" modified="2017-06-07" version="1">MKSDKSIDPVIRWFPHEYEPEEIEFEWDYILEELDQLIDEVNQDGYWYCTVENFGWQNLSGHAYLEFESARDMLLKVLPKCECSFNIYRDGKVLRIQNYHHDSPTGEWYELTPITEKEFDEKSL</sequence>
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<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK9</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="3 4">
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    <dbReference type="EnsemblBacteria" id="AQT68345">
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        <property type="gene ID" value="STSP2_01504"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1143" mass="124479" checksum="F8A9CDDBC6AD27AE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL9</accession>
    <name>A0A1U9NKL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">gltX</name>
        <name evidence="12" type="ORF">STSP2_01515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01515"/>
    <dbReference type="EnsemblBacteria" id="AQT68355">
        <property type="protein sequence ID" value="AQT68355"/>
        <property type="gene ID" value="STSP2_01515"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01515"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="388"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="61066" checksum="70EA495F3C849718" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN8</accession>
    <name>A0A1U9NKN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ligT</name>
        <name evidence="4" type="ORF">STSP2_01517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68357">
        <property type="protein sequence ID" value="AQT68357"/>
        <property type="gene ID" value="STSP2_01517"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01517"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20932" checksum="154D2768B0746CA6" modified="2017-06-07" version="1">MRCFVAVDLESEVIDRLAAIQKDIAGRVDLGKGVKWVEPDCIHLTLKFLGEIRDEQVPEICRQVEQAAASFESFQLKVGRIGTFGRPARVLWAGIEKSEPLLKLQESIENAMVKAGFREENRRFSGHLTLCRIKNFSAGKKLQSVLKDYSDTDFGTSWVRSVCVYRSELTSKGPIYTPIMEIKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKS1</accession>
    <name>A0A1U9NKS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">suhB_1</name>
        <name evidence="3" type="ORF">STSP2_01696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01696"/>
    <dbReference type="EnsemblBacteria" id="AQT68531">
        <property type="protein sequence ID" value="AQT68531"/>
        <property type="gene ID" value="STSP2_01696"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01696"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29160" checksum="6DEF3FBBFC75AA49" modified="2017-06-07" version="1">MEHAYLSRLLEVATVAARLAGQRAMEEIKYTKTSIKNENEIVTSADPLCQRIIIDRIQETFPDHGFIAEEGDDGSMLFLAPRTREPIWWVIDPIDGTANFSHGILHFTVSVAAMHNGEPVVGAVFEPSTDSMFTAVKDDYAQLNYSRIGVSSEKMSSFTSVAIDSHFPDSALSSINELMQNTRFRALGSAALNLSYVANGGLVAALASTAKIWDIAAAALIVECAGGKVTTLAGEPLFPMDLDKYEPAEVSILASNGKVHKEIVDMFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY3</accession>
    <name>A0A1U9NKY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">purM</name>
        <name evidence="15" type="ORF">STSP2_01737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01737"/>
    <dbReference type="EnsemblBacteria" id="AQT68569">
        <property type="protein sequence ID" value="AQT68569"/>
        <property type="gene ID" value="STSP2_01737"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01737"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="184"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT68569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="38706" checksum="727D4D671D61422D" modified="2017-06-07" version="1">MSQEKKYISYAESGVNIDANDQMVDRISSSVKSTFGPRVMDLKNGFAGLFSLDSDSKLFKKNYDHPVLVACTDGVGTKILIAQQMKKFDTVGIDLVAMSVNDMLVQGADPLFFLDYLAVNKLDPENVAVMVESIAEGCRQANCSLIGGETAEMPDIYGQDEFDMAGFAVGVVEKDRIITGEKVRQGDIIIGLGSNGVHSNGFSLARTICFKQQKLNVTDKIDSLNGRAIGDALLDPTKIYVRPVVKLLEDFADTRPVHGMAHITGGGLVGNIPRVLPSDCDASIDKNAWQVPPIFDYLAQAGPVEESEMFRVFNMGIGFTLIVDPAHADAVMQNLSESGENVYRIGEIVGGSGKVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY8</accession>
    <name>A0A1U9NKY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Marine proteobacterial sortase target protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01631"/>
    <dbReference type="EnsemblBacteria" id="AQT68467">
        <property type="protein sequence ID" value="AQT68467"/>
        <property type="gene ID" value="STSP2_01631"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01631"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="397"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="940" mass="100891" checksum="10C945855AAA5524" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL30</accession>
    <name>A0A1U9NL30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68434">
        <property type="protein sequence ID" value="AQT68434"/>
        <property type="gene ID" value="STSP2_01598"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01598"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8196" checksum="2950A07AA0F9F7CF" modified="2017-06-07" version="1">MAGVWLKAVLKLLLVEYDFGGMPAVEAGSGCRSGAVSVLAENSAGLSSYWMVVGLVFVVSAAVDRSGLEFVDPFDGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL37</accession>
    <name>A0A1U9NL37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68444">
        <property type="protein sequence ID" value="AQT68444"/>
        <property type="gene ID" value="STSP2_01608"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01608"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22706" checksum="8643C3F920DCBE23" modified="2017-06-07" version="1">MVHLNGDVISYMKLFMKQVREELGVGGTMKLSVREYEQAAKPEKVKRELVNGTQADLQRLIEEKNDFYADILRANAWPTGFADVRAMEEYKESLAAYGSGQVDGGSFGLSTDGQAAASALLNRIKDLNKYEKVEGDAVKGVKVDVAAFYKELEKMFYDQFQVKDGGEAAEMSTKTAAAIGEAKADANKLQSGLSPESALILLQDRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL39</accession>
    <name>A0A1U9NL39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylyl cyclase CyaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01458"/>
    <dbReference type="EnsemblBacteria" id="AQT68300">
        <property type="protein sequence ID" value="AQT68300"/>
        <property type="gene ID" value="STSP2_01458"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01458"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21593" checksum="5779042ECADFED20" modified="2017-06-07" version="1">MNMEIEAKIKVAELASFAEKLKDAGAAFKQAERHHDSYFIDKGDGLSKSDRGLRLRQLDADGERSVFLTYKGPRQGGPFKSREELEVRVDDFETMSAMLVSLGFEKTLEFEKKRRVWLLDGCEVCLDELPVLGSFVEIEGPEEKAISGVLAKMGLAEKEHISEGYSRIMADALKDAGRQSKSVLFGEAGEERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL43</accession>
    <name>A0A1U9NL43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sigA</name>
        <name evidence="9" type="ORF">STSP2_01711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01711"/>
    <dbReference type="EnsemblBacteria" id="AQT68545">
        <property type="protein sequence ID" value="AQT68545"/>
        <property type="gene ID" value="STSP2_01711"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01711"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="384"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="552"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="408"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="621" mass="71594" checksum="5DC1D16D8731FA12" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL61</accession>
    <name>A0A1U9NL61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrous-iron efflux pump FieF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fieF</name>
        <name evidence="8" type="ORF">STSP2_01702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01702"/>
    <dbReference type="EnsemblBacteria" id="AQT68537">
        <property type="protein sequence ID" value="AQT68537"/>
        <property type="gene ID" value="STSP2_01702"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01702"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="220"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33503" checksum="53FE8DF93DBBC654" modified="2017-06-07" version="1">MDAHKINSANASIRKVTWGGIWANLGLAIVKVSIGWIGGSLALVADGVHSVSDMVTDFAVLLGAHFGAKEPDPKHPYGHGRLETFSAMFVAIFLALVGAGMIYQASVVINRVHLGHENIEPIGISVMWAAILSVIAKELLYRITRKVARRVHSPALYANAWHHRSDALSSIAVVIGFVAFRAGYEYADQVATIAVGLMIIWVAAKVIRDCLEEFAERAVDGETIKQIEHVVSSDERVKGYHKLRTRNVGREIFLDMHILIDPNMNVEQAHDIADELEADMHEQISRPVNIMVHIEPDIPKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL67</accession>
    <name>A0A1U9NL67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68474">
        <property type="protein sequence ID" value="AQT68474"/>
        <property type="gene ID" value="STSP2_01638"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01638"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="188"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="560" mass="61978" checksum="C295D51FDDCD7F7F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA3</accession>
    <name>A0A1U9NLA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease III (Xth)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01679"/>
    <dbReference type="EnsemblBacteria" id="AQT68514">
        <property type="protein sequence ID" value="AQT68514"/>
        <property type="gene ID" value="STSP2_01679"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01679"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36129" checksum="43A6826B4824FE4E" modified="2017-06-07" version="1">MRRRELIEFVCFAFFAAVLSVAGGCGHNYFSRIEAEEEAGGAEQAMEQSSDATVGSVDVMSFNVRYGTADDGDNSWRYRKELVLDIIRRSEAEVVGLQEALRFQLDWIRERLPYYEEVGVGRDDGEDGGEFNAILVDTRRFELAEDDTFWLSDTPEVAGSNTWAAGCTRICTWAKLVDRRTDEVLWVFNTHFDHVSARARERSSRLIAERIEEYAGGEDFVLMGDFNAGEDSVEMRYLRGVSEIDGQAVPVGMVDSFAQVRPEVRERGTFNGFDGNADGKRIDYIFVSKDVEIFDAAILRYNEGGRYPSDHYPVTAIIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK3</accession>
    <name>A0A1U9NLK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68813">
        <property type="protein sequence ID" value="AQT68813"/>
        <property type="gene ID" value="STSP2_01989"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01989"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011453">
        <property type="entry name" value="DUF1559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07596">
        <property type="entry name" value="SBP_bac_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30439" checksum="F4EEEB271DE66861" modified="2017-06-07" version="1">MKKSGFTLIELLVVISIIALLLAIMMPALGMVKERARRVTCGSNLKQVGISMLTYATDNKNNVPPSWMEERWRGTAGYAGWAAYWAYSVNTNATSEQDKMIPRNMGWLFDAGYLKDPEVFYCSSAGAFNKAWSYDHYRLSWPAAIGGNGTASTIRVSYNYIPQVRAKEVIRCGSSGRDVSVHMIGYKVSNMTSSTSLAADLINSQEHIMHRAGGNAPAGINVLHGDGHVVFNNDKEAINADDFWGDLGDDKSNLPNQNGYNLRALLGLFKGTARIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ9</accession>
    <name>A0A1U9NLQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose 5-phosphate isomerase KdsD</fullName>
            <ecNumber evidence="8">5.3.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kdsD</name>
        <name evidence="8" type="ORF">STSP2_02058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02058"/>
    <dbReference type="EnsemblBacteria" id="AQT68882">
        <property type="protein sequence ID" value="AQT68882"/>
        <property type="gene ID" value="STSP2_02058"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02058"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019146">
        <property type="term" value="F:arabinose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35985" checksum="DE16DE95B7EF39BA" modified="2017-06-07" version="1">MKSNFNGLGIKVQYDLDFARTVIEDEAKAVGSLARIIDGSFEKAVDLMCNCTGSVIVSGMGKAGIIGNKISATLASTGTPSHFLHPAEGIHGDLGRVQANDVVLALSHSGESEEIVRIIEPLKQREIKLISITGNPKSSLAKHSDVVLAMGKQVEACPLGIAPSVSTTCMLALGDALAFTIMKAREFSTEDYARFHPGGAIGANLITVGQSMMFKPGEKLPLAQTSDTIDDMFKRLEGVKRRGAVMVVNDKGQLAGIITDADLRRAMAKFDGELFAKGCTEIMTPDCKRVTAETLAAEAMAIFHKYRIDELPVVDENDRPIGLIDVQDIVAIKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR6</accession>
    <name>A0A1U9NLR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01919"/>
    <dbReference type="EnsemblBacteria" id="AQT68747">
        <property type="protein sequence ID" value="AQT68747"/>
        <property type="gene ID" value="STSP2_01919"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01919"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="29383" checksum="4F94A3ED0B99EDD9" modified="2017-06-07" version="1">MNRKGFTLIELLVVISIIALLLAIMMPALSMVKEKARAVTGMSRVKQWGLCYQLFTNDHDGSFPEFKHDTTNTTFMYDLKDYYADINEMRFCPSAKKVSSSNPTGVEEGSYFGSTLEAWKVNVSDASWMEDDDIGAGSYGENSYIRKLEGNSKAWGRANMKQANTVPVLMDARWNNAWPDNGQPLRRSSTTDQEFYNAGNWITISCFVMKRHGDGINMTMADGSAQKVDAEELWQFRWNRDFEREDFVDLAFMKWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM78</accession>
    <name>A0A1U9NM78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">STSP2_02237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02237"/>
    <dbReference type="EnsemblBacteria" id="AQT69052">
        <property type="protein sequence ID" value="AQT69052"/>
        <property type="gene ID" value="STSP2_02237"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02237"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7109" checksum="7B9D8CF059447099" modified="2017-06-07" version="1">MPKQKSHKGLSKRVKLTGKGKVRRKRANGSHLMSTKDARRRRRISKACVVEGVVADKIKAALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD9</accession>
    <name>A0A1U9NMD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68904">
        <property type="protein sequence ID" value="AQT68904"/>
        <property type="gene ID" value="STSP2_02081"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02081"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22919" checksum="8E6EBA8E10B5EFFD" modified="2017-06-07" version="1">MNQQAIHLNKKPARSRKHRDHKKMVMAFGLLAVMGFMWARVLFFSDEGPEKAQAQAMAELEEQQNSENQIEISYVQLPFEGGRHDRLENDLFGPRSWLEPETNGEAKDVAVTVKEPSAQERQRRLVEKMAETIKVEAIIVGQDGTESEAFIGNNIVTEGSTFLISYDGKEYGFTVADISRSKVIVKWNEFEVAIGMSQPDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NME3</accession>
    <name>A0A1U9NME3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L-lactate dehydrogenase operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lldR</name>
        <name evidence="5" type="ORF">STSP2_01846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01846"/>
    <dbReference type="EnsemblBacteria" id="AQT68676">
        <property type="protein sequence ID" value="AQT68676"/>
        <property type="gene ID" value="STSP2_01846"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01846"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26346" checksum="151C4827069A8EE8" modified="2017-06-07" version="1">MKLTPVAKMTLVDMAEGKVREAIVESGMKVGDVLPGELELAERLGVSRNVMREALSRLRMLGVLESRKRRGMVLKEPDLLDGLAKVIDLPVISKPVKQDLFELRLIIELGMAELVFDRKTDEVVAELEEIVAEEEKESGGGAVVAPEVEVDFHTQLFKMAGNGTLMRFQSLLGPFFDWKKQEGEIAKFHESGDGVTHRDIVEILKEGTKAEFLEAMQRHLRPHVEWINQKRCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG2</accession>
    <name>A0A1U9NMG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68696">
        <property type="protein sequence ID" value="AQT68696"/>
        <property type="gene ID" value="STSP2_01868"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01868"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15077" checksum="92E8739FDA405B56" modified="2017-06-07" version="1">MGTTNTPTHPAGPVRDTATRFIDTTRISLSKELLAIMAHPEKLVAFLAFSPKLHILLAVPGAAEETREYLSNNSGGSLHVDHKVFGKTVSVSSNARINLPSYIWDHISCVSGDCVRLFVREKGIEIYPEAEGDKLLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG7</accession>
    <name>A0A1U9NMG7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ORF">STSP2_02329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02329"/>
    <dbReference type="EnsemblBacteria" id="AQT69142">
        <property type="protein sequence ID" value="AQT69142"/>
        <property type="gene ID" value="STSP2_02329"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02329"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="31176" checksum="418DA173EE64BFCD" modified="2017-06-07" version="1">MTDQRRPKNDILEWPLGSLDFSQGCIIMGILNVTPDSFSDGGTYMDTDSAIERALQMVHDGARIIDIGPESTRPGSKPVSAEQQIARAIPVIEKITQRTDTVVSIDTQDSRVAEAAIKAGASIINDVSAFGDPKMPEVAARYNAVSILMHMKGTPSTMQKEPSYDDVVSEVLEYLTSRIEYAKGFGLPAEYLMIDPGIGFGKTYHHNLELLKHLDRFCRTDHRVLVGTSRKKFIGRITGREIPSERLFGTAATVAASVLAGASIVRVHDVAEMAEVVQVCNAINNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ3</accession>
    <name>A0A1U9NMJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Erythronate-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.290</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pdxB</name>
        <name evidence="9" type="ORF">STSP2_02328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.290" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02328"/>
    <dbReference type="EnsemblBacteria" id="AQT69141">
        <property type="protein sequence ID" value="AQT69141"/>
        <property type="gene ID" value="STSP2_02328"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02328"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033711">
        <property type="term" value="F:4-phosphoerythronate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12158">
        <property type="entry name" value="ErythrP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01825">
        <property type="entry name" value="PdxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020921">
        <property type="entry name" value="Erythronate-4-P_DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024531">
        <property type="entry name" value="Erythronate-4-P_DHase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038251">
        <property type="entry name" value="PdxB_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11890">
        <property type="entry name" value="DUF3410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="6">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="7">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3410" evidence="8">
        <location>
            <begin position="288"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="384" mass="42051" checksum="18B0B8A05F1D4443" modified="2017-06-07" version="1">MKIVADQNIPFVADCFSSVGQVTTLAGRDIDTEAINDADALLVRSITNVNEELLDGSSVKFVGTATIGTDHIDQNYLKTSGIGFASAPGSNANSVAEYVVAALLAVAKKHKFTLEGKSIGIVGVGNVGSRVEAKCRALGMIPVLNDPPLKRKTSDDKYRPLSELYDCDFITLHTPLTHEGEDKTFHLVDQNILANLKQGIYLLNTSRGPVADNAAVKDALNKGHLAGAILDVWEGEPVVDPELLLKAEISTPHIAGYSYDGKVGGMLMIYNALCSHFDLQPRHTAHDFLPEPQVPDITVDANPDDEQKIIHDTVQQIYVINRDDFNMREILLITDSERGPFFDKLRKEYPIRREFQNTVATLRGTNDSLASKLKGIGFQVRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMK1</accession>
    <name>A0A1U9NMK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">pyrD</name>
        <name evidence="11" type="ORF">STSP2_02250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02250"/>
    <dbReference type="EnsemblBacteria" id="AQT69065">
        <property type="protein sequence ID" value="AQT69065"/>
        <property type="gene ID" value="STSP2_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02250"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31814" checksum="51F237953FD3A278" modified="2017-06-07" version="1">MDISVDFAGINLKNPVFTASGTCGYADELSPFMDVAALGGFITKSISLQPRKGNPTPRIVETDAGMLNAIGLANIGLDRFLDEKIPLIEELDTAVFVNLAGQTIDDYVAVTEKLAKIDAIAGFELNISCPNVKKGGITFGTDPEQIENITKHVKKVAGNKPLMVKLTPTVTDISVTAQAAIDGGADALSLVNTFTAMAIDIETRRPVLANRTGGLSGPAIKPIAVYLVNKVYNEVAKPAGIPLMGLGGITTASDAIEFILAGATTVAVGTASFPNPAASAQIVEGIENYCVEHGISSVKELTGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NML2</accession>
    <name>A0A1U9NML2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69037">
        <property type="protein sequence ID" value="AQT69037"/>
        <property type="gene ID" value="STSP2_02218"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02218"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323972" evidence="1">
        <location>
            <begin position="24"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="310" mass="34930" checksum="8135C86F5CAE4253" modified="2017-06-07" version="1">MKRTIQILVFATIFNLAGAISHAQVIYGDSFSDGLEKAKNYKTVLVVLAHGNWNRWNERLYEDVFEDKSMSQMLNKGRAVLTDVRVLQSATDEQKNKNKSRNEGFKAKGVHTYPAVIGYSSEGKLLGIRQGVDLPKDIEQARKSIAQFAKLCLEYESLKDESEKAKSAGDKDTELAALAKIGEMPLNRPDNLLKRIKQLDPTDSKGHYARLTFPHWQKLFSDVTSRTQKGEGAAVENELKKMLRTDAYTKVQRAFVHVALGNCYRRQEGKDKQAASSFKEAWGIAPETFPGQIGKRCYEAWYKSTDIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMP5</accession>
    <name>A0A1U9NMP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit alpha</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpoA_1</name>
        <name evidence="3" type="ORF">STSP2_02046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02046"/>
    <dbReference type="EnsemblBacteria" id="AQT68870">
        <property type="protein sequence ID" value="AQT68870"/>
        <property type="gene ID" value="STSP2_02046"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02046"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_A_CTD" evidence="2">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_A_CTD" evidence="2">
        <location>
            <begin position="365"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="48811" checksum="05140B3EC8E0AE19" modified="2017-06-07" version="1">MVMESIADATEALFGNQMISFADARKIENSVNSSEYNKIKFAEEVDKNKSNQLAAGIGMLFLGRYAEAVELLKKSSDCKEKFFFLGCALRGAEKYDEALEAFDKALKQKADNLLVVLEKIDTLRLAKKFEEAEKQAETCANFAKVSADYHYQLGRLLSDQGKYEEAISNFEIAAELDPNHHRALFHLAFACDLRGDDEAAIDYYKQIKASSPVYVNALLNLAVLHEDRGEYEKAESCVEMVLNCHPNHKRAQLFLKDILSSQDMVYDEEKEKLKSRRNKILEIPISDFELSVRSRNCLKKMNIHTIGDLLRITEAELLSYKNFGETSLTEIKRILEQKGLRLGMALEDKKPPAVEPEAVDGADAEMLGKTVDDLELSVRARRCLQRLNIRTLAELCARTEAELLGCKNFGVTSLNEIKERLSEFGLGLRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMU2</accession>
    <name>A0A1U9NMU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sigM_1</name>
        <name evidence="3" type="ORF">STSP2_02002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02002"/>
    <dbReference type="EnsemblBacteria" id="AQT68826">
        <property type="protein sequence ID" value="AQT68826"/>
        <property type="gene ID" value="STSP2_02002"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02002"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="21520" checksum="A63FAC100903B9C2" modified="2017-06-07" version="1">MSQEYINDVNKQQMDRHDEFMRLYLPIQRTLYGYVTASLSGWDGVDDVVQDTLSHMWAHFDSFERGSNFAGWAITIARYRILEHVRKDKKEKNMFSEDALDSIAAASAECSSYEQCRRDALRGCLGKMGDDDRRLLRLRYSGSATIRGIADQLDRSVHTLYKTFRRLHIALFNCIERSLAQEDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMV3</accession>
    <name>A0A1U9NMV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Melibiose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">melR</name>
        <name evidence="5" type="ORF">STSP2_02471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69282">
        <property type="protein sequence ID" value="AQT69282"/>
        <property type="gene ID" value="STSP2_02471"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02471"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="237"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="345" mass="39585" checksum="3A5783D53D4BF3FC" modified="2017-06-07" version="1">MKRTSKPQPAIFYDVNGTHRADTCEPLRNAKARGDLYHAAFAHGTYPGQRMPVKMLPELCVACVWDAKEDQNWGLPKHRNEGIELGYLTRGTLDFTVDDQHYELKAGDFTVTRPWQPHTVGNPNVAASRMHWLILDVGVRRPNDPWQWPDWINFSEHDLAGLTKLLSFNEQPVWRGNKQIEKCFEKIAHHVSSDSPEDVQTRLMLYINELFLEAYEMLKTKQIKLDVKLGSTQRSVEMFLSGLSEHLDYPWTLESMAEHCNLGRSRFAHYCKRITNMTAADYLAHCRVEKSKELLANAPDASVTDIAFSCGFESSQYFATVFKKKTGISPTQYRKVETEQQQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK5</accession>
    <name>A0A1U9NNK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione-binding protein GsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gsiB</name>
        <name evidence="3" type="ORF">STSP2_02566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02566"/>
    <dbReference type="EnsemblBacteria" id="AQT69377">
        <property type="protein sequence ID" value="AQT69377"/>
        <property type="gene ID" value="STSP2_02566"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02566"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012414391" evidence="1">
        <location>
            <begin position="24"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="599" mass="68074" checksum="FD6DF1E1F061A5BE" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK6</accession>
    <name>A0A1U9NNK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Signal peptidase I</fullName>
            <ecNumber evidence="3 4">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sipT</name>
        <name evidence="6" type="ORF">STSP2_02604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02604"/>
    <dbReference type="EnsemblBacteria" id="AQT69415">
        <property type="protein sequence ID" value="AQT69415"/>
        <property type="gene ID" value="STSP2_02604"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02604"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="142"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="437"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="60760" checksum="2236694EF1BC5C58" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM6</accession>
    <name>A0A1U9NNM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide core heptose(I) kinase RfaP</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rfaP_2</name>
        <name evidence="1" type="ORF">STSP2_02745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69552">
        <property type="protein sequence ID" value="AQT69552"/>
        <property type="gene ID" value="STSP2_02745"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02745"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="267" mass="31761" checksum="7BC259F9AC10B2CF" modified="2017-06-07" version="1">MRNIQFAGKWREFFSQQGVVEYEDFFEFDQEQVVNQNTKRMVAYFTLGRGENRREFFIKRFKKPHFKDTWFAFRNFRTICSQGRLEWLSARTLLDNGIGTYIPVCYGSDMKGPFEESSFFITEKLAGQCLADICNQRWEQLQQNEKEMLITHIGRLARRIHDAGISMPDLYVWHIFVDTDSAGNQKLSVIDLHRMKVGAKLNRQLEFARNLGAFDFSMRSEYFDDHLREIFFQSYVGDGIEWDQQQFRTKINARSAVLASRRRRVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNN0</accession>
    <name>A0A1U9NNN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidative stress genes repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">perR_2</name>
        <name evidence="3" type="ORF">STSP2_02690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69499">
        <property type="protein sequence ID" value="AQT69499"/>
        <property type="gene ID" value="STSP2_02690"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02690"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15787" checksum="629621D14EA7B2D1" modified="2017-06-07" version="1">MAETKFEQLCRDKGLRLTPQRAAIYRILAGSKEHPSAESVWREVRKEMPRVSLDTVNRTLLTFAEAGLAFVVAGSGGAKRFDANLDSHQHFKCVKCNEIVDFHHEPFDDILVPPELPSGFRVLRATVYLEGLCDNCKENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV7</accession>
    <name>A0A1U9NNV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Cysteine desulfurase</fullName>
            <ecNumber evidence="5 7">2.8.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nitrogenase metalloclusters biosynthesis protein NifS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nifS</name>
        <name evidence="9" type="ORF">STSP2_02786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02786"/>
    <dbReference type="EnsemblBacteria" id="AQT69593">
        <property type="protein sequence ID" value="AQT69593"/>
        <property type="gene ID" value="STSP2_02786"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02786"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="385" mass="42052" checksum="74BE2927F7DE513A" modified="2017-06-07" version="1">MKTIYLDNNATTRVDPEVLDAMMPYLSDLYGNPSSMHTFGGQVGQKIRQAREQVAALIGCDPSEIIFTSCGTESDNTAIRSALQTHSDRSKIVTTRVEHPAVLSTCRELEHHGYSVVEIGVDEKGRLNMDEYVDAVDDDTAVVTAMWANNETGVIFPVEELAEIARANGAVFHTDAVQAVGKIPCDMSESKIDMMSLSGHKLHAPKGVGVLYVRKGTRLAPFMLGGHQESGKRAGTENVAGIIAIGKACEIAQKWMEDENTRVKAMRDKLEKTILESCPDCFVNGDTENRLPNTSNISFEYIEGESILLLLDRLGICASSGSACTSGSLEPSHVLRAMGVPFTAAHGSIRLSLSRFNTDEEIEFVAKKMPEIIKRLRELSPFVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW5</accession>
    <name>A0A1U9NNW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69206">
        <property type="protein sequence ID" value="AQT69206"/>
        <property type="gene ID" value="STSP2_02393"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02393"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="416" mass="47856" checksum="4B028182FCD4B45B" modified="2017-06-07" version="1">MAKKSKRSSKKVPGTIYKNGSRYWWKVRLPGSSKTKSVPLVPQGAKQATPYKDVAIECAKLMWSKAVFDSQQKVEQVDTIAELVKAYLEFAQTYYIHDNGREIQAIKYATKQLVDNFADLPIEEFGPRRLKDVREFMIEENLSRRVINSRVGIIRRMFKWAVSEQIASPMAYHALGAVDGLRRGYTNAREVEPVRAIDEEYVYKVLPYASDTIAAMIELQLLTGMRPCELTIMRPCDITKKDDVWHYRPQKHKNSFRGLERIISIGPRGQEILRPFLLKKRTDYCFSPQETENKRRRELTLTRKTPLSCGNRPGTNRKAKPQRAPRDHYDTRSYGQAVKRAINTARREIKRQGGNPDEELPKWTPYQLRHTAATKIRKVFNYETAGALLGHSNLSATQIYAERNQGLADMAAQQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP47</accession>
    <name>A0A1U9NP47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69380">
        <property type="protein sequence ID" value="AQT69380"/>
        <property type="gene ID" value="STSP2_02569"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02569"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012572549" evidence="2">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="386" mass="42618" checksum="278FBEDCE23ED856" modified="2017-06-07" version="1" precursor="true">MKNIRISIVIVCVAAIFVSFASVTRAAETQEIDALIQRAGTSAADLSSSDREIISEFVSDSIDELVSAQNGSEMIAVRTGISTRMLSDKNSKYRLAFSDILEENLLDAVNYVSSWEAGERKKQIQTNLIILAARLQSPQLVDFAVNMLSQDDIVIRYWAVKSLTGDRLVKMLNDPITADKNITDKILTALNGYIGPNTTAEVLAVISRFAADLEAPATNDMLLKIVDVRMRDYEDWTVDYEKADAEILAVLAGEAQNLSGSQKARFLGAFAQLYSYTIQRYILGQDLLDKENENYLIATMAEVEQKILPKLLGRPQDSIRKALDRGNLTELKQEHDRLFGSTGRKGLLEYDNTLDYGTDKAGQKLSGPRTLSPPPVPDLGAESENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP48</accession>
    <name>A0A1U9NP48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid protease GluP</fullName>
            <ecNumber evidence="8">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gluP</name>
        <name evidence="8" type="ORF">STSP2_02886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69691">
        <property type="protein sequence ID" value="AQT69691"/>
        <property type="gene ID" value="STSP2_02886"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02886"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="110"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="387" mass="42799" checksum="257271AE79A9E512" modified="2017-06-07" version="1">MRVNLVAYNAWKSAIRSFLDFFSYAGGFGPSIEVKAGVLEWGPVIFWTDIERAEQMLIPLEVDVPEERWPVVNWFIIGACVVIFGFEMLCFAADDFSLFEPFVLDGFGLTGMFGHMWLHGGIMHLIGNMVFLWIFGNAVCAKLGNIRFLLFYLAVGLISGSAHVIFGGERAIGASGAINGVVGIFLVFFPANAITCGFIWWLIPPIYTTFTLSSYWMILFWLTFDIWGAFSGIESGTAYWAHVGGFAGGFGLGVLMLKMGWVEMERYEESLLSMLGMDRKMVAVKAKDAGLEAKKVEDKNSAYQEAREARLKRERERWKREAAEAARAKAERAAEQVQRAKAGGGVIKFACKCGRVIRVKGELAGRKGRCPECGGTVIVPGGRQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP90</accession>
    <name>A0A1U9NP90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinine amidohydrolase</fullName>
            <ecNumber evidence="5">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crnA</name>
        <name evidence="5" type="ORF">STSP2_02811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02811"/>
    <dbReference type="EnsemblBacteria" id="AQT69617">
        <property type="protein sequence ID" value="AQT69617"/>
        <property type="gene ID" value="STSP2_02811"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02811"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29577" checksum="BE17789A44EBF86E" modified="2017-06-07" version="1">MSSQKPTINDWDLSTTNLRRLKNVNYEVAVIPVGATEAHNWHLPEGLDFMHAGHVARESCRKAWQNCQNIVCLPPLPYGVDCNQMSFPLAIHLSQSTLDQVMREIITSLKHHGIRKIVIVNGHGGNNFEPFVRQVQSDLDVHVFLCNWWKIGFDKYDEIFTRPDDHGGQMETSVAMALCPELVEIENAGTGHAPPFRFEALNKGWVKTSRDFGKLNDHCGVGNPEGSTPERGRQYLELACDRLSGFLTDLATTPIDDNFPMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC3</accession>
    <name>A0A1U9NPC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69568">
        <property type="protein sequence ID" value="AQT69568"/>
        <property type="gene ID" value="STSP2_02761"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02761"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18372" checksum="92C048BC0EF18FC4" modified="2017-06-07" version="1" precursor="true">MTRRSKIKNRRAFSLLEVLIAVVIISLGMVSVLAASTAFTESNASGIELSTAEFLVEEVRELTTSLSVTDPNSDDDTFGPEYYESSVADYDDLDDFDGASFSPPIDIKRNALSNYAGYTQQVTVRNVSANDFSSVQYDHSTNFVRVTVNILLGGEQITSSSWIRANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD4</accession>
    <name>A0A1U9NPD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69781">
        <property type="protein sequence ID" value="AQT69781"/>
        <property type="gene ID" value="STSP2_02978"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02978"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="482" mass="55192" checksum="18A060CCD8366EEE" modified="2017-06-07" version="1">MMSEHVDYLEEERKKIWQAITDLRKTSEAIEQSIATLDNEVNKKTSDYEADAKRSAKQAAYNRTRTKTILQEANDLQLRLNELFEDINRFQESIPEINSLYVSVKEKSSKVDQIRESIQKQSDLLEQKHGQAKSDLEELTNNIKKAQEAYENIEKAETDVQELYKKITIAHSQAAKRNIAIKDIHREVFGYSYEDEETGESKIVEGTKDALENAYDILERKREELAYELDELRNKTSEKYEELLSVELEKGERLRAKIRGLLPDAMTAGLSHAYERKRKEEEVHLGKARSLFNWSIFFLSATAVIPVVIGIVFLGNDKSLEEVILKIPRIVVGILPIYIPLFWLAMAANKSVKLSKRLIEEYSHKEALSKTFEGLSKQVDALDDDNSKELRARLLYNIISASSENPGNLIKDFSKSDNPIFDVFDKSAALSESLKKLSFIPGIEVVLQKINKEQKQAEEEAEKTLEQSILTADELEEEPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH0</accession>
    <name>A0A1U9NPH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="2">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phrA</name>
        <name evidence="2" type="ORF">STSP2_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.99.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02595"/>
    <dbReference type="EnsemblBacteria" id="AQT69406">
        <property type="protein sequence ID" value="AQT69406"/>
        <property type="gene ID" value="STSP2_02595"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02595"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01084">
        <property type="entry name" value="DNA_PHOTOLYASES_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="452" mass="52472" checksum="FB7A11D70641B791" modified="2017-06-07" version="1">MIQDERIEILNDSPVHDGEYVLYWMQAAQRAQCNHALEYAIDQANELSLGVVVYFGLTDDYPEANERHYWFMLEGLSETITEVQKRGIAIVVHNGDIVKGLIEHSQKAAMVIVDAGHLHIQRKWREQAGEKLDRRFVEIETNLIVPIETASQKENFSAGTLRPRINKHLDRFMVDLKERKPKVKTTKMNLKGFDVQNASKAIKKLKLDRSVSKSRFYQGGTTQANKFLDEFIDHKIKDYADGRNDPCKDVLSNVSPYLHFGQISPLHIALRVKSYTGKKEGKEAYLEELIVRRELAHNFVAYNDDYDKYEGLPPWAKATLEHHSKDKREHLYSLEELEQAQTHDPYWNAAQHEMVITGKMHGYMRMYWGKKILEWTKNPAQGFELALYLNNKYELDGRDANSYTGIAWCFGKHDRAWAERGVFGKVRYMNANGLKRKFDPDAYVEKVSRLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP8</accession>
    <name>A0A1U9NPP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69486">
        <property type="protein sequence ID" value="AQT69486"/>
        <property type="gene ID" value="STSP2_02677"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02677"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17284" checksum="BA77A48B76174424" modified="2017-06-07" version="1">MKKSPDMEKLESVLRSSKLVAGGFLGDDPRDLTEILDTDAAAVEHHNKTHKQIAKRMRELTEAGIARLGMLAEVEGELEVMVDEAKGILVCPWPHSGRFAKRITAVRNKRTGQTIQWSDLNIHLIEEHGFYEGKGSAWRLEPDELIRVVFPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU1</accession>
    <name>A0A1U9NPU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmC</name>
        <name evidence="7" type="ORF">STSP2_03043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03043"/>
    <dbReference type="EnsemblBacteria" id="AQT69845">
        <property type="protein sequence ID" value="AQT69845"/>
        <property type="gene ID" value="STSP2_03043"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03043"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7631" checksum="898CEAAA8EA46398" modified="2017-06-07" version="1">MKAAEIRDMRSDELQAKLEELQKQVFTLRSQAMTENVENVRAMKNVKRDIARVKTIIRENEIKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ46</accession>
    <name>A0A1U9NQ46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialidase</fullName>
            <ecNumber evidence="4">3.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nedA_6</name>
        <name evidence="4" type="ORF">STSP2_03231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1U9NQ46"/>
    <dbReference type="STRING" id="1936003.STSP2_03231"/>
    <dbReference type="EnsemblBacteria" id="AQT70029">
        <property type="protein sequence ID" value="AQT70029"/>
        <property type="gene ID" value="STSP2_03231"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03231"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052794">
        <property type="term" value="F:exo-alpha-(2-&gt;3)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052795">
        <property type="term" value="F:exo-alpha-(2-&gt;6)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052796">
        <property type="term" value="F:exo-alpha-(2-&gt;8)-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010704497" evidence="2">
        <location>
            <begin position="21"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="545"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="708" mass="78932" checksum="A7E36085F03F8B7E" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ60</accession>
    <name>A0A1U9NQ60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_12</name>
        <name evidence="2" type="ORF">STSP2_02947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69750">
        <property type="protein sequence ID" value="AQT69750"/>
        <property type="gene ID" value="STSP2_02947"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02947"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="225" mass="25470" checksum="11052BEB386DF7B1" modified="2017-06-07" version="1" precursor="true">MDRITGQSAKARPKAFTLVELLVVIAVLAMLLAVLMPTLAAAKKRAKVTAVNAELKQIALALETYAHNNAGRFPPTYVSCMIQSHFYQLPRELTEGQYLPAKRKKHGPMSSAFEDRCNPDHTYKYIAPGDLVQNGDSVRRNGSWLYVPDGFPHNEKETGEYYNKPRESPVKYVVYSVGPNYDPEDEEVQNLRFPIPRKTWYDPSADKGAIVRIRLDNMKYTGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD5</accession>
    <name>A0A1U9NQD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulation protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nreC_3</name>
        <name evidence="5" type="ORF">STSP2_03346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70142">
        <property type="protein sequence ID" value="AQT70142"/>
        <property type="gene ID" value="STSP2_03346"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03346"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23995" checksum="2921CF1EA67B7AA6" modified="2017-06-07" version="1">MGIRILIADDHGIVRQGIKEIVSQHEDMEVIGEAADGLTTLKLVRDLKPDIVLMDISMPDLNGVETTREIKRDYPDVKIIGLSMHSAKKFISEMLKAGASGYLLKDTGFEELINAITVVSSGQNYLSPAITETVVENYVRNSPERPNSVFSTLTKRERQILQSLAEGKTTKQTAKDLFISPKTVEAHRLNVMNKLGIDNVAMLTKYAIQEGLTSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQI8</accession>
    <name>A0A1U9NQI8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR_3</name>
        <name evidence="12" type="ORF">STSP2_03287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03287"/>
    <dbReference type="REBASE" id="191342">
        <property type="entry name" value="PbaBD1IIIP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70085">
        <property type="protein sequence ID" value="AQT70085"/>
        <property type="gene ID" value="STSP2_03287"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03287"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="264"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1032" mass="118908" checksum="A8D44991F7020346" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQL5</accession>
    <name>A0A1U9NQL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69910">
        <property type="protein sequence ID" value="AQT69910"/>
        <property type="gene ID" value="STSP2_03110"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03110"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31766" checksum="8DAF5DAB635D441C" modified="2017-06-07" version="1">MSSAQQAFSTKNATLTNHHKPLSLTKDQTRAAIWASRLFLSRKKITPQTPKVLHYYALTLDSFQLPDGRPYTNTVSALQTLSASLDYARLLHLLPPNSIIEPSPYLKLIPQHKNPNSASGPYHVEIWAENTSAGYLFSHFAQQNNIPLIASPEIFTHTTYWHFARRAAHIRQPIKIIHLTDISSANSQPTSIVCMKIQQILQSYRLHRFTVNVISLTPDPNPLKLPSCPQNQIGKYQTAHPTLYELEAWHAIAPGAPLNMVRTCMKSLKNVPAGRTSRSHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQR9</accession>
    <name>A0A1U9NQR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="10" type="ORF">STSP2_03054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03054"/>
    <dbReference type="EnsemblBacteria" id="AQT69856">
        <property type="protein sequence ID" value="AQT69856"/>
        <property type="gene ID" value="STSP2_03054"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03054"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17976" checksum="E71603E192C9C97E" modified="2017-06-07" version="1">MAKRFTASRAQMKPDAKFNSILVSKFINCLMWDGKKSTAQKVFYDAMNIMDNKIKDESPLEVFETAINNVKPMLEVRSKRVGGASYQVPMQVKPKRQQALAFRWILAATRNKKGKPMSQRLASELLDAYRKEGTAMTTRENVHRMAEANKAFAHFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT3</accession>
    <name>A0A1U9NQT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase/pyrazinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03498"/>
    <dbReference type="EnsemblBacteria" id="AQT70292">
        <property type="protein sequence ID" value="AQT70292"/>
        <property type="gene ID" value="STSP2_03498"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03498"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="25052" checksum="224318D27EFF3E2B" modified="2017-06-07" version="1">MDITKLDKRKVLFWDIDTQYDFLKPDGKLYVPDSQPIIDRISRTRRLALDNGYSIVASTDYHSIDNEEISLEPDMQKTFPPHCMKGEPGAARVGDLGDLPVNYIESGVLNQPLVEDVCTRDQFHIVVRTDTVNMFDNPNTQLILKTVQPRLNIVFGVALDICVNHAVEELLKAGFGRIILLTDVTKAIDDEAGEKYLQSFQQRNVRLATLNEIEQELICTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQW1</accession>
    <name>A0A1U9NQW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03505"/>
    <dbReference type="EnsemblBacteria" id="AQT70299">
        <property type="protein sequence ID" value="AQT70299"/>
        <property type="gene ID" value="STSP2_03505"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03505"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="28279" checksum="7A9E126AE0FE7320" modified="2017-06-07" version="1">MGKSKCEIRVGTSGWHYKHWRGVFYPEELKTSEWFGFFAKHFDTVEVNNSFYKLPDEKTVKDWAEEAPKGFLYTVKANRYITHIKKLSDPGDALDNFYERMGHLGKTMGPVLYQLPPNLHKKMEKLRAFCEMLPKGHNTVFEFRHASWYDDDVLDVLDEFGCGFCVHDMGGVESPKERTGDVIYLRFHGTQGEYSGGYTDGQLSEWADWVKKHKKGIKAVYAYFNNDVEGNAVRNAMTLRDMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR59</accession>
    <name>A0A1U9NR59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">lnt</name>
        <name evidence="10" type="ORF">STSP2_03314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03314"/>
    <dbReference type="EnsemblBacteria" id="AQT70110">
        <property type="protein sequence ID" value="AQT70110"/>
        <property type="gene ID" value="STSP2_03314"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03314"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="560" mass="63036" checksum="A5784926DF62150E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR95</accession>
    <name>A0A1U9NR95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70325">
        <property type="protein sequence ID" value="AQT70325"/>
        <property type="gene ID" value="STSP2_03531"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03531"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11278" checksum="99D69739EEEA21CE" modified="2017-06-07" version="1">MDFLRTLEWMRLALCGDSCGVASRRFFYAGFRIGVRDDNLSRRWRWFGCMRFMDVQVFLLADAPGVSFSGPRIKSGVTGLSPLALTDRRVRAIDNRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRA5</accession>
    <name>A0A1U9NRA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiosulfate sulfurtransferase YnjE</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ynjE</name>
        <name evidence="3" type="ORF">STSP2_03354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03354"/>
    <dbReference type="EnsemblBacteria" id="AQT70150">
        <property type="protein sequence ID" value="AQT70150"/>
        <property type="gene ID" value="STSP2_03354"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03354"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="48716" checksum="48DF482483AAA8A9" modified="2017-06-07" version="1">MSNQGQVTTAELSKKLGKPHVKIVDTRPVEAYNGWRLRGEQRGGHIQTAKSLPAKWTSYIDLPDIVRSKGIEPDDEVILYGYDAQDCERPAKCFNRAGFGNISVYNGFLNEWSADDSLPMSRLERYKNLVSAQWLKDLITNTAAEYDNDNFVICHAHYRNPDAYTSGHIPSAIPLDTNWLESSETWNRRSPQELQQTLQNLGITHETTVILYGRFSFPKNSDSFPGSSAGQLAAMRCAAIMMYAGVRNIRILNGGLQAWLDEEFDLSTEEIKPKPVSSFGRDIPANPNVFIDTPQAKQVLRAEDQNLVSVRSWPEFIGKVSGYNYIEKTGRIPGAVFGNCGSDAYHMENYRNLDHTTREYHEIEQLWKQAGITPDKLNAFYCGTGWRGSEAFMNAWLMDWPRICVYDGGWFEWSSDPANPIEIGEPATSMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRM7</accession>
    <name>A0A1U9NRM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative CtpA-like serine protease</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03476"/>
    <dbReference type="EnsemblBacteria" id="AQT70270">
        <property type="protein sequence ID" value="AQT70270"/>
        <property type="gene ID" value="STSP2_03476"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03476"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="365"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="751" mass="83818" checksum="21F078E9DFD5FB57" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRT8</accession>
    <name>A0A1U9NRT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">STSP2_03442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03442"/>
    <dbReference type="EnsemblBacteria" id="AQT70236">
        <property type="protein sequence ID" value="AQT70236"/>
        <property type="gene ID" value="STSP2_03442"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03442"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13171" checksum="33C494B846F4E8FD" modified="2017-06-07" version="1">MMQITMIAIAGALGALGRYGAGLWAGRLLGTGFPYGTLIVNVAGCGLIGFFMHVGMTTDWLAREYRTAVTTGFLGALTTFSTFSYETVTHIEDGAWAAAAGNVSLNVVLGLAATFGGLFLARTIVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG29</accession>
    <name>A0A1U9NG29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00029"/>
    <dbReference type="EnsemblBacteria" id="AQT66891">
        <property type="protein sequence ID" value="AQT66891"/>
        <property type="gene ID" value="STSP2_00029"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00029"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12995" checksum="4B5004E32F3AF7B5" modified="2017-06-07" version="1">MSDNLISFLESGIRAESLRQRAISSNMANLNTAGYRRHEVKFEEELAKAMQAGKDPKNVEAEVFQPKTAPLNKMGNDVNLASEVGDMVKNSLRHKAFIRLLKGRYNRYEQAIKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGP1</accession>
    <name>A0A1U9NGP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxidoreductase YvaA</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yvaA_1</name>
        <name evidence="8" type="ORF">STSP2_00113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66975">
        <property type="protein sequence ID" value="AQT66975"/>
        <property type="gene ID" value="STSP2_00113"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00113"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="7">
        <location>
            <begin position="192"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT66975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="47133" checksum="2E78270E1B8247AA" modified="2017-06-07" version="1" precursor="true">MERNISTPRSFSRRDFIKATSAVSLAAVAGPASVFAAGEEKIRVGVIGCGGRGTGATIDCLRADPAVEVVAMGDLFQDRLDGSLRRLKKDFADRVKVTPETMFTGFDNYKKVCAIEEVDLIVTAAPPHFRPIHLEECVRQGKHVFMEKPVCVDAVGARKVIEASKQAKAKKLGIVAGTQRRHQASYIEAMKRIHDGAIGEIVGGQCYWNMGGLWVKEKKPEWSEMEWQCRNWLYFTWLSGDHIVEQHVHNIDVINWAMGGPPKKAMGMGGREVRTEDKYGNIFDHFAIEFEYDNGARVMSMCRQTPNTATRVSERLVGTKGVSDPRQWISGENEWRFSGEAKNPYVVEHADLIASIRAGEPLNEGQRVAESCLTAIMGRMSAYTGKALSWKWLVNASKLDLSPEAYEFGPVETRPAATPGKTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS3</accession>
    <name>A0A1U9NGS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein TolB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67133">
        <property type="protein sequence ID" value="AQT67133"/>
        <property type="gene ID" value="STSP2_00274"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00274"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040698">
        <property type="entry name" value="HZS_alpha_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18582">
        <property type="entry name" value="HZS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HZS_alpha" evidence="1">
        <location>
            <begin position="472"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="840" mass="93991" checksum="0FCACCA86587FA01" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW6</accession>
    <name>A0A1U9NGW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66984">
        <property type="protein sequence ID" value="AQT66984"/>
        <property type="gene ID" value="STSP2_00122"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00122"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29877" checksum="EF364D31BE0CEEA3" modified="2017-06-07" version="1">MKSKRKQKAFTLIELLVVIAIIALLLSIMMPALGMVKEKARAVICRSNIRQWGTLFALYTNDYNGTLPPHWSDNRTPGNPSGTWIISMESYYGGANVDDEQISVCPSTKKGKETEGATDPHTWIWEETASDGRIYRNSYAINNYASSTTSGIQGLWERTGQKQSNNIPLFMEGWRWGGGFSERHMSDDVPPTRDEITKSVNYPTGRYLVDRHDLAINVLFMDSHVEEVGFKALWDLKWHKTYDTNGDYPDWPEWMKNAKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGY1</accession>
    <name>A0A1U9NGY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67027">
        <property type="protein sequence ID" value="AQT67027"/>
        <property type="gene ID" value="STSP2_00165"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00165"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7265" checksum="05050095E130D04D" modified="2017-06-07" version="1">MHPREHGAKIKAAPWMTIGSNLCTNKCCIDFLNNTFSAEYSFCQYLILPVEAFFTVETVFLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH26</accession>
    <name>A0A1U9NH26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67105">
        <property type="protein sequence ID" value="AQT67105"/>
        <property type="gene ID" value="STSP2_00246"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00246"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20914" checksum="F4C50E1D7D06AB5C" modified="2017-06-07" version="1" precursor="true">MRMCLLFLVMVIFMGGCDNLRLAATEKMKQNAALHELTVAQAAETAKLEGVSEELCGLTEMAHSQSRAFVADYGMPAEYPVVNSLDDLLGENTQRLAEQAVNDSSRRLDPWGFADGILEIGIGIAGLAGGVWGVRAASFFAQARNKANALKEIIEGNEAFKAQDSQMSAEFKKAHRHQSRQTRKLVAEIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH47</accession>
    <name>A0A1U9NH47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67078">
        <property type="protein sequence ID" value="AQT67078"/>
        <property type="gene ID" value="STSP2_00218"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00218"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="29" mass="3451" checksum="B8D917E718979BAC" modified="2017-06-07" version="1">MISAENEPFFHNSGIFVQTPFIFCRYNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH83</accession>
    <name>A0A1U9NH83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">STSP2_00004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
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</entry>
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    <accession>A0A1U9NH96</accession>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    <sequence length="256" mass="28275" checksum="7A5EA5560E364537" modified="2017-06-07" version="1">MGLLAESRHQYILDKLRSLGRIQVASIASELGVTEVTIRRDLTQLQKQGLLKKTYGGAVLAGRPELNAPVNFRKTRNLSAKKTIGELASRLINDGDNIYLEAGTTCNEIIPHLTNHSSLTIIVNSLFLMRRLHDMTQHRIILTGGQYRPDRMDMIGPAAEATIAQLAGFKAFTGADDISLEAGISGADVVTVSFTKLVIKRASKVIFVGDNTKFDNPALYQIADINQLDYIVTNRDPGPNWRQTAREENVQLIYGE</sequence>
</entry>
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    <accession>A0A1U9NHA6</accession>
    <name>A0A1U9NHA6_9BACT</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">STSP2_00024</name>
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="350"/>
            <end position="406"/>
        </location>
    </feature>
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            <end position="482"/>
        </location>
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            <end position="337"/>
        </location>
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            <end position="224"/>
        </location>
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            <end position="287"/>
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        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT66886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="495" mass="53966" checksum="D622746F7E9FE035" modified="2017-06-07" version="1">MAEALTDLQNSAVEVTIGAFDAFCDDIASMFGIQASGCELEIETCAFKSLKKEFKRLTCVYSVKSSGALDGNFHIMLDQDALFTLAGVFVMLPDNIIDKNRKAGTEDDAKEHADALGEVGNLLVGAWDRFFREEMEGHEHFLQSGTFIGKPFMKSEEKISLAADEQVVAVGYEMTLDEYEPVKCAAVLPVSLFEEKQAEPETEQAVETQDEPEAKTEEKPQAKTEPADGQIAADSADNGASAEEKEDPEAEKQTVKTDEAAAEQKAVEASDSPEPEQPEEELKPEPAAAENAEQVEAEDEQIQTEQPDEEKTQKDGGPISQEIRRLTRTTSGVSTGDIAMLNNTPVADAMRTDVVWATQDETVEKVLASMQQNNAAYVLVGAEDSLGGIVSKSDIRAALSPYLNNVFAKYRREQDTATLQIKIKWFMSRPVRTIRPDAPLASAMDTMLKHSIRALPVADEKGVKGILTAFTVFDALLRDEDTSTAGQNTDVPPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHC1</accession>
    <name>A0A1U9NHC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67205">
        <property type="protein sequence ID" value="AQT67205"/>
        <property type="gene ID" value="STSP2_00348"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00348"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="541" mass="56850" checksum="472267739743B1FE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG7</accession>
    <name>A0A1U9NHG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00360"/>
    <dbReference type="EnsemblBacteria" id="AQT67217">
        <property type="protein sequence ID" value="AQT67217"/>
        <property type="gene ID" value="STSP2_00360"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00360"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="210"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="33216" checksum="4847F245C471F090" modified="2017-06-07" version="1">MINSMTGFGEAARELDGVIYTAELKSVNNRHLKTHVKLPDIVGFLADDIDKLLRAELRRGTVNFWIHAQNVAGEGLYDLDERVLENYITKIRSVAERSGSGGSFNVADLVTLPGVVKPVVPDEQQEQRLRETVMDIANQAVQKLEKMRQVEGKALEDDLLANCAAITDRCSQIDSRSDEVLKAYHEKLQKRVEELLSGSNFKLDEEMIAREVAIFAERSDIAEELTRLDSHIKQFEKCCKEVEHCGRRLDFLSQEMLREANTIASKASDAQVSQLVVDIKCMIDRIKEQVQNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK4</accession>
    <name>A0A1U9NHK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.312</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ligC_2</name>
        <name evidence="4" type="ORF">STSP2_00556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.312" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67412">
        <property type="protein sequence ID" value="AQT67412"/>
        <property type="gene ID" value="STSP2_00556"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00556"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050606">
        <property type="term" value="F:4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012550041" evidence="1">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="219"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="440" mass="48778" checksum="893E4F8486616033" modified="2017-06-07" version="1" precursor="true">MNRRDFIKSTSAATLGLGVMGLGSVAKAAPNEKVIVAVAGIRSRGNYLANKFAGLKNCEVKYVIDVDSRYLPSCAAGVEKTQGKKPQQISDFRKALDDKDVDAIVIATPDHWHAPMGIAALSAGKHVYVEKPCSHNPAEGELFVAAQKKYGKVVQMGNQRRSIGATQRMIKEIRDGVIGNPYFARTWYSRNRKPIGFGKEVDVPDYLDWDLWQGPAARTAYRSNVHPYNWHWFWRWGTGEALNNGTHELDIARWALGVEFPTKVTSLAGRYAYPDKDDWECFDTQNISIEFGGDKLITWEGISAGNTPINKQGRGVMILGDEGQIDYYADRYEVFDKNHNLVNKVDSVQADENADQTDTTDPGLKDNHAGNFIQAIRGVEKVNSPIDEGHKSVLLGHLGNIAARTGTMLECDAANGHIKNNKTAQALWSREYAPGWEPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK6</accession>
    <name>A0A1U9NHK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">pckG</name>
        <name evidence="12" type="ORF">STSP2_00230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00230"/>
    <dbReference type="EnsemblBacteria" id="AQT67090">
        <property type="protein sequence ID" value="AQT67090"/>
        <property type="gene ID" value="STSP2_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00230"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="10">
        <location>
            <begin position="245"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="272"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="624" mass="69866" checksum="27FB7E89AA4599DE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ0</accession>
    <name>A0A1U9NHQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67462">
        <property type="protein sequence ID" value="AQT67462"/>
        <property type="gene ID" value="STSP2_00609"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00609"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12956" checksum="7ED6F1462215573D" modified="2017-06-07" version="1">MAENKKKNKILDENILFDSPPSPAVLEVLYFNYLRKLRTQAWKTPDTPENFPRVSKAQTIETLSLAAETTLTQGVKPASDIIVDLGVKLGDWFVEAVSHIFIENQLEPQKQQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ3</accession>
    <name>A0A1U9NHQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ORF">STSP2_00598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00598"/>
    <dbReference type="EnsemblBacteria" id="AQT67451">
        <property type="protein sequence ID" value="AQT67451"/>
        <property type="gene ID" value="STSP2_00598"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00598"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28646" checksum="061F8D6CAA9525D4" modified="2017-06-07" version="1">MNKIGFIGSGNMAEALIKGIISANLYAPENVLVSDIRQDRLKYLAEEYGVQPASSNTELASQVDVLVLSVKPQNMAAVLEEIQDSLNDSAVVISIAAGITTERIAQFLGDVPIIRAMPNTPAMVDQGATAVVIRNTGPRQFKAGLDVFMAVGKVEVLEDESLIDAVTAVSGTGPAYFFLLMEELINVAIDMGLPADIAKELVFQTAKGAGLLAEMAYSRNETPGQLRERVTSPGGTTAAAMKVLKDLDFNGIMTKALTAARDRSRELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHV2</accession>
    <name>A0A1U9NHV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67503">
        <property type="protein sequence ID" value="AQT67503"/>
        <property type="gene ID" value="STSP2_00651"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00651"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="44" mass="5195" checksum="D013B2937DE7DF37" modified="2017-06-07" version="1">MERDRKAAEERFNEGVEFCNKGRYEECLNAFEEAIRLEPTNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI11</accession>
    <name>A0A1U9NI11_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67388">
        <property type="protein sequence ID" value="AQT67388"/>
        <property type="gene ID" value="STSP2_00532"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00532"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040843">
        <property type="entry name" value="RAMA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18755">
        <property type="entry name" value="RAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAMA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="114" mass="13011" checksum="8C7259541E81E884" modified="2017-06-07" version="1">MEKRSGIKTYDVSVSDLIDADLLQVRQKLYFRYAPRGMERKTYKAIVLEDGSITTLGQNFSSLSYAAIACIQDAGSERTTTNGWDAWKTKDGCSMAQVREEYLRVKEQQAEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI85</accession>
    <name>A0A1U9NI85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="synonym">tpi</name>
        <name evidence="12" type="ORF">STSP2_00787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00787"/>
    <dbReference type="EnsemblBacteria" id="AQT67639">
        <property type="protein sequence ID" value="AQT67639"/>
        <property type="gene ID" value="STSP2_00787"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00787"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="412" mass="44380" checksum="45D9A26AAEEBF5C6" modified="2017-06-07" version="1">MAKKTVADINVQGKKVLMRCDFNVPLDDNGNITNDARITKALPTIKHVLDGGGSLILMSHLGRPKGERNDKFSLAPVAKRLSELLGKDVVFAGDCIGEEVEQKAAGLKDGDVMLLENLRFHKEETIKDKAAKEDAELRKAKDDFAKQIAKLADAYVCDAFGTAHRDNASMYTVPCMMEDKPRVSGFLIEKEIKFLGDTVEAAEKPFVAILGGAKVSDKIGVIENLMRKVDTILIGGAMAYTFAKAKGNKIGKSLCEDDFVEKASTLVEEAKEVGCDILLPVDTVVAQEFKAHAENKVVEGDIEDDWEGVDIGPKTQELFADKLKNAKTIVWNGPMGVFELEPFDKGTKAVARAVADATSQGARSIIGGGDSASAVIGMGLEDKVSHVSTGGGASLEFLEGKKFKVFSILEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE0</accession>
    <name>A0A1U9NIE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe/S biogenesis protein NfuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfuA</name>
        <name evidence="2" type="ORF">STSP2_00494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00494"/>
    <dbReference type="EnsemblBacteria" id="AQT67350">
        <property type="protein sequence ID" value="AQT67350"/>
        <property type="gene ID" value="STSP2_00494"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00494"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9208" checksum="44BF65A3A53AE756" modified="2017-06-07" version="1">MCDNCGCGEKSFDAKVSEVIEQVRPMLQNDGGDIELVGIDEDNTVKVRLQGACRGCPGAAMTLKMGVERLLKERVPEVKEVVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIE3</accession>
    <name>A0A1U9NIE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapE</name>
        <name evidence="9" type="ORF">STSP2_00705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00705"/>
    <dbReference type="EnsemblBacteria" id="AQT67557">
        <property type="protein sequence ID" value="AQT67557"/>
        <property type="gene ID" value="STSP2_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00705"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="39453" checksum="FB6F906DCB83AE2B" modified="2017-06-07" version="1">MARSTADIGELRAAKVLRDYLEPLGIDCDVDCWDTCRANFTAHLGSNGDRPGLLFAGHLDVVPPGDAVWSHPPFEPAEVEGKMYGRGTADMKSGLAAVAAAIAEIKNEDTELAGDVIFTATADEETGSYGIKRFIEKRTPHLSRLQGIVVPEPTGLEIVTGHRGILWLEFRTHGKTAHGSMPELGVNAITRMLPLLNKLNGYELPADEDPMLGRSTLSINEIHGGKATNVVPDACSLKIDIRTLPQQSQEGLIEHFQQMVRKIGVEHADFDADIEVIKSVEALLTDSNCEFVKSLRRATEGKKPGIVSYTTDGPWLAELGVPVVIFGPGEPSACHKPDEYVELDQLERAKDHYKDLILECLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIK2</accession>
    <name>A0A1U9NIK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase A</fullName>
            <ecNumber evidence="3">3.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgpA</name>
        <name evidence="3" type="ORF">STSP2_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00765"/>
    <dbReference type="EnsemblBacteria" id="AQT67617">
        <property type="protein sequence ID" value="AQT67617"/>
        <property type="gene ID" value="STSP2_00765"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00765"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18061" checksum="F4EC7F480398D557" modified="2017-06-07" version="1">MLGIKRFLTSSFGLGWLPIAPGTWGSLGPVGIFALLYYLGVKPGPMRYAMIIVALLSSIICVLCSPASIKAAGRKDPGEVVVDEAAGQAITLMFILPSAYAMPQVAIAAGGSFLLFRLFDIIKPYPCKLLEKFPAGWGILADDLMAGLYGGIVLLLAQVVYLKVSDVTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIL4</accession>
    <name>A0A1U9NIL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Swarming motility regulation protein RssB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rssB</name>
        <name evidence="4" type="ORF">STSP2_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67761">
        <property type="protein sequence ID" value="AQT67761"/>
        <property type="gene ID" value="STSP2_00910"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00910"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20450" checksum="6E5D386350243B80" modified="2017-06-07" version="1">MSRNTTHVLLVEDDPAARRLIEKALSRADNAAYKLDMASDIGAAKALLLQKKFDAMILDLNLPDSRGIETVAAVRSMDQDIPIVAQSALDDQDIGLRCIEHGADYFLVKGDFMRRRLPRSIEYAKRHRDRKLSVDQSDPETSPDKQQEDNIQSRQLKSQLKKVKTSIAANHKSYEPLDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIN1</accession>
    <name>A0A1U9NIN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase YpeA</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ypeA</name>
        <name evidence="2" type="ORF">STSP2_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00795"/>
    <dbReference type="EnsemblBacteria" id="AQT67647">
        <property type="protein sequence ID" value="AQT67647"/>
        <property type="gene ID" value="STSP2_00795"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00795"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18859" checksum="8ADBF0E696339EBB" modified="2017-06-07" version="1">MTQLTNEDGRAEIRIRRAIIDDLAPIFYLGEKLFTAQDYSNLYRTWDEYEVTHLFNVDSDYMLVAESDGRVVGFAMGTTIEKTRTAWNYGHLIWLGVDPAYARQGIASQLFDEFRKLMEDAGVRILLVDTQADNEKAIGFFEQKGFVNPVDHVYMTLNLESEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIP0</accession>
    <name>A0A1U9NIP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="227" mass="24662" checksum="1AB37FCA29327CEB" modified="2017-06-07" version="1">MTEYSFTWLIWCRVLTAAFFLAQGFHTVAEAKIVIDDGQRHVIDDTESIFSDGVELDLGIFQDPSTHFDLVEGGSLLGLGVHGNATVTMTGGEVETDIVVTDNARVTISGGSIGARLANFSDNFIYLNGTGFQVVDQAGIETDLHYGDSLSDYVPFVQEVEFGIATNYYTGTIRGVLADGSIINNRFDIFRNSTFGGSGDIIVLPEPGTLILLSLGGFLFRRETVRR</sequence>
</entry>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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            <begin position="174"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
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                <person name="Sproer C."/>
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</entry>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67606.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01165"/>
    <dbReference type="EnsemblBacteria" id="AQT68011">
        <property type="protein sequence ID" value="AQT68011"/>
        <property type="gene ID" value="STSP2_01165"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01165"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="591" mass="64842" checksum="B749E061F2A60F6C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD8</accession>
    <name>A0A1U9NJD8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ORF">STSP2_00784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00784"/>
    <dbReference type="EnsemblBacteria" id="AQT67636">
        <property type="protein sequence ID" value="AQT67636"/>
        <property type="gene ID" value="STSP2_00784"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00784"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38778" checksum="072B1BA8047D0F91" modified="2017-06-07" version="1">MSYVRENIERMKGYTPGFQPEGLDVVKLNTNENPYPPSERVLEAVRGITAEQLRRYPQPLGDKFRIAASGVLGVEPDNIMCTNGGDDLLTIAFRAFCDEKRAVIFPGPTYSLYPVLAHIQDCAAWEVDFDDEELYDNLADANEALTIICNPNAPSGKQIEPAKIGELAERLDGVLLVDEAYADFAEQDCVGLVRELDNVMILRSMSKGYSLAGIRFGYCIASAELIGELLKVKDSYNVDAVAIEAATAAIEDQDYFRSNVMKVVAERQRLTKNLRELGFAVEDSSTNFVLAQISKPSAKDIYEELARRNIFVRYFDLPKLKDKLRVTVGTPEQNDALLGALKDITGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJH6</accession>
    <name>A0A1U9NJH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor CnrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cnrH_1</name>
        <name evidence="3" type="ORF">STSP2_01036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01036"/>
    <dbReference type="EnsemblBacteria" id="AQT67884">
        <property type="protein sequence ID" value="AQT67884"/>
        <property type="gene ID" value="STSP2_01036"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01036"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014331">
        <property type="entry name" value="RNA_pol_sigma70_ECF_RHOBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02989">
        <property type="entry name" value="Sig-70_gvs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="183" mass="21150" checksum="3E4449FFDEED42C4" modified="2017-06-07" version="1">MSHIDAHKNGEVDKGKRFVRLLMASEGRIYSYILTLVGNWSDAEDIMQDTAEVMWCKYDQSEPIENFTAWGISIARNKVLNYYRKKGNYRVLFNSDVFDSVAEDSARASSDIDFRVEALRNCLGRLGERDLRLIELRYEKGNTVKRIASYVGRPVQGLYKTMGRIHENLLECIRRALAREDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJK8</accession>
    <name>A0A1U9NJK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01080"/>
    <dbReference type="EnsemblBacteria" id="AQT67928">
        <property type="protein sequence ID" value="AQT67928"/>
        <property type="gene ID" value="STSP2_01080"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01080"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="220"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="438" mass="49733" checksum="2BD95FC82D413BDB" modified="2017-06-07" version="1">MKRIAEKKLLAWINSYRRKPLVIRGARQVGKTWLVENCLAKQFEKYVKIDLEKQPQFHAAFEGDLTPNRMLEVIELHAGRITPGKTLLFIDEIQGYPRAITALRYFYEELPELHVVAAGSMLEFAFGGISVPVGRIEYLHITPMTFYEYILAIGNEIIAERLLEHPKDHSDALVEAIHQHLRDYFFIGGMPEAVEAYRDTRSKLESYKIHSQIISSYREDFAKYRPSVDYACLDGVLDSVARSTGQQIKYTQLYEHASGVTNHKAFDLLCKAKLLNRISSANPSGLPLGASQGKRFKASMLDIGLMQHMCGIDPSIAVGKENLLSIYNGQLAEQFVAQELLAWHTDKLFYWSRTAKSSNAEVDYLTVRDSTIYPIEVKSGPAGRLRSLHLCLEAYPNCPQGWVLQDGPYQELPSQKLIFWPLYATPHLGNRQQLPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK38</accession>
    <name>A0A1U9NK38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">STSP2_01332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP J family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01332"/>
    <dbReference type="EnsemblBacteria" id="AQT68177">
        <property type="protein sequence ID" value="AQT68177"/>
        <property type="gene ID" value="STSP2_01332"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01332"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010055">
        <property type="entry name" value="T2SS_protein-GspJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11612">
        <property type="entry name" value="T2SSJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT68177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26738" checksum="0F67DD213361B0F4" modified="2017-06-07" version="1">MRDKRAQSGFTLVEVTIAAVIGSFIAVIAIGALRAAASSRENVEKFLSVNDELRFASNLIRRDIQNVYRSANYGNMQFLGSVSEDSETPSSVLNMKIVSTQKARPQRPESDVYVVEYFIMTEEEKNYLMRRYCPVVGHEEPEETQGGILIPVGENIVGFEVRYFDGTEWLMDWPDTQESLPGLVEVTLAASLSQDSSPEDIASTSFMLSFPRSGESSQQDSVDMNADQQENVAEQRGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK61</accession>
    <name>A0A1U9NK61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68311">
        <property type="protein sequence ID" value="AQT68311"/>
        <property type="gene ID" value="STSP2_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01470"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="243" mass="27751" checksum="502E8DCB407E81EC" modified="2017-06-07" version="1">MIRQTHQPGRKAILYARFSPRRNADQCESIETQFELCEDYCSKNQIEIVARFSDKAFSGSDEDRPGLWAAMNALKRGQCLVVYRLDRLARSVYLSDIVERTVKKKGASIVSISGEGTWADSDEDWLVRKILQTLAEYERKVTAARTKAAMLRHQANGKRMSKHPPYGFAIDPADPDRLIPSQAEQKVIQRIIILRESGLPLRAICRQLESEGIRCRNSSWHHTKLQRILQRVDASASNLSRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI7</accession>
    <name>A0A1U9NKI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore protein SP21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hspA_2</name>
        <name evidence="4" type="ORF">STSP2_01616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68452">
        <property type="protein sequence ID" value="AQT68452"/>
        <property type="gene ID" value="STSP2_01616"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01616"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16323" checksum="C6F92F7C052A03BA" modified="2017-06-07" version="1">MYRFRHVHYSLRDSGAERTTQLHHHQIHTLFHELIHKPWGCGTWEPPMDILETENEYQILVDLPGVAQDHIQVSLEDDILVITGTKPPPGSNNIIIHLSERNCGDFTRTVQFQTPIDPDKLTADLQNGVLKINISKNGGESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ0</accession>
    <name>A0A1U9NKJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-glucosamine 6-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.136</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">wbpA_1</name>
        <name evidence="5" type="ORF">STSP2_01484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.136" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01484"/>
    <dbReference type="EnsemblBacteria" id="AQT68325">
        <property type="protein sequence ID" value="AQT68325"/>
        <property type="gene ID" value="STSP2_01484"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01484"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047004">
        <property type="term" value="F:UDP-N-acetylglucosamine 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="333"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48187" checksum="711A10F01D702060" modified="2017-06-07" version="1">MLLRVVSGMNETMQKKIDDRSAKIAIIGLGYVGLPLAVEFGKIFSTIGFDINSDRIEELENGHDRTREVESEKLKAADKLTYGSDLESIKDADIYVVTVPTPIDKYKKPDLTPLIKASTTVGKVLSKGNIVIYESTVYPGCTEEDCVSVLEANSGLKFNTNFFCGYSPERINPGDKEHTVTKIKKVTSGSTPEIGQVVDSLYKTIIVAGTHLAGSIRVAEAAKVIENSQRDINIAFVNELSKIFNLMGIDTIEVLEAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSLGYHPEIILAGRRINDGMGSHVASEVVKLMIQKGHRIKGSKVLVLGITFKENCPDIRNSRVIDVIEELKSYGCELTVHDPWADPEEVKEEYGIQLKEVPTDQKDFDAVVIAVAHNQFKQIDFNTFDHGQIVVYDLKRSLATKIDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ2</accession>
    <name>A0A1U9NKJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemin importer ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01190"/>
    <dbReference type="EnsemblBacteria" id="AQT68036">
        <property type="protein sequence ID" value="AQT68036"/>
        <property type="gene ID" value="STSP2_01190"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01190"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="3"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="420" mass="48210" checksum="BD3A560B07A04BF6" modified="2017-06-07" version="1">MHKVTSIKIDNLWGEVCFKFDFFQDVTFLIGVNGSGKTTIINLIAAALSADFQTLDRIHFDSITIELSETDDGFKPFVYVIKDRERKSPCPAINYKIVKGKDNEQLFSLDDFVEDRLRRRMSSRHYYYQRRLTRGILSELKSLVNLNWLSIHRGALDADEETYESSVDQKLDEVCSQLSKYFSVLSSEIAEEIEDFQKDIIVSLLVSGNDFDEVVSLVETFNMSEEAKKLVEIFTKLNIAKEEASKENIYKRCRKVKTTLQQMIDGKLDWKDMAVLLNAYRSHKVVEDWNKLLEEQAKILTPRKTFVTVLNDLFTTKDIRINERNEVEGVTKSGKVLAANNFSSGEKQLLIMLGEALLQESKAWVYIADEPELSLHVSWQEKLVSNLLTLNPRAQILCATHSPDIVSVYSDRVYKVGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKQ6</accession>
    <name>A0A1U9NKQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01678"/>
    <dbReference type="EnsemblBacteria" id="AQT68513">
        <property type="protein sequence ID" value="AQT68513"/>
        <property type="gene ID" value="STSP2_01678"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01678"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="33064" checksum="3EEA371A0C2B1E20" modified="2017-06-07" version="1">MKTYLDCVPCFVRQAIDGCRLFTDDQEIHEKAVREVLRMASEMDLDQNPPAMGKEIHRLLRELTGIRDPYEDIKKHFNELAMSWYPKLKKRVENADDPLEMAVRLAIAGNIIDFGVQASIENDMVESTVEECVTGEFDHHLVEELAAAYADADSVLYLGDNAGEIVFDRILIEQLGPEKITFAVRGGPIINDITMVDAEYAGLTGIVEVIDNGDNAPGTILQSCSESFRDHFNRADMVIAKGQGNYETLSEVDKDVFFVLKAKCPMIAHHLGCEVGRMIFQRSSGRYKDRAVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX1</accession>
    <name>A0A1U9NKX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-inositol 3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.250</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshA_1</name>
        <name evidence="3" type="ORF">STSP2_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.250" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01760"/>
    <dbReference type="EnsemblBacteria" id="AQT68592">
        <property type="protein sequence ID" value="AQT68592"/>
        <property type="gene ID" value="STSP2_01760"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01760"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="140"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="252"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="441" mass="49504" checksum="D6D426AB241FB39F" modified="2017-06-07" version="1">MLGWEFPPFISGGLGTACYGLTKAMSQQGTEVLFALPKAVDTSSSTHVKMLSPRGNVKKRTYYVPGEPLEDILTNVEFRKIESLLEPYSTPEEYHERYEQIIRNKRSTSRLVEEWYEDTTEAAQGQKANYGEDMYTEVHRYAYSAARLAAGEDFDLIHAHDWMTYPAGIAAAAQTGKPLVIHVHSTEFDRSGEHVNQLVYDIERAGMHAADRIIAVSHLTRNIIISRYGVEGEKVEVVYNGVERNGQPKLPSRVGIRRNEKIVLFLGRITMQKGPEYFLHSAKKVLSVMPDVKFVMAGSGDMMEKTIEMAAELGIGNKVLFTGFLRGPDVQRVYEMADLYVMPSVSEPFGIAPLEALNYDVPVLISKQSGVSEVLTHALKVDFWDTDEMANKILAVLKYRPLQMTLKEHGNFEVRKLKWEDAAAGCNRVYQQVVTGAKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL46</accession>
    <name>A0A1U9NL46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA1_1</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">STSP2_01797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01797"/>
    <dbReference type="EnsemblBacteria" id="AQT68629">
        <property type="protein sequence ID" value="AQT68629"/>
        <property type="gene ID" value="STSP2_01797"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01797"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="421" mass="45451" checksum="88B994DA92E4CA3A" modified="2017-06-07" version="1">MSSKANAIIAQSGGPTTAINSSACGAIEAAMKSDKIGRVYGATNGILGVLQEDIFDISSENPKTISMLKRTPAAAIGSCRYKLKSLEESKEDYERILDVFKAHDIHYFFYIGGNDSMDTADKVNKLASETGYDLTCVGIPKTIDNDLACTDHCPGYGSVAKYVATCAMEAGKDTEALYTTDTCTILEVMGRNAGWIAASAGLARREPEDAPHLIYLPEVAFEYDKFVSDVKGVLNDFKRVFIVAGEGLRDKDGEYITSDTGSFSKDSFGHKQLGGVAETLKDIVEREVGIKARFNKLGTNQRSAMHFASLTDIEESYMCGNAAVEAALSGVSGKMVTLVREDGSDYSCTTGLANLSDVANGEKIVPREFINEAGNGVTDAMLDYVRPLVQGEAPVSINEDGLPVFMRFERKPVDKKLPSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL76</accession>
    <name>A0A1U9NL76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnrH_2</name>
        <name evidence="5" type="ORF">STSP2_01648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68484">
        <property type="protein sequence ID" value="AQT68484"/>
        <property type="gene ID" value="STSP2_01648"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01648"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="201" mass="23327" checksum="4E5C3C9851E47A5B" modified="2017-06-07" version="1">MYDELSQLSDAELAIKAGAGCRRSFEVLIDRYSARLLAFISSRVALREDAEDITQDTLIKAYVNMAKYNPRYRFSTWLFSIGYKTAVSHYRRSKTRQLKINHDKETPPPEQQLQVEDEAQNIWKLAKGLSRNQYEALWLRYNEQMQISEIANVMGKSKVHIKVLLHRSRNKLAQMRLEQDQANTSPVLSSKDTGIAMNWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB5</accession>
    <name>A0A1U9NLB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">asrB</name>
        <name evidence="4" type="ORF">STSP2_01454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01454"/>
    <dbReference type="EnsemblBacteria" id="AQT68296">
        <property type="protein sequence ID" value="AQT68296"/>
        <property type="gene ID" value="STSP2_01454"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01454"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30786" checksum="D4471D9FE7856263" modified="2017-06-07" version="1">MCDCCSSKKDIYLPELATVKKRKLMNGTELYLLIQLDSGEELGHKPGQFVEVSIAGIGECPISISSSPTQKGGFELVVRNAGSVTKAIHKLKVGDKVGIRGPFGEGYHIDQLKNRNLICICGGLGLAPQRSLINYILDNPSDFGTLTVLLGTKCYPQRFFREELAKWAEGDDMTFKETVDEEHDCWTGNVGVVTTLIPKVESHLKDSAVLVCGPPVMYKFVLMALEEYDIPHDDIYVNLERRMKCGVGKCGHCQINGEYVCQSGPVYRYSEIGAMPEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC9</accession>
    <name>A0A1U9NLC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68719">
        <property type="protein sequence ID" value="AQT68719"/>
        <property type="gene ID" value="STSP2_01891"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01891"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6535" checksum="F0B2966D468102FD" modified="2017-06-07" version="1">MRAALREDKTLVQLASEFDVHPNQITKWKRQVLDTLPEVIILQTAIEQNNNICQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD6</accession>
    <name>A0A1U9NLD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68380">
        <property type="protein sequence ID" value="AQT68380"/>
        <property type="gene ID" value="STSP2_01540"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01540"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22652" checksum="CC5437AC555A8AC8" modified="2017-06-07" version="1">MIATRQQAIAFATRVIVLILLVLAFASLIKCLGIFAGVLMIGPLNETDSSGFLLDLVLIGGIAQSVAPVLLAITALLLSRRTADLLANRTLGADTEEAPLVLAALLVLRSIGILLLFRVLYQNFNILLRYAYGLWAKNLLVERPEIKTAVREDPQIAAQLAELGSYSLDPKMLTAEMVTMVVYGLLAWYCLYKGRIIISFLTRAGCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE3</accession>
    <name>A0A1U9NLE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbsR</name>
        <name evidence="2" type="ORF">STSP2_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68762">
        <property type="protein sequence ID" value="AQT68762"/>
        <property type="gene ID" value="STSP2_01934"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01934"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="389" mass="43023" checksum="05AF778F49DAC71F" modified="2017-06-07" version="1">MVSNSSLDKIQLDKRPKKALPLYEQIRSQVNSRIEDKSLKPGDALPSIAHLSKQWDVTYRTIKSAYELLEQDGVVTFKAGKGVVADSDRMLDNQGKTLSVTFVSCHLDDPYYALASTGIRRFALEKGLELTTIDVGNSKRRFINAISSPGQDVDGMLILPFEVSGYESAVQKTIEAGRKVVFVDRDLPNVNASYVGVDHFSVAFQATSHLLAVHDRPVYYLAFVDKPSGAREWFKGWRSAMQSYNHFNSLDRYIIDLAIDESELAGTIDVGLEYSIFAARRLFQTQKEEKYSIFAGNDFIARGVYIAAEELGLEIGKDVFLVGSNDMPFAAKMEVPLSSVHPIPSVEHIGYQAAKVLYEQLTGTIGNSVRQLIPVELVARASSVGPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLE7</accession>
    <name>A0A1U9NLE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CysJI operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL</name>
        <name evidence="3" type="ORF">STSP2_01732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01732"/>
    <dbReference type="EnsemblBacteria" id="AQT68564">
        <property type="protein sequence ID" value="AQT68564"/>
        <property type="gene ID" value="STSP2_01732"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01732"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="34742" checksum="1B8FC02FD3C97AFB" modified="2017-06-07" version="1">MQIDTIRIFCDLVELKNFSRTAEKHGLSQSAISQQLAQLEMDHNCQLINRKTRPLTLTEQGQCFYHACQDILDRYDKLVSELKNLSRSHTTIRFAAIFSIGMHTLQPYVKRFMARFPQINLRIDYMDAKQIYDGILRGDLDLGAVAVPIESRSLNLVPFVDEPLVMVCSPDNPLAKEPVIDIHKLQGKDFIAFEKGLPSRKFIDNILDRYDVMPKTVMEFDNIETIKRAVEINSGISILPETTINTELREQKLATIAFTNENFFRPTGIIVRKNRSTTKAMKYLLELLGNGQVRNHANKSRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLJ4</accession>
    <name>A0A1U9NLJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01988"/>
    <dbReference type="EnsemblBacteria" id="AQT68812">
        <property type="protein sequence ID" value="AQT68812"/>
        <property type="gene ID" value="STSP2_01988"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01988"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012843869" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="310"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="975" mass="107066" checksum="43107A2DFBCB76D3" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLN7</accession>
    <name>A0A1U9NLN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin A1 protease</fullName>
            <ecNumber evidence="3">3.4.24.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iga_2</name>
        <name evidence="3" type="ORF">STSP2_01566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.13" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01566"/>
    <dbReference type="EnsemblBacteria" id="AQT68406">
        <property type="protein sequence ID" value="AQT68406"/>
        <property type="gene ID" value="STSP2_01566"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01566"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323963" evidence="1">
        <location>
            <begin position="40"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="846"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1763" mass="185739" checksum="F91386D1BBB4449B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU6</accession>
    <name>A0A1U9NLU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ptsI_2</name>
        <name evidence="20" type="ORF">STSP2_02055</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02055"/>
    <dbReference type="EnsemblBacteria" id="AQT68879">
        <property type="protein sequence ID" value="AQT68879"/>
        <property type="gene ID" value="STSP2_02055"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02055"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="253"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AQT68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="578" mass="64292" checksum="34C323230AA15D60" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX5</accession>
    <name>A0A1U9NLX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">lpxK</name>
        <name evidence="14" type="ORF">STSP2_02129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02129"/>
    <dbReference type="EnsemblBacteria" id="AQT68952">
        <property type="protein sequence ID" value="AQT68952"/>
        <property type="gene ID" value="STSP2_02129"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02129"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40724" checksum="61EA8A4AB3296F41" modified="2017-06-07" version="1">MNQNAFRNFIGGKRGLVGKLAYLFLRLLSGLYRLAISVRNFCYNKGLFTSNRAEVPVISVGNLTAGGTGKTPLVIWICKWLGANKFSCGVLTRGYKAKQGKFTDEPAIIAKSCPDAKIVINPDRTEGAKMVVEDYRVKSLVMDDGFQHRKLRRDLDIVVLDATCPFGYGHMLPAGLLREPIKNLRRADLVVITRSDQIEDQAVNDIIHKVRSIAGDVPVAKAINKYPYAKKFGGKIIDFDGLKERKIFAFCGIGNPCAFVDHLEAVGFSVVGRKVFNDHYEYEKEDLKHIYEEAKYCGADLVLTTLKDWVKASLLMKPREDMDFAYLALELDFIEGQDKVESLLRRTVKEGQSQQMREKDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM02</accession>
    <name>A0A1U9NM02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-binding ATPase YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ychF</name>
        <name evidence="2" type="ORF">STSP2_01681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01681"/>
    <dbReference type="EnsemblBacteria" id="AQT68516">
        <property type="protein sequence ID" value="AQT68516"/>
        <property type="gene ID" value="STSP2_01681"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01681"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="261"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="346" mass="38107" checksum="E6281C14677AF793" modified="2017-06-07" version="1">MKVALVGLMQSGKSTILSAISGKPVSPEMMNIHEEVVPVPDERLDWLTELYKPKKTVPGTIDCLDLPGMSFADDSGRAAARRLFDQVRTVDMLVLVVGAYRGSDAASELSELKTEFLLADLELVTTRIERLEKQVHKPSKTQAKDKAELALQLKLQEALENEKPASTVIKTDEDYALVKSLGFLTLKPLMVVMNVSEDDLGKEFDLSEVAGEDMEVVAMCAVVESEIAQLDDESKAEFMADYGIEEPAAHKFVQSCYSTLGLISFLTVGPDEVRAWPIEKGTTALDAAGKIHSDIKRGFIRAETIAYEDLKELGSEKECKAKGKARLEGKNYVVQDGDIINFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM14</accession>
    <name>A0A1U9NM14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02051"/>
    <dbReference type="EnsemblBacteria" id="AQT68875">
        <property type="protein sequence ID" value="AQT68875"/>
        <property type="gene ID" value="STSP2_02051"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02051"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="237" mass="27126" checksum="8F86DD29A5A8A5D0" modified="2017-06-07" version="1">MRALKNFRTYFLRGLAALLPTIVTLWIFFQSYMFVENRVSVHVNRWLVQTILLFTDRYSKEFLTDFWVHGPGKITGFFVAIVGVVFIGAFLASVVGRSFWHVIERTLMRAPLIKKVYPFVKQITDFLLTQKTLSFTRVVALQYPRRGVWSVGMVTGTGLKTISKAKNKEFLTVFVPTSPTPFTGYVIMTPRDETIELDMTIEEALRFTISGGVITPSDRETFKQLSESDQKAIDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM18</accession>
    <name>A0A1U9NM18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="11">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glmM</name>
        <name evidence="11" type="ORF">STSP2_01701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01701"/>
    <dbReference type="EnsemblBacteria" id="AQT68536">
        <property type="protein sequence ID" value="AQT68536"/>
        <property type="gene ID" value="STSP2_01701"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01701"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="163"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="266"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="392"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="456" mass="48376" checksum="48AC28B8A7143D06" modified="2017-06-07" version="1">MARELILGISGMRGIIGENLNANTAVDYGCAFGTFLQEKFDRDDMKVCIGRDSRVSGSMIFSAVASGLCSVGIDVIDLGIVTTPGVGLMVRHLECVGGVVITASHNPIEYNGIKLLTSEGVAPPKDMAESIIEVYKKQQFNLVDSIACGAVSRNVQTHDLHVGKVLDIVDTDAIATRNFKAVLDSVNGAGGTAGRMLLDKLGCEVTAINAEPTGIFAHTPEPTKENLVGLCDEITKAGADIGFAQDPDADRLAIVDENGVYIGEEYTLALCAKQVLGKMKGKTAANLSTSRMIDDVAGELGCEVIRTAVGEANVADAMIKNNCIIGGEGNGGIIDLRVGPIRDSLVGMALVLQLMADSGKTVSELVGEIGAYHVEKSKFEADKQQAAAIIEEAKKAFPDAEINTVDGCRFDFSDGWVHLRTSNTEPVMRLIVETETPEAAKRYVEKVDAIRDKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM40</accession>
    <name>A0A1U9NM40_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">STSP2_02157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02157"/>
    <dbReference type="EnsemblBacteria" id="AQT68979">
        <property type="protein sequence ID" value="AQT68979"/>
        <property type="gene ID" value="STSP2_02157"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02157"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="323" mass="36548" checksum="3E732E324E6E970C" modified="2017-06-07" version="1">MRVLSGIQPSGKLHIGNFFGAMRQHLQLQADNEGFYFIADYHALTTNPQADELRQRCLDVAMDYLALGLDPEKTVFWRQSDVPEVTELAWILSCVTPMGLLQRCTSYKDKVAQGLSPNHGLFAYPVLQAADIVAFDSECVPVGQDQKQHIEVTRDIAQRFNNMYGEVFVLPDEHILESVAVVPGVDGRKMSKSYDNTIEIFEPENKVKKKVMRIKTDSTPVEEPKDPDQCSIFAMLKLVAEKDELAEWREKYEKGGTGYGTVKKRVVELLHDYFRPYRNKRAELEDNQDYVKKVLADGAERARAVARTTLDKVRDAVGMGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM64</accession>
    <name>A0A1U9NM64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6067 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02200"/>
    <dbReference type="EnsemblBacteria" id="AQT69021">
        <property type="protein sequence ID" value="AQT69021"/>
        <property type="gene ID" value="STSP2_02200"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02200"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045711">
        <property type="entry name" value="GH123_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19543">
        <property type="entry name" value="DUF6067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010714648" description="DUF6067 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6067" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114060" checksum="2BDFB94590240BCA" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM68</accession>
    <name>A0A1U9NM68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69003">
        <property type="protein sequence ID" value="AQT69003"/>
        <property type="gene ID" value="STSP2_02181"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02181"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="PTHR31544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="2">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="641" mass="73615" checksum="3EEA04CA106FAB14" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD8</accession>
    <name>A0A1U9NMD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68967">
        <property type="protein sequence ID" value="AQT68967"/>
        <property type="gene ID" value="STSP2_02144"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02144"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="524" mass="59701" checksum="1E6DBEFB393466C8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH6</accession>
    <name>A0A1U9NMH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular endo-alpha-(1-&gt;5)-L-arabinanase 2</fullName>
            <ecNumber evidence="5">3.2.1.99</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abn2</name>
        <name evidence="5" type="ORF">STSP2_02300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02300"/>
    <dbReference type="EnsemblBacteria" id="AQT69113">
        <property type="protein sequence ID" value="AQT69113"/>
        <property type="gene ID" value="STSP2_02300"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02300"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="316" mass="35814" checksum="3BDC7E7D9F3A8993" modified="2017-06-07" version="1">MTLTYENPVWKGYLADPHILYTDGSYYAVGTGQTDDGKHFPILKSDDFENWEFVGGALEPLNEPQMDLYWASEIAERDGKYYLYYAGDMKMRVAVADRPEGPYKDAGVLLFPDLEFSIDGHPYKDPVSGKWYLFFAKDFFDKKPGTALAVVELGEDMISTVGPVHTVLRAFADWQIYERNRNWYDKHWPAWYTVEGPAVLYKDGKYYCFYSGGNWQTPEYGVGCAVSDTITGPYKDPWSSEGASVLSGQNNELIGPGHNSVITAPDGKTWFIIYHSWNSERTARQMCIDPLEWTADGPKAYQPSRGEKTVTIPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM8</accession>
    <name>A0A1U9NMM8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="5" type="ORF">STSP2_02346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
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        <property type="protein sequence ID" value="AQT69159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AQT69159">
        <property type="protein sequence ID" value="AQT69159"/>
        <property type="gene ID" value="STSP2_02346"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02346"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36539" checksum="94086618E527BF66" modified="2017-06-07" version="1">MRIAVDAMGGDHAPDEIVKGVLEARKCLDKEDELVLIGVKEKIEPHLPSKWRFPSGLSVVDAPEIIGMDEAPVEALRKKKKSSIALMAKMAASGEFDTIISAGNTGACVAACQLRMRNLEGVNRPGIAVTLPTFGGPVTVCDVGANVACKPINLYQYAVMSSVYARRMLGIENPRVALMGIGAEAGKGNTLVKRTRELLDADENINFIGNIEGRDIFDGTCDVAICEGFVGNVVLKLTEGLVDGLFRAIKQELLDEGLRLAMKFKPVMMRIYQKYDYHEYGGALLLGVNGNSIICHGTSKSRTIKNAIMASKKFVNMEINEAIVEYLSTSTVRPNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ3</accession>
    <name>A0A1U9NMQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02380"/>
    <dbReference type="EnsemblBacteria" id="AQT69193">
        <property type="protein sequence ID" value="AQT69193"/>
        <property type="gene ID" value="STSP2_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02380"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012504946" evidence="2">
        <location>
            <begin position="24"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="298"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="458"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="642" mass="68862" checksum="FB83296525E7DD00" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS4</accession>
    <name>A0A1U9NMS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GspH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_02077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02077"/>
    <dbReference type="EnsemblBacteria" id="AQT68900">
        <property type="protein sequence ID" value="AQT68900"/>
        <property type="gene ID" value="STSP2_02077"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02077"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="10">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18323" checksum="F958AC36CAE03F43" modified="2017-06-07" version="1" precursor="true">MVIDRRIDLTTCRSGGFTLMEILMVVVIISVAAVIAVPMMGSAATSQIKSAGNVLAADIEYAKSMAISRQKNYSIVFDAASESYSIEDDSGNTITHPVRGGNYTTQLSSGSDLDRVSISTANFDDTQTLTFNYLGSPFNGDGTALNSGQVVLSADELTMTISVEPVTGYVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS5</accession>
    <name>A0A1U9NMS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)-translocating NADH-quinone reductase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02207"/>
    <dbReference type="EnsemblBacteria" id="AQT69028">
        <property type="protein sequence ID" value="AQT69028"/>
        <property type="gene ID" value="STSP2_02207"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02207"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="590" mass="63028" checksum="6CC58373C20BDBEB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMX8</accession>
    <name>A0A1U9NMX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69094">
        <property type="protein sequence ID" value="AQT69094"/>
        <property type="gene ID" value="STSP2_02281"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02281"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="972" mass="110974" checksum="E0517D32A8038033" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY5</accession>
    <name>A0A1U9NMY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02462"/>
    <dbReference type="EnsemblBacteria" id="AQT69273">
        <property type="protein sequence ID" value="AQT69273"/>
        <property type="gene ID" value="STSP2_02462"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02462"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012685381" description="Cytochrome_C554 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="3">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="629" mass="69266" checksum="7F4B045CE317C661" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN56</accession>
    <name>A0A1U9NN56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69341">
        <property type="protein sequence ID" value="AQT69341"/>
        <property type="gene ID" value="STSP2_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02530"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="344" mass="38795" checksum="13B420E070EE3449" modified="2017-06-07" version="1">MTQKQWETLLRTINGELIEPMPVGFIIDSPWLPEWNGIDKLEYFTSDTAWFETNLRAVKEFPDVLMLPGFWAEFGMCTEPSAFGAKCSWYEHELPYADRIISGPEQIDGIKKPKATADGLAPFVLKKLKRYEDDIQNQGHAIRFAIARGPLNIASFLMGATEFLMGLRTDTDRIHRLLRIVTDYTKDWLLLQKEQFNTIDGIFLLDDIVGFCGEPDFKEFAQPYLTELFNCFDASVKFFHNDADGSGCAPHLAQMGVNLFNYSFMHSIQQMKEWTNNEVTLLGNIPPRDVMAIGMPDDVKIAVDTALSDVQDRTKIILSCGGGMVGGTPSRNITAMTEQVAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC8</accession>
    <name>A0A1U9NNC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02427"/>
    <dbReference type="EnsemblBacteria" id="AQT69238">
        <property type="protein sequence ID" value="AQT69238"/>
        <property type="gene ID" value="STSP2_02427"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02427"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02522">
        <property type="entry name" value="GT_2_like_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04283">
        <property type="entry name" value="glyco_like_mftF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27238" checksum="3D586275ACB19BBB" modified="2017-06-07" version="1">MNEHQRKTGKSLNDEDNCRISVIIPVLHESAVINETVQHVFSIDGSEDCEVIVADGSDNADTLGVIKDGRITKMQSSPGRAIQMNAGANAACGNVLVFLHADTFLPKNAFTVIKNAISKQQYAVGAFKLGLDSDKLTMKIITALANLRNRILRIPYGDQAIFIRRELFEELGGFPAIPLMEDIELMKRLKRKGCKVFFSKAKVTSSARRWQKEGPWRCSARNLIISAMYHLGVPAERLVRFYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNF8</accession>
    <name>A0A1U9NNF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE_1</name>
        <name evidence="11" type="ORF">STSP2_02457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02457"/>
    <dbReference type="EnsemblBacteria" id="AQT69268">
        <property type="protein sequence ID" value="AQT69268"/>
        <property type="gene ID" value="STSP2_02457"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02457"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35599" checksum="FF362249AA6A5EB5" modified="2017-06-07" version="1">MSKDKQEVNAFSFPGSDIANLQRFRKEAMATIFHVFIVHEDREYAGQAAWEAFDVLDDLEQHFSRFIANSDISQINRLGEGESVVVSLPTFECLQQAKDMYERTFGAFDVTVGTLYKAWLREDKSIKMPGREELEFAREHTGADKIKLNEESFTVTLEEAPLSVDLGGIGKGFAIDRMMEVLREWEVESAMISGGGSTVLASGAPAGLDGWPIKVRSPLERSHTLTKLDLCGQAFSGSGIIKSQHIIDPRKGMPVSSVLSAWASAENGAFADALSTAATVMSRDEMRKYCEKHRGAMLMTAVKNIDKPGDVEMFKAGCWPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG9</accession>
    <name>A0A1U9NNG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein GsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiC</name>
        <name evidence="7" type="ORF">STSP2_02564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02564"/>
    <dbReference type="EnsemblBacteria" id="AQT69375">
        <property type="protein sequence ID" value="AQT69375"/>
        <property type="gene ID" value="STSP2_02564"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02564"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="312" mass="35069" checksum="835156A06C24386B" modified="2017-06-07" version="1">MIAYVIRRLLYCIPIVFGVLVVTFLLFNVIRGDVSMEYAGKNATPETIEEIREELGLNKPVILAWDSQFTHHLKQTLTFSARARDRELVIDKIKRGVPYSLAISVPVFFLLVTIGVSLALIVAFIRGTIGDFAIVIACIIGMSIPYLSYILFGQYFLAYKGNFGFPVFYQPYMSLAQSVILPIIIGVAARLGFQLRFYRTVMLDEMRADYVRTAFSKGLGTKTVLFKHVLKNALIPVITNVVLTIPYLILGSFLLERFFGIPGLGYLMLDAIGSRDFEVINALTFMVAILYVVFNVLTDVCYALVDPRVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNK3</accession>
    <name>A0A1U9NNK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_02660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69469">
        <property type="protein sequence ID" value="AQT69469"/>
        <property type="gene ID" value="STSP2_02660"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02660"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="36025" checksum="70E36C72E5AF0C12" modified="2017-06-07" version="1">MDTIVMLAGEFWGTLTEMAPYLLFGFLVAGILSVILSARFVENHLGGGGFWPVVKASLFGVPLPLCSCGVIPVGMSLRKHGAAKGATVSFLLSTPQTGVDSILATYALLGPIFAVFRPVIAFITGLIGGFAVQLTGGSGEKVAGEVADGAEEEDSCCGGKKQPFWLIRLFKHGFVTLPRDIGRPMIVGIIIAAILAAVIPDDFFASHVSAGLPSMLLMLVFGIPLYVCATASIPVAAVLVAKGLTPGAALVFLMTGPATNAATFTTLWNIMGRKTALIYLLTVVVCALSAGFLLDAMFPGIGGRVAEHMHEMDTAWWQHAAGILLLVVLVPGLFKKKHKEMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNM3</accession>
    <name>A0A1U9NNM3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">phoR_2</name>
        <name evidence="12" type="ORF">STSP2_02712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02712"/>
    <dbReference type="EnsemblBacteria" id="AQT69521">
        <property type="protein sequence ID" value="AQT69521"/>
        <property type="gene ID" value="STSP2_02712"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02712"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="373"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="592" mass="65579" checksum="C88DFE6E60F31288" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR3</accession>
    <name>A0A1U9NNR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type IV pilus biogenesis and competence protein PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pilQ_2</name>
        <name evidence="9" type="ORF">STSP2_02785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02785"/>
    <dbReference type="EnsemblBacteria" id="AQT69592">
        <property type="protein sequence ID" value="AQT69592"/>
        <property type="gene ID" value="STSP2_02785"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02785"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527459" evidence="7">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="502" mass="55399" checksum="D7EE61B07ED9D0E5" modified="2017-06-07" version="1" precursor="true">MKKQTIKSISIFAVICFAVLCLVSSRLTAAEHQAAEEEKSETRELSQIEKRMQQPVSLDFRETPIEDVLRMLAKQADVDIIKSPEVTGNVTATLTEVPLSEALDNILAAHGYGYVTTKNMIRVVPRSQIINVVEPMVSRIYRVTYADVVEVEKALSRFLSDSGSLSSNPGTSNIIINDTESKIAAIDEFIEEIDRVTPQILVEARIYDVSTNDSLDLGVEWFAGRRTQFDPDTGLAVSGDTDPFIRGEFDSGLQNTTATDGLLRFGILNEHVDIDATIFAEQEQGCAKLLANPRILVMDNELANIKIVSEVPFQQLTQTMGGGNIGTTEFKEVGVSLEVVPHLTRDGMIRLQLRPEFSVQVDTVSIIIPNQEATITSPQPVIDKREAVTTTLIKDGQTVVIGGLKKKDTFKDTSKIPLLGDIPLAGGLFRFDSEKIVNSELVVFITPYIVSEPVLTANEAARLKQTEFCSPDCRKSLQETCGQVTHLEGMEEPEKEHPYIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNT3</accession>
    <name>A0A1U9NNT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">STSP2_02577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02577"/>
    <dbReference type="EnsemblBacteria" id="AQT69388">
        <property type="protein sequence ID" value="AQT69388"/>
        <property type="gene ID" value="STSP2_02577"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02577"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="295" mass="33878" checksum="7738E52F886F7779" modified="2017-06-07" version="1">MASTRQILSRRRAAQNINKVTGTMETISAVRYRQLYGSWYEGQEFYDSLARLAYLIVTAEQTIEHPLLFDNQSRTHALVVIGSDRGLCGAYNSNIFKLLDVHRKMAKRFNRELKIYAKGNRVINHLRSQQVPIEHIYDEFEDVPSVDQTEEIANHFIEQYMRGEIGRLGMVYTRFFSAASQQAQTLSVLPVAELIDDLTTRATVIWPWEVEFEDFLLSPDPEQIFDGLAKMMIRTVISGCFHEAVLSEHLSRVIAMRSASDNAQEMIESLTHEYNRERQSQITNELLDILGGALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV9</accession>
    <name>A0A1U9NNV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase</fullName>
            <ecNumber evidence="3">1.1.1.335</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbpB</name>
        <name evidence="3" type="ORF">STSP2_02795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.335" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69601">
        <property type="protein sequence ID" value="AQT69601"/>
        <property type="gene ID" value="STSP2_02795"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02795"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="36981" checksum="A87CE08930BED228" modified="2017-06-07" version="1">MENTKPYRFALIGAGGYIAPRHLKAIKETGNVLEAALDKSDSVGILDSYFPEASFFTEFERFDRHIEKLRREDGHAVDYVSICSPNYLHDSHVRFALRIKAHAICEKPLVLNPWNVEALEAIEQEDTNNVYTILQLRLHPTILKLKREIESGPADRIHDIELTYITSRGKWYMHSWKGDITKSGGIATNIGVHFFDMLSWIFGAEKDNKVHYYTPRKAAGLLELEKARVRWFLSLDSEDLPFEPEPDKPKTYRSINIDGKEVEFSGGFTDLHTLSYKKILAGEGFGLKDSLPSLRIVSQIRNLNPIGLKGDYHPFLKKAFVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP07</accession>
    <name>A0A1U9NP07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase [NADPH] small chain</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltB_2</name>
        <name evidence="7" type="ORF">STSP2_02435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02435"/>
    <dbReference type="EnsemblBacteria" id="AQT69246">
        <property type="protein sequence ID" value="AQT69246"/>
        <property type="gene ID" value="STSP2_02435"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02435"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="145"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="474" mass="52333" checksum="769587CAC4F814D2" modified="2017-06-07" version="1">MADPKGFLKHKRQSVSYRPVEERVKDFNELEIPLTPDDLKNQASRCVDCGIPFCHGAGCPLGNRIPEFNELVYKGRWQLACEVLHSTNNFPEFTGRVCPALCEAACTLGINDEPVTVRHIELQIIEKGFENGWIEPVLPERKTGKKVAVIGSGPAGLTIAQQLARKGHDVVVFEKDEQAGGLLRYGIPNFKLDKGVIDRRLKQLEAEGVQFQTGVEVGKDISSRYLEKLFDAVCITMGAGEPRDLGVPGRGYDNIMFAMDYLGAQNQLLCGEIERSDLPNARNKKVVVIGGGDTGSDCVGTARRQGAKEIYQLEILPKPSADRPDETPWPFWPKIMRTSSSHEEGCERMWSTMTKSFEGYGTRVTQLKACKVEWIEHRGGWKVKEVPDSEFTISADLVLLAMGFVHVDHTGLVKDLDLELDSRGNIVTKEGQTSVPWVFSAGDSVSGASLVVNAIKDGREVAASIDEWLNSNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP35</accession>
    <name>A0A1U9NP35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-glucuronidase</fullName>
            <ecNumber evidence="7">3.2.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">uidA</name>
        <name evidence="7" type="ORF">STSP2_02465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69276">
        <property type="protein sequence ID" value="AQT69276"/>
        <property type="gene ID" value="STSP2_02465"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02465"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012617674" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="32"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="314"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120624" checksum="D7668160655F2AE1" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP94</accession>
    <name>A0A1U9NP94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02730"/>
    <dbReference type="EnsemblBacteria" id="AQT69538">
        <property type="protein sequence ID" value="AQT69538"/>
        <property type="gene ID" value="STSP2_02730"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02730"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="294" mass="32359" checksum="E43710C674BD4E8F" modified="2017-06-07" version="1">MNYTTPFKFAKIVITNFLEDEAIVRGAGLAFFTTLSLAPILTILLAIAGFISPQAQQELIESINDQVGPQVAKALEVVIKNASERQLAGKISVILSTGLLFFSATAVFVQLQKSINRIWGVRAQPQSRIWGWIRKRLMSLGMVLGIGTVILLSIVVSTVLTIILTGLTEIVDFAATLLVFVLLFALIFKFLPDVKISWKNVSVAAFSTAALFAIGRYALLYYFSHTTAGSAYGAAGSLFVLLLWVYYSSLIFFLGAEITHVYATGFGEEIEPADYAEYTKNHEDQKKRIRDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP97</accession>
    <name>A0A1U9NP97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exoribonuclease YhaM</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhaM</name>
        <name evidence="3" type="ORF">STSP2_02757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02757"/>
    <dbReference type="EnsemblBacteria" id="AQT69564">
        <property type="protein sequence ID" value="AQT69564"/>
        <property type="gene ID" value="STSP2_02757"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02757"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="37245" checksum="76AD1928FDD0F97B" modified="2017-06-07" version="1">MPHLFIKELKPGQMIEDVYMVTQPILRNTSRGDLYIAMYLSDKTGKVNCRMWQATQEIYESLPKEGFVRIRGKSELYQNAIQLIVNQVEVIDPDEVSLADYMPRTDKNVSEMFNEVNSILGEIKNSQIRALLSAFLSDKKLMKEFCTAPAATRMHHDYLGGLLEHTFTMLKVAKSILPLYPKVQADLVLAGIFLHDIAKTWELSYKMGFSYTDEGQLVGHIVHCVVMIDKKADELAANGTEIDRDIISNIQHMILAHHGQYDFGSPKLPATAEAFMLSRIDDLDAKMNQVVTEIENEPGDSDWTMWKNPLQTRLYRKKVTEADQLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPB0</accession>
    <name>A0A1U9NPB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69675">
        <property type="protein sequence ID" value="AQT69675"/>
        <property type="gene ID" value="STSP2_02870"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02870"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032583">
        <property type="entry name" value="DUF4914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16260">
        <property type="entry name" value="DUF4914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="630" mass="70376" checksum="1A48D7E8A13AA702" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE6</accession>
    <name>A0A1U9NPE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolG_8</name>
        <name evidence="3" type="ORF">STSP2_02988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69791">
        <property type="protein sequence ID" value="AQT69791"/>
        <property type="gene ID" value="STSP2_02988"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02988"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="215"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="461" mass="51971" checksum="A79F02C0AEB74087" modified="2017-06-07" version="1" precursor="true">MKRRDFLKSGLLATGTMVYAPNIVSSAVFAKTTPNDKINIGQIGFGRIARSHDLPETMKHDMCRVVAVADVDMDRALDGKKWIEDYYSKKTGKDNYVNVKAYQDYREMLADESIDAVIISTPDHWHAQPAMEAALAGKDIYLQKPAALTIKEGRQMSDVLNKTGRIFQMGSQQRSVNPWPQFKWVCELVRNGAIGNVKHVKVGLGTDPAGDFWPRMEIPKNLNYDMWLGSTPRIFYTEKRVHPQKGYGRPGWLRVRQFGAGMITGWGAHHIDTAHWGMGTEHTGPIEIEGTGEFPQKGLWNVHGDFDTYSKYANGVTMHVSSKHPNGVRFEGENGWIFVSRGNAKVTASDPVSGDPNNKAMQVSDPDILQHKIGPNDVHLYESPEQHLNWLNSIRSRKETVAPAEVGHRSCSACLLNHIAMQLPGKLQWDPHREQFIDNDEANHRLARDQRYPYGTNYVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF1</accession>
    <name>A0A1U9NPF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">STSP2_02872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02872"/>
    <dbReference type="EnsemblBacteria" id="AQT69677">
        <property type="protein sequence ID" value="AQT69677"/>
        <property type="gene ID" value="STSP2_02872"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02872"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12087" checksum="DFF3B7ED463E950D" modified="2017-06-07" version="1">MYAIIEQGGKQFKVAQGDVINIELTEADADAKSVEIDKVLFVSDGEQVKVGTPYLDGAKVVASFETTAKDAVVKGPKLYPTHLRRRKHSRTRIGHRQKYMQVTIDAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPH3</accession>
    <name>A0A1U9NPH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69644">
        <property type="protein sequence ID" value="AQT69644"/>
        <property type="gene ID" value="STSP2_02838"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02838"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18989" checksum="748812E3FA8DC271" modified="2017-06-07" version="1">MNEFYKKKDFYFILVPSLALIWVLTTIALKLPAAQNELDRTADQWQDAKPLVTEILTHDPGRLEYAAAQSQDGDFDFAKTIARLAPLNGISPSAYDLRSGPPITRGGNRTKTATLSIEDPVSIVTLTEFMSTLLSQWPDLQCDSAKIVKQSDGPDRWKADFRLTYNYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM8</accession>
    <name>A0A1U9NPM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-glucoside kinase</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK</name>
        <name evidence="1" type="ORF">STSP2_02992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02992"/>
    <dbReference type="EnsemblBacteria" id="AQT69795">
        <property type="protein sequence ID" value="AQT69795"/>
        <property type="gene ID" value="STSP2_02992"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02992"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39293" checksum="43E6FB09C7249498" modified="2017-06-07" version="1">MTKTDDQRIVLTLDAGGTNFVFSAMQANKEIATPVRLPANAHDLDKSLESMVAGFSQVIDQLDTRPAAISFAFPGPADYPRGIIVAPPNLKVYHGVALGPFLEDKFDMPVYINNDGDLFVYGEAIAGFLPKVNKMLEDAGSPKRFNKLFGITLGTGFGGGIVADGELYIGDNSTAGEIWITRSKRHPKCFAEEGVSIRAVKGTYARITGIDPADAPEPRDIYEIGTGKHDGNKDAALQAFAELGECVGDALANAISLLDCPIVIGGGLSAAYPLFIDSVLKEMNGTIDSLAGDKLPRMVQKSFDLEDPEDKKRFMQGDIKEVQVPGTQKTIKYDPMKRLGLGRAVLDTSQAISIGAYAFALSQLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR3</accession>
    <name>A0A1U9NPR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69899">
        <property type="protein sequence ID" value="AQT69899"/>
        <property type="gene ID" value="STSP2_03099"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03099"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="14169" checksum="BAB55C1040A316CE" modified="2017-06-07" version="1">MESVKTFPRGPKVKIGVDLDGTVSEYPEFFSFMTRALVSACARVHVITDRPIGTEWQVAKELEGYGVVWDEIVITGDKAGFIAREGVEVLFDDVDQYFEAVPQSVAVFKVRQHYNYDFEQGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS8</accession>
    <name>A0A1U9NPS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02914"/>
    <dbReference type="EnsemblBacteria" id="AQT69718">
        <property type="protein sequence ID" value="AQT69718"/>
        <property type="gene ID" value="STSP2_02914"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02914"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14596" checksum="26D269E577EED120" modified="2017-06-07" version="1">MEVPVELSRIVINETVDQQIIVLSEIGGDRGFPIVIGISEILAIDRRLKGIDLPRPMTHDLLANIIEQMGAKVDRVVINDLRNHTFYAVLHVVLDGREIEIDSRPSDALALGVGLNAPVFVEDQVFEKMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU9</accession>
    <name>A0A1U9NPU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative S-adenosylmethionine-dependent methyltransferase/MSMEI_2290</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02824"/>
    <dbReference type="EnsemblBacteria" id="AQT69630">
        <property type="protein sequence ID" value="AQT69630"/>
        <property type="gene ID" value="STSP2_02824"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02824"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="245" mass="27876" checksum="36D01B08E28C5E37" modified="2017-06-07" version="1">MSQKESKLEEDLQGQQRFYENTWEKGLAKGKKQRGDLQSNLSFLEKTGLLEKPCKILEIGCGIGSVVSRLSEQGHDAEGVDISETAIRYGREEYPGVKLNVQAAEKLPFADGSFDLVLSFDLFEHISEIDLHIEQVKRVLRNGGYYLFETPNKYSNALFETISSRSLRWKRFHPSLHSPGQLKKRLEKHGFGVSFVKISPVNDYNIIKVRRVFGGAAAKLFSSIGFRRLPLFMQTNLYVAARKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ10</accession>
    <name>A0A1U9NQ10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69877">
        <property type="protein sequence ID" value="AQT69877"/>
        <property type="gene ID" value="STSP2_03077"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03077"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15875" checksum="9849BF0A49408C48" modified="2017-06-07" version="1">MKQIARTLTDCEDGFLKDKTYLIHDRDPLYRTEGFHALLKTSGVEPVRLPAHSPDLNAYAERFVRSVKSECLDHLILSSVEQLEYVLGEYSNYYHHERIHQSLGRIIEPKHQLDETADIRCIERLGGLLKSYHRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ24</accession>
    <name>A0A1U9NQ24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfatase</fullName>
            <ecNumber evidence="3">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69818">
        <property type="protein sequence ID" value="AQT69818"/>
        <property type="gene ID" value="STSP2_03015"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03015"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="540" mass="61621" checksum="76CBB12665A8582E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ53</accession>
    <name>A0A1U9NQ53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplV</name>
        <name evidence="10" type="ORF">STSP2_03046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03046"/>
    <dbReference type="EnsemblBacteria" id="AQT69848">
        <property type="protein sequence ID" value="AQT69848"/>
        <property type="gene ID" value="STSP2_03046"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03046"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20086" checksum="29960DAC7E9EF2F1" modified="2017-06-07" version="1">MLSSSKLNSVCAERKMSLEQLAGHLAHGGMSTDDALRALKNWQKNLLKPAPKTEDVERLADGLGVAVGDISEWRASYRYAPSSPRKARLVTEMINGRSVQDALDVLKFEHKRAARMVEQVLSSAIANADEQEANVEELYVCEARVDGAGRRIGTKAWHPKDRGRAHPIRKQASHIHVAVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ61</accession>
    <name>A0A1U9NQ61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction-modification system methyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70072">
        <property type="protein sequence ID" value="AQT70072"/>
        <property type="gene ID" value="STSP2_03274"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03274"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="23377" checksum="070BDF9E1E56402B" modified="2017-06-07" version="1">MAIPYTIKNNNYNKNTKDSTIYTPERVSVYLFNLLQHHINPCVLLDPAIGKGSLTNIWRSRTCKIIGVDISRVGSDHCDTFIHGKFENIHAWSYESPDLILCNPPFNGAKGKKLYSEVFLRKMVDLFGPKVPIAMFAPMGMRLNVRAESKRWEWMRDTLDITSIVSLPIDCFGLKFHTEILIFNVPTLKPHYFLYEQSSCSTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP4</accession>
    <name>A0A1U9NQP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69940">
        <property type="protein sequence ID" value="AQT69940"/>
        <property type="gene ID" value="STSP2_03140"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03140"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8347" checksum="1087AAE43CB62DD1" modified="2017-06-07" version="1">MIYRFEKVDGGVCIDSPMSCPFRTMESAEGFCRLESRLVRGKEIKKLCPDHENFPPLCPLLMGVTLAAKARKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQS4</accession>
    <name>A0A1U9NQS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69970">
        <property type="protein sequence ID" value="AQT69970"/>
        <property type="gene ID" value="STSP2_03170"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03170"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13051" checksum="265766E5BA93BED1" modified="2017-06-07" version="1">MSTIGTITFLRMTGPQLPSLSTVVVPFQRPGVAGAGFRKEAAKADDYVLETVQAVGSQVSANQAANAYAAYKGQLVTVVDDTGKTTNAVMVLDARVTRVARVATSIPAGTEYLVYGRWSLKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQX2</accession>
    <name>A0A1U9NQX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">apbE_2</name>
        <name evidence="12" type="ORF">STSP2_03529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03529"/>
    <dbReference type="EnsemblBacteria" id="AQT70323">
        <property type="protein sequence ID" value="AQT70323"/>
        <property type="gene ID" value="STSP2_03529"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03529"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37254" checksum="410223108C76F0C9" modified="2017-06-07" version="1">MAESGKRFGWLSTLAGAVVVIAAAFGLRFLFAPGLVDRKSGYREVMGTFAQVVAVAEDGAVAKEAVEAGWDALVRVDELMSGYKEDSDVSRINREAGDGPVKVDEAVVEVIEEAVRYSEMTDGAFDVTVGPEIELWREAEKKGEVPNDEEIATVRERVGYEKLEVDEEANTVEFAVEGMRIDLGGIAKGYGIDAAVEAMKEAGAVGGMVDVGGDIRVFGVRGEKDEVGEWNIGLQNPVVEKGVLAVLKLQDAAIATSGDYRRYVEIGGKRYSHIFSPAEGGSATELTSVTVIAGEAVEADALATAVSVMGMEKGLQLVEGLAGVEAIVMRSGTEELVYTSGAEAYVERVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR90</accession>
    <name>A0A1U9NR90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-triphosphatase THEP1</fullName>
            <ecNumber evidence="4">3.6.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03503"/>
    <dbReference type="EnsemblBacteria" id="AQT70297">
        <property type="protein sequence ID" value="AQT70297"/>
        <property type="gene ID" value="STSP2_03503"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03503"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22319" checksum="A4B7E7F4F5F92383" modified="2017-06-07" version="1">MFFYFFAILNIAANETGSKIICMNDKPFKILIEGPPGCGKTTAIKEITSELPGCAFSGFYTNEMREEGRRVGFTITNFADHSEVFAHQDFDTPTKVGRYSVDVQTFEKIALPAIDIDHTTAPLLIIDEIGKMECLSEPFQQLILKAFDSQRDIIATVPNKGTGLIQQIKKHPSVKITRLSKSNFNETIYQILKTLQVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRG6</accession>
    <name>A0A1U9NRG6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ORF">STSP2_03416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03416"/>
    <dbReference type="EnsemblBacteria" id="AQT70210">
        <property type="protein sequence ID" value="AQT70210"/>
        <property type="gene ID" value="STSP2_03416"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03416"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="149"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="313" mass="35191" checksum="92964081A3E6EF56" modified="2017-06-07" version="1">MKDFIAIGDCTADELRELLHLSVQGKQIDKLGGRDKSLPGKTLAMIFEKASLRTRMSFQIAMTDLGGHAVYLKPEDVGIIGDREPAKDMARVLARYVHGIMARTYKHETLIELAKYADVPVINALSDWSHPCQAMADILTMYEHCGDLEGRKIAYIGDGNNVARSLAFACAKFKIKIAIASPRGYELDQRSLDMCNDLMPETAVQLNDGFEAAKDADIIYTDTWVSMGQENEKAERVDDFKKGNFQVNSELLSYAPPRAKVMHCLPAYRGMEITDEVAESDRSVIFDQAENRLHFQRALLKKLLFQNPKAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRJ0</accession>
    <name>A0A1U9NRJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70334">
        <property type="protein sequence ID" value="AQT70334"/>
        <property type="gene ID" value="STSP2_03540"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03540"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="349" mass="40038" checksum="BB0576CB8C9FB15B" modified="2017-06-07" version="1">MEYKNYVVCKGILGIQTNSDYIGWSFGHPTESSSDEAISDCEIVVRLTISDLKAESNRMSSLQKYHYWRGEVGSDELFYERNFLAGSKLRMHVSGIKSGKPEIKVNKPFIKYIKFRFNNLHSPGYILTDLVSVLLLQKGFCPLHCSGFAINNSSVAVVAPGDTGKTLTTMKAVFDSKADYMAEDLGIVDDQTFYGCPWTSTFRYYDELSMSRLLRFRMKMVKIFPPVELLPVPGDHRNIDHYISTERIRHDNKLTHLALLARRPGGIKVLDNEEAENMLFNLNRYEFCYMKSPMLIAYSYFNDNIDLMECEKKEREVLSKLVENAECLLVQSEDPTKFAELIFDRVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRK3</accession>
    <name>A0A1U9NRK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ORF">STSP2_03560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03560"/>
    <dbReference type="EnsemblBacteria" id="AQT70354">
        <property type="protein sequence ID" value="AQT70354"/>
        <property type="gene ID" value="STSP2_03560"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03560"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="203"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34471" checksum="21AD4392580438A9" modified="2017-06-07" version="1">MKITYFGSAEFGIPCLDAIKNSKHELAGIFTQPAHGAGRGRKPRPTHVAQWAERNGYECVEAENINRPEMVERVRACGGDLLVVIAFGQKIGPEVIEMHEKGAINVHASLLPKYRGAAPINWAIVNGETETGVSIITLADKMDAGYVLGEGKVAIDADDTAEDVHDKLAELSPGVLMDVIGQIEAGTAKYVEQDEDRVTIARKLKKSDGQVDFDRPAEQVRNMVRGFWPWPGAKADYVSAKTGKKDRVTLAQVRVVEDAGSDGEPGVIDDEFHVQCGAGKLDIVKLKPAGKRLMNWEAFCNGRHTQPGDKFVKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRR2</accession>
    <name>A0A1U9NRR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70300">
        <property type="protein sequence ID" value="AQT70300"/>
        <property type="gene ID" value="STSP2_03506"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03506"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="398" mass="44992" checksum="B5269A73CCE1F4EF" modified="2017-06-07" version="1">MAFMTAKRKKIKEHQLAGFKYFKSISGMLESLHEAGCENDRAGNRLLHMDQYMSLLLLYMFNPICTSLRAVQQASELKKVQRKLGCPRTSLGSLSEAARVFDSQLMQEIVDDLAAKLGPVSLNSKLNDLSGILTAVDGTVIPALSKMTWAFWKTDKNAVKAHAQFDLEKHVPLKLTITEGKEDERRTLAGNLEKGRIYVQDRGYASYALFQQIIDAGSSFVCRLHDDAAYETLEEHSLSEDARNASVLFDRTVRLGSNLRMKQKLSSPVRLVAIKCTPHIKRAKTGRGGPEQGQTLLVATDRLDLDADVIALIFKQRWTIEIFFRFFKHVLGCRHLLSYCHNGIELQTYAAIIACMLISLWTGKKPTIRTYEMLCWYFTGMADEEELLAHIGRLRPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NS14</accession>
    <name>A0A1U9NS14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase DDE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_03512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70306">
        <property type="protein sequence ID" value="AQT70306"/>
        <property type="gene ID" value="STSP2_03512"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03512"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="142"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="322" mass="37317" checksum="9DAC8ACB8796A32C" modified="2017-06-07" version="1">MERSRNQPTFLDNVISELGGRRTAKFFAKCDKYIPWDELAKPLKDMYSNNTSKGGASNWPVIMMVKCIMLQKWFNLSDPMLEEMLLDRLSFRRFVGLSMDDNTPDETTFVRFRKRLREHRHDRTLFEKTLEILSTRGVILAEGTCVDATIVEAPRGRKRADGSNTRDAEAGFTKKNGRSYHGYKAHIATDTNGMVKDYRFSSARHHDSKFIDELIENETQSVWADSAYMSAEREERLGEKGVLAGIVHRRKRGQAELNELRQIINRIISRVRAVVEHPFAWMKNAGYGKVRYRGLERNRLDFAMHAVAYNFKRSFSLHKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGA1</accession>
    <name>A0A1U9NGA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66953">
        <property type="protein sequence ID" value="AQT66953"/>
        <property type="gene ID" value="STSP2_00091"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00091"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9576" checksum="7816B244F851AB63" modified="2017-06-07" version="1">MGTTGWVVLGVVNIPIYVGLGWVFFRDWDGFWEAIRFWLTPDVFSMFTGEFFDDWWAESKLAAWVILCGACVIGEGLLINTMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGC2</accession>
    <name>A0A1U9NGC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66979">
        <property type="protein sequence ID" value="AQT66979"/>
        <property type="gene ID" value="STSP2_00117"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00117"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911327" evidence="1">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22985" checksum="E3BDE9724F3F18AE" modified="2017-06-07" version="1" precursor="true">MRTGLIILMLVMLAGASAWATNIDPYDEEEQYVWSENVGWIDAKANGDGMEVTSGKVMGYLWSSSVGWINLYPRSSDPAVGVKNDGQGNLSGLAWGENVGWINFDPKVPNSKVDYGVKIDADGYFSGWAWGENIGWINFNSASLAPYGARVCIVKLEDLERFASQWLRSGYIYAADLNRDYQVDFADFALFAKLWLDYCPCDWGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGH2</accession>
    <name>A0A1U9NGH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67041">
        <property type="protein sequence ID" value="AQT67041"/>
        <property type="gene ID" value="STSP2_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00180"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012730654" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17938" checksum="542FA68ACE4DDA09" modified="2017-06-07" version="1">MGRCYLVMFMALGMLALAGCEKDSGNSGQVELSGNDVARALGMNAWEVTLPADHDKDATVGLKLKYPDGSVKRLSGVGSVSPGTVCKIVVWRSDDKLKCALLTDRHSTRSDGMEMQEIVGDFRGAMLFEAERKLGDMLMKWGNDKVLSSSTVNEGEVALIFDVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK0</accession>
    <name>A0A1U9NGK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheR</name>
        <name evidence="7" type="ORF">STSP2_00016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00016"/>
    <dbReference type="EnsemblBacteria" id="AQT66878">
        <property type="protein sequence ID" value="AQT66878"/>
        <property type="gene ID" value="STSP2_00016"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00016"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="32781" checksum="4D71E521D0FCC697" modified="2017-06-07" version="1">MVGCTTYSSDANLTDDDFRQVSRVIYEHCGINLHDGKKELVRARLAKRMRVTKRRSISDYLSYALRDHSGKEFSLLVDAISTNLTSFFREQKHFDFLCDEFLPSLITKKRASGDKVVRAWSAGCSSGEEPYSLAITLLSELKNAPEFQVKILATDISTTVLDRARTGIYPEKRVAPVPAELKHRYLIREKSDGEKMFRVAKILRECIYFGQLNLMQEWPIKVPLDFIFCRNVMIYFDKPTQERLVNRYYDILQPGGVLFTGHSESLTGIKHRFRYVQPTIYAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR9</accession>
    <name>A0A1U9NGR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66934">
        <property type="protein sequence ID" value="AQT66934"/>
        <property type="gene ID" value="STSP2_00072"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00072"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8034" checksum="B42AE162BA046EFB" modified="2017-06-07" version="1">MKQYIRSLAVTVAVLAFFLIAGIGACSDVDPLVCGYRGICGAIFVYVGATIALRLAMRIVVAQIISNQGNQNRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGU9</accession>
    <name>A0A1U9NGU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid partitioning protein RepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00102"/>
    <dbReference type="EnsemblBacteria" id="AQT66964">
        <property type="protein sequence ID" value="AQT66964"/>
        <property type="gene ID" value="STSP2_00102"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00102"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23653" checksum="863E6C6395FA4EB6" modified="2017-06-07" version="1">MAQNKICRLPLSRLVEHEANPNRMNKSTFEKLVRNIDRTGNYEPIVVRKHPSRAGDYQVINGHHRRKALMELDRTHADCVVWDVDDDETMVLLATLNRLGGQDDLQKKRELIEQLAKKYSSDDLAKITNETQASIQTLKDLRESCIEAKPAKPEMLVPEVFYLREEQQEAVRDSIAKACPEAGTKAQKRAAALVKICRAYEEAGEQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH16</accession>
    <name>A0A1U9NH16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipopolysaccharide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00187"/>
    <dbReference type="EnsemblBacteria" id="AQT67048">
        <property type="protein sequence ID" value="AQT67048"/>
        <property type="gene ID" value="STSP2_00187"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00187"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="530" mass="58995" checksum="E7B36D60C5832188" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH50</accession>
    <name>A0A1U9NH50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67262">
        <property type="protein sequence ID" value="AQT67262"/>
        <property type="gene ID" value="STSP2_00405"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00405"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="115"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="261" mass="29365" checksum="F0A6FF7D5F246B74" modified="2017-06-07" version="1">MNSSEILTSDELMDVLAQAAEDQREATMSYLSGGKWHVLEVRLCFCSSEVLHVEAAERSNSVAYIQIDQPVGISFEKDFCKYVFETSVAGYQTGINSGLAGRAILLRPDRVEKLQRRAYYRAQVPADMRVKALFWHRGYTNNDVEIPAENYWEGHMLDLSAGGTLIEVDERLRDNFKEGQLVGVQFTPKPYAKPFLLEGLLRHIGEEWNGQVRLGVEFLGLEASAEGRETLRRLVEVVEEYREAENAQECGPVVAGDETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH65</accession>
    <name>A0A1U9NH65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">STSP2_00224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00224"/>
    <dbReference type="EnsemblBacteria" id="AQT67084">
        <property type="protein sequence ID" value="AQT67084"/>
        <property type="gene ID" value="STSP2_00224"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00224"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19739" checksum="6C7AA99B007BA3BF" modified="2017-06-07" version="1">MHHDPVTAIFPGSFDPITKGHIDVIERGVKLFDRVIIAIGQNPTKDQLFTPAERVEMIRELVTDMPRVTVQSYACLTVEFAKQVHADVMLRGLRNLTDVQYEFQLAMTNRAVAGVETVFIMTSEEYGFVSSTMVREVALLGGDVSNLIPAPVYKRLQERVAHRKPNPETDPTNKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH90</accession>
    <name>A0A1U9NH90_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein YlmA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ylmA_1</name>
        <name evidence="5" type="ORF">STSP2_00444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00444"/>
    <dbReference type="EnsemblBacteria" id="AQT67301">
        <property type="protein sequence ID" value="AQT67301"/>
        <property type="gene ID" value="STSP2_00444"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00444"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AQT67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29187" checksum="C52C92F79903028C" modified="2017-06-07" version="1">MALPIIDIDSVTFRRKDSVILSDVSWRIEPGRNWALLGGNGAGKTTLLNIVLGYAWPTTGSVTVFGEKFGDCAIRELRKSVGYVSSSMGDRVPTLDTPLEIAMSGIDASFGLYRQFTEAETVRGRRTLEAVNVAHLAERKFATLSQGERQRVLISRALVNEPKLLVLDEPCVGLDPAARHDFLCDLGEMAGRDDAPAIIFVTHHIEEIHPWLDSVFMLKDGSCLASGSSEKHINSDTLGELFNCDCEVTRTGHGWSLNINGKTNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHA3</accession>
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        <submittedName>
            <fullName evidence="2">Zn-ribbon-containing, putative RNA-binding protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">STSP2_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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    </dbReference>
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        <property type="gene ID" value="STSP2_00455"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
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        <property type="entry name" value="DciA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="128" mass="15000" checksum="E7CDE56EEE17B6A3" modified="2017-06-07" version="1">MAPASRSDEDKLLRSVSRWKKKKKDRTSPLSQVVRSYMDRNQPVFEKNAEVVEAWRDILPEHFYDHCQLAAIDKGVIRIEVDSGPFMHEMRLLSGELLEHLKSRCPRAKLKKIVLCPRKARQDTEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHB6</accession>
    <name>A0A1U9NHB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67195">
        <property type="protein sequence ID" value="AQT67195"/>
        <property type="gene ID" value="STSP2_00338"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00338"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9993" checksum="D0D31EF6377DC6F6" modified="2017-06-07" version="1">MVVVRLALRGDSRLSRRSRLVWLHADVFVVDGRAFIVYFTHPGRVYDDKGVEKHEDTLEYRRSSLQAAELKLVDGKIVCDRDEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD5</accession>
    <name>A0A1U9NHD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,5-diketo-D-gluconate reductase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00158"/>
    <dbReference type="EnsemblBacteria" id="AQT67020">
        <property type="protein sequence ID" value="AQT67020"/>
        <property type="gene ID" value="STSP2_00158"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00158"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="420" mass="47436" checksum="450DD1FBD87A8FD6" modified="2017-06-07" version="1">MKTEGEGLNRRNFLRNAGAASVVSALGAGKVLADEHKKEAKTEQAAEKEQAKEKEDKHPKVPKRKFSKKIKEEVPILSMGGMFPIPDNQIVLHTAYKWGVTYWDTANSYEGGNSELGIGKWLKRFPDRRKNLFIVTKASGARNNEQRDKKLQLSLDRMNTKYVDLYYGVHGLRNPETQLTDELKTWAEKAKKAKLIRYFGFSTHSNVTECLEAASKVDWVDAIMLKYNFKMMDDERTQKAIQACYDKGIALIAMKTQAKGMGNEDEKKLIDYFIERGFTSHQAKLKAIWKDKRFCNICSQMPNVKILTENIASAFDKTELKDVDMAVLSDHAKECGGFCAGCANICENAVAGSPDISDTMRYLMYYNSYGEPERAKAEFAAMPADRKRILANADFTEAERKCPQNLPIASLVKEAFEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG4</accession>
    <name>A0A1U9NHG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)-translocating NADH-quinone reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_00505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00505"/>
    <dbReference type="EnsemblBacteria" id="AQT67361">
        <property type="protein sequence ID" value="AQT67361"/>
        <property type="gene ID" value="STSP2_00505"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00505"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FMN_bind" evidence="6">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22238" checksum="D16771B26400A8DC" modified="2017-06-07" version="1">MRNIKFFFRQSWLVIVASFAFGGLLALTNAALQPRIQANLIAKFNRTAGNLLPDAKNFEVPQAFEDLEKIKTDSGDELSIQIKKAIDAEGNLVGWAFTAKGPGFADMIELVIATGPKLESIKGFGVLKSNETPGFGDQINNDFYQDQFHGAPTASLELSKIGDASKIDNTIVAITGATVTSDAVVNIFNTYLPEVKELLAENQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHK8</accession>
    <name>A0A1U9NHK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00543"/>
    <dbReference type="EnsemblBacteria" id="AQT67399">
        <property type="protein sequence ID" value="AQT67399"/>
        <property type="gene ID" value="STSP2_00543"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00543"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13783" checksum="6AC73078DE9AB2A3" modified="2017-06-07" version="1">MWEVEFTDEFEKWWQTLDVKQQEDVLVSVELLRNLGPHLARPYADTVKGSKHKNMKELRTQSKGRPLRTFYAFDPRRYAVLLLGGDKKGNSRFYQQLINKADQIYDRHLNDIKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM0</accession>
    <name>A0A1U9NHM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA</name>
        <name evidence="11" type="ORF">STSP2_00448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00448"/>
    <dbReference type="EnsemblBacteria" id="AQT67305">
        <property type="protein sequence ID" value="AQT67305"/>
        <property type="gene ID" value="STSP2_00448"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00448"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="409"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT67305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="584" mass="62374" checksum="4EC96470037F84B2" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHM6</accession>
    <name>A0A1U9NHM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">STSP2_00420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00420"/>
    <dbReference type="EnsemblBacteria" id="AQT67277">
        <property type="protein sequence ID" value="AQT67277"/>
        <property type="gene ID" value="STSP2_00420"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00420"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33811" checksum="30428DB68B695F72" modified="2017-06-07" version="1">MGMFGKTVGFIKDRLTKTREKISSSLMSVIGLGRKIDEDLLDELEEVLISDDIGVETTDRLIEDLRDAYRKKQIVQTDDIIPFLKEKMKDYWPEQHRQLNASQSGPTVILVAGTNGSGKTTSIAKLAYTLSRNNKKVVVAACDTFRAAAVEQLTIWSERIGVQIIKHKMGADPAAVAYDAVEAAVARDVDYLIMDTAGRLHTQKHLMAELGKIRKVVRKRLPDAPHEVLLVVDATTGQNAIMQAKTFTETINVTGIFLAKLDGTAKGGIVIAIKDQLDIPVKFVGLGETPEDIAEFDPDEFVEALFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHP6</accession>
    <name>A0A1U9NHP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="2">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuA_2</name>
        <name evidence="2" type="ORF">STSP2_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.3.13" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00175"/>
    <dbReference type="EnsemblBacteria" id="AQT67036">
        <property type="protein sequence ID" value="AQT67036"/>
        <property type="gene ID" value="STSP2_00175"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00175"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="442" mass="50062" checksum="032C8CFDCE4E5753" modified="2017-06-07" version="1">MIDKKIQLNDISRPNLYRDVFPYTEFPKVSFESEPVQIDIPDDIWITDTTFRDGQQSRPPYTPEQILRIYDFLHEIDAGTGLIRQCEFFLYSNRDRKAVELCQARGYEFPQITGWIRATKHDFKYVTDAGLSETGILTSASDYHVFLKLRKVRSQAIQGYLDVVRSALDQGVVPRCHFEDITRADYEGFVLPFADELLDLAKEYDSPVKIRLCDTLGFGVPYPNASLPRSIPRLVQGLRQLGFPAEWLEWHGHNDFHKVQVNAATAWLYGCASANCSIFGVGERTGNPPLEAMIVEHAQIAGTNPKINYAAITELARYAQTELGFEISPNYPLVGKDFNVTRAGIHADGLLKNEEIYNCFDTSKLLDRPIGVAITDKTGAAGIKHYIESRYDISIAKHDPRVIEIKDRIDAEYEANRVSAISEDEMDEWIVQVFDGTLPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHS8</accession>
    <name>A0A1U9NHS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67066">
        <property type="protein sequence ID" value="AQT67066"/>
        <property type="gene ID" value="STSP2_00206"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00206"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013273547" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20575" checksum="5DF057B621307F77" modified="2017-06-07" version="1" precursor="true">MLRLSIIVLFCTVISGCASHSMNVILPEGAVFPEQMVGTWSNIDTGWEITFENDGEIPSAVLALGRFEIEPGQTKTYEMKKGKSSRLEAGEWTVQYDSDSEEVTVEIVIEDLHVEIGGGYLEGHLTEILAGVVSEDGQRWNVDWITMPQYVAYTTGNEEGMPLQEPGETQVKQLVFKKAADDGEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHX0</accession>
    <name>A0A1U9NHX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67106">
        <property type="protein sequence ID" value="AQT67106"/>
        <property type="gene ID" value="STSP2_00247"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00247"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="9556" checksum="E3272C565F04956C" modified="2017-06-07" version="1">MSSERWTMNRQVNLSFLLQLLCLASLIIGSWTNIQNQLEVLQRDVSRLLQKSEQFHERVQHLNEQSIALDYRLRSVEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI38</accession>
    <name>A0A1U9NI38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atsA_9</name>
        <name evidence="7" type="ORF">STSP2_00737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67589">
        <property type="protein sequence ID" value="AQT67589"/>
        <property type="gene ID" value="STSP2_00737"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00737"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032158">
        <property type="entry name" value="DUF4994"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16385">
        <property type="entry name" value="DUF4994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4994" evidence="6">
        <location>
            <begin position="399"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="513" mass="57206" checksum="9C4E6E48CD67A982" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI56</accession>
    <name>A0A1U9NI56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster repair di-iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00757"/>
    <dbReference type="EnsemblBacteria" id="AQT67609">
        <property type="protein sequence ID" value="AQT67609"/>
        <property type="gene ID" value="STSP2_00757"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00757"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364414" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25808" checksum="F8F830CFC0E33E75" modified="2017-06-07" version="1" precursor="true">MKKHIATLIISSVVATAIAGCTCPARQAQAHSATPAAESTQNKQSSDIQMNREAPVKVLSKEHRATEIVLNAAEQEAKNIRTTGKIDTAKVDKIIKFARNFTDRCHHAKEERYLFPALHKAGQHADTIAVVKAEHELGRDLVNMIETLNRKQAAVPGDQTGQLAQHLQDFADLMYKHIEKEDNILWPAAHNSLTAEQLDKVGMGFYTVEFVELGEGFHHKYHQLAMELKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG1</accession>
    <name>A0A1U9NIG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67370">
        <property type="protein sequence ID" value="AQT67370"/>
        <property type="gene ID" value="STSP2_00514"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00514"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="419" mass="47699" checksum="011C085EB9C8AB11" modified="2017-06-07" version="1">MRLERIFVCGVFILCCLVGGICFGGEDVEAGSAAERFEEALGEVDPDAGDDEMVEQMKEAMGVESDEEMFGVMLEAMRESADRIEDGAEKLARRRERLIDTYRGELAELEKILRAEEDECEKALRLVDKKRAELKETADRRGKESKSKRELARQIYALGLEVLADRIEFMLGVRQVCEDECGDAVTEWVEDRLVGLRFVYIERLGMNVTDILKADRESGDVLRESAFLPSYMTHWREVDFGEAMPELYESRRRMPKGGPGMIGLMPGGMFGGKRPIRPSVYGWAGGGANMHYCVEKGKVGQFVRDVREFCEEAGYEALEFDLCVPEMEGSADAAWIGGPGEAEAWNQFWYDDAGRVFGVSVMRSEEKGNEVRWVYLPREKVEAVMDYLRLEDGEYEVDEERMEAGDFYRLRDVTDSEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG2</accession>
    <name>A0A1U9NIG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67719">
        <property type="protein sequence ID" value="AQT67719"/>
        <property type="gene ID" value="STSP2_00867"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00867"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28304" checksum="3432A6D2DF61BCCE" modified="2017-06-07" version="1">MLADSGGETTSLSNGDIISRILIYYSGFLRREKMMRTNRIILCLMVLALFSAGAMGAFIVETHSSGRGNANFNAVNGDPHYSSPTSGAPGLTATHHAWGSYGAFPDIYEFSYTPGTDADNWAVPDYQYFGNGDYTTGKPGGQTGYYNVYITFPSSINVSSLCDITVTSDGDPVVLTGVNMNTGGTTTEGQPWLGANDSWWMIAERVLLTEGQTYTVTQAAQDDSYVSMRSAGVMWEFVETPEPTTIALLGLGSLALRRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIG5</accession>
    <name>A0A1U9NIG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">STSP2_00686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00686"/>
    <dbReference type="EnsemblBacteria" id="AQT67538">
        <property type="protein sequence ID" value="AQT67538"/>
        <property type="gene ID" value="STSP2_00686"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00686"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="39"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="281"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="426" mass="46560" checksum="5F884D8F845E6DAA" modified="2017-06-07" version="1">MDHFRYKDGRLYAEGVDVSKIAEAVGTPAYIYSKATFLDHLKKVQEAYSELDTTICYSIKACSNINILKFLAQAGSGFDIVSGGELFRAQQAGADTTKIVYAGVGKTDQEIVDAMNAPIGYFNIESEMELENLIKLAREHDKNPKAALRVNPDVDPKTHTYTTTGKKESKFGVDIERARRVFEEYGKNGQVDLCAIHVHLGSAGKTVEPYVEALEKTLKLIDDLRADGHTIEAIDLGGGYGADYETNTAPAAANYAAAIVPMLKGKNLKLILEPGASVAANSAIMLTKVLYLKKGGKKKFVIVDAGMNDLIRPPLYGSFHFIWPAVVEDKFMPGKRQKDMNIDGSEIVDIVGPICEGSDFLAQGRSLAPVQRGDLISVFTAGAYGYTMSSNYNSRPMLPEVLVDGDTFTTIRKRQTYSDLIALEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH3</accession>
    <name>A0A1U9NIH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67587">
        <property type="protein sequence ID" value="AQT67587"/>
        <property type="gene ID" value="STSP2_00735"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00735"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29814" checksum="8307CF734C147E7E" modified="2017-06-07" version="1">MKKSAFTLIELLVVIAIIALLLAIMMPALGIVKQKAQGVVCLARLKNLSIGYQTYAVENGGKLPNANTPRPNDPYYNTAWVVAPQTEDEVDKSGGSTVEEKINGIERGVLWDFIKDADAYHCVGDQRYKKPSEHGSYGGMGGFRSYSIPGGLNGGDANWVYKRLSQIKKPSSIYAFVEEAEPRGYNLNWWALPRTGDKWTDPIAIWHNEKSALGFVDGHAEMHNWKDKTTLEMGWNQTIHKYVDPEKDGEIEDLRYMQEHYPYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIH5</accession>
    <name>A0A1U9NIH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
            <ecNumber evidence="5">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yitJ_1</name>
        <name evidence="13" type="ORF">STSP2_00682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00682"/>
    <dbReference type="EnsemblBacteria" id="AQT67534">
        <property type="protein sequence ID" value="AQT67534"/>
        <property type="gene ID" value="STSP2_00682"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00682"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="12">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="622" mass="66818" checksum="489E2B6A8D5E513E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIJ3</accession>
    <name>A0A1U9NIJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acyP</name>
        <name evidence="7" type="ORF">STSP2_00554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00554"/>
    <dbReference type="EnsemblBacteria" id="AQT67410">
        <property type="protein sequence ID" value="AQT67410"/>
        <property type="gene ID" value="STSP2_00554"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00554"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10353" checksum="3845F9E6BBF2E953" modified="2017-06-07" version="1">MADTAKKIIYKGRVQGVGFRYTASRIADRYELKGYVKNLPDGSVEIFAQGHPDDIQDFIADLQETFAAHIRDREMHKQEPSGRYQGFGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR0</accession>
    <name>A0A1U9NIR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugpQ</name>
        <name evidence="2" type="ORF">STSP2_00627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00627"/>
    <dbReference type="EnsemblBacteria" id="AQT67480">
        <property type="protein sequence ID" value="AQT67480"/>
        <property type="gene ID" value="STSP2_00627"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00627"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24161" checksum="4ADCB4D312DACBA7" modified="2017-06-07" version="1">MASVRSAWDAGADGVEVDVHMTRDGEVVVIHDADTGRTGDRRLVVKDSTYDELRAVDVGGGEAGDFAGERIPRLGEVIETLPAGKRLFVEVKCGGEIVQGLRRVIEGSGKEGQIAVICLAADVLELAAGAMPGVKMYWVLGSREDDDGEYAVYDDALIGGAAERGFDGLDVYHEALTAEYVEKAKRAGLEIYVWGVNELAAAERMLRIGVDGVTTDYPADVMRMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIU5</accession>
    <name>A0A1U9NIU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00992</name>
        <name evidence="2" type="ORF">STSP2_01947</name>
        <name evidence="3" type="ORF">STSP2_01981</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67841">
        <property type="protein sequence ID" value="AQT67841"/>
        <property type="gene ID" value="STSP2_00992"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68775">
        <property type="protein sequence ID" value="AQT68775"/>
        <property type="gene ID" value="STSP2_01947"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68806">
        <property type="protein sequence ID" value="AQT68806"/>
        <property type="gene ID" value="STSP2_01981"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00992"/>
    <dbReference type="KEGG" id="alus:STSP2_01947"/>
    <dbReference type="KEGG" id="alus:STSP2_01981"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12382" checksum="D99850813E73603E" modified="2017-06-07" version="1">MREPYNEGLASHIGPESCGWVGNDTSEALTGVHAGRVLSRVSSCVTDRSADAVETVGRQYWIRRYRKAYSDSARSKTPCTHGNSLHRNWEILCSALSKESGKVRTANPEGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIV8</accession>
    <name>A0A1U9NIV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67755">
        <property type="protein sequence ID" value="AQT67755"/>
        <property type="gene ID" value="STSP2_00904"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00904"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="90" mass="10686" checksum="6E413959BB7737E4" modified="2017-06-07" version="1">MAKERSQYQKNVISRYYENLDNIMLSKLQELVTELYLADSKAKQDRLWERVEKAMVKLKIKPAMIEHIMSQRSVTVLAKNLEDWLKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIW0</accession>
    <name>A0A1U9NIW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase RsbU</fullName>
            <ecNumber evidence="2">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbU_2</name>
        <name evidence="2" type="ORF">STSP2_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00678"/>
    <dbReference type="EnsemblBacteria" id="AQT67530">
        <property type="protein sequence ID" value="AQT67530"/>
        <property type="gene ID" value="STSP2_00678"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00678"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43933" checksum="F984398D8C8F9F78" modified="2017-06-07" version="1">MSETDLLKALGIQTATSDVVFCGVADPGKELGELLDSGGLSWGCASVDKIVDYLEGDSRPGTIVLDTRGMNVAQREKVGLVIKSLESRGVATIFVNDAIGFSLDEFELATKVRDFDAAELIGRIESNVAYAKAMKGMLARNRKAVVDETAEDRAQQLRMAGQVQRDFLPSRLPHAEHIRWATLFEPADCVSGDIYDVQRLDEQHIGFYLADAVGHSMPAALLTMFLKQAIVMRETKGNDYRIFGPLEVMQHLNKRMTEQQLSGCLFATCCYGLLNMRTLQMSYCRAGHPYPILKRPGCEPVMFEGKGGLLGVFEGGEFSQELVQLAKGDKLFMYSDGAEPLIGEVDEKGQMEMSSEFKDILKLGVEDLVGEFDKLRMRELKSGYEKDDVTVVALEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ59</accession>
    <name>A0A1U9NJ59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67620">
        <property type="protein sequence ID" value="AQT67620"/>
        <property type="gene ID" value="STSP2_00768"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00768"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17058" checksum="ECDE25D8212BD24F" modified="2017-06-07" version="1">MAIQAPYSSYRKKNLVIWAVVLLAAAAWFAYDGYINEDFIQEHTSEEGVADSDLKLNRMAPFVLVPGAALLGIGYWLFGKKKVTADEEGITAEGRSIKYDQIEAVNKTHFDNKGKFTVIYKDANGKQDELVLSRYKYDNISAVLDKIVEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ84</accession>
    <name>A0A1U9NJ84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67885">
        <property type="protein sequence ID" value="AQT67885"/>
        <property type="gene ID" value="STSP2_01037"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01037"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="510" mass="56582" checksum="01FCA7B943A69B88" modified="2017-06-07" version="1">MSERNRQRCELRSLIQVMLDGSISDADFDKLRELVNSNAELRYYYVDYMSLCAALKRYGSANKTHQPELSEPEMTDLWQQLVLMEKTARTVEIEPPPVKAAPVREPIPSRCSDRHTKTSRMLAMTAILSATAFLFMFVYLFFIPEGGPVVATVGNSYEAQWSGSGEDMKVGKKLQTGIYKLLSGFAEIDLESGTSVLIHGPAEVEFEGKNTVFLWQGSVSCKVPKEAVGFIVRTPRATVVDYGTEFGVKVGKAGQTQAHVFEGQVELRKGIDPVVFDGFLRLNKNESGVVNANDSLARQNYSDSLFVRDLDSLLSSHELMDKNLIVNGDFESGPVGEPFDNGDITNIVIEGWMDEAPATIFSYSSESQPFPQKGRDPLPPDCGDNFFVGRDDCLISQEIDLKPLTYLIDRSEITYQLSAWLGGFKDHGDSATIEVDFLDSSGKLVGSEKLEPSTPEERNNETRFINRSKVGRIPIGTRKATVTVSVVRTYGVADAYVDNIELIVREAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ91</accession>
    <name>A0A1U9NJ91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67808">
        <property type="protein sequence ID" value="AQT67808"/>
        <property type="gene ID" value="STSP2_00958"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00958"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045926">
        <property type="entry name" value="DUF6345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19872">
        <property type="entry name" value="DUF6345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013160470" evidence="1">
        <location>
            <begin position="22"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="659" mass="71378" checksum="508CC1833C8344B9" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJB8</accession>
    <name>A0A1U9NJB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68022">
        <property type="protein sequence ID" value="AQT68022"/>
        <property type="gene ID" value="STSP2_01176"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01176"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="164" mass="19065" checksum="65C4DABCCD0761FD" modified="2017-06-07" version="1">MCLYARDLSTSEGQQIQRILRSSKSRIKIRRGQVILASNQGYKVPAIAELVHYSPHHVRVIIKDFNQRGLKALEPKPRPGRPPEFTEDDKAIIAETAKCPPDLLDCPFKRWSLEKLREYLVQEKIVPTISIETLRTILHEKKVKLRRTKTWKECNDPDLKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN3</accession>
    <name>A0A1U9NJN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">iolG_4</name>
        <name evidence="8" type="ORF">STSP2_01298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68143">
        <property type="protein sequence ID" value="AQT68143"/>
        <property type="gene ID" value="STSP2_01298"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01298"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="6">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="7">
        <location>
            <begin position="368"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="448" mass="50504" checksum="C11D996C9D7928CF" modified="2017-06-07" version="1" precursor="true">MKINRRSFLKKTAAATGALSIPTIVPSSVFGKNAPSNRVNIGCIGVGNQGSGLMKNVLYNDQAQVVAVCDCFASRRQAALDTIKDIYTQTGKESRINAKAYADFRELLAREDIDGITVATPDHWHVPIACHAVRAGKDMYVEKPLGVSMKDGFKLRNLVRDKKAIFQYGTMQRSDHYFRFACELVRNGYIGQLQKMDVWCENIGDHQYTKTMPKTQPVPEDLDYDQWIGPAPMKPYCDVRVSNLGAWHIYDYALGFIAGWGAHPLDIAQWGNNSDDTAPIHYEGTGTVPSGGLFDTVSFWDLHCTYANGVKMHFMDHATAIPVVSKYHPELRRHGTTFHGTDGWISVRRGAIDFSDETLRRVKLKEDETHLYNSKTHMGNFIECIKTRKKPISTIEAAVQSDLISHLSNAVVRLKRPIKWDPKNERIINDQEATKMLDRPKRSPGRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP5</accession>
    <name>A0A1U9NJP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01308"/>
    <dbReference type="EnsemblBacteria" id="AQT68153">
        <property type="protein sequence ID" value="AQT68153"/>
        <property type="gene ID" value="STSP2_01308"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01308"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="384" mass="43068" checksum="FEAAA8B03730DEB1" modified="2017-06-07" version="1" precursor="true">MSVRKSLMIIGIAGFCAVLLFSAGCFKAKGGFGRYSEEEMQEIDLAQRDNLPVPTGGLVLSVRGEAISVDEVIEPLQSGFEKIAGTNFQTFVEQSRPAVSRVVMNKVTDILLYNQAQRKAGDNAQMEDKLEQAVESEVDRFIVEWGGDYAKAQAAIEEMGMDWKSFREYQKRMLLTQSYLGEKLKSETEVVSRRRMKKFYDENQELFEQKGVLDFKLIDIRPEKLADEQVEEGQDRKDAAIQLAGSLYARAKAGDDFGELAEEYSHGHMAISGGDWDAVTPGSLAAPYDAIEEAAKDMEAGELSGPIVADGHVFVMQLEEYRAGGVVSFAEAQDKIEYQLKTQRRREQFNEIIAELMEQANVQGMDRFVEYCLVEAYNRYAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV5</accession>
    <name>A0A1U9NJV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane assembly lipoprotein YfiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68014">
        <property type="protein sequence ID" value="AQT68014"/>
        <property type="gene ID" value="STSP2_01168"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01168"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="634" mass="72951" checksum="371AEF50D6321616" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX8</accession>
    <name>A0A1U9NJX8_9BACT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68044">
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        <property type="gene ID" value="STSP2_01198"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="528" mass="57381" checksum="0152B0E94938B7F0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ6</accession>
    <name>A0A1U9NJZ6_9BACT</name>
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            <fullName evidence="2">Transposase IS116/IS110/IS902 family protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">STSP2_01219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68064">
        <property type="protein sequence ID" value="AQT68064"/>
        <property type="gene ID" value="STSP2_01219"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="39943" checksum="DE4C66469778CB4F" modified="2017-06-07" version="1">METILAIDLGKNKSVFCQMDRASLKTKYRTVRTRPELFHDIFAELNANSSIVLFESGNQAGWLADMLRAMQLPFKVAAWKWTNNPVKSDKKDAKRLAVMYHHGFFPEVHVPVKKVRQKRSLINYRQKLVTRMTQIKNSIRAIMCSMAIDLPAGRNCWTKKHLETISQHASPLKQIDDPCQLWRGQLHAELQQYKIVQQQLDRVTAKLDALGKKDPATILISNAPGIGPRTAEAVSAVIDDPHRFKNARHVSSYVGFTPRRYQSGEMDRTGRISKHGNPLLRMLLVQASWASLQYAWAREIYDRVCRGSAKRRKIAIIAVARHMLIRCWAMLRDNKPWRHDRCKVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK13</accession>
    <name>A0A1U9NK13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67920">
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        <property type="gene ID" value="STSP2_01072"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000189674">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="224" mass="25490" checksum="1BD2B3AF932E487D" modified="2017-06-07" version="1">MIGNAKPLGLYLGRLRLAFDLAFRSCLRRKRGQVDNEQFKTYIRSLVECKARQLVGKCGIRKCDVEDIEQELFLHLLLRASEYKSSKSKLTTFAQRIIERKVKNILRDRSAGKRSTFDQARSLHEVIGSDDQGTEITLLATIPARDVPSVEFATDVKMIIESLPVLHRKVCLMLMAGFTIGSIADQLGMPRTTLRDSIVKEIRFAFSELKNFSDFRRFGNSPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKC3</accession>
    <name>A0A1U9NKC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acsE</name>
        <name evidence="2" type="ORF">STSP2_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.258" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01509"/>
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        <property type="gene ID" value="STSP2_01509"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="317" mass="34970" checksum="55D23F2CDCA3DFAF" modified="2017-06-07" version="1">MTDRLISIAESLHASIPSTRRVMDSLHELGPDCFSDKSEPLGEIKKIIQSQADEGADFIAVNVDAYGEDDPHKTIEYMREYVKLIKQFGQGVPPCIDSSNDDALVAGLKAWYEDNAQAAVPLINSIKTYNADKLMPLRDKFEYSFIAMLVAEEKGACPGGVDGADELVGLAKQIFDKAIGYGFKPDQIYYDTTVFPLAIDMPMQPGVPSYTHRAFETIRRIKQDPEMAGVHFSLGISNCCRDLPGRKIGICRAYVEKAMEYGLDAGIVNVFHHYGEKPADPQLVELVDAFAAIDGDDPAMTNDAMMKMSQFCSSFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI8</accession>
    <name>A0A1U9NKI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68317">
        <property type="protein sequence ID" value="AQT68317"/>
        <property type="gene ID" value="STSP2_01476"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01476"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012007528" evidence="1">
        <location>
            <begin position="27"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="400" mass="43547" checksum="E0C74E9B91FCD627" modified="2017-06-07" version="1" precursor="true">MNSTSTKTTVVLLVMAVLAGSVIAGAQNTGQAMEAMANRLVDNQNVDGFWNAEPYHTGSIVPGLVAGYEYACDQSYLDAAGMACEFIIWEAQGNYFGDEAYALVQYGDVADEPYYLTEVYDFYQWVDEVLLGSTEQYIADFENGTEPSSAVFYVAHHTVAAYAVDSPAKYKWRQGLRHHLARVDDTSSFPLMGMAVAAWAFAQTDAGLDSTPVTPAGETPASDYWDGVTLADLPGKVADLQVQRAQNDGTFFEKLLPEENGFESGYSEDTIYAVLALQQAKEAGIEVNYSVADAREKMLGGIEMVTNGSRLLGKVYGHLTDPDPTDTYHFYAGKMLSALDAASIPTDLNGDDVIDIKDLEILAANWLSDSGCQCERVDINDDGVVNYPDFAEIVKNKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ1</accession>
    <name>A0A1U9NKJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Marine proteobacterial sortase target protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68419">
        <property type="protein sequence ID" value="AQT68419"/>
        <property type="gene ID" value="STSP2_01579"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01579"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="134"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33667" checksum="17B4B932250261DE" modified="2017-06-07" version="1">MDQRKENILASMYSPARPSRRWAWAVSIALHLCLFGVFAAINLHDANGQSERVGVSKANIKAIQENSLTVPKPNIKPPSTTAAKQALRPDAAEKPAFLRSPQEDRPEPAVQTLATPAIAQPRTEFFGSRTSQRKICYVVDCSGSMLGFFSRVRDQLAASINSLKPDQYFYVIFFHGDELIESGDGRFKRASRSAKAEAIDFVRSIRPGGATNAERALRRAMLIRDHSGNPAQQIYFLTDGFDFASPDPDVVSTFTRDILEKVRLLAPRVRISTIGFWVEPADEEVLRSLARLTQGDFVNLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKK7</accession>
    <name>A0A1U9NKK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68472">
        <property type="protein sequence ID" value="AQT68472"/>
        <property type="gene ID" value="STSP2_01636"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01636"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013182905" evidence="1">
        <location>
            <begin position="25"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="574" mass="62158" checksum="B7351FB33D76EDA1" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM4</accession>
    <name>A0A1U9NKM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01446"/>
    <dbReference type="EnsemblBacteria" id="AQT68288">
        <property type="protein sequence ID" value="AQT68288"/>
        <property type="gene ID" value="STSP2_01446"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01446"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17716" checksum="A02CB2173FB96862" modified="2017-06-07" version="1">MSTNVQNITLGGIGGQGVVKASEICGWAAALAGFHVKKSEVHGMAQRGGSVESHVRFGEEVNSPLVAEGRADYLVCFHEDEHNRLKVFLKPDGVDLAGYLSKAEDVIENPRYLNTFLVGVLSAKISDIAEEHWLAAIAKVFAAKYLEENTRVFMEGRRISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKM7</accession>
    <name>A0A1U9NKM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-anchored protein predicted to be involved in regulation of amylopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01623"/>
    <dbReference type="EnsemblBacteria" id="AQT68459">
        <property type="protein sequence ID" value="AQT68459"/>
        <property type="gene ID" value="STSP2_01623"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01623"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="110"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="815" mass="94299" checksum="C8F48B5FDC06165C" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKR6</accession>
    <name>A0A1U9NKR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68405">
        <property type="protein sequence ID" value="AQT68405"/>
        <property type="gene ID" value="STSP2_01565"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01565"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19726" checksum="5D5BC1DF5DC8573E" modified="2017-06-07" version="1">MNRTHQLAKLALALIGIYFIVLAVPTPITYIMVIISGGAADSANILQIFIGTLIYLGYMYLLYFLLIRKRACFAEKIVPEADQSEPGSPSQWIPLVYRLTCISVGIYLSALVITNITSIINNWILHRQIPDGVYSAPNSYSSIFLIPLAAYLLAGAPHFVRWQTRKTLEFCKTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT2</accession>
    <name>A0A1U9NKT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">etfA_2</name>
        <name evidence="6" type="ORF">STSP2_01707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01707"/>
    <dbReference type="EnsemblBacteria" id="AQT68541">
        <property type="protein sequence ID" value="AQT68541"/>
        <property type="gene ID" value="STSP2_01707"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01707"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="37391" checksum="99198BE22082076D" modified="2017-06-07" version="1">MIQVNRSGEVWVFAEQREGDLEDVAIELLSKGRELADQLGVKLAAVLLGDKKAEGLTEKLGHFGADKVYLVVNPLLEHYQTNSYTKVIHDLIHKYEPQVFLCGATVCGRDLAPRVASATKAGLTADCTDLQIGDHEIRRTGEVHKDLLFQIRPAFGGNIIATIINYDRWPQMATVREGVMPMPEPDGNRKVEVVRDEAHLGTQDLALEIINQHIEEKKVNLKGARVIVTGGAGVGSKANFKKIWDLAHCLGAAPGATRAAVDLGFIDHDHQIGQTGTTVRPSLYIAVGVSGAVQHVAGMSDSKKIIAINKDPNAPIFKVAHYKIVGDLNQVVPRMIDSIREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT4</accession>
    <name>A0A1U9NKT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate synthase subunit PorC</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">porC</name>
        <name evidence="3" type="ORF">STSP2_01585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01585"/>
    <dbReference type="EnsemblBacteria" id="AQT68425">
        <property type="protein sequence ID" value="AQT68425"/>
        <property type="gene ID" value="STSP2_01585"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01585"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19104" checksum="28D3238CA1A902A6" modified="2017-06-07" version="1">MQTTETKIAIAGFGGQGIVLAGNILARAAVLEKKNVTGMVSYGVEMRGGTANATIVISDDEIASPVVERPDAAMLLNQPSVDRFVPAIEPGGVAIINGSLASCKLDRDDLDVCCLPAGELARSLGNIRVANITALGAFVAMTEVVKMSNVVRAIEDLFGSKKPQLLAINDKALEAGAKAAAKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKT7</accession>
    <name>A0A1U9NKT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01497"/>
    <dbReference type="EnsemblBacteria" id="AQT68338">
        <property type="protein sequence ID" value="AQT68338"/>
        <property type="gene ID" value="STSP2_01497"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01497"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15902" checksum="1F022930DC3BBFC6" modified="2017-06-07" version="1">MKFHPIRLTLSIAVILGMFVVTHIPQDRMSVDLGTFGFDKLLHAGAYFIITLSVLWSFEGRHRLFLTTVACTVASWGAFDELTQPMFGRTTSAGDWLADCVGVGLAVLLYRGIKMISDKQKQQEIDPCEEYIEISVEENKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV8</accession>
    <name>A0A1U9NKV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68437">
        <property type="protein sequence ID" value="AQT68437"/>
        <property type="gene ID" value="STSP2_01601"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01601"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10964" checksum="8210A89FD13F363E" modified="2017-06-07" version="1">MLAFFIHHEGHEGARRRYRGKKNMESLRDGFFMLGPPAADDKEGVWFNRKEDEEGNRGRTDKNMESLRDGFFMLDPGSGSGMTTAKICVLFCKGLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW6</accession>
    <name>A0A1U9NKW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilD-dependent protein PddA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xcpT_4</name>
        <name evidence="2" type="ORF">STSP2_01311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01311"/>
    <dbReference type="EnsemblBacteria" id="AQT68156">
        <property type="protein sequence ID" value="AQT68156"/>
        <property type="gene ID" value="STSP2_01311"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01311"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027558">
        <property type="entry name" value="Pre_pil_HX9DG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04294">
        <property type="entry name" value="pre_pil_HX9DG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="266" mass="30515" checksum="491E37D10E44480E" modified="2017-06-07" version="1">MRKVERKGFTLIELLVVISIIALLLAIMMPALGMVKEKAKFVVCRTNLKSIILGSKLYANDNASKMPSYNYNGLWINDISEYMEDVDEARYCASTKVKEERAEDVADQSYDFGDARTAWMWNWGTNEPEYGSYSINAWFYDYNEAQVEGFTPEQRAALWKNLGNVRQASNVPLFADSKWLDGRPMDTDYIPEDYDLGGRSTTAGGSMCRYIMDRHGKQTGVAFVDGHVDAVALSDMWTLKWNRTWRAKQDVKRGENWDGTPIYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX6</accession>
    <name>A0A1U9NKX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68240">
        <property type="protein sequence ID" value="AQT68240"/>
        <property type="gene ID" value="STSP2_01396"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01396"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="271" mass="30540" checksum="FF56D341A6FB71CC" modified="2017-06-07" version="1">MKNSSNSHNTHSDRNIAKSNLYSAFRQELEKSIDEYRSEAAEGYAGRNLSKADYIDSVICHFLSDLFSRIKPIPKVLEIPEEEAYVSANDILNKLGPTGVTIGAAVFRLAHQLEIELPANGIERASNSVVAFKEDGAKAYETAVPIVMCYEEFFWQDMDAVMKHIFYMKDKVVEKFGQESKEARIGLELMELPLMSQRLVVVAMQYLMEVLIGASIVESILEEYRRARSLQKNLSDGITKLPNEIYLDVHLILLHLGRILEILGVDAPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY7</accession>
    <name>A0A1U9NKY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfp pilus assembly protein PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68176">
        <property type="protein sequence ID" value="AQT68176"/>
        <property type="gene ID" value="STSP2_01331"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01331"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="16152" checksum="0ECFF382A4616D19" modified="2017-06-07" version="1">MRTYGKNKGFSLVETVAASVLLSLAVVTLSTISTRSVLNVKNNREYEQAWEILNRQLTYIDYMGVEAFMEQGEFSGKLGDEESGETVHEWAVDINESSDYTGLYSVDIKITWGPERGRRSVSASTLLNEDTSESELELLETQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL85</accession>
    <name>A0A1U9NL85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComE operon protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comEA</name>
        <name evidence="3" type="ORF">STSP2_01838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01838"/>
    <dbReference type="EnsemblBacteria" id="AQT68669">
        <property type="protein sequence ID" value="AQT68669"/>
        <property type="gene ID" value="STSP2_01838"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01838"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12393" checksum="3D8D97F6EB41C5DD" modified="2017-06-07" version="1">MEAFDEGVGSGEQRRKLLAACVVGAVLGGLFFAQCVIVAGGGTPVVEDRIDVNAADAESLVRLPGIGPSKAEAIVEYREEARKFERVEDMEDVKGIGPKTVEKLRPFLRFDENAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA0</accession>
    <name>A0A1U9NLA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">STSP2_01883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01883"/>
    <dbReference type="EnsemblBacteria" id="AQT68711">
        <property type="protein sequence ID" value="AQT68711"/>
        <property type="gene ID" value="STSP2_01883"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01883"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="238"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="746" mass="84367" checksum="38F2B99E44FF5D60" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLC7</accession>
    <name>A0A1U9NLC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68538">
        <property type="protein sequence ID" value="AQT68538"/>
        <property type="gene ID" value="STSP2_01703"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01703"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14496" checksum="27A80F81BFDC6848" modified="2017-06-07" version="1">MPADELRRFVIQKHTRPGDTHWDFMLESGQSLLTWRLPECPAELAKSPDCPAVKIFDHPLRFLTYEGPVNQGTGDVKIEEAGTCLFHENRAGLISFELHGELLDGQFELRRQEDDRWLLKRLGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF7</accession>
    <name>A0A1U9NLF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01805"/>
    <dbReference type="EnsemblBacteria" id="AQT68637">
        <property type="protein sequence ID" value="AQT68637"/>
        <property type="gene ID" value="STSP2_01805"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01805"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="346" mass="38757" checksum="E208D0FA3729A044" modified="2017-06-07" version="1">MTTSKEQLKRAVLWQPESDNKARCYLCNFRCLIPEGKYGHCAVRQNVNGTLRSLNYDSVCAANPDPIEKKPLFHFQPGTRSFSIACPGCNFQCTFCQNWQISQMALKYHQLEGEPIPPEKIVAAAQRSSCCSIAYTYTEPTIFMELCEETGKLAKQQGLTNVFVSNGYMTKEAVDFSAEWLDGINIDLKAFSDKYYKDLCNARLQPVLETIKYIAKETDIWVELTTLIVPDQNDSDDELKALAEFIANEAGPEVPWHISRFFPAYEMDGGSATPPETLERAMEIGKQAGLKYIYVGNLPGSNAESTFCPSCGEKVIDRISYIIRRNNIKHGACPSCSEKIPGFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG4</accession>
    <name>A0A1U9NLG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68773">
        <property type="protein sequence ID" value="AQT68773"/>
        <property type="gene ID" value="STSP2_01945"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01945"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12758" checksum="521F667DA4806B56" modified="2017-06-07" version="1">MDQFLDISLVIPVFVILLVIIFHTIRTSLCYNLPISITLATCVSILAVVGMVRQFGDSIGVILLPYTAMALTILLISILLFLVRFLRQAKERFRKNTSTDENKKESNERMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH0</accession>
    <name>A0A1U9NLH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68781">
        <property type="protein sequence ID" value="AQT68781"/>
        <property type="gene ID" value="STSP2_01954"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01954"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13390" checksum="645F180CC5B38D30" modified="2017-06-07" version="1">MLSEKSEAAAGTTAPQRKTKSTGDYHFCPSPSSSKRAEKIAQRRSDMPRSYQAKYARAVSGKSLRAAVDSFCLECMMWQRNEVRKCTSLACPLWAYRPYKPQQKLQTSVIHKNGDKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI3</accession>
    <name>A0A1U9NLI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68791">
        <property type="protein sequence ID" value="AQT68791"/>
        <property type="gene ID" value="STSP2_01964"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01964"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="436" mass="49091" checksum="540ECE061CDA437D" modified="2017-06-07" version="1" precursor="true">MDNQNKLTSAGRVFFDSGLNDPETFMSNILKKNFVFIFVSLFLILAQEKSAADAGDPAESLQQKYSADASDDCNEKLLKTAFDVASKIPVDPHIKDRSKAQQKVVGTCLLLDRPHLAVKFIEGIKNWRQGLCYAEMGLYYAKRHNELKAKKWLGMADMVANEVEDWRKNRINIKVAQIYSWLGKAGEADRIESTLEAGEKGLIESGTITSNPNKTIEEQMHELDEHIATGNFDAVKNSLFAYANIYREKYADTDIRSKVEEKIKFSWKPIPVFIRIELLCELAEAAVDNEDEQKAMDLLKEIQQLLDAYDWPVRHLIPMGARTALLRAKAGNNANAVSKADTLLKLYEDKESSIVDIYKAETLIPLAEAYHSMGQDGRSLSVYRKALLAAFENPNSRPRAEDLSAICCSMALNGIELDKELWGLIFELSNELGQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM6</accession>
    <name>A0A1U9NLM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68735">
        <property type="protein sequence ID" value="AQT68735"/>
        <property type="gene ID" value="STSP2_01907"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01907"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="40201" checksum="2D5DB921474C71F4" modified="2017-06-07" version="1">MPLYLPDDFWLLADSLWTDFVISFTLFTSVCYAVLSRRLNHHRPAAAASTAIGLALSLSLTFWQSANNFSLADLGPLAVSFAAVVIAVVIFGVFRQVVGSLPAAMLSFGVCLVTALSPGLNPPISHDLIALVAFLIVAAALYMVLTNHGQPRIYPQSTPPQSSPDKQRQPAQLSASIEKQICQAEQNSTRLENDPQNIGQLQRQIEDILPKTSALTDQMARLRKQAAFVKNGQLQRIKKLRMRLMRTPPEQRAAVAANMKKAYKELKFDDRIERLDYAVAETEKRVRDCLNRSIQLLNAGDTAGLIRMLDRARRLQRHNQKLETVIERSKEKLIGQYDQFEQSQSRNYTKQEIKGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLP3</accession>
    <name>A0A1U9NLP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Internalin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">inlA_3</name>
        <name evidence="3" type="ORF">STSP2_01823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68654">
        <property type="protein sequence ID" value="AQT68654"/>
        <property type="gene ID" value="STSP2_01823"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01823"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="436" mass="48193" checksum="F5CEB770944EFBF0" modified="2017-06-07" version="1">MMKNCKLWFLLAFVVVVLFLSRSYGITFEEWARQEGLTGEEKQIADIFNRMHSLEGLAGNYTELERLILIGSVPGFEIIDVGDFAGLDKLRSLSLESSGVENIAPWAFAGAENLWYLNLSKNHNLKTSANAFQGLSHLEDLLLSSCYINNIATDAFSGLKSLTKLDLQSNKITDVHAPSFQGLHNLKLLNLRSNDIRSIDNGDFAVFTNLQELNLERNRIGSIERGGFSGLNNLRMLKLAENQISCLKLGRFEGLSSLLELSLRKGTVDDIELGAFAGLTSLEKLDLQNNRIDKLNVGSFAGLANLRKLDLTYNSIGSLKAGHFAGLDKLEELHLRNNAICEVGPYAFTGAESLLNLTISGTEIELERGAFAGLGKLEILRMGFNRIESMESGLLSPLVSLKNLFVTSGDEMGLLNFEGANFAELEWLDPEKLYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ6</accession>
    <name>A0A1U9NLQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose 2-epimerase</fullName>
            <shortName evidence="3">CE</shortName>
            <ecNumber evidence="3">5.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ce</name>
        <name evidence="4" type="ORF">STSP2_01937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-cellobiose = beta-D-glucosyl-(1-&gt;4)-D-mannopyranose</text>
            <dbReference type="Rhea" id="RHEA:23384"/>
            <dbReference type="ChEBI" id="CHEBI:17057"/>
            <dbReference type="ChEBI" id="CHEBI:47931"/>
            <dbReference type="EC" id="5.1.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cellobiose 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.11" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1U9NLQ6"/>
    <dbReference type="STRING" id="1936003.STSP2_01937"/>
    <dbReference type="EnsemblBacteria" id="AQT68765">
        <property type="protein sequence ID" value="AQT68765"/>
        <property type="gene ID" value="STSP2_01937"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01937"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047736">
        <property type="term" value="F:cellobiose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00929">
        <property type="entry name" value="Cellobiose_2_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028584">
        <property type="entry name" value="Cellobiose_2_epim"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="427" mass="49873" checksum="1AD169DB8259C08B" modified="2017-06-07" version="1">MEIIKQFKKYREIFEKELTGNILKFWNSHIVDDTNGGFFGALDREGRPDLTAPKGCVLNTRLLWTYSACARLLNDEQCHKLAKRAYETILCHFEDLIHGGFYMELDAANRPLNTVKHTYAQAFALYSLCEYYRLTGSSEVLKKVQSFFYFLENKTKDPNGPGYLESFTRNWECIEENRMADGNEPKSMNTHLHVLEAYAAVVRVWNDPVPRERLRELLTIFSDYIIRPDGHFGIFFEKDLSESSKSNGIISFGHDIEGSWLLWEAVEILQDESLLDKWRSIVTKMARATERVGLDVEGGMFLESYRYGSHVRTNMHWWIQAEALVGFMNAYQLTGDEHYWENVKLSWSFIDKYVIDHEYGEWFTKVNRLGKPFLEEPVDDPSPYYRNDRKADLWKCPYHNSRACLEMVSRIDATLESVEETVKNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLT7</accession>
    <name>A0A1U9NLT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">epsF_3</name>
        <name evidence="11" type="ORF">STSP2_02089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02089"/>
    <dbReference type="EnsemblBacteria" id="AQT68912">
        <property type="protein sequence ID" value="AQT68912"/>
        <property type="gene ID" value="STSP2_02089"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02089"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="239"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="372" mass="40406" checksum="E825653E8AB447F3" modified="2017-06-07" version="1">MNPGTLAIKHATISKKAEVSPIKVKQSDLILFTTQLSVMLDSGVVLSDALEAISVQVGPGAFQDMIEDIAERIKNGECLSNALACYPRTFNAMFISMVKASEASGNMSHMLEVLSGYLSSDAQTRKQVKGAMIYPFVMLLTAVAATGSLMFFVLPRFTKIYAAKGAALPGMTQALVNFSKFMGNTTVMAATTTLIICAAIFIHYWKQTVNGQKTLDWIKVHTPIFGPMFVDLIVTRSMRILATMVNTGVSLLDSLEVMQMSCGNYYFRRLWQATDSKIRDGYQLSEAITVAPNSDLIAPGILQMLKAGEKSGKIGSVCEKVSIFYEKKLQNSIKTATALIEPVMILVMGGIIGTIAIALLLPVFRISSVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV4</accession>
    <name>A0A1U9NLV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermophilic serine proteinase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68718">
        <property type="protein sequence ID" value="AQT68718"/>
        <property type="gene ID" value="STSP2_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01890"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
        <property type="entry name" value="Peptidases_S8_Subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002102">
        <property type="entry name" value="Cohesin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034204">
        <property type="entry name" value="PfSUB1-like_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00963">
        <property type="entry name" value="Cohesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="1384"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1961" mass="214674" checksum="BAD756FE93D06066" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM23</accession>
    <name>A0A1U9NM23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02140"/>
    <dbReference type="EnsemblBacteria" id="AQT68963">
        <property type="protein sequence ID" value="AQT68963"/>
        <property type="gene ID" value="STSP2_02140"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02140"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="563" mass="62040" checksum="524088CAC35C9953" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM75</accession>
    <name>A0A1U9NM75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69031">
        <property type="protein sequence ID" value="AQT69031"/>
        <property type="gene ID" value="STSP2_02211"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02211"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10867" checksum="CC1641989F01B858" modified="2017-06-07" version="1">MRLRRRMCFVNLIGQVRFYQRNFLLRSQAVVGFQQSAKAFDALDFGRFVKLVLCFDDPAQRLVNAFVVIIVAVLIEHVLELFDGRQNQMIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA2</accession>
    <name>A0A1U9NMA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">STSP2_02040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02040"/>
    <dbReference type="EnsemblBacteria" id="AQT68864">
        <property type="protein sequence ID" value="AQT68864"/>
        <property type="gene ID" value="STSP2_02040"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02040"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="254" mass="28670" checksum="311F48FD0E3B0885" modified="2017-06-07" version="1">MEKTRHAKLNLDRVDNADRLAERALDVFCEDASRAIQEKGVFTVALSGGHTPVRFFELLGSSEQANSVKWDSVHLFWVDERFVSPDSEDSNYGLAASTFLDKVGIPEQNIHRISGEETEYSKAVDQYEDQIKSVFDLAAGEKPQFDLLVLGMGADGHIGSLYPNSVVLFDTEDIVSPVYFMGENINRITLTYPVIRKAEHILIMISGRGKAETLRDVLTSEPDEVRYPVHTLWPILEKVTWLVDQEAAQYLEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH3</accession>
    <name>A0A1U9NMH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02111"/>
    <dbReference type="EnsemblBacteria" id="AQT68934">
        <property type="protein sequence ID" value="AQT68934"/>
        <property type="gene ID" value="STSP2_02111"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02111"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012279003" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="125"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="732" mass="78867" checksum="0C140FB7C3049E9B" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ9</accession>
    <name>A0A1U9NMJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP-CTERM protein-sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68964">
        <property type="protein sequence ID" value="AQT68964"/>
        <property type="gene ID" value="STSP2_02141"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02141"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="2">
        <location>
            <begin position="70"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25408" checksum="86155E5F69B8298B" modified="2017-06-07" version="1" precursor="true">MMKARVILSMVVVALVAQVSFGGLVGQWTFDDPQNPGGTIYGDPVFSSGDMILDGDDGLNTGINGVAGAGARTISAWVKVDDGNYGGSIISYGDHSATGLGTRFTFKINNDSGVLRCEIAGGFSIGTTSVTDGQWHHVALTTAEGDGDTANVKFYIDGQQDAVADYGNANPIDSDAAEMSIGYSKAFYDLGWAGAMELIGGLDDVRVYDEQLSSSEVAALVPEPATMSLLAIGAFGLISSRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMQ2</accession>
    <name>A0A1U9NMQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68786">
        <property type="protein sequence ID" value="AQT68786"/>
        <property type="gene ID" value="STSP2_01959"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01959"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12338" checksum="2A83D26CF807DB29" modified="2017-06-07" version="1">MRKVSNKWAKRLSWYCLIPPAMYVLVRLINEEARIYAQDLASTLAGAAFLIGIVWGVYGIACLLSPSWVKCENCAFAELAEDTDKMYCRAKDFQYARDYSCPQGRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMR6</accession>
    <name>A0A1U9NMR6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amtB_1</name>
        <name evidence="11" type="ORF">STSP2_02431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02431"/>
    <dbReference type="EnsemblBacteria" id="AQT69242">
        <property type="protein sequence ID" value="AQT69242"/>
        <property type="gene ID" value="STSP2_02431"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02431"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013182906" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="28"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
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            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="261"/>
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            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00909"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="AQT69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="48462" checksum="04530658F01AE491" modified="2017-06-07" version="1" precursor="true">MLMKNWFPKSLAALGLILALCSNTALADSTSEAANVDLNLVTEQLQNNINIAWTCLAAFLVFFMQAGFAMVETGFTRAKNAVNIIMKNLMDFSIGSLAFFVVGFGLMFGASNGFWGASDFAMFNLPADDKDWSYTFLLFQTVFAGTAATIVSGAMAGRTKFKSYLIYSVFICGFIYPIFGSWAWGSLFNGGGWLEKLGFVDFAGSTVVHSLGGWLALAGAIVLGPRIGKYGPNGKSNAIMGHNITLAALGVFILWFGWFGFNPGSTTFGDGAIGRIALTTNLSAVAGAITAMATTWFITKKPDASMSLNGALAGLVAITAGCATVTPNGALWIGAISGVLVVLSVIFIDSVLKIDDPVGAVSVHGVCGMFGTLACGLFNAEGVIGTGDSTGLFYGGGIGQFFVQAAGAFACLAWAFVVGLAMFMLIKKTVGIRVTAEEELKGLDITEHGMESYSGFQIFSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN22</accession>
    <name>A0A1U9NN22_9BACT</name>
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        <submittedName>
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        </submittedName>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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    </evidence>
    <sequence length="1057" mass="118751" checksum="18416FF52FBD6435" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN52</accession>
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    <protein>
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            <authorList>
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AQT69040.1"/>
        </source>
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        <source>
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    <sequence length="149" mass="17938" checksum="869AE176570D05DD" modified="2017-06-07" version="1">MAKKQQKKTAKGGKKSLCDKCTGLCCRYFALPIDTPEDWDDYDDIRWYLNHEDITVFVEDGDWYVQVANKCKYLSEDDYKCQMYETRPKICRGYSTENCDFTSDDYDYELHFTDEHQMEEYMKIKFGPKVFDKLNPRKRKKKAKKRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Bunk B."/>
                <person name="Sproer C."/>
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    </dbReference>
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        </location>
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            <end position="232"/>
        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="252" mass="28676" checksum="49E04D4C90C4761D" modified="2017-06-07" version="1">MSLSTEKIERLLRMVDADQECDTVYAQNITHFLDEDEIAECERDQLLLFTGYSEYITCTQCFHQPCTVSPKILRYPDGSKWGVCICGENERLEFPIDQLRCWDLNITRAKELLPTQKDDEQATAKGPNKQTAKKKKRPNQKEMADRNRAVALAAAELKSKYGRLPTVSEVAAETSYEPKHIYPTDPYKEGKIAKKTSKATKQMTGSSVTSSELFGRNSLEQSRANRRSKSDQAHLEALINEQIEDENSDFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC7</accession>
    <name>A0A1U9NNC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core-O-antigen ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51770" checksum="59FC5377B644E84B" modified="2017-06-07" version="1">MTAITMIIAALGSGLVILAQPIWGLIIYITLLAWYPSYLKVSLSGIDFSVGRIIILAVFLRILMHSELLSRFRLNTADKLIIVYFAAQTVAGMFTESEFNAFIVNRGGAAFDMALPYFAFRIVVCSAQDYRKLFKGILFTLGPLAMIGLYQSFTGVNPFGFMQKFASTGRLPDYTPLPRHGFYRANLTFGVSIMSGLFFAMLGTAAIGLIPAKDSPARRWWLIGLICMAAGVFSSISSGSWLVGMVAVMFVFFYPYRKYWRGALFAIVMLLLSVEIYSNRNFYDVLGSFTLNPRSAWYRAQLIEVALFKGGMEDHWLAGYGHEDPGWSKQIDNRDHTDMVNHYLMVLSRYGLLGLIPFMALLYFVLKYLYLAFQMARNFAGKFMVWGLTGAILGTMATFFSCSLFSQPSTAFYVLLALGASMPTIVARSEFARRRAFFEEHKRMLAMTQDTGASKVPAQQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNJ7</accession>
    <name>A0A1U9NNJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01675</name>
        <name evidence="3" type="ORF">STSP2_02503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01675"/>
    <dbReference type="EnsemblBacteria" id="AQT68510">
        <property type="protein sequence ID" value="AQT68510"/>
        <property type="gene ID" value="STSP2_01675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69314">
        <property type="protein sequence ID" value="AQT69314"/>
        <property type="gene ID" value="STSP2_02503"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01675"/>
    <dbReference type="KEGG" id="alus:STSP2_02503"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="71"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="26937" checksum="FF02D7B8D650A48E" modified="2017-06-07" version="1">MALSYYPTMINKYKKRSKISEAKFRQIVKLFALDIEATKIAELTGLSRKTINTILYKIRIRIAEYCQQQSPFDVGEIEIDESYFGARRVRGVRGRGAKGKHIVFGLIKRGGKVYTQVVRNCSKSTLMPIIKQKVDKDSIVYTDGFKTYDGLVDFGYKKHYRVKHGENEFAEGHNHINGIENFWAIAKGRLNKFRGISKGTFALHLKECEFRFNHRHDNLYKLLLKILRKNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNQ1</accession>
    <name>A0A1U9NNQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent transcriptional activator MalT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malT</name>
        <name evidence="3" type="ORF">STSP2_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69465">
        <property type="protein sequence ID" value="AQT69465"/>
        <property type="gene ID" value="STSP2_02655"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02655"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="124" mass="14538" checksum="89E22780B5BB8690" modified="2017-06-07" version="1">MSTKTMDKQAKVSRSSEYHLPSTVLLDNKQWLYIQRRYRMTPREVQIVKLVCQGLSNKEIADILDVSSGTIKAHIRNIYRKSWVHTRIEMLIRFLEDVAAANIEPDDYDHSYSRIKENTSHIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNR5</accession>
    <name>A0A1U9NNR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mntR</name>
        <name evidence="6" type="ORF">STSP2_02557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02557"/>
    <dbReference type="EnsemblBacteria" id="AQT69368">
        <property type="protein sequence ID" value="AQT69368"/>
        <property type="gene ID" value="STSP2_02557"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02557"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17755" checksum="3A1ED4BE7E9E8AE8" modified="2017-06-07" version="1">MSPTTDYNLTASLEDYLEAIFNISAKGSVARSKDIAQMLDVSPASVTGALRTLAEKELVNYKPYGLVTLTPEGENEARRIVHKHNIIKLFFVDILGIDHNTAQQAACEAEHSFGPKIINKLVSFVEFFSRQSSQGTDLVKQFREFCNANDVGETIKEASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP08</accession>
    <name>A0A1U9NP08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lacZ_6</name>
        <name evidence="8" type="ORF">STSP2_02529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69340">
        <property type="protein sequence ID" value="AQT69340"/>
        <property type="gene ID" value="STSP2_02529"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02529"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956679" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="675"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1252" mass="142743" checksum="EA7C6BF184311285" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP12</accession>
    <name>A0A1U9NP12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02665"/>
    <dbReference type="EnsemblBacteria" id="AQT69474">
        <property type="protein sequence ID" value="AQT69474"/>
        <property type="gene ID" value="STSP2_02665"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02665"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="27279" checksum="0A67F952B20932F1" modified="2017-06-07" version="1">MAGFVAAALAYGRVTQIERSVTGLLGVMGKRPGDYVRRFNDSKAAELAGFKHRFNTGKDLAELFGVLQKVLVRFGSIENYFAETDRDEHSTIVPVLTAFCDHLSDLYEELYQKEVSRGVKYLLASPARGSASKRLNLFLRWMVRDDEVDPGVWQTISPAKLVVPIDVHMERLCRILGLYGRKTVSLKAALEITESFAKVRPEDPVKYDFSLSRIGIIDNCTGKLTEKCDLCELYGYCLRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD3</accession>
    <name>A0A1U9NPD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69578">
        <property type="protein sequence ID" value="AQT69578"/>
        <property type="gene ID" value="STSP2_02771"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02771"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6964" checksum="39616ED3D24EAB10" modified="2017-06-07" version="1">MFTRIKEILKYKHDWQIEKRDVTWYPSDRSCVRPDMKKVKPHQLPPLMVKKPAWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE9</accession>
    <name>A0A1U9NPE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69793">
        <property type="protein sequence ID" value="AQT69793"/>
        <property type="gene ID" value="STSP2_02990"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02990"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024779" evidence="1">
        <location>
            <begin position="28"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="351" mass="39777" checksum="CD03C0BD095DD136" modified="2017-06-07" version="1" precursor="true">MNIKRFTANRSLLLTCIIAAASSAASPAPRTSGTFAVQKNAETITLSHDSSNILTYHHATHPVPDHVDPLYRRSAFIHPLYSPTGRVLTRIQPPDHYHHYGIWNPWTKTRIAGRQVDFWNLGKGQGTVRFNRIESTTSDPNRCGFTVRHDHVQLKGPHAPRTAIDETWTVRASATTIHARKAWVVDLTSTLKNVLDVPITLDQYRYGGGLGFRATEQWQKDNTTVLTSKGKTRTDADGTRARWCSITGSFDDPQQTSGILFLSHPDNRRHPEPMRVWPENSVGGRGDMFFEFCPIRHKEWILEPGKEYTLKYRMIVYDGKIDTQTAEALWHNFAAPQNNVTQQQNSPRPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF2</accession>
    <name>A0A1U9NPF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysK1</name>
        <name evidence="12" type="ORF">STSP2_02791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02791"/>
    <dbReference type="EnsemblBacteria" id="AQT69598">
        <property type="protein sequence ID" value="AQT69598"/>
        <property type="gene ID" value="STSP2_02791"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02791"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="11"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="178"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32724" checksum="3AA2A49D3361A270" modified="2017-06-07" version="1">MAKIYENIVETIGKTPLVRINKLGAAGVTILAKIESFNPCASIKDRIAYAMIQAAEDAGKLKPDTIVVEPTSGNTGIGLAFVCACKGYRLMLTMPESMSVERRRLLKMLGAELVLTPAEKGMKGAIEKANEIVNSTPNAFMCQQFENPANPEIHRKTTAEEIWQDTDGQVDILVAGIGTGGTITGCGQVLKERNPELRVVAVEPESSAVLSGDQPGPHKIQGIGAGFVPGILNTDVYDEVLRVGNEKSMEIARELAAKEGILAGISSGAALYAAIEVSKRKELQGKTIVVILPDTGERYISTELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPJ3</accession>
    <name>A0A1U9NPJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsA_19</name>
        <name evidence="6" type="ORF">STSP2_02616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69426">
        <property type="protein sequence ID" value="AQT69426"/>
        <property type="gene ID" value="STSP2_02616"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02616"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="523" mass="60670" checksum="69291F67A947AB3F" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL8</accession>
    <name>A0A1U9NPL8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">STSP2_03057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03057"/>
    <dbReference type="EnsemblBacteria" id="AQT69859">
        <property type="protein sequence ID" value="AQT69859"/>
        <property type="gene ID" value="STSP2_03057"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03057"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="273"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="446"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="524"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="651"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT69859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140070" checksum="01C19DC595038F64" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS7</accession>
    <name>A0A1U9NPS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69931">
        <property type="protein sequence ID" value="AQT69931"/>
        <property type="gene ID" value="STSP2_03131"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03131"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25624" checksum="B509E2D0C4CE2AB0" modified="2017-06-07" version="1">MRWIIVSAAFFGIAIVFAAACRDIKRTLERTKGAAKMKKRNKNKNKKNLAAQIYERGFELGMQGYTFQEYLREREKIRRELGGRLTGGQMEDVVQELRNGVVEGAECRLGKKQDESAADANDAVQRMFADGGMFADAVLSGDVGSGDCETMLEALGFLKAGPVTGSITPYDRADGVQFGRVLKDLCREQDEHMTITAKAKYLSIFENTFGERRWPEIKARMAERYGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPZ3</accession>
    <name>A0A1U9NPZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02875"/>
    <dbReference type="EnsemblBacteria" id="AQT69680">
        <property type="protein sequence ID" value="AQT69680"/>
        <property type="gene ID" value="STSP2_02875"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02875"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="275" mass="32097" checksum="913980076243247A" modified="2017-06-07" version="1">MKAEAFSNNFYAAGLNGLPERITVKGKDFQLWQVLKNDFFAVTGIYLIDPQQANSAPPKVVLKMARCRSFFGLPLKWLGKLMCRHEMRMLALVKEIPNVPQIYSPYGKYGFVYNYIPGNTLDDRPCLDPAFFDELRDLLKKIHQRNIAYIDMNKRGNIIVGEDGKPRLIDFQISRHIKTSPILPALSHYIRKHLQHADIYHLCKHKRKFQPHLLTSDELATYKNRPGWIKAHRLIANPYRTIRRSILRFLHKKCFLIPDKNANPTPETDPDRYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ14</accession>
    <name>A0A1U9NQ14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03005"/>
    <dbReference type="EnsemblBacteria" id="AQT69808">
        <property type="protein sequence ID" value="AQT69808"/>
        <property type="gene ID" value="STSP2_03005"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03005"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527465" evidence="1">
        <location>
            <begin position="20"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="701" mass="77790" checksum="F0D0A0606C328C48" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD7</accession>
    <name>A0A1U9NQD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70035">
        <property type="protein sequence ID" value="AQT70035"/>
        <property type="gene ID" value="STSP2_03237"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03237"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013024785" evidence="1">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28191" checksum="10675C1B5CAD5743" modified="2017-06-07" version="1">MKKQVLICISYICAAGVLQAIPVADNFDDGVLDTSKWISLDKDGAFVTEANGVVIFGTTDDTRPFLVTQGSWDPAVEGTLTVTGTVYIAADEAMVVWTRSNGEYDSVGWPNNGGVIGSGLRFSFANNEYNVNIMTKEDSVGWNAISSMTKNIENLSVVPGDWYFTVTDNGSQVSIEVVNAADPANYATATANTNFMPAVTSNKVVFGVSAGELDNITIAGEGDGDLTECIEWGYQISDLNKDCKVDLSDLVVFCSQWLNSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR31</accession>
    <name>A0A1U9NR31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70080">
        <property type="protein sequence ID" value="AQT70080"/>
        <property type="gene ID" value="STSP2_03282"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03282"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5228" checksum="6C3ABDF22D262747" modified="2017-06-07" version="1">MLQVLAFFVAFGICLAKGMGVLAALGVGFLAAIVWGIVFGLILAALSAMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR75</accession>
    <name>A0A1U9NR75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease AprX</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aprX</name>
        <name evidence="9" type="ORF">STSP2_03450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03450"/>
    <dbReference type="EnsemblBacteria" id="AQT70244">
        <property type="protein sequence ID" value="AQT70244"/>
        <property type="gene ID" value="STSP2_03450"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03450"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013296072" evidence="6">
        <location>
            <begin position="34"/>
            <end position="3724"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="8">
        <location>
            <begin position="352"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="8">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="2057"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="8">
        <location>
            <begin position="2567"/>
            <end position="2626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="3724" mass="396942" checksum="8EC3B9C5A8DD97B8" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRA0</accession>
    <name>A0A1U9NRA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispB</name>
        <name evidence="3" type="ORF">STSP2_03470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.90" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03470"/>
    <dbReference type="EnsemblBacteria" id="AQT70264">
        <property type="protein sequence ID" value="AQT70264"/>
        <property type="gene ID" value="STSP2_03470"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03470"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106350">
        <property type="term" value="F:octaprenyl pyrophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="336" mass="36378" checksum="AE7A889E59E622B4" modified="2017-06-07" version="1">MHGHNRTDNKNDGAGGESSPVPFFNALSEELKAVDYLLAGAIEPGEGDIAGLVANVRTSGGKMLRPGLLLLSGRIFDQSGERHIRAAAMVEMVHLATLLHDDVIDHATRRRGRETINCLYGDKAAVLLGGYVLGKVMALGSAEGMADMSGEVAAVARKICDGEMMQNVISLDHEIGEQNYYNIIASKTAALFGSACWMGAFLSGACKKDCNSLRQYGEHFGTAFQIADDILDVTSSVQKMGKNVGKDIFALKPTLPLIHFVQTVADGRELLHTAVYEDDRGRIRDMLSDAGSIEYAYEQAKMHSDKAVHSLTFIEADQTAMEPLLSLSRFAVNREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRD4</accession>
    <name>A0A1U9NRD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridylate kinase</fullName>
            <shortName evidence="10">UK</shortName>
            <ecNumber evidence="10">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Uridine monophosphate kinase</fullName>
            <shortName evidence="10">UMP kinase</shortName>
            <shortName evidence="10">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">pyrH</name>
        <name evidence="12" type="ORF">STSP2_03385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03385"/>
    <dbReference type="EnsemblBacteria" id="AQT70180">
        <property type="protein sequence ID" value="AQT70180"/>
        <property type="gene ID" value="STSP2_03385"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03385"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25846" checksum="9DED4F68B2B2A266" modified="2017-06-07" version="1">MSEIKYKRLLLKLSGETFCKPGEFGINGEYVERIAARIAALSKLGVEIAVVVGGGNFLRGEAFSEKSHIPRHTADYMGMLATVMNAAALQETLESIGQPTRVLSAIEVSAICEPFIRRRCLKHFEEGRVVILAGGTGNPFFSTDTCAALRAAELQADLLIKATKVDGVYTDDPMKNPDAKLLEEVSYTEVLQKGLKVMDPSAVSLCRDNNIPVVVLNIFQEGNITKVLKGERIGTVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRJ4</accession>
    <name>A0A1U9NRJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="7" type="ORF">STSP2_03446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03446"/>
    <dbReference type="EnsemblBacteria" id="AQT70240">
        <property type="protein sequence ID" value="AQT70240"/>
        <property type="gene ID" value="STSP2_03446"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03446"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="54"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46695" checksum="511014401B352A39" modified="2017-06-07" version="1">MYTGNNILIKNGRLIDPANNVDQICDLFIKDGYVSEIGQLDNDCDHVIDATGKIISPGLIDVHVHFREPGDEEEETIASGSMAAVAGGFTSVVCMPNTKPAVDDATSIEFVHRMARQARKTFVYVMGAITQGRKGTDLAEMGLMQKAGAVGFTDDGAGIQDASIMTRALKYASMLDTVVSQHCQDLSLGSSGVMNSGYNSTVLGLPGMDPLAEEMMLWRDIQLVKRIGVRYHAQHISTAGSVKIIREAKQQGVPVTCEVSPHHLLLTDDCIYEYDTNYKVNPPLRTKADIAALREAIKEGVIDCLATDHAPHLKSEKELEFLAAPFGIASLECALSLYVKALIEPGIIDWPQLLALMTHKPASIIRIEKGTLAKGSIGDVTIIDPDAEYTINAEKFYSKSRNCPYHNWNVRAKVERTIVAGEVRYSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRQ6</accession>
    <name>A0A1U9NRQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">murC</name>
        <name evidence="15" type="ORF">STSP2_03411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03411"/>
    <dbReference type="EnsemblBacteria" id="AQT70206">
        <property type="protein sequence ID" value="AQT70206"/>
        <property type="gene ID" value="STSP2_03411"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03411"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="111"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="316"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="467" mass="50669" checksum="E301458BCCCB1E97" modified="2017-06-07" version="1">MTHTSGRNYHFIGAGGIGMSGLAKVLLKQGAAVTGSDQEDTPVTQSLREAGAKIHGGHACENIQLPCDVVISAAIGPGNPELQVARSNGCKVYKYAQMLGELMDQMRGVAIAGTHGKSTTSGWLTWVMQKGGFSPNYIVGADIPQLGTSSGVGDVENGVFIAEACEYDRSFLNLHPQIGVVLNIEQDHLDYYSDVDDIIDAFSDFCGGVKAGGLVIANGDDENTLKMLGKLDPAVGVVKFGLSEACDVRAENIQLENGRYSFEIVQSCENVGQVSLAMPGRHNVMNALAVYAIAVNAGMQPGEVLEHLGDFQGMDRRLMVKYGGNGVTVMDDYAHHPTEIRASLQAMKQGYEPGRVICIFQPHQYSRTRFLLDDFAESFKLADITVVPDIYFVRDTEESRRLVNAQVLVDRIRSSGCDAYFIETFDEIVDYLKSTARDGDLIVTMGAGDIWKVADEYIQWLAGNSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRV4</accession>
    <name>A0A1U9NRV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbamoyl phosphate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03536"/>
    <dbReference type="EnsemblBacteria" id="AQT70330">
        <property type="protein sequence ID" value="AQT70330"/>
        <property type="gene ID" value="STSP2_03536"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03536"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="125"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36743" checksum="61C96550B5E62424" modified="2017-06-07" version="1">MAESGIYPILFTCVGRRVSLIERFRACVQELGQEPCIIGADMTQMSPALQMCDKKFLVSRVDESPYLEELLKIVRDNGVRLLVPTVDLDLRLLAENRDLFAKAGCFVLISKPEVIDICQDKQKTYRFLHENGIDTPMTWSSEEALEDDNGLAFPCFLKPRDGYASRGSGKVNSRLELEAFTHRIPNCIVQEYIRGNEFTCDVYMDMKGKARCVVPRMRIEVRSGEVSKGKVVKDRHIMDTAANVVEKLGAGPGVITLQLIRSFEGRIAVIEVNPRFGGGVPLAIKAGADFPMWILKELRGEEPEIEFGGFKDGLVMLRYDAEVWLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG69</accession>
    <name>A0A1U9NG69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66923">
        <property type="protein sequence ID" value="AQT66923"/>
        <property type="gene ID" value="STSP2_00061"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00061"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT66923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="393" mass="44669" checksum="D0F7E8D989193CE2" modified="2017-06-07" version="1">MYIDSITTFLPVLAAKGLTPSQRWDAMRDLDSGMPDFLLDGRFIAAGIIAVAMLLLIWYLYRRHLHDREAKLKRKKFYEVSVKHGLDHEQRTILALIARYAELNDPNKIFESNDIYDLGAAKLMKQKLTQGRSVPERQYFNAQITKIKQLLGLKDYTDTEDTRLSAQTSRKIPVGKYLLLTKVDSEQACPMTAEVIENTNYEFKLKTDETVDSNPGQEWRVHYQLGAMIWNFETVELNSQGKVLTLSHSDKVNFINRRKFAHAEVDLNAYIASFPQTFESSDKSSICPQFVKARVIELSGPGLLMRTSLKAKVGHQVLVTLELEHEQVVQSTAKVRRLETNDNETLLGIEMTALSESSINELIAVTNHAIAQRAKHEKQEQQELVESGVNADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG70</accession>
    <name>A0A1U9NG70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">zraR_1</name>
        <name evidence="9" type="ORF">STSP2_00067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00067"/>
    <dbReference type="EnsemblBacteria" id="AQT66929">
        <property type="protein sequence ID" value="AQT66929"/>
        <property type="gene ID" value="STSP2_00067"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00067"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT66929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51235" checksum="69D85CA76964A841" modified="2017-06-07" version="1" precursor="true">MQRIKPSKHVLIIDSDVSPVLLQACAAQGVRTVVASSGKDAFKKLGNNEFDLAIVTNSPATGFDLETCKELKSSAKEENPELPVIMLSEEDSSRAGISAIREDFADFFTKPLSKDQACKLVETWLPNHNTHVMAALGNVGRSLMVGKSQALSKTIHMARRVAGTNAPVLICGESGTGKELLAQYIHDQSQRNNGPFVKVNCASLSESLLESELFGHEKGSFTGAQSTRKGRFERANGGTLLLDEITETPPAFQAQLLRVLEEQRLERVGSENDINVNVRVISTTNRDIAEEVRRGNFRADLYYRLSGVRIVVPALRERKEDLEELIWHFINELASETGRKIGKLDAVLVDVFQRYGWPGNVRQLRNVIRTCLILGTGETLQLADVSWLFEELNTDHEAQINGLADMIGTKSLAEIEQQAILATLDQTQGNRTKAAEVLGISDRTIREKIKRYRNRDLLQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGQ2</accession>
    <name>A0A1U9NGQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66928">
        <property type="protein sequence ID" value="AQT66928"/>
        <property type="gene ID" value="STSP2_00066"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00066"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="343" mass="38851" checksum="A77CEAF0526B9521" modified="2017-06-07" version="1">MLVFTIPRTTDMKRILYISILTLLFANGLCKAEDPNSIETLNRYLSEILKVADGDDVQDADEAEKSADNAKADTTEKPQKAETPVIDNKTVSDPNVPAENNETEEQQKTTESKTANSDPNLVPAVTEKDTKQSTSELIKQVRKETYTPIEMKSPVKFKSDSGEMDELLAELRSLRFVKVRETSSTNSSLPASEPEISEENSEKPQTQSEIPQENADDEATVKETSLKELIKNNPTRVVDHFALAEALFSAGEKELAAKYYRQALDKYGKNYSKTDPERAWILFQLGNCLYETKPEEAEIIYEQLMREQPNSEWTKCATVKRQVLRWLMNEKPMELIESNPTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGR5</accession>
    <name>A0A1U9NGR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA_2</name>
        <name evidence="1" type="ORF">STSP2_00272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67131">
        <property type="protein sequence ID" value="AQT67131"/>
        <property type="gene ID" value="STSP2_00272"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00272"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="40602" checksum="DCE7EB0DF97B221E" modified="2017-06-07" version="1">MQQSQRSFAADYDALGRRIRRIKHDIGETRLYFYNDNWQVLEEYEVGMHGTYMAKQYVYGNYIDEALKMSDDTDSHYYIQDHLYSPVALLDTNGSTVERYEYNAYGQATVYTDKGTDNTWLTPDDNTSTTSSPIIANEYTFTGRRLDSLHANQLPLMQYRHRYYDPQMGRFLTRDPAKYINGLNLYQYCQSRPLVYVDPAGLFIDDVVGGIIDGGSEIIGGIGKGVVDIGGGVIGGVVDIGGSLIEIAPGVIGKVWNSPNTAIGLGFGFIGVGFGGEWPHFGHNGINFTYSPWTEEATAITFGNSMIYGEGCGKQGEEGGTNFRPLPWLPTYGNHEEQHTYQGEILGPFYLPAHAIDWIINGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGS0</accession>
    <name>A0A1U9NGS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67132">
        <property type="protein sequence ID" value="AQT67132"/>
        <property type="gene ID" value="STSP2_00273"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00273"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="110" mass="12429" checksum="9050D1F2A631C18E" modified="2017-06-07" version="1">MQEYVDSNVMKMKQLYAYGNYIDEVLAAGGTSSVYYLQDHLYSPVALLDTNGSTVERYEYNAYGQATVYTDKGTDGTWLTADDTTSTTSALDNEFKNTFTDRRLDSLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGW8</accession>
    <name>A0A1U9NGW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-damage-inducible protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00324"/>
    <dbReference type="EnsemblBacteria" id="AQT67181">
        <property type="protein sequence ID" value="AQT67181"/>
        <property type="gene ID" value="STSP2_00324"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00324"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="3">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="287" mass="33005" checksum="A73ED6B582F77E37" modified="2017-06-07" version="1">MDHNGISRMRDQFDSLARNIPEKDVEFWFARDLQEPLGYARWENFIKAIKRAIESCDTAGYFVPDHFRAVTKMVSLGSGAKREIDDFMLTRYACYLVAQNGDPRKEPIAFAQSYFALQTRKQELIEERMNLQARIEARDRLRDAEKTLSKNIYERGVDERGFARIRSKGDSALFGGNSTKMMKTRFGITQNRPLADFLPTLTIAAKNLATEMTNHNVEQDDLAGESLITREHVQNNRSVRNMLKNRGIKPEDLPAEEDIKKLERRVKSDEKKLADRSGALPDDIEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH42</accession>
    <name>A0A1U9NH42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67252">
        <property type="protein sequence ID" value="AQT67252"/>
        <property type="gene ID" value="STSP2_00395"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00395"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4134" checksum="0A69ED74C59F0D90" modified="2017-06-07" version="1">MGEEVGPIEEVSDLHEAESMVAMYDELIEKVRRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH64</accession>
    <name>A0A1U9NH64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin A1 protease</fullName>
            <ecNumber evidence="3">3.4.24.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iga_1</name>
        <name evidence="3" type="ORF">STSP2_00416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.13" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00416"/>
    <dbReference type="EnsemblBacteria" id="AQT67273">
        <property type="protein sequence ID" value="AQT67273"/>
        <property type="gene ID" value="STSP2_00416"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00416"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013228231" evidence="1">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="637" mass="69659" checksum="6EDF29B3533D68B2" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH92</accession>
    <name>A0A1U9NH92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67114">
        <property type="protein sequence ID" value="AQT67114"/>
        <property type="gene ID" value="STSP2_00255"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00255"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13298" checksum="DD3EF0FBCD53455F" modified="2017-06-07" version="1">MDKITFDSRFTCHLMRVDVGAWQRDYAERKAAGLNGSAVQHLGRRRRDIGVVVKLKEPSRAKLKNSLGILRAMDDGGVHEIAIQGGTVYEDVLLEDFKVGDPVVGGSGVSCQVEISFVQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH95</accession>
    <name>A0A1U9NH95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioester hydrolase YbgC</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybgC</name>
        <name evidence="3" type="ORF">STSP2_00269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00269"/>
    <dbReference type="EnsemblBacteria" id="AQT67128">
        <property type="protein sequence ID" value="AQT67128"/>
        <property type="gene ID" value="STSP2_00269"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00269"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="141" mass="16086" checksum="E5219B2408D69EF9" modified="2017-06-07" version="1">MSTEHFPQNVTVDSNTTQIVPRYVETDQGGVVHHTVYPIYFEVGRTELLRDNGLAYSELEKAGVFFVVSDMTVKYRRPAFYDEKLLLITTCTKTTNARVEHHYELKRAETGVTLAEGTTTLACIDKQGKVCRMPEFMFPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHE0</accession>
    <name>A0A1U9NHE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">ligA</name>
        <name evidence="12" type="ORF">STSP2_00368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00368"/>
    <dbReference type="EnsemblBacteria" id="AQT67225">
        <property type="protein sequence ID" value="AQT67225"/>
        <property type="gene ID" value="STSP2_00368"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00368"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="602"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AQT67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="683" mass="76834" checksum="B20008CF54870AEB" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG6</accession>
    <name>A0A1U9NHG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67372">
        <property type="protein sequence ID" value="AQT67372"/>
        <property type="gene ID" value="STSP2_00516"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00516"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14553" checksum="E8A07A91F1EA0BD6" modified="2017-06-07" version="1">MAVDRVRVAVWSVAGIVVLYFIAGSSCWCYVFSPTPRDFAERIVCGSNQKGIHAAVVEYRDEHGELPGSAEVLVEEGYFGEDVLVCPTSGQGYEYERDSFGESDEVLIFCDTDHGGEKVQTMGDGEVVMEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHW0</accession>
    <name>A0A1U9NHW0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome_P460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67513">
        <property type="protein sequence ID" value="AQT67513"/>
        <property type="gene ID" value="STSP2_00661"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00661"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346504" description="Cytochrome_P460 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_P460" evidence="3">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="230" mass="26085" checksum="1E09DBC6BB05F942" modified="2017-06-07" version="1" precursor="true">MNMHTKLTTMLITILITLLITAGCEQRPEDAGAEETQTPTQRQVEPEDQQQKDWQQQQDDMQKQQRDQQQQSDNPNSADAEYAEQLWTKIKDYENWTVPENFKGWQDGVSPHGKILKYYINDAAAEDLTQDGAIIVKENYSEKSEDALMAITIMEKRQGYDPETGDWFYVKYDPAGKVMTNPAGKKLAGLIGKGKSQGCIPCHAAAKGNDYLFMNDEKARTDRNDPNTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB0</accession>
    <name>A0A1U9NIB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">hisG</name>
        <name evidence="14" type="ORF">STSP2_00811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00811"/>
    <dbReference type="EnsemblBacteria" id="AQT67663">
        <property type="protein sequence ID" value="AQT67663"/>
        <property type="gene ID" value="STSP2_00811"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00811"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="52"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT67663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32460" checksum="1AFA421C3BAE260F" modified="2017-06-07" version="1">MSDKVLKLGIPKGSLQKATFNLFEKAGFSISGYERSYFPKIDDPEIELILLRAQEMSRYVEDGVIDAGFTGYDWIMENGSDVHEICELRYSKATSRPTRWVLAVPEEGDIDKPEDLQGGIIATELVSATKKYFADKNIDVKVEFSWGATEVKARLVNAIVELTETGGSLRANNLKIIDTLLTSTTRFICNNQAWQDDFKKHKIENISILLNAAIDAKTKVGLKMNAAKSDLDNLLEILPSEKSPTVSTLADEQYVAIETIVDVKVERDLVPQLKRAGASDIFTYPLNKVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NII5</accession>
    <name>A0A1U9NII5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">menA</name>
        <name evidence="7" type="ORF">STSP2_00880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00880"/>
    <dbReference type="EnsemblBacteria" id="AQT67731">
        <property type="protein sequence ID" value="AQT67731"/>
        <property type="gene ID" value="STSP2_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00880"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31537" checksum="359E5805818DFF9F" modified="2017-06-07" version="1" precursor="true">MRDWLQAVRVFSLTASVVPVLLGAVLAKTSQAGIAWWMLPLVLLAAMFFQAGTNMVSDYYDYKKGVDTDYTFGGSKVIVQRKLSAKSVLTAGLAMFAAGCAIGLVFVWFRGPVILAIGVIGFLGGLLYSAGPVGYKYLALGDLAVFILMGPLMVIGSYFVLTGGYSHPVLLNSLPIGCLVTAILAANNLRDIKHDRQAGVRTFANTAGPQAARIEYYLLIALAYAVVVINILLDILTAWALLVLVTLPIAVNNIRRIKTGDIEDPATLADADVISAKLHLAFGIVLIGSVILGHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIQ0</accession>
    <name>A0A1U9NIQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00752"/>
    <dbReference type="EnsemblBacteria" id="AQT67604">
        <property type="protein sequence ID" value="AQT67604"/>
        <property type="gene ID" value="STSP2_00752"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00752"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="104"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26708" checksum="26B0FFC661C22276" modified="2017-06-07" version="1">MIDLRGYFDKYGSEIMIFAAMVICAGGLWGFIEVVDEVYESDTQPMEEKILQTFRDPEDPAAMRGPDWLRKTVQSISATGNSTVLILVVLVTCGYLFISGNHKAMWTVLITVCGGAFLVFALKGLFDRPRPDIVPHLAEVTTASFPSGHAAISTIVYATLGAVVCRVLPTHTLRIYTIAVAATMAFLIGCSRVLVGVHYPTDVLGGWMLGLAWAAACWLVVLYLQRRGMVESEDDSEGKKVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIR8</accession>
    <name>A0A1U9NIR8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">STSP2_00786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00786"/>
    <dbReference type="EnsemblBacteria" id="AQT67638">
        <property type="protein sequence ID" value="AQT67638"/>
        <property type="gene ID" value="STSP2_00786"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00786"/>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25078" checksum="E8FE5729AA54E086" modified="2017-06-07" version="1">MARKRLPEVGSFEVSPSILSGDFSNLQSEIKEVEAAGLNMLHLDVMDGHFVPNLTFGPPVVAKMRKHTDMVFDTHLMITNPEKYAKPFVDAGSDHITFHVEVVDDPAEFIKYLHGLGATCGVTLNPETPVETVEKVAPLCDMVLVMTVHPGFSGQEYIAAAAKKIVTIREIVGPNIRIEVDGGISPETVPEVVGFGADTFVAGSAVFGKSNRAKAIRYMLDAAEEAKSRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ33</accession>
    <name>A0A1U9NJ33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-alanine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dat_1</name>
        <name evidence="6" type="ORF">STSP2_00897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00897"/>
    <dbReference type="EnsemblBacteria" id="AQT67748">
        <property type="protein sequence ID" value="AQT67748"/>
        <property type="gene ID" value="STSP2_00897"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00897"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047810">
        <property type="term" value="F:D-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30813" checksum="6D45A0D4F43AFA67" modified="2017-06-07" version="1">MEKVFLNNKLVDACDAKVSISDSGFLYGMGLFETMRAVEGKVFALDDHLDRLFASAEKLSIFNPHSREFIGDAIGQVLEANELEDARIRLTLTSGPMNVGADEEPEPTLVITATDFAPYPAEFYDKGVKVIISDYRQNPLDPATGHKTINFFSRLMVLKDAHKKQAAEAVWFTNDNLVAEGCVSNVFIVKDGKVFTPKTSTPVMPGIARKHVLGLAKAEGIDAQEKDLTINDLLGADEIFVTNVIMKVLPVIAVEAHDVGEGKPGEVTKTLLDMFNKQLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ34</accession>
    <name>A0A1U9NJ34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01091"/>
    <dbReference type="EnsemblBacteria" id="AQT67939">
        <property type="protein sequence ID" value="AQT67939"/>
        <property type="gene ID" value="STSP2_01091"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01091"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011231">
        <property type="entry name" value="Phage_VT1-Sakai_H0018"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09956">
        <property type="entry name" value="DUF2190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030771">
        <property type="entry name" value="UCP030771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="112" mass="11389" checksum="BBF558B9CFB296D5" modified="2017-06-07" version="1">MTAVYKQRGDAIDYTPDVDVTAGDVVVQGDLVGIAKLDIAAGELGALAVVGVFDVPKATGVGEAIAAGAKLYWDEVDSQATTSDGSGANKYMGKCILAAGDDDTAVRLRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE3</accession>
    <name>A0A1U9NJE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68053">
        <property type="protein sequence ID" value="AQT68053"/>
        <property type="gene ID" value="STSP2_01208"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01208"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="37" mass="3948" checksum="E192324989145318" modified="2017-06-07" version="1">MCVYNNKGKKVWTVCPVRSGLGSGTKVVTLGDVTCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE9</accession>
    <name>A0A1U9NJE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01079"/>
    <dbReference type="EnsemblBacteria" id="AQT67927">
        <property type="protein sequence ID" value="AQT67927"/>
        <property type="gene ID" value="STSP2_01079"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01079"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="758" mass="83727" checksum="790EE4AF7A36BFD4" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJG2</accession>
    <name>A0A1U9NJG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_01228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01228"/>
    <dbReference type="EnsemblBacteria" id="AQT68073">
        <property type="protein sequence ID" value="AQT68073"/>
        <property type="gene ID" value="STSP2_01228"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01228"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301699" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="342"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="529" mass="58041" checksum="A63165E971E7E8FC" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS8</accession>
    <name>A0A1U9NJS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ_2</name>
        <name evidence="10" type="ORF">STSP2_01152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67998">
        <property type="protein sequence ID" value="AQT67998"/>
        <property type="gene ID" value="STSP2_01152"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01152"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364397" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="777"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120800" checksum="9C8C323201C61ADF" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJV3</accession>
    <name>A0A1U9NJV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00935"/>
    <dbReference type="EnsemblBacteria" id="AQT67786">
        <property type="protein sequence ID" value="AQT67786"/>
        <property type="gene ID" value="STSP2_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00935"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22827" checksum="6A42A114266307BD" modified="2017-06-07" version="1">MDANTNKVMIDRDDVVMLLIDHQAGLFNLVKDMPVAQLRNNVIALAKAAALLDIPVITTASVPEGPNGPMIPEIHHYAKHAKYVAREGQINAWDVPGFVKAVEDTGRKTLVMTGTLTSVCLAFPAVSATAAGYKVYGVVDASGNWSRMATDLAIARMAHAGVVPVDTFAIITELQQTWNRPDAMEYAGIYGEHVIPNYQLLMESYTSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX0</accession>
    <name>A0A1U9NJX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">csrA</name>
        <name evidence="3" type="ORF">STSP2_01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01270"/>
    <dbReference type="EnsemblBacteria" id="AQT68115">
        <property type="protein sequence ID" value="AQT68115"/>
        <property type="gene ID" value="STSP2_01270"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01270"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7448" checksum="CAE910A9B3112EE8" modified="2017-06-07" version="1">MLVLSRQKDESIIIGDDVEVTIVDVRGDKVRLGITAPRSISVHRKEVYEAIQKEKQQKVKGASTNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJX4</accession>
    <name>A0A1U9NJX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoxic response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrp1_2</name>
        <name evidence="3" type="ORF">STSP2_01378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01378"/>
    <dbReference type="EnsemblBacteria" id="AQT68222">
        <property type="protein sequence ID" value="AQT68222"/>
        <property type="gene ID" value="STSP2_01378"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01378"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15512" checksum="149889A3B85AAAB7" modified="2017-06-07" version="1">MQVKDIMTQALDKIESTASLTEAAKHMSYRDVGILPVSKADQIVGVITDRDIVIRGLAQDKQPGQTTVSEVMTTNLIFCSEGDDIHEAGKLMEEKQVRRLLVSDQNDKLVGVLSLGDLAAKCGEDIFSGEVLEAISEPATPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK15</accession>
    <name>A0A1U9NK15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xerD_1</name>
        <name evidence="7" type="ORF">STSP2_01405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01405"/>
    <dbReference type="EnsemblBacteria" id="AQT68249">
        <property type="protein sequence ID" value="AQT68249"/>
        <property type="gene ID" value="STSP2_01405"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01405"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="315" mass="36291" checksum="FFEEA47F93DACFD3" modified="2017-06-07" version="1">MSNSRKEKRMINHIILHSTDSTPEDSRTPQSLRPNAISKQAENDQELVKLWLYGKSKHTQRYYRKDVERFFEYTNKSLREIILKDLQEFANHIDEQDLVDGSKRRILSSVKSFFAFAHKLGYLTFDVARVLALPTPKDTLAERILTQEQVRKIINAENHPRNKLILKTLFITGIRVSELCSLCWKDLKERSEGGQVTVYGKGKKTRTLLIPEPLWSELMNFRGSAFEDVFVFRGRNRSTQMHSTTVLRIVKKAAQKAGLKVTPSPHWLRHAHSSIACEKAPLHVVQNSLGHSSIQTTSHYLHVKPDDCSSKYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK17</accession>
    <name>A0A1U9NK17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68271">
        <property type="protein sequence ID" value="AQT68271"/>
        <property type="gene ID" value="STSP2_01429"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01429"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012211449" evidence="1">
        <location>
            <begin position="33"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="494" mass="55192" checksum="8F7C6C6DB800A5F8" modified="2017-06-07" version="1" precursor="true">MSVKFLSGSKCVFMLFLAALSLFALPVSLSQAAEPAEEAPRVHAVVDIGHQFSFYGDGRFHTQYLPGQPRATCWGALYNFDYSNANLLVLLGCESKLKYLPKDFRTMVQFMRDGGGVVLLGWASSKPQNELAQKFGVTFKKGAKKPFKAVSDEITDEIEGRGDWFEIRNPAIWEVLIADAQGRAVLARRNVGKGTLLVGARGLAGSRPDAKDNINASWWTPLLEKTSAGKPVDPKKPFRSIGLGNLEYTEKLGNIKLHYSEYLRPYAKAMADIYQRVNPQIEERMGVPLSDGMASEIGLLATGGGGFSSGRMLGLAVFWGGFPDREDSMIEFITHESVHSWVLPFPEIWNEPIATYVGDLVMVDMGYPEEGMRRINRTIDRAKKIDPTMKKYDIRGKSITGEDLEGGQANAMHWGKTFWIFEQMRKENPDVVADYFKAKRELAKPGEIEKYDANNTVAIMSVAMGRDMFGWFHEHGFDVSRDKSEIKIELESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK42</accession>
    <name>A0A1U9NK42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4-mannooligosaccharide phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01263"/>
    <dbReference type="EnsemblBacteria" id="AQT68108">
        <property type="protein sequence ID" value="AQT68108"/>
        <property type="gene ID" value="STSP2_01263"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01263"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="37491" checksum="3DBF83777B8FE810" modified="2017-06-07" version="1">MAASSKIIGSSLPNIPWQDRKPGSSEIMWRHSGNPVISRDHIPSSNSIFNSAVVPYKDGFAGVFRCDNKNRQAWIHSGQSTDGINFEIDHEPIDFECAEPDIAERVEWYDPRVLWLEDRYYVTWCNFYHGPTIGVGYTYDFKKFYQMENAFLPYNRNGVFFPRKINGRYAMLSRPSDAGHTAYGDIFYSESPDMCYWGKHRFVMGTTIGWQSKKIGPGPVPIETTEGWLMFYHGVLYSCNGFVYSMGAALLDIDKPWKVVARTKPYLLSPQELYECVGDVPNVVFPCAALTDADTGRIAVYYGCADTVTGLAFCKVDEIIDYIKGSSNNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK87</accession>
    <name>A0A1U9NK87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple antibiotic resistance protein MarA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">marA</name>
        <name evidence="2" type="ORF">STSP2_01313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68158">
        <property type="protein sequence ID" value="AQT68158"/>
        <property type="gene ID" value="STSP2_01313"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01313"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="32712" checksum="CB16B0D633197100" modified="2017-06-07" version="1">MNIWNVKFQVIQPLASFPRPLCIEREVHSSPSYYNEGPFRQGEKHCFIKYTLSGRGELRDSSGTYSLTPGTCFLCDVRAPEFEYYYPENAAEPWEFFWMGFIGDTATKMVRELIARNGNIYNLPPDTTIIRKLLKYKNYNGLTCDLTPFDALKLVTEVISALTASCWSQHPDDARSILVRRTQQMITDNITGPVRISEIAHQLTVSREHLSRVFKEHIGMTLQEYILRQKMILACKLLRETTLSNKQIAARLGYDRPTHFTRAFKSLLHVTPSQFKEMGMTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK88</accession>
    <name>A0A1U9NK88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68235">
        <property type="protein sequence ID" value="AQT68235"/>
        <property type="gene ID" value="STSP2_01391"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21821" checksum="08EE2E9E99FE0125" modified="2017-06-07" version="1">MQPLFTVHAGEYLVGSYIEKHFKKYNVWVPSKDTGIDLLVTDSKNRMTATIQVKYSKDYTTTHMKPGHNNGFRSWGWWTLNPSKIRSSKADLWVFVMQSFAHKSIECVVIPPKELMSVLKKVHGHGKKKYQSYMWVRNDDTCWETRGLIRAEKYSLAHVDHEDENRNLTDYLNNWKPLKQKLARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKA9</accession>
    <name>A0A1U9NKA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68255">
        <property type="protein sequence ID" value="AQT68255"/>
        <property type="gene ID" value="STSP2_01411"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01411"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="14048" checksum="C3D31A5D481FF85D" modified="2017-06-07" version="1">MSTAVGLLQITRSTYNDYYDRGIFPQNDLWKTNFGEVWDESNLVNPARNMVAGLFVLQGKPGTTLQEKLGNYYGKGNNSNRAYSGKILKGARFVKDFLERKDLRHLSPQECSTLMRELDDIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKE7</accession>
    <name>A0A1U9NKE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_14</name>
        <name evidence="5" type="ORF">STSP2_01551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01551"/>
    <dbReference type="EnsemblBacteria" id="AQT68391">
        <property type="protein sequence ID" value="AQT68391"/>
        <property type="gene ID" value="STSP2_01551"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01551"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="555" mass="62493" checksum="45C57698A7C14059" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKJ5</accession>
    <name>A0A1U9NKJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68258">
        <property type="protein sequence ID" value="AQT68258"/>
        <property type="gene ID" value="STSP2_01414"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01414"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4353" checksum="8AFA9417E34BCA5F" modified="2017-06-07" version="1">MPHRNAMVVYLILFNYGLMNTVKLMNSDIWDSLLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL3</accession>
    <name>A0A1U9NKL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-iminoacetate synthase</fullName>
            <ecNumber evidence="8">4.1.99.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiH_2</name>
        <name evidence="8" type="ORF">STSP2_01436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.99.19" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01436"/>
    <dbReference type="EnsemblBacteria" id="AQT68278">
        <property type="protein sequence ID" value="AQT68278"/>
        <property type="gene ID" value="STSP2_01436"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01436"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036355">
        <property type="term" value="F:2-iminoacetate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024007">
        <property type="entry name" value="FeFe-hyd_mat_HydG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF2">
        <property type="entry name" value="PTHR43583:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00319">
        <property type="entry name" value="Fe_hydrogenase_maturase_(HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03955">
        <property type="entry name" value="rSAM_HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="71"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51932" checksum="00C6A32A6C8800F9" modified="2017-06-07" version="1">MKHIDAARIEQLLQKHSKTDNAKVDAVLDKARSLQRLTLEETAVLLAADDAQNTEKIMEAAAYVKDAIYGKRVVLFAPLYISNACVNNCRYCGFKCENRSVDRRSLTPEEIKEQVSWLLNRGHKRILMVAGEALNFDGKKAIDYYCDSVQAIYDAQAGKNRIKRVNVNAAPLSVEEFKQLKGIGIGTYQVFQETYHDETYRYMHPSGPKSDPDNRINAIDRAFAAGIDDVGIGVLYGLYDYKFETLAMLMHCEHLENKFNVGPHTISVPRIEPVAGSDVSENVPHPLTDEDFMRLVAILRLSVPYTGIILSTRETPEMRDILVHHGVSQISAESRVSPGGYDDEETEEGIQFTLGDHRTQDEIIGSLLEQGYLPSFCAACYRKERTGERFMSLAKPGAIKGMCQVNALVTLKEYLDDFASDSVKQAGYKLINKQINSLTGTDREILRDMFKHIDDGVRDEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKW9</accession>
    <name>A0A1U9NKW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01749"/>
    <dbReference type="EnsemblBacteria" id="AQT68581">
        <property type="protein sequence ID" value="AQT68581"/>
        <property type="gene ID" value="STSP2_01749"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01749"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30982" checksum="6765B4F4C444D66B" modified="2017-06-07" version="1">MNDLSEHRDNALQNKGRTCPCCGAKLHPAFYFCIVCATPYKPVEAITGKFSNFEAVTDPDLIKTRAPNVWPVFWSYTVVLFILLILGILMDAGDSAFAYMLVLGSILMSGVTIFFSCRFWPSLVVQFKRLGLFTPAMALSVTALFGLLTINYIYHYILLQTFTEFKHIPTHFEEAGLGALSLLFFICIIPAIVEEIAFRGLIQHWLVRAITPLKAMLLASALFTALHLTVLSAPYLFAVGMLLAWVKYKTGSLYPPMILHFVHNAVAVFIFPLIANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX9</accession>
    <name>A0A1U9NKX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01759"/>
    <dbReference type="EnsemblBacteria" id="AQT68591">
        <property type="protein sequence ID" value="AQT68591"/>
        <property type="gene ID" value="STSP2_01759"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01759"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="404" mass="46882" checksum="4723E2AAE113600E" modified="2017-06-07" version="1">MASVCFYFQVHQPFRLRHYTIFEQNDSYFDEYKNAAICRKVANKCYLPANRLLLKLIRKHQGRFKVAFSITGVALEQFEKYCPEVMSTFDALARTGCVEFLAETYYHSLSFLYSRNEFAEQVKKHSDTIESLFGQRPRIFRNTELIYNDELAKEIESMGCFDAVLTEGADHILGDRTPDFVYKPAGCENLKLLLKNYSLSDDIAFRFSNKQWPEYPLYAGKFANWVNAVNGNGNIINLFMDYETFGEHQWADTGIFDFMAHLPEQIMQHPDNDFKTPSEVVDSYHDMGEVSVPHVISWADEARDLSAWLGNAMQSNALHEAYRLENLVKLTGDKELLEDWRKLQTSDHFYYMCTKYFNDGDVHKYFSPYDSPYDSYINFMNVLHSLKARCETGDDADKKTAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL16</accession>
    <name>A0A1U9NL16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase class I, anaerobic</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fumB</name>
        <name evidence="4" type="ORF">STSP2_01680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01680"/>
    <dbReference type="EnsemblBacteria" id="AQT68515">
        <property type="protein sequence ID" value="AQT68515"/>
        <property type="gene ID" value="STSP2_01680"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01680"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19032" checksum="8C812FE3D1D6872D" modified="2017-06-07" version="1">METVVKIYTPLDEDVTRELKAGQEVAISGVVYTARDQAHKRLCELLDKGEELPFEVDGAVIYFVGPTPAPPGRAVGAAGPTTSSRMDAFSPRLIEAGLRGMIGKGYRGQEVRDACSKYGAVHFATIGGAGALLSKHIVKSEIVAYEDLGTEAIRRLEVVDFPAVVAYDSRGQSVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL22</accession>
    <name>A0A1U9NL22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">STSP2_01584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68424">
        <property type="protein sequence ID" value="AQT68424"/>
        <property type="gene ID" value="STSP2_01584"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01584"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19537" checksum="1F242D907FCDDB23" modified="2017-06-07" version="1" precursor="true">MQMEADEHYIEDGGRLRLEAFEKPKSRKIALRMLPLIDVIFLLLAFFVLTANFRLPEDFMSIKLPKRDARIETYSAIEPLNVQVTNQSNGCRVVIGGRAQADITADDIDTGLAEFANAFRSVADAQGRYAGDPVEIRCDDEVTWEYLVKIYDVLGSMGMDDVTFCMNESWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL91</accession>
    <name>A0A1U9NL91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADP-reducing hydrogenase subunit HndC</fullName>
            <ecNumber evidence="9">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hndD</name>
        <name evidence="9" type="ORF">STSP2_01434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01434"/>
    <dbReference type="EnsemblBacteria" id="AQT68276">
        <property type="protein sequence ID" value="AQT68276"/>
        <property type="gene ID" value="STSP2_01434"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01434"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="590" mass="65733" checksum="3403F4032379F50D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL97</accession>
    <name>A0A1U9NL97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01745"/>
    <dbReference type="EnsemblBacteria" id="AQT68577">
        <property type="protein sequence ID" value="AQT68577"/>
        <property type="gene ID" value="STSP2_01745"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01745"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15557" checksum="9D8F84991AE925A0" modified="2017-06-07" version="1">MTARYEHFQHQADIGVRGIGPTIEEAFEQGAIGLTQVICDYETVEPATAEDIHCQAPDIELLFADWLNQLILQMAVNGMLYRKFEVHIDGSELHAKAWGEKADPEKHDIAVEVKAATYSELKVYRNAQGDWAAQCVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL98</accession>
    <name>A0A1U9NL98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01885"/>
    <dbReference type="EnsemblBacteria" id="AQT68713">
        <property type="protein sequence ID" value="AQT68713"/>
        <property type="gene ID" value="STSP2_01885"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01885"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="576" mass="64998" checksum="5CF92A69C0191720" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLB9</accession>
    <name>A0A1U9NLB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68709">
        <property type="protein sequence ID" value="AQT68709"/>
        <property type="gene ID" value="STSP2_01881"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01881"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6777" checksum="9915F5D39EF6DC5D" modified="2017-06-07" version="1">MPRETSFAAKLCKFVLTLAKLPIWVAAVFTSLLICWLIGLTFYRAAIWIYNHYLSQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD0</accession>
    <name>A0A1U9NLD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68743">
        <property type="protein sequence ID" value="AQT68743"/>
        <property type="gene ID" value="STSP2_01915"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01915"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="3">
        <location>
            <begin position="455"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="562" mass="60808" checksum="84ADC0E1F2DBB227" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG3</accession>
    <name>A0A1U9NLG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">apu_7</name>
        <name evidence="3" type="ORF">STSP2_01921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68749">
        <property type="protein sequence ID" value="AQT68749"/>
        <property type="gene ID" value="STSP2_01921"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01921"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301700" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="891"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1038" mass="111176" checksum="0CC460260A4A3777" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLH9</accession>
    <name>A0A1U9NLH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68594">
        <property type="protein sequence ID" value="AQT68594"/>
        <property type="gene ID" value="STSP2_01762"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01762"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12000" checksum="4C3647AEC7FA904E" modified="2017-06-07" version="1" precursor="true">MAKKKAKKKKTTKKAAKKKTTKKKATKKKKTTKKKATKKKGTKKKAKKAAQKEMLVVTSKVKAYIKSKGLMTSSDAVEAINDKIYAMIDDAAARTESNRRSTVKPQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI5</accession>
    <name>A0A1U9NLI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional oligoribonuclease and PAP phosphatase NrnA</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nrnA</name>
        <name evidence="3" type="ORF">STSP2_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01590"/>
    <dbReference type="EnsemblBacteria" id="AQT68430">
        <property type="protein sequence ID" value="AQT68430"/>
        <property type="gene ID" value="STSP2_01590"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01590"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="244"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36396" checksum="F523942F05878045" modified="2017-06-07" version="1">MATQQDFVNAVELIDKSNNVLVTSHTRPDGDACGCVLAICTALEQLGKKAQPMFLSAIPEWYRFLFESEPAVIGEDITTEELSGAGYDLVVIVDTNSYVQLAKFDEWLRASDVPVLVIDHHVTSDNLGDVEVIDTTASAAGEIVYDLFKRAGWELGGKTARDLFVAIATDTGWFRFRNADARVYRYAAELIERGVDPAAVHEQIYQNFSPARMALLTRMLNNLTLEFDKRVAVQYLLQEDFRAAGASMSDTEDLIDECQRVSTVQVAVIFVELGNGKFKISLRSKTNVNVREIAQLYGGGGHTVAAGATLDMPLEQAREEILGHIAKQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLI6</accession>
    <name>A0A1U9NLI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar kinase YdjH</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydjH_1</name>
        <name evidence="4" type="ORF">STSP2_01516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01516"/>
    <dbReference type="EnsemblBacteria" id="AQT68356">
        <property type="protein sequence ID" value="AQT68356"/>
        <property type="gene ID" value="STSP2_01516"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01516"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="39"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="301" mass="33001" checksum="866063384DA22FB0" modified="2017-06-07" version="1">MSLLVTGSIGIDTVTTPFGVSEGCIGGSAVYFSMAASYFAPVRFLGVIGDDCPFDLRDAFRDKTVDLTGLETRPGSKTFRWKGSYHGDMNEANTEDVKLNVLGERPPLFPDTYRDTKYVFLANTAPSLQMELLENIDHPQFVAADTMNLWIENEREDLLELLDKIDMLILNEGEARLLTGQKNLVTAAQDILKMGPRVSIIKKGEHGSLMVDSNGDCFMLPAYPTTVVIDPTGAGDAFAGALMGYLAKIGKIDVMSIRNAMVYGTVAASFAIGDFSIHGIKAVELSRIEDRFDFLRKVTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLM3</accession>
    <name>A0A1U9NLM3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">serS</name>
        <name evidence="10" type="ORF">STSP2_02009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02009"/>
    <dbReference type="EnsemblBacteria" id="AQT68833">
        <property type="protein sequence ID" value="AQT68833"/>
        <property type="gene ID" value="STSP2_02009"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02009"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="136"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="423" mass="48052" checksum="A2420715AA5F278E" modified="2017-06-07" version="1">MIDIKQIRQEPQKFKQACENKNIAADIDKLLTVDEELLNVKKQLQDIATEKNAVGKSIPKLGPDEKKQAIDRLSELKKEEAGLNDKTKELQPVYDRIMLEVPQPADVGVPLGQDDTENVEMRKWGEIREFDFEPKDHVELGMELGMIDIERGVKLAGTRNYFLTGDGALLHWAILRFSFDHMISKGYRPMSVPLLMRDEAMMSTGYYPGAEEQTYRMEKDELNLAGTAEVPLTAYHSGEILSEEDLPLKFVAQSTCFRREAGAAGKDTRGLYRIHQFDKVEQVIIGVNDVEQSKKFHEEILGNSEAVMQALNLPYRVVNVCTGDLGKGQVQKYDIEAWMPSRESFGETHSASRFYDFQARRMNLRYKADGKKNVFCHTLNNTVIASPRILIPVMELYQNADGSITIPEALRPYMGGKEKIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ3</accession>
    <name>A0A1U9NLQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqgF</name>
        <name evidence="4" type="ORF">STSP2_02039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02039"/>
    <dbReference type="EnsemblBacteria" id="AQT68863">
        <property type="protein sequence ID" value="AQT68863"/>
        <property type="gene ID" value="STSP2_02039"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02039"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15430" checksum="23FC634A210FB7A7" modified="2017-06-07" version="1">MRFLAVDFGEKRTGLAVCDEKETMAFPLTVLEGQGGLANRIAKIAKEEQAQGFVMGLPLNMDGTEGDRAARVRHFTEKLSQVTDLPVFFHDERLSSFEAENKLAGHLTRKKKKKHLDAVAAAGILESFLQKRREMPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLU9</accession>
    <name>A0A1U9NLU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable pectate lyase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01980"/>
    <dbReference type="EnsemblBacteria" id="AQT68805">
        <property type="protein sequence ID" value="AQT68805"/>
        <property type="gene ID" value="STSP2_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01980"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="1615"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="2152"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="2856"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="3176"/>
            <end position="3274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2460"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2471"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2491"/>
            <end position="2515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="3517" mass="377685" checksum="E886531B3E62765C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLX4</accession>
    <name>A0A1U9NLX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic di-GMP phosphodiesterase response regulator RpfG</fullName>
            <ecNumber evidence="2">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpfG</name>
        <name evidence="2" type="ORF">STSP2_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02086"/>
    <dbReference type="EnsemblBacteria" id="AQT68909">
        <property type="protein sequence ID" value="AQT68909"/>
        <property type="gene ID" value="STSP2_02086"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02086"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="331"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="556" mass="62271" checksum="42F5EA3C36DFFE30" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM34</accession>
    <name>A0A1U9NM34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_02043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02043"/>
    <dbReference type="EnsemblBacteria" id="AQT68867">
        <property type="protein sequence ID" value="AQT68867"/>
        <property type="gene ID" value="STSP2_02043"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02043"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT68867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15953" checksum="FA6F8F97CF1C5359" modified="2017-06-07" version="1">MNTYWILAANGAEGEEGQVIQGGQAEEGQTEEMTTEDGSQQTPPADGEGQGDAPGFGFGQLLPLIIIFVVFYFLIIRGPKKRQQQHSKMVSSLKKNDRVRTIGGIYGTVIDIKDNELTIKIDENTNAKIKVSPGAIAEVVSDKSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM59</accession>
    <name>A0A1U9NM59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69032">
        <property type="protein sequence ID" value="AQT69032"/>
        <property type="gene ID" value="STSP2_02212"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02212"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6152" checksum="ACFB964F63046248" modified="2017-06-07" version="1">MHMMVFVLVQRAGFDRLNGEGGIRLRGPGWCQTRVATLRVAACSNPFGNKSIIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM87</accession>
    <name>A0A1U9NM87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid protease GlpG</fullName>
            <ecNumber evidence="7">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glpG_2</name>
        <name evidence="7" type="ORF">STSP2_02202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02202"/>
    <dbReference type="EnsemblBacteria" id="AQT69023">
        <property type="protein sequence ID" value="AQT69023"/>
        <property type="gene ID" value="STSP2_02202"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02202"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="74"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="31867" checksum="D3F761E026E46AD8" modified="2017-06-07" version="1">MGIYDRDYTKNMYSGGGGGGGMRLAMPSLTPIVKWLLMINLGVFLAMFMIPPIANLFVRLFAVWASPWWESLLVWRYISYQFLHGGFLHVLFNMLGLYFFGTMLERTWGSKHFLRFYLTCGAVGGIVYPLMVFANVIQPGFLLGASGSVYGIIAAVAILYPRVRVYIYGIFPVPMWVLGLIILFASIASFQSGDNAGGQVAHLAGLATGAVWVYWKPLQNKARIKKQHGKWTEKIQQERRFQKDVDHILAKVHKHGIKSLSRKEKKILKQATDREQKQNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM90</accession>
    <name>A0A1U9NM90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68927">
        <property type="protein sequence ID" value="AQT68927"/>
        <property type="gene ID" value="STSP2_02104"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02104"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013182902" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30128" checksum="E999040D4DBAEB98" modified="2017-06-07" version="1" precursor="true">MVVAIISLLLSISLPAIGRVRQCAQNLKNISNQRTVLGAANLFTADYDGDYPKSVATIGKDSFWNWNDPRMMKSSDYISGRKHNSISEYLSDYVESSEPFTSPLSPSKHRYMEDAWEQGDSWDNPDTPSDLDLLIGQYCFYWDYEGLVSRAGRRFIGPSRQAGGGGQSDILVSDYLGFGNWRTPDSLASSRSFDDASVCPEDTTCGAYWFKNGAASMDDLDISISAGFTDGHVESFPANEMVPMWVIMIRPDTVYPLGVGPGVFYLPRKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NM98</accession>
    <name>A0A1U9NM98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-alpha-N-acetylgalactosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.97" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02214"/>
    <dbReference type="EnsemblBacteria" id="AQT69033">
        <property type="protein sequence ID" value="AQT69033"/>
        <property type="gene ID" value="STSP2_02214"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02214"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050110">
        <property type="term" value="F:mucinaminylserine mucinaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013341557" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="791"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128256" checksum="23264CB2C86B2273" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMA1</accession>
    <name>A0A1U9NMA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68720">
        <property type="protein sequence ID" value="AQT68720"/>
        <property type="gene ID" value="STSP2_01892"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01892"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="89" mass="10279" checksum="474BE07A41690DCB" modified="2017-06-07" version="1">MVFIKMFHGRKDPAQQMDDWGLDGPVLGPYQNIHVTYTSYIKLIDENGNCDMLRIIEDMIYYAGCYYGDWIISGNPKQNNIEKIDPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMC3</accession>
    <name>A0A1U9NMC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--LPS heptosyltransferase 2</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfaF_2</name>
        <name evidence="2" type="ORF">STSP2_02244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02244"/>
    <dbReference type="EnsemblBacteria" id="AQT69059">
        <property type="protein sequence ID" value="AQT69059"/>
        <property type="gene ID" value="STSP2_02244"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02244"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="37929" checksum="D156E3666DB059D5" modified="2017-06-07" version="1">MVIEENVRTKNQGMTGAIINPGAIGDCILTLPLARFLKERLSLARLDMIANSDYVSFYPKRTCVDVVRSINSIAMHRLFVGPDEFELDQHDQLIRDFSHYDYIVSLLGEPGGSFESNLIFTVYCSRSAEVTTIRMHPAEGQNRHVAVSYIDQYCEANGLQCEGLSAGLNTELITPTADDKQAGRFILQSLGVNPDKPVIGIHPGSGGKYKCWHIDNYLALAEKVRKNGSVPVFIIGPAEKEHLNKAALNRINDEHTVAENYKLLEIMQILSTVQAFVGNDSGIAHLAAGSGLPAITVFGPTDPALYKPAGPHSHAIAVEPVDFDEPNPAAVEDVEHSLNELLAKTGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMG1</accession>
    <name>A0A1U9NMG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68924">
        <property type="protein sequence ID" value="AQT68924"/>
        <property type="gene ID" value="STSP2_02101"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02101"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="62" mass="7156" checksum="6FE866E124718856" modified="2017-06-07" version="1">MVKKVNSRVLRSEPLRRPIVHRAEFGGSSEHRRERGRGKSYGPFKNSHDDPFPCGLFFNIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMH2</accession>
    <name>A0A1U9NMH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68928">
        <property type="protein sequence ID" value="AQT68928"/>
        <property type="gene ID" value="STSP2_02105"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02105"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="88" mass="10038" checksum="D57E7B486847CC07" modified="2017-06-07" version="1">MRAIKNTITAVITTITITSLGPSKTACIDYPLRKIEKGRTRIHKMSGALYHGSIKLSSRPRKLLQQVMWRHDLFYSLARQVKDARPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMI3</accession>
    <name>A0A1U9NMI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCA-adding enzyme</fullName>
            <ecNumber evidence="6">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cca</name>
        <name evidence="6" type="ORF">STSP2_02228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02228"/>
    <dbReference type="EnsemblBacteria" id="AQT69045">
        <property type="protein sequence ID" value="AQT69045"/>
        <property type="gene ID" value="STSP2_02228"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02228"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="411" mass="46468" checksum="3540EFBC63968BC9" modified="2017-06-07" version="1">MNPVNRTMTNKQAATKVVHRLREEGYQALFAGGCVRDMLLGRQAKDYDVVTDARPKQVMDIFRRTLEIGAQFGVVVVMLKKHQVEVATFRTESGYADGRHPQEVHFSNAREDAARRDFTINGMFYDPVAEQVYDYVGGQTDLDRQVIRTIGEPHERFSEDFLRMLRAVRFATQLDFEIDPATWNAVRELAGNITRISGERIGMELEAMLISPNRARGARLLIENELADQIFPEIDPNELTAGIGVLEQLPNGAGYELTLAGLFSACKSAAVINSLAVIRPSNALIKHVQFLLDNRGVLLEDDMRLARLRLLLAEPYFDDLYEYQLAIQKAKGESVKPLETIRSRAQELKGTELTPDPLLDGHELMKLGVKPGPMVGEVAREMYLEQLDNRLRTRQKAEEWVRNRINSDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMJ5</accession>
    <name>A0A1U9NMJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose-resistance amylase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA</name>
        <name evidence="5" type="ORF">STSP2_02316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69129">
        <property type="protein sequence ID" value="AQT69129"/>
        <property type="gene ID" value="STSP2_02316"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02316"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="342" mass="36663" checksum="9FFA7A960BF37162" modified="2017-06-07" version="1">MSNATANLSDVAKRAGVSKSTVSRVLNNKLGNGFSVKEEVRSRVIDAAKQLNYRPNLIAQSLTKSKTRMISILGGSHALSELGNIYQTVVNNATAVLDESGEGFDVTIDMSSHSKTDSELPAWRVDGVIVLASCSETTMQELESSGIPYVVVNGPAGENGASVVPDDVCGMVEAINHLAEFGHKKIAYAGPVGKVLQGHSSLQDRFSTYLSEMSRLGLEPIFGKGDVCASADKFLESVVIARGATAAVAYGHMGGLNLMQAAHAHGISVPERLSLICFCDEYANRIMSPRLTFIDLRTRDMGRIAAELLLEKIKSPKQELNRLVKLEEKLVLRESTAAPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM1</accession>
    <name>A0A1U9NMM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylE_1</name>
        <name evidence="8" type="ORF">STSP2_01928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68756">
        <property type="protein sequence ID" value="AQT68756"/>
        <property type="gene ID" value="STSP2_01928"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01928"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="499" mass="54700" checksum="E7C6DF65D4CB2567" modified="2017-06-07" version="1">MNSINTVSPGNDTSRPGSSFYLFGICFITTLGGFLFGYDTAIISGCNVFLESHFELTKNGLGWAASSALLGAIFGTMFAGYVADRAGRKPALIMASLCLVISATGSMLPPTFLSSPESFPWFSSGRASAFGFLIIARLIGGVGVGITYAISPLYIAEITLPKIRGMMVSVYQLSITMGILLAFLVDFLILRAAGDDAGIISAQASGSFWHWAFKAEIWRGMFGTEIPIALAFFLLLFLAPESPRWLIGQGRKENAMRILTRIGGENQARKEMAELDKVLQQEEGKFTELFHPYLRIPLMIGILLPIFSHLSGIAAIMYYAPNILNESMQSSESSFMGAVLVGLVNMLFTFVAIRKIDKFGRRKLLLTGVLGVFISLACVGILFLLGSKWVIIPLLIYVACFAFSYGPVVWTVIGEIFPTRIRGRAAALGAFSLSVTSFLITQTNPVLFEKISPAGTFFLYAGFTVPAIWFIWKYVPETKGRTLEEIEQTWLSKKTEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMM5</accession>
    <name>A0A1U9NMM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02358"/>
    <dbReference type="EnsemblBacteria" id="AQT69171">
        <property type="protein sequence ID" value="AQT69171"/>
        <property type="gene ID" value="STSP2_02358"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02358"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012527457" evidence="1">
        <location>
            <begin position="24"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="34225" checksum="21C9BEA7F38F2FEE" modified="2017-06-07" version="1" precursor="true">MKRALVLTAVVFGTVFGYSSVFAEDEAKSEAVKQDKELTVDQIVERTNRVSYYQGRDGKARVKMVITDEQDRKRERQLVILRWDAPNPKLSEEEQGKDDSYTGEQKYYVFFTRPADVYKTVFMVWKHLGKDDDRWMYLPALDLVKRISASDKRSSFVGSHFVYEDVSGRNVDLDEHELLRTTDNYYVLRNTPKDKKLVEFAYYDMWIHKDSFVVVKTDYFDEQDKKYRSYQALKVEQIEGFPTVVKSKMSDLRTGGNTVMEYGEVKYNVGIPESIFTERYLRRPPREYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMT2</accession>
    <name>A0A1U9NMT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine/sarcosine N-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_01992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.156" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01992"/>
    <dbReference type="EnsemblBacteria" id="AQT68816">
        <property type="protein sequence ID" value="AQT68816"/>
        <property type="gene ID" value="STSP2_01992"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01992"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052730">
        <property type="term" value="F:sarcosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014369">
        <property type="entry name" value="Gly/Sar_N_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16458">
        <property type="entry name" value="PTHR16458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000385">
        <property type="entry name" value="Gly_N-mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51600">
        <property type="entry name" value="SAM_GNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="6">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000385-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="268" mass="31303" checksum="B8A4522FF4862313" modified="2017-06-07" version="1">MPFIEKQQFGEDPLKVRDTDHYVKEYASTLVEKWDQLISWDRRAESEGNFFVEKLKENGAKYVLDAATGTGFHSVQLIEAGFEVTSADGSPEMLAKAFENGKQRGHVLRTICADWRWLNRDVHGEYDAVICLGNSFTHLFNERDRRKTLAEYYAALKHDGVLIIDQRNYDAILDQDGYSSKHTFYYCGDQVAAEPDHVDEGLARFVYKFPDKSQYHLNMFPLRKNYLRQLMQEVGFQQIDTYSDFQETHKVDDQPDFFIHVAHKEYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMW4</accession>
    <name>A0A1U9NMW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dac</name>
        <name evidence="2" type="ORF">STSP2_02253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02253"/>
    <dbReference type="EnsemblBacteria" id="AQT69068">
        <property type="protein sequence ID" value="AQT69068"/>
        <property type="gene ID" value="STSP2_02253"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02253"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="484" mass="53775" checksum="9B1CE1DE3C8AFC0C" modified="2017-06-07" version="1">MNSAVLHDKKLAMFERIQKEKFSRRAFFVLIFALASATYAGVNSQITQILNRKHCSGVDFAIKIVDADSGGLLYEQNSEEPMTPASNMKLVTTAAALHYLGPEYEFRTRLCMAGSNVVVVGGGDPLLGDRELARSYDKDPDWVVDDMVKRIKERSIESVNDIILDSTFFDDNRVHPKWPVDQLNRSYAAEVSGLSYSNNCVRMTVSRKSSRVYINVDPVSNYLDLINQVKATSSGSSAAGAYRCNIPNKLYVKGRCRTSTGFDVAIERPALFFGAVLKKKLEEAGIDVRGSIYEKYCKRDPEIEIVAEYRTPLLDVLKRCNKDSLNMAAESLVKTISAENTTGKVNGEWEHGLVLIGRYLNSLGIDGSEFVLDDGCGLSRENRISTNAIVSVLENIRQRGRWNYFRQTLAVGGVDGTIRKYFRQAKYKGKIVGKTGYIRGVRAFSGVVETENGDFLFSILTEGGSSYVRRAINDISEVIVDNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMY7</accession>
    <name>A0A1U9NMY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase YdgJ</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydgJ</name>
        <name evidence="3" type="ORF">STSP2_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69281">
        <property type="protein sequence ID" value="AQT69281"/>
        <property type="gene ID" value="STSP2_02470"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02470"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="151"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="389" mass="42929" checksum="092997F2246CECB8" modified="2017-06-07" version="1">MAFERTLKMGMVGGGPDAFIGDVHRKAARLDGKIEIAAGAFDVDPAKSRQMGEQLCLDPGRAYDTYQDMIKGEMARPEGERIDFVSICVPNNLHFPIAKDFIEAGFNVMCEKPMTITLDEAKELEKLVEKHGVVFGLMHNYTGYPMVKLARDLVAGGDFGKVRKVVVRYIQGWLATKLEDTGLQQATWRTDPKQSGAGCLGDIATHAENLAEYITGLKIENICADITSFVPGRPVDDDVNCLLRFEDGVKGILHATQIATGQENGLSIWVHGENKTIEWHQEEPNALYLKDNEGPMQVWRRGNPYVEEVSAAAARGCRIPPGHPEAFIEAMANVYCNFADTIWAKLEGQEADALVSDFPKVGDGVRGMSFIETVMESAKSDQKWTAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN24</accession>
    <name>A0A1U9NN24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4-mannooligosaccharide phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02424"/>
    <dbReference type="EnsemblBacteria" id="AQT69235">
        <property type="protein sequence ID" value="AQT69235"/>
        <property type="gene ID" value="STSP2_02424"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02424"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="347" mass="39091" checksum="94B26F97CECE5492" modified="2017-06-07" version="1">MLVERFAENPIIRPQDVTPSRDDNEVVGAFNAGATVFRGQILLLLRVAERPKDKAADEQVAPILNPHTGEIEHFRAKNDDPAVEIPDSRSFFYNGKINLTSISHLRIARSDDGVHFEIDDRPAVYPQTYYETYGLEDPRITQIGEKWYITYKVVSDHGICTGLLSTEDFEYFERHGIIFCPENLDVVLFPEMIRGEYWALTRPVPMYIGPKAIWGARSDDLIHWGGHCPVITPRPGEFDGGKVGGSCVPIKTDEGWLEIYHGSDIEDRYCLAAALHDLEDPSKVIARSKEPLMQPETDYEIKGFYGNVVFACGHVEKDGEIIIYYGASDEHTAGARTTLDKIMNTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN34</accession>
    <name>A0A1U9NN34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ferredoxin-dependent glutamate synthase 1</fullName>
            <ecNumber evidence="16">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB_1</name>
        <name evidence="16" type="ORF">STSP2_02434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="16"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02434"/>
    <dbReference type="EnsemblBacteria" id="AQT69245">
        <property type="protein sequence ID" value="AQT69245"/>
        <property type="gene ID" value="STSP2_02434"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02434"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000189674">
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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        <property type="entry name" value="Glu_synth_asu_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1516" mass="167538" checksum="5521E80CAA34DC7E" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN42</accession>
    <name>A0A1U9NN42_9BACT</name>
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        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ_7</name>
        <name evidence="10" type="ORF">STSP2_02551</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
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        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02551"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
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    </dbReference>
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        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
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        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323966" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1267" mass="143154" checksum="F0A9D8BDC81626D7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNC4</accession>
    <name>A0A1U9NNC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69403">
        <property type="protein sequence ID" value="AQT69403"/>
        <property type="gene ID" value="STSP2_02592"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02592"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12147" checksum="0DF1465EA5586FC8" modified="2017-06-07" version="1" precursor="true">MKTKVLKLAIIVCVLGSVMLSTLGCGSPYVGKNLPANKYQVGGGFESKIRPDVPGTAMLVDMDSRRILISEQLDAGEEFSYTGEQLSILLDQLDIESREVVPVLFFVPNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NND5</accession>
    <name>A0A1U9NND5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02317"/>
    <dbReference type="EnsemblBacteria" id="AQT69130">
        <property type="protein sequence ID" value="AQT69130"/>
        <property type="gene ID" value="STSP2_02317"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02317"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="669" mass="75588" checksum="980B1194455F9C52" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE0</accession>
    <name>A0A1U9NNE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional repressor KstR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">kstR2</name>
        <name evidence="3" type="ORF">STSP2_02534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02534"/>
    <dbReference type="EnsemblBacteria" id="AQT69345">
        <property type="protein sequence ID" value="AQT69345"/>
        <property type="gene ID" value="STSP2_02534"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02534"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22291" checksum="9E994FEB7365671A" modified="2017-06-07" version="1">MPGKSGTRGRILRLASTLYSTHGCDATTLDDILTAGGITKGAFYHHFKSKEQLCEKIIDQLTNDYEELMGSVSRNADPIDRLRLIVYKLDELHTSGKWVNCRLIFRLYTGTHKSNPQIQYKLSQFWQWYTNEFRELLVECRQAGQLTEEISLETQLELILATMAGAVTLDQVEPTPHGFAHLVDTVLSAMSVEPVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL2</accession>
    <name>A0A1U9NNL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">fhs</name>
        <name evidence="7" type="ORF">STSP2_02702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02702"/>
    <dbReference type="EnsemblBacteria" id="AQT69511">
        <property type="protein sequence ID" value="AQT69511"/>
        <property type="gene ID" value="STSP2_02702"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02702"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="587" mass="63711" checksum="7129D6D22B625AFD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNS7</accession>
    <name>A0A1U9NNS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">STSP2_02756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02756"/>
    <dbReference type="EnsemblBacteria" id="AQT69563">
        <property type="protein sequence ID" value="AQT69563"/>
        <property type="gene ID" value="STSP2_02756"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02756"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="425" mass="44751" checksum="A99D308DE47A2A47" modified="2017-06-07" version="1">MDALEIHGPVQLDGTIEISGSKNAALPIMAAALLAPGESVIEGVPKLVDIAVLERLLASLGVKVCRDETGSIHIDATTIEKPIGEYDIVRKMRASICILGPLLARCGHVEVSMPGGCAIGDRPVDIHLRGLRELGAQITLENGYIVADAPQGLKGGAIFLGGPFGSTVLGTANILMAATLAEGKTVIECAACEPEICDLANFLNEMGAKITGIGSPRLTVEGVSGLSPVKYKVIGDRIEAGTFMVAAAITRGRLELKNCDLGHMLAVVDVLRKIGVRIDETNDGCVVTCTGRLSPVDITTQVYPGFPTDLQAQLMALLALADGNSVVTEKIFPDRFMHVAELNRMAANIRKEGPTAIIAGVERLVAAPVMASDLRASAALVLAAMAAEGTTLINRVYHIDRGYERIEEKLNPAGASIVRKQVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNU1</accession>
    <name>A0A1U9NNU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69280">
        <property type="protein sequence ID" value="AQT69280"/>
        <property type="gene ID" value="STSP2_02469"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02469"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="331" mass="37080" checksum="BFCBED8E243A232E" modified="2017-06-07" version="1">MARPVTMFTGQWADMPLEELAKTMAGFGYDGLELACWGDHMDVFKAAEDMDYCKKQRAILDKYGLKLFAISNHLAGQLTCDPNDDSRSDGFAPADCAGDADKKREWAIEAMKNSARTAKNLGLDVVNGFTGSPIWHMLYSFPPVSDQMIDDGFKYFAEIWNPILDVFDECGVKFALEVHPTEIAFDILTAKRALEAVGNREAFGFNFDPSHLHWQMVDPVKFIQEFPDRIYHVHMKDAALQLDGRTGILASHLNFGQPMRGWDFRSLGHGGVDFEEIIRALNVIGYEGPLSVEWEDSGMDRLHGAQEACDFVKNVDFKPSGVAFDAAFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNV3</accession>
    <name>A0A1U9NNV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69579">
        <property type="protein sequence ID" value="AQT69579"/>
        <property type="gene ID" value="STSP2_02772"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02772"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="298" mass="34889" checksum="76CB94B22F11531B" modified="2017-06-07" version="1">MCMITIGQNRQCINQDHKKEPIFRCIQILLWSFRKIWFTIDIRSEFTTLHKIEGISMNVLKRQTKRTVYFGIKYFVSASWSLDRAHLLKFQQHLLERGLDFSQTNIQGNSFVLSRTQPSPLQIRLEANGPQVSSINVFAQKPTYDLSLFIRDADVVFSAYRETWRAEQYQVIRKDAKIQHLYSCTEHAFKYIWERRLGQSPGDFSSLGGRPVAGGGLRLILPPHKKEGEETHSAEIRIESFLRDTRSLFVETGFVWPTPQTIKKDDSFDVDKQMNFVEHYATNEVWQFLSEQETENEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW3</accession>
    <name>A0A1U9NNW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69589">
        <property type="protein sequence ID" value="AQT69589"/>
        <property type="gene ID" value="STSP2_02782"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02782"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034756">
        <property type="entry name" value="T2SSM_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10741">
        <property type="entry name" value="T2SSM_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="213" mass="24347" checksum="A44EA63666DB6DA7" modified="2017-06-07" version="1">MNLKKGSVISWILLLVLCAACITVYLTVLQNSKNQLSETKKLLAEKQDQLEFMEFGQGKQQLNEMRNNLATSSDTLTKFVCPVESISDITFSISQLASDLGLEQYSCEQRKKSPYEKMEGMNNLAVCRLHINFRSEFNEFARFLNKLEKHQPVIFIDKFSIQPDSKETGKYVDMVLAFFVDIGPDSQKELTHLLAKSHELANANDRQDSERPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNW7</accession>
    <name>A0A1U9NNW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69535">
        <property type="protein sequence ID" value="AQT69535"/>
        <property type="gene ID" value="STSP2_02726"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02726"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="478" mass="54294" checksum="B6390EE52B396BD0" modified="2017-06-07" version="1">MAGRSSQSNAMLYTVITFVSLFIIATVVAVIFYLKYEDEKMISQKNIEKADQLATDSQFRQLSRTVGDIKSGETYIGAMQDYLDQMVTVVTGEKIDTSARVKVNDTKKEINQTLEALGDEFAAAYGPEGVDLLQTLVQLKNSLDAQRQQQENLRQQLDKLQQKYAIDQQAWEQTKEEIITDKEQYQAQAQEIQEKYDELNQQMQQSADQQVQIWKDRYEKTENAREELLVELENTEENLQETKQELSDALAKLEEIKPRPDIEVAAYQPDAEVVAVDLQTDVVYLNIGSDQHVYRGLTFSIYDRSAPVPEDGEGKAEVEVFRVDEKVSSARIVSSSKKNQIVEGDKAVNLIWDEETSNDFVVVGSFDFDRDGLVDRDGKEKVEQLIERWGGKIKETVDINTDFLVMGTEPEVMAEPTASEMAIDPDAEDKYQAQLDRVDAYYKAIEKAETLAVPKFNLKRFLLLTGYETTAKQSEPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP49</accession>
    <name>A0A1U9NP49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">zupT</name>
        <name evidence="13" type="ORF">STSP2_02874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates zinc uptake. May also transport other divalent cations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69679">
        <property type="protein sequence ID" value="AQT69679"/>
        <property type="gene ID" value="STSP2_02874"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02874"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00548">
        <property type="entry name" value="ZupT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023498">
        <property type="entry name" value="Zn_transptr_ZupT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31117" checksum="A79181889ABDD3BB" modified="2017-06-07" version="1">MGSVWMAFGLTLFAGLATGIGSVIAFFAGRTNYRFLSVATGFSAGVMLYVSFVEIFFKGADSLVAVYGERWGQWVNVMSFFGGILFIGVIDNLVPSAENPHEVHTAEEQEPLHDENAPMPDFDHVPEVAGAHDHRVDHSKLMRMGMFTALAIAIHNFPEGLATFLAALEDPSVGLAIAVAIALHNIPEGISVSVPIYYAVGSRRKAFVYSFLSGLAEPVGAGMAYVAMRLIVGEGGVFPPQVMGVLFGGVAGVMVYISLDELLPTSRAYGKGHDSLLGLIGGMAVMAVSLLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP89</accession>
    <name>A0A1U9NP89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Miniconductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mscM</name>
        <name evidence="5" type="ORF">STSP2_02849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02849"/>
    <dbReference type="EnsemblBacteria" id="AQT69655">
        <property type="protein sequence ID" value="AQT69655"/>
        <property type="gene ID" value="STSP2_02849"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02849"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="432" mass="48199" checksum="E51172BCE9A6BFCE" modified="2017-06-07" version="1">MIDALSSGESGTAFVVRVKNLIFGEESAVPHADVISAGAVLVGLFVLAVIAHFIAKKIFFKGVEKVVKRSAAKWDDALVNHKFFDRLAHLVPGIVIHATACGLFGEGSTLCTVLRNGAQVYLVLAGAFAFDAFLSAGLAIYKEFEVSRRVPIKGFIQIVKVLMYSLAAVFVLAILLSNNPAKIFAGMGAMTAVIILVFRDAILGFVAGIQLTANDLVRIGDWIEVSRYGADGDVVDITLTTVKVQNWDKTIVTVPAYSLISDSFRNWRGMSESGGRRMKRCIYIDMTTVKFCTPEMRERFKKFDYLGGYIERRQEEIEKYNAEHQIDNSVLVNGRRMTNIGVFRAYASEYLKNHPMVNQEMTMMVRQLEPTPHGLPVQIYAFCKDKRWVHYEGVQSDIFDHLLAVVGEFELRLFQEPSGADLNSEFIVRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPA3</accession>
    <name>A0A1U9NPA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">galE_2</name>
        <name evidence="2" type="ORF">STSP2_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69440">
        <property type="protein sequence ID" value="AQT69440"/>
        <property type="gene ID" value="STSP2_02630"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02630"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="358" mass="39939" checksum="6F9BF652486A9F48" modified="2017-06-07" version="1">MKVLVTGSQGYIGTVLTPLLKAQGHEVTGLDVDLYEQCTFGTDMPDIPFIHKDVRDIALDDLQGYDAVIHLAALSNDPLGFLNPELTLDINYRASAKLAELSKAAGVKRFVFSSSCSNYGAGGEDFLTEESPFNPVTPYGESKVLAEKAISALADDSFSPIFLRNATAYGVSPRLRFDLVLNNLVAWAFTTGLVYLKSDGTPWRPIVHVEDISRAFGAVLQTPRSAIHNQAFNVGVNSDNHRIKDIALIVSDTVPGCRIKIASNASPDKRCYRVDCSKIQRIIPEFKPQWDTRKGAYELFRAYRKHGLKLEDFEGPRFQRIGHIRKMLERKKLNDQLRWQTCKITDRSQESTQSVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPD6</accession>
    <name>A0A1U9NPD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretory pathway, component PulK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69769">
        <property type="protein sequence ID" value="AQT69769"/>
        <property type="gene ID" value="STSP2_02966"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02966"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16524" checksum="7550C7705658AAE0" modified="2017-06-07" version="1">MKKYRCSGGVMSVWEAFDMDNKTKGSVLIIVVFTVALMSTLVIGILQANTEELQLMQNHVNNVQAYYFAEAGLNHAFSELRADDEWREGFSDEAFGEGSYSVTVTGSGSELVVESTGETKQGFTTKLRANIAIGSVSPHIIRKDSVERVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF6</accession>
    <name>A0A1U9NPF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_02998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69801">
        <property type="protein sequence ID" value="AQT69801"/>
        <property type="gene ID" value="STSP2_02998"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02998"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="429"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="541" mass="61691" checksum="C2322EBF6D6A36C9" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM6</accession>
    <name>A0A1U9NPM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queC</name>
        <name evidence="2" type="ORF">STSP2_02862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02862"/>
    <dbReference type="EnsemblBacteria" id="AQT69668">
        <property type="protein sequence ID" value="AQT69668"/>
        <property type="gene ID" value="STSP2_02862"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02862"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="233" mass="25540" checksum="41B9B231E4DFE889" modified="2017-06-07" version="1">MSSSTKKAVVLLSGGLDSATTLGIARNEGFDCYAMTFRYGQRHNVEVECARRVAASLGVAEHRIIDIDLKQFGRSALTDDTLAVPKDREDIDDTSDIPISYVPARNTIFLSYALAWAEVLDAFDIFIGVNATDYSGYPDCRPEFIDAYEKMANLATAAAVTGTQKYSIHTPIIKLSKADIIKTGTSIGVDYSLTHSCYDPDPDNKPCARCDSCKLRLRGFQQANLTDPVQYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPN0</accession>
    <name>A0A1U9NPN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ffh</name>
        <name evidence="10" type="ORF">STSP2_03081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03081"/>
    <dbReference type="EnsemblBacteria" id="AQT69881">
        <property type="protein sequence ID" value="AQT69881"/>
        <property type="gene ID" value="STSP2_03081"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03081"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="473" mass="52098" checksum="79B54D1EC1B1DF8B" modified="2017-06-07" version="1">MFDALTQKFNSVFKSLSGKGKITEANVKEAMREVRKALLEADVNYKVAKQFCKDVQEAAMGQEVVKSLHPGQVMVKIVNDELTKLMGPVDTQVYFVSPGPTIIMLAGLQGCGKTTTAAKLAKYLISKGKKPMMIADDLQRPAAIDQLVTLGEQIDVEVYTEDTKDAVRVAKNGIKRCKQGGYDVAILDTAGRLHIDEEMMGEVSDVAKAVTPHQIYLVCDAMIGQDAVTSAKEFNDRLELDGVILTKLDGDARGGAALSVKAVTGKPIKFIGVGEKLDKIEEFHPDRMASRILGMGDVVTLVEKAQEQYDEEEAKKMQTKMQKGTFGFDDFLKQMKAMKKMGGMSSMLKLLPGVGQQLGNMDIDDGEIGKMEGIIHSMTEEERRDPETISASRRRRIARGCGRTPNEVASLVKTFKRSRDMMKVVSSGGMGGLKGLMSGRMDMASMMQGGKKIKQRSKRKKTIRRRGKIKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPP9</accession>
    <name>A0A1U9NPP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69912">
        <property type="protein sequence ID" value="AQT69912"/>
        <property type="gene ID" value="STSP2_03112"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03112"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10461" checksum="2395997CC1FA17B1" modified="2017-06-07" version="1">MSVFVAMSRLGEHLHFDDVRHYVDDHRDFLTSRHLWHMVRVVLLAAIILLFLIFSRRAKGDFETYSTILSCFETASTNTVCELSEAGNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPS1</accession>
    <name>A0A1U9NPS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytochrome-like protein cph1</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cph1_12</name>
        <name evidence="6" type="ORF">STSP2_03113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69913">
        <property type="protein sequence ID" value="AQT69913"/>
        <property type="gene ID" value="STSP2_03113"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03113"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="131"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="274"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="508" mass="56868" checksum="2FFC83D4E23A0725" modified="2017-06-07" version="1">MVEKRVVIVEGVNSEARDLAEVLNRLGYTVADVVRGGGDVAERLRDIESDVMVADAQFNDGARAYEVLGDWCAREGMPAVYVFDEKSQNRPVPEDMGVCYTLYVPFGDQELQHGIEAAVYRMRSAKQLEESEARFRLFYENSPVAYQSLDAEGRILEVNPAWLEMLGYERSEVLGRSIKEFLMESSSEGFDGMFKDFKESGKLRGHSVCMVCSDGRKRFIEADGNICHDENGRFVQTHCVMRDVTEARVAEEEKERCLKLLEQKNKELEQIIHIASHDLRSPLVTIRGFGMELADACERIGELLKDVELGQEKEKDLQELLGAEVPESLKFISAGTDKMDSLISSLLRLARIGTAALDIQPLDMNMLVTNIKHSMEFQIQEKEVDVIVEEGLPGCMGDPTQISQVFSNLMGNAVKYLDGSRKGVIRVSGERKGDWSEYCVEDNGGGIEQDQLDRIFEMFYRLDPDGSEGEGLGLTIVRRIVSGHEGRIWVDSEVGKGSKFFVALPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV9</accession>
    <name>A0A1U9NPV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromosome-partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">parB_2</name>
        <name evidence="4" type="ORF">STSP2_03139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69939">
        <property type="protein sequence ID" value="AQT69939"/>
        <property type="gene ID" value="STSP2_03139"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03139"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="569" mass="63335" checksum="8588DBBFB5DD3568" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ58</accession>
    <name>A0A1U9NQ58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ORF">STSP2_03062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03062"/>
    <dbReference type="EnsemblBacteria" id="AQT69864">
        <property type="protein sequence ID" value="AQT69864"/>
        <property type="gene ID" value="STSP2_03062"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03062"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20424" checksum="8FF3DA1D7E8ADE09" modified="2017-06-07" version="1">MQWYVLRVASNKEMRVRDALEKKMRTEGITSVGRIIVPVEHVKRIRGGKQRVVTRKLYPGYVFMELETKEGGHPHDDAWYIIKETMGVGDFVGTDGIPTPMRDTDVAKMLKEAEKPEEAPNIKVEFQKGDIVKINEGAFENFEGVVDSIDSERGVVRVIVSIFGRSTPLDIEYWQIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ59</accession>
    <name>A0A1U9NQ59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70071">
        <property type="protein sequence ID" value="AQT70071"/>
        <property type="gene ID" value="STSP2_03273"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03273"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021451">
        <property type="entry name" value="DUF3102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11300">
        <property type="entry name" value="DUF3102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="286" mass="33066" checksum="0796EB49BEFACD5A" modified="2017-06-07" version="1">MTTINKSECDKMLKQVPLDVRDNLEQQFHSNELSSEVDVAETINALHRSICDMLSITVSKAIEIGGLLTEQKKEVGHGNWSTWIETNLEFKQRAASNYMRIYEHRDEIKIAQCANLQECYRVIVGEDNHNDIDDDHEIPDDQNVNQCCKGKEEKIKRPKLVGKSVAKPNFHSYTANDIINNDSLAVGDAVILREKDVPEFHLYIKESAESVRRYTYERTGYETVSASGLKFDYIVYCKLLRESCDDAVALREKIKEQEMAELERKFDFAELWREDPLECEGEFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQD2</accession>
    <name>A0A1U9NQD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_03128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69928">
        <property type="protein sequence ID" value="AQT69928"/>
        <property type="gene ID" value="STSP2_03128"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03128"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11654" checksum="27619E577564B24A" modified="2017-06-07" version="1">MGHAAEKTESRKMLNATDKQIIAAKAEGLMLFDFGELGMIVAKSRANAQRMMIERGNSEGSVRYWHGTVVTGKVELCDRWGENSYMESPDVIIAQGEGFRVTDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQJ7</accession>
    <name>A0A1U9NQJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase HcpC</fullName>
            <ecNumber evidence="2">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcpC_4</name>
        <name evidence="2" type="ORF">STSP2_03199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03199"/>
    <dbReference type="EnsemblBacteria" id="AQT69998">
        <property type="protein sequence ID" value="AQT69998"/>
        <property type="gene ID" value="STSP2_03199"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03199"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012323978" evidence="1">
        <location>
            <begin position="23"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="617" mass="69244" checksum="127B3AC64BB9BB4C" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQN2</accession>
    <name>A0A1U9NQN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_03425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70219">
        <property type="protein sequence ID" value="AQT70219"/>
        <property type="gene ID" value="STSP2_03425"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03425"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21284" checksum="9EBE0CC470530DF1" modified="2017-06-07" version="1" precursor="true">MKSNKNMTRSRLYPVALVGMGLQMCIFALLATVSPVQAATGEYSLMVQRSPVDGGTVTPDAGVHSYNKAEKTTITASPRPGYRFAGWLGDVGNNSSASTTITVDSPKMVVAVFQREDEEETVILTEEQSPQSQASGPLHRNSRGVGAGGGASPAGGGFPIASGDDDPEIIPVDPPETPEIPEPATILLLGAGGLLLRRRPRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQV8</accession>
    <name>A0A1U9NQV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="7" type="ORF">STSP2_03096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03096"/>
    <dbReference type="EnsemblBacteria" id="AQT69896">
        <property type="protein sequence ID" value="AQT69896"/>
        <property type="gene ID" value="STSP2_03096"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03096"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="30737" checksum="60F5EE94A52A2148" modified="2017-06-07" version="1">MNILAIDIGNTKIKTAFFLDDREQFTESVHSDELGKLEDKLTKAWEEVPVVAGSTEDKRDGVIVVCSVNEKLTQEVRKMVDRALGEKIKVIGEDVRLPIEMGVENKKEVGTDRVVAAAAAFAVIEDAVVVADFGTAVTIDLVDEEGVFMGGVIAPGLEMGADALHEGTDKLPRVELHEPMSPVGGNTKDAINAGIYYGAVGLLRTMAEMYAEQVGRWPQTIVTGGGSEMLKARCPFVDAWVPDLVVKGIILAYKKHLADQAQIAEWDEEDQQQGKKDKGEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR48</accession>
    <name>A0A1U9NR48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sensory/regulatory protein RpfC</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpfC_3</name>
        <name evidence="9" type="ORF">STSP2_03303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70100">
        <property type="protein sequence ID" value="AQT70100"/>
        <property type="gene ID" value="STSP2_03303"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03303"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="308"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="555"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="8">
        <location>
            <begin position="726"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="2">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT70100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="832" mass="92669" checksum="FFA6DA080089208D" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR86</accession>
    <name>A0A1U9NR86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tkt</name>
        <name evidence="10" type="ORF">STSP2_03460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03460"/>
    <dbReference type="EnsemblBacteria" id="AQT70254">
        <property type="protein sequence ID" value="AQT70254"/>
        <property type="gene ID" value="STSP2_03460"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03460"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT70254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="675" mass="73407" checksum="3847962D5F96FA51" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRT5</accession>
    <name>A0A1U9NRT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nreB</name>
        <name evidence="14" type="ORF">STSP2_03526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03526"/>
    <dbReference type="EnsemblBacteria" id="AQT70320">
        <property type="protein sequence ID" value="AQT70320"/>
        <property type="gene ID" value="STSP2_03526"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03526"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="284"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AQT70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="381" mass="43001" checksum="758AF7F9E7FBA766" modified="2017-06-07" version="1">MHSREKMRAKNTALWNEQAGPIMEAFFSHTLEPMAILDAEFNFIRVNDAYAKIASRESDDFIGENHFDLYPHEENERIFRSVVDNKKPYLALAKPFEHPDQPERGTTYWNWKLFPILDYKGAIKYLVFTLEDVTAETRAKERLKEANEKLEKRARQLQKMSAALSAAEDRERERLSEVLHDDLQQRLVAAKFQINIAASRSNMNEDVAEQLEEAGKLLDGAIKKSRNLSHELCPPVLSQYGLGAAFEWLAVEMGDLYDLTLEVIIGTEAEPDTEEIRSFAFKSVRELVFNAVKHAGVDRVRVNMQRSGEQIQIIVSDEGKGFDVDSVLGGANKGFGLLSMRERLDVLGGSLLIKSSAGEGSEFVICLPGEESNETEREAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG61</accession>
    <name>A0A1U9NG61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Distal rod protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgG_2</name>
        <name evidence="5" type="ORF">STSP2_00060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00060"/>
    <dbReference type="EnsemblBacteria" id="AQT66922">
        <property type="protein sequence ID" value="AQT66922"/>
        <property type="gene ID" value="STSP2_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00060"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT66922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26111" checksum="621BAF3B6B21C6B2" modified="2017-06-07" version="1">MTEINPNMGSSVNALMQEYRAITNNLANASTPGYKSRTTSFSSIMEQKLGPDGKPEDTIKAHTGINFMQGNLRQTDRRLDIAINGKGFFVIETPDGPRYTRNGSLHLNHNRQLVDTAGNNIAGQNGPIVLPQGATVQQLSFGPDGTVSANGMNIGQLSLVDFGNKVGQLMPTEHGAFIAPEEVRPQPATQTEVKQGFQEASNVGITQELVKLITVNRLYEANMKIISKSGENTKSILNVAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NG63</accession>
    <name>A0A1U9NG63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basal body L-ring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgH</name>
        <name evidence="7" type="ORF">STSP2_00057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00057"/>
    <dbReference type="EnsemblBacteria" id="AQT66919">
        <property type="protein sequence ID" value="AQT66919"/>
        <property type="gene ID" value="STSP2_00057"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00057"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013092482" evidence="6">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT66919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22695" checksum="9139A62FCEDAB3A5" modified="2017-06-07" version="1">MKNIYTTITILALLTLFTAGQSYAGSIWAKKSKNAKSMYSDDTARKIGDILTITINEATRIDSNVERDLEKEANRSVDWDGKVGIDHVLPSVPGFSVSLGDGSSQSLEGQAEYKDERTIEDNITVVVEDVQPNGNLVVLGSLVRDIAGDEQTIEVGGIVRPSDISFENNVLSSQVADFYMVVKNDGPSKTYNEVGWLGQILDFIWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGF5</accession>
    <name>A0A1U9NGF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative electron transport protein YccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yccM_1</name>
        <name evidence="6" type="ORF">STSP2_00159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00159"/>
    <dbReference type="EnsemblBacteria" id="AQT67021">
        <property type="protein sequence ID" value="AQT67021"/>
        <property type="gene ID" value="STSP2_00159"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00159"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="579" mass="64113" checksum="D32F638602286476" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGG7</accession>
    <name>A0A1U9NGG7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00160"/>
    <dbReference type="EnsemblBacteria" id="AQT67022">
        <property type="protein sequence ID" value="AQT67022"/>
        <property type="gene ID" value="STSP2_00160"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00160"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="DUF362" evidence="2">
        <location>
            <begin position="97"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35765" checksum="831EBCC7A1430FF4" modified="2017-06-07" version="1">MQANNDKNIDRRDFMKRAAGGAGIIAASAIGAGLLYDKAGPRIRPKREQVHLPDFSVPALEGKIMCVAKGSDRGANVKKAIDQLGGIERFIKPGETVLIKPNVAFASPPTLGATTNPELIEAVVKLCYDRGKASQVIVTDNSINDPASCFRLSGVGDAAQKSGARIILPRPGMFEHTTLKEGKLIRDWPVLWEAFGGVDKVIGITPVKDHHRSGASMTMKNWYGLLGGRRNIFHQNIHTIIEELARMVTPTMVILDGTTVMMSNGPTGGSVSDLRKKNELIVCTDQVAADSYGASLLERSIEELPHLEMAAKAGVGTIDYQSLKPIFVDVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGJ3</accession>
    <name>A0A1U9NGJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">cheD</name>
        <name evidence="4" type="ORF">STSP2_00015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00015"/>
    <dbReference type="EnsemblBacteria" id="AQT66877">
        <property type="protein sequence ID" value="AQT66877"/>
        <property type="gene ID" value="STSP2_00015"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00015"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT66877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17525" checksum="E7052FB54E0474BA" modified="2017-06-07" version="1">MVKTKKTVDISDAAVSRNPNEVIVTYSLGSCVGVSLYDPATKIGGMLHYQLPESKLDPEKAKRLPFMFADTGIKLLVDKMVSMGASKKRMNVKIAGGAAMSTGPKGFDIGKRNHLAIRKVFWKLGMFIDAEDIGGTSPRNMYLDIADGTLTVRCVGRDKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGK9</accession>
    <name>A0A1U9NGK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT66874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT66874">
        <property type="protein sequence ID" value="AQT66874"/>
        <property type="gene ID" value="STSP2_00012"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00012"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911326" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT66874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15945" checksum="066652972D470ABF" modified="2017-06-07" version="1" precursor="true">MSRSLLTCVMCTALAGLSVLAGCSKESDNWLIGEWAYDAQATKSNLPTNIKAEGVPDIMAEQLGAQLVEQLMSQMEGVELHFTADEVSFISAKGTETHDYKIASRPDANTIKIESEEPATFIRSGKYLCIPSAGDVDFKMYFKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGN7</accession>
    <name>A0A1U9NGN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67102">
        <property type="protein sequence ID" value="AQT67102"/>
        <property type="gene ID" value="STSP2_00242"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00242"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="59"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="254" mass="28355" checksum="BBCBDE090A3894B3" modified="2017-06-07" version="1" precursor="true">MRWCFRSVLMVLFVVAGCTGLTLTQSKWKVHDPDRPLPDTVKPASCSTQESAGEAPGDAIILFDGENLSKWSSVKGGGPAKWTVKDGYMQVKPGAGDIITKDKFGDYQLHLEWASPENDKNGGQGKGNSGVFLANNYEIQILDCYNNPTYADGTAGAVYGQSPPAVNVCRKPGQWQTYDIVFHAPEFEDGKVTQPATVTVFHNGVLIQDHWVIKGMTLWKKRPYYKPHAEKMPIRLQDHSDQVKYRNIWLRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH40</accession>
    <name>A0A1U9NH40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67239">
        <property type="protein sequence ID" value="AQT67239"/>
        <property type="gene ID" value="STSP2_00382"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00382"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="231" mass="26161" checksum="E0852A0C582BFC17" modified="2017-06-07" version="1" precursor="true">MSKHKRIRNLFLLLAVLVGAVVAMVMVQSIRERNSPAARARERQIAMAREMGFLQAQGAGAGYYVDAAEKLKSIGYSEDVFRELRKTDKALDQDLVSEEAIKLILEGCRQEEMGLKAFSLWSMDYEVEMNGKTVDWDDIYLCMQYMKNLSKSAVDQSDTFSFTTSEIWGGLFSTGVQLSEYENDILRVLGISCKTQAVAYMLDEAEGERKSELQVIESDVEKEFEKVKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH66</accession>
    <name>A0A1U9NH66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor AseR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aseR</name>
        <name evidence="2" type="ORF">STSP2_00286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00286"/>
    <dbReference type="EnsemblBacteria" id="AQT67145">
        <property type="protein sequence ID" value="AQT67145"/>
        <property type="gene ID" value="STSP2_00286"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00286"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12878" checksum="2E97BFAB95DDE459" modified="2017-06-07" version="1">MLRALGDEGRVRVVLALAEHGELCACQIVELVGLAGSTVSKHLSVLKNAGLVERRKKGRWIHYSFSCGEYGSIVMGYLKHWLDEDEQIVADREKMNEILREDPEIVCRRQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NH80</accession>
    <name>A0A1U9NH80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Foldase protein PrsA 1</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prsA1_2</name>
        <name evidence="5" type="ORF">STSP2_00268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00268"/>
    <dbReference type="EnsemblBacteria" id="AQT67127">
        <property type="protein sequence ID" value="AQT67127"/>
        <property type="gene ID" value="STSP2_00268"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00268"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012550050" evidence="3">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="214"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="384" mass="42913" checksum="2EA3EA86C2122B4A" modified="2017-06-07" version="1" precursor="true">MRLKYWVISVVLMFAVGQAAVFAAEGEKAKECEGGSCPLTKKADCEKQECPEGGKEKCDKDCDKCGTSECPKVMATVNGDAITVAELDKQLEPQFEQYKKMGREVTDRIKNMMRFRAAQGKITEKLIAEQIEEEGIKVTEKDIDAKIAELAEQNNMTVEEFLKAQEERAGVSEKEFRKRAKLGTGFEKLMEKVSAKEDLGVSEEKAKEVYMNQPVQVQASHILIDTREKDEAAKAEAKKEIEAILADVKDGGDFAEIAKEKSDCPSGQRGGDLGFFTKEKMVPAFSNAAFAMEVGEVSDVVETQFGYHIIKVTDRKAPDASKFDEEKEQIMAQEEQKNKSQFAQTYIQNLAENAEIEWNEEYDPRQQMPQRPAQPVSKGGAQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHD3</accession>
    <name>A0A1U9NHD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein Omp85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bamA</name>
        <name evidence="7" type="ORF">STSP2_00477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00477"/>
    <dbReference type="EnsemblBacteria" id="AQT67333">
        <property type="protein sequence ID" value="AQT67333"/>
        <property type="gene ID" value="STSP2_00477"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00477"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010711852" evidence="5">
        <location>
            <begin position="28"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="275"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="783" mass="87323" checksum="F9D8DCE752B507C7" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHF7</accession>
    <name>A0A1U9NHF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsH</name>
        <name evidence="9" type="ORF">STSP2_00327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00327"/>
    <dbReference type="EnsemblBacteria" id="AQT67184">
        <property type="protein sequence ID" value="AQT67184"/>
        <property type="gene ID" value="STSP2_00327"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00327"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="216"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="690" mass="76582" checksum="D020C7E339D7A4B8" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHH8</accession>
    <name>A0A1U9NHH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67227">
        <property type="protein sequence ID" value="AQT67227"/>
        <property type="gene ID" value="STSP2_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00370"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="32255" checksum="2BDCF4875342C223" modified="2017-06-07" version="1">MKKLQLVVYLSLVILVGIIAGLSLRKNFGEKLYDMLDASIFFEISDRQFSDPELMNNVPSKSFASEKIKVRLKADPLMESETEVFREISLNVPLEPEEENGDLMYAFDSDMFRFSVTAEGTLPALIEVVEEQLKNYDVSYDPKWFVHVRSKLVSESDESLFLKGMSIDTEDIRADSPEQALYNAVLYESVRIFIRRKEVKLIEEGSNHLYIFPKFHRPNISILWYLFEDEKGLCSGGFTYKHEHGYSQDSIREAAGYLKTILQLDEKAGKGAVDSSGSASVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHL8</accession>
    <name>A0A1U9NHL8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">STSP2_00144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00144"/>
    <dbReference type="EnsemblBacteria" id="AQT67006">
        <property type="protein sequence ID" value="AQT67006"/>
        <property type="gene ID" value="STSP2_00144"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00144"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT67006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33161" checksum="329165F570F584AF" modified="2017-06-07" version="1" precursor="true">MPKAKIIIFGDPERKYATEASERFIRFVDDRVDILANCFMGDCAVDFLRKADFAVVFGGDGTILSAARDLCEADVPVIGVNVGKLGFLAEFSVDELEELFEDILAGQTKIEKRMILHCSISRGKEPIFESTAVNDVAISAGAPFHMIDLKMTVQGQSLASCVGDGLIISTPTGSTAYNLSAGGPILSANLSAFVVTPVCPHSLSFRPIVISDKSIIEVESGRVNDNTTITLDGQISHKLKKNDVVKVFRHHGSFLVVNNPMRTQWDTLAEKLSWAEKPKYRYKHELARVSPKDDVEKDEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ7</accession>
    <name>A0A1U9NHQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lpxD_1</name>
        <name evidence="6" type="synonym">lpxD</name>
        <name evidence="8" type="ORF">STSP2_00479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00479"/>
    <dbReference type="EnsemblBacteria" id="AQT67335">
        <property type="protein sequence ID" value="AQT67335"/>
        <property type="gene ID" value="STSP2_00479"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00479"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="346" mass="35828" checksum="454AD7EF04E1AFEA" modified="2017-06-07" version="1">MQSTTISISELAEKLNARLIGEGTLDVGKVNTLDAAGPTDVTFLTAEKFAEKALSTKAAAIITAAELKTSAPAQLIVDEPQAALIKALYIFAPRLEVTPGVHKTAVIDDSAQLGDNVSIGPNAVIGKNVVIGENTIIGPGCTIEEGTAIGSNSRLGPSVTIYHSCKIGDNCTIKANSTIGGTGYGYYFLDGQHRLVPHNGSVVIEDCVDIGSNTCIDRAKFGNTIVGAGTKIDNMVQIAHNCEIGRCCLIAGCTGIAGSVKIRDGAVLGGQTGVVDNVTIGPGAMLGAKTMAISDLEGGKSYFGSPAEDARASLKQTAAVKKLPEIIKQFKKLAKRVDKLESSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHQ8</accession>
    <name>A0A1U9NHQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00185"/>
    <dbReference type="EnsemblBacteria" id="AQT67046">
        <property type="protein sequence ID" value="AQT67046"/>
        <property type="gene ID" value="STSP2_00185"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00185"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013205486" evidence="1">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="283" mass="31537" checksum="853A252D555C3DBF" modified="2017-06-07" version="1" precursor="true">MKNYRLTTMSVVLLVLVCVLPVFAQSKGSIEYEGKKSSWNGYEKYDFALDGIPCYVVAPKECEPGKPWVLRARFPNYHADIDVKLLEAGYHIAFINVANLYGGPEACKRWSKMYEHMIDKYDLNAKVVLEGVSRGGLIVYNWAKRNPDKVASIYCDTPVCDIRSWPGGKGQGRGSDADWERCMKAYGLTEETAGEFTGNPIDGLDELAKAGVPVMHVVSESDTVVPPDENTRVLQKRYRELDGPILVLSIDEGTKVSHGHHFPLTSVVVDTAVDFILRYGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHT6</accession>
    <name>A0A1U9NHT6_9BACT</name>
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        <submittedName>
            <fullName evidence="7">Cytochrome c biogenesis protein CycY</fullName>
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        <name evidence="7" type="primary">cycY</name>
        <name evidence="7" type="ORF">STSP2_00461</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67318.1"/>
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        <property type="gene ID" value="STSP2_00461"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00461"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
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        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013069818" evidence="5">
        <location>
            <begin position="24"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="330"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="641" mass="72154" checksum="BB85A3E9A4940E09" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NI86</accession>
    <name>A0A1U9NI86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas9</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">cas9</name>
        <name evidence="13" type="ORF">STSP2_00800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Binds crRNA and tracrRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated Cas9 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00800"/>
    <dbReference type="EnsemblBacteria" id="AQT67652">
        <property type="protein sequence ID" value="AQT67652"/>
        <property type="gene ID" value="STSP2_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00800"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01480">
        <property type="entry name" value="Cas9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028629">
        <property type="entry name" value="Cas9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040619">
        <property type="entry name" value="Cas9_alpha-helical_lobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033114">
        <property type="entry name" value="HNH_CAS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041383">
        <property type="entry name" value="RuvC_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18470">
        <property type="entry name" value="Cas9_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18541">
        <property type="entry name" value="RuvC_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01865">
        <property type="entry name" value="cas_Csn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51749">
        <property type="entry name" value="HNH_CAS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HNH Cas9-type" evidence="12">
        <location>
            <begin position="509"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="For RuvC-like nuclease domain" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor for HNH nuclease domain" evidence="8">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1046" mass="120342" checksum="310010BB8510A5B1" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIA9</accession>
    <name>A0A1U9NIA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67246">
        <property type="protein sequence ID" value="AQT67246"/>
        <property type="gene ID" value="STSP2_00389"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00389"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035958">
        <property type="entry name" value="SecB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54611">
        <property type="entry name" value="SSF54611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21635" checksum="728F523CDFC2714D" modified="2017-06-07" version="1">MNSEAETRSHDVSLAAEASERVELVDVRLMQCSGELISFPEDGTNEFEVTGSTSEQLDTEENLIFVSVNLSLDAVKENGEDLAQICSEFLLVYRVEDWEGLSPEHFSAFADYNGVFNSWPYWRELVQNMAGRLQLPSLTLPTYRFGYLLPKERSIGKKAKDTASGPSTRKKVHKKKKSPKRKAKKKSAKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIB8</accession>
    <name>A0A1U9NIB8_9BACT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67682">
        <property type="protein sequence ID" value="AQT67682"/>
        <property type="gene ID" value="STSP2_00830"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00830"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019283">
        <property type="entry name" value="DUF2330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10092">
        <property type="entry name" value="DUF2330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012301693" evidence="2">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="537" mass="60023" checksum="06C006D641BFFB28" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIC6</accession>
    <name>A0A1U9NIC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol:disulfide interchange protein DsbD</fullName>
            <ecNumber evidence="10">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dsbD</name>
        <name evidence="10" type="ORF">STSP2_00409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00409"/>
    <dbReference type="EnsemblBacteria" id="AQT67266">
        <property type="protein sequence ID" value="AQT67266"/>
        <property type="gene ID" value="STSP2_00409"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00409"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013364406" evidence="8">
        <location>
            <begin position="28"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="515"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="648" mass="70107" checksum="C2EF6286A21CBAE3" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIF6</accession>
    <name>A0A1U9NIF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">maa</name>
        <name evidence="5" type="ORF">STSP2_00753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.79" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00753"/>
    <dbReference type="EnsemblBacteria" id="AQT67605">
        <property type="protein sequence ID" value="AQT67605"/>
        <property type="gene ID" value="STSP2_00753"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00753"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT67605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20892" checksum="CE92D3AE3D41BF9B" modified="2017-06-07" version="1">MKSEKEKMLTGDLYDGFDAELVAERGRAYELFSQLNNIGRTFQADRTKILTELLGECGQDVWVESPFYCDYGYNIILGDGVFINFNCTILDSMEIRIGDGTLIGPGVHIYSATHPTDPKVRAKGLENAKPVTIGSNIWIGGGVIVCPGVRIGDNTTIGAGSVVTKDIPANVVAAGNPCRVIREIEQHDKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NIM7</accession>
    <name>A0A1U9NIM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_00746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67598">
        <property type="protein sequence ID" value="AQT67598"/>
        <property type="gene ID" value="STSP2_00746"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00746"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012165672" evidence="3">
        <location>
            <begin position="29"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="483" mass="54380" checksum="186A463B21FA3B58" modified="2017-06-07" version="1" precursor="true">MRFVAQTTLIAVTILLIASLLPNPAVIAAETDSNTIIPELPNAQKPFVADKITIDKVWPGHRVGFFLMTADQRQYAAYYNADRQMTVAMRKLGDEQFTKFHPQTPRKEPPHGGSAPSATLGWDSHNSVTMALDRDGYIHLSGNMHGNNLTYFRSTEPYDISTLVLVEQMTGELEDRVTYPKFLTLPDGRLVFGYRHGGSGNGNNIYNVYDTDTKTWSRLLDTPLHDGQDKNNAYYLGPKVGPDGWFHMSWVWRQTPDCSTNHDLSYAKSPDLVNWYTAAGKEVELPITLETPGVIVDPIPPQGGIINGSGKVGFDHLGRAVLAYHKFDDDGNTQAYTARYEDNEWAIDKLTDWDHRWYFEGYGTLPGVDVRLGEVKPLGVDTGLMTLNYRHVKYGSGTWLLDEQLEKIGTVDLPRRFPPQVTKVTSKFPGMTRRISIDKNSSRTDNTKYVMAWESLGSRRDKPLNGPLPDPSKLTLYEIKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ08</accession>
    <name>A0A1U9NJ08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67496">
        <property type="protein sequence ID" value="AQT67496"/>
        <property type="gene ID" value="STSP2_00644"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00644"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024227">
        <property type="entry name" value="DUF3795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12675">
        <property type="entry name" value="DUF3795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11962" checksum="9CD23B75197B1F39" modified="2017-06-07" version="1" precursor="true">MSNKLNRREMLSCAGCVVALGCSTGLAQGQSKTESKTDHGSYCGIYCESCKLYRMSKSQTDPSKVKCLGCKSGKVAPHCQNCPIKACAAAKGINTHCEIFSRATVLDLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ10</accession>
    <name>A0A1U9NJ10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01074"/>
    <dbReference type="EnsemblBacteria" id="AQT67922">
        <property type="protein sequence ID" value="AQT67922"/>
        <property type="gene ID" value="STSP2_01074"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01074"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26736" checksum="52A2C116DD07812A" modified="2017-06-07" version="1">MTLLNNIITDPAPSAPKGIIYGPPGVGKTSFGASVSDSLIIDCENGAGSIKCSRTPYLASWEQILGWLRAIEQEDHPYKVIAIDTIDWLLRRIEEHVSGCAGGKTDSTLNRSHGGYGNGKQVLKNYVYQILLPVLDRIVARGIAVLLLAHAKRTEITDIDGITVEKTTPELPDGYLNVMVEWSDFVCLARIDSQDHRYLTTRETPRALAKNRYHLPESLPFEWNAFSEGITQGLSKAFNPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ17</accession>
    <name>A0A1U9NJ17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylate/amino acid/amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67815">
        <property type="protein sequence ID" value="AQT67815"/>
        <property type="gene ID" value="STSP2_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00965"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30898" checksum="3D7ED0880BA37932" modified="2017-06-07" version="1">MTGHVEKERAKGVGLLVATALLWSLGGVLVKSIEWNGMAIGGMRSAIGAVVLAFFMKREWLTFSRVQLAGAVCYIGAVLLYAVANKLTTAANVILLQYTAPIYVALLSGWFLGEKIRLYNWIAIAAAIGGMVLFFVGEVSAEGLWGNVLGVATGLSFGMMMLVMRKQRMEAAMGSIFLGNVFTAVLGLPFMFESMPGAVSWVNLVLLGVVQLGIPYVLYARGISRVKAIDAVMICTLEPILNPVWVLIFVGEVPGEWALAGGVVVLVAVTSNAVEATLRNGKARREKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ30</accession>
    <name>A0A1U9NJ30_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="9" type="ORF">STSP2_00883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00883"/>
    <dbReference type="EnsemblBacteria" id="AQT67734">
        <property type="protein sequence ID" value="AQT67734"/>
        <property type="gene ID" value="STSP2_00883"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00883"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33232" checksum="230D598E5A5DF77F" modified="2017-06-07" version="1">MPAIRIATRASKLAIAQTKLVCNMLREVNADLQIELVEISTRGDRDKSDFLYKSSSSVGFFTSELEKALLENAADVAVHSFKDLPTAITPGLAITAVPKRVSPADALICSDGSTSIKGLKPGAVVGTSSVRRIAQLKHLRPDVHARPCRGNVDTRIGKLRGGQYDALILAHAGLIRMGKEDEISAVLPFEDFLPAPAQGALAIQTRSDDKTANVIVSQIDDNGARLRAELERRILARLHGGCSIPLGALAMVEGDAVSISAMIADPAGEPFVREQIRAQRQDAEAAADELAESLLANGGAEILARFNRDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ67</accession>
    <name>A0A1U9NJ67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS</name>
        <name evidence="8" type="ORF">STSP2_00927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_00927"/>
    <dbReference type="EnsemblBacteria" id="AQT67778">
        <property type="protein sequence ID" value="AQT67778"/>
        <property type="gene ID" value="STSP2_00927"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00927"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT67778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30855" checksum="C48813F8264CDC90" modified="2017-06-07" version="1">MEAFFEDLYAYAAAYGLRILAAIIVFAVGIWLARLLSGLAEMAALKSQLEENFSRFLRNASYATLIVIVAVAALGVLGIPTASIIVLIAAAALAVGLAIQGSLANFASGINLSLDQPFKVGDIVEIANRRGKVNQIRLFTTIINTPDNVRIIIPNSRITSTSICNYTVNGTRRLDLTFNVSYEEKIDRARHIIMNVLAMDARVLADPEPVVAIKELGDSAIRFAVQPWVRAADYWQLKYDLNTEIKQALDENHIAIPYPHREIHVIGSSPASHQEHAPIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ77</accession>
    <name>A0A1U9NJ77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67971">
        <property type="protein sequence ID" value="AQT67971"/>
        <property type="gene ID" value="STSP2_01125"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01125"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18676" checksum="DA5F6E88FC3CD26F" modified="2017-06-07" version="1">MEQQMNSYGMTVVVMTNQRGDIRWELGRMLDQLGVRCAYCSDMYEVAGEVVDTERRRAMVLLDTEKLSEGNMSLVDFCLANNIRIACVGTLGAAKSMSLISKVISHGVPVFQNTASLREYILTACDGKAKPEMDAEKTRCQKGNTAGKKAGTKREIVISQDELDALLGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJ98</accession>
    <name>A0A1U9NJ98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional NMN adenylyltransferase/Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01157"/>
    <dbReference type="EnsemblBacteria" id="AQT68003">
        <property type="protein sequence ID" value="AQT68003"/>
        <property type="gene ID" value="STSP2_01157"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01157"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16747" checksum="D019CC90CA2F27FA" modified="2017-06-07" version="1">MAQKGKYTYSWPRPAVTCDALVFRTDTPTPQLLLIQRGTEPFKGNWAFPGGYVDIDEELHHAAARELAEETGLQNMDLKQYKTVGTIGRDPRGRQITVVYWGIADPSNTDVKGADDADLAQWFPVDDLPPMAFDHAEIAASALKELSILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJA8</accession>
    <name>A0A1U9NJA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_00979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67828">
        <property type="protein sequence ID" value="AQT67828"/>
        <property type="gene ID" value="STSP2_00979"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00979"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012798486" description="PEP-CTERM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT67828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="361" mass="39167" checksum="D331207CBE434D98" modified="2017-06-07" version="1" precursor="true">MGKLTLLSFLASLFIVSSTTQAVDKKLYSIADGENDPSRRYPNGSSYIMWTDYDATFSNYRRRAVIKFDTSSVSNYTLRGAVLNIWGSSGSGSNTTAVNIYHYSYDSWSDSSIPYASSLGTKLGSVSVTKVNDVSQARKYDISLSNMPYISPYDNNLSMALVANSGYGSYFVTRNGVNWNGTANKKPYLTFRTWGETATSNGSFDDGLDSWNINSGGGTAEMAANPFGDGNLAKLTTGSPVGITQIIDTPQDAFYINFDYAFLTDTGSLDVTLTDRDGGQLLVGQLEAGDSIAEQMSHASFYLQDDSWLYLDHVTLGLQFDGASGSQVLLDNIEFSDVPEPSSILLIGLGGLLMKRKSRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJD7</accession>
    <name>A0A1U9NJD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator rcp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rcp1_1</name>
        <name evidence="3" type="ORF">STSP2_01193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01193"/>
    <dbReference type="EnsemblBacteria" id="AQT68039">
        <property type="protein sequence ID" value="AQT68039"/>
        <property type="gene ID" value="STSP2_01193"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01193"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17288" checksum="7CBEE8F54C890597" modified="2017-06-07" version="1">MARDVTILLAEDNEGHFILTRNYLQRQGIRNEIVWLPDGQATLDYLTNHVAGRQDEDEKDYVLILDIRMPKIDGEQVLQQMNADPELSQIPVIILTCTGSGGMIERYYELGAKAYIVKPVKYSTYLDAMKKVGLYPSSVPDGVKLIKRDSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJE8</accession>
    <name>A0A1U9NJE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67700">
        <property type="protein sequence ID" value="AQT67700"/>
        <property type="gene ID" value="STSP2_00848"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00848"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="156" mass="18113" checksum="305DEC8F87352A6F" modified="2017-06-07" version="1">MIAETESARSRVEAHTADYINERIRQDTEAKICYYSRRLDQIEDRINQLDQEWDIERTLQTNAAAVSMFGIIMGTTRSRKWYLLPAVVAGFLLQHAVQGWCPPLEMFRRLGFRTSQEIYREKNALKALRGDYNDINSNAEMSQDEKAQQALHATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJJ7</accession>
    <name>A0A1U9NJJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LexA repressor</fullName>
            <ecNumber evidence="15">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lexA_1</name>
        <name evidence="15" type="ORF">STSP2_01070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="15"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01070"/>
    <dbReference type="EnsemblBacteria" id="AQT67918">
        <property type="protein sequence ID" value="AQT67918"/>
        <property type="gene ID" value="STSP2_01070"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01070"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0742">SOS response</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="14">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="13">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AQT67918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23118" checksum="E29192675D0977F1" modified="2017-06-07" version="1">MPRGKIKKITPPQQEAFDEICRFIDLNGYPPTMQELADKFGITAPSVVDRVNQLIYKGYIERTGRTPRSLRVLKRTENRPGRLKPVPIVGTVAAGMPIFAEENICGEVLVDSRTLGRGEHFACEVSGESMICAGIKDGSLIIVRRQQLAQSGDIVVAFLNGEVTVKRLRINNERIELVPENSKLEPIIISNDDELRILGRVVGCKHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJN1</accession>
    <name>A0A1U9NJN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper resistance protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">copA</name>
        <name evidence="5" type="ORF">STSP2_01286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01286"/>
    <dbReference type="EnsemblBacteria" id="AQT68131">
        <property type="protein sequence ID" value="AQT68131"/>
        <property type="gene ID" value="STSP2_01286"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01286"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012911330" evidence="2">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="109"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="248"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="486" mass="54395" checksum="D8CB91C9CCA1AECF" modified="2017-06-07" version="1" precursor="true">MQIKNTLTIIALTLMITSSALAQPQDNQTQPDRNQQQTNQQQYDYESPTLRPPKEMDPPRPWAEAAKNPLPPGEPETDYTPAVVPNGRTAEYKIVDGVKVFHLIAEPIEWEVAKGLTIKTWGYNGTVPGPMIELAAGDRVRIYVTNHLPAKTSVHWHGVLLPCGMDGVSGLTQPAIKPGETFVYEFIFPDSGTFMYHPHFDSMTQEGLGLTGMIIVHDRQPDPEKRPDRDFSIMLHEWRIKAGTARPNPNEMTDFNVLTMNGKAAPDTEPLVAKTGDRVWIRYGNLSPMDHHPIHLHGYAFKIIGSDGGWAQNKEALLPETTVLVNVGSAKVIELLADNPGDWLFHCHMTHHTMNQMGHDFPNMLGMDTTGYDEKVKKLIPGYMTMGTTGMQDMTRTGMPIPDNSIPMRGYKLQFGQTVLGSMANIFRVRDDIETYDDPGPYDFPEDTVAHPASQQQLENDGITIPEPKHQINQNSSKMHKQMNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJP8</accession>
    <name>A0A1U9NJP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-invertase hin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hin_1</name>
        <name evidence="4" type="ORF">STSP2_01116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01116"/>
    <dbReference type="EnsemblBacteria" id="AQT67964">
        <property type="protein sequence ID" value="AQT67964"/>
        <property type="gene ID" value="STSP2_01116"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01116"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT67964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="511" mass="58335" checksum="8C54B89B8D2405EF" modified="2017-06-07" version="1">MQKQKSKTIRCAIYTRKSTEEGLNQEFNSLHAQREAAEAYIASQKSQGWVCLVNQYDDGGFTGGNMERPALKRLLQDIAEGQINCVVVYKVDRLSRSLMDFAKILARFEDHGVSFVSVTQQFNTTTSMGRLTLNVLLSFAQFEREVISERTRDKIAMARKRGKWSGGRPVLGYDICPDGGKLVINEAEAQQVRAIFDLFLKHKSILDTVEQLDMRGWTTKTWVTRKGHVKEGNAFNKSSLRSLLTNPLYIGKVHYKGVLYDGEHDAIVDPNVFAEVKQLLSTNRREMIRFKSGKVGGILKGLLRCKACDAGMSHAFSKKRNKRYRYYVCQNAQSRGWANCPHPSLPADEIERFVIDEIRQIGLDEKLVDQVVEESQAGIEAEIAEYRKRQKLLKKEIQRYDAELQSLASAAAYEEATNRLAGLQDRITMAQRDLSECCSHLDRLTDKKIEAEDIRQACRAFDPLWDTLTTREQWRMLSLLINRVEFDADTSSIDIIFYPTGIHRLNEEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJS6</accession>
    <name>A0A1U9NJS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gspE_1</name>
        <name evidence="4" type="ORF">STSP2_01348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01348"/>
    <dbReference type="EnsemblBacteria" id="AQT68193">
        <property type="protein sequence ID" value="AQT68193"/>
        <property type="gene ID" value="STSP2_01348"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01348"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="526" mass="57555" checksum="09D53CC3B5D594DD" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU1</accession>
    <name>A0A1U9NJU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01232"/>
    <dbReference type="EnsemblBacteria" id="AQT68077">
        <property type="protein sequence ID" value="AQT68077"/>
        <property type="gene ID" value="STSP2_01232"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01232"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013296076" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="330"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="668" mass="70827" checksum="4E50FBA5F965CEB9" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJU4</accession>
    <name>A0A1U9NJU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpE</name>
        <name evidence="6" type="ORF">STSP2_01162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01162"/>
    <dbReference type="EnsemblBacteria" id="AQT68008">
        <property type="protein sequence ID" value="AQT68008"/>
        <property type="gene ID" value="STSP2_01162"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01162"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22010" checksum="97965313869A25CF" modified="2017-06-07" version="1">MDAKEVVSKILAEANTEADSIKADAEQKVRAQKEQFDAKMDRFKKESDAKAEKAAEEARQQQLAAARMDIKKQKSQAKAQLLNDVFEKALDELVAMPDDRYKDLMTKLMIKAAQTGDEEVIIGKDEKRIDENLVKNVNRQLGSDKKGSLKLASERADIKGGFILSRGKINVNASAQVLIEQAREELDIDIASELFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NJZ3</accession>
    <name>A0A1U9NJZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68241">
        <property type="protein sequence ID" value="AQT68241"/>
        <property type="gene ID" value="STSP2_01397"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01397"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11385" checksum="FBE918612CC42E32" modified="2017-06-07" version="1">MKKVVEGKLYDTEVAEEICYYSYGYSGDFRYCSEVLYKSPNGQFFIEYDGGPYSKYSEAGGPQKVYGSSGIKLVSEDEAQSFVEENGSAEDYIKAFGEPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK48</accession>
    <name>A0A1U9NK48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67960">
        <property type="protein sequence ID" value="AQT67960"/>
        <property type="gene ID" value="STSP2_01112"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01112"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="80" mass="9251" checksum="4CA6D8AD2312CA8B" modified="2017-06-07" version="1">MKNKEAILRGLDAVIAKLKAESKGSQQQQKDIAAYQLIRDQYEAENLEAARHTYNFVMDTYLREMLPEECGETLGFKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NK92</accession>
    <name>A0A1U9NK92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01501"/>
    <dbReference type="EnsemblBacteria" id="AQT68342">
        <property type="protein sequence ID" value="AQT68342"/>
        <property type="gene ID" value="STSP2_01501"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01501"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32896" checksum="34F097372B9828E2" modified="2017-06-07" version="1">MNGITQSVHQKLLNIRDKTGEQFNHLLIRYGLERLLYRIVASKNDGMFVLKGAMLFALWRNVPGRPTRDVDLLGFGELDHERLKKVFTDACMAEVVDDGLRFDPKSIVTDDIRDDQDYHGVRVRLIGYLGNARIALQIDVGFGDAIKPAPAIIDYPTILDFPAPRIRAYHPATVVAEKFNAMIVLGLMNSRLKDFYDVYIILHHMGIDETQLADAIQSTFQRRKTPIPTELPLVFTDDFINDGNKEIQWKAFLKRSLLTDCELSFSQIVGSIQQQLWPIVLQLQNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKF0</accession>
    <name>A0A1U9NKF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_01445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01445"/>
    <dbReference type="EnsemblBacteria" id="AQT68287">
        <property type="protein sequence ID" value="AQT68287"/>
        <property type="gene ID" value="STSP2_01445"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01445"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="334"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48383" checksum="C9D5B81D03C7D874" modified="2017-06-07" version="1">MIWEKHVECMDQEQLSKLQSQRLKELVTYVYENNPIYKERLDSSGVTPDTINDISDITKLPFTTKMDMRDSYPYGLFSKPQKEIAEIHVSSGTTGNPTLVGYTRKDVALWSNVMARALCCAGGEPGDIIQIAYGYGLFTGGLGFHYGALEMGLTVIPTSSGQTARQLKIMQDFQPRILACTPSYALYMAEAAKEAGLDPRESSWEIGIFGAEPWSESMRNEIEDSLGLIATDVYGLSEIIGPGVSQECTYKDGLHIFSDVFYPEIIDPETGEQVEPGEDGELVITTLTKEGIPLLRYRTRDIVSVNYEKCECGRTSPRVSKIKGRTDDMIVVRGINVFPSQIEHVLVGMEGIGPHYQIVIDREKHSLDKVDILVELDEKRFSDEIKQLHGLETKIKKEIESILSIGVTVKLVEPKTIERSMGKAKRVVDKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKI9</accession>
    <name>A0A1U9NKI9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgE1</name>
        <name evidence="3" type="synonym">glgE</name>
        <name evidence="5" type="ORF">STSP2_01617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01617"/>
    <dbReference type="EnsemblBacteria" id="AQT68453">
        <property type="protein sequence ID" value="AQT68453"/>
        <property type="gene ID" value="STSP2_01617"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01617"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="200"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="523"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
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        <location>
            <position position="311"/>
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        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68453.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="663" mass="77463" checksum="16E29D0B124D82AF" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKL5</accession>
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        </submittedName>
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        <name evidence="7" type="ORF">STSP2_01613</name>
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        <name type="scientific">Anaerohalosphaera lusitana</name>
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        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF03633"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="800" mass="92264" checksum="D7DA18BF8A6374E0" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKN1</accession>
    <name>A0A1U9NKN1_9BACT</name>
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        <submittedName>
            <fullName evidence="5">Cobalt import ATP-binding protein CbiO</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiO</name>
        <name evidence="5" type="ORF">STSP2_01658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01658"/>
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        <property type="protein sequence ID" value="AQT68493"/>
        <property type="gene ID" value="STSP2_01658"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01658"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26373" checksum="CD4F4B82D72DC3A7" modified="2017-06-07" version="1">MSTGQAIRIENLCHSYDGGTVTLRDVSLSIGEGEKVALIGPNGAGKSTLLLAMTLFLQPKSVEGQILIHGVEACRKNEKDVRKLITPVLQNPDEQLFMPTVLEDVAFGPLNMGLEVDQARQHAMEAIEQVGLSGLEERSPYHLSAGQKRAAAIATVLSMEPRIITMDEPDTSLDPRSRDHLIELLGSLEQTLVIATCNMHFAAKTCERAVLIDDGKVVVDGPTKELLRDEELMTRHGLETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKP7</accession>
    <name>A0A1U9NKP7_9BACT</name>
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        <submittedName>
            <fullName evidence="1">LOG family protein ORF6 in fasciation locus</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="primary">fas6_2</name>
        <name evidence="1" type="ORF">STSP2_01527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
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            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01527"/>
    <dbReference type="EnsemblBacteria" id="AQT68367">
        <property type="protein sequence ID" value="AQT68367"/>
        <property type="gene ID" value="STSP2_01527"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01527"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="174" mass="18767" checksum="6B0C62195A7FB1B7" modified="2017-06-07" version="1">MSEIIVTVFGTSKARPGDSEFELAEALGTLLAKNGYTIANGGYDGTMYAAARGAASMGGKVIGVTCTAFKSSANEFVTQEIPTDALEGRLRKLVQLGEAYVVLPGGTGTLLELAEVWELKNKRFFAADKPVIILGEFWKPLVELMKQQDEKCDKCLSFAADPDEAVEIINRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKU8</accession>
    <name>A0A1U9NKU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent phenylglyoxylate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="3">1.2.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">padG</name>
        <name evidence="3" type="ORF">STSP2_01587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.58" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01587"/>
    <dbReference type="EnsemblBacteria" id="AQT68427">
        <property type="protein sequence ID" value="AQT68427"/>
        <property type="gene ID" value="STSP2_01587"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01587"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047110">
        <property type="term" value="F:phenylglyoxylate dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="353" mass="38192" checksum="CAB7CC23E43A3BBB" modified="2017-06-07" version="1">MAEKILLKGNEAMVEAAIEAKCRFFAGYPITPQNEVPETMARRMPQVGGTFIQAESELAAINMIFGASAAGARCMTSSSSPGISLKLEGISYIAAAELPCVIANVQRGGPGLGNIRAAQGDYFQAVKGGGHGDYRLIVLAPAGVQELYDLTMKAFDWADLYRNPVLMLGDGLLGQTAEPVVKKKYRPACKLPKKDWALTGCTNRKSNVVKTLMLGSVEALADHNRHLVQKYKKIESELSLVEEYMTDDAELIVSGYGMTARIAKGAVKNARAKGLKVGLIRPISVWPFPTDTFKRAAEKADKFLVVEMSNGQFVEDVKLAIECKKPVEFMGVGGGWYPTPENVLEKIETVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKX0</accession>
    <name>A0A1U9NKX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase glutamine amidotransferase component II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ORF">STSP2_01751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01751"/>
    <dbReference type="EnsemblBacteria" id="AQT68583">
        <property type="protein sequence ID" value="AQT68583"/>
        <property type="gene ID" value="STSP2_01751"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01751"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22120" checksum="1A9DA7222E3FB7E8" modified="2017-06-07" version="1">MSDKKCKVLFIDNFDSFTYNLVDEFGKRDCELLIYRADTPMEVLKRVADEFGPDLLVISPGPGNPDTAGVTLEAIEHFKDSVPIFGVCLGLQSIVQHFGGKIGHAPCVMHGKSSRITHAGEGVFEGIENPLHAGRYHSLSAIDVPDCLKVTAEFDGIPMGIQHRELPIHAVQFHPESILTPTGGKIIENVMKIAAEGSELASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKY6</accession>
    <name>A0A1U9NKY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68250">
        <property type="protein sequence ID" value="AQT68250"/>
        <property type="gene ID" value="STSP2_01406"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01406"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17842" checksum="053AF16A686BF660" modified="2017-06-07" version="1">MAKHKTSKLKPIVSVKQMAEMLNLSRARFYQLLDEGIFPQPIYDLRTRRPLYDARLQKRCLEVRDTGIGDNGRYILFYSPREKSESQPRKQNKGKTTANLKYQELTETLNSMGLDCSAKEAGSAIEEIYPEGIEHEDEGVVIREIFRYLRQKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKZ2</accession>
    <name>A0A1U9NKZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="8">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">queG</name>
        <name evidence="8" type="ORF">STSP2_01780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01780"/>
    <dbReference type="EnsemblBacteria" id="AQT68612">
        <property type="protein sequence ID" value="AQT68612"/>
        <property type="gene ID" value="STSP2_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01780"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33828" checksum="92DE258F5B0BD83E" modified="2017-06-07" version="1">MAFELGFDLVGFTTAEPVSEKHSARLRDWLASGHAGDMHYMGRNFDKRTNPRALLPNARSVICVGLNYRTTKNGKPGAFANYALYEDYHKFVKDRLYMLAVEIKERVSPDRFKFKVCVDTVPLAERAIAERAGLGFIGKNRMLINPRLGGQILLGELVSTLDLPADNPIKNKCDGCNHCVEACPTGALHIDGTLDASRCISYLSMEHKGDIDEQLAGKMDGQLFGCDRCMLACPFEKIAPIRHNSDIRYFPERCNITAEQVLHWDEKDFLKVLSDSPCDRAGLAGIKRNARIAMANRKHDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL02</accession>
    <name>A0A1U9NL02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C4-dicarboxylate-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dctP</name>
        <name evidence="2" type="ORF">STSP2_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01790"/>
    <dbReference type="EnsemblBacteria" id="AQT68622">
        <property type="protein sequence ID" value="AQT68622"/>
        <property type="gene ID" value="STSP2_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01790"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="324" mass="36509" checksum="237D4F3F9FD2AAE2" modified="2017-06-07" version="1">MKRIAFLTVLSLAVVIGGCKKDDSKARVLKLAHGLNTEHPVHKAMMFMAERVKEKSDGKMLVHVYPSEQLGNEKECIEALQLGYLAMTKTSSGPMENFVPEIKVYGIPYLFRDSEHFWKVMKGPIGKELLVAGEEKGLRGLCYYDAGARSFYAKKPIEGPDDVEGLKVRVMSSIMAMQMIEYMGGSPTPISWGELYTSLDQGVVDAAENNPPSFYTSAHYEICDYYSLDEHTRLPDMLVISSKVWDSLTPEQQQILSEAVDESVEHQIKLWAAAEEESMEAVQEAGVTILRPDKEPFREAVKPMWEQYEDTNLGTLIERIQEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL13</accession>
    <name>A0A1U9NL13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mercuric resistance operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">merR1</name>
        <name evidence="2" type="ORF">STSP2_01574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01574"/>
    <dbReference type="EnsemblBacteria" id="AQT68414">
        <property type="protein sequence ID" value="AQT68414"/>
        <property type="gene ID" value="STSP2_01574"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01574"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9761" checksum="4E7298C031457AEE" modified="2017-06-07" version="1">MAENFETPAKRYRIGEVVRHTPFTRQTIHNYTTMGLIQECGWTEGGHRLYDESVFERLKLIMDLRKTKTLSEIKTILLSSGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NL50</accession>
    <name>A0A1U9NL50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68236">
        <property type="protein sequence ID" value="AQT68236"/>
        <property type="gene ID" value="STSP2_01392"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="397" mass="46556" checksum="C3B60A880B932596" modified="2017-06-07" version="1">MRKYNPYRNIFYYYRGPSFRKKDGQWDKQLEDNITKALVNTLENSDRGLLKRLMKRLGIKPKSYDPVLYDLQITEENSRPDALIKVGSTKIYIESKVDCPLEDEQILNHLQADPDSYLVCITPRNRDAAILDRLKDKRFHFITWKEVYLLFRPFADKDNDARTAFILQEFLDFLEATNMAPFSGWKKSHFEAFLNIEDDPKRELRLKVKDNMQSYLEELKQRLGTSGMYGELDVNVGNIRQDSVHCWGILCPPPLSRKIDVSHFRFAIDADAFSVGVLIGGKKPVDRFKQHTELSSDELQSILGKMDGFHLTLLERVQIRPRRFKGKEVAHILLGENICKYDIDYLNNKFSQYNLLEIRCQKLFKRDDAALGSDHFLDDSIELMKKLEPYYRFAWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLA2</accession>
    <name>A0A1U9NLA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01444"/>
    <dbReference type="EnsemblBacteria" id="AQT68286">
        <property type="protein sequence ID" value="AQT68286"/>
        <property type="gene ID" value="STSP2_01444"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01444"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15914" checksum="1E27C0F9B15691ED" modified="2017-06-07" version="1">MKIKQISVFLENRKGRLFDACSILGQNGVNIRACTIAETETFGVLRIVVDKAEQAVEVLKDNGFVANITSVVVAEVADEPGGLAKILKTLSDNDVNIEYMYGFVEKFTDKALMVFRFEDTDRAQKILQQNGIKIINQEEVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD4</accession>
    <name>A0A1U9NLD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_01924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68752">
        <property type="protein sequence ID" value="AQT68752"/>
        <property type="gene ID" value="STSP2_01924"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01924"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT68752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6877" checksum="3D4D0B309B532113" modified="2017-06-07" version="1">MDQEQKKIVPKPGECIPWEVKRQEYPKIVGDEEVLKKTWQEVDQLAYTYVWHVLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLD9</accession>
    <name>A0A1U9NLD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylcobalamin:coenzyme M methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68753">
        <property type="protein sequence ID" value="AQT68753"/>
        <property type="gene ID" value="STSP2_01925"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01925"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="176"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="396" mass="44416" checksum="AC6C2859CA498C5D" modified="2017-06-07" version="1">MDMEKVYQERLKRYTTALKNEKPDMVPIRPLVAEFTAKYTGFTCQELSQDCNKAFEAACICAKDFDWDAVCPNMVYVWAGITQANGSKYYAMPGVEISADTAFQYREPSEDDAFMKPDEYDELIADPTGFLANVWLPRTSTDVAAPGQPTSFRNNMAFLRGGMAMLNYFSSFGPQCERLRKECGTVPAIAGMLKAPLDIIGDKLRGYIGLTMDLMERPEKVKKACEALIPHLAYNAIASAGSATNFPVGFWMHRGCTPFVTQEQFDNIYWPTLKPVIEAIWESGHQTMFYAEGNWDNHLEAFTELPDRSIVYHVDQGDIFKAHKVLGDKFCISGGIPNALLSYGTPDEVRQRCKEVIDGVAKDGGYIMDASAIMQNDTNVENIKAMTEFTREYGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF9</accession>
    <name>A0A1U9NLF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68665">
        <property type="protein sequence ID" value="AQT68665"/>
        <property type="gene ID" value="STSP2_01834"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01834"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9440" checksum="7F6F86162FDB8A56" modified="2017-06-07" version="1">MDLRKDVSIQNDKLVRQLKHFTSKPQNDGFSENLKKVDFDGKEALEDLKTEYLNKERPMETKGDKGKGSEDAKAGEAAPDTGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLG8</accession>
    <name>A0A1U9NLG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trpD2</name>
        <name evidence="3" type="synonym">trpD</name>
        <name evidence="6" type="ORF">STSP2_01752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01752"/>
    <dbReference type="EnsemblBacteria" id="AQT68584">
        <property type="protein sequence ID" value="AQT68584"/>
        <property type="gene ID" value="STSP2_01752"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01752"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="76"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="110"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35717" checksum="2DB6F06D260D2E8F" modified="2017-06-07" version="1">MAKITEYLELILEGENLTFEQSKELLDTIFDGEVADVQIAAFLAAMRVKRATVEELAGLASSLRSHCVKVETGLENVVDTCGTGGAKLKTFNISTAAALVAAGAGVPVAKHGNRGITSSCGSADVLEALGVNVEASPDVIAECITKAGVGFMFAPRFHPAMKHVQPVRKSLDFRTAFNILGPLANPANATGQVMGVPSDDMMMRIAKSLQMLGIKKAMVVHSEGLDEISTLWPTKIATVCEDDVKVDVFDPRDHGIELARFDDLKGKDAQVNAEIVKGVITGKLDGPKKDIVLINAAAAIMVGLKADNFDEGLAMARESIQSGKAQGSLDKLVEISNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLK6</accession>
    <name>A0A1U9NLK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">STSP2_01536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01536"/>
    <dbReference type="EnsemblBacteria" id="AQT68376">
        <property type="protein sequence ID" value="AQT68376"/>
        <property type="gene ID" value="STSP2_01536"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01536"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="348" mass="38201" checksum="017A4EAC2ED88B66" modified="2017-06-07" version="1">MLTEQLNFDLPGELIAQKPASVRSKSRLLALKRGTSQVEDRVFEDICEYFQPGDCLVLNNTKVLPARFFGRRTSGATLEGLYLSSTDEGLWEVMLKNARRVKEGEVIVLSSRDKGDFCEAVCRQRLGGGRWLLEVEASSVEEVLGEIGFAPLPPYIKRPGGGDQSREDIERYQTVFAQQAGAVAAPTAGLHFTPELLQRLSDKGVITAEVTLHVGAGTFKPVTAEKLEDHHIHSERYEVGEKAAETINAVRENGGRVVAVGTTAVRTLETVGRSGNAEPGSGDTQLFITPGFEFKLVDMMITNFHLPKSTLLALVGAFAGLDNVMAAYRHAVQQEYRFYSYGDAMLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLQ7</accession>
    <name>A0A1U9NLQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01909"/>
    <dbReference type="EnsemblBacteria" id="AQT68737">
        <property type="protein sequence ID" value="AQT68737"/>
        <property type="gene ID" value="STSP2_01909"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01909"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11547" checksum="738A514B13CD54FB" modified="2017-06-07" version="1">MLLGLLWNIVFPINKEMWTSSFTVFTAGLSFLLLAVFYSIIDVIGFSRWAFPFVLIGLNAITIYLGAHHAINFGYTTNFFFAGLVNKVGGATGAISFGLSVSSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLR5</accession>
    <name>A0A1U9NLR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xpsE_3</name>
        <name evidence="3" type="ORF">STSP2_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01685"/>
    <dbReference type="EnsemblBacteria" id="AQT68520">
        <property type="protein sequence ID" value="AQT68520"/>
        <property type="gene ID" value="STSP2_01685"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01685"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="583" mass="64840" checksum="A8A5372651EDF621" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMB4</accession>
    <name>A0A1U9NMB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">STSP2_02050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02050"/>
    <dbReference type="EnsemblBacteria" id="AQT68874">
        <property type="protein sequence ID" value="AQT68874"/>
        <property type="gene ID" value="STSP2_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02050"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38555" checksum="CB1EFE48E98445CF" modified="2017-06-07" version="1">MSPAWTSTHKQFMTVSIRVLIAAGALYLVFKGEDLTELGDVMLGLNKLVFAGALGLYLAGQAVFVLRWRLISSVQSVHFGFFAGLKLHFLGLFYNNCLPSAVGGDLLRAWYVTKHCDPDRKVEAVLSVAVDRAVGLIGMILMAATFYFLWPVETADAQTAPVTAGEGGGQLVGFLKFGGVLFLCVLFALAVLTASKKGRNWLVSLVSRVEHLFIHVVKTFVTAVGLYSRRMHVILLGIVLTFFSQGLCILGFWLCGRNLGLDVNVKYYYVLFPVSWMIGSLPISIGGVGLMEGWLKIAFTKLSGGQSVLAAAVAICQRLIWLIGSIPGLLIHIFGAHLPTHKEEIFIDSAEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMD5</accession>
    <name>A0A1U9NMD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_3</name>
        <name evidence="8" type="ORF">STSP2_02254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69069">
        <property type="protein sequence ID" value="AQT69069"/>
        <property type="gene ID" value="STSP2_02254"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02254"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="373"/>
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</entry>
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</entry>
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        <source>
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        </source>
    </evidence>
    <sequence length="407" mass="44612" checksum="B83ADAE78BE76DE5" modified="2017-06-07" version="1">MSNHRVCGLIVFLGIFGCLLADDAFEFDREVRRFAGKSTISSGLVAQSDDSSVRDVSADQNSYPHCSSESDDASSKVSPAFDPNTFADKLEYLGVAVEEPGWHVWGTSPVMADDGKVHLFCARWPISARFDPGWRIASQIAHYVGDGPEGPFKFSDVALSGTGKDTWDKTGVHNPAIHRVCDKYVLLYISNTGLEGHPANQCIGMATADSPYGPWQKVGEDGLILAPPEDESYWNYGSGCGVNNPAFLQHPDGRFFLFFKSRPGNRGGTKMGLAIADKLEGPYVQKRKPITANDRAIEDGYAFASGGKIYLLTTDNHGMLKRGGGLLWVSDDGENFESIPRPGFDLFANYLPSEDRSQAKRIYGGQLKFERPQVLMIDGRPAYLYMPSGFNIKGGNGTISHVLRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNE7</accession>
    <name>A0A1U9NNE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02631"/>
    <dbReference type="EnsemblBacteria" id="AQT69441">
        <property type="protein sequence ID" value="AQT69441"/>
        <property type="gene ID" value="STSP2_02631"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02631"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_13" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="2">
        <location>
            <begin position="251"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="410" mass="46151" checksum="3C857EE4B412CB32" modified="2017-06-07" version="1">MLTKTKVKCRSCGEENLNTFLDLGHTPVADRILTAEQLQQPEPRYPLEVAFCPECSLVQILETVDPKELFCNDYPYYSSVSAYLMEHSRRNAEELIESRKLNGDSFVVELASNDGYLLRNYVEHSIDCLGIDPAEGPARAAQKIGVPTLCTFFTEQLAERLARQGKKADVIHANNVLAHVADTNGFVSGIRTLLKDDGVAVIEVPYLHDLIRKCEFDTIYHQHLCYFSVHALRKLFKSHGLSLNRARKLDIHGGSLRLFVEPFEKVDASVTELLDVELHEGITNREFYRDFGIRVASVRTSLIDLLGTLKNQGKTIAAYGAAAKGCMLLNYVGLDTSIVDYIVDLNPHKQGKFMTGTHQPISPPARLLDDMPDHVLILAWNFADEIMEQQKEYHDRGGRFIIPIPEPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNL3</accession>
    <name>A0A1U9NNL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69106">
        <property type="protein sequence ID" value="AQT69106"/>
        <property type="gene ID" value="STSP2_02293"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02293"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="440"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="558" mass="62008" checksum="F2AF4167B08F69BC" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNX6</accession>
    <name>A0A1U9NNX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major pilin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69216">
        <property type="protein sequence ID" value="AQT69216"/>
        <property type="gene ID" value="STSP2_02404"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02404"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="281" mass="31935" checksum="93578134C30CF3D9" modified="2017-06-07" version="1">MSRNKGFTLIELLVVISIIALLLAIMMPALQKVKLVAEEVICRSNLKQYGLAGELYRQDNGDKFPNAWDSVFRSRDPARGCQWHDASRHPEDNPELQGTLWDYLGGGTKVHYCRTFARYAKTADAHVGHNDSIPIEPLFCYSMNAFLGGFESYNPASMVIKSSQVRRPSTVFFFAEENAWPYESSETDPYYPYNRYQQTLNDNALCGGPYLPYDVRSWDIPRDQVPPYQDAFGSFHKTSPSKLNDGMANSVFVDGHVEMVEPDRTWYYTKPMDGKPAIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP01</accession>
    <name>A0A1U9NP01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69527">
        <property type="protein sequence ID" value="AQT69527"/>
        <property type="gene ID" value="STSP2_02718"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02718"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13490" checksum="274ECF04F80D8AA1" modified="2017-06-07" version="1">MHKQYHGKTWKIRSAKRYPQARNHIIIGRVVDTTEAFIRIKCRTFHFGRTVTSAKDIDIGPNMTRIVPWNSIEIVNELPDSFDYASAELILDSKGRVALKDHNYLSPLCSRSEQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP43</accession>
    <name>A0A1U9NP43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfp pilus assembly protein PilW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_02760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69567">
        <property type="protein sequence ID" value="AQT69567"/>
        <property type="gene ID" value="STSP2_02760"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02760"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19415" checksum="088B073AD1182443" modified="2017-06-07" version="1">MNKQTRRELNTRHSGVRARSGFTMVEILIALSVTAMLMTAVALAFDASVKNYTTNENLYKAVNNARQALTRMTTELRTAQAVATSEGTSQLSMVNSAGDDITYAYDSNNQTLELITNDDTTDSDYIVCRNVTAVDFQRTTVPDEPGVVRDVQLSITLDIGDVSRTIATAAVLRRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NP87</accession>
    <name>A0A1U9NP87_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lspA</name>
        <name evidence="8" type="ORF">STSP2_02915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02915"/>
    <dbReference type="EnsemblBacteria" id="AQT69719">
        <property type="protein sequence ID" value="AQT69719"/>
        <property type="gene ID" value="STSP2_02915"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02915"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21565" checksum="97B595505E1DB3C8" modified="2017-06-07" version="1">MTDNAKQKGSNTQAGKFNLADRLPDVKSHLIFWPVVIAGVAADLWTKTAVFEWLAKRPDHEYAVIDGIFTLVRRVNPGAAFSMASGRRGMLLTISFVALVAVIVYFLFGRIKSRLMQLGLALFTAGIIGNLYDRLFNDGYVRDFIDIHWKEVYHWPAFNVADSMLCIAVGLLIISNFTSASSQTPDPQQKPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC1</accession>
    <name>A0A1U9NPC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02960"/>
    <dbReference type="EnsemblBacteria" id="AQT69763">
        <property type="protein sequence ID" value="AQT69763"/>
        <property type="gene ID" value="STSP2_02960"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02960"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012482506" evidence="1">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="523" mass="55895" checksum="483D3989F170FFA5" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPC5</accession>
    <name>A0A1U9NPC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69759">
        <property type="protein sequence ID" value="AQT69759"/>
        <property type="gene ID" value="STSP2_02956"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02956"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012956682" evidence="3">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="371" mass="41134" checksum="EE35CF8877F9E621" modified="2017-06-07" version="1" precursor="true">MSHSCFCYRIAGVLCLTVLIMSATATVVGGEVEAESIDKMKAQLEGKTFRYQEVSGIGLENGITRRDPSDIIRVGETYYVWYTKVDHAKLPRNFLHLKTSGYVGTIWYATSTDEGRTWTEQGQALGLGKKGAFDSFAVFTPNIVKFGGKYYLYYTGVKPTNEDKFFFENNSTTDFTAIGAAVSDSPDGPFTRVSEQPALEVGPRASEEKAKSAFDSYRVDDAALLVRDFDGDGDEDVWLYYKGRNIDHGRRGPLFTKMGVAVADRPESEHVRLNQGKAILDKSHEVMIWPWHEGIGAYASLTKTIEYAPDGLDFTSQPLGVKVVPKPVAPACFREDLTRPVDEGKLISWGISMKNPGGPSPFLIRFELVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPF3</accession>
    <name>A0A1U9NPF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na(+)-translocating NADH-quinone reductase subunit C</fullName>
            <ecNumber evidence="13">1.6.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nqrC</name>
        <name evidence="13" type="ORF">STSP2_02681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.-" evidence="13"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02681"/>
    <dbReference type="EnsemblBacteria" id="AQT69490">
        <property type="protein sequence ID" value="AQT69490"/>
        <property type="gene ID" value="STSP2_02681"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02681"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010204">
        <property type="entry name" value="NqrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37838">
        <property type="entry name" value="PTHR37838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="12">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22776" checksum="4BCD430FAC31E5B4" modified="2017-06-07" version="1">MTNKVWYPVVYMFIVTAFFSSVLIGFTFSTQERVEANEQIAFERAVLEAVARNGDLKRQQVHDKFVELMQGPKEDGSYELVEDGETKGYALPVAGKGFWAPIRGVIGFEKDRKTITGIAFYEQNETPGLGGKIMEEDWRRQFQGKVIAQQGKPLQIEPYGSELDQNEVEAITGATQTVKRLEVLINEDIQQWKGGSTETDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPK0</accession>
    <name>A0A1U9NPK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">STSP2_03041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03041"/>
    <dbReference type="EnsemblBacteria" id="AQT69843">
        <property type="protein sequence ID" value="AQT69843"/>
        <property type="gene ID" value="STSP2_03041"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03041"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14261" checksum="78C2991C85CD2628" modified="2017-06-07" version="1">MIQQESMLEIADNSGVKLAQCIKVLGKGGARKGKYVRPTASVGDVVSVAIKRNLPNCQLDTKKIHRCVIIRTKYPVRRKDGSYVRFDSNAAVMIDPEGNPIGTRIFGAVARELREKNYMKIISLASEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPL6</accession>
    <name>A0A1U9NPL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF_2</name>
        <name evidence="3" type="ORF">STSP2_02852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02852"/>
    <dbReference type="EnsemblBacteria" id="AQT69658">
        <property type="protein sequence ID" value="AQT69658"/>
        <property type="gene ID" value="STSP2_02852"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02852"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="95"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36468" checksum="9C1463BBAD81A5C0" modified="2017-06-07" version="1">MIVVMKPGATKEQIQHVVDVVNDYGLKDHVIYGTDRTVIACLGDKRSVDKGAIENAPMVEKVVPILAPYKMASLEVKREKSIIEIGPERFPLGSNKVGIIAGPCAVESREQLMASARAVKKAGCIGLRGGAFKPRTSPYSFQGMGEEGLKLLAEAREETGLAVVTEVIGLEQVEVVAKYADVLQVGARNMQHYPLLEALGKVDKPVLLKRGMSARLDEFLLAAEYIISAGNGKVILCERGIRTFEEYVRNTLPLTAVAELNDKTHLPVIVDPSHGTGHAHLVPSMSTAAVAAGADGLIIECHPDPEHATSDGAQSITPASLDKLMKRLKRVAQAIDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPQ1</accession>
    <name>A0A1U9NPQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03012"/>
    <dbReference type="EnsemblBacteria" id="AQT69815">
        <property type="protein sequence ID" value="AQT69815"/>
        <property type="gene ID" value="STSP2_03012"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03012"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="50"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="296" mass="34016" checksum="13FFB927F6D7E5B7" modified="2017-06-07" version="1">MRYWSLYLIRRQNFYLFFLLCLTFFSGCCLRPDSTSPGDQFDSRQKESIRFIVAADPQLFRGDKSDLVEAIQLINRLEPDFVVMCGDLVETPSNMEQIRAYKDAVTELSGDIPLYNLPGNHDLGRPVGSNNISTYQQHFGELWFDFEYGDGLFIGLCSDILADADAPMHGEHKKWLWDILDSPEAKKAENIFVFMHHPLYLNSPDEPGAYSNMPVGIRKELLEFFVQNGVQAVFSGHFHDNRINSYQGVDLITTNSITAPLGKIPAGFRVVEVRQERYEQTYYTTEELKKEIETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPR1</accession>
    <name>A0A1U9NPR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase, MG_246/ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">STSP2_02930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02930"/>
    <dbReference type="EnsemblBacteria" id="AQT69734">
        <property type="protein sequence ID" value="AQT69734"/>
        <property type="gene ID" value="STSP2_02930"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02930"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30982" checksum="5B4091370D6F8059" modified="2017-06-07" version="1">MKARVLCIGDIVGRPGRHILSQVLPAYVRDNNIDCVIANAENAAGGSGLTPQIYEKLLRYGVNLVTLGDHAYRKRDIVSTLETADNIVRPANLSPEAAGKDFAIYQTANGVRVAVITLIGRIFMKPADCPYARIDALLSKIQNQNLADVIFVEMHAEATSEKVAMGYYLDGKVACVFGTHTHIVTADETLRTKGTAYITDIGMTGAHESVLGRKTEKVIKAFRTQMPFPFEIATEDQRVSGIVVTVNSNTHLAESIERVQLTCSETDSQGYDSDDGRPDRPSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPV8</accession>
    <name>A0A1U9NPV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpoA_2</name>
        <name evidence="11" type="synonym">rpoA</name>
        <name evidence="13" type="ORF">STSP2_03025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03025"/>
    <dbReference type="EnsemblBacteria" id="AQT69827">
        <property type="protein sequence ID" value="AQT69827"/>
        <property type="gene ID" value="STSP2_03025"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03025"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AQT69827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37587" checksum="5413EB2684941F23" modified="2017-06-07" version="1">MRITWRGLELPTRFERDTEISTDRYGRFYVEPFERGFGTTVGNSLRRVLLSSLEGSAVTSIKIKGVDHEFTSMDGVLEDITKIILNVKQIIVHMDTDQPRTVVVKSSKAGEVTAGMIETDPSVEIINKDLVIATLTKDIDFEMEMEIESGRGYSPAAERIAEEDRFEQDTGLIVVDAIYSPVTRVRYKTEDTRVGQKTNYDKLILEIWTDGTVRPDMALVEAGKILRKCINPFVHYSEIGPETIEEEVVQKEAEEEAVDAELEEKLNTPIEELDLTVRSNNCLESMNIRTVRELAKMTEADLLKIRSFGKTSLREIRRKLADMGLTLGMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPX3</accession>
    <name>A0A1U9NPX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_00576</name>
        <name evidence="2" type="ORF">STSP2_01449</name>
        <name evidence="3" type="ORF">STSP2_02485</name>
        <name evidence="4" type="ORF">STSP2_02668</name>
        <name evidence="5" type="ORF">STSP2_02854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67429">
        <property type="protein sequence ID" value="AQT67429"/>
        <property type="gene ID" value="STSP2_00576"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68291">
        <property type="protein sequence ID" value="AQT68291"/>
        <property type="gene ID" value="STSP2_01449"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69296">
        <property type="protein sequence ID" value="AQT69296"/>
        <property type="gene ID" value="STSP2_02485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69477">
        <property type="protein sequence ID" value="AQT69477"/>
        <property type="gene ID" value="STSP2_02668"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69660">
        <property type="protein sequence ID" value="AQT69660"/>
        <property type="gene ID" value="STSP2_02854"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00576"/>
    <dbReference type="KEGG" id="alus:STSP2_01449"/>
    <dbReference type="KEGG" id="alus:STSP2_02485"/>
    <dbReference type="KEGG" id="alus:STSP2_02668"/>
    <dbReference type="KEGG" id="alus:STSP2_02854"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT69477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="79" mass="9025" checksum="A8192F822780282A" modified="2017-06-07" version="1">MSQQDWIEEAVAEFRKGCQELHDELDSAANGTLLDVSDDQIVRTLEPLLKDVQRKAIQTALEKSQTDSDYRRCGKCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ16</accession>
    <name>A0A1U9NQ16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">STSP2_03115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69915">
        <property type="protein sequence ID" value="AQT69915"/>
        <property type="gene ID" value="STSP2_03115"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03115"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19804" checksum="99B5A7FBF1080739" modified="2017-06-07" version="1">MSELEVRRAPLVWWIGGILLGLTQILAVALEKPLGVSTQFVVADSKVMHKVAPEYAQEHELISHEKYQKFGYGWWLDIGLIVGAFVAAVAIGRWRPRFTTVWWRATLNRGILSRLVTGFFGGFFILLGARIAHGCTSGQFASGWAQLSLSVIPFTIAMFVFGVFTAHLVYPGVPKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ17</accession>
    <name>A0A1U9NQ17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03200"/>
    <dbReference type="EnsemblBacteria" id="AQT69999">
        <property type="protein sequence ID" value="AQT69999"/>
        <property type="gene ID" value="STSP2_03200"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03200"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13640" checksum="226C7B95E8C51D78" modified="2017-06-07" version="1">MSLADYFENAQGTGILATTDADGNVDLAVYARPHVENEGTIAFVMADKLSHANLQSNPKAAYMFIEKTDGYQGKRLHLQKIREESDPELVESIRRRKRPDSPDASKSTAVYFKVTKIRPLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ22</accession>
    <name>A0A1U9NQ22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylR_5</name>
        <name evidence="2" type="ORF">STSP2_03234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70032">
        <property type="protein sequence ID" value="AQT70032"/>
        <property type="gene ID" value="STSP2_03234"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03234"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="389" mass="43939" checksum="CC2EB7B72DFC66E0" modified="2017-06-07" version="1">MPANSKVAILIDTSREYGRNVLRGIANYAHDYGPWIFYRKLPFYRVETGEREPTLKMLKKWGADAVIMRQPKDSKTLTELKIPAIISPYTGEPVPNTITVDGDHDDEACLAAEYFLDRGFRNFAYVGLDRFLWSRALAESYERHLESTGRPAHIYTPPTSPKKRYWLNEQKVLGDWLKALPKPLAVFSCTDERARDVLNACRISGITVPDDVAVLGLDNDPMVCNFTFPPLSSIARSVKAASYRAAKLLDQQIAANRPDSRIVLHRPLRVVTRQSTDILAVSDTELYVALNFIRNNIHKNISVESVVRATSLSRRALELRFTTELNRTIAGHIQKTKIQAVKDLLVRTDLSIAEIAHRTGCSSPAYLSTSFKKQTGMSPIHYRLQNHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ26</accession>
    <name>A0A1U9NQ26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lexA_3</name>
        <name evidence="12" type="synonym">lexA</name>
        <name evidence="16" type="ORF">STSP2_03210</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03210"/>
    <dbReference type="EnsemblBacteria" id="AQT70009">
        <property type="protein sequence ID" value="AQT70009"/>
        <property type="gene ID" value="STSP2_03210"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03210"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="102"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AQT70009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24322" checksum="EF39704C75DD0C7C" modified="2017-06-07" version="1">MKKRNETQGVTPRQMEVLKLIWEFENSQCYLPTIAEVSKSMGVSRTTAYEHIAAAREKGLIASADGKARSLSLTKKARTLLKKAGVYSEKQSRGTDEEAGVPLVGLVAAGAPIEAIENVERMSLGSMFGQRDDVFALEVQGDSMIEDGIFDGDLVICKTSSTAENGQLVIAIVEGDSATLKRFYREKNRIRLEPANAAYEPIYTDDCRIEARVLGLVRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQ98</accession>
    <name>A0A1U9NQ98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unsaturated rhamnogalacturonyl hydrolase YteR</fullName>
            <ecNumber evidence="2">3.2.1.172</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yteR</name>
        <name evidence="2" type="ORF">STSP2_03196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.172" evidence="2"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69995">
        <property type="protein sequence ID" value="AQT69995"/>
        <property type="gene ID" value="STSP2_03196"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03196"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102211">
        <property type="term" value="F:unsaturated rhamnogalacturonyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012346511" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT69995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127980" checksum="A6FF6804CDDBF079" modified="2017-06-07" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA3</accession>
    <name>A0A1U9NQA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative selenium metabolism protein, YedE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">STSP2_03114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69914">
        <property type="protein sequence ID" value="AQT69914"/>
        <property type="gene ID" value="STSP2_03114"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03114"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="9">
        <location>
            <begin position="36"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AQT69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25563" checksum="91A207738977A33B" modified="2017-06-07" version="1">MDINVDWTGFVVGALFGASLILSGLANPDKIIGTLRLKDFHALRVIVVFILVGMLGVWILDLAGWANFNVKPAAMLGNGVGGALLGIGFGMTGYCPGTGLACAAAGRIDAIFTVIGMLVGAYFFILAYPAFLYLDSMWNFGEMTILEYTGVSRAILTLSIVAVGGVLLVVTAPRRKVEPEEARPAEVGEARRPLEEQHSRAVEMRGSEEKLKKEGEAEEDEAVPEQERGADDESEGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQA7</accession>
    <name>A0A1U9NQA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69924">
        <property type="protein sequence ID" value="AQT69924"/>
        <property type="gene ID" value="STSP2_03124"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03124"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28453" checksum="20E95B354C297E80" modified="2017-06-07" version="1">MSMQTNCPECGAVYEVDGDLGDRPLRCSGCGHQFFVEQNERSALIIWCVIVGLLCLLGGFLGGVLTTKTTQSEMRAKLAEAEKDKTEAKEVLETADQIVNVLGDVKSQINAAQTSLGKAWIVGSHAGTLETIANIRYNCTNILAQSSTTERKTMVVANLACTLVQLKALQNNLEGFEAEYSDTWLGLAMQPLLDAVRREQAWQNNIIGFCDGSNGDIKFIQPERQEHINSLMGADFQDAFQYVLYDWEDRPFSVSAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQH9</accession>
    <name>A0A1U9NQH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">kduI</name>
        <name evidence="6" type="ORF">STSP2_03195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03195"/>
    <dbReference type="EnsemblBacteria" id="AQT69994">
        <property type="protein sequence ID" value="AQT69994"/>
        <property type="gene ID" value="STSP2_03195"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03195"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="276" mass="30938" checksum="8EBAA1C733DCF0E9" modified="2017-06-07" version="1">MQVRYSADPVRFQRMTTEEIRSEFLIESLFESDKIDFVYSDIDRAVIGSAVPVEKSLTLASADELRAQYFCQRRELGILNVGSAGKITVDGQAFDMANRDALYVGMGSKEITFESADKSSPACFYLLSYPAHKTYPTAQARKADAAAVNLGSEEQCNKRTIYKYIHPDGVKSCQLVMGFTEIADGSVWNTMPPHTHARRMEAYLYFDIPEDARVFHFMGKPEETRTITVADKQAIISPSWSIHSGVGTKAYTFCWGMGGENQAFDDMDHITIDQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQP9</accession>
    <name>A0A1U9NQP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">STSP2_03034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03034"/>
    <dbReference type="EnsemblBacteria" id="AQT69836">
        <property type="protein sequence ID" value="AQT69836"/>
        <property type="gene ID" value="STSP2_03034"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03034"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AQT69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18315" checksum="7D955DB80F1A5367" modified="2017-06-07" version="1">MAEEALKYGAQSDQPLEDTVVKIFRCAKVVKGGRRFSFAALVVVGDRNGTVGIGYGKANEVPQSVEKAIKNAKKDLHKISLIDGTLPHKVVGKSRATKVVMVPASAGTGVIAGSTPRAVLEYAGVHNVLTKIYGSTSAKNVVKAVMDGLLKLRDKETIESLRGVEIEAEAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQT4</accession>
    <name>A0A1U9NQT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport of quorum-sensing signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tqsA</name>
        <name evidence="8" type="ORF">STSP2_03497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03497"/>
    <dbReference type="EnsemblBacteria" id="AQT70291">
        <property type="protein sequence ID" value="AQT70291"/>
        <property type="gene ID" value="STSP2_03497"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03497"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39968" checksum="C6DD669BEA14B30F" modified="2017-06-07" version="1">MQSEGNGKNGQAATRVRKEHFWLMTICLLILAMVAIAMVLHYTQTIMIPFVLSIFIVSLVSPLLDYQVIKLKFNRTMAVCITLLVVLTVIVATCLAVSEAVQTVVSTVKPYMDSVETFTDKVFVQFEEWGLDLSQDSVMEELRKKIPNLVTDTFDTVMGFVSSFVLVSIFVIFLLSGRNPHVIRKGVYADIDNGIRRYIGTKVIISSITGVLVYIILRVLGLELAAVFGMLAFLLNFIPSVGSIIATFLPLPVAVAQFQNFWMISLAIVLPGAVQMTVGNVIEPKLLGRGLDLHPVTVLMALAFWGLLWGVAGMFLAVPITAVIRIVLMQFDTLQPVGRLLSGELPGSSDTGEKSAKGEAERRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQU5</accession>
    <name>A0A1U9NQU5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_03318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="STSP2_03318"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
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        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="31"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="284" mass="32204" checksum="4FE3501B0A8C55B4" modified="2017-06-07" version="1">MASRYRNISRDSIFTSLLILGIIVLLIPHSHTKVINEVFESTFREILSMGPRENPWLGKFEQTKGSSVSKEKYARLQSEYQRVRKEHANTLAQLRESHRRFEQLSGMQSKLPDVGSGLSLSQIVNSRLNGNRRELIINRGRDTGLRPGQYVIGNDAMIGILAEVAESTSRVRLVTDSQQNTEVLIRSEGSDKNIRAQLFGDGAGKCKIKLLPREHKVRENDLVYAANDREFLETPVVIGYIEKVTPDEQKPLLWDITVEPFFDVDDLDEVAVIVMQPDILGQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR67</accession>
    <name>A0A1U9NR67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70016">
        <property type="protein sequence ID" value="AQT70016"/>
        <property type="gene ID" value="STSP2_03218"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03218"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26294" checksum="45C07B885AF1A387" modified="2017-06-07" version="1">MPETAQNIQQVAQEAASMIPVIGGIGCVVFGLFFWLGGLRWSRLIAALVGLVTGGMGIIVSGYGLHGPAVLAMPVGALVGLLANRILLGIMGSLILGSLVMVTVSDKGMPAFNIMFSVEEFRAEDGSFSHESVMAGVRGRVQYYGATLKEYAVGLEGKAITAGVVTAIIALFLRSQILSSVTCASLGTGLIFAGMILVLINKGAAPVERIAERPGLYRLAAGGMLVFGTAVQYALFRGRKADKKVKSNNGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NR77</accession>
    <name>A0A1U9NR77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/glucose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT_6</name>
        <name evidence="8" type="ORF">STSP2_03228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70026">
        <property type="protein sequence ID" value="AQT70026"/>
        <property type="gene ID" value="STSP2_03228"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03228"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AQT70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="548" mass="60434" checksum="6087C46EBDEA9D7A" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRD8</accession>
    <name>A0A1U9NRD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_03298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70096">
        <property type="protein sequence ID" value="AQT70096"/>
        <property type="gene ID" value="STSP2_03298"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03298"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT70096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12384" checksum="0DA8BA3125C4B128" modified="2017-06-07" version="1">MLIELFGSMICRLIIDSIQGGVIGDLQLAWSWLDSLVELMSYRITLVASFLVVILGSIRKNRGISCSLPSVPCLPSLSLEHRSFRSRVEFTRLNQIYSTADSVCCKVIANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRH3</accession>
    <name>A0A1U9NRH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atsA_24</name>
        <name evidence="5" type="ORF">STSP2_03530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70324">
        <property type="protein sequence ID" value="AQT70324"/>
        <property type="gene ID" value="STSP2_03530"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03530"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="480" mass="53257" checksum="A16C7E31EDE47432" modified="2017-06-07" version="1">MHIGRREFLKAAGGVAGLLMAGAVDVFGADRGKRPNIVLCMADDQGWGDMEYYGHPELETPNFNELSKNGLRFDRFYAAAPVCSPTRGSVMTGRHPNRFGCFKWGYTLRPQEVTIAEVLRNSGYVTGHFGKWHIGSVRRGSQVNPGSSGFDEWVSSPNFFDNDPVMSREGDAVQMEGESSMVTAEAAIDFMRKYAGGGEPFFAVVWFGSPHNPHRGAEEDLEHYADAGKKSDFYAEISGMDRAVGRLRDELRYMGIEEDTVFWYCSDNGGLPGYGATGGRGHKGMVYEGGLRVPAVLEWPGKIEAGRVTDVPCNTVDIYPTLVDIVGAKVEKQPVLDGVSLAGMIRGEMEERGKGMGFWDYATGGKPVFSDRWMKNLLKVQSGSAEGLELEHLHADAGKIEKRYSKESFAGHAAWLVWPWKLHRIENKEGAVKFELYNLERDPGEKEDVFGESEGRDERFKAGLREWLESVVDSLNGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NRN1</accession>
    <name>A0A1U9NRN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor SigX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigX_2</name>
        <name evidence="4" type="ORF">STSP2_03391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT70186">
        <property type="protein sequence ID" value="AQT70186"/>
        <property type="gene ID" value="STSP2_03391"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03391"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AQT70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21740" checksum="B349BECECDBDDC4A" modified="2017-06-07" version="1">MQTETKIEHDFDSVVQQARTDAPALGRLYDRYHRPIYRFCMHRVNCRTAAEDIASTAWLAVARQIRTFDGTTETEFRRWLYAIAINQVNTYFRKKNSSKRRLKIVAQTAPDTADEPAVEQDFSAVHSAICQLKPICQTIVTLRFFEDMSFEEIAAIVGKRTATVRVMLHRSLKKLNRILENHYGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NGF4</accession>
    <name>A0A1U9NGF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67012">
        <property type="protein sequence ID" value="AQT67012"/>
        <property type="gene ID" value="STSP2_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00150"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="257" mass="28768" checksum="AAA7D9CAACFB25AE" modified="2017-06-07" version="1">MISESGKTNQSAQSGQPRFAIGEVLLVVFGIIFALVGGFIYVLGLVDISLMIIAVGFLMCTAVIWIAIHRRQWLMVVFAVGGSALSGFSLCSIAYQAIPVRISNVKAPKPLGKLQLADVSKMLHAGRLAELPANARNLRADGWDGLFTGEEYLMFNAPADEVDSWLSASPGLKETVEHFDAEHMLLPQPDNDRERSQLIYEGHELYYLFHRMPRWYRPTVRVKGRRYEIEPDESGHNWGTVVVDDETNTVYVKVIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NHG1</accession>
    <name>A0A1U9NHG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">STSP2_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT67207">
        <property type="protein sequence ID" value="AQT67207"/>
        <property type="gene ID" value="STSP2_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_00350"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AQT67207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="144" mass="17088" checksum="71789EEEAD355A3A" modified="2017-06-07" version="1">MKANPLIVKMFFVVLAVISMGLMYVSFLRDPYSKRIEWTTISLHLIRDNIQTFKDVNQRYPTSLKELSTQVKIDENGLFHKRENKEYISSKNGCDDEYSVLNNKGGWYYNKQTGEIKININKPLKKCFKDYYYLPSRNRVPSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NKV5</accession>
    <name>A0A1U9NKV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General stress protein 16O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yocK_1</name>
        <name evidence="7" type="ORF">STSP2_01301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_01301"/>
    <dbReference type="EnsemblBacteria" id="AQT68146">
        <property type="protein sequence ID" value="AQT68146"/>
        <property type="gene ID" value="STSP2_01301"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01301"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AQT68146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="185" mass="21189" checksum="F68B2948169E34E2" modified="2017-06-07" version="1">MEEQVMDGWLTPQRKSKYKRLLLMKLKEIMGDVSDMERGAFEGSSELSHMPVHLADLGTDNYELEFSLGLMESEKKTIREIIDALKRLEDGSFGICEGLGTPIEKPRLKAIPWTRYSMEYARMIEKGLANPSESFRRRKYDRSVIEEEDDEGGDEDLELEDLDLSSVGVDVDDEESEDAIEEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLF6</accession>
    <name>A0A1U9NLF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-antigen translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">STSP2_01485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68326">
        <property type="protein sequence ID" value="AQT68326"/>
        <property type="gene ID" value="STSP2_01485"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_01485"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AQT68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="450" mass="48574" checksum="B9D37EF9BF53C8F0" modified="2017-06-07" version="1">MREVGLKKLAYKFSPAVAHPVIRRVERSDIASRLAGGAFWSLVGRVVSRGFLLVSLILAARILGQEEYGRVGIVRSTIGTFMIFASFSMSITTTKFIAQYRNTSKSHISGIVFWSLLVVVVAGSLVTLALIGLSPFIASQFINDLSISPMLKLAACILFLVALEGVLQGVLAGYESFGKIALANTVSGITGLVGIILLAQLLGGLGVILGLLLRMAVQVMALGALVFRELRVQGIRPAPIHKRESFKMLFSFGLPAFLGGIVPSIAFWASAVLLTREAGYEQMAIFDAANQFRAGILTLHSAAGMILLPVFSNMFEKEKSRYERVIGKVLTINIVLAGMIFAGIAALSPFLMGLFGEKYALSWHVLVFIALTAALGIGCDILKKVLASQGRMWVNFFTGLIMALILMGTARLCVRYGAFGLSISYTTASTVLLCMLLYYTRTSVKYKTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NLV3</accession>
    <name>A0A1U9NLV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase YcjS</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjS_1</name>
        <name evidence="3" type="ORF">STSP2_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT68913">
        <property type="protein sequence ID" value="AQT68913"/>
        <property type="gene ID" value="STSP2_02090"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02090"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="162"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="401" mass="45187" checksum="0D068AB9D57459F9" modified="2017-06-07" version="1">MAKQGRINGKEKIRIGVVGCGGRGWYDSDRSLKSDPNVEIYAMADLFQDKLDHTLKGLKNQYGDRINVAKNRQFVGFDAYKQLLECDLDLVILTTPPSFRPEHLRAAVEAGKHVFMEKPVAVDPVGVRSVIESSELADKKGLTIMAGTQARQMSHRVELMKRIHDGQIGDIVTGQCFRVGGAMRGWGVEERKADWSDMEWQIRRWLFNTWLSGDFICEMHIHELDIVNWAMGGPPVKCMAMGGREARTDELYGNIFDHFSVEYEYENGVRIFYAGSQIDGATVRTNERIVGTKGIAYTDWARSYIEGENPFKYDGPNPDPCISQHNLQFQAMRNGEKLNQGVRVAHSTLTAIMGRMSAYTGKELSWKWVLNASKLDLSPDKYEFGDMPKPEIAVPGETPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NMS8</accession>
    <name>A0A1U9NMS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal RNA small subunit methyltransferase D</fullName>
            <ecNumber evidence="3">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsmD</name>
        <name evidence="3" type="ORF">STSP2_02227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.171" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02227"/>
    <dbReference type="EnsemblBacteria" id="AQT69044">
        <property type="protein sequence ID" value="AQT69044"/>
        <property type="gene ID" value="STSP2_02227"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02227"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22243" checksum="C3749B9E93F65CC9" modified="2017-06-07" version="1">MRIIAGSKRGMKLLPPKNMETRPITDRAKEALFSVIFKYDMPADCVVGDLFCGTGSMGLECLSRGAKHATFIDQSAQVIDLLEKNISKAHFEAESKVIRGNVFKIGAPVGFEEPKYDLVFVDPPYVMARDTVQKSRLGRLLHLLCEQVRPGAIVIVRTHKRTQLEDQYGELKVIDERSWGSTSVTILRYEPGEQDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NN91</accession>
    <name>A0A1U9NN91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator RfaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">STSP2_02548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02548"/>
    <dbReference type="EnsemblBacteria" id="AQT69359">
        <property type="protein sequence ID" value="AQT69359"/>
        <property type="gene ID" value="STSP2_02548"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02548"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AQT69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20458" checksum="4413210BA79DC7F3" modified="2017-06-07" version="1">MLKASENPPVVWPEGVGIADFEGTWWVAHTKSRNEKALAWQMLKKEIQYFLPMAKKVTKRRGRTIRSFLPLFTGYIFFCGDESDRIEVLKTNRVANLIPVKDQDELVSDLEPIERVIREGQDIRPHNYVKAGQKCRVIAGPLMGTEGIAVTSGEGMRLVLQVDMLGQATSVEVASDLIETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNG1</accession>
    <name>A0A1U9NNG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virus attachment protein p12 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">STSP2_02554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69365">
        <property type="protein sequence ID" value="AQT69365"/>
        <property type="gene ID" value="STSP2_02554"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02554"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7253" checksum="E7296F11685AB208" modified="2017-06-07" version="1">MEHLIIIAIVLVSLVSLIVYYKRKASNPPCDSGGCASCPSGNVCSDETKRQLNQESQSTVNEPENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NNH2</accession>
    <name>A0A1U9NNH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.289</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbbL</name>
        <name evidence="3" type="ORF">STSP2_02643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.289" evidence="3"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AQT69453">
        <property type="protein sequence ID" value="AQT69453"/>
        <property type="gene ID" value="STSP2_02643"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02643"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102096">
        <property type="term" value="F:decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="313" mass="35709" checksum="DA43B4D32EA23E9C" modified="2017-06-07" version="1">MDLSIIIVSWNTKQVLHDCLESVYQQTAGVDFEVIVVDNASSDGSPHMVAHNFPQATLVSNEDNRGFAAANNQGIQKASGEYVLLLNSDTIVLDNAISRTLEFAKQQNDTAVTGCKVLNQDGSLQRSCFMYPSLTNMFMSTFYLNKIFPRSTFFGREAMTWWDREDSREVEVVTGCFMLVKKEAIDRVGMMDEDYFMYGEETDWCYRFNKNGYKIRFTPEGQIIHLGGQSTRQVKPEMIIQLKLSILRFIRKQKGFFAHKVAAMLMIVFFALRLPVWSAIYLADQGRRKEAAIRHSAYLKGIKTVFLSAFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPE7</accession>
    <name>A0A1U9NPE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acoA_2</name>
        <name evidence="7" type="synonym">pdhA</name>
        <name evidence="9" type="ORF">STSP2_02808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02808"/>
    <dbReference type="EnsemblBacteria" id="AQT69614">
        <property type="protein sequence ID" value="AQT69614"/>
        <property type="gene ID" value="STSP2_02808"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02808"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AQT69614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36408" checksum="A4F4508912F90FB7" modified="2017-06-07" version="1">MAQTPDVKKYDKKFLIGLLEQMALIRRFEEKAAQQYGLRKIGGFCHIYIGQEAVATGAVSAVDLAKDYVLTAYRDHGHALAVGMDPKSVMAELYGKKTGCSRAKGGSMHMFDASKNFLGGNGIVGAHIPVSTGVGLKIKYREEDGVVLCFFGDGAIHQGSFHESLNMAGVWKLPVVYICENNQYGMGTDYRRVSAEPDLWKLAGSYKMPGTFADGMNALDVHEKVKTAVERARSDSQPSLIEARTYRYMGHSMSDPAKYRTKEELMEQKEQDPIIILQKQMNEADMLTDDEYKEIDDKAKETVKEAIDFAENSEEPEIDSLYEDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPM2</accession>
    <name>A0A1U9NPM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsule biosynthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">capA</name>
        <name evidence="3" type="ORF">STSP2_02646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02646"/>
    <dbReference type="EnsemblBacteria" id="AQT69456">
        <property type="protein sequence ID" value="AQT69456"/>
        <property type="gene ID" value="STSP2_02646"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02646"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT69456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="363" mass="40849" checksum="767041858F050039" modified="2017-06-07" version="1">MKKKTKIAFLGDIMCGDSFYAMGKGVRRNLCKRGIDFLPESTREILSQHNAVFANVECVISDIDQRPRSLRSMQLRASPYAAVLLRSWGVTVANVANNHILEHGRKAACDTVKNLEAVGIKVVGAGARKDFSGGLSVAKLNCNDETIEIAGISMRNEKYSFNDVHRYEMMLFAERCANAVRPCICSIHWGDEYIDRPSHEQAMFARSLITSGATAVIGHHPHVVQGIEYSRGNLIAYSLGNFIFNGIWKDTRWSVILSLTFEGNVIAEAQLFPIVMDNEYRPHIAAGDQERTILKEVVRRNGILRTVADNPHYQSEYENDLLKKTAGFKKHLRLHTVSSIPTQPPIFWPQILARPLKRRIGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NPU8</accession>
    <name>A0A1U9NPU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_2</name>
        <name evidence="1" type="ORF">STSP2_02951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_02951"/>
    <dbReference type="EnsemblBacteria" id="AQT69754">
        <property type="protein sequence ID" value="AQT69754"/>
        <property type="gene ID" value="STSP2_02951"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_02951"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AQT69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="253" mass="27223" checksum="EB21763C6257657C" modified="2017-06-07" version="1">MNVENTTAIITGATGTIGGAIALELARMGCDCVLHYNTRRELAEELAETVRGMGVSAVCVQADLTEAEQIRKLFIRATDAGPARVLVNSAAVFVRQPLRDVTAEGTRRVLDMNLTAAIIASQEFVRSVDTHFTRHVDMEAHPLPIAKIVNLVDVGGERPWANYTTYCASKAGLIAATKSMAKELAPAISVNAIAPGMVNFPRSFSEEERERQLKMIPAGRIGKPSEVAGAVKFLLENDYVTGQVINVDGGRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1U9NQM0</accession>
    <name>A0A1U9NQM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">STSP2_03236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerohalosphaera lusitana</name>
        <dbReference type="NCBI Taxonomy" id="1936003"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Planctomycetes</taxon>
            <taxon>Phycisphaerae</taxon>
            <taxon>Sedimentisphaerales</taxon>
            <taxon>Anaerohalosphaeraceae</taxon>
            <taxon>Anaerohalosphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and description of representatives of a novel lineage of planctomycetes thriving in anoxic sediments.</title>
            <authorList>
                <person name="Spring S."/>
                <person name="Bunk B."/>
                <person name="Sproer C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ST-NAGAB-D1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019791">
        <property type="protein sequence ID" value="AQT70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1936003.STSP2_03236"/>
    <dbReference type="EnsemblBacteria" id="AQT70034">
        <property type="protein sequence ID" value="AQT70034"/>
        <property type="gene ID" value="STSP2_03236"/>
    </dbReference>
    <dbReference type="KEGG" id="alus:STSP2_03236"/>
    <dbReference type="Proteomes" id="UP000189674">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AQT70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000189674"/>
        </source>
    </evidence>
    <sequence length="873" mass="96293" checksum="4670BB33DFEED33B" modified="2017-06-07" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>